Новости Медицины

[Editorial] Eliminating cervical cancer

Fri, 31 Jan 2020 00:00:06 +0000

2020 promises to be a landmark year for cervical cancer and, with World Cancer Day on Feb 4, it is an apt time to reflect on the prospect of elimination. WHO has a highly ambitious plan for elimination: 90% of girls fully vaccinated by age 15 years, 70% of women screened (at ages 35 and 45 years), and 90% of patients with disease receiving care. Two Articles in The Lancet show how achieving these goals would prevent millions of deaths and eliminate cervical cancer as a public health problem in low-income and middle-income countries.

[Editorial] Lung cancer: some progress, but still a lot more to do

Fri, 22 Nov 2019 00:00:06 +0000

In a report, State of Lung Cancer, released on Nov 12, the American Lung Association shows that 5-year survival for US patients with lung cancer has improved from a dismal 17·2% 10 years ago, to 21·7% now. This improvement is attributed to a combination of personalised, biomarker-driven treatment, screening of people at high risk and, therefore, diagnosis at earlier stages, and advancements in research and drug development. Yet progress is uneven by states and by populations. For example, the incidence is 27·1 per 100 000 people in Utah compared with 92·6 per 100 000 in Kentucky.

Trump to Nominate Dr Stephen Hahn to Head FDA

Fri, 01 Nov 2019 16:11:59 +0000

The MD Anderson Cancer Center executive is credited with restoring the giant cancer center's financial stability.
Medscape Medical News

Mohs Surgery an Option for Early-Stage Invasive Melanoma

Sat, 05 Oct 2019 01:21:53 +0000

Mohs micrographic surgery (MMS) may be an effective alternative to wide margin excision (WME) for appropriately selected patients with early-stage invasive melanoma, a large retrospective study suggests.
Reuters Health Information

Primary Hyperoxaluria Type 2 Requires Careful Follow-up

Sat, 05 Oct 2019 01:18:54 +0000

Patients with primary hyperoxaluria type 2 (PH2), a rare inherited disorder, require careful follow-up due to the risk of significant morbidity, according to findings from the European Hyperoxaluria Consortium (OxalEurope).
Reuters Health Information

Optimism Tied to Lower Rates of Heart Attacks, Death

Sat, 05 Oct 2019 01:10:24 +0000

People with a positive outlook on life may be less likely than pessimists to experience events like a heart attack or stroke, and they may live longer, a recent review of existing research suggests.
Reuters Health Information

Head and Neck Melanomas Increasing, Especially Among Boys and Young Men

Sat, 05 Oct 2019 01:10:02 +0000

Although relatively rare, head and neck melanomas have been on the rise in North America, increasing by more than 50% over two decades, researchers report.
Reuters Health Information

FDA OKs Trifarotene, First New Retinol Acne Cream in 20 Years

Fri, 04 Oct 2019 19:18:47 +0000

Trifarotene cream 0.005% (Aklief), approved for patients aged 9 years or older, is the first topical treatment specifically studied and proven to treat acne vulgaris on both the face and trunk.
FDA Approvals

Medicare Plan for E/M Pay Draws Some Specialties' Opposition

Fri, 04 Oct 2019 17:48:39 +0000

Members of Congress join specialty groups in asking CMS to reconsider its plan to overhaul payment for office visits.
Medscape Medical News

COAPT: MitraClip Adds Years of Life, but at a Steep Price

Fri, 04 Oct 2019 16:00:56 +0000

Cumulative 2-year costs were higher with the device than medical therapy but, overall, the cost-effectiveness is comparable with other commonly used heart failure treatments.
Medscape Medical News

Close Call: US Can Still Officially Claim Measles Eliminated

Fri, 04 Oct 2019 16:38:32 +0000

Measles has been eliminated for almost 20 years, and it remains so, despite an almost year-long outbreak that threatened that status, according to the Centers for Disease Control and Prevention.
Medscape Medical News

Zero-Contrast PCI in CKD Patients Helps Avoid Later Dialysis

Fri, 04 Oct 2019 16:53:17 +0000

No coronary lesion seemed too complex for the procedure that used intravascular ultrasound and pressure readings to guide stenting, usually avoiding need for contrast injection, protecting the kidneys.
Medscape Medical News

FDA OKs Asthma Drug Benralizumab (Fasenra) for At-Home Use

Fri, 04 Oct 2019 15:26:20 +0000

The Fasenra Pen is a prefilled, single-use autoinjector for use as adjunctive maintenance treatment for adults and for children aged 12 years or older who have severe eosinophilic asthma.
FDA Approvals

Physician Pay Gap Persists Even in Fee-for-Service System

Fri, 04 Oct 2019 14:26:32 +0000

Differences may be because of "hidden curriculum" that places women at a disadvantage, study authors say.
Medscape Medical News

Sleeping Pills May Cut Risk for Suicidal Thoughts in Depression

Fri, 04 Oct 2019 12:01:50 +0000

Prescribing a hypnotic in tandem with an antidepressant may improve sleep quality and reduce the risk of developing suicidal thoughts for patients with insomnia and depression.
Medscape Medical News

Reducing Obese Moms' Sitting Time Lowers Fat Mass in Newborns

Fri, 04 Oct 2019 12:05:49 +0000

Reducing obese mothers' sedentary time lowered fat mass and leptin levels in their newborns, indicating more attention should be given to getting these women to limit their sitting time.
Medscape Medical News

Long-term Antibiotics Ease Symptoms of Genetic Lung Disorder

Fri, 04 Oct 2019 12:14:59 +0000

Azithromycin improves symptoms for patients with primary ciliary dyskinesia, but researchers caution that vigilance must be maintained to prevent antibiotic resistance.
Medscape Medical News

Unnecessary Antibiotics Before Dental Visit Can Be Harmful

Fri, 04 Oct 2019 12:45:47 +0000

Prophylactic antibiotics before dental procedures can cause serious adverse events and are largely unnecessary. To solve this problem, dentists should become more involved in antibiotic stewardship.
Medscape Medical News

В России растет заболеваемость коклюшем: сказывается снижение популяционного иммунитета

Fri, 04 Oct 2019 18:06:34 +0000

Роспотребнадзор подготовил рекомендации по вопросу вакцинопрофилактики детей перед школой. Особое внимание ведомство обращает на ревакцинацию от коклюша, заболеваемость которым растет ежегодно в 1,5-2 раза. При этом, в Национальном календаре такой прививки нет. Врачи советуют родителям не ждать, когда она там появится, и предохранять детей от опасной инфекции за свой счет.

Исследование: собираешься стать отцом - выйди из запоя заблаговременно

Fri, 04 Oct 2019 17:33:00 +0000

Врожденные дефекты и проблемы развития у новорожденных долгое время связывали только с употреблением алкоголя матерями во время беременности. Китайские ученые обнаружили связь между врожденными пороками сердца детей и пьянством его будущих родителями еще до зачатия.

Brain Age Gap a Novel, Reliable Marker for Dementia Risk?

Fri, 04 Oct 2019 10:36:18 +0000

The gap between brain age, as estimated with MRI, and chronologic age may serve as a biomarker for dementia risk.
Medscape Medical News

5-Year Survival High for HIV+ to HIV+ Kidney Transplant

Fri, 04 Oct 2019 10:39:33 +0000

Study following kidney transplants from donors with HIV infection in South Africa to HIV positive recipients shows high rates of 5-year overall and graft survival.
Medscape Medical News

Cancer Drug Combos Causing Cost-Effectiveness Headaches

Fri, 04 Oct 2019 02:19:05 +0000

Tackling issues around the cost-effectiveness of oncology drug combinations could lead to disappointments as health services struggle to justify the increase in budgetary demands, suggest experts.
Medscape News UK

В России учреждено Национальное общество по изучению сексуального здоровья женщин

Thu, 03 Oct 2019 11:43:56 +0000

Гинекологи в практическом здравоохранении – эксперты для женщин в области женского здоровья и должны обладать базовыми сексологическими знаниями, уверены в организации. Национальное общество будет работать над повышением уровня информированности врачей и населения в области сексуального и репродуктивного здоровья и укреплением семейных отношений.

Лимон и отбеливатель - опасное сочетание

Fri, 04 Oct 2019 09:05:37 +0000

Исследователи обнаружили, что испарения хлорсодержащих бытовых чистящих средств с ароматом цитрусовых на свету образуют в воздухе мелкие частицы, вдыхание которых наносит вред людям и домашним животным.

Cancer Drug Combos Causing Cost Effectiveness Headaches

Fri, 04 Oct 2019 02:19:05 +0000

Tackling issues around the cost effectiveness of oncology drug combinations could lead to disappointments as health services struggle to justify the increase in budgetary demands, suggest experts.
Medscape News UK

Sanders Presidential Campaign Pivots Health Scare to Medicare for All Message

Thu, 03 Oct 2019 23:27:29 +0000

Bernie Sanders' 2020 presidential election campaign on Wednesday sought to use news the candidate had a heart procedure to highlight the benefits of his trademark Medicare for All healthcare plan.
Reuters Health Information

Sciatica Common, Tied to Other Conditions in Older U.S. Adults

Thu, 03 Oct 2019 23:24:41 +0000

One in four older Americans has experienced the sharp, sometimes disabling, pain of sciatica, and these older adults are more prone to have other illnesses and lowered quality of life, a new U.S. study suggests.
Reuters Health Information

Low-Carb 'Keto' Diets Have Some Health Benefits and Some Risks

Thu, 03 Oct 2019 23:20:22 +0000

While extremely low-carbohydrate diets may aid short term weight loss, they have mixed effects on health markers that can contribute to heart disease risk, according to new recommendations from the National Lipid Association.
Reuters Health Information

Trump Seeks Proposals on Medicare Pay for NPs, PAs

Thu, 03 Oct 2019 18:56:24 +0000

An executive order signed Thursday adds to an expanding reconsideration of how Medicare pays different kinds of healthcare professionals.
Medscape Medical News

Feds Urge Caution About Vaping as Lung Injury Cases Top 1000

Thu, 03 Oct 2019 19:53:26 +0000

The jump in cases could be just the tip of the iceberg when it comes to the escalating health threat this outbreak poses, particularly youth and young adults, federal health officials said today.
Medscape Medical News

[Series] Changing the landscape for type 1 diabetes: the first step to prevention

Thu, 03 Oct 2019 23:00:09 +0000

Over several decades, studies have described the progression of autoimmune diabetes, from the first appearance of autoantibodies until, and after, the diagnosis of clinical disease with hyperglycaemia and insulin dependence. Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical problem that affects children and adults. Clinical and preclinical studies have suggested strategies to prevent the diagnosis of type 1 diabetes in people at risk, but the outcomes of previous clinical trials have not met their primary endpoints of disease prevention or delay.

[Series] Advances in β-cell replacement therapy for the treatment of type 1 diabetes

Thu, 03 Oct 2019 23:00:08 +0000

The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to reduce disease complications. For some patients, technological approaches to insulin delivery are inadequate, and allogeneic islet transplantation is a safe alternative for those patients who have had severe hypoglycaemia complicated by impaired hypoglycaemia awareness or glycaemic lability, or who already receive immunosuppressive drugs for a kidney transplant. Since 2000, intrahepatic islet transplantation has proven efficacious in alleviating the burden of labile diabetes and preventing complications related to diabetes, whether or not a previous kidney transplant is present.

[Series] Advances in technology for management of type 1 diabetes

Thu, 03 Oct 2019 23:00:08 +0000

Technological advances have had a major effect on the management of type 1 diabetes. In addition to blood glucose meters, devices used by people with type 1 diabetes include insulin pumps, continuous glucose monitors, and, most recently, systems that combine both a pump and a monitor for algorithm-driven automation of insulin delivery. In the next 5 years, as many advances are expected in technology for the management of diabetes as there have been in the past 5 years, with improvements in continuous glucose monitoring and more available choices of systems that automate insulin delivery.

[Clinical Picture] Scanning early catches the worm: abdominal ultrasound as a possible screening method for intestinal cestodes

Thu, 03 Oct 2019 23:00:08 +0000

A 23-year-old woman was referred to our hospital for a recurrent discharge of something resembling a white string from her anus. She explained that the problem had started 4 months ago and that she had no other symptoms. She said she had eaten raw fish as sashimi approximately 6 months earlier and that the discharge had started 2 months later. A physical examination found no abnormalities and the blood test results were all normal. However, based on her history, we suspected she had diphyllobothriasis and did a screening abdominal ultrasound scan, which showed a hyperechoic strand-like structure floating freely and moving autonomously in her intestinal tract (figure; videos 1 and 2).

[Articles] Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

Thu, 03 Oct 2019 23:00:08 +0000

This study suggests that women with HFrEF might need lower doses of ACE inhibitors or ARBs and β blockers than men, and brings into question what the true optimal medical therapy is for women versus men.

[Articles] Biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with ST-segment elevation myocardial infarction (BIOSTEMI): a single-blind, prospective, randomised superiority trial

Thu, 03 Oct 2019 23:00:08 +0000

In patients with acute STEMI undergoing primary PCI, biodegradable polymer sirolimus-eluting stents were superior to durable polymer everolimus-eluting stents with respect to target lesion failure at 1 year. This difference was driven by reduced ischaemia-driven target lesion revascularisation in patients treated with biodegradable polymer sirolimus-eluting stents compared with durable polymer everolimus-eluting stents.

[Articles] A community-based comprehensive intervention to reduce cardiovascular risk in hypertension (HOPE 4): a cluster-randomised controlled trial

Thu, 03 Oct 2019 23:00:08 +0000

A comprehensive model of care led by NPHWs, involving primary care physicians and family that was informed by local context, substantially improved blood pressure control and cardiovascular disease risk. This strategy is effective, pragmatic, and has the potential to substantially reduce cardiovascular disease compared with current strategies that are typically physician based.

[Department of Error] Department of Error

Thu, 03 Oct 2019 23:00:08 +0000

The Lancet. Tuberculosis needs accelerated and continued attention. Lancet 2019; 394: 896—In this Editorial, the spelling of the drug pretomanid has been corrected. This correction has been made to the online version as of Sept 19, 2019.

[Department of Error] Department of Error

Thu, 03 Oct 2019 23:00:08 +0000

Stone GW, Ellis SG, Gori T, et al. Blinded outcomes and angina assessment of coronary bioresorbable scaffolds: 30-day and 1-year results from the ABSORB IV randomised trial. Lancet 2018; 392: 1530–40—In this Article, angina reported at the patient visits at months 3, 6, and 9 was not included in the cumulative rates. As such, the cumulative rates and relative rates of angina have been corrected in the Summary, Results (tables 3–5; figure 2B), Discussion, and supplementary appendix. These corrections have been made to the online version as of Sept 18, 2019.

[Department of Error] Department of Error

Thu, 03 Oct 2019 23:00:08 +0000

Ross JDC, Brittain C, Cole M, et al. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial. Lancet 2019; 393: 2511–20—In this Article, the point estimate for intermenstrual bleeding in table 3 was the same as the lower confidence limit, when it should have been 11·1%. This correction has been made to the online version as of Sept 18, 2019.

[Correspondence] Pharmacological treatments for generalised anxiety disorder – Authors' reply

Thu, 03 Oct 2019 23:00:08 +0000

Klaus Munkholm and colleagues raise several interesting issues; however, we disagree that our results1 have a very low level of certainty. Our protocol was published a priori2 and we went to extensive and exhaustive lengths to identify many completed trials, providing the most comprehensive summary of evidence to date using robust methods. More than half of the trials in our analysis were done for regulatory purposes and were held to high standards of study conduct. A 2018 network meta-analysis for depression3 also found high risk of bias according to the scale recommended by the Cochrane Handbook for Systematic Reviews of Interventions;4 in fact, none of those studies achieved a low risk of bias across all categories.

[Correspondence] Pharmacological treatments for generalised anxiety disorder

Thu, 03 Oct 2019 23:00:08 +0000

The network meta-analysis by April Slee and colleagues1 studied the effect of 22 drugs for the treatment of generalised anxiety disorder and showed that several drugs were effective and well tolerated. We, however, consider that the inclusion of 16 randomised controlled trials from China in this network meta-analysis is highly questionable. Only one2 of these trials was registered on a clinical trial registry platform and provided evidence of ethical approval. Ten trials were published by Chinese predatory journals; these journals tend to accept articles with no or inappropriate peer review, meaning that any study can be published as long as the publication fee is paid.

[Correspondence] Pharmacological treatments for generalised anxiety disorder

Thu, 03 Oct 2019 23:00:08 +0000

In their systematic review and network meta-analysis, April Slee and colleagues1 asserted that several pharmacological treatments were effective for generalised anxiety disorder. We would like to highlight several limitations of their analysis.

[Correspondence] Fresh versus frozen blastocyst transfer – Authors' reply

Thu, 03 Oct 2019 23:00:08 +0000

We appreciate the comments from Tjitske Zaat and colleagues and Matheus Roque and colleagues. We disagree that we should have compared the outcomes from two embryo transfers (ie, a fresh and a frozen one) to one embryo transfer (ie, a frozen one only) in our study.1 Whenever time to pregnancy is evaluated as the primary outcome of infertility treatment, it will encourage the rapid use of expensive and invasive assisted reproductive technology and a willingness to tolerate increased patient risk, such as inducing ovarian hyperstimulation syndrome.

[Correspondence] Fresh versus frozen blastocyst transfer

Thu, 03 Oct 2019 23:00:08 +0000

Daimin Wei and colleagues1 coordinated the largest randomised controlled trial on elective frozen-thawed versus fresh single blastocyst transfer in normogonadotropic healthy young women undergoing in-vitro fertilisation. The investigators reported a substantially higher singleton livebirth rate in women in the elective frozen transfer group than in those in the fresh transfer group. However, elective frozen transfer increased the risk of maternal pre-eclampsia and the birth of neonates too large for their gestational age, thus corroborating other new meta-analyses.

[Correspondence] Fresh versus frozen blastocyst transfer

Thu, 03 Oct 2019 23:00:08 +0000

We read with interest the report by Daimin Wei and colleagues,1 in which they concluded that frozen blastocyst transfer resulted in a higher livebirth rate than fresh blastocyst transfer in ovulatory women with good prognosis. However, we consider that the use of the livebirth rate after the first transfer in each arm of the study is problematic in this evaluation. Although biologically interesting, from a patient's perspective this comparison is not relevant when evaluating livebirths. At the time when women in the frozen blastocyst group received their first transfer, women in the fresh blastocyst group had already received their second transfer (of a frozen-thawed embryo) if the fresh transfer had been unsuccessful.

[Correspondence] Semaglutide in weight management – Author's reply

Thu, 03 Oct 2019 23:00:08 +0000

Ying Xiao and Lin Sun raise the important question as to whether smoking status or sleep patterns might have influenced the results of our study.1 They are correct in highlighting that smoking cessation can lead to weight gain and that poor sleep might contribute to difficulty in losing weight.

[Correspondence] Semaglutide in weight management

Thu, 03 Oct 2019 23:00:08 +0000

We read, with great interest, the Article by Patrick O’Neil and colleagues1 on the efficacy and safety of semaglutide for weight loss combined with lifestyle intervention. The authors should be commended for the rigorous study design and statistically significant results, which verified the feasibility of semaglutide on weight management for the first time. However, we want to raise two concerns about the study.

[Correspondence] Preventing unnecessary disability after stroke in Scotland

Thu, 03 Oct 2019 23:00:07 +0000

I am a Scottish-born stroke neurologist now working in an experienced stroke centre in Calgary, AB, Canada. Similar to Scotland, health care in Canada is publicly funded. In December, 2018, my mother had an ischaemic stroke. Over the course of a few hours, it became clear to me just how far Scotland is behind in hyperacute stroke care. The complete unavailability of thrombectomy in Scotland is clearly the central issue, but there are many parts to acute stroke care that need to be changed to make streamlined access to thrombectomy happen.

[Correspondence] Extension of the CONSORT and SPIRIT statements

Thu, 03 Oct 2019 23:00:07 +0000

We read with great interest the proposal made by Gary Collins and Karel Moons1 to develop a version of the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement that is specific to machine learning (ML), to be known as TRIPOD-ML.2 We agree that the understandable excitement around ML-enabled technologies should not overrule the need for robust scientific evaluation, and ML prediction model studies should adopt established guidance for reporting.

[Obituary] Allison Milner

Thu, 03 Oct 2019 23:00:07 +0000

Social epidemiologist specialising in workplace mental health. Born in Melbourne, Australia, on May 1, 1983, she died of injuries in an accident in Melbourne on Aug 12, 2019, aged 36 years.

[Perspectives] Project CREATeS: youth engagement in suicide prevention

Thu, 03 Oct 2019 23:00:07 +0000

Writing in his journal in 1903, from what is now Nunavut, Canada, physician Lorris Elijah Borden said of Inuit, “They are childish in their notions & are easily offended if spoken to roughly…Their morals are lax but it seems alright to them as they know no better.” Two decades later, another doctor, Leslie Livingstone, described his intervention in an epidemic using similar language: “Each family was regularly visited by the doctor and cautioned against leaving their tents until the epidemic had run its course.

[Perspectives] Learning from the past

Thu, 03 Oct 2019 23:00:07 +0000

When I was a house physician, there were always a lot of older patients with chronic conditions on the ward. Often they stayed there for months because they couldn't be discharged home. On the weekly ward round, the consultant never spoke to those patients at all. Instead, he'd wave to them airily after we'd seen the patients with acute conditions and before leaving the ward. I'm ashamed to admit that at the time I thought those older patients were pretty boring too. They didn't have much to say, they were often deaf and forgetful, they repeated themselves, their bodies were falling to bits, and I assumed they weren't of much medical interest.

[Perspectives] Exploring the recovery of survivors of trafficking through art

Thu, 03 Oct 2019 23:00:07 +0000

In 2013, Siân Oram was part of a team of researchers that investigated the physical and mental health and experiences of violence among survivors of trafficking in a high-income country. Known as PROTECT, their survey gathered evidence to inform policies and services in the place where the survivors ended up. The 150 men and women in the UK Oram and her colleagues were able to work with had found themselves in situations of forced labour as a result of human trafficking for sexual exploitation, domestic servitude, or labour exploitation.

[World Report] Brexit and medicine shortages in the UK

Thu, 03 Oct 2019 23:00:07 +0000

As the uncertainty around the UK's withdrawal from the EU continues, Talha Burki reports on the potential implications for supplies of drugs.

[World Report] Polio returns to the Philippines

Thu, 03 Oct 2019 23:00:07 +0000

Cases of the illness have re-emerged in the country for the first time in 19 years. Jacqui Thornton reports.

[Comment] Offline: Extinction or rebellion?

Thu, 03 Oct 2019 23:00:07 +0000

An unprecedented social and political disruption is about to take place. Nothing like it will have been seen for a generation. The outcome could be transformational. Or it could be met with indifference. Remember the antiglobalisation protests in Genoa in 2001? Or the marches against the Iraq war in 2003? The outcomes of October, 2019, depend on the intensity of resistance. What part should health workers play in one of the greatest social movements of our time? The occasion before us is 2 weeks of non-violent direct political action, beginning on October 7.

[Comment] The Global Fund's Sixth Replenishment Conference: a challenge for France, a challenge for global health

Thu, 03 Oct 2019 23:00:07 +0000

By hosting the Sixth Replenishment Conference of the Global Fund to Fight AIDS, Tuberculosis and Malaria in Lyon, France, on Oct 9–10, 2019, President Emmanuel Macron reaffirms France's longstanding contribution to the fight against these three diseases.

[Comment] Gambling harm: a global problem requiring global solutions

Thu, 03 Oct 2019 23:00:07 +0000

Addicted to Gambling, an episode of the BBC's Panorama programme broadcast on Aug 12, 2019, highlighted the profound harms that can be associated with gambling and the impact these have on individuals, families, and society. According to data published in England, problem gamblers are much more likely to think about taking their lives and to attempt suicide than those who do not have a gambling problem.1 Other publications have highlighted the importance of a public health approach to gambling2,3 and research from different jurisdictions shows a similar picture.

[Comment] Sex-based differences in medications for heart failure

Thu, 03 Oct 2019 23:00:07 +0000

Men and women have noteworthy physiological differences. Beyond the traditionally accepted trends in bodyweight and physical stature, women are documented to have slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate than men.1 These translate into sex-dependent differences in medication absorption, distribution, metabolism, and excretion that can affect health outcomes.1

[Comment] Superiority of biodegradable polymer sirolimus-eluting stents in STEMI

Thu, 03 Oct 2019 23:00:07 +0000

After the introduction of coronary drug-eluting stents in 2002, these efficacious devices were rapidly adopted in clinical practice. Nevertheless, controversy remained about the safety of drug-eluting stents in acute ST-segment elevation myocardial infarction (STEMI).1 Later, although in daily practice drug-eluting stents were used in all clinical scenarios and several randomised trials with few exclusion criteria evaluated drug-eluting stents in study populations that included patients with STEMI,2 many studies that assessed newer drug-eluting stents still excluded patients with STEMI.

[Comment] Parallel community solutions for cardiovascular risk reduction

Thu, 03 Oct 2019 23:00:07 +0000

High blood pressure is the leading attributable risk factor for deaths from cardiovascular disease globally. Deaths from cardiovascular disease continue to rise in low-income and middle-income countries where blood pressure control remains poor (<15%).1

[Editorial] Housing and homelessness as a health crisis

Thu, 03 Oct 2019 23:00:07 +0000

Ahead of World Homeless Day on Oct 10, the UK's National Housing Federation last week released new data based on the Understanding Society longitudinal study, drawing attention to the scale and breadth of the country's housing crisis—with 8·4 million people affected in one or more ways. Inhospitable conditions include overcrowding (affecting 3·6 million people), concealed households (2·5 million people), poor-quality housing (1·4 million people), and being homeless or at risk of homelessness (400 000 people).

[Editorial] No health care without social care

Thu, 03 Oct 2019 23:00:07 +0000

The social context of an individual, a crucial substrate for health, has been neglected in the US health-care system. A report published on Sept 25, 2019, by the National Academies of Sciences, Engineering, and Medicine—Integrating Social Care into the Delivery of Health Care: Moving Upstream to Improve the Nation's Health—outlines the case for bringing social care within the realm of clinical practice.

[Editorial] Russia's alcohol policy: a continuing success story

Thu, 03 Oct 2019 23:00:07 +0000

Russians are officially drinking less and, as a consequence, are living longer than ever before: life expectancies reached an historic peak in 2018—almost 68 years for men and 78 years for women—according to a WHO report examining the effects of alcohol control measures on mortality and life expectancy in Russia. The document's release, on Oct 1, coincided with a meeting in Prague (Czech Republic) of representatives from the 53 countries of the WHO European Region, who met to consider the levels of implementation of both the global strategy to reduce the harmful use of alcohol and the European Action Plan on Alcohol (EAPA).

FDA OKs Descovy, Second Drug for HIV PrEP

Thu, 03 Oct 2019 16:57:52 +0000

The combo of emtricitabine and tenofovir alafenamide is indicated to reduce the risk for HIV-1 infection from sex (excluding receptive vaginal sex) in at-risk adults and teens weighing at least 35 kg.
FDA Approvals

Similar Benefits for Thrombectomy, Medical Management, in Mild Stroke

Thu, 03 Oct 2019 17:09:13 +0000

New analyses show no compelling evidence supporting either mechanical thrombectomy or medical management over the other for the treatment of mild stroke, setting the stage for a randomized trial.
Medscape Medical News

Antidepressants Are Safe: Final Word?

Thu, 03 Oct 2019 17:54:04 +0000

There is no convincing evidence of a link between antidepressant use and adverse health outcomes. However, some experts urge caution in interpreting the results.
Medscape Medical News

Salmonella Risk Lower in Organic or Antibiotic-Free Poultry

Thu, 03 Oct 2019 16:42:48 +0000

Antibiotic-free or organic chicken and turkey are less likely to contain Salmonella than conventionally raised poultry, a new study shows, which emphasizes the need for safe food handling.
Medscape Medical News

'Unprecedented' Results in Biliary Tract Cancer

Thu, 03 Oct 2019 14:01:45 +0000

Experts were impressed with results from a phase 3 study of a targeted agent in a subgroup of patients with cholangiocarcinoma with genetic mutations.
Medscape Medical News

Novel, Low-Sodium Drug Promising for Narcolepsy

Thu, 03 Oct 2019 14:07:52 +0000

A novel drug with a low-sodium formulation is both safe and effective for treating symptoms of narcolepsy in adult patients, results from a phase 3 trial suggest.
Medscape Medical News

Meet the Health Officials Who Alerted the World to the Alarming Vaping Illness

Thu, 03 Oct 2019 14:52:10 +0000

It's a tale of teamwork, communication, and long-serving public health officials tapping into their networks in an era of limited public health funding.
Kaiser Health News

TAVR-Surgery Parity at 5 Years, Good Echo Result Key: PARTNER 2A

Thu, 03 Oct 2019 12:13:16 +0000

Late outcomes were similar to 2-year results; worse-than-mild paravalvular leaks after either procedure meant a much worse prognosis in these intermediate-risk patients with severe aortic stenosis.
Medscape Medical News

Income Drop Hard on the Wallet and the Brain

Thu, 03 Oct 2019 12:26:00 +0000

Young adults who experience a drop in income experience poorer cognitive performance and exhibit lower brain volume on imaging in midlife, results of a large exploratory study showed.
Medscape Medical News

Алкоголь и продолжительность жизни в России идут рука об руку

Thu, 03 Oct 2019 18:25:25 +0000

Новое исследование показывает, что каждое снижение потребления алкоголя в России в течение последних 40 лет совпадает с увеличением продолжительности жизни россиян. Возможно, текущее увеличение продолжительности жизни в стране тоже имеет связь с алкоголем. Результаты исследования опубликованы в последнем номере журнала Journal of Studies on Alcohol & Drugs.

PRIORITY: Urine Test Spots Future Kidney Disease in Diabetes

Thu, 03 Oct 2019 11:05:38 +0000

Proteomic test identified patients with diabetes at high risk of kidney disease before they had detectable microalbuminuria. However, spironolactone did not mitigate the risk.
Medscape Medical News

Promising Phase 3 Results With New Oral MS Drug Ponesimod

Thu, 03 Oct 2019 10:21:36 +0000

The new drug reduced relapse rate, active lesions, and fatigue symptoms vs teriflunomide in the OPTIMUM trial.
Medscape Medical News

Emergency Abdominal Surgery Outcomes Worse for Nursing Home Residents

Thu, 03 Oct 2019 09:33:46 +0000

Older adults living in nursing homes who need emergency abdominal surgery are more likely to die or experience serious complications than counterparts living in the community, researchers say.
Reuters Health Information

Routine Infant Rotavirus Vaccination Tied to Fewer Hospitalizations

Thu, 03 Oct 2019 09:33:19 +0000

More than a decade after the rotavirus vaccine was added to the roster of routine shots recommended for all infants in the U.S., vaccination is still reducing hospitalizations for severe infections.
Reuters Health Information

Pathology Hints at Cause of Vaping-Linked Lung Injuries

Thu, 03 Oct 2019 08:06:21 +0000

The recent surge of lung injuries among users of e-cigarette products appears to be caused by chemical toxicity and not from the accumulation of lipids in the lungs, researchers say.
Medscape Medical News

FDA Clears Sacubitril/Valsartan for Children With Heart Failure

Thu, 03 Oct 2019 08:40:42 +0000

Sacubitril/valsartan is approved to treat symptomatic heart failure with systemic left ventricular systolic dysfunction in pediatric patients 1 year and older.
FDA Approvals

Ligelizumab May Improve Response in Chronic Urticaria

Thu, 03 Oct 2019 07:32:08 +0000

Early trial results suggest the investigational humanized anti-IgE monoclonal antibody ligelizumab binds to IgE with greater affinity than FDA-approved omalizumab for refractory chronic spontaneous urticaria.
Medscape Medical News

Вакцинация против ротавирусной инфекции уменьшила количество госпитализаций

Thu, 03 Oct 2019 12:06:36 +0000

У детей, получивших хотя бы одну дозу вакцины против ротавирусной инфекции, гораздо реже развиваются тяжелые формы этой болезни, у них ниже риск госпитализации.

Более 65% врачей сталкивались с тем, что их опыт противоречил принципам доказательной медицины

Thu, 03 Oct 2019 10:55:45 +0000

Коммуникационная платформа «Доктор на работе» по просьбе МедНовостей провела опрос «Медицина, основанная на доказательствах». Основной целью исследования стало определение отношения российских врачей к доказательной медицине, а также рассмотрение вопросов, вызывающих дискуссии во врачебном сообществе (народная медицина, гомеопатия, физиотерапия, вакцинация против гриппа).

Lots of Work Left for Program to Prevent Infections at US Hospitals

Thu, 03 Oct 2019 00:06:26 +0000

The States Targeting Reduction in Infections via Engagement (STRIVE) program, which aims to improve hospital infection-prevention and -control (IPC) practices, still has numerous challenges to address.
Reuters Health Information

U.S. Government Watchdog Faults DEA for Slow Response to Opioid Crisis

Thu, 03 Oct 2019 00:15:35 +0000

A U.S. government watchdog on Tuesday harshly criticized the Drug Enforcement Agency for its response to the opioid crisis, saying that amid a surge in opioid-related deaths the agency failed to use its most powerful deterrent and authorized an increase in pain pill output.
Reuters Health Information

Disparities in Preemptive Kidney Transplant Worsened After Policy Change

Thu, 03 Oct 2019 00:15:53 +0000

A new system for allocating donor kidneys implemented in 2014 slightly improved rates of preemptive transplantation overall, but worsened existing disparities in access for black and Hispanic patients and those on Medicare, new research shows.
Reuters Health Information

FDA Clears Architect Stat High-Sensitivity Troponin Test for MI

Wed, 02 Oct 2019 19:32:48 +0000

Abbott's Architect Stat troponin-I assay can identify myocardial infarction several hours sooner than standard troponin tests and improve diagnosis in women, the company says.
FDA Approvals

Bernie Sanders Treated for Blocked Artery

Wed, 02 Oct 2019 18:37:24 +0000

Democratic presidential candidate Bernie Sanders is recovering after being treated for a blocked artery.
WebMD Health News

BPA Exposure in Pregnancy Can Affect Lung Health of Children

Wed, 02 Oct 2019 16:47:32 +0000

Children of women exposed to endocrine disruptors during pregnancy can suffer respiratory effects years later, adding to existing concerns about health risks related to bisphenol A (BPA).
Medscape Medical News

PARTNER 3: Leaflet Thrombosis Often Resolves, the Questions Haven't

Wed, 02 Oct 2019 15:44:07 +0000

The CT substudy was 'mandated by the FDA to answer this question about valve thrombosis, and I think it's gone a long way toward doing that, but not completely answered it,' a trialist says.
Medscape Medical News

Oral Contraceptives Tied to Psychiatric Symptoms in Teens

Wed, 02 Oct 2019 14:50:31 +0000

Use of oral contraceptives is associated with an increased risk for depressive and other psychiatric symptoms in teenage girls, new research shows.
Medscape Medical News

Yips May Affect More Athletes Than Previously Recognized

Wed, 02 Oct 2019 12:59:17 +0000

Yips, a focal task-specific dystonia, may be more prevalent among golfers than has previously been thought, a Dutch study has found. It affects athletes in other sports and activities as well.
Medscape Medical News

Burosumab Shows Sustained Efficacy in Rare Inherited Rickets

Wed, 02 Oct 2019 12:29:55 +0000

Long-term results from a phase 3 trial show no new safety concerns, but don’t address issue of potentially life-long treatment. Hefty cost of the anti-FGF23 monoclonal antibody is also a concern.
Medscape Medical News

No Increased Mortality With Paclitaxel Balloon Angioplasty in PAD

Wed, 02 Oct 2019 11:49:40 +0000

A new patient-level aggregate dataset from the LEVANT trials shows no increase in mortality for patients treated with paclitaxel-coated balloon angioplasty at 5 years of follow-up.
Medscape Medical News

Исследование показало, какие профессии увеличивают риск диабета

Wed, 02 Oct 2019 17:33:53 +0000

Согласно данным нового шведского исследования, работники определенных профессий имеют в три раза более высокий риск диабета 2 типа. Ученые связывают это с различиями в образе жизни.

Ученые рассказали все, что известно науке о вреде вейпинга

Wed, 02 Oct 2019 17:54:17 +0000

Всесторонний обзор научных исследований, подготовленный американскими учеными, обобщил все, что знает наука о вреде электронных сигарет для легких.

U.S. FDA Issues Warning Letters to Websites Selling Illegal Opioids

Wed, 02 Oct 2019 10:06:56 +0000

The U.S. Food and Drug Administration and the Drug Enforcement Administration (DEA) jointly issued warning letters to four online networks for illegally marketing unapproved and misbranded versions of opioid medicines, the agencies said.
Reuters Health Information

A1c Swings Tied to More Diabetes Complications Long Term

Wed, 02 Oct 2019 10:10:31 +0000

"We use the newer A1c variability score, and [we] followed a lifetime trajectory from new diagnosis [of type 2 diabetes] to the [adverse] event," says the senior author in explaining the research.
Medscape Medical News

What Do You Think of Dapagliflozin for Heart Failure?

Wed, 02 Oct 2019 09:46:13 +0000

Recent trial results indicate that the diabetes drug provides substantial benefits for heart failure patients, even those without diabetes.
Medscape Reader Polls

Late 30s Could Be 'Critical Time' for Starting MS Therapy

Wed, 02 Oct 2019 07:37:04 +0000

A large study of patients with multiple sclerosis evaluated the interplay of age at disease onset and the timing of immunomodulatory therapy.
Medscape Medical News

«Мы постепенно входим в эру цифровой фармы»

Wed, 02 Oct 2019 08:49:53 +0000

С 1 октября 2019 года в России вводится обязательная маркировка препаратов программы семи высокозатратных нозологий. И с нового года эксперимент по добровольной маркировке превратится в обязательное требование для всех участников фармрынка на территории страны. Благодаря этому каждую упаковку лекарства можно будет отслеживать от момента выпуска до аптечного прилавка.

Rule Buried in Medicare Fee Schedule Could Have 'Chilling Effect'

Tue, 01 Oct 2019 15:16:04 +0000

CMS tucked a proposal for new authority to remove clinicians from Medicare into the draft 2020 physicians fee rule.
Medscape Medical News

First Black Female President-Elect at AAFP

Tue, 01 Oct 2019 15:19:12 +0000

Ada Stewart, MD, an HIV specialist in Columbia, South Carolina, enlisted in the army after 9/11 and rose to the rank of colonel.
Medscape Medical News

Fundamental Changes in Asthma Treatment Recommended by GINA

Tue, 01 Oct 2019 15:51:22 +0000

The new guidelines change recommendations for quick-relief medication on the basis of data from numerous trials. Some experts say the guidelines have not gone far enough.
Medscape Medical News

ADHD Guidelines From AAP Emphasize Team Care

Tue, 01 Oct 2019 14:00:36 +0000

In an updated clinical guideline on ADHD, the American Academy of Pediatrics stresses the need for ongoing medical care and identification of comorbid conditions such as depression and learning disorders.
Medscape Medical News

Complete Revascularization After STEMI Confers Long-term Benefit

Tue, 01 Oct 2019 14:41:30 +0000

New findings from COMPLETE show the benefit of complete revascularization on hard outcomes emerges mainly over the long-term, and is similar whether done at the index hospitalization or afterward.
Medscape Medical News

Siponimod May Delay Wheelchair Use in Secondary Progressive MS

Tue, 01 Oct 2019 14:48:51 +0000

A post hoc analysis from the EXPAND trial suggests further slowing of disability progression, but an extrapolation by the researchers out to 16 years was criticized as "speculative."
Medscape Medical News

Murder by Opioid: The Case of the Ohio Doc

Tue, 01 Oct 2019 10:05:11 +0000

An Ohio hospitalist has been charged with 25 counts of murder by opioid. What happened?
Medscape Medical News

Med Student Mental Health 'Crisis': Experts Urge Action

Tue, 01 Oct 2019 11:00:43 +0000

The conference brought together more than 350 medical school educators, students, and researchers to discuss rising rates of psychological distress among US med students — and what to do about it.
Medscape Medical News

Dulaglutide Reduces Binge Eating in Pilot Study in Diabetes

Tue, 01 Oct 2019 11:38:51 +0000

The GLP-1 agonist dulaglutide reduces binging in patients with type 2 diabetes and the eating disorder, as well as drops weight, fat mass, and A1c compared with gliclazide in a pilot study.
Medscape Medical News

CVS Suspends Sales of Zantac Brand and Generic Heartburn Drug During Safety Review

Tue, 01 Oct 2019 10:13:51 +0000

CVS Health Corp said over the weekend it will discontinue sales the popular Zantac heartburn treatment and its own generic ranitidine products from its pharmacies after traces of a known carcinogen were found in some of the products by the U.S. Food and Drug Administration.
Reuters Health Information

Could 'Liquid Biopsy' Detect Vascular Complications in Diabetes?

Tue, 01 Oct 2019 10:01:34 +0000

Using an experimental assay to analyze just a few drops of blood appears to be predictive of vascular complications in diabetes; validation studies are next and a clinical trial is planned.
Medscape Medical News

Murder by Opioid: The Case of the Ohio Doc

Tue, 01 Oct 2019 10:05:11 +0000

An Ohio hospitalist has been charged with 25 counts of murder by opioid. What happened?
Medscape Hospital Medicine

MODERATO II: Pacemaker-based Therapy Tamps Down Hypertension

Tue, 01 Oct 2019 10:07:12 +0000

It's still early days, but the novel device significantly reduced ambulatory- and office-measured systolic blood pressure in hypertensive older adults without any reported major cardiac adverse events.
Medscape Medical News

Idarucizumab Reverses Dabigatran Regardless of Renal Function

Tue, 01 Oct 2019 09:51:54 +0000

In a RE-VERSE AD subgroup analysis, idarucizumab reversed the effects of dabigatran in more than 98% of patients, regardless of renal function.
Medscape Medical News

Atrial Fibrillation Ablation: Two Concerning Trends

Tue, 01 Oct 2019 08:00:35 +0000

A trend toward more AF ablation and more aggressive procedures in the US concerns this electrophysiologist.
theheart.org on Medscape

В Минздраве отреагировали на видеообращение сотрудников НИИ детской онкологии и гематологии

Tue, 01 Oct 2019 13:05:34 +0000

Накануне представители коллектива НИИ детской онкологии и гематологии НМИЦ онкологии им. Н.Н. Блохина пригрозили массовым увольнением, если не будут выполнены их требования, среди которых смена руководства. В созданной в связи с конфликтом в НИИ комиссии Минздрава это сочли «грубым нарушением врачебной этики и деонтологии». Комиссия продолжит свою работу до 10 октября.

Ученые реабилитировали красное мясо. Доказательства его вреда оказались слабыми

Tue, 01 Oct 2019 12:17:22 +0000

Большинство людей может есть красное и даже переработанное мясо в тех же количествах, что и раньше. Несколько крупных исследований показали, что в предыдущие научные работы не дают достаточных доказательств их вреда для здоровья.

Ваша энергосберегающая стиральная машина может быть источником опасных бактерий

Tue, 01 Oct 2019 09:58:34 +0000

Ученые сообщают, что стиральная машина может быть источником патогенных бактерий, устойчивых к воздействию антибиотиков. Свое открытие они сделали в больнице, но считают, что и домашняя стиральная машина может распространять инфекцию.

FDA Panels: Concerns Persist About Montelukast Safety in Kids

Mon, 30 Sep 2019 17:10:36 +0000

Two FDA advisory panels met to address the risks for neuropsychiatric events, including suicide, in children taking montelukast; more than a dozen patients and family members shared personal stories.
Medscape Medical News

EXCEL at 5 Years: PCI, CABG 'Relatively Comparable' in LM Disease

Mon, 30 Sep 2019 17:48:03 +0000

Which of PCI or CABG for left main disease better prevented death, MI, or stroke? One prevailed early on, the other after a few years. Overall, they matched. The clinical message has shades of gray.
Medscape Medical News

Quick, Noninvasive Approach Promising for Migraine With Vertigo

Mon, 30 Sep 2019 16:08:33 +0000

Noninvasive vagus nerve stimulation provides rapid relief of vertigo and headache in patients with acute vestibular migraine, results of a small study suggest.
Medscape Medical News

Single-Payer Backing by AAFP Rebuffed

Mon, 30 Sep 2019 16:12:03 +0000

The resolution put forward by the New York chapter came amid intense focus on the subject from Democratic presidential candidates and repeated attempts to revamp the Affordable Care Act.
Medscape Medical News

Women Who Don't Speak Up at Risk for Heart Disease

Mon, 30 Sep 2019 16:54:40 +0000

There are many social and cultural factors that could be contributing to this 'silent risk factor' for cardiovascular disease, according to investigators.
Medscape Medical News

FDA OKs First Treatment for Rare Types of Vasculitis in Kids

Mon, 30 Sep 2019 14:39:45 +0000

The FDA has approved rituximab injection for granulomatosis with polyangiitis and microscopic polyangiitis in children aged 2 years or older.
FDA Approvals

Детские онкологи из НМИЦ им. Н.Н. Блохина пригрозили увольнением

Mon, 30 Sep 2019 20:56:56 +0000

Сотрудники НИИ детской онкологии и гематологии ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» грозят массовым увольнением, если не будут выполнены их требования, среди которых смена руководства. Об этом они рассказали в видеообращении, которое появилось на YouTube-канале и сайте профсоюза Альянс врачей.

Disappointment Over Immunotherapy in Mesothelioma

Mon, 30 Sep 2019 13:49:16 +0000

Despite achieving better response rates in the second-line treatment of malignant pleural mesothelioma, pembrolizumab did not improve survival over chemotherapy in a phase 3 trial.
Medscape Medical News

Здоровье сердца: профилактика, профилактика и снова профилактика

Mon, 30 Sep 2019 19:16:04 +0000

Двадцать девятого сентября отмечался Всемирный день сердца, цель которого – привлечь внимание к самой распространенной причине смертности и различным формам профилактики сердечно-сосудистых заболеваний. Существенный вклад в смертность от ССЗ вносят рецидивы и осложнения сердечно-сосудистых событий, реабилитация после которых в нашей стране практически не развита.

FDA OKs Canagliflozin to Curtail Diabetic Kidney Disease

Mon, 30 Sep 2019 12:33:21 +0000

Results of CREDENCE lead to FDA approval for canagliflozin to slow kidney disease progression and reduce the risk of heart failure hospitalization in adults with type 2 diabetes.
FDA Approvals

MCI, Heavy Drinking a Hazardous Cocktail?

Mon, 30 Sep 2019 12:41:47 +0000

The combination of mild cognitive impairment (MCI) and heavy drinking is associated with an increased risk for progression to dementia, new research shows.
Medscape Medical News

No Bone Benefits Seen With High-Dose Vitamin D in Healthy Cohort

Mon, 30 Sep 2019 10:59:55 +0000

Long-term use of daily high-dose vitamin D shows no improvements in bone health or reductions in falls versus placebo, in new analyses of the VITAL trial in generally healthy middle-aged individuals.
Medscape Medical News

COAPT at 3 Years: MitraClip Benefits Persist, Crossovers Profit

Mon, 30 Sep 2019 10:35:40 +0000

Data on patients who cross over, even after years of delay, are both reassuring and highlight the fundamental question of who should undergo repair and when.
Medscape Medical News

Know-How About New CAR-T Cell Therapies Shifting

Mon, 30 Sep 2019 09:00:48 +0000

Research is coming in quickly and is continuously changing, care teams with experience with the novel treatments caution, as they describe the effectiveness and toxicities of the drugs.
Medscape Medical News

Физическая усталость утомляет мозг и может приводить к неправильным решениям

Mon, 30 Sep 2019 15:11:15 +0000

Чрезмерная физическая нагрузка утомляет не только тело, но и мозг. Ученые обнаружили, что избыток упражнений может приводить и к психическому утомлению, что влияет на принятие решений.

Новые лекарства против рака часто менее эффективны и дороже старых

Fri, 27 Sep 2019 19:44:42 +0000

Многие новые лекарства против рака дают пациентам совсем немного пользы, если сравнить их с методами лечения, которые существовали ранее. Согласно двум новым исследованиям, представленным на конгрессе Европейского общества медицинской онкологии (ESMO), новые препараты редко соответствуют своей высокой цене.

Ученые нашли связь между риском рака простаты и искусственным оплодотворением

Mon, 30 Sep 2019 08:12:25 +0000

У мужчин, ставших отцами при помощи искусственного оплодотворения, по-видимому, выше риск рака предстательной железы по сравнению с мужчинами, ставшими отцами естественным образом. Полученные учеными данные свидетельствуют о том, что этим мужчинам следует пройти обследование на рак простаты,

FLAURA Establishes Osimertinib as 1L Therapy in EGFRm NSCLC

Sun, 29 Sep 2019 11:25:52 +0000

The final survival data from FLAURA establishes osimertinib as front-line therapy for patients with EGFR-mutated NSCLC. Give the best therapy first, experts say.
Medscape Medical News

SCOPE I: Acurate Neo Takes Beating Against SAPIEN 3

Sat, 28 Sep 2019 18:11:11 +0000

The investigational device missed its primary safety and efficacy noninferiority endpoint, but experts were not ready to concede defeat, suggesting technological refinements may resolve its shortcomings.
Medscape Medical News

Experience, High Volume Improve Mitral Valve Procedural Outcomes

Sat, 28 Sep 2019 17:23:38 +0000

Findings from two registry studies show that operator experience improves success with MitraClip, and high hospital and surgeon volume boost outcomes in surgical mitral valve repair.
Medscape Medical News

AUGUSTUS: Best Benefit With Apixaban, P2Y12 Inhibitor Dual Therapy

Sat, 28 Sep 2019 17:51:37 +0000

A new analysis from the AUGUSTUS trial found that apixaban plus a P2Y12 inhibitor without aspirin reduced bleeding and hospitalization vs VKA regimens in ACS patients with AF.
Medscape Medical News

Mitral Valve-in-Valve Replacement Upheld in High-Risk Patients

Sat, 28 Sep 2019 16:48:48 +0000

'The data support this as the standard of care for high-risk patients' with failed mitral bioprosthesis, says a researcher. Observers are cautious, but a valve expert says, 'the results are fantastic.'
Medscape Medical News

Could All Patients with Advanced NSCLC Go Chemo-Free?

Sat, 28 Sep 2019 13:54:53 +0000

Results from CheckMate 227 suggest that combination nivolumab and ipilimumab may eliminate the need for chemotherapy in advanced NSCLC, regardless of PD-L1 status.
Medscape Medical News

One in Two Patients With Metastatic Melanoma Alive After 5 Years

Sat, 28 Sep 2019 12:13:10 +0000

With the combination of ipilimumab and nivolumab, 50% of patients are still alive after 5 years, a survival rate remarkably higher than that seen with either agent alone.
Medscape Medical News

First-line Immunotherapy Still Elusive in Advanced Liver Cancer

Sat, 28 Sep 2019 10:50:10 +0000

First-line immunotherapy remains elusive for patients with hepatocellular carcinoma (HCC), but early results look good for a combination with bevacizumab.
Medscape Medical News

Skipping Radiotherapy After Surgery for Prostate Cancer

Sat, 28 Sep 2019 09:05:00 +0000

New results suggest that many men could skip radiotherapy straight after surgery, and be followed with observation and early salvage radiotherapy.
Medscape Medical News

U.S. CDC Recommends Against Using Vapes With Marijuana Ingredient

Fri, 27 Sep 2019 21:45:04 +0000

People should stop using e-cigarettes, especially those with marijuana ingredient tetrahydrocannabinol (THC), U.S. public health officials recommended on Friday, as an investigation into illnesses and deaths related to vaping deepens.
Reuters Health Information

Feds Crack Down on Physicians, Others in $2.1B Genetic Testing Scam

Fri, 27 Sep 2019 21:36:16 +0000

U.S. federal agents raided genetic testing laboratories, and 35 people were criminally charged in four states in a crackdown on genetic testing fraud that officials said on Friday caused $2.1 billion in losses to federal healthcare insurance programs.
Reuters Health Information

Class Action Lawsuit Against ABIM Dismissed

Fri, 27 Sep 2019 18:02:50 +0000

A federal court has said that ABIM has the right to require internists to recertify; any harm physicians suffer if they fail to maintain certification can't be blamed on the board.
Medscape Medical News

Bad News for Chocolate Lovers: It May Not Help Your Vision

Fri, 27 Sep 2019 17:08:54 +0000

In disappointing news for chocolate lovers, researchers have found that contrary to an earlier report, eating dark chocolate will not improve your vision.
Reuters Health Information

Hemiarthroplasty Comparable to Total Hip Surgery for Femoral Neck Fracture - Study

Fri, 27 Sep 2019 17:05:27 +0000

Hemiarthroplasty (HA) improves function and quality of life just as effectively as total hip arthroplasty (THA) in patients with displaced femoral neck fractures who were independently ambulatory before the fracture, the largest study ever done on hip fracture surgery has concluded.
Reuters Health Information

Resolute Onyx as Good as BioFreedom in High-Bleeding-Risk Patients

Fri, 27 Sep 2019 15:56:17 +0000

The device was safe and effective in complex high-bleeding-risk patients receiving 1-month DAPT in the Onyx ONE trial, but whether that duration is optimal remains unclear.
Medscape Medical News

More Glucocorticoid, Not LABA, May Control Black Kids' Asthma

Fri, 27 Sep 2019 16:42:43 +0000

Researchers report that some black children respond quite differently to treatment escalation than other racial/ethnic groups -- in a way that could change clinical practice.
Medscape Medical News

FDA Approves Daratumumab Combo for New First-Line Use

Fri, 27 Sep 2019 16:55:29 +0000

The drug is now approved in combination with three other agents for newly diagnosed patients with multiple myeloma who are eligible for autologous stem cell transplant.
FDA Approvals

Philip Morris and Altria Ditch Merger Talks as Juul Faces Crisis

Thu, 26 Sep 2019 22:05:32 +0000

Tobacco giants Philip Morris International and Altria Group have scrapped merger talks as Altria-backed e-cigarette maker Juul Labs sank deeper into crisis and said it would suspend advertising in the United States.
Reuters Health Information

Afghanistan's Taliban Lifts Ban on World Health Organization

Fri, 27 Sep 2019 07:34:55 +0000

Afghanistan's Taliban insurgency has lifted a ban on World Health Organization activities in areas the militants control, a spokesman for the Islamist group said, reversing a stance that had been complicating efforts to eradicate polio.
Reuters Health Information

Heart Health After Hot Flashes a 'Wake-up Call'

Fri, 27 Sep 2019 15:01:12 +0000

Vasomotor symptoms might actually signal problems in women's underlying health, new research indicates.
Medscape Medical News

Air Pollution Tied to Increased Psychiatric ED Visits in Kids

Fri, 27 Sep 2019 14:15:30 +0000

Short-term exposure to ambient air pollution was associated with an increase in emergency department visits for psychiatric symptoms in children.
Medscape Medical News

Drug Co Admits to Kickback Scheme Involving Seniors and Nuedexta

Fri, 27 Sep 2019 14:16:58 +0000

Avanir Pharmaceuticals has agreed to pay more than $95 million to resolve allegations of kickbacks and other charges related to 'false and misleading' off-label marketing of its drug Nuedexta.
Medscape Medical News

Second Generic Zantac Recall Due to Contamination Concerns

Fri, 27 Sep 2019 11:37:22 +0000

Apotex Corp has voluntarily recalled all pack sizes and formats of ranitidine tablets in the US on a 'precautionary basis' after a probable carcinogen was found in other generic Zantac products.
News Alerts

Новые лекарства против рака часто менее эффективны и дороже старых

Fri, 27 Sep 2019 19:44:42 +0000

Многие новые лекарства против рака дают пациентом совсем немного пользы, если сравнить их с методами лечения, которые существовали ранее. Согласно двум новым исследованиям, представленным на конгрессе Европейского общества медицинской онкологии (ESMO), новые препараты редко соответствуют своей высокой цене.

Solo Aspirin After 3 Months DAPT Safe in High-Bleed-Risk Patients

Fri, 27 Sep 2019 12:03:29 +0000

Those who went from two to one antiplatelet 3 months after stenting, many on chronic oral anticoagulation, didn't pay with more MIs or stent thrombosis over 15 months in the EVOLVE Short DAPT study.
Medscape Medical News

FDA Clears Novel 'Recharge-Free' Device for Chronic Pain

Fri, 27 Sep 2019 12:14:41 +0000

Abbott's Proclaim XR platform utilizes the company's low energy BurstDR stimulation waveform to provide effective pain relief without the hassle of recharging for up to 10 years.
FDA Approvals

Doctors Clash Over NP, PA Say in Physician Privileges

Fri, 27 Sep 2019 12:39:48 +0000

'Docs should be credentialing docs,' delegates heard here at the American Academy of Family Physicians Congress. But some delegates say they welcome input from nonphysician clinicians.
Medscape Medical News

Количество поражений легких, связанных с вейпом, увеличилось на 52%

Fri, 27 Sep 2019 18:09:49 +0000

Сейчас CDC говорит о 805 заболевших. На прошлой неделе эта цифра составляла 530 случаев, то есть их количество увеличилось на 52%. Болезнь регистрировалась в 46 штатах и на Виргинских островах. Количество смертей от заболевания, связанного с вейпом, достигло 12, а согласно сообщению Wall Street Journal – 13.

Doctors, Nurses With Addictions Often Denied a Crucial Recovery Option

Fri, 27 Sep 2019 10:57:44 +0000

Clinical studies show medication-assisted treatment decreases the rate of relapse and overdose more than other interventions alone, but often clinicians can't get permission to take opioid agonists.
Kaiser Health News

Second Generic Zantac Recall Due to Contamination Concerns

Fri, 27 Sep 2019 11:37:22 +0000

Add-On Pimavanserin Promising for Resistant Major Depression

Fri, 27 Sep 2019 11:37:51 +0000

The novel antipsychotic led to clinically meaningful improvement in depression when added to standard antidepressant in patients with major depressive disorder in a phase 2 study.
Medscape Medical News

Strike Threat 'Withdrawn' as Kaiser, Unions Reach Tentative Deal

Thu, 26 Sep 2019 07:18:18 +0000

If the settlement is ratified, 85,000 union workers will stay on the job in six states and the District of Columbia; the union gets sweetened terms after hard bargaining.
Medscape Medical News

Sick Elderly With Diabetes Stay on Insulin -- Is This a Surprise?

Fri, 27 Sep 2019 09:57:13 +0000

Older, sicker adults with diabetes were more likely to continue taking insulin than their healthier counterparts. Although findings seem counterintuitive, there's more to it than meets the eye, says expert.
Medscape Medical News

Want to Reduce Suicides? Follow the Data -- to Medical Offices

Fri, 27 Sep 2019 10:41:02 +0000

Data from medical offices, motels and even animal shelters is being used to help inform suicide prevention programs.
Kaiser Health News

Enanta Pharma's NASH Drug Meets Mid-Stage Study Goal

Fri, 27 Sep 2019 08:15:44 +0000

Enanta Pharmaceuticals Inc said on Wednesday its drug to treat non-alcoholic steatohepatitis (NASH) met the main goal of reducing levels of elevated liver enzymes in a mid-stage study.
Reuters Health Information

Health Canada Says Four More Companies Recalling Versions of Zantac

Fri, 27 Sep 2019 08:11:45 +0000

Health Canada said on Wednesday four more companies were recalling heartburn drug ranitidine, commonly known by its brand name Zantac, after presence of a probable cancer-causing impurity was found in some of the drugs.
Reuters Health Information

Study Raises Questions About Universal Screening for ASD

Fri, 27 Sep 2019 08:41:45 +0000

A large study found that screening for autism spectrum disorder is feasible in primary care but is not very accurate; experts stress not abandoning universal screening and the need for better screening tools.
Medscape Medical News

Zoledronic Acid Reduces Periodontal Disease in Osteoporosis Patients

Fri, 27 Sep 2019 07:51:04 +0000

Once-yearly zoledronic acid helps prevent symptomatic periodontal disease in osteoporosis patients, according to industry-funded research.
Reuters Health Information

Beyond TNF Inhibitors in Ulcerative Colitis: Promising Data

Fri, 27 Sep 2019 07:32:55 +0000

Two recent studies highlight the options of alternative biologic agents and regimens for patients with ulcerative colitis who are unable to receive anti-tumor necrosis factor (TNF) therapies.
Medscape Medical News

Центр протонной терапии в Димитровграде начал принимать пациентов

Fri, 27 Sep 2019 09:14:22 +0000

Ожидается, что лечение здесь смогут ежегодно получать 1200 человек, уже до конца нынешнего года шанс на спасение получат 140 человек. Всего же потребность в самом передовом на сегодня методе лучевой терапии в России составляет 25-35 тыс. человек, из которых 2,5-3 тыс. – дети. Быстро удовлетворить эту потребность не удастся – это крайне дорогой и сложный технически метод.

TWILIGHT Hits Primary Endpoint, Alters Aspirin Post PCI

Thu, 26 Sep 2019 20:31:12 +0000

The perennial question of how soon aspirin can be dropped in dual antiplatelet therapy became more definitive, but experts caution against extrapolating results to very early aspirin discontinuation.
Medscape Medical News

New CMS Rule to Ease Admin Burden, Save Clinicians Money

Thu, 26 Sep 2019 19:19:49 +0000

The Centers for Medicare & Medicaid Services moves to let more clinicians write progress notes on psychiatric patients and to allow telephone orders for portable X-rays through omnibus rule.
Medscape Medical News

[Review] 10 years of health-care reform in China: progress and gaps in Universal Health Coverage

Thu, 26 Sep 2019 23:00:09 +0000

In 2009, China launched a major health-care reform and pledged to provide all citizens with equal access to basic health care with reasonable quality and financial risk protection. The government has since quadrupled its funding for health. The reform's first phase (2009–11) emphasised expanding social health insurance coverage for all and strengthening infrastructure. The second phase (2012 onwards) prioritised reforming its health-care delivery system through: (1) systemic reform of public hospitals by removing mark-up for drug sales, adjusting fee schedules, and reforming provider payment and governance structures; and (2) overhaul of its hospital-centric and treatment-based delivery system.

[Clinical Picture] Remarkable recovery in an infant with brain abscesses

Thu, 26 Sep 2019 23:00:09 +0000

A 6-month-old infant was brought to our hospital by his parents because they were concerned that the child's head had been getting progressively larger and that he had been refusing feeds. The parents also said that their child had a fever and was vomiting; his problems had been getting worse over the previous 2 months. The infant had no history suggestive of congenital heart disease or immunosuppression, and he had not received any vaccinations. He was born by normal vaginal delivery, and the pregnancy was uncomplicated.

[Articles] Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

Thu, 26 Sep 2019 23:00:09 +0000

There is strong evidence to suggest that planned delivery reduces maternal morbidity and severe hypertension compared with expectant management, with more neonatal unit admissions related to prematurity but no indicators of greater neonatal morbidity. This trade-off should be discussed with women with late preterm pre-eclampsia to allow shared decision making on timing of delivery.

[Articles] Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Thu, 26 Sep 2019 23:00:09 +0000

In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk.

[Articles] Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Thu, 26 Sep 2019 23:00:09 +0000

China has made substantial progress in reducing the burden of many diseases and disabilities. Strategies targeting chronic diseases, particularly in the elderly, should be prioritised in the expanding Chinese health-care system.

[Correspondence] Tribute to David Sanders from the People's Health Movement

Thu, 26 Sep 2019 23:00:09 +0000

On behalf of the People's Health Movement, we would like to pay tribute to David Sanders.

[Correspondence] Mandatory reporting and vaccination in North America

Thu, 26 Sep 2019 23:00:09 +0000

The Editorial1 about Canada's mandatory vaccination reporting plans regrettably misses the mark. The Editors confuse mandatory reporting of vaccination in school-aged children with mandatory vaccination, which is different. The policy in North America typically requires mandatory reporting, with three Canadian provinces and all 50 US states and the District of Columbia in the USA requiring either a report of certain vaccines having been administered or a signed exemption for school entry.2,3 The US states of California, West Virginia, and Mississippi are the most stringent regarding exemptions, only granting vaccine exemption on medical grounds.

[Correspondence] A medic's responsibility: a report from the Paris refugee camps

Thu, 26 Sep 2019 23:00:09 +0000

We agree with the Editors that health-care professionals have a duty to care for vulnerable populations.1 We report on the situation for refugees in France. Since the shutdown of the so-called Calais Jungle refugee camp in Calais, France, in autumn 2016, more refugees have moved to the streets of Paris.2

[Correspondence] The EAT–Lancet Commission: a flawed approach? – Authors' reply

Thu, 26 Sep 2019 23:00:09 +0000

We welcome this opportunity to clarify issues and comment on misinterpretations that have arisen since the publication of the EAT–Lancet report on healthy diets from sustainable food systems.1

[Correspondence] The EAT–Lancet Commission: a flawed approach?

Thu, 26 Sep 2019 23:00:09 +0000

The goal of the EAT–Lancet Commission report on food in the Anthropocene by Walter Willett and colleagues1 is laudable given the immediate need for action on climate change and the growing burden of non-communicable diseases on global health. Unfortunately, omissions in the documentation, together with methodological flaws in assumptions, data collection, and modelling, are substantial enough to alter the conclusions of the report.

[Correspondence] Effect of the escalating China–US trade war on health care

Thu, 26 Sep 2019 23:00:09 +0000

After the 11th round of negotiations failed to reach an agreement, the China–US trade dispute began to escalate. In addition to adding tariffs on imported goods, totalling hundreds of billions of US dollars, the dispute has expanded into the fields of technology and education and will inevitably affect the downstream health-care industry, influencing price, quality, technology, research, and education.

[Correspondence] Menopausal hormone therapy and 20-year breast cancer mortality

Thu, 26 Sep 2019 23:00:08 +0000

The Collaborative Group on Hormonal Factors in Breast Cancer has brought together the worldwide evidence on menopausal hormone therapy (MHT) and the incidence of invasive breast cancer.1 All types of MHT examined, except vaginal oestrogens, were associated with a significant excess incidence of breast cancer. Both among current users and among past users the risks increased steadily with duration of MHT use. Risks were greater for oestrogen-progestagen than for oestrogen-only preparations, and some excess risk persisted for more than a decade after cessation of use.

[Obituary] David Mark Sanders

Thu, 26 Sep 2019 23:00:08 +0000

Renowned specialist in public health and activist for global health equity. Born in Cape Town, South Africa, on Aug 5, 1945, he died of a heart attack while on holiday in Wales, UK, on Aug 30, 2019, aged 74 years.

[Perspectives] A last cup of tea

Thu, 26 Sep 2019 23:00:08 +0000

When on Nov 1, 2006, Russian ex-secret agent Alexander Litvinenko was admitted with acute abdominal pain, diarrhoea, and vomiting to hospital in London, UK, doctors did not realise that they were facing a case of poisoning with polonium-210. As described by the doctors who treated Litvinenko in The Lancet, early symptoms of polonium-210 poisoning were indistinguishable from those of a wide range of chemical toxins. When polonium-210 was finally identified as the source of the poisoning, Litvinenko's condition was desperate and he died on Nov 23.

[Perspectives] Holding a mirror up to global health

Thu, 26 Sep 2019 23:00:08 +0000

Global health is an area full of contradictions. Here are just a few. Those who most require effective and equitable health systems are least able to shape the priorities and implementation of policies made by elites in capital cities. Nearly 70% of the global health workforce are women, but the leading decision makers “in global health policy and research are still a small, closely connected network of mostly western, male, senior individuals”, according to a 2019 WHO paper on gender equity. We live on a planet with almost 8 billion people, yet there is increased concentration of power and resources in a small number of individuals and companies.

[Perspectives] Thalassaemia

Thu, 26 Sep 2019 23:00:08 +0000

In 1858 the German pathologist Rudolf Virchow described leukaemia as a disorder of white blood cell proliferation. Virchow and others observed that people with chronic leukaemia typically had enlarged spleens, and for the next 50 years or so patients with this sign might be diagnosed with “splenic anaemia”. In the early 20th century, though, this broad frame broke into several new diagnoses. One of them—thalassaemia—has been shaped by some of the most potent forces of the modern era: migration and shifting attitudes to race, molecular medicine and the pharmaceutical industry, the power of scientific medicine, and the limitations of treatment.

[Perspectives] Shuyang Zhang: pioneer in China's rare diseases programme

Thu, 26 Sep 2019 23:00:08 +0000

The day starts very early for Shuyang Zhang, Professor of Cardiology and Vice President of Peking Union Medical College Hospital (PUMCH) in Beijing, China. “I am lucky in my position to have so many diverse spheres of work as part of daily life at the hospital: liaising with leaders in clinical medicine, directors of medical education, and with lead researchers who direct our clinical trials programme”, she says. However, Zhang reserves a day each week for clinical work in cardiology and the specialty that she has helped pioneer in China over the past few years: rare diseases.

[Perspectives] The right decisions need the right voices

Thu, 26 Sep 2019 23:00:08 +0000

Community-engaged care is an essential and powerful part of high-quality health care. Its premise is that the voices of those who are impacted, who experience a condition, or who have relevant lived experiences should be considered authoritative in situations where decisions are made and human, time, or financial resources are being allocated. Similarly, the voices of scholars who represent the affected group are most powerful when they are aligned with community experiences, while providing the scientific rigor to assess needs and develop and test effective solutions.

[World Report] Cuba's doctors-abroad programme comes under fire

Thu, 26 Sep 2019 23:00:08 +0000

Disapproval of the assistance programme that sends hundreds of Cuban doctors to foreign countries has been building. Lise Alves reports.

[World Report] Congress and President Trump take on high drug prices

Thu, 26 Sep 2019 23:00:08 +0000

Proposals from the White House and Congress to lower prescription drug costs, which both rejected more than a decade ago, are making a comeback. Susan Jaffe reports.

[Comment] Offline: The false narrative of “tremendous progress”

Thu, 26 Sep 2019 23:00:08 +0000

“More women and their children are surviving today than ever before.” This statement from UNICEF last week was indisputably true. Impressively detailed reports from the UN Inter-Agency Group for Child Mortality Estimation and the UN Maternal Mortality Estimation Inter-Agency Group described “tremendous progress…over the past two decades”. 12·5 million children under-5 died in 1990. That figure fell to 5·3 million in 2018. Put another way, there were 34 000 child deaths each day in 1990 and 15 000 deaths per day in 2018.

[Comment] Orphan drug development in China: progress and challenges

Thu, 26 Sep 2019 23:00:08 +0000

On Aug 26, 2019, the National People's Congress (NPC) Standing Committee approved the new revision of the Drug Administration Law of China that allows orphan drug approval to be based on evidence from foreign clinical trials through the green channel mechanism with priority review and accelerated approval. Medical institutions can now legally purchase small amounts of urgently needed orphan drugs from overseas markets.1 This is welcome news for China's 16 million patients with rare diseases.2

[Comment] Bridging the GP gap: nurse practitioners in China

Thu, 26 Sep 2019 23:00:08 +0000

China's 2009 national health reform focused on health insurance, drugs, public health, hospitals, and primary care.1 On its tenth anniversary, evaluations of the reforms are underway.2 There has been good progress in some areas, such as medical insurance coverage through National Healthcare Security Administration. Obstacles, however, hinder progress in other areas. Primary care and large hospitals have been the most resistant to reform efforts. The Chinese Government has set the goal of achieving 300 000 general practitioners (GPs) by 2020—or two to three GPs per 10 000 population by 2020—and a net GP workforce of 700 000, or five GPs per 10 000 population by 2030.

[Comment] Healthy China 2030: an opportunity for tobacco control

Thu, 26 Sep 2019 23:00:08 +0000

The 2018 China Tobacco Survey shows progress as a result of China's concerted tobacco control efforts in the past decade. People in China are less likely to be harmed by second-hand smoke than they were in 2010, as evidenced by the decrease in second-hand smoke exposure in indoor public places such as workplaces (from 63·3% to 50·9%), government buildings (from 58·4% to 31·1%), health-care facilities (from 37·9% to 24·4%), public transport (from 34·1% to 12·9%), and restaurants (from 88·5% to 73·3%).

[Comment] China's new 4 + 4 medical education programme

Thu, 26 Sep 2019 23:00:08 +0000

2019 is the tenth anniversary of China's latest health system reform.1 Over the past decade, China has invested much time and effort in improving health-care access and equity. Most noticeably, China has expanded health insurance coverage to more than 95% of its population.2 However, gaps in health-care quality remain, and resolving these gaps will be key to realising Healthy China 2030, an important long-term national strategic plan.3

[Comment] Long-term cardiovascular health after stopping pre-eclampsia

Thu, 26 Sep 2019 23:00:08 +0000

Pre-eclampsia kills approximately 76 000 women and 500 000 babies every year.1 The mortality rate is high in low-income countries without sufficient antenatal and obstetric care. The only current available pre-eclampsia cure is delivery of the dysfunctional placenta, which sheds excessive proinflammatory substances to the maternal cardiovasculature.2,3 High-risk women, identified in the first trimester by screening of clinical risk factors4 and dysregulated placental function biomarkers,1,5 are recommended low-dose aspirin as prophylaxis against preterm pre-eclampsia.

[Comment] Ticagrelor in patients with diabetes and previous PCI

Thu, 26 Sep 2019 23:00:08 +0000

Dual antiplatelet therapy is not indicated for patients without clinically evident cardiovascular disease, whereas its duration remains controversial in patients with established stable coronary artery disease after percutaneous coronary intervention (PCI).1 Only clopidogrel, among the other P2Y12 inhibitors, has been investigated in this patient population in addition to aspirin.

[Comment] Menopausal hormones: definitive evidence for breast cancer

Thu, 26 Sep 2019 23:00:07 +0000

For some women, menopause is an easy life transition, but for others, it means sleepless nights, hot flushes, and often a decline in wellbeing. For decades, women have been prescribed synthetic versions of the hormones that are lost with ovarian functional decline, in pill form or in other formulations (eg, patches, gels, or injections), either as oestrogen alone (usually for women who have had a hysterectomy) or as an oestrogen and progesterone combination (usually for those with an intact uterus) to help mitigate some of the symptoms.

[Comment] Measuring progress in health in China and its provinces

Thu, 26 Sep 2019 23:00:07 +0000

In The Lancet, Maigeng Zhou and colleagues1 present a systematic analysis for the Global Burden of Disease Study (GBD) 2017 on mortality, morbidity, and risk factors in China and its provinces, from 1990 to 2017. Their report is, to our knowledge, the first comprehensive subnational assessment of health in the Chinese population after previous GBD China 2010 on mortality, morbidity, combined health loss, and risks at the national level2 and GBD China 2013 on mortality at the national and province level.

[Editorial] Prescribing off-label drugs for children: when will it change?

Thu, 26 Sep 2019 23:00:07 +0000

A study in Pediatrics, published on Sept 16, paints a familiar picture. Using data from the US National Ambulatory Medical Care Surveys 2006–15, Divya Hoon and colleagues show that in 44·5% of visits to office-based physicians who prescribed systemic drugs to children, these drugs were prescribed off label. Off-label prescription can be outside the approved age, weight, dose, formulation, route of administration, or indication. In this study, 74·6% of all off-label prescriptions were for an unapproved disorder for the specific drug and 17·6% were off-label by age.

[Editorial] Accountability and nuclear accidents: Fukushima verdict

Thu, 26 Sep 2019 23:00:07 +0000

On Sept 19, three former Tokyo Electric Power Company (Tepco) executives charged with negligence regarding the 2011 accident at the company's Fukushima Daiichi plant were acquitted by a Japanese court because opinion was divided over the scientific evaluations of predicted tsunamis. The decision concludes the only criminal trial connected to the disaster, which, like Chernobyl, was classified as Level 7 on the International Nuclear Event Scale.

[Editorial] China's health-care reform: an independent evaluation

Thu, 26 Sep 2019 23:00:07 +0000

When The Lancet visited the National Health Commission of China in 2018, Ma Xiaowei, the minister of health, said he would welcome independent assessment of the progress of China's health reforms. Today, The Lancet dedicates the ninth China-themed issue to evaluate progress of China's health-care reform since 2009, which coincides with the fifth Lancet–Chinese Academy of Medical Sciences (CAMS) Health Conference, held in Chengdu on Oct 19–20.

FDA Further Expands Approval of HCV Combo Drug Mavyret

Thu, 26 Sep 2019 18:39:57 +0000

Mavyret is the first 8-week treatment approved for all treatment-naive adult and certain pediatric patients with any hepatitis C virus genotype, both without cirrhosis and with compensated cirrhosis.
FDA Approvals

Liberian Hospital Patients Turned Away as Medical Strike Bites

Thu, 26 Sep 2019 16:55:05 +0000

A medical workers' strike in Liberia has paralyszed the country's already faltering healthcare system, leaving its biggest hospitals in disarray and thousands of patients without care.
Reuters Health Information

Canberra Becomes First Australian City to Legalize Marijuana for Personal Use

Thu, 26 Sep 2019 16:58:33 +0000

Australia's capital city of Canberra will become the first in the country to legalize the possession, use and cultivation of small amounts of cannabis following a vote on Wednesday.
Reuters Health Information

'Provocative' Results With Stem Cells in Progressive MS

Thu, 26 Sep 2019 16:42:40 +0000

A new trial of autologous mesenchymal stem cells in progressive MS has shown significant benefits vs placebo in several measures of disability.
Medscape Medical News

Asthma and Anxiety a Dangerous Mix in Kids

Thu, 26 Sep 2019 16:43:16 +0000

Children with asthma and comorbid depression or anxiety were significantly more likely to present to the emergency department than those with asthma alone.
Medscape Medical News

Ученые рассказали, какие напитки лучше восполняют потерю жидкости

Thu, 26 Sep 2019 18:11:03 +0000

Простая вода – хороший, но не самый лучший напиток для поддержания количества жидкости в организме (гидратации), согласно исследованию, проведенному в Шотландском Сент-Эндрюсском университете. В работе сравнивалось восполнение дефицита воды при употреблении различных напитков. Результаты исследования опубликованы в American Journal of Clinical Nutrition.

Insulin Degludec Fails to Best Glargine in CONCLUDE Study

Thu, 26 Sep 2019 14:55:07 +0000

Overall hypoglycemic episodes didn't differ in a head-to-head trial of the two second-generation basal insulin analogs, but both nocturnal and severe episodes were reduced with degludec.
Medscape Medical News

E-Cigarettes Are Harmless, Say 1 in 5 Young Adults

Thu, 26 Sep 2019 15:01:12 +0000

A new national poll reveals what Americans of all ages think about e-cigarettes, including whether or not they can cause harm.
Medscape Medical News

Depression With Dystonia Predicts Lower Quality of Life

Thu, 26 Sep 2019 14:22:06 +0000

Depression is the strongest long-term predictor of health-related quality of life for patients with isolated dystonia, a new study shows.
Medscape Medical News

Unique 'Signatures' in Baby Teeth Identify Autism, ADHD

Thu, 26 Sep 2019 13:46:03 +0000

Metabolic "signatures" in baby teeth can distinguish ADHD from autism as well as cases in which both neurodevelopmental disorders are present, early research suggests.
Medscape Medical News

Ученые рассказали, какие напитки лучше восполняют потерю жидкости

Thu, 26 Sep 2019 18:11:03 +0000

Простая вода – хороший, но не самый лучший напиток для гидратации поддержания количества жидкости в организме (гидратации), согласно исследованию, проведенному в Шотландском Сент-Эндрюсском университете. В работе сравнивалось восполнение дефицита воды при употреблении различных напитков. Результаты исследования опубликованы в American Journal of Clinical Nutrition.

Lithotripsy Is a Blast for Tough Coronary Calcium: Disrupt-CAD 2

Thu, 26 Sep 2019 11:49:42 +0000

Heavily calcified coronary lesions yield easily to stents if they've first been shattered by blasts of acoustic energy from an intravascular lithotripsy balloon catheter, early experience suggests.
Medscape Medical News

Blood Pressure Med May Improve Cognitive Impairment in Autism

Thu, 26 Sep 2019 10:02:16 +0000

There are currently no FDA-approved drugs to improve social and cognitive impairments in autism. This study suggests that using beta-blockers might be a promising approach.
Medscape Medical News

Novel DBS Benefits Parkinson's Patients Over Two Years

Thu, 26 Sep 2019 10:04:10 +0000

A rechargeable deep brain stimulator with a multicontact lead allowing precise current targeting shows sustained benefit in a large proportion of patients with Parkinson's, in 2-year INTREPID results.
Medscape Medical News

Red Blood Cell Width Predicts Hip Fracture Risk

Thu, 26 Sep 2019 10:14:31 +0000

Red blood cell width, routinely available in full blood counts, is associated with likelihood of hip fracture and could offer a good way to identify high risk patients at no cost, say researchers.
Medscape Medical News

"ВКонтакте" предупреждает пользователей о вреде антипрививочных сообществ

Thu, 26 Sep 2019 16:29:00 +0000

Социальная сеть «ВКонтакте» предприняла меры против распространения ложной информации о вакцинации. Теперь каждый желающий вступить в антипрививочное сообщество может получить от соцсети предупреждение о его опасности для здоровья.

An ACC First: Health Policy Statement on Equal Pay, Opportunity

Thu, 26 Sep 2019 08:43:35 +0000

Compensation and opportunity equity are 'critical' to the health and future of the cardiovascular workforce, the ACC says in policy statement.
Medscape Medical News

Strike Threat 'Withdrawn' as Kaiser, Unions Reach Tentative Deal

Thu, 26 Sep 2019 07:18:18 +0000

If the settlement is ratified, 85,000 union workers will stay on the job in six states and the District of Columbia; the union gets sweetened terms after hard bargaining.

"Вейпите ли вы?" У пульмонологов появился новый вопрос к пациентам

Thu, 26 Sep 2019 09:58:58 +0000

В связи со всплеском распространенности заболевания, связанного с вейпом, в США у врачей стал появляться новый вопрос в рутинном расспросе пациента. Доктора, в частности пульмонологи, все чаще спрашивают у пациентов вейпят ли они, то есть, пользуются ли электронными сигаретами. Об этом сообщает издание StatNews, репортеры которого пообщались с врачами.

Небольшое количество орехов в диете поможет не набрать лишний вес

Thu, 26 Sep 2019 08:33:18 +0000

Увеличение потребления орехов всего на 14 грамм в день связано с замедлением набора веса и меньшим риском ожирения, говорится в новом американском исследовании. Замена нездоровой пищи, такой как переработанное мясо и чипсы, на небольшое количество орехов препятствует постепенному увеличению веса, которое часто сопровождает процесс старения.

Responsive Caregivers May Raise Kids With Better Language Skills

Thu, 26 Sep 2019 01:40:26 +0000

Mothers who are more responsive and warmer in their interactions with their kids may have children with better language skills, especially in low-income households, a small study suggests.
Reuters Health Information

Youngest Kids in Class More Often Diagnosed With ADHD, Learning Disabilities

Thu, 26 Sep 2019 01:40:22 +0000

Kids who are younger than most of their classmates may be more likely to be diagnosed with learning disabilities, depression, and attention deficit hyperactivity disorder (ADHD) than older students in their grade, a UK study suggests.
Reuters Health Information

Home-based Aerobic Exercise Benefits Patients With Parkinson's

Thu, 26 Sep 2019 01:41:28 +0000

A home-based, remotely supervised program of aerobic exercise improves motor scores in patients with Parkinson's disease, researchers in the Netherlands report.
Reuters Health Information

Adverse Health Effects From Hurricanes May Be Long-lasting

Thu, 26 Sep 2019 01:42:53 +0000

Long after the winds have died down and the flooding has subsided, huge hurricanes like Katrina may be shortening people's lives, especially when it comes to seniors with chronic diseases like diabetes, new research suggests.
Reuters Health Information

China May Roll Out E-cigarette Rules Amid Global Vaping Backlash: State Media

Thu, 26 Sep 2019 01:48:09 +0000

China, the world's largest tobacco market, may introduce rules for the e-cigarette industry as early as next month amid growing health concerns and reports that some products contain toxic elements, state media reported.
Reuters Health Information

France May Face Sperm Shortage Under Macron Plan to Ease IVF Rules

Thu, 26 Sep 2019 01:53:21 +0000

France risks a shortage of frozen sperm if lawmakers approve new legislation that allows single women and lesbian couples access to in-vitro fertilisation (IVF) and abolishes the right of sperm and egg donors to keep their identities secret, clinicians said.
Reuters Health Information

Chronic Diarrhea Linked to Obesity, Independently of Diet

Wed, 25 Sep 2019 16:13:52 +0000

Obese and severely obese adults were significantly more likely to report having chronic diarrhea than their peers who were of normal weight, regardless of their food intake, a study found.
Medscape Medical News

Unlocking the Mystery of Prodromal MS With a Key Biomarker

Wed, 25 Sep 2019 16:49:00 +0000

The promise of serum neurofilament light chain to diagnose multiple sclerosis continues to evolve, with new evidence supporting a role in identifying presymptomatic disease.
Medscape Medical News

Text Reminders Help Patients With RA Sit Less

Wed, 25 Sep 2019 15:53:52 +0000

Patients with RA who had three counseling sessions and weekly text reminders reduced sitting time by nearly an hour per day and durably improved fatigue, pain, and function.
Medscape Medical News

Push to Expand State Medical Licenses, Widen Practices

Wed, 25 Sep 2019 14:37:23 +0000

Physicians burdened by having to apply for licenses in several states when their work or telemedicine practice crosses state lines got affirmation this week that efforts are underway to change that.
Medscape Medical News

Multimodal Balance Training Improves Freezing of Gait in PD

Wed, 25 Sep 2019 14:57:11 +0000

Multimodal balance training with rhythmic cues improved balance and freezing of gait with persistent benefit in Parkinson's patients, a well-controlled study has shown.
Medscape Medical News

Minorities More Likely Than Whites to Have Diabetes at Normal BMI

Wed, 25 Sep 2019 12:56:13 +0000

"Along with screening patients who are overweight and obese, minorities should probably be screened even if they have a normal BMI, particularly as they get older," says the senior author.
Medscape Medical News

Headache After Childbirth Epidural a Red Flag for Brain Bleed

Wed, 25 Sep 2019 13:22:54 +0000

Headaches in women who have had an epidural during childbirth may be a red flag for an increased risk of subdural hematoma.
Medscape Medical News

Aid in Dying Debate Reignites at AAFP

Wed, 25 Sep 2019 13:28:01 +0000

The dispute centered this time on the difference between medical aid in dying and physician-assisted suicide, and two proposed resolutions drew impassioned testimony at the Congress of Delegates.
Medscape Medical News

Omega-3s Recommended as Adjunctive Therapy for Major Depression

Wed, 25 Sep 2019 11:10:36 +0000

A clinical practice guideline recommends that clinicians consider omega-3 fatty acids as adjunctive therapy for patients with major depression.

Bariatric Surgery in Obese Type 1 Diabetes Has Pros, Cons

Wed, 25 Sep 2019 11:15:44 +0000

Large registry study in Sweden sheds light on risks and benefits of bariatric surgery in patients with type 1 diabetes, stresses it's important to evaluate potential candidates on a case-by-case basis.
Medscape Medical News

US Diet Slowly Improving, Study Suggests

Wed, 25 Sep 2019 10:06:08 +0000

Healthy Eating Index scores in the United States improved slightly from 1999 through 2016, with the estimated energy contribution from carbohydrates decreasing, but some problems persist.
Medscape Medical News

'A Bad Result': HbA1c Targets Missed in Most With Type 1 Diabetes

Wed, 25 Sep 2019 10:12:56 +0000

Worldwide, only one in five patients use insulin pumps and/or CGM, and half aren't titrating their own insulin doses.
Medscape Medical News

Have FDA Warnings Affected Your Prescribing Habits?

Wed, 25 Sep 2019 10:30:14 +0000

Sometimes safety risks emerge after a drug is already on the market.
Medscape Reader Polls

Федермессер: «Социальные гостиницы не решат проблемы проживания больных детей вблизи клиник»

Wed, 25 Sep 2019 14:05:30 +0000

Корень проблемы – в отсутствии медицинской помощи по месту проживания людей, считает учредитель Фонда «Вера». Надо развивать региональную медицину, приближая ее к пациентам, а не снимать им жилье в Москве. Вернуться к обсуждению этой темы заставила очередная жалоба жильцов столичной многоэтажки на использование соседней квартиры в качестве гостиницы для семей онкобольных детей.

Make Hormonal Contraceptives Available OTC, ACOG Says

Wed, 25 Sep 2019 07:40:31 +0000

Updated guidance from the ACOG advocates making vaginal rings, the contraceptive patch, and depot medroxyprogesterone acetate available for purchase over the counter along with oral contraceptives.
Medscape Medical News

Онкохирурги НМИЦ радиологии удалили пациенту забрюшинную опухоль весом около 20 кг

Wed, 25 Sep 2019 13:41:47 +0000

Всю брюшную полость пациента занимали множественные опухолевые узлы различного размера, которые сдавливали и оттесняли жизненно важные органы. В ходе радикальной операции хирурги удалили гигантскую неорганную опухоль и опухолевый тромб из нижней полой вены. При этом все соседние органы удалось сохранить. И, как считают врачи, теперь пациент сможет вернуться к полноценной жизни.

Треть случаев рака молочной железы можно предупредить изменением образа жизни

Wed, 25 Sep 2019 08:20:28 +0000

Один из трех случаев рака молочной железы можно предупредить, изменив привычки и образ жизни. Для этого нужно контролировать вес, поддерживать физическую активность, следить за питанием, не злоупотреблять алкоголем. Доклад о профилактике заболевания прозвучал на ежегодной конференции Североамериканского общества по изучению менопаузы в Чикаго.

California Federal Prosecutors Conducting Criminal Probe Into Juul - WSJ

Tue, 24 Sep 2019 22:50:37 +0000

Federal prosecutors in California are conducting a criminal probe into e-cigarette maker Juul Labs Inc, the Wall Street Journal reported on Monday, citing people familiar with the matter.
Reuters Health Information

Ocrelizumab Reduces Wheelchair Use in Primary Progressive MS

Tue, 24 Sep 2019 20:13:38 +0000

Latest data from the ONTARIO study show that, after 6.5 years of follow-up, patients who started on ocrelizumab earlier are less likely to progress to the point where they need a wheelchair.
Medscape Medical News

Dr Stuart Levy, 'Father of Antibiotic Stewardship,' Dies at 80

Tue, 24 Sep 2019 20:22:26 +0000

A beloved physician and researcher who fought the status quo to foster antibiotic stewardship, Levy dedicated his life to warning the world about the dangers of misuse.
Medscape Medical News

FDA Approves Vaccine Against Smallpox, Monkeypox

Tue, 24 Sep 2019 18:45:22 +0000

The approval is in part intended to protect against the potentially devastating consequences of intentional release of the smallpox virus, and the vaccine will be included in the Strategic National Stockpile.
FDA Approvals

US Gathers 350 Global Commitments vs Antibiotic Resistance

Tue, 24 Sep 2019 17:12:07 +0000

Global commitments to fight antibiotic resistance have come from governments, pharmaceutical and health insurance companies, medical professionals, healthcare systems, and the food industry.
Medscape Medical News

No SGLT-2 Inhibitor Echo Benefit in Preserved-EF HF, Diabetes

Tue, 24 Sep 2019 16:13:03 +0000

Any reverse-remodeling effects from the drugs may not apply to people with diabetes and heart failure with preserved ejection fraction, a group that hasn't been well studied, a small study suggests.
Medscape Medical News

Measles Threat Rages Elsewhere After New York City Outbreak

Tue, 24 Sep 2019 16:35:12 +0000

Although measles was eliminated in the United States in 2000, the recent outbreak in New York could put that status in jeopardy.
Medscape Medical News

Newark Officials Say Temporary Filters 97% Successful in Removing Lead From Water

Tue, 24 Sep 2019 15:09:07 +0000

Preliminary lead testing in New Jersey's largest city, where old pipes are blamed for leaching the toxic metal into drinking water, show temporary filters are at least 97% successful in supplying clean water to residents, officials said on Monday.
Reuters Health Information

Health Care Investment Needed to Curb Out-of-Pocket Spending - WHO

Tue, 24 Sep 2019 15:19:51 +0000

Governments must boost spending on primary health care by at least an additional 1 percent of their gross domestic product to widen coverage and stop impoverishing patients, the World Health Organization (WHO) said on Sunday.
Reuters Health Information

French Researchers Building Massive New Scanner to Tackle Brain Disease

Tue, 24 Sep 2019 15:26:23 +0000

French researchers are developing what they say will be the most powerful magnetic resonance imaging (MRI) scanner in the world, which will use a supermagnet the weight of a blue whale and should allow earlier diagnosis of diseases such as Parkinson's.
Reuters Health Information

Extra Protein Boosts Muscle With Resistance Training, but Only Slightly

Tue, 24 Sep 2019 14:08:35 +0000

Extra protein from food or supplements does lead to increases in strength and muscle, but not as much as some might hope, researchers say.
Reuters Health Information

Sandoz Recalls Generic Zantac in US in Wake of Sales Halt

Tue, 24 Sep 2019 14:40:01 +0000

The recall of Sandoz ranitidine 150 mg and 300 mg capsules includes all quantities and lots of unexpired product and follows confirmed contamination with a likely human carcinogen in some product batches.
News Alerts

Бедность ускоряет старение

Tue, 24 Sep 2019 20:25:57 +0000

Генетика, образ жизни и окружающая среда - все эти факторы, так или иначе, влияют на то, когда и как мы стареем. Тем не менее, финансовое положение тоже играет важную роль. Ученые из Копенгагенского университета обнаружили, что четыре и более года жизни ниже порога бедности во взрослом возрасте играют существенную роль в проявлении признаков старения в организме.

Hypertension Risk Increased in Kidney Donors

Tue, 24 Sep 2019 13:40:32 +0000

Kidney donors face a higher risk of developing hypertension, according to findings from the ongoing WHOLE-Donor study.
Reuters Health Information

Canada's Trudeau Pledges Major Drug Plan Boost After Blow From Blackface Photos

Tue, 24 Sep 2019 13:56:12 +0000

Canadian Prime Minister Justin Trudeau pledged on Monday to create a national prescription drug plan if re-elected, moving back on the offensive after blackface photos of him emerged last week and hurt his campaign.
Reuters Health Information

Calcium in Food or Supplement Is Safe in Postmenopausal Women

Tue, 24 Sep 2019 13:00:44 +0000

Healthy postmenopausal women randomized to dietary or supplemental calcium show no negative effects in key vascular measures.
Medscape Medical News

Anemia in Early Pregnancy Linked to Autism, ADHD in Kids

Tue, 24 Sep 2019 13:38:19 +0000

Iron deficiency anemia in early pregnancy is tied to an increased risk of neurodevelopmental disorders, including intellectual disability, in kids.
Medscape Medical News

Deep Brain Stimulation Offers New Hope for Severe Tinnitus

Tue, 24 Sep 2019 12:08:24 +0000

Bilateral deep brain stimulation of the caudate nucleus is safe and effective for patients with severe tinnitus for whom conventional treatments have failed, new research suggests.
Medscape Medical News

IVF Associated With Higher Risk of Gestational Diabetes

Tue, 24 Sep 2019 12:12:31 +0000

Assisted reproduction is associated with an increased risk of gestational diabetes compared with mothers who conceive naturally, even after controlling for typical confounding factors.
Medscape Medical News

No Change in Radiation Oncologists' Interaction With Industry

Tue, 24 Sep 2019 11:04:20 +0000

The number of radiation oncologists interacting with industry has not significantly changed despite the inception of Open Payments.
Medscape Medical News

Parental Smoking Predicts Atrial Fibrillation Risk in Adult Offspring

Tue, 24 Sep 2019 11:10:48 +0000

Although a large proportion of cardiovascular disease is attributed to modifiable risk factors, little has been published on the effects of secondhand smoke exposure on AF later in life.
Medscape Medical News

Diabetes Activist Arrested at Vigil on Insulin Pricing Crisis

Tue, 24 Sep 2019 10:52:56 +0000

Advocates of #insulin4all continue to pressure manufacturers and legislators to take action against the extortionate cost of insulin in the United States, with a vigil and staged arrest outside Lilly headquarters.
Medscape Medical News

Novo Nordisk Targets Bigger Slice of Diabetes Market With New Tablet

Tue, 24 Sep 2019 09:24:07 +0000

Danish drugmaker Novo Nordisk is aiming for a big slice of the multibillion-dollar diabetes market with a new pill, approved by U.S. authorities on Friday, that caters for patients with an aversion to needles.
Reuters Health Information

CIED Infections Have Risen Over the Past 2 Decades

Tue, 24 Sep 2019 08:55:34 +0000

Although the overall incidence of CIED infections is low for new implants, the risk for infection is significantly increased for generator replacement and device upgrade procedures.
Medscape Medical News

Игнорирование направления на обследование при подозрении на рак увеличивает риск смерти

Tue, 24 Sep 2019 12:55:31 +0000

По данным нового крупного британского исследования, пациенты, которые игнорируют срочное направление на обследование по поводу подозрения на рак, на 12% чаще умирают в течение 12 месяцев после установления диагноза.

Эксперты впервые разработали руководство по выбору напитков для детей младшего возраста

Tue, 24 Sep 2019 09:01:38 +0000

Ведущие медицинские и диетологические организации США впервые разработали набор всесторонних научно обоснованных рекомендаций по выбору напитков для здоровых детей от рождения до 5 лет.

Obesity, Drinking and Unhealthy Diet Add to Gout Risk

Mon, 23 Sep 2019 20:59:40 +0000

Behavior changes could potentially reduce a large part of the risk for developing gout, a U.S. study suggests.
Reuters Health Information

Sleep-disordered Breathing Tied to Multiple Causes in Young Children

Mon, 23 Sep 2019 21:03:11 +0000

Both early- and late-onset sleep-disordered breathing (SDB) are associated with various conditions that cause pharyngeal dysfunction in young children, a retrospective study reveals
Reuters Health Information

Too Few Pregnant Women Get Exercise Advice From Doctors, Study Finds

Mon, 23 Sep 2019 21:03:30 +0000

Only one in two pregnant women in an Australian survey said their healthcare practitioner had advised them about exercising, and more than half of these women had to raise the topic themselves, researchers found.
Reuters Health Information

Anemia in Early Pregnancy Linked With Risk for Neurodevelopmental Disorders

Mon, 23 Sep 2019 21:05:03 +0000

Children born to mothers with iron-deficiency anemia early in pregnancy may be at higher risk for neurodevelopmental disorders, a new study suggests.
Reuters Health Information

Abortion Declines in US Not Attributable Solely to Clinic Closures

Mon, 23 Sep 2019 20:52:22 +0000

Abortion rates in the U.S. have continued to fall, and the decline isn't completely explained by abortion clinic closures, according to an Abortion Provider Census (APC) released this week by the Guttmacher Institute.
Reuters Health Information

Sheep Help Researchers Study DNA-based Antibody Administration

Mon, 23 Sep 2019 20:52:56 +0000

Studies in sheep are assisting clinical translation of DNA-based administration of monoclonal antibodies (mAbs), according to researchers in Belgium.
Reuters Health Information

Walmart to Stop Sales of E-cigarettes in U.S. Stores - Company Memo

Mon, 23 Sep 2019 20:53:07 +0000

Walmart Inc told staff on Friday it was discontinuing the sale of e-cigarettes and electronic nicotine delivery products at its U.S. stores.
Reuters Health Information

Hot Springs Can Harbor Fatal Parasite

Mon, 23 Sep 2019 20:53:44 +0000

People who swim in hot spring water should do their best to avoid getting water up their nose because it could transmit a deadly parasite, a U.S. case report suggests.
Reuters Health Information

New Kids' Guidelines: Drink Milk, Water, Avoid Plant-Based 'Milk'

Mon, 23 Sep 2019 19:18:44 +0000

New recommendations to guide drink choices for children under 5 emphasize milk and water, discourage juice and most plant-based 'milks.'
Medscape Medical News

EC Clears Cannabidiol for Severe Forms of Epilepsy

Mon, 23 Sep 2019 16:51:34 +0000

Echoing the US Food and Drug Administration's approval last year, the European Commission has approved cannabidiol oral solution for treating seizures associated with two severe forms of epilepsy.
Medscape Medical News

Most Health Data Breaches Expose Sensitive Information

Mon, 23 Sep 2019 17:10:44 +0000

Most breaches compromised sensitive demographic or financial information; exposures of sensitive medical information affected 2.4 million patients during the past decade.
Medscape Medical News

CHMP Supports Interferon-β During Pregnancy, Breastfeeding in MS

Mon, 23 Sep 2019 17:13:56 +0000

The EMA committee advises updating the label of approved interferon-β products to allow use during pregnancy and breastfeeding in women with relapsing multiple sclerosis.
International Approvals

High-Intensity Surveillance Decreases CRC Risk After Adenoma

Mon, 23 Sep 2019 17:45:59 +0000

A modeling study predicts benefit for high-intensity surveillance in these patients; experts emphasize the need for high-quality studies to establish evidence-based surveillance policies.
Medscape Medical News

Experts Take Aim at Vaping Industry's Tobacco-Like Tactics

Mon, 23 Sep 2019 16:06:29 +0000

Scientific research into e-cigarettes is coming under fire after recent reports of vaping-related deaths, and specialists are advocating for antitobacco-type regulations on the industry.
Medscape Medical News

STOP-CRT: Maybe Stop Some HF Meds if CRT Restores Heart Function

Mon, 23 Sep 2019 16:10:05 +0000

It's only one study, but some highly selected patients might improve on cardiac resynchronization therapy such that RAAS inhibitors and beta blockers are no longer indicated, a researcher says.
Medscape Medical News

Plain Water Better Than Hand Sanitizer for Influenza A

Mon, 23 Sep 2019 13:56:13 +0000

Handwashing with plain water was better at killing the influenza A virus than ethanol-based disinfectants, a study found.
Medscape Medical News

Torrent Recalls More Tainted Losartan

Mon, 23 Sep 2019 14:24:47 +0000

It's the fifth recall by Torrent of losartan-containing medicines due to detection of unacceptable levels of a potential carcinogen.
News Alerts

French Weight-loss Pill Scandal Set for Landmark Trial

Mon, 23 Sep 2019 13:06:39 +0000

A landmark French trial to begin next week will seek to settle one of the country's biggest pharmaceutical scandals, probing whether the company behind a weight-loss drug believed to have triggered killer side-effects covered up the risks.
Reuters Health Information

Drug and Medical Suppliers Say Urgently Need Brexit Freight Plans

Mon, 23 Sep 2019 12:51:24 +0000

Makers and suppliers of life-saving drugs and medical devices say they have still not been told by British authorities how their goods will be handled if the UK leaves the European Union without a deal at the end of October.
Reuters Health Information

Big Gains With Denosumab in Osteoporosis a Risk for Later Decline

Mon, 23 Sep 2019 12:44:49 +0000

Post-hoc analysis of DAPS study shows those who had greatest gains in BMD on denosumab were more likely to have losses when taking a bisphosphonate thereafter.
Medscape Medical News

Ученые нашли связь между походкой и риском импотенции

Mon, 23 Sep 2019 18:58:40 +0000

Авторы считают, что эта связь обусловлена слабыми мышцами таза. Эти мышцы задействованы в движении ног и способствуют эрекции, контролируя кровообращение. По мнению японских экспертов, тренировка этих мышц может помочь мужчинам вернуть способность к эрекции.

More Women Internists, but Numbers in Subspecialties Drop

Mon, 23 Sep 2019 11:00:27 +0000

The number of women in cardiology doubled over a quarter century, but the subspecialty continues to have the smallest percentage of women, at 21.3%, a study found.
Medscape Medical News

SUSTAIN-8: Semaglutide vs Canagliflozin After Metformin in T2D

Mon, 23 Sep 2019 11:02:33 +0000

Reduction in HbA1c and weight loss are superior with SC semaglutide compared with canagliflozin, but treatment decisions should also consider patient comorbidities, patient preference, tolerance, and cost.
Medscape Medical News

Скрининг может предупредить до половины случаев рака толстой кишки

Mon, 23 Sep 2019 17:48:36 +0000

Австралийские исследователи доказали эффективность скрининга рака толстой кишки в виде проведения анализа кала на скрытую кровь, который, в случае положительного результата, сопровождается колоноскопией.

Durable Pain Control After Single Radiotherapy to Bone Mets

Mon, 23 Sep 2019 10:51:27 +0000

A single fraction of high-dose radiation provides better and more durable pain control than standard radiotherapy in patients with mostly non-spine bone metastases.
Medscape Medical News

Regret Over Treatment of Prostate Cancer: A Patient's Story

Mon, 23 Sep 2019 06:54:27 +0000

The instability of medical knowledge, especially in oncology, often leads to therapeutic decisions that lead to regret down the road, as this case study highlights.
Medscape Medical News

Антисептик для рук дает ложное чувство защиты от вирусов

Mon, 23 Sep 2019 08:27:51 +0000

Как показало новое японское исследование, быстрое протирание антисептическим спиртосодержащим средством для рук не убивает вирусы, попавшие на руки после чихания или кашля.

Acute Migraine Pain Relief With Oral Rimegepant Yields Lasting Benefits

Sat, 21 Sep 2019 04:13:26 +0000

The acute treatment of migraine with rimegepant can provide lasting reduction in migraine-related disability and improved quality of life, according to new data presented earlier this month at the International Headache Conference (IHC) in Dublin, Ireland.
Reuters Health Information

Unsafe Sex: Argentina Crisis Deflates Condom Sales as Costs Rise

Sat, 21 Sep 2019 05:44:04 +0000

In South America's capital of romance, Argentine lovers are cutting back on one important cost: contraception.
Reuters Health Information

Neurotoxin May Have Caused Diplomats' Illness in Cuba - Study

Sat, 21 Sep 2019 04:58:27 +0000

Fumigation against mosquitoes in Cuba and not "sonic attacks" may have caused some 40 U.S. and Canadian diplomats and family members in Havana to fall ill, according to a new study commissioned by the Canadian government.
Reuters Health Information

Strategies for Slowing Myopia Progression in Kids Differ Widely Between Ophthalmologists

Sat, 21 Sep 2019 04:23:54 +0000

The strategies for slowing myopia progression differ widely among pediatric ophthalmologists around the world and include both effective and ineffective approaches, according to an online survey.
Reuters Health Information

EMA Panel Backs Netarsudil for Elevated Intraocular Pressure

Fri, 20 Sep 2019 18:01:37 +0000

An EMA advisory panel recommended marketing authorization for netarsudil ophthalmic solution 0.02% for the treatment of adults with glaucoma or ocular hypertension.
International Approvals

EU Panel Votes to Expand Dulaglutide Indication Based on REWIND

Fri, 20 Sep 2019 16:58:46 +0000

The panel also recommends approval of Qtrilmet, a fixed-dose combination of metformin hydrochloride/saxagliptin/dapagliflozin for treatment of type 2 diabetes.
International Approvals

EMA Panel Backs Belimumab for Children With Lupus

Fri, 20 Sep 2019 17:08:15 +0000

An EMA panel recommended extending the indication for belimumab to children aged 5 years and older with systemic lupus erythematosus.
International Approvals

EMA Panel Backs Anesthetic Spray for Premature Ejaculation

Fri, 20 Sep 2019 17:29:10 +0000

Senstend, a spray containing lidocaine/prilocaine, can improve ejaculatory control and sexual satisfaction and reduce distress related to ejaculation, the EMA said.
International Approvals

MS Risk Nearly Doubles 15 Years Following Teen Concussion

Fri, 20 Sep 2019 16:24:35 +0000

An association between concussion during adolescence and long-term, elevated risk for multiple sclerosis grew stronger with new evidence from a large study.
Medscape Medical News

FDA OKs Packaging for OTC Loperamide to Help Stem Misuse, Abuse

Fri, 20 Sep 2019 15:15:30 +0000

The changes to Imodium A-D, Imodium Multi-Symptom Relief, and Be Health Loperamide HCl Capsules limit each carton to no more than 48 mg of loperamide and require unit-dose blister packaging.
News Alerts

Adding Patiromer Allows More Spironolactone in Resistant HTN, CKD

Fri, 20 Sep 2019 15:36:10 +0000

With or without heart failure, add-on treatment with the potassium sequestrant 'enabled' more intensive use of the aldosterone blocker otherwise limited by hyperkalemia, according to the AMBER trial.
Medscape Medical News

New Drug Pricing Bill Allows Negotiation With Pharma

Fri, 20 Sep 2019 13:54:29 +0000

Lawmakers are exploring ways to cut drug prices. Major changes in law may be unlikely near-term, but Congress might be able to take a step soon, like capping seniors' Medicare Part D contributions.
Medscape Medical News

FDA Expands Indications for Pifeltro and Delstrigo for HIV

Fri, 20 Sep 2019 14:43:42 +0000

The FDA expanded the indications for the two HIV drugs to include appropriate patients with HIV-1 with virological suppression.
FDA Approvals

FDA OKs 'Game-Changer' Oral GLP-1 Agonist for Type 2 Diabetes

Fri, 20 Sep 2019 13:24:41 +0000

Semaglutide is the first oral glucagon-like peptide-1 receptor agonist. Previously, drugs of this class were available only as injectables. The approval is expected to increase uptake.
FDA Approvals

Trump Executive Order Aims to Speed Flu Vaccine Development

Fri, 20 Sep 2019 13:45:42 +0000

The order creates a new task force charged with coming up with a 5-year plan.
Medscape Medical News

New Option Soon for Some European Patients With Leukemia

Fri, 20 Sep 2019 12:02:46 +0000

Gilteritinib has been recommended for approval for the treatment of adults with relapsed or refractory acute myeloid leukemia (AML) with an FLT3 mutation.
International Approvals

Алкоголь может разрушать печень даже непьющих людей

Fri, 20 Sep 2019 17:19:58 +0000

Китайские ученые считают, что они наткнулись на необычную причину заболевания печени: некоторые бактерии могут производить алкоголь в нашем кишечнике. Результаты они опубликовали в журнале Cell Metabolism.

CAROLINA Published: Reaffirms Sulfonylurea Cardiovascular Safety

Fri, 20 Sep 2019 10:07:34 +0000

The study, presented to a European audience of diabetologists at EASD and simultaneously published in JAMA, reaffirms the CV safety of glimepiride, with calls for FDA warning to be removed.
Medscape Medical News

Физическая активность может замедлить приход симптомов болезни Альгеймера

Fri, 20 Sep 2019 16:16:42 +0000

Новое исследование американских ученых показало, что люди с высоким риском болезни Альцгеймера могут замедлить развитие поражений в головном мозге посредством регулярных аэробных упражнений. Результаты своей работы авторы опубликовали в Journal of Alzheimer’s Disease.

Novel Drug Impresses in Postpartum Depression Phase 3 Trial

Fri, 20 Sep 2019 09:06:07 +0000

Women with postpartum depression may experience significant reductions in symptoms after just 3 days of taking a novel neuroactive steroid, new research suggests.
Medscape Medical News

'Big Jump' in Survival in Advanced Nasopharyngeal Cancer

Fri, 20 Sep 2019 07:28:09 +0000

Gemcitabine/cisplatin induction chemo significantly improved outcomes in locally advanced nasopharyngeal carcinoma in a trial conducted in China.
Medscape Medical News

10 заблуждений, не позволяющих контролировать гипертонию

Fri, 20 Sep 2019 10:16:32 +0000

Народные средства, отказ от физических нагрузок, самостоятельная корректировка лечения: многие пациенты, пытаясь совладать с высоким артериальным давлением, допускают массу ошибок. И этим лишь усугубляют заболевание. Самые распространенные ошибки гипертоников разбирает зав. кардиологическим отделением 17-й городской больницы г. Москвы Наталья Волошина.

[The Lancet Commissions] Malaria eradication within a generation: ambitious, achievable, and necessary

Thu, 19 Sep 2019 23:00:08 +0000

50 years after a noble but flawed attempt to eradicate malaria in the mid-20th century, the global malaria community is once again seriously considering eradication. Momentum towards eradication has been building for decades, and more than half of the world's countries are now malaria free. Since 2000, a surge of global progress has occurred, facilitated by the roll-out of new technologies and the substantial growth in political and financial commitment by countries, regions, and their global partners.

[Clinical Picture] Looking beyond the eyes: visual impairment in posterior cortical atrophy

Thu, 19 Sep 2019 23:00:08 +0000

A 66-year-old, left-handed man was seen in our specialist clinic, complaining of difficulty reading, counting coins, using his mobile phone, and getting dressed. Otherwise, he was managing at home alone and going out independently, albeit with difficulty using stairs and walking on uneven ground. His problems had started 6 years earlier with difficulty reading and fastening his buttons and zips. At that stage, having seen opticians, he was referred to an ophthalmologist and underwent cataract surgery; however, his visual problems continued and got worse.

[Articles] Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial

Thu, 19 Sep 2019 23:00:08 +0000

Fremanezumab was effective and well tolerated in patients with difficult-to-treat migraine who had previously not responded to up to four classes of migraine preventive medications.

[Articles] Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study

Thu, 19 Sep 2019 23:00:07 +0000

Perioperative covert stroke is associated with an increased risk of cognitive decline 1 year after non-cardiac surgery, and perioperative covert stroke occurred in one in 14 patients aged 65 years and older undergoing non-cardiac surgery. Research is needed to establish prevention and management strategies for perioperative covert stroke.

[Articles] Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial

Thu, 19 Sep 2019 23:00:07 +0000

All oral antihypertensives reduced blood pressure to the reference range in most women. As single drugs, nifedipine retard use resulted in a greater frequency of primary outcome attainment than labetalol or methyldopa use. All three oral drugs—methyldopa, nifedipine, and labetalol—are viable initial options for treating severe hypertension in low-resource settings.

[Department of Error] Department of Error

Thu, 19 Sep 2019 23:00:07 +0000

McElearney A, Murphy C, Shevlin M, Stephenson P, Monaghan M, Adamson G. A whole-school child maltreatment prevention programme in primary schools in Northern Ireland: 1 year results of Keeping Safe, a cluster-randomised controlled trial. Lancet 2018; 392: S62—In this Meeting Abstract, the first and third sentence of the Findings section should read as follows: “33 schools were allocated to the intervention (1649 children) and 31 to control (1550 children) groups… After year 1 the intervention group had 31 schools (two schools withdrew in July, 2016, after randomisation, citing changing school leadership as the reason for withdrawal) and the control group had 30 schools (one withdrew in June, 2016, citing sensitive content of questions in outcome measures as reason for withdrawal).” These corrections have been made to the online version as of September 19, 2019.

[Department of Error] Department of Error

Thu, 19 Sep 2019 23:00:07 +0000

Peres MA, Macpherson LMD, Weyant RJ, et al. Oral diseases: a global public health challenge. Lancet 2019; 394: 249–60—In figure 2 of this Series paper, the bracket for employed individuals should only apply to occupation. In the penultimate line of the panel, the amount that PepsiCo has set aside for its Indian operations should read “$5·5 billion”. These corrections have been made to the online version as of September 4, 2019.

[Correspondence] Seeing your older inpatient in better times

Thu, 19 Sep 2019 23:00:07 +0000

Hospitalised patients swap their clothes for a hospital gown and their independence for compliance with hospital routines and staff's instructions. Much of their identity and individuality can be effaced under these circumstances, especially when they are regarded as one of many clinical problems to be dealt with as efficiently as possible.1 This problem is considerably worse for the increasing population of older geriatric patients whose common multimorbidity, waning faculties, cognitive decline, dependence, and poor appearance all act to distance the health-care team from the patient as a person.

[Correspondence] Air disinfection in measles transmission hotspots

Thu, 19 Sep 2019 23:00:07 +0000

Measles is the most contagious airborne infection. The long-term solution to the increasingly common outbreaks of measles is to re-establish herd immunity through vaccination. Although immunisation is the optimal approach to preventing measles, upper-room germicidal ultraviolet (GUV) air disinfection, a readily available environmental intervention with proven efficacy, should be used in selected paediatric waiting rooms, school classrooms, cafeterias, and other group settings that are key sites of transmission.

[Correspondence] Victorian systems will not solve modern prison health problems

Thu, 19 Sep 2019 23:00:07 +0000

We commend Kim Price and Barry Godfrey1 for their thoughtful work on prison health, looking to the period since the 19th century and showing the remnants of the Victorian past in today's prison health in the UK. Particularly, we support their approach towards mental health care for prisoners. However, we would like to add two essential elements that are important for preventing infection in the prison population, both of which are unfortunately missing in prisons in the UK and many other parts of the world.

[Correspondence] Foundation for a Smoke-Free World: independent and making progress

Thu, 19 Sep 2019 23:00:07 +0000

Tess Legg and colleagues1 make unsubstantiated claims about the Foundation for a Smoke-Free World's progress and independence. They cite disclosures made in our 2018 tax return2 to suggest we are struggling.1 However, the authors’ assessment disregards the substantial progress outlined in our annual report,3 which was released alongside the tax return. The Foundation is where it was projected2 to be when we launched in 2017.4

[Correspondence] Environmental consequences of tobacco production and consumption

Thu, 19 Sep 2019 23:00:07 +0000

Vin Gupta and colleagues1 draw attention to the synergies between air pollution and tobacco exposure and suggest that it might be possible to leverage growing concern about the health effect of air quality to improve the global implementation of tobacco control measures. This is a welcome suggestion, but governments and other agencies should be encouraged to think even more widely when considering the environmental effects of tobacco production and consumption, as outlined in two reports.2,3

[Correspondence] Analysis of the RIMDAMAL trial – Authors' reply

Thu, 19 Sep 2019 23:00:07 +0000

We thank John Bradley and colleagues1 for their inquiry into our results and conclusions. Our study design of a few clusters (a total of eight were randomly assigned to the control or intervention group) was necessitated by the RIMDAMAL trial being a modestly funded pilot trial on ivermectin efficacy and safety.2 Furthermore, because we hypothesised that the ivermectin treatment would most affect clinical malaria incidence in this population living in a hyperendemic area, frequent measures of malaria incidence by study nurses were required.

[Correspondence] Analysis of the RIMDAMAL trial

Thu, 19 Sep 2019 23:00:07 +0000

The results of the RIMDAMAL trial in Burkina Faso, reported by Brian Foy and colleagues,1 show that repeated mass treatment with ivermectin can reduce the incidence of malaria in children aged 5 years or younger, with no serious adverse effects.

[Correspondence] Analysis of the RIMDAMAL trial

Thu, 19 Sep 2019 23:00:07 +0000

We read with interest the article by Foy and colleagues1 on ivermectin for malaria control and are pleased such research is being conducted. However, we have serious misgivings about their statistical methods and conclusions. It is unlikely that a trial with only four clusters per arm could reach such firm conclusions. Individual participants in cluster-randomised trials do not constitute independent observations. Analysis must account for the clustered structure of the data and we do not believe this was done.

[Correspondence] Women's rights will drive universal health coverage

Thu, 19 Sep 2019 23:00:07 +0000

We support Simon Wright and Refiloe Mabjeane,1 who wrote on behalf of the Civil Society Engagement Mechanism for UHC2030, calling for a “radically different approach” to the UN high-level meeting on universal health coverage (UHC) on Sept 23, 2019. However, a radically different approach means prioritising gender equality and girls and women's health and rights in UHC, and this includes the health workforce.

[Perspectives] Dementia: towards a new republic of hope

Thu, 19 Sep 2019 23:00:07 +0000

“You have dementia.” Dreaded words that physicians hate to deliver and individuals wish never to personally receive. Dementia is typically regarded as a death sentence, a disease without a cure, a long slow deterioration, increasing dependency, and a loss of hope. But framing dementia in this way only adds to the fear and stigma surrounding this disease. One of us (BL) has spent over 30 years of clinical practice ruling out all other possibilities before telling a patient they have dementia. The other one of us (DW), partnered her mother, Alice, through a long dementia journey, during which Alice would often ask “Where am I? Why am I here?” Together, we trace some of the social origins of dementia's stigma and offer a way to restore hope that is independent of whether a cure is on the horizon or not.

[Perspectives] Physicians, oaths, and vampires

Thu, 19 Sep 2019 23:00:07 +0000

In a provocative study titled “Does the Hippocratic Oath promote burnout?”, more than 2600 physicians were asked whether putting patient needs before their own, as required by their oath, heightened the danger of burnout. The results were mixed: roughly half believed that it did not and half were unsure or thought that it did. These findings confront one of the most cherished tenets of medicine, that doctors must put their pledge to their patients above everything else: their time, compensation, families, and even their own health and wellbeing.

[Perspectives] Food as spectacle

Thu, 19 Sep 2019 23:00:07 +0000

There were long queues for the Christian Dior: Designer of Dreams when I went to London's Victoria & Albert Museum (V&A), but none for the FOOD: Bigger than the Plate exhibition. I went to the latter out of choice, I should declare. Both are large exhibitions but the contrast and similarities are intriguing: glamour versus the mundane; the elision of reality and fantasy; the application of not dissimilar marketing techniques; the effects of technology; the hidden labour force alongside celebrities; and more.

[World Report] Blood transfusion in Kenya faces an uncertain future

Thu, 19 Sep 2019 23:00:06 +0000

By the end of September, 2019, PEPFAR will stop supporting blood transfusion in Kenya, with no clear plan for the future. Paul Adepoju reports.

[Comment] Offline: Transcending the guilt of global health

Thu, 19 Sep 2019 23:00:06 +0000

Any western medical institution more than a century old and which claims to stand for peace and justice has to confront a painful truth—that its success was built on the savage legacy of colonialism. Perhaps we deal with uncomfortable pasts by burying them, excusing them, or atoning for them. The Lancet, for example, is a colonial-era institution. Its editors today must be exquisitely sensitive to the ethics of memory. How easy it is for us to pronounce on what others should do from our position of advantage.

[Comment] Five reasons for optimism on World Patient Safety Day

Thu, 19 Sep 2019 23:00:06 +0000

On Sept 17, 2019, WHO and its member countries will mark the first World Patient Safety Day. Patient safety has finally been recognised as a top global health priority, but much more work needs to be done to eliminate patient harm. Adverse events due to unsafe health care are among the leading causes of death and disability worldwide1 and exacerbate health inequalities since people in low-income and middle-income countries (LMICs) are more likely to suffer patient harm than those in high-income countries.

[Comment] Public health in the Eastern Mediterranean Region: profound challenges, huge opportunities

Thu, 19 Sep 2019 23:00:06 +0000

When I became WHO's Regional Director for the Eastern Mediterranean in May, 2018, I felt honoured but slightly anxious. The WHO Regional Office for the Eastern Mediterranean serves 21 member states and Palestine (West Bank and Gaza Strip) with a population of more than 600 million. The region faces many challenges, including health and humanitarian emergencies on an unprecedented scale. However, I believe I am well placed to help tackle these challenges. My background as a family physician and hospital director has shown me the value of effective organisation, collaboration, and leadership with the focus always on helping each patient and their family.

[Comment] The malaria eradication challenge

Thu, 19 Sep 2019 23:00:06 +0000

Eradicating malaria has been one of the ultimate public health goals for a century. It is also proving to be one of the greatest challenges. That said, malaria has been eliminated progressively in many parts of the world. By the 1950s, malaria had been eliminated from much of the temperate zone, and from that point until now, WHO has certified 38 countries and overseas territories as malaria free.1 The global malaria death rate declined by more than 60% between 2000 and 2015.2

[Comment] An Africa free of malaria

Thu, 19 Sep 2019 23:00:06 +0000

Despite international efforts to control and eliminate malaria for the past century, the disease continues to be a public health threat, particularly in sub-Saharan Africa. In 2017, there were an estimated 200 million malaria cases and 403 000 deaths across the region, of which 61% were children younger than 5 years.1 The WHO Director-General's 1954 annual report,2 considered at the Eighth World Health Assembly, adopted malaria eradication for all endemic countries except mainland sub-Saharan Africa and Madagascar (resolution WHA8.30 [1955] and statement of Dr Williams).

[Comment] Is targeting CGRP the right pathway to prevent migraine?

Thu, 19 Sep 2019 23:00:06 +0000

For patients with migraine, preventive treatments are key. However, available drugs, including β blockers, antidepressants, antiepileptics, and botulinum toxin were licensed for other disorders and their efficacy in preventing migraine was shown more often than not through serendipity. The scarcity of novel therapeutic approaches reflects the partial and sometimes nebulous knowledge of the neurobiology of migraine. Although drug repurposing has become a widespread migraine prevention strategy, targets and mechanisms of action are not clearly defined.

[Comment] Uncovering covert stroke in surgical patients

Thu, 19 Sep 2019 23:00:06 +0000

Stroke can be a devastating complication of surgery, with few effective strategies for detection or prevention. Overt stroke (ie, stroke with clinically apparent manifestations) occurs in approximately 0·1–1·0% of patients undergoing non-cardiac surgery and is associated with a higher mortality than that in patients who did not have a stroke.1 In the non-surgical setting, covert stroke is more common than overt stroke and is associated with cognitive decline.2 However, the incidence and sequelae of covert stroke in the perioperative setting remain unknown.

[Comment] Oral regimen management of acute hypertension in pregnancy

Thu, 19 Sep 2019 23:00:06 +0000

Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality worldwide, and they are directly responsible for approximately 14% of maternal deaths.1 Often, women present in hypertensive urgency, requiring rapid pharmacological intervention to prevent severe complications.2 The largest burden of disease is found in low-income and middle-income countries (LMICs),1 where poor access to refrigeration, trained health-care professionals, fetal monitoring, and drug options create substantial challenges to the administration of rapid-acting intravenous medications.

[Editorial] The mental health imperative of children in conflict

Thu, 19 Sep 2019 23:00:06 +0000

On Sept 10, ahead of the UN General Assembly and a mental health in emergencies summit in the Netherlands (Oct 7–8), Save the Children released Road to Recovery: Responding to children's mental health in conflict. The report states that 142 million children are living in high-intensity conflict zones, with many more millions forced to abscond as refugees. More than 24 million children exposed to conflict today are likely to encounter mild to moderate mental health problems yet, as Save the Children rightly contends, the global response to mental health support continues to be regrettably inadequate.

[Editorial] Childhood cancer: unequal progress

Thu, 19 Sep 2019 23:00:06 +0000

September is Childhood Cancer Awareness Month. Each year more than 300 000 children younger than 19 years are diagnosed with cancer worldwide. Numbers of deaths have been steadily increasing mostly because of new cases in low-income and middle-income countries (LMICs).

[Editorial] iHuman: a futuristic vision for the human experience

Thu, 19 Sep 2019 23:00:06 +0000

On Sept 10, 2019, the Royal Society published a report, iHuman: blurring lines between mind and machine, which presents a vision for how emerging neural interface technologies (NITs) could transform the future of medicine by the use of invasive and non-invasive neural devices that inter-relate with the central and peripheral nervous system. The report recognises potential ethical, sociopolitical, and commercial concerns that might be introduced.

Court Overturns CMS' Site-Neutral Pay Policy; Doc Groups Upset

Thu, 19 Sep 2019 17:44:10 +0000

There's no word yet on whether CMS will appeal, but the hospital sector is rejoicing; employed doctors can continue to bill more than independents for E&M visits.
Medscape Medical News

Novel TAVR Approach Dramatically Cuts Need for Pacemaker

Thu, 19 Sep 2019 16:10:07 +0000

TAVR carries risk of postprocedure pacemaker implantation. A new technique using the patient's individual anatomy to determine device location may decrease this complication, a new study suggests.
Medscape Medical News

Can Electronic Gaming Trigger Dangerous Arrhythmias?

Thu, 19 Sep 2019 16:37:05 +0000

Ventricular arrhythmias are typically exacerbated by physical exercise, but a new case series suggests even sedentary activities may increase the risk in children with certain conditions.
Medscape Medical News

Harm Reduction Programs Lower Rate of Hep C Reinfection

Thu, 19 Sep 2019 15:13:50 +0000

Hepatitis C reinfection rates are high for injection-drug users. Although rates at centers with harm-reduction programs are lower, they might not be treating high-risk populations, one expert warned.
Medscape Medical News

FDA Launches Criminal Probe as Vaping-Related Illnesses Top 500

Thu, 19 Sep 2019 14:03:44 +0000

There are now 530 confirmed and probable cases of lung injury associated with e-cigarettes and vaping products in the United States, as federal and state authorities continue searching for the cause. The FDA has launched a criminal investigation.
News Alerts

Valley Fever on the Rise and Spreading, CDC Says

Thu, 19 Sep 2019 14:37:34 +0000

The number of valley fever cases has grown almost 75% since 2014, and the Coccidioides fungus has been reported as far north as central Washington, according to the CDC.
Medscape Medical News

ENTRUST-AF PCI Supports Safety of Dual Therapy With Edoxaban

Thu, 19 Sep 2019 14:40:23 +0000

ENTRUST AF-PCI completes the trials of NOACs in patients with AF who undergo PCI, showing dual therapy with edoxaban was noninferior to vitamin K-antagonist–based triple therapy.
Medscape Medical News

EAN Guidelines Endorse Early Palliative Care Dialogue in MS

Thu, 19 Sep 2019 13:22:48 +0000

Both specialists and general practitioners caring for people with severe MS and their families should discuss palliative care options in advance, new guidelines emphasize.
Medscape Medical News

Hypertension Linked to Cognitive Decline, but Treatment Helps

Thu, 19 Sep 2019 13:48:33 +0000

In a large Chinese population study, the treatment of hypertension was linked to a slower progression of cognitive decline.
Medscape Medical News

Regular Exercise May Slow Progression to Alzheimer's

Thu, 19 Sep 2019 12:18:32 +0000

Aerobic exercise slows hippocampal atrophy and improves memory in some older patients at high risk for Alzheimer disease, but stretching also benefits the brain.
Medscape Medical News

AAN Calls for Annual Cognitive Testing; USPSTF Begs to Differ

Thu, 19 Sep 2019 12:30:45 +0000

A new AAN guideline calling for annual cognitive testing in all adults age 65 or older runs contrary to a recommendation by the USPSTF that claims there is not enough evidence to warrant such a move.
Medscape Medical News

Cleaners and Factory Workers Have High Rates of Type 2 Diabetes

Thu, 19 Sep 2019 12:31:24 +0000

A Swedish study identifies certain menial jobs that are associated with a higher risk of type 2 diabetes and suggests that workplace wellness programs targeted at certain occupations could improve health.
Medscape Medical News

DAPA-HF Published: 'Stunning Consistent Benefit With Dapagliflozin'

Thu, 19 Sep 2019 11:15:50 +0000

Publication of trial reinforces "remarkably consistent" benefits of the SGLT2 inhibitor dapagliflozin in patients with heart failure, with or without diabetes, "bolsters confidence in the conclusions."
Medscape Medical News

В Россию возвращаются медвытрезвители

Thu, 19 Sep 2019 17:23:57 +0000

Правительство поддержало законопроект о возрождении медвытрезвителей. При этом, ведомство посчитало излишним вопрос о необходимости информированного добровольного согласия гражданина на оказание такой помощи. Ранее инициативу поддержал Минздрав, в чьи учреждения полиция ежегодно доставляет более полумиллиона лиц в состоянии алкогольного опьянения.

India Bans E-Cigarettes as Global Backlash at Vaping Gathers Pace

Thu, 19 Sep 2019 10:22:09 +0000

India banned the sale of electronic cigarettes on Wednesday and warned of an "epidemic" among young people, in the latest and potentially biggest move against vaping globally over growing health concerns.
Reuters Health Information

New Data on Natalizumab During Pregnancy in MS

Thu, 19 Sep 2019 10:23:15 +0000

Women with multiple sclerosis who continued to receive the drug during pregnancy had a much lower risk of relapses, according to a new Italian observational study.
Medscape Medical News

Alzheimer's Drug Linked to Life-Threatening Muscle Condition

Thu, 19 Sep 2019 10:32:34 +0000

Results of a large population-based cohort study support regulatory agency warnings about the risk for donepezil-induced rhabdomyolysis, a rare but potentially life-threatening condition.
Medscape Medical News

Novel Agent Imeglimin Improves Glucose Control in Type 2 Diabetes

Thu, 19 Sep 2019 09:39:06 +0000

The first-in-class "glimin" works at the mitochondrial level, targeting multiple defects in type 2 diabetes. Initial Phase 3 trials are ongoing in Japan, with studies planned for the US and Europe.
Medscape Medical News

Гормональные контрацептивы связали с риском развития диабета

Thu, 19 Sep 2019 15:45:11 +0000

Новое исследование показывает, что использование противозачаточных таблеток и более продолжительные менструальные циклы связаны с повышенным риском развития диабета 2 типа, в то время как более позднее половое созревание и поздняя менопауза связаны с более низким

With a Backup to the Backup, Insulin Makers Say They're Primed for Brexit

Thu, 19 Sep 2019 08:40:53 +0000

For two men trained as scientists, the bosses of Britain's major insulin providers have had to become experts in ferry schedules, trucking laws and warehouse capacity as they seek to guarantee the supply of life-saving drugs through a chaotic Brexit.
Reuters Health Information

AI Could Improve Healthcare for All -- Unless it Doesn't

Thu, 19 Sep 2019 08:20:00 +0000

AI-driven medical tools could democratize health care, but some worry they could also worsen inequalities.
Undark

Former Med Student Headed to Prison for Murder-for-Hire Plot

Thu, 19 Sep 2019 07:01:08 +0000

Steven Arce tried to hire a hitman to kill a University of Iowa associate dean after being dismissed from the medical school.
Medscape Medical News

AMA Awards Multiple Innovation Grants to Medical Schools

Thu, 19 Sep 2019 07:41:35 +0000

The emphasis is on health systems science, which was scarcely taught in medical schools 6 years ago.
Medscape Medical News

ЭКО по ОМС, электронные медкарты и детская реабилитация

Thu, 19 Sep 2019 12:37:49 +0000

Об этом эксперты Федерального фонда ОМС рассказали в ходе прямой линии, прошедшей в рамках рубрики «Минздрав на связи» в эфире социальной сети «Одноклассники» и на сайте Фонда. На вопросы россиян отвечали зампред ФОМС Светлана Кравчук и председатель Совета по медицинскому страхованию Всероссийского союза страховщиков Андрей Рыжаков.

Most Parents Say Their Kids Have Ridden With a Risky Teen Driver

Thu, 19 Sep 2019 02:58:40 +0000

A majority of parents worry that their children have been in unsafe situations as passengers traveling with a teen driver, a new survey finds.
Reuters Health Information

Caregivers of Seriously Ill Spouses Find Life Improves More When the Partner Dies

Thu, 19 Sep 2019 03:07:30 +0000

For caregivers tending to a seriously ill spouse, quality of life may improve to a greater extent if the partner dies than if the partner recovers, a German study suggests.
Reuters Health Information

Incidence of Type 2 Diabetes Up in Younger People and Risks Greater

Thu, 19 Sep 2019 02:30:37 +0000

Since the year 2000 the proportion of younger people with type 2 diabetes has risen and these people have higher cardiovascular risk factors than older diabetics, including obesity and high HbA1c and LDL cholesterol levels.
Medscape News UK

Ученые уточнили, каким пациентам аспирин нужен для профилактики

Thu, 19 Sep 2019 08:37:40 +0000

Новозеландские ученые выяснили, что преимущества приема аспирина могут перевешивать риски для многих пациентов без диагностированных сердечно-сосудистых заболеваний, только необходим персонализированный анализ соотношения пользы-вреда.

Recommended TSH Norm for Patients on Thyroxine Shows No Ill Effect

Thu, 19 Sep 2019 01:34:36 +0000

Recommended "normal" thyroid-stimulating hormone (TSH) concentrations for hypothyroid patients receiving thyroxine are not associated with increased risk of cardiovascular disease, fractures, or all-cause mortality, according to new findings.
Reuters Health Information

Point-of-Care Testing Useful for Newborn Sickle Cell Screening

Thu, 19 Sep 2019 01:40:48 +0000

Point-of-care testing is useful for newborn screening for sickle cell disease (SCD) in low-income settings, according to results from an observational study.
Reuters Health Information

Data in EHRs Don't Match Physicians' Exam, Study Suggests

Wed, 18 Sep 2019 20:07:29 +0000

Only about 40% of review of systems and 50% of physical examination systems were corroborated by direct observation in a small study of emergency visits.
Medscape Medical News

Generic Zantac Distribution Halted Worldwide

Wed, 18 Sep 2019 18:37:03 +0000

Zantac's manufacturer has halted distribution of the drug after findings that the medication may have become tainted with a cancer-causing agent.
News Alerts

US Study Points Way to Polypill for CVD Prevention

Wed, 18 Sep 2019 17:04:37 +0000

Although the polypill could improve adherence and reduce health inequities, little progress has been made in its implementation worldwide, particularly in the United States.
Medscape Medical News

US Physicians Highest Paid Globally, but Spend Most for Training

Wed, 18 Sep 2019 17:41:20 +0000

In some countries, public medical education is free or costs little. Gender gaps were evident in pay across all seven countries compared.
Medscape Medical News

Few Physicians Screen for Social Determinants of Health

Wed, 18 Sep 2019 15:58:19 +0000

Most US hospitals and physician practices do not screen for five social determinants of health: food insecurity, housing instability, utility needs, transportation needs, and interpersonal violence.
Medscape Medical News

Parental Jail Time May Mean a Life Sentence for Kids

Wed, 18 Sep 2019 13:32:51 +0000

Parental incarceration is associated with a significantly increased risk of mental illness in offspring that can start in childhood and extend into adulthood, new research shows.
Medscape Medical News

Blood Lipid Changes at Age 8 in Kids Genetically Prone to Diabetes

Wed, 18 Sep 2019 11:16:43 +0000

Children who have a high genetic risk score for adult type 2 diabetes also appear to have lower levels of HDL, or 'good' cholesterol, as early as age 8.
Medscape Medical News

Стартовала международная акция «VII Ежегодная неделя ранней диагностики рака головы и шеи»

Wed, 18 Sep 2019 17:03:44 +0000

С 16 сентября акция проходит в России, странах Европы, Бразилии и Южной Корее. По официальным данным, число жертв этого коварного недуга растет. И главное оружие против него – выявление заболевания на ранних стадиях. В дни проведения акции любой желающий может бесплатно пройти осмотр в амбулаторном кабинете в Университетской клинической больнице № 1 Сеченовского университета.

CGM, Not Insulin Pump, 'Is What Makes Difference' in Type 1 Diabetes

Wed, 18 Sep 2019 09:59:17 +0000

"It is not so important how insulin is delivered, but more important is how patients with type 1 diabetes monitor their glucose," says the author of the longest running study comparing different approaches.
Medscape Medical News

Reimagining STI Clinics for a New Generation

Wed, 18 Sep 2019 09:59:47 +0000

Clinics that are designed to be stylish, easy to access, and efficient are changing the way cities tackle STI testing and treatment.
Medscape Medical News

Cosmetic Outcomes Equal After Partial vs Whole Breast Radiation

Wed, 18 Sep 2019 10:10:03 +0000

Partial breast irradiation now proves to be equal to whole breast irradiation not only in oncologic outcomes but also in cosmetic outcomes as assessed by patients themselves.
Medscape Medical News

For the Uniformed Public Health Service, Existential Questions Abound

Wed, 18 Sep 2019 10:32:35 +0000

The Commissioned Corps of the US Public Health Service is steeped in history, and nagged by charges of bloat, inertia, and redundancy. Is that fair?
Undark

Частицы из загрязненного воздуха способны проникать через плаценту и воздействовать на плод

Wed, 18 Sep 2019 16:58:51 +0000

В ходе нового исследования бельгийские ученые из Университета Хасселта обнаружили частицы черного углерода (сажи) из загрязненного воздуха на плодовой стороне плаценты Это указывает на то, что неродившиеся дети непосредственно подвергаются воздействию этого вещества, которое является продуктом сгорания различных видов топлива.

VERIFY: Metformin + DPP-4 Inhibitor as Dual Therapy for Diabetes?

Wed, 18 Sep 2019 08:07:47 +0000

VERIFY suggests that initial combination therapy for type 2 diabetes with metformin plus vildagliptin is well tolerated and effective; risk for treatment failure was 50% lower than in those on monotherapy.
Medscape Medical News

What Do You Think About Hospital Data Partnerships With Big Tech?

Wed, 18 Sep 2019 08:37:31 +0000

Under a new 10-year partnership, the Mayo Clinic will store patient data with Google Cloud and use the tech giant's technology to develop new healthcare tools.
Medscape Reader Polls

Удаление волос на лобке не связано с венерическими болезнями

Wed, 18 Sep 2019 09:07:55 +0000

Результаты исследования, проведенного американскими учеными, опровергли распространенный миф о том, что полное удаление лобковых волос повышает риск инфекций, передающихся половым путем.

Mint, Menthol E-Cigarette Liquids High in Cancer-Causing Compound - Study

Tue, 17 Sep 2019 23:24:10 +0000

A cancer-causing compound banned by U.S. regulators last year as a food additive has been found at potentially dangerous levels in mint and menthol flavored e-cigarette liquids and smokeless tobacco products, researchers said on Monday.
Reuters Health Information

It Really Is Hard to Sleep in the ER

Tue, 17 Sep 2019 23:29:12 +0000

Patients who spend the night in the emergency room may get much less rest than patients who sleep in beds in hospital rooms, a small study suggests.
Reuters Health Information

U.S. CDC Activates Emergency Operations Center for Vaping-Related Illnesses

Tue, 17 Sep 2019 22:29:55 +0000

The U.S. Centers for Disease Control and Prevention (CDC) said on Monday it has activated its emergency operations center to coordinate the investigation into hundreds of cases of severe lung illnesses linked to e-cigarette use.
Reuters Health Information

Weill Cornell Jumps on Free Medical School Tuition Bandwagon

Tue, 17 Sep 2019 17:18:28 +0000

Weill Cornell will provide debt-free education to all medical students who need financial aid by replacing student loans with scholarships covering tuition, housing, and other living expenses.
Medscape Medical News

A New Drug for HF? DEFINE-HF Bolsters Dapagliflozin Cardio Cred

Tue, 17 Sep 2019 17:39:37 +0000

On the heels of the DAPA-HF outcomes trial, DEFINE-HF shows adding the SGLT-2 inhibitor to standard meds improved other endpoints heart failure patients care about, whether or not they had diabetes.
Medscape Medical News

Older Patients Don't See Diabetes Recommendations Same Way Doctors Do

Tue, 17 Sep 2019 16:05:57 +0000

Doctors' advice for starting or stopping diabetes medicines often doesn't resonate with older patients, a new study suggests.
Reuters Health Information

Shock and Awe: ARNI for Acute HF May Be Safely Started in ICU

Tue, 17 Sep 2019 16:24:44 +0000

Some patients in cardiogenic shock may transition from IV vasoactive agents to sacubitril/valsartan without going hypotensive, suggests a small case series; PA-pressure guidance was crucial.
Medscape Medical News

Small Prolonged Reductions in LDL, BP Substantially Reduce CV Risk

Tue, 17 Sep 2019 16:43:54 +0000

A new Mendelian randomization study shows the large benefits that could be achieved from small reductions in cholesterol and blood pressure if maintained over a lifetime.
Medscape Medical News

US, Canada, Australia Approve Endometrial Cancer Combo

Tue, 17 Sep 2019 15:27:12 +0000

Regulatory agencies in three countries, including the United States, all approved lenvatinib in combination with pembrolizumab for the treatment of patients with advanced endometrial carcinoma.
FDA Approvals

USPSTF Finds Evidence Insufficient for Routine MCI Screening

Tue, 17 Sep 2019 14:21:55 +0000

Should asymptomatic older adults be screened for incipient dementia? No, according to this draft recommendation released by the USPSTF.
Medscape Medical News

TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis

Tue, 17 Sep 2019 14:31:21 +0000

The results suggest TAVR should be the preferred option in low-risk patients, but the author and observers caution against widespread application beyond the inclusion criteria of the individual trials.
Medscape Medical News

Left-Handed Genetic Variants Linked to Brain Connectivity, Neuropsychiatric Diseases

Tue, 17 Sep 2019 13:36:35 +0000

Genetic variants associated with left-handedness influence brain connectivity and might be related to the pathogenesis of such neuropsychiatric diseases as Parkinson's disease and schizophrenia, researchers from U.K. report.
Reuters Health Information

Underserved Communities Receive Hep C Treatment in Jail

Tue, 17 Sep 2019 13:23:12 +0000

The testing and treatment of inmates for hepatitis C can be effective, but system efficiencies, perceptions, and limits on care after release can present obstacles.
Medscape Medical News

Radiation May Boost Immunotherapy in Metastatic Lung Cancer

Tue, 17 Sep 2019 13:41:54 +0000

Adding radiation after progression on immunotherapy increased progression-free survival in some patients.
Medscape Medical News

Новости из жизни инфекций

Tue, 17 Sep 2019 19:00:24 +0000

Исследования распространенности различных инфекций в России и мире, а также сравнительный анализ современных методов их выявления стали основными темами III Форума «Молекулярная диагностика», прошедшего в середине сентябре в Москве в рамках V Российского конгресса лабораторной медицины.

В Германии расследуют причины рождения детей с деформациями кистей рук

Tue, 17 Sep 2019 19:20:56 +0000

В больнице Святой Марии города Гельзенкирхен земли Северный Рейн-Вестфалия сообщили, что в период с июня по начало сентября этого года трое детей родились с «односторонними деформациями кисти»: «У двоих из затронутых детей деформирована левая рука – у них нормальное предплечье, но ладони и пальцы неразвиты. У третьего ребенка затронута правая рука – и здесь рука и пальцы не был

Long-Term Pentosan Polysulfate Sodium Use Associated With Vision-Threatening Maculopathy

Tue, 17 Sep 2019 11:56:15 +0000

Long-term use of the interstitial cystitis drug pentosan polysulfate sodium (PPS) is associated with a vision-threatening pigmentary maculopathy, a case series suggests.
Reuters Health Information

Положение тела во время сна не влияет на исход беременности

Tue, 17 Sep 2019 09:54:39 +0000

Несмотря на стандартные врачебные рекомендации для беременных спать на левом боку, американские исследователи выяснили, что положение тела во время сна не оказывает влияния на повышение вероятности негативных исходов.

Combo Therapy No Better Than Surgery Alone for Incontinence

Tue, 17 Sep 2019 11:00:00 +0000

Adding combination therapy to midurethral sling surgery in women with mixed urinary incontinence was not statistically significantly better compared with surgery alone, a study found.
Medscape Medical News

Virtual Reality Helps Kids Getting X-Rays

Tue, 17 Sep 2019 10:03:21 +0000

A virtual reality program with cartoon characters may reduce children's fear before imaging procedures, a South Korean study suggests.
Reuters Health Information

Vegan Diet Alters Microbiome and Insulin Sensitivity, Drops Weight

Tue, 17 Sep 2019 10:35:58 +0000

Adopting a vegan diet seems to alter the gut microbiome and improve insulin sensitivity with associated weight loss, compared to eating conventionally even with no direction to restrict calorie intake.
Medscape Medical News

Obesity Poses Much Bigger Risk for Diabetes Than Bad Genes

Tue, 17 Sep 2019 09:36:59 +0000

The study highlights the dominance of obesity as a risk factor for type 2 diabetes and reinforces the "importance of weight management in diabetes prevention...in all genetic risk groups," say researchers.
Medscape Medical News

Physicians Still Weak on HPV Vaccine Delivery, Despite Benefits

Mon, 16 Sep 2019 18:12:54 +0000

Adopting a more presumptive approach with parents may increase low vaccination uptake and completion, especially in younger adolescents.
Medscape Medical News

Fewer Patients Require 'Surgical Bailout' After TAVR

Mon, 16 Sep 2019 15:51:47 +0000

TAVR carries a risk for complications that may necessitate conversion to open heart surgery, which carries high risk for mortality, but rates of 'surgical bailout' have decreased over time.
Medscape Medical News

Ofatumumab Impresses in MS; Competition for Ocrelizumab Soon?

Mon, 16 Sep 2019 16:32:15 +0000

A new B cell-depleting therapy, given as a monthly subcutaneous injection, has shown impressive results in two phase 3 studies in relapse-remitting multiple sclerosis.
Medscape Medical News

Marijuana Use Linked to Improved Acute-HF Hospital Survival

Mon, 16 Sep 2019 13:54:04 +0000

Chronic cannabis use seemed to protect against in-hospital death and shorten length of stay in the observational study with propensity matching — but not in all types of heart failure.
Medscape Medical News

Optimized AED Placement May Improve Cardiac Arrest Outcomes

Mon, 16 Sep 2019 14:23:05 +0000

A computer simulation shows that automated external defibrillator (AED) deployment can be optimized to increase accessibility and possibly survival after cardiac arrest.
Medscape Medical News

VT Reduced With Single Radiation Treatment

Mon, 16 Sep 2019 14:43:52 +0000

A noninvasive mapping and intervention approach for patients with refractory ventricular tachycardia opens a new frontier for those with no other treatment options and for whom SBRT represents the only final solution.
Medscape Medical News

Indigenous Approach to Healing Key for Hepatitis C Patients

Mon, 16 Sep 2019 14:48:24 +0000

The treatment of indigenous people requires that healthcare providers consider a holistic approach to wellness, and an addiction clinic in Montreal has proven that the approach works.
Medscape Medical News

Неосторожное иглоукалывание привело к проколу легкого

Mon, 16 Sep 2019 18:59:48 +0000

В Новой Зеландии иглотерапевт переусердствовал, работая с пациенткой: слишком глубокое введение игл вызвало коллапс легкого. Женщина утверждает, что не была предупреждена о возможных проблемах.

More Evidence Ties Social Media to Mental Health Problems

Mon, 16 Sep 2019 10:59:51 +0000

New study found that the more time teens spend on social media, the higher their risk for depression and other internalizing problems.
Medscape Medical News

Historic High as Obesity Exceeds 35% in Nine US States

Mon, 16 Sep 2019 09:52:14 +0000

"These latest data shout that our national obesity crisis is getting worse," says the CEO of a nonprofit organization that publishes an annual report on the state of obesity in America.
Medscape Medical News

Массовая вакцинация против ВПЧ защищает непривитых мужчин от рака глотки

Mon, 16 Sep 2019 14:10:06 +0000

Распространенность папилломовирусной инфекции ротовой полости и глотки среди мужчин, не привитых от нее, в США снизилась на 37%. Ученые считают, что это произошло благодаря появлению популяционного иммунитета вследствие массово проводимой вакцинации против вируса папилломы человека (ВПЧ).

FDA Panel Backs First-in-Class Medication for Peanut Allergy

Mon, 16 Sep 2019 07:34:12 +0000

An FDA advisory panel recommended peanut allergen powder (Palforzia, Aimmune Therapeutics) for children aged 4 years through 17 years who are allergic to peanuts.
Medscape Medical News

Эректильная дисфункция может быть предвестником инсульта и инфаркта

Mon, 16 Sep 2019 08:36:24 +0000

Мужчины, страдающие эректильной дисфункцией (ЭД), впоследствии могут столкнуться с еще большей проблемой, так как она может говорить о повышенном риске инсульта или инфаркта. К такому выводу пришли американские ученые, изучив данные более 150000 мужчин.

Alcohol Taxes Not Close to Covering Cost of Drinking Harms in the U.S.

Mon, 16 Sep 2019 00:09:03 +0000

The sum total of taxes on alcohol doesn't come close to paying the bills associated with excessive alcohol consumption in the U.S., researchers say.
Reuters Health Information

Suicide Rates Highest and Rising Fastest in U.S. Rural Communities

Mon, 16 Sep 2019 00:03:14 +0000

Suicide rates are rising across the U.S., especially in rural communities and places with high poverty and a proliferation of gun shops, a new analysis suggests.
Reuters Health Information

US FDA Has Resources Available for Gastroenterologists

Sun, 15 Sep 2019 23:49:42 +0000

Resources from the FDA are available online and gastroenterologists should take advantage of them, according to correspondence in the American Journal of Gastroenterology, online August 28.
Reuters Health Information

U.S. Cuts Vaping-Related Illness Total Under Refined Case Definition

Sat, 14 Sep 2019 00:17:35 +0000

U.S. health officials on Thursday cut the number of lung illnesses linked to e-cigarettes and vaping products under investigation to 380 as states began assessing patients based on a narrower case definition issued late last month by the Centers for Disease Control and Prevention (CDC).
Reuters Health Information

Proposed Military Cuts Ignite Worries for Medical Education

Fri, 13 Sep 2019 19:38:29 +0000

AAMC's chief academic leader, a former Army officer, says that, if medical education in the military had to be outsourced to the civilian side, there wouldn't be enough training spots.
Medscape Medical News

Newer MS Therapies Superior to Injectables in Children

Fri, 13 Sep 2019 17:11:13 +0000

A first of its kind observational study compares effectiveness of initial treatment choices for children and adolescents with multiple sclerosis — and finds an advantage for newer agents.
Medscape Medical News

Breast Cancer Drugs May Severely Inflame Lungs, FDA Warns

Fri, 13 Sep 2019 17:24:37 +0000

CDK 4/6 inhibitors may cause rare but severe inflammation of the lungs. Clinicians asked to watch for new or worsening respiratory symptoms.
News Alerts

ESC Offers Updated Guidance on Acute Pulmonary Embolism

Fri, 13 Sep 2019 16:16:54 +0000

The guidelines recommend direct oral anticoagulants as first-line treatment for most patients after PE and take on specific problems and vulnerable patient groups.
Medscape Medical News

Reduce Measles Exposure in Outpatient Facilities: Here's How

Fri, 13 Sep 2019 16:30:17 +0000

CDC researchers identified strategies used to decrease exposure to measles in outpatient facilities that lack negative-pressure rooms.
Medscape Medical News

Intensive BP Goals Pose No Risk for Orthostatic Hypotension

Fri, 13 Sep 2019 16:37:49 +0000

For patients with prior stroke, a lower systolic blood pressure goal actually reduced the occurrence of orthostatic hypotension compared to standard goals, a new analysis shows.
Medscape Medical News

ED Docs Can Identify Patients Likely to Die Within 1 Month

Fri, 13 Sep 2019 15:46:25 +0000

Emergency department physicians can identify individuals who might benefit from palliative care when asked one question.
Medscape Medical News

Are Patients the Next Cyberattack Targets?

Fri, 13 Sep 2019 14:26:22 +0000

When will cyber criminals make the jump to medical device hacking?
Medscape Medical News

FDA, EU Investigating Probable Carcinogen in Heartburn Meds

Fri, 13 Sep 2019 13:52:05 +0000

Drug regulators in the US and Europe find the probable carcinogen NDMA in heartburn medicines containing ranitidine, reminiscent of the 'sartan' contamination saga.
News Alerts

Anti-CD19 MAb Trial Halted Early for Benefit in NMO

Fri, 13 Sep 2019 11:58:49 +0000

Inebilizumab is one of three new treatments for neuromyelitis optica — which have all shown striking degrees of efficacy — but are likely to be much more expensive than current mainstay therapy.
Medscape Medical News

Expanding Home Dialysis for Kidney Disease Feasible and Safe

Fri, 13 Sep 2019 12:48:08 +0000

Expanding home dialysis as an initial therapy for end-stage renal disease is feasible and safe, and produces better outcomes among patients than starting them on center-based hemodialysis.
Medscape Medical News

VA Hospitals Ban Smoking, But Employee Union Objects

Fri, 13 Sep 2019 10:20:56 +0000

The Department of Veterans Affairs will ban all types of smoking at its hospitals and other facilities, starting next month. A union representing 260,000 VA employees says that the ban is in violation of their contract, which allows smoking outdoors.
Medscape Medical News

Bariatric Surgery Tied to Less MACE in Obesity, Diabetes

Fri, 13 Sep 2019 07:14:21 +0000

Patients with obesity and type 2 diabetes who underwent bariatric surgery were less likely than those on medical treatment to have coronary, cerebrovascular or kidney events, in new observational data.
Medscape Medical News

Антибиотики класса фторхинолонов могут привести к проблемам с сердцем

Fri, 13 Sep 2019 12:00:47 +0000

Канадские ученые впервые продемонстрировали связь между двумя типами проблем с сердцем и одним из наиболее часто назначаемых классов антибиотиков – фторхинолонами.

All About Medicare for All Again as Healthcare Leads Debate

Fri, 13 Sep 2019 06:09:59 +0000

The topic of healthcare may have led off the latest debate, but after discussing Medicare for all, many other pressing health issues didn't make the cut.
Medscape Medical News

Витамин Е не обязательно «заедать» жиром для его усвоения

Fri, 13 Sep 2019 09:17:18 +0000

Новое американское исследование позволяет подкорректировать рекомендации относительно употребления витамина Е. Хотя он и является жирорастворимым, но для его усвоения теперь не обязательно потреблять жир вместе с витаминами.

Antibody Monotherapy Shows Promise in Neuromyelitis Optica

Thu, 12 Sep 2019 20:49:29 +0000

Satralizumab as monotherapy is effective vs placebo for reducing risk of relapses in patients with autoimmune neuromyelitis optica spectrum disorder (NMOSD), new research suggests.
Medscape Medical News

PCPs Lack Awareness of Prediabetes, Survey Finds

Thu, 12 Sep 2019 19:38:44 +0000

Important patient and provider gaps persist in the management of prediabetes; however, shared decision making with pharmacists and other healthcare providers could help close those gaps.
Medscape Medical News

[Series] Challenges and controversies in childhood tuberculosis

Thu, 12 Sep 2019 23:00:09 +0000

Children bear a substantial burden of suffering when it comes to tuberculosis. Ironically, they are often left out of the scientific and public health advances that have led to important improvements in tuberculosis diagnosis, treatment, and prevention over the past decade. This Series paper describes some of the challenges and controversies in paediatric tuberculosis, including the epidemiology and treatment of tuberculosis in children. Two areas in which substantial challenges and controversies exist (ie, diagnosis and prevention) are explored in more detail.

[Series] Management of drug-resistant tuberculosis

Thu, 12 Sep 2019 23:00:09 +0000

Drug-resistant tuberculosis is a major public health concern in many countries. Over the past decade, the number of patients infected with Mycobacterium tuberculosis resistant to the most effective drugs against tuberculosis (ie, rifampicin and isoniazid), which is called multidrug-resistant tuberculosis, has continued to increase. Globally, 4·6% of patients with tuberculosis have multidrug-resistant tuberculosis, but in some areas, like Kazakhstan, Kyrgyzstan, Moldova, and Ukraine, this proportion exceeds 25%.

[Clinical Picture] Catamenial pneumothorax: a cause of monthly breathlessness

Thu, 12 Sep 2019 23:00:09 +0000

A 41-year-old woman presented to our hospital complaining of breathlessness and pain in the right side of her chest. She said that the problem was not new and that it happened every time she had her period: she had begun menstruating 24 h earlier.

[Articles] Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis

Thu, 12 Sep 2019 23:00:09 +0000

There are some efficacy differences between antipsychotics, but most of them are gradual rather than discrete. Differences in side-effects are more marked. These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients' medical problems, and preferences.

[Articles] Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

Thu, 12 Sep 2019 23:00:09 +0000

In patients with normal G6PD, 7-day primaquine was well tolerated and non-inferior to 14-day primaquine. The short-course regimen might improve adherence and therefore the effectiveness of primaquine for radical cure of P vivax malaria.

[Articles] Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

Thu, 12 Sep 2019 23:00:09 +0000

In adults with mild to moderate asthma, budesonide–formoterol used as needed for symptom relief was more effective at preventing severe exacerbations than maintenance low-dose budesonide plus as-needed terbutaline. The findings support the 2019 Global Initiative for Asthma recommendation that inhaled corticosteroid–formoterol reliever therapy is an alternative regimen to daily low-dose inhaled corticosteroid for patients with mild asthma.

[Department of Error] Department of Error

Thu, 12 Sep 2019 23:00:09 +0000

Huhn M, Nikolakopoulou A, Schneider-Thoma J, et al. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet 2019; 394: 939–51—In this Article, the comparison between zotepine and haloperidol in figure 3 has been corrected to “0·08 (–0·19 to 0·36)”. The Declaration of Interests and the Acknowledgments have been updated to detail funding for the work and for Andrea Cipriani from the National Institute for Health Research.

[Department of Error] Department of Error

Thu, 12 Sep 2019 23:00:09 +0000

The Lancet. Improving occupational health in China. Lancet 2019; 394: 443—In this Editorial, the sentence “More than 975 000 cases of occupational illness occurred in 2018,” was incorrect and should have been “The total number of reported occupational cases up until 2018 was 97 500”. This correction has been made to the online version as of Aug 23, 2019.

[Department of Error] Department of Error

Thu, 12 Sep 2019 23:00:09 +0000

Fanaroff AC, Califf RM, Lopes RD. High-quality evidence to inform clinical practice. Lancet 2019; 394: 633–34—In this Correspondence, findings from an analysis of current cardiovascular guidelines were incorrectly presented. In the following sentence, the percentages of guidelines that were based on evidence from randomized controlled trials have been corrected: “Framed this way, findings from an analysis of current cardiovascular guidelines, which showed that less than 10% of American College of Cardiology and American Heart Association and less than 15% of European Society of Cardiology guideline recommendations were based on evidence from RCTs…”.

[Department of Error] Department of Error

Thu, 12 Sep 2019 23:00:09 +0000

The Lancet. Fear and uncertainty around Kashmir's future. Lancet 2019; 394: 542—In this Editorial, the margin URL to a report by Médecins Sans Frontières was invalid and has been replaced with a correct URL. This correction has been made to the online version as of Aug 23, 2019.

[Correspondence] Developing country: an outdated term in The Lancet

Thu, 12 Sep 2019 23:00:09 +0000

In January, 2019, two years after his death, Hans Rosling's final book, Factfulness,1 was published in translation in Japan. It quickly became a bestseller. As Rosling mentioned in the book, he was opposed to dividing the world into two types of countries: developed and developing; high-income and low-income; us and them. In using the words developing country, Rosling explained that we live with an outdated mindset. The progress and achievements of the countries labelled as developing are so diverse that it would be misleading to lump all the countries together based on a single criterion.

[Correspondence] Militaries and global health – Authors' reply

Thu, 12 Sep 2019 23:00:09 +0000

We appreciate the comments by Jonathan Kennedy and colleagues referencing some of the challenges inherent in military engagement in global health. Kennedy and colleagues state that the Geneva Conventions have become outdated given the realities of current conflicts, and believe only a redefinition and redesign of international humanitarian law can address the weaknesses of the current system. We agree that new ways of war require re-envisioning international humanitarian law and a failure to fully adapt and broaden these requirements to current circumstances are key weaknesses.

[Correspondence] Militaries and global health

Thu, 12 Sep 2019 23:00:09 +0000

We can appreciate the temptation for public health practitioners and researchers to partner with our well funded militaries and police to deliver health benefits. Still, we warn of the danger in pursuing such pragmatic partnerships.

[Correspondence] Militaries and global health

Thu, 12 Sep 2019 23:00:09 +0000

We share Joshua Michaud and colleagues'1 concern regarding military actors' violations of international humanitarian law, particularly attacks on civilians, health workers and health facilities. However, we believe that discussions about how best to respond to such violations would benefit from a nuanced approach.

[Correspondence] Polio vaccination controversy in Pakistan

Thu, 12 Sep 2019 23:00:09 +0000

The Global Polio Eradication Initiative reports Pakistan as the only country with consistent barriers preventing vaccination and the eradication of the disease. The barriers are linked to religious extremism and sometimes to global political interests.1 The Government of Pakistan has managed the issues by involving social mobilisers2 and religious leaders3 and by deploying police officials1 to ensure the smooth running of the vaccination programmes. However, the emergence of 53 new polio cases in the country between January and August, 2019, which is more cases than in past 3 years,4 has led to calls for additional stringent measures to cope with the situation in the years ahead.

[Correspondence] Parasitic encephalitis in immunocompetent individuals – Authors' reply

Thu, 12 Sep 2019 23:00:09 +0000

We thank Amir Abdoli for his comments. Our intention in this Seminar1 was to bring together knowledge about the most important infectious causes, along with information about the rapidly growing field of autoimmune encephalitis, to provide a single comprehensive approach. Previously, the two have been dealt with rather separately, despite the large overlap in clinical features. As indicated in the titles of the tables in the Seminar,1 selected causes of encephalitis in immunocompetent individuals were presented.

[Correspondence] Parasitic encephalitis in immunocompetent individuals

Thu, 12 Sep 2019 23:00:08 +0000

Arun Venkatesan and colleagues1 adeptly presented the infectious and autoimmune causes of acute encephalitis in immunocompetent adults. According to the authors, viruses are the largest group of acute encephalitis causative agents. The authors also listed bacterial, fungal, and parasitic causes of acute encephalitis. In the parasitic section, Acanthoemeba species, Naegleria fowleri, Balamuthia mandrillaris, and Baylisascaris procyonis are listed. However, it seems that some of the important parasitic causes of acute encephalitis are missed (appendix).

[Correspondence] Recurring acute encephalitis syndrome outbreaks in Bihar, India

Thu, 12 Sep 2019 23:00:08 +0000

The death of 154 undernourished children from acute encephalitis syndrome in a short period of 3 weeks1 is deeply concerning. The World Report by Patralekha Chatterjee1 is a timely update on a situation that recurs almost every year in Bihar, India. Chatterjee rightly pinpoints undernutrition, inadequate health facilities, and poor awareness among the local population as contributing factors to these deaths.

[Correspondence] A tuberculosis-free world: is it a delusion? – Authors' reply

Thu, 12 Sep 2019 23:00:08 +0000

We agree with Sachin Atre that building a tuberculosis-free world requires circumspect reflection on the failures of the past. Doing so also demands renewed ambition; only with sufficient political will and financial investments can we end the epidemic. As we underscore in the Commission,1 failure to end the epidemic is morally inexcusable and economically indefensible. We must therefore move beyond the narrow view that tuberculosis is the problem of the world's poorest societies and recognise that the disease is a universal health problem for an interdependent global population.

[Correspondence] A tuberculosis-free world: is it a delusion?

Thu, 12 Sep 2019 23:00:08 +0000

I read with interest The Lancet Commission on tuberculosis.1 Tuberculosis, the leading infectious cause of mortality in the world, resulting in nearly 10 million cases and 1·6 million annual deaths, has made the human race suffer for more than a century.2 Despite the existence of cutting-edge technologies and treatments, we are not able to achieve control over the disease. I have some fundamental questions for the global community of tuberculosis researchers, policymakers, and programme planners, especially as we move towards the ambitious goal of making the world tuberculosis-free.

[Perspectives] Battling for life: the wartime work of Janet Vaughan

Thu, 12 Sep 2019 23:00:08 +0000

In A Room of One's Own, Virginia Woolf fabricated an imaginary novel about two young women who worked in a medical laboratory. Pretending that this fictional book actually existed, she described her feelings on reading that Chloe and Olivia “were engaged in mincing liver, which is, it seems, a cure for pernicious anaemia”. In real life, Woolf's friend and distant relative Janet Vaughan was employed as a clinical pathologist at University College Hospital, where she had secretly arranged for anaemic patients to be given liver.

[Perspectives] The pain and glory of ageing

Thu, 12 Sep 2019 23:00:08 +0000

Cinematic reflection on ageing is often about the extremes of life, such as in Pixar's Up, The Company of Strangers by Cynthia Scott, and Michael Haneke's Amour. But the transition from middle age to early old age is also a key time for reflection, recalibration, and refocus of the meaning of life and reconciliation of suffering, mistakes, and successes.

[Perspectives] A doctor's choice

Thu, 12 Sep 2019 23:00:08 +0000

Does a doctor always know what is in the best interests of a patient? And should the personal values of a patient be subordinated to the medical perspective in all cases? Doctors' ethical conundrums have featured in plays such as Henrik Ibsen's An Enemy of the People (1882) and George Bernard Shaw's The Doctor's Dilemma (1906). In 1912, Arthur Schnitzler's Professor Bernhardi took the exploration of medical ethics to a new level by introducing issues of religion and the clash between medical decisions and growing antisemitism in Europe.

[Perspectives] Towards a tricorder for diagnosing paediatric conditions

Thu, 12 Sep 2019 23:00:08 +0000

Paediatric patients introduce a unique challenge for health care: information about symptoms in infants and children is usually obtained second-hand from the parents. Typically, diagnosis of paediatric conditions relies on physical examination and objective tests during a visit with a health professional. Yet digital diagnostics are now in development for assessing some common paediatric conditions that are not serious or life-threatening. These technologies could have the potential to change elements of paediatric care.

[World Report] Health providers urged to help to eradicate modern slavery

Thu, 12 Sep 2019 23:00:08 +0000

Millions of people are victims of modern slavery, and experts say that countries are failing to stop it. Should health-care workers do more? John Zarocostas reports.

[Comment] Offline: Why we must listen to critical friends

Thu, 12 Sep 2019 23:00:08 +0000

The UK is becoming a “narrowly nationalistic country”. Political instability is endemic. The nation is approaching a “second civil war”. Extreme remarks from an extreme personality? Hardly. Eliza Manningham-Buller worked for MI5, Britain's Security Service, for over 30 years, ending her career as its Director General from 2002 to 2007. She now sits in the House of Lords and is Chair of the Wellcome Trust. Manningham-Buller is the quintessential insider's insider. She was delivering the John Snow Society's annual Pumphandle Lecture last week at the London School of Hygiene & Tropical Medicine.

[Comment] Financing universal health coverage: four steps to go from aspiration to action

Thu, 12 Sep 2019 23:00:08 +0000

A UN High-Level Meeting on Universal Health Coverage (UHC) will be convened during the 74th session of the UN General Assembly on Sept 23, 2019. Most countries support the aspirations of UHC and have committed to its principles.1 Less has been articulated about how to deliver this goal. In many low-income and middle-income countries, health-care systems are inadequate and providers rely on patients' out-of-pocket payments. Those who are poor and sick cannot access care or avoid seeking care because they are unable to pay.

[Comment] Balancing body and mind: selecting the optimal antipsychotic

Thu, 12 Sep 2019 23:00:08 +0000

The burden of schizophrenia remains high, with one in 100 people affected globally over a lifetime.1 Symptoms are disabling, with auditory hallucinations, delusions, lack of motivation, cognitive impairment, and functional deficits. Despite advances in our understanding of the biological underpinnings of the illness, cure remains elusive. Antipsychotic medications are the mainstay of pharmacological treatment, but selecting the optimal medication for the individual patient is a delicate balance between efficacy and physical side-effects.

[Comment] A shorter course for anti-relapse therapy against vivax malaria

Thu, 12 Sep 2019 23:00:08 +0000

Although Plasmodium falciparum causes the greatest number of global malaria infections and deaths, the impact of infection with Plasmodium vivax, the dominant human malaria parasite outside of Africa, is large, with an estimated 7·4 million cases in 2017.1,2 A particular challenge with P vivax infection is hypnozoites: dormant liver-stage parasites that are not eliminated by standard antimalarial treatments. Hypnozoites do not cause clinical illness, but without therapy that targets them, P vivax infections will commonly relapse, with recurrent symptomatic blood-stage infections weeks to months after the primary infection.

[Comment] As-needed β agonist-inhaled corticosteroid in mild asthma

Thu, 12 Sep 2019 23:00:08 +0000

Asthma is remarkably prevalent, although most patients have mild, intermittently symptomatic disease. For these patients, as-needed short-acting β agonists (SABAs) with or without maintenance inhaled corticosteroids have formed the backbone of therapy. Yet adherence to daily maintenance regimens is often poor, especially in rarely symptomatic disease, such that alternative approaches are needed. In The Lancet, Jo Hardy and colleagues1 present the results of PRACTICAL, a study that investigated the real-world efficacy of single-inhaler reliever therapy in adults with mild to moderate asthma.

[Editorial] Tuberculosis needs accelerated and continued attention

Thu, 12 Sep 2019 23:00:08 +0000

Ahead of the annual meeting of the European Respiratory Society (Madrid, Spain, Sept 28–Oct 2), we publish together with The Lancet Respiratory Medicine a three-part Series on tuberculosis. This Series, which focuses on the management of drug-resistant tuberculosis, challenges in childhood tuberculosis, and the state of vaccine development, will be discussed in a special symposium at the conference. Tuberculosis is now the most common and deadly infectious disease. An estimated 1·6 million people die from the disease annually, including 230 000 children.

[Editorial] Let's talk about dementia

Thu, 12 Sep 2019 23:00:07 +0000

On Sept 1, kicking off World Alzheimer's Month, Alzheimer's Disease International joined forces with the Pan American Health Organization, launching Let's Talk About Dementia, a campaign aiming “to demystify dementia and to get people talking”. The ambition is to encourage discussion in families and with health providers to reduce the stigma associated with Alzheimer's disease and all forms of dementia. Events elsewhere include the Age Against the Machine festival in the UK, which offers a practical workshop on making homes, workplaces, or projects dementia-friendly and a performance of How to Keep Time, which looks at the effects of dementia on speech, memory, and family life.

[Editorial] Patient safety: too little, but not too late

Thu, 12 Sep 2019 23:00:07 +0000

The first-ever World Patient Safety Day is taking place on Sept 17, 2019. Every day, countless patients worldwide are put at risk by unsafe care and end up requiring treatment for ailments caused by the very system that was supposed to help them get better. Protecting patients from errors, injuries, accidents, and infections is an essential goal for every health system, but no health system has so far successfully addressed patient safety.

FDA Clears GE Healthcare's AI Triage Algorithm on X-Ray Device

Thu, 12 Sep 2019 18:13:53 +0000

The algorithm analyses chest x-rays for pneumothorax and flags suspected cases for radiologists to prioritize.
FDA Approvals

FDA OKs Tenapanor for IBS With Constipation in Adults

Thu, 12 Sep 2019 18:39:24 +0000

Two phase 3 trials demonstrated a statistically significant reduction in constipation and abdominal pain in adults with IBS-C treated with tenapanor.
FDA Approvals

FDA OKs Mepolizumab for Younger Children With Severe Asthma

Thu, 12 Sep 2019 16:18:54 +0000

Nucala is the first biologic approved in the US for children aged 6 to 11 years with severe eosinophilic asthma.
News Alerts

Biomarker Tool Shows Promise for Diagnosing Post-Traumatic Stress Disorder

Thu, 12 Sep 2019 02:40:14 +0000

A diagnostic panel of 28 biomarkers confirmed a post-traumatic stress disorder (PTSD) diagnosis in male combat veterans with 77% accuracy, a phase 2 study revealed.
Reuters Health Information

Better Outcomes Seen With Early Restart of Anticoagulants After GI Bleeding

Thu, 12 Sep 2019 02:44:04 +0000

Early resumption of anticoagulant or antiplatelet therapy after a gastrointestinal bleeding event is associated with better outcomes overall, researchers in Spain report.
Reuters Health Information

FDA Clears HeartFlow Planner Virtual Modeling Tool for CAD

Thu, 12 Sep 2019 15:25:37 +0000

The HeartFlow Planner, used alongside the HeartFlow Analysis, allows interventional cardiologists to virtually model different clinical scenarios in real time, the company says.
FDA Approvals

Gender Identify Conversion Efforts Up Lifetime Suicidality Risk

Thu, 12 Sep 2019 15:30:12 +0000

A new study suggests that gender identity conversion therapy is even more harmful when begun before age 10.
Medscape Medical News

Karolinska VP Resigns Amid Scientific Misconduct Allegations

Thu, 12 Sep 2019 14:04:20 +0000

An investigation alleging that the vice-president of the Karolinska Institutet engaged in careless research tantamount to scientific misconduct has led to her being relieved of her role.
Medscape Medical News

Long-Term Beta Blockers Post-CABG Questioned, Even With Low LVEF

Thu, 12 Sep 2019 14:10:17 +0000

Use of guideline-recommended meds started out high after CABG but waned over time in a registry study that, controversially, also saw no survival benefit to long-term postoperative beta blockers.
Medscape Medical News

The Latest Advice on Vitamin D for MS

Thu, 12 Sep 2019 13:08:02 +0000

The recurring question of whether to give MS patients vitamin D supplementation was the subject of one of the first 'hot topics' to be debated at the ECTRIMS meeting currently underway.
Medscape Medical News

Indictments Handed Down in $8 Million Mental Health Billing Scheme

Thu, 12 Sep 2019 12:24:15 +0000

The Louisiana owner of a mental health counseling center has been indicted on multiple counts of healthcare and wire fraud, as well one count of paying kickbacks, the Department of Justice announced.
Medscape Medical News

Is There a Downturn in New Cases of Diabetes in Some Regions?

Thu, 12 Sep 2019 12:47:40 +0000

Systematic review looking at trends in new cases of diabetes shows some stable and declining rates, but editorialist is skeptical of the findings.
Medscape Medical News

Здоровый дневной сон улучшает здоровье сердца

Thu, 12 Sep 2019 18:00:26 +0000

Хорошие новости для любителей поспать днем - новое исследование показало, что дневной сон, раз или два раза в неделю, может снижать риск инфаркта и инсульта.

No Easy Route to Universal Healthcare in the United States

Thu, 12 Sep 2019 10:50:02 +0000

The roadmap to universal healthcare in the United States requires many paths to the destination, say experts.
Medscape Medical News

Hospital-Owned Physician Practices Raise Costs but Not Quality

Thu, 12 Sep 2019 11:04:15 +0000

Patients pay $280 more on average per year with hospital-affiliated practices, but they're not getting higher-quality care by most measures, a new study suggests.
Medscape Medical News

Does Your Medical Center Have a Contract With ICE? These Do.

Thu, 12 Sep 2019 11:35:33 +0000

A Medscape analysis found that several major medical centers have contracts with CBP or ICE to provide services they say will improve conditions for migrants at the border; opponents are outraged that these institutions are supporting a system they believe abuses detainees.
Medscape Medical News

Ученые обнаружили причины возрастного набора веса

Thu, 12 Sep 2019 17:07:35 +0000

В процессе старения замедляется скорость липидного обмена в жировой ткани, приводя к набору веса, даже если нет изменений в питании или уровне физической активности, выяснили шведские и французские ученые.

Medical Devices Very Vulnerable to Hacking, FDA Experts Warn

Thu, 12 Sep 2019 07:23:24 +0000

Networked medical devices are increasingly prone to cybersecurity threats, according to a US Food and Drug Administration panel of experts. How to communicate with patients about the problem is important.
Medscape Medical News

'Strongest Evidence Yet' That Diabetes Drugs Are Renoprotective

Thu, 12 Sep 2019 09:59:58 +0000

Meta-analysis of four major trials in patients with type 2 diabetes shows significant renal benefit of SGLT2 inhibitors, even in patients with reduced kidney function.
Medscape Medical News

'Medium' Dose of Common ADHD Drug Most Effective for Kids

Thu, 12 Sep 2019 10:08:16 +0000

Clinicians are being warned against overtreating children with methylphenidate, and to focus on neurocognitive function over behavior, based on results of a new meta-analysis.
Medscape Medical News

A 'Unicorn' Pushes for Diversity in Dermatology

Thu, 12 Sep 2019 09:38:22 +0000

Years-long efforts to diversify dermatology, one of the least diverse medical specialties, are gaining momentum.
Medscape Medical News

Medical Devices Very Vulnerable to Hacking, FDA Experts Warn

Thu, 12 Sep 2019 07:23:24 +0000

Networked medical devices are increasingly prone to cybersecurity threats, according to a US Food and Drug Administration panel of experts. How to communictae with patients about the problem is important.
Medscape Medical News

Невысокие люди имеют больше шансов заболеть диабетом 2 типа

Thu, 12 Sep 2019 09:51:40 +0000

Немецкие ученые выяснили, что рост связан с риском развития диабета 2 типа – у людей низкого роста выше вероятность заболеть

'It Is Time to Stop Vaping' -Kansas Reports 6th U.S. Death Linked to Mystery Illness

Thu, 12 Sep 2019 00:00:30 +0000

A Kansas resident was the sixth person to die in the United States of a mysterious respiratory illness related to vaping, state officials said on Tuesday, as public health officials scrambled to understand a nationwide health problem.
Reuters Health Information

Language-Network Connectivity Disrupted in Primary Progressive Aphasia

Wed, 11 Sep 2019 23:43:56 +0000

Primary progressive aphasia is associated with perturbations of connectivity within components of the brain's language network, researchers report.
Reuters Health Information

Not So Fast: U.S. CDC Isn't Ready to Blame Illicit 'Street Vapes' for Illnesses

Wed, 11 Sep 2019 23:34:38 +0000

U.S. health investigators are casting a wide net to understand what is sickening hundreds of vapers across the country and still have not ruled out any product on the market, even as vaping industry officials highlight the potential role of illegal cannabis products.
Reuters Health Information

Facebook Bans Self-Harm Images in Fight Against Suicide

Wed, 11 Sep 2019 23:30:56 +0000

Facebook Inc will no longer allow graphic images of self-harm on its platform as it tightens its policies on suicide content amid growing criticism of how social media companies moderate violent and potentially dangerous content.
Reuters Health Information

U.S. EPA Chief to Reduce Agency-Funded Animal Testing

Wed, 11 Sep 2019 23:25:29 +0000

U.S. Environmental Protection Agency Administrator Andrew Wheeler said Tuesday he was signing a memo to reduce agency-funded animal testing, vowing to almost completely end the practice by 2035.
Reuters Health Information

Healthcare Sector Major Contributor to Global Climate Crisis

Wed, 11 Sep 2019 20:02:16 +0000

A new international report shows that the healthcare industry, from hospitals to its supply chain, is one of the largest greenhouse gas emitters on the planet.
Medscape Medical News

Feds Levy First-Ever Fine to Hospital for Not Sharing Patient Info

Wed, 11 Sep 2019 17:06:09 +0000

First-ever settlement of this kind might be a shot across the bow for healthcare providers; physician practices should also pay attention, says expert.
Medscape Medical News

MESEMS: No Reduction in MS Lesions With Stem Cell Therapy

Wed, 11 Sep 2019 15:49:38 +0000

Although the primary outcome of a multinational phase 2 study was negative, researchers said promising secondary findings support the use of mesenchymal stem cells in patients with MS.
Medscape Medical News

87 Years Old, One Sex Partner, Diagnosed With AIDS

Wed, 11 Sep 2019 15:56:50 +0000

As the nation takes steps to end the HIV epidemic, the search for every undiagnosed person with HIV becomes harder, so health departments are developing innovative ways to get patients tested.
Medscape Medical News

Hypertension Common Among Young Black Women

Wed, 11 Sep 2019 15:16:15 +0000

In a new NHANES analysis, nearly half of black women aged 18 to 35 had hypertension, vs fewer than 30% of young white women.
Medscape Medical News

White House Announces Plans to Ban Flavored E-Cigarettes From Market

Wed, 11 Sep 2019 15:34:00 +0000

U.S. President Donald Trump told reporters on Wednesday that the country has a problem with vaping, and his top health official said the Food and Drug Administration intends to remove all flavored e-cigarettes from the market.
Reuters Health Information

ORION-11: 50% Reduction in LDL With Twice-Yearly Injection

Wed, 11 Sep 2019 13:29:25 +0000

Results of the ORION-11 study with the new RNA cholesterol-lowering agent inclisiran show sharp drops in LDL with safety consistent with previous studies.
Medscape Medical News

Cardiac 'Shrinkage' on Sacubitril/Valsartan May Rival CRT in HF

Wed, 11 Sep 2019 13:37:07 +0000

LV volumes fell and LVEF rose, often 10 points or more, after a year on the ARNI. That approaches gains on cardiac resynchronization therapy, "the reverse-remodeling champion," a researcher notes.
Medscape Medical News

Success of Quitting Smoking When Paired With Lung Cancer Screen

Wed, 11 Sep 2019 11:08:56 +0000

Smoking cessation programs in general persuade probably at best about 10% of participants to quit, but a new approach in Vancouver has raised this to 27% .
Medscape Medical News

ВОЗ: два стакана диетических сладких напитков в день повышают риск преждевременной смерти

Wed, 11 Sep 2019 17:01:53 +0000

Употребление всего лишь двух стаканов диетических (содержащих заменители сахара) безалкогольных напитков в день увеличивает риск ранней смерти.

Курение онкобольных ухудшает прогноз на выздоровление

Wed, 11 Sep 2019 17:15:44 +0000

Международная ассоциация по изучению рака легких призывает в своей Декларации обратить внимание на проблему важности прекращения употребления табака после того, как диагностирован рак

Obesity-Associated Cancer Shifting to Younger People

Wed, 11 Sep 2019 09:30:07 +0000

During the past 17 years, new cases of obesity-associated cancers have been increasing among younger age groups, with racial and ethnic minorities disproportionately affected.
Medscape Medical News

Are You Seeing Benefits or Harms From Marijuana Use?

Wed, 11 Sep 2019 09:44:51 +0000

As more US states legalize medical or recreational marijuana, use is increasing, and so may be potential benefits and harms.
Medscape Reader Polls

FDA OKs Easy-to-Use Glucagon Rescue Pen for Hypos in Diabetes

Wed, 11 Sep 2019 08:05:50 +0000

Two easy-to-use new glucagon rescue products, an autoinjector pen and a prefilled syringe, have been approved in the US for use in severe hypoglycemia in diabetes patients aged 2 years and older.
FDA Approvals

Gluten Does Not Cause GI Symptoms in Healthy People: Study

Wed, 11 Sep 2019 06:54:02 +0000

According to a recent study, gluten does not cause gastrointestinal symptoms in people without a gluten sensitivity.
Medscape Medical News

В половине случаев тяжелобольные дети остаются без лекарств из-за бюрократических проволочек

Wed, 11 Sep 2019 10:33:54 +0000

Благотворительные фонды регулярно вынуждены собирать для своих подопечных средства на лекарственные препараты, которые обязаны им выдаваться за счет средств бюджета. Проблема кроется не только в запутанности и несовершенстве законодательной базы, но и во многом в неповоротливости государственной системы обеспечения лекарствами, в особенности – на региональном уровне.

Anxiety in Pregnancy Linked to Hyperactivity in Offspring Teens

Tue, 10 Sep 2019 18:20:40 +0000

High maternal anxiety during or after pregnancy may be a "window of opportunity" to prevent hyperactivity in their children, researchers say.
Medscape Medical News

Neuroprosthetic Leg Restores Feeling, Eases Phantom Pain

Tue, 10 Sep 2019 16:58:41 +0000

A neural prosthetic leg that restores sensory feedback can also improve walking performance and reduce phantom limb pain in above-knee amputees, a new proof-of-concept study suggests.
Medscape Medical News

HIV Care Teams Shy Away From Uncomfortable Conversations

Tue, 10 Sep 2019 15:51:03 +0000

No one with an undetectable viral load has transmitted HIV to a sexual partner, research shows, but not all care teams are at ease discussing the topic with their patients.
Medscape Medical News

Remote Ischemic Conditioning Fails in MI: CONDI-2/ERIC-PPCI

Tue, 10 Sep 2019 16:23:28 +0000

Still, despite definitive evidence of neutral effect on clinical outcomes in STEMI patients receiving contemporary PCI, experts caution against abandoning the cheap and easy to perform intervention.
Medscape Medical News

Life's Simple 7: Not Simple at All?

Tue, 10 Sep 2019 14:19:14 +0000

Despite the AHA program's aim to change people’s lifestyles, cardiovascular health got worse over time, not better, except for young non-Hispanic white females, a new study shows.
Medscape Medical News

Heparin Dosing Oddities at PCI: A 'Red Flag' Raises Questions

Tue, 10 Sep 2019 14:29:12 +0000

Cath-lab clinicians have seen familiar heparin dosing fail to reach target ACT, sometimes with costs. It's all anecdotal, but they wonder if some heparin is 'diluted' and urge such cases be reported.
Medscape Medical News

'Possibility of Cure' for Some Patients With CLL

Tue, 10 Sep 2019 12:50:53 +0000

Ibrutinib is rapidly changing the treatment landscape in chronic lymphocytic leukemia (CLL), and experts are now talking about the possibility of a cure for some patients.
Medscape Medical News

Gavi Vaccine Alliance Wins 2019 Lasker Public Service Award

Tue, 10 Sep 2019 13:27:41 +0000

The Vaccine Alliance is being honored for providing sustained access to childhood vaccines around the globe, saving millions of lives and highlighting the power of immunization to prevent disease.
Medscape Medical News

Как ухаживать за родственником, перенесшим инфаркт

Tue, 10 Sep 2019 19:08:40 +0000

Человек пережил сердечную катастрофу и благополучно вернулся домой. Родные счастливы, что все обошлось, но не знают, какой образ жизни теперь вести сердечнику, какие позволительны нагрузки, какой диеты придерживаться. Боятся, что сердце опять прихватит. И совершают пагубные ошибки. Как действовать правильно, объясняет кардиолог столичной ГКБ №17 Эркин Мирзоев.

Diabetes Risk Plummets by 75% When Multiple Risk Factors Tackled

Tue, 10 Sep 2019 11:04:28 +0000

Systemic review of more than 1 million people shows dramatic impact of overall healthy lifestyle in preventing type 2 diabetes and reducing complications among those with diabetes.
Medscape Medical News

Microbiome May Identify New Types of Hypertension

Tue, 10 Sep 2019 10:18:42 +0000

Hypertension accompanied by depression may be an entirely different disorder from hypertension that develops in those without depression, analysis of the gut microbiome suggests.
Medscape Medical News

Face-to-Face Teamwork Key to Job Satisfaction in Primary Care

Tue, 10 Sep 2019 08:43:42 +0000

Face-to-face team communication in primary care clinics improves job satisfaction among clinicians and staff, whereas team communication via the electronic health record does not.
Medscape Medical News

Нездоровая диета чревата слепотой

Tue, 10 Sep 2019 14:35:14 +0000

Ученые из Бристольского университета исследовали случай с подростком, который долго питался преимущественно чипсами, белым хлебом и обработанной свининой. У него выявили пищевую оптическую нейропатию, которая привела к потере зрения. В связи с этим ученые рекомендуют врачам узнавать историю рациона питания пациентов, чтобы выявлять нейропатию на ранних стадиях.

Nearly 1 in 6 Docs Say They Make Diagnostic Errors Every Day

Tue, 10 Sep 2019 07:00:00 +0000

Nurses, NPs, and PAs made estimates similar to physicians' in a Medscape poll. Numbers vary by specialty.
Medscape Medical News

Female-Dominated Pediatrics Still Has Wage Gap

Tue, 10 Sep 2019 07:31:34 +0000

After adjusting for multiple factors, it was found that female pediatricians make $8000 a year less than their male colleagues. They also spend more time on household tasks and report less work/life balance.
Medscape Medical News

Недосыпание разрушает сексуальную жизнь

Tue, 10 Sep 2019 09:16:30 +0000

Ученые выяснили, что нарушения сна связаны с эректильной дисфункцией у мужчин, а также с проблемами с возбуждением и оргазмом у женщин. К такому выводу исследователи пришли в результате длительного наблюдения за почти 4 тысячами участников обоих полов.

rTMS Boosts Cognitive Function in Schizophrenia Plus Depression

Mon, 09 Sep 2019 20:27:09 +0000

Repetitive transcranial magnetic stimulation provides greater cognitive improvements than antidepressant therapy in patients with depression in schizophrenia, new research suggests.
Medscape Medical News

Estrogen Therapy Benefits, Harms Tied to Age, Ovary Status

Mon, 09 Sep 2019 19:32:25 +0000

Patients who were older than 60 when they started estrogen therapy did not have lower mortality risk and had more side effects, regardless of whether they had their ovaries removed.
Medscape Medical News

Hepatitis C Vaccine Blighted, Another in the Works

Mon, 09 Sep 2019 18:06:12 +0000

The second-generation vaccine is being developed by one of the members of the research team that first discovered hepatitis C.
Medscape Medical News

California Docs Charged in $115M "Cash-For-Patients" Scheme

Mon, 09 Sep 2019 18:40:28 +0000

The Department of Justice has charged two home healthcare agencies and 28 individuals — including 13 doctors — in the largest-ever cash-for-patients scheme in northern California.
Medscape Medical News

Physicians, Patients at Odds on Chronic Care Priorities

Mon, 09 Sep 2019 17:00:32 +0000

A new study shows that physicians and patients often disagree on chronic care management and on what matters most.
Medscape Medical News

Candida auris Tied to Vision Loss in Case Report

Mon, 09 Sep 2019 17:04:55 +0000

Infection with Candida auris likely led to panophthalmitis and vision loss in an immunocompromised patient, according to a new case report.
Medscape Medical News

Hypertension Rates High Among Medical Students

Mon, 09 Sep 2019 17:42:26 +0000

Single-center study found that med students have more than double the rates of stage 2 hypertension as same-age counterparts in the general population.
Medscape Medical News

Multidrug-Resistant Salmonella Newport Outbreak Linked to U.S. Beef, Mexican Soft Cheese

Mon, 09 Sep 2019 15:29:16 +0000

A recent multistate outbreak of infections with multidrug-resistant Salmonella enterica serotype Newport with decreased susceptibility to azithromycin was linked to U.S. beef and Mexican cheese, according to an epidemiologic investigation.
Reuters Health Information

Head and Neck Dermatitis Can Develop or Worsen With Dupilumab Treatment

Mon, 09 Sep 2019 15:36:56 +0000

Patients treated for atopic dermatitis with dupilumab can develop or experience worsening of head and neck dermatitis, according to a retrospective study.
Reuters Health Information

Medical Schools Fall Short on Racial Justice: Student Group

Mon, 09 Sep 2019 15:40:54 +0000

At leading U.S. medical schools, education of future doctors about racism, promotion of diversity, and service of patients of color are in need of improvement, survey results suggest.
Reuters Health Information

U.S. FDA Warns Juul Over Its Marketing Practices

Mon, 09 Sep 2019 15:01:08 +0000

The U.S. Food and Drug Administration said on Monday it had issued a warning letter to Juul Labs Inc over its marketing practices for e-cigarettes, the latest in the agency's efforts to curb the use of the devices that have become extremely popular among teens.
Reuters Health Information

What's Cooking in Diabetes? All Revealed at EASD in Barcelona

Mon, 09 Sep 2019 13:57:24 +0000

Conference attendees to hear implications for the diabetologist of latest trial data on CV and renal outcomes of newer glucose-lowering drugs, plus a first look at other new agents.
Medscape Medical News

Groupons for Medical Treatment? Welcome to Today's US Health Care

Mon, 09 Sep 2019 14:31:47 +0000

By offering an upfront cost on a coupon site like Groupon, argues one healthcare administrator, medical companies are helping to drive prices down while at the same marketing their medical businesses.
Kaiser Health News

PAs, NPs Become 'Medicare Ghosts' Billing Under a Physician

Mon, 09 Sep 2019 13:40:19 +0000

Current billing practices can make the work of physician assistants (PAs) and nurse practitioners (NPs) invisible, so their value is difficult to establish, experts report.
Medscape Medical News

Использование ополаскивателя для рта связано с уменьшением пользы от физических упражнений

Mon, 09 Sep 2019 19:17:33 +0000

Некоторые виды бактерий во рту способствуют производству оксида азота, который увеличивает диаметр кровеносных сосудов, что приводит к устойчивому снижению артериального давления после тренировки. Уничтожение бактерий антибактериальным ополаскивателем практически сводит на нет эффект тренировки, полезный для сосудов. Это показало новое британо-испанское исследование.

Esketamine Nasal Spray May Rapidly Reduce Suicidal Thoughts

Mon, 09 Sep 2019 11:26:07 +0000

Patients with depression who are at imminent risk for suicide may experience rapid benefit from esketamine nasal spray while waiting for antidepressant therapy to take effect, new research suggests.
Medscape Medical News

Wearable Devices: Compete for Best Outcomes in Workplace Program

Mon, 09 Sep 2019 11:37:36 +0000

Getting participants in a work wellness program to compete with each other yielded the greatest increases in daily step counts, and the effect was maintained, shows the largest and longest such study to date.
Medscape Medical News

FDA OKs Nintedanib (Ofev) for Rare Lung Disease

Mon, 09 Sep 2019 10:21:21 +0000

Nintedanib capsules are approved for slowing the rate of decline in pulmonary function in adults with systemic sclerosis-associated interstitial lung disease.
News Alerts

Вирус папилломы человека: пора развеять опасные мифы

Mon, 09 Sep 2019 13:54:25 +0000

Согласно данным нового британского опроса, многие жители страны не осведомлены о вирусе ВПЧ, путях его распространения и потенциальной опасности. Например, 48% женщин не думают, что они подвержены риску заболевания, если состоят в моногамных отношениях. А 52% не знают, как заражаются ВПЧ мужчины и женщины.

Растительная диета может вызывать недостаток важного для мозга вещества холина

Mon, 09 Sep 2019 09:01:48 +0000

При растительной и веганской диете человек может недополучать некоторые вещества, в частности холин, считает британский диетолог Э. Дербишир. Холин имеет решающее значение для здоровья мозга, особенно во время развития плода. Это вещество содержится в говядине, яйцах, молочных продуктах и рыбе.

Medicare Advantage Home Healthcare May Not Be Best Quality

Fri, 06 Sep 2019 16:51:08 +0000

Older Americans who get home healthcare through traditional Medicare plans may have access to better quality services than their counterparts who enroll in private plans known as Medicare Advantage, a U.S. study suggests.
Reuters Health Information

RAPID-TnT Supports 0/1-Hour Troponin T protocol, but With a Wrinkle

Fri, 06 Sep 2019 17:15:36 +0000

More rapid testing was safe overall at 30 days but may also require strategies to mitigate procedure-related myocardial injury and infarctions observed in some patients.
Medscape Medical News

When EDs Close, Patients at Nearby Hospitals Suffer

Fri, 06 Sep 2019 17:17:13 +0000

Low-occupancy emergency departments (EDs) may be better able to absorb extra patients than busier high-occupancy EDs, the researchers say.
Medscape Medical News

Weight Loss Possible With Psychiatric Drugs

Fri, 06 Sep 2019 16:43:28 +0000

Even overweight and obese people who take certain psychiatric drugs associated with weight gain may be able to shed excess pounds by focusing on healthy eating and exercise habits, a recent study suggests.
Reuters Health Information

Kick HIV Care Out of the Clinic

Fri, 06 Sep 2019 16:42:29 +0000

Communities can't end the HIV epidemic using the healthcare system they already have, warned CDC director Robert Redfield as groups debate next steps.
Medscape Medical News

Care Team Surprised by Portrayal in One-Woman Show

Fri, 06 Sep 2019 15:17:30 +0000

An oncology team went from treating a patient at their center to having a play written and performed about their care. They found out after the curtain went up on the show.
Medscape Medical News

Vaping-Related Injuries Surge; 'Consider Not Using' e-Cigs: CDC

Fri, 06 Sep 2019 15:45:13 +0000

Health officials are now investigating 450 possible cases of severe lung disease related to vaping in 33 states and one jurisdiction.
News Alerts

Google to Ban Ads for Stem Cell Therapies

Fri, 06 Sep 2019 14:33:00 +0000

The policy, which also applies to gene therapy, prohibits ads for treatments that might only be supported by early clinical studies as well as those without any evidence of benefits.
Medscape Medical News

HOPE 4: Hypertension Screening in Community Reduces CV Risk

Fri, 06 Sep 2019 14:33:34 +0000

Using nonphysician healthcare workers to screen individuals for hypertension in nonmedical settings resulted in a substantial reduction in cardiovascular disease risk in two middle-income countries.
Medscape Medical News

Even a Little Exercise Linked to a Longer Life

Fri, 06 Sep 2019 12:19:16 +0000

People who get even a small amount of exercise may be less likely to die prematurely than their more sedentary counterparts, a research review suggests.
Reuters Health Information

Trump Touts Success Against Opioids During Funding Announcement

Fri, 06 Sep 2019 11:46:29 +0000

The President announced that $2 billion would be awarded to states and localities for surveillance, prevention, and treatment, and pointed to recent CDC numbers showing reduced overdose deaths.
Medscape Medical News

New GABA Modulator Promising in Depression

Fri, 06 Sep 2019 11:39:38 +0000

Most antidepressants target monoaminergic neurotransmitters. A novel GABA modulator may open a new range of therapeutic possibilities for patients with major depression.
Medscape Medical News

No Benefit Found for HbA1c Below 6.5% in Type 1 Diabetes

Fri, 06 Sep 2019 10:23:55 +0000

Findings from a large database suggest an HbA1c target of 6.5% to 6.9% may be optimal for minimizing the risks of microvascular complications and hypoglycemia in both children and adults.
Medscape Medical News

AMA Releases 2020 CPT Codes With Almost 400 New Changes

Fri, 06 Sep 2019 07:59:28 +0000

The AMA announced 'significant enhancement' in codes for EEG monitoring services, new codes for e-visits, home BP checks, and more.
Medscape Medical News

Для здоровья сердца образ жизни важнее наследственности

Fri, 06 Sep 2019 14:09:10 +0000

Португальские ученые обнаружили, что возникновение и развитие сердечно-сосудистых заболеваний в большей степени зависит от образа жизни и привычек человека, чем от генетической предрасположенности.

Заместительная гормональная терапия связана с увеличением риска рака молочной железы

Fri, 06 Sep 2019 08:57:41 +0000

При длительном постоянном использовании заместительной гормональной терапии в период менопаузы повышается риск развития рака молочной железы, согласно метаанализу всех исследований, посвященных этой тематике. Перед приемом гормональных препаратов стоит взвесить все риски и преимущества.

AI Could Slash Diagnosis Costs in Stable Chest Pain Patients

Fri, 06 Sep 2019 02:23:03 +0000

Using an artificial intelligence-based decision support system could help clinicians treating stable chest pain patients to not only better use resources, but reduce patient stress too, say UK researchers.
Medscape News UK

Vitamin E Oil Potentially Linked to Vaping-Related Lung Illness

Thu, 05 Sep 2019 19:25:28 +0000

New York health officials claim lab results showed 'very high levels' of vitamin E acetate in nearly all cannabis-containing vape products used by individuals who developed severe respiratory illness.
Medscape Medical News

[Seminar] Pemphigus

Thu, 05 Sep 2019 23:00:09 +0000

Pemphigus consists of a group of rare and severe autoimmune blistering diseases mediated by pathogenic autoantibodies mainly directed against two desmosomal adhesion proteins, desmoglein (Dsg)1 and Dsg3 (also known as DG1 and DG3), which are present in the skin and surface-close mucosae. The binding of autoantibodies to Dsg proteins induces a separation of neighbouring keratinocytes, in a process known as acantholysis. The two main pemphigus variants are pemphigus vulgaris, which often originates with painful oral erosions, and pemphigus foliaceus, which is characterised by exclusive skin lesions.

[Seminar] Acute liver failure

Thu, 05 Sep 2019 23:00:09 +0000

Acute liver failure is a rare and severe consequence of abrupt hepatocyte injury, and can evolve over days or weeks to a lethal outcome. A variety of insults to liver cells result in a consistent pattern of rapid-onset elevation of aminotransferases, altered mentation, and disturbed coagulation. The absence of existing liver disease distinguishes acute liver failure from decompensated cirrhosis or acute-on-chronic liver failure. Causes of acute liver failure include paracetamol toxicity, hepatic ischaemia, viral and autoimmune hepatitis, and drug-induced liver injury from prescription drugs, and herbal and dietary supplements.

[Clinical Picture] A spot diagnosis! Aplasia cutis congenita in monozygotic twins

Thu, 05 Sep 2019 23:00:09 +0000

Monozygotic twins, aged 2 years, were referred to our outpatient clinic because of a hairless area 2 cm × 2 cm in a similar point on their occipital vertices (figure). The twin boys were born prematurely after 33 weeks and 3 days of gestation and it was initially thought that the hairless regions, which also had no skin cover, were caused by a fetal scalp electrode. The twins had otherwise developed normally, with no associated anomalies or syndromes, and the defects on their scalps had healed over with scar tissue.

[Articles] An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction

Thu, 05 Sep 2019 23:00:09 +0000

An AI-enabled ECG acquired during normal sinus rhythm permits identification at point of care of individuals with atrial fibrillation.

[Articles] Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

Thu, 05 Sep 2019 23:00:09 +0000

Treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy. Therefore, its routine use for this condition should be reconsidered.

[Articles] Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial

Thu, 05 Sep 2019 23:00:09 +0000

MOABP does not reduce SSIs or the overall morbidity of colon surgery compared with NBP. We therefore propose that the current recommendations of using MOABP for colectomies to reduce SSIs or morbidity should be reconsidered.

[Articles] Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis (ECLIPSE): results from a phase 3, randomised controlled trial

Thu, 05 Sep 2019 23:00:09 +0000

Guselkumab showed superior long-term efficacy based on PASI 90 at week 48 when compared with secukinumab for treating moderate-to-severe psoriasis. This finding could assist health-care providers in their decision making process when selecting a biologic for treating moderate-to-severe psoriasis.

[Department of Error] Department of Error

Thu, 05 Sep 2019 23:00:09 +0000

Danaei G, Harirchi I, Sajadi HS, Yahyaei F, Majdzadeh R. The harsh effects of sanctions on Iranian health. Lancet 2019; 394: 468–69—In this Correspondence, spelling of author Reza Majdzadeh's name was incorrect. This correction has been made to the online version as of August 13, 2019.

[Correspondence] Radiotherapy for metastatic prostate cancer–Authors' reply

Thu, 05 Sep 2019 23:00:09 +0000

We thank Mohamed Alaa Gouda and Ana Aparicio and colleagues for their interest in our study.1

[Correspondence] Health in the UK–Authors’ reply

Thu, 05 Sep 2019 23:00:09 +0000

We thank Peter Simpson and Janet Cade for highlighting that the burden of disease was higher in Scotland than in England in 2016, and that the national results for Scotland do not show subnational inequalities in Scotland. The Global Burden of Disease Study (GBD) includes more subnational estimates each year, but this has not yet been the case for Scotland. The Scottish Burden of Disease study used different methods and found that the fewest age-standardised life-years lost (YLLs) per 100 000 populations were observed in East Renfrewshire (10 107 years) and the highest were in Glasgow city (17 427 years), which was 72% higher than in East Renfrewshire.

[Correspondence] Health in the UK

Thu, 05 Sep 2019 23:00:08 +0000

Polycystic ovary syndrome (PCOS) is one of the most common conditions in women of reproductive age, with a prevalence of 8–13% and important associated metabolic and mental health issues.1 Despite this, PCOS is not mentioned in Nicholas Steel and collegues’ Global Burden of Disease Study (GBD).2 GBD informs policy makers by incorporating the effect, relative harm, and the prevalence of the disease in their report.3 PCOS has such a high prevalence and effect on day-to-day quality of life4 that we feel it should be captured in this data.

[Correspondence] Health in the UK

Thu, 05 Sep 2019 23:00:08 +0000

The comparison of changes in cause-specific life-years lost between England and Scotland during 1990–20161 took some account of the late registration of deaths in England (also in Wales and Northern Ireland). Unlike in Scotland, where fact-of-death is registered within 8 days of death having been ascertained, inquest deaths in the other nations of the UK are not registered until a coroner has determined the cause of death.2 Life tables published by the Office for National Statistics feature age at registration of death, rather than age at death.

[Correspondence] Health in the UK

Thu, 05 Sep 2019 23:00:08 +0000

Is Blackpool really the worst place in the UK in terms of ill health and years of life lost? We doubt it, and suspect that the UK location with the worst health outcomes is Glasgow. However, Blackpool is singled out in the UK analysis of the Global Burden of Disease Study 2016 by Nicholas Steel and colleagues.1 As Ellen Nolte comments,2 this study provides important insights into the patterns of disease burden across the devolved nations of the UK, across English local authorities, and over time.

[Correspondence] Health in the Arab world

Thu, 05 Sep 2019 23:00:08 +0000

Richard Horton1 urges the global health community to tackle the multiple predicaments facing Arab countries. The diversity of Arab countries is matched only by the multitude of challenges they face—from limited basic care for refugees to the overwhelming prevalence of non-communicable diseases in Gulf countries.2 Challenges and disparities in Arab countries necessitate health interventions that are tailored to specific contexts. Health entrepreneurship is essential to the process of translating the achievements of research and development into improving health outcomes both globally and in Arab countries.

[Correspondence] Child marriage in the Arab world

Thu, 05 Sep 2019 23:00:08 +0000

We welcome Richard Horton's Comment,1 in which he highlights the lack of prioritisation of the health needs of a region that has faced tremendous human tragedy over the past several decades. Our ongoing research in Jordan has elucidated a hidden and at-risk population: displaced, married adolescent girls. Our concern for this population has become more urgent since the Jordanian Parliament rejected a measure to eliminate the exceptions under which girls younger than 18 years can be legally married, citing a lack of evidence of the health consequences of child marriage.

[Correspondence] Ebola virus disease and breastfeeding: time for attention

Thu, 05 Sep 2019 23:00:08 +0000

This year's Global Nutrition Cluster meeting in July, 2019, offered a platform on which to discuss all nutrition-related humanitarian emergencies. Ebola virus disease (EVD) and breastfeeding in DR Congo was an obvious topic. More than 2800 cases have been confirmed in the ongoing outbreak in DR Congo; most cases are adults, and 56% of cases are women.1 Ample information is available on the presence of Ebola virus in bodily fluids such as blood, urine, and semen, and on the prevention of transmission from these fluids.

[Perspectives] Eva Kor

Thu, 05 Sep 2019 23:00:08 +0000

Holocaust survivor who advocated forgiveness. She was born on Jan 31, 1934, in Portz, Romania, and died with respiratory disease on July 4, 2019, in Kraków, Poland, aged 85 years.

[Perspectives] Empathy in the age of the electronic medical record

Thu, 05 Sep 2019 23:00:08 +0000

In 1891, the English artist Sir Luke Fildes painted what is considered to be the iconic portrait of a physician. In The Doctor, a Victorian general practitioner in formal black attire is seated at the bedside of a sick child, staring pensively at the young girl. The family huddles in the background, awaiting the doctor's determination.

[Perspectives] Helen Brooke Taussig: preserver of babies’ hearts and limbs

Thu, 05 Sep 2019 23:00:08 +0000

As a paediatric cardiologist in Depression-era America, Helen Brooke Taussig (1898–1986) saw many “blue” babies, their blood starved of oxygen as it failed to circulate properly through the lungs. The infants gasped for breath after the least exertion and usually died at an early age. After studying the condition, which was caused by a cluster of congenital heart defects, Taussig proposed to her surgical colleague at Johns Hopkins University, Alfred Blalock (1899–1964), that it might be alleviated by a procedure to divert another artery to the lungs.

[Perspectives] Winners take all

Thu, 05 Sep 2019 23:00:08 +0000

“It feels like I’m at a firefighters conference and no one's allowed to speak about water…We can talk for a very long time about all these stupid philanthropy schemes…we’ve got to be talking about taxes…Taxes, taxes, taxes. All the rest is bullshit in my opinion.” Thus did Dutch writer and historian Rutger Bregman introduce himself to the World Economic Forum meeting in Davos in January, 2019. Alongside government leaders, billionaire philanthropists were, as Bregman saw it, gathered in self-congratulatory mode.

[World Report] Gavi sets US$7·4 billion replenishment target

Thu, 05 Sep 2019 23:00:08 +0000

In the next 5 years, Gavi aims to vaccinate 300 million children and will have a greater focus on building primary health-care systems. Ann Danaiya Usher reports.

[Comment] Offline: A canon for global health

Thu, 05 Sep 2019 23:00:08 +0000

Research papers have become the tainted currency of academic medicine. With their hyper-stylised and increasingly guideline-driven formats, scientific articles are displays of conformity and submission. They signal acceptance of imposed norms of professional communication that strip imagination, feeling, and passion from scientific exchange. The communication of science is today trapped within conservative structures of dialogue. If you were asked to construct a canon of writing in global health, what would you include? As important as new scientific discoveries are, don't begin with research articles.

[Comment] No-deal food planning in UK Brexit

Thu, 05 Sep 2019 23:00:08 +0000

Even for a country with a long history of arguments about food supply,1 the UK's present situation is remarkable. A country that received 28% of its food in 2018 directly from the European Union (EU),2 plus 11% more through EU trade deals,3 is now planning, under the leadership of Prime Minister Boris Johnson, to leave the EU (“Brexit”) on Oct 31, 2019, with or without an agreement on how and what the terms are for trade, customs, and food security. The food implications for consumers and public health of a no-deal Brexit are seeping out of government but deserve full scrutiny.

[Comment] AI can now identify atrial fibrillation through sinus rhythm

Thu, 05 Sep 2019 23:00:08 +0000

Atrial fibrillation is a substantial health-care challenge and is considered to be a global pandemic, as prevalence rates have increased greatly1 and atrial fibrillation-related hospitalisations outnumber those of major cardiac conditions such as heart failure and myocardial infarction.2 Atrial fibrillation confers an increased risk of stroke and mortality; it therefore needs to be detected not only to manage the arrhythmia but also to prevent comorbidities and death.3 A 10-second, 12-lead electrocardiograph (ECG) in current clinical practice is unlikely to reveal possible atrial fibrillation if not present in this short monitoring time.

[Comment] Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy

Thu, 05 Sep 2019 23:00:08 +0000

Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease, with a global incidence of between 0·2% and 2·0%. Intrahepatic cholestasis of pregnancy is characterised by otherwise unexplained pruritus, typically starting in the late second or third trimester of pregnancy, increased serum bile acid concentration or transaminase concentration, or both, and spontaneous relief of symptoms and normalisation of biochemical abnormalities post partum.1,2 Intrahepatic cholestasis of pregnancy is associated with adverse pregnancy outcomes, including fetal distress, meconium-stained amniotic fluid, spontaneous and iatrogenic preterm birth, neonatal unit admission, and stillbirth.

[Comment] Is preoperative bowel preparation needed before elective colectomy?

Thu, 05 Sep 2019 23:00:08 +0000

Postoperative surgical site infections (SSI) including anastomotic leakage are severe postoperative morbidities. Anastomotic leakage is most common following distal left-sided colorectal anastomosis, which is where most efforts in anastomotic leakage reduction have been focused. Multiple approaches have been employed to mitigate against this problem, including mechanical and oral antibiotic bowel preparation (MOABP). Less attention has been devoted to colectomy followed by ileocolic or colocolic anastomosis.

[Comment] Psoriasis biologics: a new era of choice

Thu, 05 Sep 2019 23:00:08 +0000

Psoriasis is a chronic inflammatory skin condition affecting more than 125 million individuals worldwide.1 It is associated with mortality and multimorbidity. The introduction of a plethora of biologic drugs has transformed patient outcomes such that skin clearance is now a realistic treatment goal. Psoriasis biologic drugs target tumour necrosis factor α (etanercept, infliximab, adalimumab, and certolizumab), the p40 subunit of interleukin (IL)-12 and IL-23 (ustekinumab), IL-17 (secukinumab [IL-17A], ixekizumab [IL-17A], and brodalumab [IL-17RA]), and the p19 subunit of IL-23 (IL-23p19; guselkumab, tildrakizumab, and risankizumab).

[Editorial] Suicide risk in US veterans

Thu, 05 Sep 2019 23:00:08 +0000

An update to the US Department of Veterans Affairs and Department of Defense guidelines for the assessment and management of patients at risk of suicide was published in the Annals of Internal Medicine on Aug 27, 2019, the first update since the creation of the original guidelines in 2013. These expanded guidelines come as the incidence of suicide in the USA grows ever greater.

[Editorial] NICE hypertension guidelines: a pragmatic compromise

Thu, 05 Sep 2019 23:00:07 +0000

The latest UK National Institute for Health and Clinical Excellence (NICE) guidance, published Aug 28, recommends that antihypertensives be offered to people younger than 80 years with stage 1 hypertension—defined as 140/90 mm Hg and above—and a 10% or greater risk of developing cardiovascular disease within the next 10 years, a change from the 2011 NICE guideline of a cardiovascular risk level of 20% or more.

[Editorial] Lawsuits alone will not fix the US opioid overdose crisis

Thu, 05 Sep 2019 23:00:07 +0000

On Aug 26, a judge ruled that Johnson & Johnson—parent company of Janssen Pharmaceuticals—must pay the state of Oklahoma, USA, $572 million for knowingly overstating the benefits and downplaying the dangers of opioids and contributing to the crisis that has claimed the lives of 400 000 Americans over the past two decades. That amount represents only a small fraction of what the state was seeking, estimating that it would need $17 billion over 20 years to adequately address the crisis that has severely affected Oklahoma and other states, especially in the midwest and northeast.

Physicians Under 40 Make About $60K Less Than Older Peers

Thu, 05 Sep 2019 18:13:43 +0000

Young physicians in plastic surgery had the most debt. Time spent on administrative tasks was roughly the same for older and younger physicians.
Medscape Medical News

Imposter Doc Guilty of Prescribing Over 200K Opioid Doses: DOJ

Thu, 05 Sep 2019 18:46:24 +0000

A Houston-area man who posed as a physician was found guilty of conspiring to unlawfully prescribe hundreds of thousands of doses of opioids at a "pill mill."
Medscape Medical News

Polyphor Reinvents Itself After Abandoning Antibiotic Trial

Thu, 05 Sep 2019 16:15:55 +0000

Drugmaker Polyphor is hiring new managers and shifting focus after a trial of its top antibiotic hopeful proved too dangerous to continue, the Swiss company said on Wednesday.
Reuters Health Information

Zimbabwe Proposes Designating Health Services as Essential Amid Doctors' Strike

Thu, 05 Sep 2019 16:21:07 +0000

Zimbabwe's cabinet is proposing designating health services as "essential" to be provided at all times to try to limit strikes by medical personnel as a work stoppage by public sector doctors over pay entered a second day on Wednesday.
Reuters Health Information

Medical Masks, N95 Respirators Provide Similar Protection

Thu, 05 Sep 2019 14:52:10 +0000

Ordinary medical masks protected outpatient healthcare personnel against lab-confirmed influenza as much as more expensive N95 respirators, a study found.
Medscape Medical News

Sublingual Immunotherapy Safe, Effective For Peanut Allergy

Thu, 05 Sep 2019 15:34:56 +0000

Sublingual immunotherapy is easy, effective, and well-tolerated and may provide an alternative to oral immunotherapy and a skin patch, each of which has shortcomings, the authors of a small study suggest.
Medscape Medical News

Top Hungarian Scientist Appeals Against Overhaul of Academic Research

Thu, 05 Sep 2019 13:54:56 +0000

The president of the Hungarian Academy of Sciences (HAS) has appealed to the Constitutional Court to strike down a reform that strips his august institution of its research network, part of government plans to tighten state control over academic life.
Reuters Health Information

Наращивание ресниц чревато серьезными инфекциями век

Thu, 05 Sep 2019 19:09:00 +0000

Наращивание ресниц значительно увеличивает количество серьезных инфекций век, предупреждают специалисты-офтальмологи. Всем, кто прибегает к процедуре наращивания, очень важно заботиться о веках, защищая их от повреждений, а также строго соблюдать правила гигиены.

Ten-Fold Rise in Deaths from Fentanyl, Other Synthetic Opioids

Thu, 05 Sep 2019 10:14:22 +0000

US deaths from synthetic opioids rose more than 10-fold from 2013 to 2018, leading to an epidemic 'unlike others that have struck the nation,' says a new report.
Medscape Medical News

Bayer Hires Former J&J Executive for More Pharma Deals

Thu, 05 Sep 2019 09:08:33 +0000

Bayer said it hired Johnson & Johnson executive Marianne De Backer to manage acquisitions and licensing deals at its drugs unit, as the German drugmaker turns to outside sources to boost its development pipeline.
Reuters Health Information

'Snack Tax' Will Have Much Greater Impact Than Levy on Soft Drinks

Thu, 05 Sep 2019 08:59:23 +0000

Taxing sugary snacks may have a much greater impact on obesity than levies on sweetened drinks, but critics say policies to reduce consumption of "bad" foods still "fail to incentivize" healthy foods.
Medscape Medical News

Орехи полезны для здоровья сердца

Thu, 05 Sep 2019 13:56:17 +0000

Иранские ученые во время 12-летнего наблюдения над участниками исследования установили, что употребление в пищу орехов два и более раз в неделю может снизить риск смерти от сердечно-сосудистых заболеваний на 17% по сравнению с употреблением орехов один раз в две недели.

Stop Prescribing Antipsychotics for Delirium

Thu, 05 Sep 2019 07:26:51 +0000

Evidence does not support long-standing routine use of antipsychotic medications for the prevention or treatment of delirium in hospitalized patients, two systematic reviews found.
Medscape Medical News

Аспирин не следует принимать здоровым людям после 70 лет

Thu, 05 Sep 2019 09:03:17 +0000

Умеренное снижение риска сердечно-сосудистых заболеваний в результате приема аспирина перевешивается повышенной опасностью кровотечений. Об этом свидетельствует доклад австралийских ученых, представленный недавно на конгрессе Европейского общества кардиологов.

Risk Score Reveals Nonvascular Factors Linked To GI Bleed

Thu, 05 Sep 2019 02:45:17 +0000

Identification of nonvascular factors that predict major gastrointestinal bleed may help in choosing the most appropriate patients for primary prevention of cardiovascular disease, say researchers.
Medscape News UK

GYN Oncologists More Likely to Follow Risk-Reducing Salpingo-Oophorectomy Guidelines

Wed, 04 Sep 2019 22:55:14 +0000

Most gynecologic oncologists adhere to surgical guidelines for risk-reducing salpingo-oophorectomy, compared with less than half of other obstetrician-gynecologists, researchers report.
Reuters Health Information

OxyContin Maker Prepares 'Free-Fall' Bankruptcy as Settlement Talks Stall - Sources

Wed, 04 Sep 2019 23:01:29 +0000

OxyContin maker Purdue Pharma LP is preparing to seek bankruptcy protection before the end of the month if it does not reach a settlement with U.S. communities over widespread opioid litigation, three people familiar with the matter said, after some states balked at the company's $10 billion to $12 billion offer in August to end their lawsuits as part of a negotiated Chapter 11 case.
Reuters Health Information

Ablation, Surgery Edge Sclerotherapy for Varicose Veins

Wed, 04 Sep 2019 17:00:37 +0000

In a multicenter randomized trial, outcomes with laser ablation and surgery were better at 5 years post treatment than with foam sclerotherapy; laser treatment was most cost-effective.
Medscape Medical News

Medical Groups, NEJM Editors Urge Abortion Rights Protection

Wed, 04 Sep 2019 17:04:18 +0000

The editors of the New England Journal of Medicine and five obstetrics and gynecology medical groups published a joint editorial today emphatically supporting the protection of abortion rights.
Medscape Medical News

Dirty Work to End the HIV Epidemic

Wed, 04 Sep 2019 16:43:45 +0000

When there is an outbreak of HIV, specialists can't get into social networks fast enough to stop the spread if there is no groundwork laid in the communities most vulnerable to transmission.
Medscape Medical News

Myth Busted? No Sex Differences in Typical MI Symptoms

Wed, 04 Sep 2019 15:17:13 +0000

Typical MI symptoms are more common and have greater predictive value in women than men, and guidelines should be updated to reflect this, researchers say.
Medscape Medical News

Nasal Polyps May Increase Risk of Cancer in the Nasal Cavities

Wed, 04 Sep 2019 14:01:52 +0000

Nasal polyps in patients aged 50 and older appear to increase the risk of certain head and neck cancers, suggests a population-based cohort study.
Medscape Medical News

HiSTORIC Validates High-Sensitivity Troponin Test to Rule Out MI

Wed, 04 Sep 2019 12:57:58 +0000

Clinical practice is already shifting toward an early-rule-out pathway with a single high-sensitivity troponin test, but this is the first randomized controlled trial to support the strategy.
Medscape Medical News

Vintage ICD Trials in Heart Failure Upheld by Contemporary Data

Wed, 04 Sep 2019 13:11:11 +0000

Primary-prevention defibrillators still cut mortality, validating guidelines based on decades-old trials like SCD-HeFT and MADIT-2 conducted before profound improvements in heart failure management.
Medscape Medical News

AAN, AHS Release New Guidelines on Pediatric Migraine

Wed, 04 Sep 2019 13:42:14 +0000

More evidence for using triptans alone or with NSAIDs for acute migraine and using a more holistic approach to prevention are highlights of pediatric guidelines updated for the first time since 2004.
Medscape Medical News

У женатых и замужних ниже риск развития деменции

Wed, 04 Sep 2019 19:08:11 +0000

Состоящие в браке люди с меньшей вероятностью страдают от деменции в пожилом возрасте. А среди разведенных, вдовствующих, никогда не состоявших в браке и сожителей самый высокий риск деменции оказался у разведенных. К такому выводу пришли авторы исследования, проведенного в США.

What Do You Think of Accepting Payments From Drug Companies?

Wed, 04 Sep 2019 11:29:31 +0000

Industry payments to physicians added up to $9.35 billion in 2018, according to CMS' Open Payments website.
Medscape Reader Polls

DAPA: Early ICD After Primary PCI-Treated STEMI Saves Lives

Wed, 04 Sep 2019 09:06:25 +0000

Patients with STEMI who underwent early ICD implantation had a survival benefit 10 years later, compared with standard medical care, although questions remain over patient selection.
Medscape Medical News

Soft Drinks Once Again Associated With Premature Death

Wed, 04 Sep 2019 09:41:03 +0000

Soft drinks, both sugar- and artificially sweetened, linked again to increased mortality in large European study; researchers say this is further evidence supporting public health campaigns to limit intake.
Medscape Medical News

SYNTAXES: CABG for Best 10-Year Survival in Multivessel Disease

Wed, 04 Sep 2019 09:44:20 +0000

Longer-term outcome data from SYNTAX trial give a 'clear mandate' to expand the role of CABG and to adopt a more cautious indication for PCI in multivessel disease, one expert says.
Medscape Medical News

Beyond the Enamel: Oral Health's Connection to Well-being

Wed, 04 Sep 2019 08:16:57 +0000

Medical and dental schools parted ways around the 1920s; however, specialists are renewing common ground to work together on patient care.
Medscape Medical News

Что такое видеокапсульная колоноскопия

Wed, 04 Sep 2019 13:58:21 +0000

Ежегодно колоректальным раком заболевают 47 тысяч россиян. По мнению специалистов, если бы каждый человек старше 45 лет регулярно проходил такое исследование, как колоноскопия, то рак прямой и толстой кишки стал бы редчайшим заболеванием. О возможностях комфортного обследования кишечника рассказала врач-эндоскопист столичной ГКБ №17 Екатерина Тихомирова.

Эпидемию кори в Европе может остановить только вакцинация

Wed, 04 Sep 2019 09:01:17 +0000

Резкий всплеск кори в Европе ставит под угрозу жизни людей: по официальным данным ВОЗ, число случаев заболевания в первой половине 2019 года превысило заболеваемость за весь прошлый год. Единственной защитой от болезни является вакцинация.

US Physicians Increasingly Support the ACA

Tue, 03 Sep 2019 18:56:55 +0000

Physicians' support for the Affordable Care Act has markedly risen since its implementation in 2012, new data show.
Medscape Medical News

New Criteria a "Paradigm Shift" for Systemic Lupus Erythematosus

Tue, 03 Sep 2019 18:37:32 +0000

New classification criteria for systemic lupus erythematosus (SLE) from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) represent a "paradigm shift" in how the disease is diagnosed and studied, the developers say.
Reuters Health Information

Later Onset of Infections After Splenectomy Seen With Vaccination

Tue, 03 Sep 2019 18:42:16 +0000

Vaccination is associated with later onset of infection in adults who undergo splenectomy, according to findings from the Rochester (Minnesota) Epidemiology Project (REP).
Reuters Health Information

DOJ Takes Down 'Pill Mill' Network for Millions of RXs

Tue, 03 Sep 2019 17:54:13 +0000

In less than 15 months, one Houston-area doctor allegedly prescribed about 2 million pills of controlled substances, including over 800,000 oxycodone pills and almost 450,000 hydrocodone pills.
Medscape Medical News

Chest X-Ray Favored for Lung Surveillance After High-Grade Soft Tissue Sarcoma

Tue, 03 Sep 2019 17:43:35 +0000

Chest x-ray may be better than chest CT for lung surveillance after resection of high-grade soft-tissue sarcoma, according to findings from the U.S. Sarcoma Collaborative (USSC).
Reuters Health Information

Tuberculosis Rates Down in Most US Children, but Still High in Some Groups

Tue, 03 Sep 2019 17:33:28 +0000

Over the past decade, the number of children and teens in the U.S diagnosed with tuberculosis has decreased by nearly half, according to a new study.
Reuters Health Information

Disabled Workers Chase 'Dream Jobs' in Tight U.S. Labor Market

Tue, 03 Sep 2019 17:14:56 +0000

Megan Helsel, a kayaking wildlife specialist, has her dream job, and T'angelo Magee is making headway toward his, a commercial pilot. Both say work is central to their identity. Both are disabled.
Reuters Health Information

Microplastics Turning Up in Human Stool

Tue, 03 Sep 2019 17:05:21 +0000

Tiny bits of plastic may be getting into our bodies via the air we breathe and the food we eat, a new study suggests.
Reuters Health Information

Czech Doctors Deliver Baby Girl 117 Days After Mother's Brain-Death

Tue, 03 Sep 2019 16:39:06 +0000

When a helicopter rushed an unconscious Czech woman who had suffered a severe stroke to hospital in April, her chances of survival were slim - and those of the fetus she had carried in her womb for 15 weeks little better.
Reuters Health Information

MITRA-FR at 2 Years: MitraClip Still No Bettter Than Med Therapy

Tue, 03 Sep 2019 14:54:37 +0000

New data show no change in the overall primary end point, but a post hoc analysis leaves room for interpretation and further fodder for what has been a rousing controversy in the mitral valve space over the past year.
Medscape Medical News

More GI Symptoms From Oral Immunotherapy With Higher Baseline Eosinophil Counts

Tue, 03 Sep 2019 14:29:43 +0000

Higher baseline absolute eosinophil counts (AECs) are associated with an increased risk of oral-immunotherapy-induced gastrointestinal symptoms and eosinophilic responses (OITIGER), researchers from Israel report.
Reuters Health Information

Genetic Testing Spots Clopidogrel Responders After PCI for STEMI

Tue, 03 Sep 2019 14:24:57 +0000

Guidelines for the management of acute STEMI patients undergoing PCI may need to be revised after a genotype-guided protocol giving clopidogrel to responders reduced bleeding rates, say experts.
Medscape Medical News

Из-за социального стресса может понизиться плотность костей после менопаузы

Tue, 03 Sep 2019 18:52:14 +0000

Как показало исследование ученых из США, социальная напряженность у пожилых женщин ведет к увеличению потери минеральной плотности костей в шейке бедра и позвоночнике.

Text Messages Improve Blood Glucose Control in Diabetes

Tue, 03 Sep 2019 11:29:29 +0000

Low-cost text messaging program improves glycemic control over usual care in patients with diabetes and coronary heart disease.
Medscape Medical News

Cesarean Delivery Tied to Increased Risk for Autism, ADHD

Tue, 03 Sep 2019 10:16:46 +0000

Although cesarean deliveries have been linked previously with a higher risk for several disorders in offspring, new research also suggests an association with risk for autism and ADHD.
Medscape Medical News

Intense Step Training May Improve Walking, Balance After Stroke

Tue, 03 Sep 2019 09:14:02 +0000

Challenging patients after a stroke with intense and complex tasks that mirror real-world challenges may improve walking skills such as gait symmetry, new research suggests.
Medscape Medical News

Oxygen in Suspected ACS May Benefit Those With Low Levels

Tue, 03 Sep 2019 09:26:15 +0000

A new study involving the whole of New Zealand suggests that oxygen may be beneficial for patients with saturation levels below 95%.
Medscape Medical News

Родительское выгорание: в чем его опасность для детей и родителей

Tue, 03 Sep 2019 14:28:47 +0000

Выгорание родителей является причиной размышлений об уходе из семьи, насилия со стороны родителей и отсутствия родительского внимания. Об этом свидетельствуют данные бельгийско-британских исследований.

Антибиотики могут увеличивать риск развития ревматоидного артрита

Tue, 03 Sep 2019 09:01:58 +0000

Авторы нового британского исследования установили, что ревматоидный артрит развивается у 26 из 100 000 человек, принимавших антибиотики. При этом чем больше антибиотиков принимали пациенты и чем меньше времени проходило со времени лечения, тем больше была вероятность заболеть артритом.

AFIRE Backs Less Antiplatelet Use With NOAC in AF, Stable CAD

Mon, 02 Sep 2019 15:14:09 +0000

Helping buttress a thin evidence base, the randomized trial argues against pairing a novel oral anticoagulant with an antiplatelet in stable CAD with AF, barring PCI or CABG in the last year.
Medscape Medical News

DANAMI-2: PCI Still Beats Lysis in STEMI Even 16 Years On

Mon, 02 Sep 2019 13:55:43 +0000

Physicians 'should feel confident' that offering primary PCI to patients with STEMI in an invasive center will offer long-term benefits over giving fibrinolysis at a local hospital, say Danish researchers.
Medscape Medical News

Community-Wide Salt Swap Moves BP Needle, Halves Hypertension

Mon, 02 Sep 2019 13:23:25 +0000

Salt substitution at the population level has the potential to improve blood pressure control and alarming rates of nonadherence to hypertension drug therapy globally, the authors say.
Medscape Medical News

Оптимизм и наличие цели в жизни — хорошая защита здоровья сердца и сосудов

Mon, 02 Sep 2019 19:07:26 +0000

Склонные к оптимизму люди почти на 40% реже умирают от сердечных заболеваний. А люди, считающие, что они имеют «высокую цель в жизни», значительно меньше подвержены риску инсульта. Это показал обзор исследований разных лет, проведенный сотрудниками Гарварда.

New ESC Guideline on SVT Management: Catheter Ablation Key

Mon, 02 Sep 2019 11:53:39 +0000

The safer use of medications and the compelling evidence for catheter ablation have led to a complete overhaul of the ESC guidelines for the management of supraventricular tachycardia, says an expert.
Medscape Medical News

ESC Diabetes and CVD Guideline: 'Unprecedented' New Evidence

Mon, 02 Sep 2019 12:33:18 +0000

Recent 'huge changes' in diabetes management prompted revision of new practice guidelines, developed by the European Society of Cardiology with the European Association for the Study of Diabetes.
Medscape Medical News

ISAR-REACT 5: Prasugrel Bests Ticagrelor in ACS

Mon, 02 Sep 2019 11:19:42 +0000

In this 'landmark' head-to-head trial, 1-year survival free of MI or stroke was better in patients with ACS who received prasugrel rather than ticagrelor -- contrary to the researchers' hypothesis.
Medscape Medical News

Global Guidelines: Try Testosterone for Older Women's Sex Drive

Mon, 02 Sep 2019 08:33:49 +0000

Evidence indicates benefits for postmenopausal sexual dysfunction but not for menopausal symptoms, including hot flushes, night sweats, anxiety, low mood, or sleep disruptions.
Medscape Medical News

«Увольнение с работы — последний способ защиты врачей. Похоже, других прав у нас не осталось»

Mon, 02 Sep 2019 14:03:48 +0000

Оптимизация здравоохранения добралась до учреждений ФМБА. Из Медсанчасти №72 Трехгорного Челябинской области увольняются все хирурги. Недовольны происходящими изменениями и сотрудники медсанчасти №94 в подмосковном Пересвете. И это всего лишь два примера того, что происходит по всей стране: работа на износ, низкие зарплаты и замалчивание руководством проблем делают свое дело.

HIV: Underlying Infection Still Drives Deaths in US

Mon, 02 Sep 2019 07:02:58 +0000

Life expectancy for US adults infected with HIV has risen dramatically since the early 1980s, but patients are still dying from HIV-related causes rather than age-related conditions.
Medscape Medical News

Обилие растительного белка в рационе положительно влияет на продолжительность жизни

Mon, 02 Sep 2019 09:18:07 +0000

Согласно исследованию, проведенному в Японии, люди, потребляющие больше растительного белка, могут жить дольше, чем те, кто получает больше белка из мяса. Замена всего 3% красного мяса в рационе растительным белком снижает риск смерти от рака на 39% и от болезней сердца на 42%.

Dapagliflozin: New HF Therapy, Even Sans Diabetes

Sun, 01 Sep 2019 16:07:01 +0000

Significant reductions in heart failure events and mortality associated with the diabetes drug in the randomized trial point to a new era in the treatment of heart failure, experts say.
Medscape Medical News

PARAGON-HF: Sacubitril/Valsartan Frustrates in Preserved-EF HF

Sun, 01 Sep 2019 14:33:56 +0000

Hopes were the trial would provide something new: solid clinical trial backing for an HFpEF drug therapy. It didn't, but some say it supports consideration of the drug in at least one HFpEF subgroup.
Medscape Medical News

THEMIS: A Role for Ticagrelor in Diabetic Patients With Prior PCI?

Sun, 01 Sep 2019 13:43:45 +0000

For patients with type 2 diabetes and stable coronary artery disease, ticagrelor had no net clinical benefit in the overall trial, but results in patients with a previous PCI were more promising.
Medscape Medical News

COMPLETE: Better Outcome With PCI in Nonculprit Lesions After STEMI

Sun, 01 Sep 2019 10:51:42 +0000

New data show intervention in nonculprit lesions after STEMI in patients with multivessel disease reduced CV death, recurrent MI, and ischemia-driven revascularization vs a culprit-lesion-only strategy.
Medscape Medical News

Stable CAD Reconsidered: ESC Chronic Coronary Syndrome Guideline

Sun, 01 Sep 2019 09:08:26 +0000

The document sees chronic coronary disease as a dynamic process poorly served by the term 'stable' CAD. It defines CCS by six clinical scenarios with different diagnostic and therapeutic issues.
Medscape Medical News

New European Lipid Guidelines Take Aggressive Approach

Sun, 01 Sep 2019 08:28:06 +0000

New lipid guidelines from the European Society of Cardiology/European Atherosclerosis Society are recommending lower targets for LDL reduction than have been seen before for most risk categories.
Medscape Medical News

Early Evolocumab in Acute Coronary Syndrome Safe, LDL Plummets

Sat, 31 Aug 2019 13:35:04 +0000

EVOPACS, the first randomized trial of a PCSK9 inhibitor in this very high-risk setting, hints earlier use may be warranted, but experts agree that a dedicated CV outcomes trial is needed first.
Medscape Medical News

EHR-Related Malpractice Suits Are on the Rise, but Low Overall

Fri, 30 Aug 2019 19:20:27 +0000

A new analysis of malpractice claims shows increase in EHR issues from 2010 to 2018, although the percentage of all claims still remains low.
Medscape Medical News

Calls Mount to Stop Vaping as Lung Injury Cases Skyrocket

Fri, 30 Aug 2019 18:11:34 +0000

As lung injuries mount across the United States, officials suspect THC-containing e-cigarette products could possibly play a role.
Medscape Medical News

Language Barrier in ED Results in Hodgepodge of Communication Efforts

Fri, 30 Aug 2019 16:23:41 +0000

Emergency department staff in the U.S. use various strategies to communicate with patients with limited English proficiency, often multiple approaches with a single patient, and the communication strategy typically varies across successive phases of care, according to a new study.
Reuters Health Information

Asymptomatic Bacteriuria Often Inappropriately Treated With Antibiotics

Fri, 30 Aug 2019 15:24:05 +0000

Hospitalized patients with asymptomatic bacteriuria (ASB) are often inappropriately given antibiotics, which is unlikely to improve outcomes and may prolong hospital stay, new research suggests.
Reuters Health Information

Trans Men Require Comprehensive Contraception Counseling

Fri, 30 Aug 2019 15:33:01 +0000

Transmasculine individuals require comprehensive, gender-affirming contraception counseling, and more research is needed to provide optimal recommendations, researchers say.
Reuters Health Information

FTC Probes Marketing Practices of E-Cigarette Maker Juul - Source

Fri, 30 Aug 2019 13:27:16 +0000

The Federal Trade Commission is investigating the marketing practices of e-cigarette maker Juul Labs Inc sending shares of tobacco stocks down, a person briefed on the matter said Thursday.
Reuters Health Information

Uganda Confirms Another Ebola Case

Fri, 30 Aug 2019 13:27:27 +0000

Uganda reported another case of Ebola on Thursday, a nine-year-old girl who had crossed the border from neighboring Democratic Republic of Congo, where the haemorrhagic disease has killed at least 1,800 in a year-long outbreak.
Reuters Health Information

Democrats' Medicare for All Plans Must Consider Union-Negotiated Health Plans - AFL-CIO Chief

Fri, 30 Aug 2019 13:10:43 +0000

Democratic White House hopefuls should ensure their Medicare for All proposals honor union-negotiated private insurance, AFL-CIO President Richard Trumka, head of the largest federation of U.S. labor unions, said on Thursday.
Reuters Health Information

'Social Jet Lag' Linked to Poorly Controlled Diabetes

Fri, 30 Aug 2019 13:10:31 +0000

Diabetics with irregular sleep schedules that diverge from their internal body clocks may be at increased risk for high blood sugar, a small study suggests.
Reuters Health Information

Ученые доказали пользу красного вина

Fri, 30 Aug 2019 19:17:24 +0000

Кишечный микробиом любителей красного вина более разнообразен по сравнению с кишечной микрофлорой любителей других спиртных напитков, как выяснили британские исследователи. Умеренное потребление красного вина снижает риск ожирения.

Older Women Have More Complications From Mastectomy With Immediate Breast Reconstruction

Fri, 30 Aug 2019 12:27:17 +0000

Postoperative-complication rates after mastectomy with immediate breast reconstruction are higher for women aged 65 years and older than for younger women, according to a database study.
Reuters Health Information

Therapy for Insomnia Improves CPAP Use, Acceptance

Fri, 30 Aug 2019 12:45:50 +0000

Cognitive behavioral therapy (CBT) improves use of continuous positive airway pressure (CPAP) in patients with comorbid insomnia and obstructive sleep apnea (OSA), according to a new randomized controlled trial.
Reuters Health Information

Patients Die on Wait List as US Centers Refuse Donor Kidneys

Fri, 30 Aug 2019 11:54:18 +0000

Opportunities are missed to transplant kidneys into waiting dialysis patients as centers turn down multiple offers for willing candidates because organs proffered are perceived to be "less than perfect."
Medscape Medical News

More U.S. Teens Exposed to Secondhand E-Cigarette Vapor

Fri, 30 Aug 2019 11:04:04 +0000

Exposure to secondhand chemicals emitted from e-cigarettes is on the rise among middle- and high-school students, a new study suggests.
Reuters Health Information

U.S. to Pay for Thousands of Doses of HIV Drugs for Venezuelan Migrants

Fri, 30 Aug 2019 11:31:34 +0000

The United States said on Wednesday it will provide thousands of doses of HIV medication to treat Venezuelans in Colombia as part of regional efforts to manage care for millions of migrants fleeing the crisis-hit nation.
Reuters Health Information

No Single 'Gay Gene': New Data

Fri, 30 Aug 2019 11:01:16 +0000

Genetic variants can't meaningfully predict same-sex sexual behavior; rather, a combination of small genetic factors and environment likely influence partner choice, a large study shows.
Medscape Medical News

Twins, Triplets Have Higher Risk of Medical Mix-Ups in Neonatal ICUs

Fri, 30 Aug 2019 10:46:25 +0000

Doctors are much more likely to make mistakes ordering medicines or treatments for babies in the ICU when these infants are twins or triplets than when they are they singletons, a U.S. study suggests.
Reuters Health Information

VA/DoD Update of Suicide Prevention Guidelines

Fri, 30 Aug 2019 09:20:48 +0000

Treatment recommendations for suicide prevention, based on a new systematic review, include cognitive-behavioral therapy, short-term ketamine infusions, and lithium.
Medscape Medical News

Незаконные требования оплаты и другие нарушения прав пациентов в системе ОМС

Fri, 30 Aug 2019 14:01:15 +0000

Всероссийский союз страховщиков продолжает знакомить граждан с новыми правами и возможностями пациентов. Что система ОМС предлагает сегодня пациентам? В каких случаях чаще всего нарушаются права пациентов? Как страховые медорганизации и пациентские организации защищают права пациентов? Почему пациенты должны знать о своих правах и уметь ими пользоваться?

Гены играют существенную роль при развитии деменции

Fri, 30 Aug 2019 08:56:58 +0000

Пожилым людям для предотвращения деменции следует хорошо питаться, вести активный образ жизни и не курить. Однако при наличии генетической предрасположенности к заболеваниям, ухудшающим память, здоровый образ жизни не влияет на утрату когнитивных способностей.

U.S. FDA Says Widening Probe on Generic Drug Impurities

Thu, 29 Aug 2019 21:39:13 +0000

The U.S. Food and Drug Administration said on Wednesday it was expanding its investigation into impurities in U.S. generic drugs beyond a class of medicines for high blood pressure known as angiotensin II receptor blockers (ARBs).
Reuters Health Information

[Seminar] Alcohol use disorders

Thu, 29 Aug 2019 23:00:09 +0000

Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent mental disorders globally, especially in high-income and upper-middle-income countries; and are associated with high mortality and burden of disease, mainly due to medical consequences, such as liver cirrhosis or injury. Despite their high prevalence, alcohol use disorders are undertreated partly because of the high stigma associated with them, but also because of insufficient systematic screening in primary health care, although effective and cost-effective psychosocial and pharmacological interventions do exist.

[Clinical Picture] Salty water stymies shock from an implantable defibrillator?

Thu, 29 Aug 2019 23:00:09 +0000

A 17-year-old competitive athlete was seen in our cardiology department 2 days after he experienced palpitations, dizziness, and syncope while swimming in a pool of salty-tasting water in Mallorca, Spain. He explained that after the palpitations he felt his subcutaneous implantable cardioverter defibrillator (S-ICD) deliver a shock. He then started swimming towards the side of the pool, but began to feel faint and passed out. After a few seconds, he regained consciousness and got out of the water.

[Articles] Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study

Thu, 29 Aug 2019 23:00:09 +0000

In our study, a small set of pathogens accounted for most cases of pneumonia requiring hospital admission. Preventing and treating a subset of pathogens could substantially affect childhood pneumonia outcomes.

[Articles] The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial

Thu, 29 Aug 2019 23:00:09 +0000

Both TKR and PKR are effective, offer similar clinical outcomes, and result in a similar incidence of re-operations and complications. Based on our clinical findings, and results regarding the lower costs and better cost-effectiveness with PKR during the 5-year study period, we suggest that PKR should be considered the first choice for patients with late-stage isolated medial compartment osteoarthritis.

[Articles] Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial

Thu, 29 Aug 2019 23:00:09 +0000

In the acute treatment of migraine, a single 75 mg dose of rimegepant in an orally disintegrating tablet formulation was more effective than placebo. Tolerability was similar to placebo, with no safety concerns.

[Correspondence] Knee and hip replacements and the risk of revision – Authors' reply

Thu, 29 Aug 2019 23:00:09 +0000

We thank Edward Burn and colleagues, Michael Tanzer, and Ze-Yu Luo and colleagues for their comments on our Articles.1,2

[Correspondence] Knee and hip replacements and the risk of revision

Thu, 29 Aug 2019 23:00:09 +0000

As Jonathan Evans and colleagues1 report, survivorship of total hip replacement was 85·7% (95% CI 85·0–86·5) at 15 years, 78·8% (77·8–79·9) at 20 years, and 77·6% (76·0–79·2) at 25 years in the case series, and 89·4% (89·2–89·6) at 15 years, 70·2% (69·7–70·7) at 20 years, and 57·9% (57·1–58·7) at 25 years derived from registry data. The data answered a question asked by nearly all patients who come to our outpatient department for total hip replacement.

[Correspondence] Knee and hip replacements and the risk of revision

Thu, 29 Aug 2019 23:00:09 +0000

Jonathan Evans and colleagues1 conclude that one can expect a hip replacement to last 25 years in around 58% of patients. Although this finding is based on registry data, the implants used 25 years ago are not the same as the ones used today. More importantly, the polyethylene with which the femoral component articulates has changed dramatically, which has resulted in a substantial improvement in implant longevity. The polyethylene used today is called highly cross-linked polyethylene and has been commercially available for approximately 20 years.

[Correspondence] Knee and hip replacements and the risk of revision

Thu, 29 Aug 2019 23:00:09 +0000

We read with interest the Articles by Jonathan Evans and colleagues1,2 on implant survival after knee and hip replacements. Based on an exhaustive literature review and meta-analysis, the authors found long-term implant survival to be better than was generally thought.

[Department of Error] Department of Error

Thu, 29 Aug 2019 23:00:08 +0000

The Pneumonia Etiology Research for Child Health (PERCH) Study Group. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet 2019; 394: 757–79—In this Article, the list of contributors to the study design was incorrect. David R Murdoch contributed to designing the study, not David P Moore. This correction has been made to the online version as of Aug 29, 2019, and the printed version is correct.

[Correspondence] Deep medicine, artificial intelligence, and the practising clinician

Thu, 29 Aug 2019 23:00:08 +0000

Indra Joshi's brilliant Perspective1 offers an in-depth analysis of Eric Topol's book, Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. However, several essential concerns about artificial intelligence (AI) in the clinic were not, or not sufficiently, addressed.

[Correspondence] RTS,S malaria vaccine could provide major public health benefits

Thu, 29 Aug 2019 23:00:08 +0000

In a World Report, Paul Adjepou1 highlighted that World Malaria Day 2019 was marked by a major step forward: the start of the large-scale pilot implementation of the world's first malaria vaccine, RTS,S/AS01 (Mosquirix; GlaxoSmithKline, Belgium), in Malawi. Despite the substantial progress in the fight against this disease in the past decade, one death due to malaria still occurs every 2 min, and 2017 data2 suggest that the decline in mortality is slowing. Other tools that could help reach the public health goals of malaria control should therefore be welcomed.

[Correspondence] Marketing of legalised cannabis: a concern about poisoning

Thu, 29 Aug 2019 23:00:08 +0000

As a result of cannabis liberalisation in North America, legal cannabis-based industries are developing and a new generation of δ-9-tetrahydrocannabinol (THC)-containing products are emerging. Novel and attractive designs are now available, such as cannabis sweets and recreational vape pens with flavoured and highly concentrated cannabis oil cartridges. Therefore, cannabis legalisation is not only allowing recreative or therapeutic users to legally use cannabis; it also opens up opportunities for the cannabis industry to attract new customers.

[Correspondence] The UK National Health Service regulations for overseas visitors

Thu, 29 Aug 2019 23:00:08 +0000

Medical leaders are speaking out against the amended UK National Health Service (NHS) charging regulations for overseas visitors. In March, 2019, the Academy of Medical Royal Colleges released a statement about the public health consequences of these regulations, which were amended in October, 2017, highlighting the broad consensus across the country's medical leadership, of both the direct and indirect adverse health effects of the policy.1 The statement also endorses the recommendations of the UCL-Lancet Commission on Migration and Health by Ibrahim Abubakar and colleagues,2 which called for universal and equitable access to health services for all and a commitment from policy makers towards a humane approach to migrant health.

[Correspondence] The unbearable lightness of the dominant narrative on Cuba

Thu, 29 Aug 2019 23:00:08 +0000

The Editors1 rightly acknowledged that the former WHO Director-General “called on the world to model their health systems on Cuba's” given its “commitment to its people's health”, yet the seemingly neutral tone of the Editorial conceals a problematic agenda with implications for health justice.

[Correspondence] US restrictions jeopardise health of Americans and Cubans

Thu, 29 Aug 2019 23:00:08 +0000

While the Editorial1 on health rights in the new Cuban constitution was in press, President Trump initiated another move to scuttle the Cuban economy. So, as Cuban citizens voted to expand constitutional rights on Feb 24, 2019, he exerted more pressure on already embargoed Cuba, endangering the potential to fully exercise those rights.2

[Correspondence] UK alcohol policy: the Brexit effect

Thu, 29 Aug 2019 23:00:08 +0000

We were very interested to read Ian Gilmore and Roger Williams' Comment.1 Between 2017 and 2019, we have been researching alcohol policy (along with other health areas) for a project funded by the Economic and Social Research Council about health law outside the EU, and the immediate, intermediate, and long-term impacts.

[Correspondence] Compensating for a shortage of corneal donors after Brexit

Thu, 29 Aug 2019 23:00:08 +0000

Corneal transplantation is one of the most common and successful transplant procedures worldwide.1 Although it is predominantly done to improve or preserve sight, the procedure can also be done to preserve the eye or for pain relief to improve a patient's quality of life.

[Correspondence] UN high-level meeting: time to act on universal health coverage

Thu, 29 Aug 2019 23:00:08 +0000

We are restless for change. UHC2030 is a multi-stakeholder platform that aims to strengthen the global movement for universal health coverage (UHC), and we are calling for urgent action. As stakeholders from governments, civil society, the private sector, development partners, academia, and the media, we are pushing for all countries to implement UHC as fast as possible.

[Correspondence] Medical schools should ensure and improve global health education

Thu, 29 Aug 2019 23:00:08 +0000

As global health educators and researchers from the Netherlands, we read the assessment by Amelia Seifalian and colleagues1 of the status of global health education in the UK with interest and recognition. Although nearly all of the universities in the Netherlands offer global health-themed education activities, such as global health courses and clinical and scientific internships abroad (including training before the overseas internship and peer coaching sessions while abroad),2 we believe the value of this education is often underappreciated.

[Perspectives] Picturing health: health services in refugee camps are helping South Sudanese women tell their stories of sexual violence

Thu, 29 Aug 2019 23:00:08 +0000

The Médecins Sans Frontières (MSF) sexual violence and mental health clinic in the Omugo settlement in the Rhino camp extension looks similar to the other refugee camp structures in northern Uganda, which are home to hundreds of thousands of South Sudanese refugees. Since the war in South Sudan erupted in 2013, a steady flow of people, including many women and children, have made the harrowing trek from their homes and across the border into Uganda.

[World Report] Sexual violence, HIV, and conflict in South Sudan

Thu, 29 Aug 2019 23:00:08 +0000

As refugees flee conflict in South Sudan, the burden of HIV grows, in part because of rampant sexual violence. Amanda Sperber reports from Yumbe.

[World Report] The darker side of paradise: heroin addiction in Zanzibar

Thu, 29 Aug 2019 23:00:08 +0000

Behind the beautiful touristic sand beaches, sober recovery houses provide safe havens for the thousands of people dealing with heroin addiction in Zanzibar. Amy Yee reports from Stone Town.

[Comment] Nicotine without smoke: fighting the tobacco epidemic with harm reduction

Thu, 29 Aug 2019 23:00:08 +0000

The rapid rise of smoke-free nicotine products, especially vaping, is the most disruptive influence on smoking in decades. These products are challenging not only smoked tobacco's stranglehold on the nicotine market but also the public health response to tobacco harm reduction, including by WHO.1 In October, 2018, 72 experts with no connections to the tobacco industry wrote to the WHO Director-General to argue that WHO should embrace innovation and more actively include tobacco harm reduction in its strategy to tackle the burden of smoking-related disease.

[Comment] Trade, nutrition, and sustainable food systems

Thu, 29 Aug 2019 23:00:08 +0000

The 2019 Lancet Commission on the global syndemic of obesity, undernutrition, and climate change and the EAT–Lancet Commission on healthy diets from sustainable food systems identified trade as an important consideration in improving nutrition and the sustainability of food systems.1,2 Both of these Commissions point to the need for public health actors to engage more strategically with national and international trade policy processes to mitigate harms and maximise benefits for food systems and nutrition.

[Comment] What the PERCH study means for future pneumonia strategies

Thu, 29 Aug 2019 23:00:08 +0000

Identifying the causes of acute lower respiratory infections is challenging in most clinical settings, especially so in hospitals in low-income and middle-income countries where bacteriology and other diagnostic services are scarce. The diseases encompassed within WHO's clinical definition of pneumonia include bacterial and viral pneumonia, acute viral bronchiolitis, and bacterial and viral bronchitis. These conditions can coexist and duel pathogens are common, especially in severely unwell children in low-resource settings.

[Comment] Partial versus total knee replacement for knee osteoarthritis

Thu, 29 Aug 2019 23:00:08 +0000

Triangulation of findings from several different study designs is important in the generation of the best broadly applicable and generalisable evidence to guide the delivery of efficacious and cost-effective health-care interventions. David Beard and colleagues1 report in The Lancet an impressive randomised controlled trial that compared the outcomes of partial knee replacement (PKR) and total knee replacement (TKR) for treatment of isolated medial compartment osteoarthritis of the knee in 528 patients (42% female, mean age 65·0 years) who had an American Society of Anesthesiologists score of 1 or 2, an intact anterior cruciate ligament, and correctable varus deformity.

[Comment] Rimegepant oral disintegrating tablet for migraine

Thu, 29 Aug 2019 23:00:07 +0000

In The Lancet, Robert Croop and colleagues1 present a carefully designed phase 3 trial on an oral disintegrating tablet (ODT) of rimegepant for the acute treatment of migraine among 1375 patients (85% female, mean age 40·2 years [SD 12·0]). The trial was positive, showing an increase in relief from headache pain among the group receiving rimegepant at 2 h after dosing (10% over placebo) and improvement in the most bothersome symptoms, which included photophobia and nausea (8% over placebo). The onset was reported to be slightly faster than that of other gepants (first positive effect at 1 h for rimegepant vs 2 h for telcagepant) and the effect on the lower side (10% for rimegepant vs a mean of 17% in four trials on telcagepant), but the duration was up to 48 h.

[Editorial] Managing conflicts of interests in clinical guidelines

Thu, 29 Aug 2019 23:00:07 +0000

Conflicts of interests (COIs) are pervasive in medicine, and their influence on clinical guidelines crucial to patient care has been a major concern worldwide. Only 26% of Chinese clinical practice guidelines published in 2017 disclosed COIs. By contrast, Ramy Saleh and colleagues found that 44 (85%) of 52 first and last authors of clinical practice guidelines for systemic therapy published on the American Society of Clinical Oncology's website between August, 2013, and June, 2018, received payments from industry, whereas 14 (32%) did not disclose such payments.

[Editorial] Caring for survivors of institutional child abuse

Thu, 29 Aug 2019 23:00:07 +0000

Institutional child abuse is particularly noxious in its betrayal of trust. On Aug 21, an Australian court dismissed an appeal against the conviction of child sexual abuse by Cardinal George Pell, once the third most senior Catholic cleric. However, the Catholic Church is not the only culpable institution. Australia's Royal Commission into Institutional Responses to Child Sexual Abuse (the final report was published in 2017) uncovered atrocities in residential, educational, religious, recreational, sports, and health-care institutions.

[Editorial] Philip Morris International: money over morality?

Thu, 29 Aug 2019 23:00:07 +0000

In the ongoing UnSmoke Your World campaign, Philip Morris International (PMI) calls for never-smokers to stay away from cigarettes, for smokers to quit, and for those smokers who do not quit to change to better alternatives. The development of those better alternatives, PMI suggests, is incumbent upon them and fulfils its commitment to help move the world towards a smoke-free future. PMI is now navigating consumers away from cigarettes and towards its own e-cigarettes and heat-not-burn products.

Surgeon General Warns of Marijuana Risk in Pregnancy, Youth

Thu, 29 Aug 2019 18:10:10 +0000

The top US physician said there's increased public acceptance of the drug at a time when it's being sold in more potent forms than in the past. "This ain't your mother's marijuana," Jerome Adams said.
Medscape Medical News

U.S. Republican Senator Isakson Resigning for Medical Reasons

Thu, 29 Aug 2019 17:23:23 +0000

Republican U.S. Senator Johnny Isakson of Georgia said on Wednesday he will leave the Senate at the end of 2019, citing his struggles with Parkinson's disease and other medical issues.
Reuters Health Information

Methotrexate-Biologics Combo Provides Better Outcomes in Early Rheumatoid Arthritis

Thu, 29 Aug 2019 17:13:48 +0000

The combination of methotrexate with TNF inhibitors or non-TNF biologics provides better outcomes than methotrexate monotherapy in adults with early rheumatoid arthritis (RA), according to a new systematic review and network meta-analysis.
Reuters Health Information

FDA Urges Transition to Disposable Duodenoscopes

Thu, 29 Aug 2019 17:23:09 +0000

The FDA wants to move away from using duodenoscopes with fixed endcaps to those with disposable components or to fully disposable duodenoscopes when they become available.
News Alerts

Tandem Autologous Stem-Cell Transplant Boosts Event-Free Neuroblastoma Survival

Thu, 29 Aug 2019 16:32:06 +0000

Tandem autologous stem-cell transplant (ASCT) may provide better event-free survival (EFS) in patients with high-risk neuroblastoma, compared with single ASCT, a new clinical trial shows.
Reuters Health Information

Cost-Effectiveness of Implant for Sleep Apnea Uncertain

Thu, 29 Aug 2019 16:31:57 +0000

The Inspire II Upper Airway Stimulator, an implanted hypoglossal nerve stimulator (HGNS) for treatment of obstructive sleep apnea, works well in many, but fails to help a substantial proportion of patients, and others may require further surgery, according to new findings.
Reuters Health Information

U.S. Judge Rules for Sanofi in Amgen Patent Fight

Thu, 29 Aug 2019 16:24:17 +0000

A U.S. judge on Wednesday set aside a jury verdict that Amgen Inc patents on its cholesterol medication Repatha were valid, handing a victory to Regeneron Pharmaceuticals Inc and Sanofi SA, which make a rival drug.
Reuters Health Information

Tumor Seeding During Colonoscopy Linked to Metachronous Colorectal Cancer

Thu, 29 Aug 2019 16:23:54 +0000

Tumor seeding may occur during colonoscopy, although the risk is low, a proof-of-principle study reveals.
Reuters Health Information

Larger Plus Smaller Infarctions Linked to Accelerated Cognitive Decline

Thu, 29 Aug 2019 16:10:08 +0000

The combination of larger and smaller subclinical infarctions in middle age may accelerate the risk for cognitive decline later in life, researchers say.
Reuters Health Information

Share Tips for Potential Story Ideas

Thu, 29 Aug 2019 15:56:13 +0000

Do you have a tip about a potential story we should investigate? Here’s how to get in touch with us.
Medscape Medical News

Global Measles Cases Three Times Higher Than Last Year - WHO

Thu, 29 Aug 2019 15:50:09 +0000

Every region in the world, except the Americas, is experiencing an increase in the number of cases of measles, a vaccine-preventable disease that can kill or disable children, the World Health Organization (WHO) said on Thursday.
Reuters Health Information

Mumps Cases Reported in Migrant Detention Centers

Thu, 29 Aug 2019 14:00:52 +0000

Mumps outbreaks continue in multiple migrant detention facilities in the United States, the CDC reports.
Medscape Medical News

Expert Panel Algorithm for Post-TAVR Conduction Disturbances

Thu, 29 Aug 2019 14:16:55 +0000

TAVR carries a risk for postprocedure conduction disturbances. This first-time algorithm stratifies patients and recommends strategies for assessing and managing these arrhythmias.
Medscape Medical News

Few Mental Health, Violence Interventions for LGBTQ Youth

Thu, 29 Aug 2019 14:46:55 +0000

Sexual/gender minority youth experience greater mental health problems, substance abuse, and violence victimization, but a new review shows there are few evidence-based inclusive interventions.
Medscape Medical News

Еда перед сном не вредна для женщин, если только она белковая

Thu, 29 Aug 2019 19:06:41 +0000

Многие уверены в том, что еда на ночь способствует набору веса и замедляет метаболизм. Новое исследование американских авторов показывает, что это справедливо, только если съедать много калорийной пищи, богатой жирами и углеводами. А вот употребление белка приносит пользу.

Optimal Dual Antiplatelet Duration After Minor Stroke or TIA?

Thu, 29 Aug 2019 12:01:16 +0000

Pooled data from two large trials points to a net benefit associated with 21 days of clopidogrel–aspirin therapy after a minor stroke or transient ischemic attack.
Medscape Medical News

Physician Incomes Up in 2018, but Productivity Stagnant: AMGA

Thu, 29 Aug 2019 06:07:14 +0000

A 2019 medical group compensation and productivity survey also shows hefty increases for primary care specialties as value-based care gains traction.
Medscape Medical News

High-Dose Drug Combo Excels in Osteoporosis, but Cost a Barrier

Thu, 29 Aug 2019 10:00:15 +0000

The combination of high-dose teriparatide with denosumab could represent an ideal intervention for postmenopausal women with osteoporosis at very high risk of fracture; cost is a concern, however.
Medscape Medical News

New AAN Guideline Backs Routine Vaccinations in MS

Thu, 29 Aug 2019 09:42:06 +0000

Preventing infections in patients with multiple sclerosis through routine immunizations is a key part of medical care, an updated practice guideline states.
Medscape Medical News

Serious Liver Injury Tied to HCV Drugs in Rare Cases, FDA Warns

Thu, 29 Aug 2019 08:24:17 +0000

The US Food and Drug Agency has warned that three direct-acting antiviral drugs have been associated with rare cases of severe liver injury in patients being treated for hepatitis C virus infection.
News Alerts

Самый рискованный период для хирургических больных не в операционной

Thu, 29 Aug 2019 13:56:15 +0000

Новое исследование показало, что большинство пациентов хирургических отделений умирает не на операционном столе, а во время послеоперационного восстановления в больнице или дома. Основные причины смерти — это осложнения, связанные с сильным кровотечением, нарушением работы сердца и инфекцией кровотока.

Physician Incomes Up in 2018, but Productivity Stagnant: AMGA

Thu, 29 Aug 2019 06:07:14 +0000

A 2019 medical group compensation and productivity survey also shows hefty increases for primary care specialties as value-based care gains traction.

Болевые ощущения у женщин во время секса — табуированная тема

Thu, 29 Aug 2019 09:17:22 +0000

Как отмечают эксперты, боль во время секса испытывают многие женщины. Эта проблема не должна замалчиваться. Необходимы серьезные исследования, открытые обсуждения в СМИ и доступная медицинская и психологическая помощь.

Higher-Dose Vitamin D in Healthy Adults May Harm Bone Health

Wed, 28 Aug 2019 23:22:25 +0000

Higher doses of vitamin D in healthy adults who aren't vitamin D deficient do not improve bone health and may actually be harmful, according to a randomized controlled trial.
Reuters Health Information

Pureed Peanuts Advised for Infants to Stave Off Allergy

Wed, 28 Aug 2019 23:30:31 +0000

Feeding pureed peanut products regularly to babies before their first birthday could reduce their risk of developing peanut allergies later on, doctors advise.
Reuters Health Information

Seeking Trial Enrollment, Oncologist Alienates Patient

Wed, 28 Aug 2019 17:00:00 +0000

An oncologist tries to enroll a patient in a clinical trial with a seemingly tricky informed consent — and the patient's daughter explains how that touched an old hurt.
Medscape Medical News

Decades-Long Drop in Cardiovascular Deaths Slowing Down

Wed, 28 Aug 2019 14:59:53 +0000

Deaths from cardiometabolic causes continue to drop over time but are starting to plateau, a "concerning" development for the future, new research suggests.
Medscape Medical News

Public Health Officials Warn About Eastern Equine Encephalitis

Wed, 28 Aug 2019 13:57:59 +0000

Medical officials are warning residents about the rare but deadly eastern equine encephalitis virus, a mosquito-borne virus that can cause brain swelling and leads to death in about 30% of cases.
WebMD Health News

Amazon Rainforest Fires: Effects on Health, Weather

Wed, 28 Aug 2019 14:12:07 +0000

The Amazon rainforest fires that have been blazing out of control in Brazil for weeks could have far-reaching effects on our health, experts warn.
WebMD Health News

Hormone Therapy Doesn't Prevent Age-Related Muscle Loss in Women

Wed, 28 Aug 2019 14:12:54 +0000

Postmenopausal women taking hormone therapy to compensate for estrogen decline did not lose less muscle than women not taking hormone supplements, a systematic review and meta-analysis found.
Medscape Medical News

EC Clears Eculizumab (Soliris) for Neuromyelitis Optica

Wed, 28 Aug 2019 14:38:41 +0000

Eculizumab is now indicated in Europe for adults with neuromyelitis optica spectrum disorder who are anti-aquaporin-4 (AQP4) antibody-positive and whose disease is following a relapsing course.
International Approvals

Purdue Pharma in Discussion on $10 Bln-$12 Bln Offer to Settle Opioid Lawsuits - Sources

Wed, 28 Aug 2019 13:05:13 +0000

OxyContin maker Purdue Pharma LP and its owners, the Sackler family, are in discussion to settle more than 2,000 opioid lawsuits against the company for $10 billion to $12 billion, two people familiar with the matter said on Tuesday.
Reuters Health Information

Рыбий жир не предотвращает сахарный диабет 2-го типа

Wed, 28 Aug 2019 19:18:27 +0000

Систематический обзор рандомизированных контролируемых исследований, проведенный по заказу ВОЗ, показал, что добавки с длинноцепочечными омега-3-полиненасыщенными жирными кислотами (рыбьим жиром) практически не оказывают влияния на риск развития диабета 2-го типа.

FDA Okays Biobeat's Cuffless Blood Pressure Monitor

Wed, 28 Aug 2019 12:39:40 +0000

The approval, which includes a smartwatch and single-use wearable patch, is the first FDA approval of a blood pressure monitor that doesn't use a traditional cuff.
Medscape Medical News

Modern Tech Sheds Light on Hypoglycemia in Absence of Diabetes

Wed, 28 Aug 2019 11:20:45 +0000

Whether true "hypoglycemia" occurs in people without diabetes has been controversial for decades, but modern technology may shed light, according to a new study considered "a starting point."
Medscape Medical News

Guidelines May Speed Obesity Hypoventilation Syndrome Diagnosis

Wed, 28 Aug 2019 10:07:32 +0000

With the condition considered "vastly undiagnosed," recommendations include simplified screening, optimal treatment options.
Medscape Medical News

Altered Visual Processing a Nonverbal Marker of Autism?

Wed, 28 Aug 2019 10:19:35 +0000

Atypical visual processing detected via electroencephalography may be a nonverbal neural marker of autism.
Medscape Medical News

NFL Concussions Linked to Low Testosterone, Erectile Dysfunction

Wed, 28 Aug 2019 10:43:42 +0000

Researchers make a strong play that multiple concussions in former football players are associated with a greater likelihood of lower testosterone levels and erectile dysfunction later in life.
Medscape Medical News

Hypertension in Midlife Linked to Brain Pathology in Seniors

Wed, 28 Aug 2019 09:13:26 +0000

Even small increases in blood pressure during an individual's 30s and 40s are associated with white matter hyperintensities and lower brain volume in later life, new research suggests.
Medscape Medical News

Do You Care About Hospital Rankings?

Wed, 28 Aug 2019 09:32:03 +0000

Researchers have critiqued the methodologies of popular hospital rankings as "likely to misclassify hospital performance."
Medscape Reader Polls

Информация о здоровом образе жизни сама по себе не изменяет вредных пищевых привычек детей

Wed, 28 Aug 2019 13:49:41 +0000

Обучение правильному питанию и здоровому образу жизни должно включать теорию, игровую деятельность и эмоциональную поддержку, по данным бразильского исследования, которые будут представлены на конгрессе Европейского общества кардиологии и Всемирном конгрессе кардиологов.

Работа по дому может отсрочить смерть

Wed, 28 Aug 2019 09:13:04 +0000

Даже легкая ежедневная физическая активность существенно снижает риск преждевременной смерти. При возрастании активности до умеренной для долголетия достаточно заниматься 24 минуты в день. Умеренная активность подразумевает быструю ходьбу или просто уборку дома. Это доказало британо-норвежское исследование.

Customers Can Make Fast-Food Combo Meals Healthier

Wed, 28 Aug 2019 01:12:38 +0000

Combination meals in U.S. fast food and fast casual restaurants have lots of calories, saturated fat, sugar and sodium, but customers can make the meals healthier by substituting drinks and toppings, researchers say.
Reuters Health Information

Surgical Residents Harbor Unwarranted Assumptions About DNI/DNR Patients

Wed, 28 Aug 2019 01:12:51 +0000

Many surgical residents assume that patients with a do-not-resuscitate (DNR) or do-not-intubate (DNI) order may prefer less-aggressive care overall, according to new findings.
Reuters Health Information

Fezolinetant Promising for Menopausal Vasomotor Symptoms

Wed, 28 Aug 2019 01:28:28 +0000

Fezolinetant, a neurokinin 3 receptor (NK3R) antagonist, reduced moderate-to-severe vasomotor symptoms (VMS) in menopausal women and was well tolerated, a phase 2 study showed.
Reuters Health Information

Coagulopathy Due to Synthetic Cannabinoids Laced With Rodenticides: Case Report

Wed, 28 Aug 2019 01:28:39 +0000

Coagulopathy in a young woman who smoked synthetic cannabinoids laced with rodenticides was treated successfully in an Illinois clinic during a 2018 outbreak of coagulopathy that spread to several states.
Reuters Health Information

Mixed Outcomes After Liver Resection for NAFLD-Associated Cancer

Wed, 28 Aug 2019 01:40:24 +0000

Liver resection for nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is associated with favorable long-term survival but with more surgical morbidity and post-hepatectomy liver failure, compared with non-NAFLD HCC, researchers from Singapore report.
Reuters Health Information

Most Long-Term Acute Care Hospital Patients Die Within Five Years

Wed, 28 Aug 2019 01:41:00 +0000

Most elderly patients admitted to long-term acute care hospitals die within 5 years, and spend two-thirds of their remaining life as an inpatient, a U.S. study suggests.
Reuters Health Information

Does the US Unnecessarily Discard Donor Kidneys?

Tue, 27 Aug 2019 20:05:36 +0000

According to a recent study, many of the deceased-donor kidneys discarded in the United States would be safely transplanted in France.
Medscape Medical News

FDA OKs Istradefylline for Parkinson's Disease 'Off' Episodes

Tue, 27 Aug 2019 18:42:43 +0000

Oral istradefylline (Nourianz) reduces "off" episodes when added to levodopa/carbidopa in patients with Parkinson's disease.
FDA Approvals

Mysterious Vaping Lung Injuries May Have Flown Under Regulatory Radar

Tue, 27 Aug 2019 16:43:32 +0000

Doctors who saw patients with a mysterious lung illness in the past suspected vaping as the cause but didn't know where to report such cases.
Kaiser Health News

Pharma Cash Rolls Into Congress to Defend an Embattled Industry

Tue, 27 Aug 2019 15:21:59 +0000

Lobbying heats up well ahead of the 2020 elections, led by the Pharmaceutical Research and Manufacturers of America. Lowering drug prices is one cause that unites Republicans and Democrats.
Kaiser Health News

Federal Judge Blocks Restrictive Missouri Abortion Law

Tue, 27 Aug 2019 15:20:20 +0000

A federal judge on Tuesday blocked Missouri from enforcing a law banning abortion in the state after eight weeks except in cases of medical emergency.
Reuters Health Information

Plant Protein in Diet Tied to Lower All-Cause Mortality

Tue, 27 Aug 2019 14:03:04 +0000

Eating plant protein was tied to lower risk for all-cause death, a study found, and an expert stresses a healthy diet, portion control, and exercise.
Medscape Medical News

Высокоинтенсивная ходьба эффективно восстанавливает мобильность после инсульта

Tue, 27 Aug 2019 19:16:44 +0000

Интенсивная ходьба с выполнением разных упражнений (хождением по неровным и наклонным поверхностям, лестницам, препятствиям и гимнастическому бревну) дает лучший реабилитационный эффект у перенесших инсульт, чем медленная ходьба только вперед. Это доказало исследование американских ученых.

Social Media Use Linked 'Indirectly' to Mental Health Harms

Tue, 27 Aug 2019 10:59:16 +0000

As kids are spending more time using social media, new research suggests an adverse impact on mental health, especially in girls, mediated by poorer sleep, less exercise, and cyberbullying.
Medscape Medical News

USPSTF Recommends All Adults Receive HCV Screening

Tue, 27 Aug 2019 11:00:00 +0000

The US Preventive Services Task Force has recommended that essentially all adults receive HCV screening, a major change from past risk-based recommendations.
Medscape Medical News

Alternate-Day Fasting in Short Term Safe, Has Metabolic Benefits

Tue, 27 Aug 2019 11:00:17 +0000

Alternate-day fasting was safe in the short term and led to positive changes in metabolic and cardiovascular biomarkers.
Medscape Medical News

Merck Canada Says New Drug Price Regulations Are Unconstitutional

Tue, 27 Aug 2019 09:56:35 +0000

Merck Canada and a group of pharmaceutical companies are challenging the constitutionality of new regulations meant to lower patented drug prices, the company said in a statement on Friday, in a late bid to derail reforms that would hurt pharmaceutical companies' earnings.
Reuters Health Information

Parents Can Do Better to Keep Their Pot Away From Children

Tue, 27 Aug 2019 09:57:14 +0000

As legal cannabis use becomes increasingly common in the U.S., most parents say they keep their pot out of children's reach, but fewer keep it locked away, a study in Colorado suggests.
Reuters Health Information

ODYSSEY Outcomes: High-risk Patients Benefit More From PCSK9s

Tue, 27 Aug 2019 10:16:04 +0000

Two ODYSSEY Outcomes subgroup analyses shed light on the benefits of PCSK9 inhibition in patients with polyvascular disease and previous CABG.
Medscape Medical News

Periodic Limb Movements of Sleep Tied to Ventricular Tachycardia

Tue, 27 Aug 2019 08:56:16 +0000

Periodic limb movements in sleep with arousals are known to increase the risk for atrial fibrillation, but new research suggests they are also linked to increased risk for nonsustained ventricular tachycardia.
Medscape Medical News

After a 'Living Memorial,' an Oncologist Spreads the Word

Tue, 27 Aug 2019 09:28:45 +0000

Tatiana Prowell, MD, has attended many memorial services. But none before the death of the patient — until this summer. Now, she asks: Why wait until a loved one dies to celebrate them?
Medscape Medical News

«Новые требования понравились не всем клиникам пластической хирургии. Но пришлось меняться»

Tue, 27 Aug 2019 14:11:17 +0000

Прошел год со вступления в силу Порядка оказания медицинской помощи по профилю «пластическая хирургия», установившего новые требования к клиникам пластической хирургии. Каковы плюсы и минусы нового порядка, что меняется в отрасли и как это отражается на пациентах, рассказала главный внештатный пластический хирург Минздрава, д.м.н. Наталья Мантурова.

Нехватка витамина D в детстве может вызвать психологические проблемы в подростковом возрасте

Tue, 27 Aug 2019 09:12:07 +0000

Дефицит витамина D в детстве может вызвать агрессивное поведение, тревожные и депрессивные настроения в подростковом возрасте. Подобная зависимость существует и в отношении белка, транспортирующего витамин. Американские ученые проследили связь между нехваткой витамина и белка с негативным поведением в ходе многолетнего исследования.

New Algorithm Can Help Predict Sudden-Death Risk in Kids With Hypertrophic Cardiomyopathy

Tue, 27 Aug 2019 01:20:34 +0000

Researchers have developed a new model to predict the individualized risk of sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy.
Reuters Health Information

Ebola Appears Contained in Goma, but Flares in Other Parts of Congo - WHO

Tue, 27 Aug 2019 01:27:10 +0000

Ebola appears to be under control in the city of Goma in Congo but it has flared in other parts of the country, where aid workers are combating insecurity and disinformation on social media, the World Health Organization (WHO) said on Friday.
Reuters Health Information

Menopause With Diabetes Tied to More Severe Sleep Problems

Tue, 27 Aug 2019 01:47:37 +0000

Women with type 2 diabetes may face more sleep issues and more severe sleep troubles during menopause than peers without diabetes, a small study suggests.
Reuters Health Information

VA Facilities Offering Cochlear Implants to Vets Are Few and Far Between

Tue, 27 Aug 2019 01:42:07 +0000

Even though American veterans are at high risk for the type of hearing loss that may be improved with cochlear implants, many of them live hours from a VA facility that provides cochlear implant services, a U.S. study suggests.
Reuters Health Information

$572 Million Judgment in Landmark Oklahoma Opioid Lawsuit

Mon, 26 Aug 2019 18:07:54 +0000

The judge in the Oklahoma opioid lawsuit ruled that opioid marketing by Johnson & Johnson and its subsidiary Janssen "created a nuisance" that compromised the health of thousands in the state.
Medscape Medical News

FDA OKs Ixekizumab (Taltz) for Active Ankylosing Spondylitis

Mon, 26 Aug 2019 16:47:42 +0000

The interleukin-17A inhibitor is now indicated for the treatment of adults with active ankylosing spondylitis, as well as for certain patients with plaque psoriasis and active psoriatic arthritis.
FDA Approvals

Прием антибиотиков связан с повышенной вероятностью возникновения рака толстой кишки

Mon, 26 Aug 2019 18:59:34 +0000

Риск развития рака толстой и прямой кишок в некоторой степени зависит от типа и класса назначаемых антибиотиков, как установили авторы исследования, проведенного в Великобритании. Хотя ученые не доказали, что лекарства являются причиной возникновения опухолей, их выводы подтверждают важность разумного назначения антибиотиков.

Topline ORION-11: Inclisiran Scores on All End Points

Mon, 26 Aug 2019 12:48:16 +0000

Two additional phase 3 trials of the investigational, small interfering (si)RNA therapy are due later this year, with regulatory applications in the United States and Europe expected to follow.
Medscape Medical News

Paris, Clinical Trials Très Chic, New Guidelines: ESC Congress '19

Mon, 26 Aug 2019 11:06:21 +0000

At its new venue in the ever-bright City of Lights, the meeting is set to shake up practice with a raft of new guidelines and insights from THEMIS, PARAGON-HF, DAPA-HF, and other major trials.
Medscape Medical News

В столице пройдет Фестиваль скандинавской ходьбы проекта «Московское долголетие»

Mon, 26 Aug 2019 13:24:04 +0000

31 августа в спорткомплексе «Лужники» выйдут на старт 3,5 тысячи участников проекта «Московское долголетие». Ожидается, что это будут самые массовые соревнования среди любителей скандинавской ходьбы старшего возраста. Помимо состязаний для гостей Фестиваля организаторы подготовили концерт с участием известных артистов, интерактивные игры, мастер-классы и лекции о здоровом образ

ABIM Embraces 'Self-Paced' Longitudinal Assessment for MOC

Mon, 26 Aug 2019 06:25:30 +0000

However, the internal medicine board keeps the 10-year maintenance of certification exam for doctors who prefer it. Not everyone is pleased with the new option.
Medscape Medical News

Высокое артериальное давление после 30 лет повышает риск деменции в старости

Mon, 26 Aug 2019 09:02:33 +0000

Новое исследование показало, что в возрасте от 36 до 53 лет наступает «чувствительный период», когда повышенное артериальное давление особенно вредно для мозга. Со временем повышенное давление может привести к ухудшению работы мозга, например, к нарушениям мышления и поведения. Поэтому следует задуматься над тем, чтобы начинать лечить повышенное давление после 30 лет.

Migrants Traveling Through Mexico to the U.S. Face High Violence Risk

Sat, 24 Aug 2019 21:01:10 +0000

Nearly one third of migrants traveling through Mexico to the U.S. experience physical, psychological and/or sexual violence during their journey, a new study finds.
Reuters Health Information

Bismuth Curbs Antibiotic Use for Diarrhea in Pakistan

Sat, 24 Aug 2019 20:57:27 +0000

Encouraging bismuth subsalicylate (BSS) use as a first-line treatment for acute diarrhea and promoting its use for self-management can reduce antibiotic use in Pakistan and other countries around the world, researchers suggest.
Reuters Health Information

Hospitals Treat Patients Without Admitting Them, to Avoid Penalties

Sat, 24 Aug 2019 20:48:21 +0000

Hospitals appear to be treating Medicare patients in emergency departments (EDs) and observation areas to avoid readmissions and the financial penalties associated with them, according to a new U.S. study.
Reuters Health Information

U.S. Medicare Readies New Plan-Shopping Website, but Timing Prompts Concerns

Sat, 24 Aug 2019 12:48:12 +0000

Medicare experts often advise enrollees to re-shop their plan coverage during the annual fall open enrollment period. This is the time when you can make unlimited changes to your prescription drug or Medicare Advantage coverage, and shopping the market can help you save money and make sure you get a best-fit plan.
Reuters Health Information

India Proposes Ban on E-Cigarettes, With Jail Terms for Offenders - Govt Documents

Sat, 24 Aug 2019 12:48:29 +0000

India's health ministry has proposed a ban on the production and import of electronic cigarettes, documents seen by Reuters showed, potentially jeopardizing the expansion plans of big firms like Juul Labs and Philip Morris International.
Reuters Health Information

U.S. Imposes Sanctions on Three Chinese Accused of Fentanyl Trafficking

Sat, 24 Aug 2019 11:16:47 +0000

The U.S. Treasury on Wednesday imposed sanctions on three Chinese men accused of illegally trafficking fentanyl, acting three weeks after President Donald Trump accused Beijing of reneging on pledges to stem a flood of the highly addictive synthetic opioid into the United States.
Reuters Health Information

Trump Administration to Appeal Ruling Blocking Price Disclosure for Drug Ads

Sat, 24 Aug 2019 11:23:40 +0000

The Trump administration is appealing a court ruling that struck down its plan to compel pharmaceutical companies to disclose wholesale prices of their drugs in televisions advertisements.
Reuters Health Information

Fewer Health Care-Associated Infections With All Private Rooms

Sat, 24 Aug 2019 11:29:31 +0000

The move from an older, tertiary-care hospital with ward-type rooms to a completely new facility with all private rooms was associated with decreases in the rates of health care-associated infections and colonization, researchers from Canada report.
Reuters Health Information

GERD a Risk Factor for Temporomandibular Joint Disorders

Sat, 24 Aug 2019 11:28:58 +0000

Gastroesophageal reflux disease (GERD) is associated with a nearly three-fold increased risk of temporomandibular disorders (TMD), according to a new case-control study.
Reuters Health Information

Fewer U.S. Teens Participating in Substance Abuse Prevention Programs

Sat, 24 Aug 2019 11:23:50 +0000

Fewer U.S. adolescents are participating in programs designed to prevent substance abuse, a study suggests.
Reuters Health Information

Aspirin, Mortality Link in Breast Cancer May Depend on Methylation of Breast-Cancer Genes

Sat, 24 Aug 2019 11:35:48 +0000

Prior to diagnosis, breast cancer-related genes appear to interact with aspirin in certain women and could influence survival, an observational study hints.
Reuters Health Information

Psychiatric Illness Tied to Mortality in Patients With ESRD

Fri, 23 Aug 2019 19:36:08 +0000

Hospitalizations with psychiatric illnesses are common in children and adults with end-stage renal disease and are linked to greater risk for early death in adults.
Medscape Medical News

Rating the Raters: Hospital Rating Systems Get Low Grades

Fri, 23 Aug 2019 18:37:26 +0000

Most hospital quality rating systems receive 'Cs' and 'Ds,' except for US News & World Reports' ratings, which achieved a 'B' grade in a new analysis.
Medscape Medical News

Phase 2 Studies Find Rivaroxaban Safe for Pediatric VTE

Fri, 23 Aug 2019 17:02:41 +0000

Body weight-adjusted rivaroxaban is safe for treating children with venous thromboembolism (VTE), according to the results of three new phase 2 studies.
Reuters Health Information

PAs Fight for Right to Follow Patients Into Hospice

Fri, 23 Aug 2019 17:06:59 +0000

Thousands of physician assistants in oncology, primary care, and geriatrics would like to follow their patients into hospice without losing the right to assess needs and prescribe.
Medscape Medical News

'Alarming' First Vaping Death Reported in US

Fri, 23 Aug 2019 17:11:52 +0000

An Illinois resident who had recently vaped and was hospitalized with severe respiratory illness has died.
News Alerts

Dr Donald Lindberg, Pioneer in Medical Informatics, Dies at 85

Fri, 23 Aug 2019 17:32:28 +0000

The trailblazer in the application of computer technology to biomedical research and health information, and former director of the National Library of Medicine, has died.
Medscape Medical News

LAA Electrical Isolation Sparks Strokes, But Is Risk Manageable?

Fri, 23 Aug 2019 15:01:02 +0000

Electrical left atrial appendage isolation allows a small subset of atrial fibrillation patients to discontinue oral anticoagulation, but relies on med compliance for the remainder.
Medscape Medical News

Older Cancer Patients at Higher Risk of C diff Infection

Fri, 23 Aug 2019 15:06:39 +0000

Older hospitalized patients with liquid or metastatic solid tumors were at elevated risk of Clostridiodes difficile infection.
Medscape Medical News

AHA Advisory Backs Prescription Omega-3s for Triglycerides

Fri, 23 Aug 2019 15:37:25 +0000

Prescription-strength omega-3 fatty acids are an effective and safe option for reducing triglycerides, either alone or with other lipid-lowering agents, the AHA says.
Medscape Medical News

Close Relatives of Celiac Disease Patients at Higher Risk

Fri, 23 Aug 2019 13:11:47 +0000

First-degree relatives of patients with celiac disease, even those without symptoms, were at elevated risk, suggesting the value of screening.
Medscape Medical News

Бессонница повышает риск сердечно-сосудистых заболеваний

Fri, 23 Aug 2019 19:03:34 +0000

Ученые обнаружили, что у людей, генетически предрасположенных к бессоннице, выше вероятность возникновения сердечной недостаточности, инсульта и ишемической болезни сердца.

Olanzapine After Psychotic Depression Remission Cuts Relapses

Fri, 23 Aug 2019 11:50:53 +0000

Although patients in remission from psychotic depression can benefit from continuation of an antipsychotic, they may pay for it in weight gain, new research suggests.
Medscape Medical News

Pediatric Death Higher in EDs with Lower Pediatric Readiness

Fri, 23 Aug 2019 12:13:06 +0000

Critically ill children who present to emergency departments with lower pediatric readiness have a greater risk for death, a study found.
Medscape Medical News

New York Sues EPA Over GE's Hudson River PCB Cleanup

Fri, 23 Aug 2019 09:37:10 +0000

New York sued the U.S. Environmental Protection Agency on Wednesday, accusing the agency of prematurely allowing General Electric Co to stop clearing the Hudson River of PCB contamination before the cleanup was finished.
Reuters Health Information

HHS to Provide $23 Mln to Merck for Ebola Vaccine Production

Fri, 23 Aug 2019 09:30:35 +0000

The U.S. Department of Health and Human Services (HHS) said on Wednesday it will fund the manufacturing of Merck & Co Inc's investigational Ebola vaccine called V920, in response to the outbreak of the deadly virus in the Democratic Republic of the Congo (DRC).
Reuters Health Information

Дети делают нас счастливее, но только когда они живут отдельно

Fri, 23 Aug 2019 14:20:53 +0000

Пожилые родители взрослых детей более удовлетворены собственной жизнью и имеют меньше симптомов депрессии, чем их бездетные ровесники, но лишь в том случае, если их «птенцы вылетели из гнезда», согласно новому исследованию немецких ученых.

Физическая активность в течение всей жизни снижает риск колоректальной аденомы

Fri, 23 Aug 2019 09:16:37 +0000

Если более 60 минут в день ежедневно выполнять упражнения средней интенсивности в течение жизни, риск развития прогрессирующих аденоматозных полипов (предшественников колоректального рака) снижается на 39%. Это выяснили бразильские и американские ученые в ходе совместного исследования.

Spain Issues International Alert as Listeriosis Cases Hit 150

Thu, 22 Aug 2019 23:53:40 +0000

Spain's health ministry issued an international alert over the country's biggest ever listeriosis outbreak on Wednesday as the number of people affected rose to 150, including one fatality.
Reuters Health Information

Reticular Pseudodrusen a Risk for More Rapid AMD Progression

Fri, 23 Aug 2019 00:33:42 +0000

Patients with reticular pseudodrusen (RPD)-associated age-related macular degeneration (AMD) are at increased risk of progression to geographic atrophy, researchers say
Reuters Health Information

E-Cigarette Firms Probed Over Health Concerns by U.S. House Panel

Thu, 22 Aug 2019 23:58:21 +0000

Four dominant e-cigarette manufacturers face a probe into the health impacts of their products, as the U.S. House Energy and Commerce Committee asked on Wednesday about the firms' research and marketing practices.
Reuters Health Information

Fully Retrievable Valve Shows Promise for TAVR

Fri, 23 Aug 2019 00:18:33 +0000

The fully retrievable HLT Meridian valve appears safe and effective for transcatheter aortic-valve replacement (TAVR), according to results from the multicenter RADIANT trial.
Reuters Health Information

Marijuana May Undermine Fertility Treatment Success

Fri, 23 Aug 2019 00:01:28 +0000

Women undergoing fertility treatment who smoke marijuana may have more success if they quit, recent research suggests.
Reuters Health Information

Osteoporosis Drugs Don't Reduce Overall Mortality

Thu, 22 Aug 2019 23:34:08 +0000

Antifracture medications do not reduce overall mortality in older patients with osteoporosis, according to an updated systematic review and meta-analysis.
Reuters Health Information

Racial and Ethnic Groups Poorly Represented in Landmark Oncology Trials

Thu, 22 Aug 2019 23:46:58 +0000

Some minorities are underrepresented in trials supporting U.S. Food and Drug Administration (FDA) oncology-drug approvals, according to new research.
Reuters Health Information

New Opioid Drug Appears to Offer Longer-Term Relief From Chronic Pain

Thu, 22 Aug 2019 21:32:09 +0000

The novel mu-opioid-receptor agonist NKTR-181 appears to provides long-term pain relief in patients with chronic low-back pain (CLBP), according to results from the uncontrolled, open-label SUMMIT-08 LTS study.
Reuters Health Information

Child Migrants to Be Held in Detention Longer Under New Trump Administration Rule

Thu, 22 Aug 2019 19:26:31 +0000

The Trump administration on Wednesday unveiled new rules that would allow officials to detain migrant families indefinitely while judges consider whether to grant them asylum in the United States.
Reuters Health Information

Pregnancy After Bariatric Surgery Linked to Adverse Perinatal Outcomes

Thu, 22 Aug 2019 19:29:22 +0000

Pregnancy after bariatric surgery is associated with increases in some adverse perinatal outcomes, according to a new systematic review and meta-analysis.
Reuters Health Information

[Series] Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options

Thu, 22 Aug 2019 23:00:09 +0000

Atherosclerosis and its clinical manifestation as ischaemic heart disease remains a considerable health burden. Given that many factors contribute to ischaemic heart disease, a multifactorial approach to prevention is recommended, starting with lifestyle advice, smoking cessation, and control of known cardiovascular risk factors, such as blood pressure and lipids. Within the lipid profile, the principal target is lowering LDL cholesterol, firstly with lifestyle interventions and subsequently with pharmacological therapy.

[Series] Primary prevention of ischaemic heart disease: populations, individuals, and health professionals

Thu, 22 Aug 2019 23:00:09 +0000

Ischaemic heart disease has a multifactorial aetiology and can be prevented from developing in populations primordially, and in individuals at high risk by primary prevention. The primordial approach focuses on social determinants of health in populations: political, economic, and social factors, principally unplanned urbanisation, illiteracy, poverty, and working and living conditions. Implementation of the UN Sustainable Development Goals can lead to major improvements in cardiovascular health, and adequate health-care financing and universal health care are important for achieving these goals.

[Clinical Picture] Electric shocks and weakness of the right hand in a young man: Hirayama disease

Thu, 22 Aug 2019 23:00:09 +0000

A 25-year-old man presented to our department with a 5-year history of an insidious, progressive weakness in his right hand. Despite being right-handed, he had recently become reliant on his left hand to carry out tasks needing manual dexterity. Clinical examination showed muscular atrophy without fasciculations of the first dorsal interosseous muscle and weakness of both the thenar and hypothenar muscles of the right hand; he also had atrophy but no fasciculation of the lumbrical and interosseous muscles.

[Articles] Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial

Thu, 22 Aug 2019 23:00:09 +0000

Use of polypill was effective in preventing major cardiovascular events. Medication adherence was high and adverse event numbers were low. The polypill strategy could be considered as an additional effective component in controlling cardiovascular diseases, especially in LMICs.

[Articles] Eligibility and subsequent burden of cardiovascular disease of four strategies for blood pressure-lowering treatment: a retrospective cohort study

Thu, 22 Aug 2019 23:00:09 +0000

A cardiovascular risk-based strategy (QRISK2 ≥10%) could prevent over a third more cardiovascular disease events than the 2011 NICE guideline and a fifth more than the 2019 NICE guideline, with similar efficiency regarding number treated per event avoided.

[Articles] The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults

Thu, 22 Aug 2019 23:00:08 +0000

Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process in each of the 44 countries in our study. We also identified countries in each world region that perform better than expected from their economic development, which can direct policy makers to important policy lessons. Given the high disease burden caused by hypertension in LMICs, nationally representative hypertension care cascades, as constructed in this study, are an important measure of progress towards achieving universal health coverage.

[Articles] Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys

Thu, 22 Aug 2019 23:00:08 +0000

Hypertension awareness, treatment, and control have improved substantially in high-income countries since the 1980s and 1990s. However, control rates have plateaued in the past decade, at levels lower than those in high-quality hypertension programmes. There is substantial variation across countries in the rates of hypertension awareness, treatment, and control.

[Correspondence] Patient–doctor engagement in cardiovascular prevention – Authors' reply

Thu, 22 Aug 2019 23:00:08 +0000

We thank Panagiota Anyfanti and colleagues for comments on the VIPVIZA trial.1 We agree that patient–doctor mutual engagement and communication is crucial for improved prevention and is a prerequisite for drug treatment, and preferably for all aspects of prevention.

[Correspondence] Patient–doctor engagement in cardiovascular prevention

Thu, 22 Aug 2019 23:00:08 +0000

We are grateful to Ulf Näslund and colleagues1 for addressing the effect of visualisation of asymptomatic atherosclerosis for cardiovascular prevention. The study showed improvement in cardiovascular risk scores at follow-up in the intervention group, which was attributed to the pictorial presentation of silent carotid atherosclerosis. However, we believe that some other aspects need to be underscored as potential contributors to these outcomes.

[Correspondence] Blood pressure reduction and intravenous thrombolysis – Authors' reply

Thu, 22 Aug 2019 23:00:08 +0000

In light of the neutral findings of two major clinical trials—the international ENCHANTED study1 of increased intensive blood pressure reduction in patients receiving intravenous thrombolysis for acute ischaemic stroke, and the UK-based RIGHT-2 study2 of prehospital, ambulance-administered nitrate patch for patients with suspected acute stroke—Nyika Kruyt and colleagues appropriately highlight some ongoing uncertainty over the best approach to blood pressure control before intravenous thrombolysis and hope that their ongoing registry study (TRUTH)3 will shed further light on this topic.

[Correspondence] Blood pressure reduction and intravenous thrombolysis

Thu, 22 Aug 2019 23:00:08 +0000

In ischaemic stroke a high blood pressure (>140 mm Hg) is well known to be associated with poor outcome, caused, at least partly, by an increased risk of haemorrhagic transformation of the cerebral infarct, particularly in patients who have been treated with intravenous thrombolysis. Therefore, guidelines recommend intravenous thrombolysis in patients with increased blood pressure only after active reduction of blood pressure below 185/110 mm Hg in patients who are otherwise eligible for intravenous thrombolysis.

[Correspondence] Surgery for intracerebral haemorrhage – Authors' reply

Thu, 22 Aug 2019 23:00:08 +0000

We are pleased to answer questions concerning the interpretation of results from the MISTIE III trial.1

[Correspondence] Surgery for intracerebral haemorrhage

Thu, 22 Aug 2019 23:00:08 +0000

We congratulate Daniel F Hanley and the MISTIE III investigators1 for completing their phase 3 randomised controlled trial that assessed the effectiveness of a novel, minimally invasive surgical intervention for intracerebral haemorrhage.1 Surgical learning curves are important, especially in the case of novel interventions.2

[Correspondence] Surgery for intracerebral haemorrhage

Thu, 22 Aug 2019 23:00:08 +0000

The MISTIE III study by Daniel F Hanley and colleagues1 did not show a long-term benefit of minimally invasive surgery with thrombolysis in the management of patients with deep or lobar spontaneous intracerebral haematoma of more than 30 mL.

[Department of Error] Department of Error

Thu, 22 Aug 2019 23:00:08 +0000

McCann ME, de Graaff JC, Dorris L, et al. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet 2019; 393: 664–77—The copyright line of this Article has been updated to reflect that the paper is now Gold Open Access. This correction has been made to the online version as of August 22, 2019.

[Correspondence] Fixed-dose combination antihypertensive medications

Thu, 22 Aug 2019 23:00:08 +0000

On July 9, 2019, WHO added fixed-dose combination antihypertensive medications to the WHO Essential Medicines List. Treatment with fixed-dose combination medicines, also known as single-pill combinations, is the emerging best practice for safe, effective, rapid, and convenient hypertension control. But for these essential medicines to improve care and save lives, countries and health systems must ensure that everyone who needs treatment for hypertension can access them.

[Correspondence] Management of rheumatic mitral stenosis

Thu, 22 Aug 2019 23:00:08 +0000

Mariam Chekhchar and colleagues1 discuss branch retinal artery occlusion in a young woman, probably due to occult cardioembolus from rheumatic mitral stenosis. Despite decreasing incidence in developed nations, rheumatic heart disease remains a major source of preventable morbidity and mortality worldwide2 and we commend the authors for bringing attention to this important clinical entity. However, given this valvulopathy's highly thrombogenic nature, therapeutic anticoagulation should be considered.

[Correspondence] Management of rheumatic mitral stenosis

Thu, 22 Aug 2019 23:00:08 +0000

We read with interest the Lancet Clinical Picture by Mariam Chekhchar and colleagues.1 The authors describe a history of recurrent tonsillitis, suggestive of possible rheumatic heart disease—the most common cause of acquired mitral stenosis.2

[Correspondence] Trial re-investment to build better research for better impact

Thu, 22 Aug 2019 23:00:08 +0000

Clinical trials play a pivotal role in improving patient outcomes and are a crucial factor in the National Institute of Clinical Excellence's assessment of novel therapies.1 From 2016–17 670 000 people were recruited into over 4700 trials across the National Health Service (NHS),2 thanks to more than £200 million of annual investment in the National Institute for Health Research's (NIHR) Clinical Research Network.3 UK cancer trials are developed by the National Cancer Research Institute (NCRI) and delivered by the NIHR.

[Correspondence] The importance of randomised vs non-randomised trials – Authors' reply

Thu, 22 Aug 2019 23:00:08 +0000

We thank the correspondents for their responses to our Comment.1

[Correspondence] The importance of randomised vs non-randomised trials

Thu, 22 Aug 2019 23:00:08 +0000

Hertzel Gerstein and colleagues1 propose that estimates of treatment effects with a relative risk (RR) of more than 4 might show that randomised controlled trials (RCTs) are not needed because confounders are less likely to obscure the true treatment effects when effect sizes are this large. Other studies have suggested different thresholds of an RR of 10 or higher,2 or 5 or higher (or RR <0·2)3 to avoid an RCT. We agree that larger effects are less likely to be explained by confounding factors, but regulatory agencies appear to have no explicit or implicit thresholds for approval without requiring further testing in RCTs.

[Correspondence] The importance of randomised vs non-randomised trials

Thu, 22 Aug 2019 23:00:07 +0000

We thank Hertzel Gerstein and colleagues1 for reminding us of the importance of randomised controlled trials (RCTs). However, RCTs require uncertainty about the benefits of an intervention, and once an intervention has already become health policy, ethical issues with doing an RCT arise.

[Correspondence] High-quality evidence to inform clinical practice

Thu, 22 Aug 2019 23:00:07 +0000

One of the basic tenets of evidence-based medicine is that randomisation is crucial to understanding treatment effects. Observational studies are subject to confounding and selection bias. Researchers can adjust for measured differences between treatment groups, but unmeasured or unmeasurable differences might exist between groups that obscure true treatment effects and cannot be accounted for by any statistical method.1 The published medical literature is filled with examples of associations between treatment and outcome identified in observational studies that were subsequently disproven by well conducted randomised controlled trials (RCTs).

[Obituary] Marc Mitchell

Thu, 22 Aug 2019 23:00:07 +0000

Paediatrician who used digital technologies to improve global health. Born on Sept 1, 1948, in Newton, MA, USA, he died while hiking in Alaska, USA, on June 25, 2019, aged 70 years.

[Perspectives] The soul in medicine

Thu, 22 Aug 2019 23:00:07 +0000

“Things have a life of their own…It's simply a matter of waking up their souls.”Gabriel García Márquez, One Hundred Years of Solitude

[Perspectives] Biological psychiatry's decline and fall

Thu, 22 Aug 2019 23:00:07 +0000

As the 20th century drew to a close, there was an air of optimism among psychiatrists. Long gone were the days when mental disorder and distress were attributed to childhood trauma or “refrigerator mothers” to be treated—if the patient could afford it—by psychoanalysis. Rather, they were manifestations of a biological disease, a malfunctioning of brain processes, either genetically or developmentally caused. The psychiatrists' bible was the monumental US Diagnostic and Statistical Manual of Mental Disorders (DSM) or WHO's equivalent, the International Classification of Diseases.

[Perspectives] Paula Rego: personal and political

Thu, 22 Aug 2019 23:00:07 +0000

Political dictatorship, racism, slavery, abortion, and gender-based violence are all themes that feature in Paula Rego: Obedience and Defiance. This remarkable retrospective of Rego's work, ranging from the 1960s to the 21st century, at MK Gallery in Milton Keynes, UK, showcases what the curator, Catherine Lampert, describes as the “moral challenges to humanity, particularly in the face of violence, gender discrimination and political tyranny”. Rego grew up under Portuguese dictator António de Oliveira Salazar and attended the UK's Slade School of Art in the 1950s, where she met painter Victor Willing who became her husband.

[World Report] Palliative care in Tajikistan

Thu, 22 Aug 2019 23:00:07 +0000

Provision of palliative care in Tajikistan is growing rapidly, after being non-existent just 15 years ago, despite political sensitivities over opioids for medical use. Jacqui Thornton reports.

[Comment] Non-communicable diseases and climate change: linked global emergencies

Thu, 22 Aug 2019 23:00:07 +0000

In the annual University College London–Lancet Global Health Lecture in April, 2019, we called for non-communicable diseases (NCDs) to be regarded as a global emergency and we compared the spread of NCDs to climate change, a global emergency of unprecedented proportion. This is not hyperbole—there is ample reason for that claim. NCDs present an overwhelming and widespread threat to populations globally and cause more than 70% of global deaths.1 Worldwide, there are more than 1·1 billion people who have high blood pressure, almost 800 000 people die from suicide annually, 425 million adults have diabetes, and about 40% of adults are overweight or obese.

[Comment] Defining primary palliative care for universal health coverage

Thu, 22 Aug 2019 23:00:07 +0000

Much has been achieved in advancing palliative care on the global health agenda, but there is more to do. The 2014 World Health Assembly (WHA) committed countries to integrating palliative care into their health systems and WHO was tasked with monitoring progress.1 By 2017, WHO had updated the definition of universal health coverage (UHC)—Sustainable Development Goal 3.8—to include palliation along with promotion, prevention, treatment, and rehabilitation.2 A Lancet Commission in 2017 highlighted the global need to take action when 61 million people are living with serious health-related suffering due to uncontrolled pain and without access to an affordable essential package for palliative care.

[Comment] From primary health care to universal health coverage—one step forward and two steps back

Thu, 22 Aug 2019 23:00:07 +0000

Primary health care (PHC), codified at the historic 1978 Alma Ata Conference, was advocated as the means to achieve health for all by the year 2000.1 The principles of PHC included universal access and equitable coverage; comprehensive care emphasising disease prevention and health promotion; community and individual participation in health policy, planning, and provision; intersectoral action on health determinants; and appropriate technology and cost-effective use of available resources.2 These principles were to inform health-care provision at all levels of the health system and the programmatic elements of PHC that focused primarily on maternal and child health, communicable diseases, and local social and environmental issues.

[Comment] Progressing polypills beyond concepts to outcomes

Thu, 22 Aug 2019 23:00:07 +0000

In 2001, combined use of blood pressure-lowering drugs, a statin, and aspirin was proposed as a new approach to prevent cardiovascular disease.1 Reconceptualised soon thereafter as a population-level, so-called polypill strategy for all individuals aged 55 years and older, regardless of pretreatment risk factors, a modelling paper2 predicted that this approach would reduce cardiovascular disease by more than 80%. However, to date, empirical data have been scarce. A 2017 Cochrane review update3 identified 13 randomised controlled trials of polypills (defined as fixed-dose combinations of blood pressure-lowering and cholesterol-lowering drugs, with or without aspirin, in a single pill), including 9059 predominantly male participants with age ranging from 53 to 64 years.

[Comment] Strategies to identify patients for antihypertensive treatment

Thu, 22 Aug 2019 23:00:07 +0000

Elevated blood pressure is the major risk factor for disease and premature death globally, and the association between blood pressure and fatal cardiovascular complications is strong.1,2 Antihypertensive treatment can reduce cardiovascular morbidity and all-cause mortality and, supported by evidence summarised in 2018,3 lower target blood pressure values have been introduced into existing recommendations on the management of hypertension.4,5 However, the absolute benefit of antihypertensive treatment in reducing cardiovascular events is determined by the overall cardiovascular risk of the individual.

[Comment] Blood pressure control: a challenge to global health systems

Thu, 22 Aug 2019 23:00:07 +0000

Raised blood pressure is the most important risk factor in the global burden of disease.1 Although there is robust evidence to show that lowering blood pressure can substantially reduce cardiovascular morbidity and mortality,2 the global burden of hypertension is increasing.3,4 To achieve a reduction in the burden of disease related to hypertension, health systems must ensure that high blood pressure treatment and control rates are achieved. The status of controlled blood pressure is being promoted as a measure of universal health coverage, especially in the context of non-communicable diseases.

[Editorial] Proposal to screen all US adult patients for substance use

Thu, 22 Aug 2019 23:00:07 +0000

On Aug 13, the US Preventive Services Task Force (USPSTF) published a draft recommendation on screening for illicit drugs, including the non-medical use of prescription drugs. The announcement comes amid the opioid crisis in the USA and is motivated by the need for early identification of people at risk for drug use. The task force draws on data from a 2017 national survey in which 11·5% of Americans reported illicit drug use with more than 700 000 overdoses. In contrast to the 2008 recommendation against drug screening in both adults and adolescents because of insufficient evidence, for the first time, USPSTF is now advising physicians to screen all adult patients for illicit drug use without biological drug testing.

[Editorial] Better evidence needed for preventing paediatric migraine

Thu, 22 Aug 2019 23:00:07 +0000

Migraines are the most common disabling type of headache among children and adolescents. Globally, of all non-communicable diseases in children aged 5–14 years, migraine ranks third for disease burden after conduct disorder and anxiety disorder. On Aug 14, the American Academy of Neurology (AAN) and the American Headache Society released new guidelines on the pharmacological prevention and acute treatment of migraine in children and adolescents. These are the first updates to AAN guidance in this area in 15 years, and outline that although there are now more evidence-based treatments for acute migraine attacks, finding the right approach for preventing migraines remains a challenge.

[Editorial] Is the concept of hypertension as a disease unhelpful?

Thu, 22 Aug 2019 23:00:07 +0000

Ahead of the annual conference of the European Society of Cardiology together with the World Congress of Cardiology held in Paris, France (Aug 31–Sept 4), this issue's research section is devoted to Articles on hypertension. These Articles paint an interesting picture of the global state of, and discussions about, this important risk factor for cardiovascular diseases and other non-communicable diseases (NCDs). The NCD Risk Factor Collaboration authors show increases in awareness and control in 12 selected high-income countries over the past four decades.

Pfizer Invests $500 Million in Expanding Gene Therapy Facility

Thu, 22 Aug 2019 16:51:45 +0000

Pfizer Inc is investing $500 million to expand a manufacturing facility in Sanford, North Carolina, that plays a central role in its efforts to become a major player in gene therapy, the company said on Wednesday.
Reuters Health Information

Salvadoran Woman Acquitted in Abortion Case Calls for Reform

Thu, 22 Aug 2019 17:01:43 +0000

Evelyn Hernandez has a message for El Salvador's president: End the criminalization of abortion in the conservative Central American country.
Reuters Health Information

Many Dermatologists Need More Training on African American Skin and Hair

Thu, 22 Aug 2019 16:55:12 +0000

When dermatologists have training only with Caucasians, it can lead to frustration and poor care for African American patients, a new U.S. study finds.
Reuters Health Information

Flu Vaccine Recommendations Updated by CDC

Thu, 22 Aug 2019 17:44:44 +0000

New ACIP recommendations include an expanded age indication for one vaccine and a changed dose volume for another vaccine.
Medscape Medical News

FDA Slaps Class I Recall on Sapien 3 Ultra for TAVR

Thu, 22 Aug 2019 13:57:56 +0000

The class I recall of the transcatheter aortic valve replacement (TAVR) device follows an urgent field warning about burst balloons issued last month by device maker, Edwards Lifesciences.
News Alerts

No Survival Benefit with Myocardial Viability After CABG: STICH

Thu, 22 Aug 2019 14:22:02 +0000

Past research suggested that myocardial viability might aid survival in coronary bypass surgery patients. This study found no long-term survival benefit but modest improvement in ejection fraction.
Medscape Medical News

«Это такая репетиция аккредитации, которая ждет каждого выпускника»

Thu, 22 Aug 2019 19:04:06 +0000

Сегодня каждый старшекурсник получил возможность провести независимый аудит своих знаний, приняв участие в олимпиаде студентов «Я — профессионал». Секретами того, как стать настоящим профессионалом и взять от учебы в вузе по максимуму, поделились победители главного интеллектуального соревнования российских студентов по медицинским направлениям и их преподаватели.

More Evidence for Neurofilament Light Chain as MS Biomarker

Thu, 22 Aug 2019 12:20:20 +0000

Tracking sNfL levels over time corresponds to multiple sclerosis disease course in a longitudinal study, but use of the blood biomarker for individual prognosis remains unclear.
Medscape Medical News

Full Chemo Doses Early On Maximize Breast Cancer Survival

Thu, 22 Aug 2019 11:35:33 +0000

'The juice is worth the squeeze,' say experts, who warn against reducing the dose of adjuvant chemotherapy because it may lower survival.
Medscape Medical News

Use of Marijuana, Meth, Hallucinogens Up in New SAMHSA Survey

Thu, 22 Aug 2019 10:06:21 +0000

A new national survey shows increased use of marijuana, methamphetamines, and hallucinogens in 2018 vs 2017, along with decreases in use of cocaine and heroin.
Medscape Medical News

Домашние животные могут помочь пожилым людям справиться с хронической болью

Thu, 22 Aug 2019 15:04:02 +0000

Исследование с участием пожилых людей старше 70 лет показало, что частое общение с домашними животными помогает справиться с хроническими болями, а также благотворно влияет на двигательную активность и соблюдение режима дня.

Air Pollution Linked to Psychiatric Illness

Thu, 22 Aug 2019 06:13:04 +0000

New research has uncovered a strong link between air pollution exposure and an increase in the prevalence of psychiatric disorders, especially bipolar disorder.
Medscape Medical News

Почему пьянство может быть вреднее для женщин

Thu, 22 Aug 2019 09:23:01 +0000

В ходе проведенного на крысах исследования влияния алкоголя было установлено, что у самок концентрация алкоголя в крови в два раза выше, чем у самцов. Кроме того, из-за спиртного повышается уровень белка, способствующего росту опухолей: на 20% у самцов крыс, а у самок — на 95%.

Teva Launches Generic Version of EpiPen for Young Children

Thu, 22 Aug 2019 00:52:50 +0000

Teva Pharmaceutical Industries Ltd on Tuesday made its generic version of Mylan's EpiPen for young children available in most retail pharmacies at $300 for a 2-pack.
Reuters Health Information

Glecaprevir-Pibrentasvir Effective for Hepatitis C After Treatment Failure

Thu, 22 Aug 2019 00:48:00 +0000

The direct-acting antiviral (DAA) combination of glecaprevir and pibrentasvir is effective in patients with genotype 1 hepatitis C virus (HCV) infection after failure of treatment with sofosbuvir plus an NS5A inhibitor, according to results from a new open-label trial.
Reuters Health Information

One in Eight Patients Get Pacemaker a Year After TAVI With Sapien 3

Wed, 21 Aug 2019 21:57:20 +0000

A year after undergoing transcatheter aortic-valve implantation (TAVI) with the Edwards SAPIEN 3 prosthesis, the incidence of conduction abnormalities requiring pacemaker implantation is "relatively low," according to Dutch researchers.
Reuters Health Information

Heart Failure Patients With HIV Face Higher Risk of Sudden Cardiac Death

Wed, 21 Aug 2019 22:01:41 +0000

The risk of sudden cardiac death (SCD) appears to be higher among heart failure patients who also have HIV infection, according to new findings.
Reuters Health Information

Bacteremic UTI in Infants Can Be Managed With Shorter-Course Parenteral Antibiotics

Wed, 21 Aug 2019 21:49:20 +0000

Recurrent urinary-tract infections (UTIs) are no more frequent among infants with bacteremic UTI who receive shorter versus longer parenteral antibiotic treatment, according to a retrospective study.
Reuters Health Information

Nursing Home Residents With Advanced Dementia Often Overtreated at End of Life

Wed, 21 Aug 2019 21:49:25 +0000

Nursing home residents with advanced dementia, especially men, receive "burdensome interventions" and antibiotics in their final days, a population-based study in Canada reveals.
Reuters Health Information

Cardinal Health Warns Ongoing Opioid-Related Lawsuits to Hit Business

Wed, 21 Aug 2019 21:36:04 +0000

Drug distributor Cardinal Health Inc warned on Tuesday that its business could be hurt as it defends itself against several opioid-related lawsuits.
Reuters Health Information

High Levels of Exhaust Pollutants May Raise Risk for AMD

Wed, 21 Aug 2019 21:36:15 +0000

Exposure to high levels of exhaust may raise the risk of age-related macular degeneration (AMD), a new study suggests.
Reuters Health Information

Embattled VA Pathologist Charged With Deaths of Three Veterans

Wed, 21 Aug 2019 19:32:39 +0000

An Arkansas Veterans Affairs pathologist was indicted for wire fraud, mail fraud, making false statements, and involuntary manslaughter after being arrested on federal charges.
Medscape Medical News

RELAX-AHF-2 Results on Serelaxin in Acute Heart Failure Published

Wed, 21 Aug 2019 18:33:28 +0000

The trial failed to hit the primary endpoints of cardiovascular death or worsening heart failure, but the serelaxin story may not be dead, according to the trial's PI.
Medscape Medical News

Stage Set for Big Measles Outbreaks in Texas, Other States

Wed, 21 Aug 2019 13:47:21 +0000

The high — and rising — rate of nonmedical vaccine exemptions has left major metropolitan areas vulnerable to measles outbreaks; other states have similar pockets of undervaccinated schoolchildren.
Medscape Medical News

'Sweet Spot' of Optimal Compressions, Depth Identified in CPR

Wed, 21 Aug 2019 14:04:46 +0000

Balancing compression rate and speed in CPR is challenging. This study suggested an optimal combination, enhanced when a CPR device is used.
Medscape Medical News

Multiple Hospitals Close in Wake of Fraud Allegations

Wed, 21 Aug 2019 14:16:00 +0000

Jorge A. Perez and his management company, EmpowerHMS, helped run an empire of rural hospitals. Now, 12 of them have entered bankruptcy and eight have closed their doors. So, what happened?
Kaiser Health News

CDC Investigating Surge of Vaping-Linked Respiratory Illness

Wed, 21 Aug 2019 13:29:48 +0000

Cases of severe respiratory illness associated with use of e-cigarette products for "vaping" have spiked during the last 2 months, according to the CDC.
Medscape Medical News

Возможно, есть связь между вейпингом и тяжелыми заболеваниями легких

Wed, 21 Aug 2019 19:28:21 +0000

Летом в американские больницы с тяжелыми легочными заболеваниями попали около 120 взрослых и подростков, увлекавшихся вейпингом. Центры по контролю и профилактике заболеваний США предупредили о том, что использование электронных сигарет небезопасно для детей, подростков и молодых людей.

What the Trump Home Dialysis Plan Would Really Look Like

Wed, 21 Aug 2019 12:07:02 +0000

It takes more than an executive order to shift kidney disease patients from dialysis centers to home care. These patients show it takes discipline, skill, will and support.
Kaiser Health News

Physician-Assisted Dying: Even When Legal, Difficult to Achieve

Wed, 21 Aug 2019 10:52:38 +0000

Nine jurisdictions in the US now allow physician-assisted dying. But an overly complicated process plus lack of physician training poses formidable obstacles to patients who choose this option.
Medscape Medical News

Drugmaker Endo to Pay $10 Million to Settle Opioid Case Ahead of Trial

Wed, 21 Aug 2019 10:45:37 +0000

Endo International Plc on Tuesday said it had agreed to pay $10 million to avoid going to trial in October in a landmark case by two Ohio counties accusing various drug manufacturers and distributors of fueling the U.S. opioid epidemic.
Reuters Health Information

One in Four Patients Concerned About Diabetes Drug Costs

Wed, 21 Aug 2019 09:51:02 +0000

Although the report did not identify insulin specifically, it did show how age, gender, and insurance status affected two main strategies patients with diabetes used to cut medication costs.
Medscape Medical News

'Smoldering' Rimmed Lesions in MS Linked to Worse Outcomes

Wed, 21 Aug 2019 09:51:41 +0000

The prospective study, using high-powered MRI, shows multiple chronic active lesions are a "negative prognostic marker" in MS.
Medscape Medical News

How Do You Feel About the ROS?

Wed, 21 Aug 2019 09:59:10 +0000

Is the 'review of systems' an indispensable tool of medicine or a nuisance imposed by excessive bureaucracy?
Medscape Reader Polls

Невероятный спрос на косметическую хирургию связан с дискриминацией по возрасту

Wed, 21 Aug 2019 14:56:13 +0000

В американском исследовании «Дискриминация по возрасту и здоровье пациентов, прибегающих к косметическим процедурам», показано, что возрастная дискриминация понижает общую самооценку, может вызвать проблемы со здоровьем и заставляет людей обращаться в косметические клиники.

CA Data Suggest 'No Progress' in Sex Misconduct in Medicine

Wed, 21 Aug 2019 06:34:11 +0000

One advocate said occurrence of sexual misconduct in medicine is 'deep and wide.' A work group of the Federation of State Medical Boards will issue draft guidance on the topic later in 2019.
Medscape Medical News

Свет защищает сердце

Wed, 21 Aug 2019 08:56:02 +0000

Использование интенсивной световой терапии может помочь уменьшить повреждение тканей, которое происходит во время инфаркта. Исследование, проведенное на мышах и здоровых людях, показало, что свет положительно влияет на циркадные гены и регулируемый ими суточный ритм сердечных сокращений.

TNF Inhibitors Linked to Higher Weight, BMI in Psoriasis Patients

Tue, 20 Aug 2019 23:11:16 +0000

Biologic therapies - particularly tumor necrosis factor inhibitors (TNFi) - are associated with increases in body weight (BW) and BMI in psoriasis patients, according to a new systematic review.
Reuters Health Information

Sleep Quality May Be Linked With Success During Military Basic Training

Tue, 20 Aug 2019 23:16:01 +0000

Soldiers who experience sleep problems during basic combat training may be more likely to struggle with psychological distress, attention difficulties, and anger issues during their entry into the military, a recent study suggests.
Reuters Health Information

Planned Parenthood Turns Down U.S. Subsidies in Fight Over Abortion Referrals

Tue, 20 Aug 2019 23:04:19 +0000

Planned Parenthood said on Monday it would no longer accept grants from a federal program subsidizing reproductive healthcare for low-income women after the Trump administration banned participants in the program from referring women to abortion providers.
Reuters Health Information

Trustworthiness of American College of Physicians Guidelines Relies on COI Disclosure, Management

Tue, 20 Aug 2019 23:04:09 +0000

The American College of Physicians (ACP) has a comprehensive process for disclosing interests and managing potential conflicts of interest for any person involved in the development of an ACP clinical guideline or guidance statement.
Reuters Health Information

FDA Denies Approval for Duchenne Muscular Dystrophy Drug

Tue, 20 Aug 2019 17:03:13 +0000

The FDA has nixed approval of golodirsen injection for the treatment of Duchenne muscular dystrophy, citing concerns over risk for infusion port infections and possible renal toxicity.
Medscape Medical News

Fat-Soluble Statins May Alter Liver Ca Risk in Chronic Hepatitis

Tue, 20 Aug 2019 16:01:07 +0000

Data from a nationwide population with confirmed viral hepatitis suggest that fat-soluble statins may exert unique, class-specific hepatoprotective effects.
Medscape Medical News

DIY Tech Gives People More Freedom in Managing Diabetes

Tue, 20 Aug 2019 15:05:25 +0000

People with diabetes say they've been waiting for better technology to manage their condition. Some tech-savvy, do-it-yourselfers are constructing their own devices using open-source programming instructions.
Kaiser Health News

Poison Center Calls Spike After Medical Marijuana Legalized

Tue, 20 Aug 2019 15:21:28 +0000

Rates of marijuana exposure cases in children and teens reported to a poison control center have doubled since Massachusetts legalized medical marijuana in 2012.
Medscape Medical News

CVD Risk for Ex-Smokers May Linger a Decade or More

Tue, 20 Aug 2019 14:44:18 +0000

Cardiovascular disease risk dips drastically after quitting smoking, but it may take 10 to 15 years for the risk of former smokers to reach that of 'never smokers,' much longer than previously thought.
Medscape Medical News

Каких руководителей не хватает российскому здравоохранению

Tue, 20 Aug 2019 19:21:37 +0000

Российскому здравоохранению не хватает денег. При этом часто для того, чтобы бюджет медучреждения перестал быть бездонной черной дырой, его руководству не хватает квалификации и умения правильно тратить деньги, считают эксперты. Каким должен быть руководитель клиники, рассказывает директор Центра развития здравоохранения Московской школы управления «СКОЛКОВО» Наталья Комарова.

Stem Cell Agency to Ask for New Funds Despite Failed Promises

Tue, 20 Aug 2019 13:29:56 +0000

California's stem cell agency is almost out of money. Its supporters plan to ask voters for more funding next year, even though no agency-funded treatments have been approved for widespread use.
Kaiser Health News

DAPA-HF Top-Line Results: Dapagliflozin Hits Primary Outcome

Tue, 20 Aug 2019 13:35:46 +0000

The SGLT2 inhibitor dapagliflozin provided significant and clinically meaningful reductions in heart failure outcomes, according to the sponsoring company.
Medscape Medical News

Каких руководителей не хватает российскому здравоохранению

Tue, 20 Aug 2019 19:21:37 +0000

Thyroid Function Test Abnormalities Linked to Preterm Birth

Tue, 20 Aug 2019 11:00:16 +0000

Risk of very preterm birth is notably higher with isolated hypothyroxinemia and thyroid peroxidase-antibody positivity, a new analysis shows, but evidence is lacking on possible benefits of treatment.
Medscape Medical News

USPSTF Recommendations on BRCA Mutation Testing

Tue, 20 Aug 2019 11:00:53 +0000

Women at increased risk for cancers associated with BRCA gene mutations should be assessed, and then counseled and tested if indicated.
Medscape Medical News

Gallbladder, Biliary Tract Events Increased With Liraglutide

Tue, 20 Aug 2019 11:42:52 +0000

Post-hoc analysis from the LEADER trial explores the relevant factors and potential mechanisms.
Medscape Medical News

Gadolinium Exposure Risk Highest in Early Pregnancy

Tue, 20 Aug 2019 10:00:43 +0000

Pregnancy screening is key in preventing inadvertent exposure to gadolinium among women who undergo contrast-enhanced imaging procedures, a study found.
Medscape Medical News

Aerosols in e-Cigs Harm Vasculature, Even Without Nicotine

Tue, 20 Aug 2019 10:01:04 +0000

The impact of vaping on long-term health is unknown, but inhaling aerosols from a nicotine-free e-cigarette produces a transient harmful effect on blood vessels, a study found.
Medscape Medical News

Скандинавская ходьба уменьшает негативные последствия рака молочной железы

Tue, 20 Aug 2019 13:58:42 +0000

Физическая активность в виде скандинавской ходьбы способствует успешной реабилитации после рака молочной железы, как показал научный обзор исследований, проведенный испанскими учеными.

Docs, Nurses Weigh in on Use of Terms 'Providers,' 'Consumers'

Tue, 20 Aug 2019 06:47:01 +0000

A Medscape poll shows physicians are much more likely to find the term "provider" undesirable and much less likely to view patients as "consumers" than nurses/APRNs.
Medscape Medical News

Активированный уголь усиливает действие ацикловира против герпеса

Tue, 20 Aug 2019 09:15:35 +0000

Комбинация ацикловира и активированного угля делает лекарственный препарат против вируса простого герпеса более эффективным, позволяет уменьшить дозировку и общий курс лечения, согласно американскому исследованию.

UC Disease Course Similar for Smokers, Non-Smokers

Mon, 19 Aug 2019 23:39:11 +0000

A new study adds to evidence that smoking does not improve disease outcomes in ulcerative colitis (UC) and that kicking the habit will not worsen the disease, as some have thought.
Reuters Health Information

Metformin Use During Pregnancy May Alter Babies' Growth Patterns

Mon, 19 Aug 2019 23:43:27 +0000

Metformin use during pregnancy may alter the trajectory of fetal, infant and childhood growth, a new systematic review and meta-analysis suggest.
Reuters Health Information

First Two Ebola Cases Confirmed in Congo's South Kivu - Officials

Mon, 19 Aug 2019 23:47:18 +0000

A woman and her child were the first two cases confirmed with Ebola in Congo's South Kivu region this week, opening a new front in the fight against the outbreak.
Reuters Health Information

"Until Her Bones Are Broken": Myanmar Activists Fight to Outlaw Domestic Violence

Mon, 19 Aug 2019 23:51:20 +0000

Cradling her one-year-old daughter in a house in southern Myanmar, 22-year-old Nu Nu Aye recalled the reasons her husband gave for beating her. She hadn't looked after his rooster. She wouldn't have sex with him.
Reuters Health Information

Bowel Preparation Does Not Reduce Morbidity of Elective Colectomy

Mon, 19 Aug 2019 23:21:22 +0000

Mechanical and oral antibiotic bowel preparation (MOABP) does not reduce surgical site infections (SSIs) or overall morbidity after elective colectomy, compared with no bowel preparation, according to results from the MOBILE trial.
Reuters Health Information

Crisis for Severe Malaria Treatment in United States

Mon, 19 Aug 2019 18:00:09 +0000

The last stocks of the only FDA-approved injectable drug for severe malaria expired in April, compassionate access to the only alternative is at least 8 hours away, and hospitals need emergency plans.
Medscape Medical News

FDA OKs First-in-Class Antibiotic Lefamulin (Xenleta) for CABP

Mon, 19 Aug 2019 18:00:57 +0000

The new semisynthetic pleuromutilin antibiotic will be available for oral and IV administration with a short 5- to 7-day course of therapy for community-acquired bacterial pneumonia (CABP).
FDA Approvals

Solid, Hematological Malignancies Show Different Responses to Zoster Vaccines

Mon, 19 Aug 2019 17:44:25 +0000

Inactivated varicella zoster virus (VZV) vaccine elicits protective responses in immunosuppressed patients with solid tumor malignancies, whereas patients with hematological malignancies respond to adjuvanted recombinant zoster vaccine, according to a pair of new studies.
Reuters Health Information

Mother's Voice May Shield Sleeping Newborn From NICU Noise

Mon, 19 Aug 2019 17:37:42 +0000

Babies in the neonatal ICU who are exposed to their mothers' voice during sleep are less likely to awaken after loud bursts of ambient noise, especially if they were born at or after 35 weeks' gestation, researchers say.
Reuters Health Information

Overscreening, Undertreatment Common for Cancers in the "Oldest Old"

Mon, 19 Aug 2019 17:31:22 +0000

Cancers diagnosed after age 85 are more likely to be found at a later stage - despite over-screening in this age group - and are less likely to be treated surgically, a large observational study reveals.
Reuters Health Information

Choking Hazard: Another Reason to Skip Supplements

Mon, 19 Aug 2019 17:01:24 +0000

Multivitamin and calcium supplements often lodged in older adults' throats, presenting a preventable choking hazard, a study found.
Medscape Medical News

Anti-Migraine Drug Recalled Due to Potential Contamination

Mon, 19 Aug 2019 17:20:53 +0000

The voluntary recall of eletriptan hydrobromide 40-mg tablets is due to potential contamination with Pseudomonas and Burkholderia bacteria, the manufacturer has announced.
News Alerts

PBMs Pass on Rebates to Part D Drug Plans: GAO

Mon, 19 Aug 2019 17:44:13 +0000

The finding is relevant to the congressional debate over whether drug rebates should be passed on to consumers.
Medscape Medical News

As Americans Get Heavier, Obesity-Linked Cancers May Strike Earlier

Mon, 19 Aug 2019 16:47:08 +0000

Increasing numbers of middle-aged Americans appear to be developing cancers that can be associated with obesity, new data suggest.
Reuters Health Information

Tobacco Industry Anti-Smoking Ads Reached Less Than Half of U.S. Adults

Mon, 19 Aug 2019 16:44:23 +0000

Court-ordered anti-smoking ads sponsored by the tobacco industry reached only around 40% of adults and about half of all smokers in the U.S., a recent study suggests.
Reuters Health Information

The Power of Flowers May Ease Fibromyalgia Symptoms

Mon, 19 Aug 2019 16:04:08 +0000

The beneficial impact of floristry on pain and psychiatric symptoms may be due to a multistimulatory effect that involves different senses, researchers suggest.
Medscape Medical News

Diabetes Overtreatment in Complex Patients Common, Dangerous

Mon, 19 Aug 2019 14:51:02 +0000

Many patients with type 2 diabetes are overtreated, leading to more than 9000 preventable hospital visits over 2 years, a modeling study found.
Medscape Medical News

Making the Leap to Patient Decision Aid Adoption

Mon, 19 Aug 2019 14:45:03 +0000

By designing a PDA that not only appeals to patients, but also is friendly to physicians, researchers appear to have crossed the threshold of making something that's adoptable, one observer says.
Medscape Medical News

FDA Approves Upadacitinib (Rinvoq), New JAK Inhibitor for RA

Mon, 19 Aug 2019 13:19:15 +0000

Upadacitinib is for adults with moderately to severely active rheumatoid arthritis who fail to respond adequately or are intolerant to methotrexate.
FDA Approvals

Дети с легкой формой астмы могут использовать ингаляторы по мере необходимости

Mon, 19 Aug 2019 19:10:51 +0000

Исследование ученых из Медицинской школы Вашингтонского университета (Сент-Луис) показало, что дети с легкой формой астмы могут эффективно справляться с заболеванием, используя при появлении симптомов два ингалятора: один предохранительный, со стероидами, а второй — для неотложной помощи, с бронхолитиками.

Prenatal Fluoride Exposure and IQ in Kids: Is There a Link?

Mon, 19 Aug 2019 11:36:36 +0000

Though a new study, which uses a biomarker and robust methodology, suggests there is a link, experts point to study limitations and suggest caution in drawing conclusions from the findings.
Medscape Medical News

Пожилые пациенты часто страдают от бессимптомного инсульта после операции

Mon, 19 Aug 2019 14:03:15 +0000

Обследование более тысячи человек из разных частей света показало, что примерно у одного из 14 пожилых пациентов после операции происходил бессимптомный («тихий») инсульт. Риск «тихого» инсульта врачам необходимо учитывать при работе с пациентами старше 65 лет.

Виновны в сострадании

Mon, 19 Aug 2019 09:04:33 +0000

Российские силовики продолжают бороться с врачами и их пациентами: в последние дни стало известно о двух уголовных делах по тяжелым «наркотическим» статьям. Реальные сроки угрожают врачу, выдавшему тяжелой больной ампулу обезболивающего из собственных запасов, и матери тяжелобольного ребенка, заказавшей для него по почте незарегистрированный в стране лекарственный препарат.

Trump Rule Targeting Poor Immigrants Could Harm Children, Health - Advocates

Sat, 17 Aug 2019 23:56:16 +0000

A Trump administration plan to cut legal immigration by poor people will likely result in sicker children, more communicable diseases and greater homelessness in the United States, according to immigrant advocates and the federal government's own analysis.
Reuters Health Information

Guselkumab May Have Edge Over Secukinumab in Long-Term Control of Psoriasis

Sat, 17 Aug 2019 23:56:24 +0000

For moderate-to-severe plaque psoriasis, treatment with guselkumab was superior to secukinumab based on 90% or better improvement from baseline in patients' Psoriasis Area and Severity Index score (PASI 90) at 48 weeks in the ECLIPSE study.
Reuters Health Information

Surgeons Not Good at Predicting Benefit From Knee Operations

Sun, 18 Aug 2019 00:07:30 +0000

Surgeons are no better at determining which patients might benefit from operations to treat torn knee cartilage than if they just flipped a coin, a new study suggests.
Reuters Health Information

Disparities in Access to Best Stroke Treatment

Sun, 18 Aug 2019 00:01:51 +0000

Less than 10% of U.S. stroke patients get a treatment that evidence shows is most effective for ischemic stroke – and the odds are even lower for patients who are black and Hispanic, a U.S. study suggests.
Reuters Health Information

U.S. FDA Proposes New Health Warnings on Cigarette Packs, Advertisements

Sat, 17 Aug 2019 23:49:27 +0000

The U.S. Food and Drug Administration on Thursday proposed new health warnings for cigarette packages and advertisements, as small size and lack of an image in current warnings make them virtually invisible.
Reuters Health Information

Surgical Training Programs Not Supportive of New Parents

Sat, 17 Aug 2019 23:49:31 +0000

Surgical residents say it's tough to have children during their five years of intensive training due to a lack of flexibility in program requirements and lack of support from peers and faculty.
Reuters Health Information

Low Vitamin D Linked to Worse Parkinson's Symptoms

Sat, 17 Aug 2019 14:55:03 +0000

Parkinson's disease (PD) patients have lower levels of vitamin D than their healthy peers, a new study confirms.
Reuters Health Information

Finger-to-Nose Test May Refine Prehospital Stroke Recognition

Sat, 17 Aug 2019 14:55:00 +0000

Adding the finger-to-nose (FTN) test to standard screening may better help paramedics to recognize posterior circulation ischemic stroke, according to findings from a small study.
Reuters Health Information

Islet-Allograft Tolerance Possible in Monkeys Without Long-Term Immunosuppression

Sat, 17 Aug 2019 15:01:16 +0000

Long-term tolerance of islet allografts may be possible without prolonged immunosuppression, according to studies in monkeys.
Reuters Health Information

Most Patients Don't Need Opioids After Endocrine Surgery

Fri, 16 Aug 2019 16:09:44 +0000

According to a recent study, most patients who receive opioids after undergoing routine cervical endocrine surgery do not take them.
Medscape Medical News

FDA Expands Approval for TAVR Valves to Low-risk Patients

Fri, 16 Aug 2019 15:19:22 +0000

The Sapien 3 and Sapien 3 Ultra and the CoreValve Evolut R and CoreValve Evolut PRO were previously indicated only in patients at intermediate or higher surgical risk.
FDA Approvals

As CBD Finds Small-town America, What Do We Tell Its Graying Users?

Fri, 16 Aug 2019 15:31:53 +0000

Skyrocketing demand has outpaced research on cannabidiol, particularly the complexities of its cardiovascular effects, a critical issue for vulnerable older adults whose CBD use is surging.
Medscape Medical News

FDA Clears First Spinal Tether Device for Idiopathic Scoliosis

Fri, 16 Aug 2019 13:36:59 +0000

The Tether Vertebral Body Tethering System from Zimmer Biomet Spine is intended to treat growing children and adolescents whose spinal curves fail to respond to conservative treatment like external bracing.
FDA Approvals

Дышать загрязненным городским воздухом — все равно, что выкуривать по пачке сигарет в день

Fri, 16 Aug 2019 19:12:29 +0000

Новое американское исследование показало, что загрязненный городской воздух может вызывать серьезные заболевания легких. В районах с высоким уровнем концентрации приземного озона в воздухе был выявлен такой рост заболеваемости эмфиземой, как если бы все их жители курили по пачке сигарет в день в течение 29 лет.

FDA Approves Fedratinib for the Treatment of Myelofibrosis

Fri, 16 Aug 2019 12:38:17 +0000

The second drug for myelofibrosis has now been approved, giving patients another option.
FDA Approvals

At Top Medical Journals, Women Are Gaining Ground -- Slowly

Fri, 16 Aug 2019 09:44:14 +0000

Although there has been some progress, a woman's name rarely sits atop the masthead of a major medical journal.
Medscape Medical News

Нормализация артериального давления — путь к здоровому старению мозга

Fri, 16 Aug 2019 14:01:47 +0000

Интенсивный контроль уровня систолического артериального давления при гипертонии замедляет прогрессирование поражения белого вещества в мозге и старение мозга, как выяснили американские исследователи при помощи МРТ.

Прием витамина D во время беременности в будущем снижает риск проблем с зубами у ребенка

Fri, 16 Aug 2019 09:04:28 +0000

У детей женщин, принимавших больше витамина D во время беременности, было меньше повреждений зубной эмали. Это показало исследование датских ученых, которое длилось шесть лет.

Burundi Starts Ebola Vaccines for Health Workers -WHO

Fri, 16 Aug 2019 01:16:25 +0000

Burundi has started vaccinating its health workers against Ebola, beginning with those near the border with the Democratic Republic of Congo, the World Health Organization (WHO) said on Wednesday.
Reuters Health Information

New Evidence Strengthens Link Between Enterovirus and Acute Flaccid Myelitis

Fri, 16 Aug 2019 01:05:14 +0000

Patients with acute flaccid myelitis (AFM) commonly have antibodies to enterovirus (EV) peptides in their cerebrospinal fluid (CSF), further supporting a link between EV and AFM, researchers report.
Reuters Health Information

[Series] Building evidence and measuring clinical outcomes for genomic medicine

Thu, 15 Aug 2019 23:00:10 +0000

Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value across a wide breadth of clinical disciplines. One barrier to widespread adoption is the paucity of evidence for improved outcomes in patients who do not already have an indication for more focused testing. In this Series paper, we review clinical outcome studies in genomic medicine and discuss the important features and key challenges to building evidence for next generation sequencing in the context of routine patient care.

[Series] Family health history: underused for actionable risk assessment

Thu, 15 Aug 2019 23:00:10 +0000

Family health history (FHH) is the most useful means of assessing risk for common chronic diseases. The odds ratio for risk of developing disease with a positive FHH is frequently greater than 2, and actions can be taken to mitigate risk by adhering to screening guidelines, genetic counselling, genetic risk testing, and other screening methods. Challenges to the routine acquisition of FHH include constraints on provider time to collect data and the difficulty in accessing risk calculators. Disease-specific and broader risk assessment software platforms have been developed, many with clinical decision support and informatics interoperability, but few access patient information directly.

[Clinical Picture] Getting to the heart of the matter in a multisystem disorder: Erdheim–Chester disease

Thu, 15 Aug 2019 23:00:10 +0000

A 59-year-old woman was admitted to our emergency department for asthenia and swollen ankles. 1 week earlier she began to feel tired while walking. On clinical examination, we found peripheral oedema but no other signs suggestive of heart failure. Her blood pressure was 150/70 mm Hg. An electrocardiogram showed junctional bradycardia (35 beats per min): P waves were absent and the QRS complexes were regular and narrow. In her medical history, it was noted that she had recently been treated with ibuprofen and colchicine for acute idiopathic pericarditis: the patient had chest pain and paroxysmal atrial flutter.

[Articles] Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study

Thu, 15 Aug 2019 23:00:10 +0000

Arginine-stimulated copeptin measurements are an innovative test for diabetes insipidus with high diagnostic accuracy, and could be a simplified, novel, and safe diagnostic approach to diabetes insipidus in clinical practice.

[Articles] Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent): a randomised, double-blind, active-comparator-controlled phase 3 trial

Thu, 15 Aug 2019 23:00:10 +0000

Risankizumab showed significantly greater efficacy than adalimumab in providing skin clearance in patients with moderate-to-severe plaque psoriasis. No additional safety concerns were identified for patients who switched from adalimumab to risankizumab. Treatment with risankizumab provides flexibility in the long-term treatment of psoriasis.

[Articles] Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series

Thu, 15 Aug 2019 23:00:10 +0000

Early nerve transfer surgery is a safe and effective addition to surgical techniques for upper limb reanimation in tetraplegia. Nerve transfers can lead to significant functional improvement and can be successfully combined with tendon transfers to maximise functional benefits.

[Correspondence] Intrahepatic cholestasis: suggested future investigations – Authors' reply

Thu, 15 Aug 2019 23:00:10 +0000

We share the concerns of Alexandre Vivanti and colleagues about the high proportion of iatrogenic preterm births for women with intrahepatic cholestasis of pregnancy (ICP)identified in our study.1 These births occurred for women with bile acids at all concentrations, the overall proportion being 817 (19%) of 4316 women with singleton pregnancies included in the individual patient data analysis,1 which is much higher than the typical proportion of all-cause preterm births (the estimated global proportion of preterm births for 2014 was 10·6% [uncertainty interval 9·0–12·0]2).

[Correspondence] Intrahepatic cholestasis: suggested future investigations

Thu, 15 Aug 2019 23:00:10 +0000

We read with great interest Caroline Ovadia and colleagues' Article.1 We congratulate the authors for aggregating such large-scale individual data to determine how perinatal outcomes are linked with bile acid concentrations. The authors focus on stillbirth but show another important finding. Iatrogenic preterm birth is a matter of concern (it occurred in 305 [11·8%] of 2576 women with intrahepatic cholestasis of pregnancy (ICP) vs 2440 [2·0%] of 121 011 women in the control group; odds ratio 3·65, 95% CI 1·94–6·85), and we noticed a significantly increased number of admissions to neonatal intensive care units (517 [23·7%] of 2175 women vs 3367 [12·9%] of 26 005; 2·12, 1·48–3·03), with most births close to term and no difference in birthweight centile (p 15 of the Article's1 appendix).

[Correspondence] Pain relief during labour – Authors' reply

Thu, 15 Aug 2019 23:00:10 +0000

We thank all the correspondents for their interest in the RESPITE trial1 and their recognition of its value. We would like to take the opportunity to respond to some of the points raised.

[Correspondence] Pain relief during labour

Thu, 15 Aug 2019 23:00:10 +0000

Matthew Wilson and colleagues1 found that remifentanil patient-controlled analgesia halved the proportion of epidural conversions compared with intramuscular pethidine. We believe there was a flaw in this research because the study lacked data on birth order, and primigravidae report more pain than multiparous women.2 We believe that addressing this issue could further increase the value of their study.

[Correspondence] Pain relief during labour

Thu, 15 Aug 2019 23:00:10 +0000

We read the Article by Matthew Wilson and colleagues1 with interest. Their study findings add weight to the argument that remifentanil is an increasingly preferable pharmacological alternative to pethidine for labour analgesia and that it reduces conversion rates to epidural analgesia. However, the investigators have overlooked the substantial staffing implications that the widespread adoption of remifentanil would have on maternity units.

[Correspondence] Pain relief during labour

Thu, 15 Aug 2019 23:00:10 +0000

Although we appreciate the value of the work by Matthew Wilson and colleagues1 on remifentanil patient-controlled analgesia (PCA) versus intramuscular pethidine for pain relief in labour, we have concerns about the study and its interpretation.

[Correspondence] Pain relief during labour

Thu, 15 Aug 2019 23:00:09 +0000

Matthew Wilson and colleagues should be congratulated for their well designed and executed study.1 However, several findings were inadequately addressed and affect their conclusions.

[Correspondence] Zhang's guidelines vs WHO guidelines for diagnosing labour dystocia – Authors' reply

Thu, 15 Aug 2019 23:00:09 +0000

We thank Annie Kroushev and her colleagues for their interest in our article that described our investigation of the effect of different labour progression guidelines.1

[Correspondence] Zhang's guidelines vs WHO guidelines for diagnosing labour dystocia

Thu, 15 Aug 2019 23:00:09 +0000

In their multicentre, cluster-randomised controlled trial, Stine Bernitz and colleagues1 found no significant difference in the frequency of intrapartum caesarean section (ICS) between the obstetric units adhering to the WHO partograph and those adhering to Zhang's guideline. However, some inevitable biases would have existed since the assignment could not be blinded to health-care providers.

[Correspondence] Zhang's guidelines vs WHO guidelines for diagnosing labour dystocia

Thu, 15 Aug 2019 23:00:09 +0000

We read with interest the Labour Progression Study (LaPS) by Stine Bernitz and colleagues1, which reported no differences between Zhang's guidelines and WHO guidelines for diagnosing labour dystocia.

[Correspondence] Prepregnancy calcium supplementation and pre-eclampsia – Author's reply

Thu, 15 Aug 2019 23:00:09 +0000

I thank the correspondents for their comments on our Article.1 In response to Antonio Ponzetto and colleagues, we did not test for Helicobacter pylori infection and, therefore, are not able to comment on its prevalence in our population. However, because of the randomised, double-blind, placebo-controlled study design that was used in the Calcium and Pre-eclampsia (CAP) trial, the occurrence of H pylori infection and the many other possible causative factors for pre-eclampsia would be expected to have been equally distributed between the study groups.

[Correspondence] Prepregnancy calcium supplementation and pre-eclampsia

Thu, 15 Aug 2019 23:00:09 +0000

In their multicentre, randomised controlled trial, G Justsus Hofmeyr and colleagues1 showed that prepregnancy or early pregnancy calcium supplementation led to a significant reduction in recurrent pre-eclampsia among participants with more than 80% compliance and in recurrent pre-eclampsia or pregnancy loss at any gestation. However, we are concerned about the external validity of the study.

[Correspondence] Prepregnancy calcium supplementation and pre-eclampsia

Thu, 15 Aug 2019 23:00:09 +0000

G Justus Hofmeyr and colleagues1 report a very high risk of pre-eclampsia among pregnant women in their double-blind study in South Africa, Zimbabwe, and Argentina. The risk was not reduced by prepregnancy calcium supplementation. They disregarded an important determinant of pre-eclampsia, infection by strains of Helicobacter pylori expressing CagA, an immunodominant determinant endowed with an increased inflammatory potential.2 In Turin, Italy, the association of pre-eclampsia with infection by pathogenic H pylori is strong, especially for pre-eclamptic women who gave birth to small-for-gestational-age babies.

[Department of Error] Department of Error

Thu, 15 Aug 2019 23:00:09 +0000

Chiang C-Y, Van Deun A, Trébucq A, et al. Multidrug-resistant tuberculosis. Lancet 2019; 394: 299—The appendix of this Correspondence has been added as of July 31, 2019.

[Department of Error] Department of Error

Thu, 15 Aug 2019 23:00:09 +0000

Reich K, Gooderham M, Thaçi D, et al. Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent): a randomised, double-blind, active-comparator-controlled phase 3 trial. Lancet 2019; 394: 576–86—In this Article, part of the legend of figure 3 should read “*p=0·0142 versus adalimumab”. This corrections has been made to the online version as of July 16, 2019, and the printed version is correct.

[Correspondence] Coroners' investigations of stillbirths

Thu, 15 Aug 2019 23:00:09 +0000

As a practising senior coroner and a physician, we were surprised by the immediate positive stance taken in by the Editors1 on the topic of progress in investigating stillbirths. The UK Government's proposal for coroners to have the power to investigate full-term stillbirths2 was subject to consultation until June 18, 2019, and we hope all those with an interest in this field to responded accordingly. Feedback is expected in September, 2019.

[Correspondence] Enhancing the National Family Health Survey-5 for policy making

Thu, 15 Aug 2019 23:00:09 +0000

India contributes substantially to the global burden of neonatal deaths and stillbirths.1 It will soon embark on round five of the National Family Health Survey (NFHS), the major household survey used to guide policy making and programme planning for maternal and child health. We highlight two issues that are important for the NFHS to address to effectively contribute to the India National Action Plan (INAP), which aims to reduce the proportion of neonatal deaths and preventable stillbirths to single digits (<10 neonatal deaths per 1000 livebirths and <10 stillbirths per 1000 births) in India by 2030.

[Correspondence] Scientific leadership: the Italian Government's perspective

Thu, 15 Aug 2019 23:00:09 +0000

A number of articles in high impact medical journals in the past few months1–3 report on the alleged anti-scientific attitude of the present Italian Government.

[Correspondence] Health worker gap in Italy: the untold truth

Thu, 15 Aug 2019 23:00:09 +0000

I read with interest the World Report by Marta Paterlini1 about the shortfall of doctors in Italy. I commend Paterlini for highlighting this unsolved problem, but unfortunately, the piece fails to identify its real cause. Born, raised, and trained as an anaesthesiologist in Italy, then re-trained in the USA, I have had the privilege of living and working in different countries, and in my opinion, this issue is far from being addressed in a thorough and systematic way.

[Correspondence] SGLT-2 inhibitors for people with type 2 diabetes – Authors' reply

Thu, 15 Aug 2019 23:00:09 +0000

German Malaga and Eloy F Ruiz suggest that some patients might perceive that the cost and side-effects of sodium-glucose co-transporter-2 inhibitors (SGLT2i) could outweigh the benefit in terms of reduction in cardiovascular and renal events.1 It should go without saying that shared decision making between the doctor and patient is always prudent.

[Correspondence] SGLT-2 inhibitors for people with type 2 diabetes

Thu, 15 Aug 2019 23:00:09 +0000

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) seem promising for the prevention and treatment of cardiovascular disease, as shown in a study by Zelniker and colleagues.1 They are now suggested as second-line therapy for most patients with type 2 diabetes.2 However, important questions remain open for an important patient group, older patients (particularly those older than 80 years).

[Correspondence] SGLT-2 inhibitors for people with type 2 diabetes

Thu, 15 Aug 2019 23:00:09 +0000

Evidence that sodium-glucose co-transporter-2 inhibitors (SGLT2i) can reduce cardiovascular risk—with trials1,2 showing reductions in cardiovascular death, myocardial infarction, and stroke—would suggest they have much to offer in the care of patients with type 2 diabetes at high risk of cardiovascular events. But should they be used in patients at low risk?

[Correspondence] Bringing closure: towards achieving a better understanding of Israel

Thu, 15 Aug 2019 23:00:09 +0000

We wholeheartedly endorse Richard Horton's timely Comment,1 in which he addresses the global rise of anti-Semitism particularly evident in Europe and the USA. Horton stresses the need to educate medical students and health-care professionals of the evil and disastrous consequences of ignoring the historical reality of the Holocaust. It will remind the world, 75 years on, that the call Never Again remains highly relevant!

[Obituary] Marshall Leonard Marinker

Thu, 15 Aug 2019 23:00:08 +0000

General practitioner with a creative influence. He was born in London, UK, on March 2, 1930, and died there from the complications of leukaemia on June 10, 2019, aged 89 years.

[Perspectives] Type 2 diabetes

Thu, 15 Aug 2019 23:00:08 +0000

In the space of a few months in 1921, an acute and terminal disease—type 1 diabetes—became a manageable chronic condition. The discovery of insulin by Frederick Banting, Charles Best, and their colleagues captured a mood of therapeutic optimism, the hope that a new scientific medicine, rooted in the laboratory and working through the networks of industry and state health care, could find cures for all diseases. But insulin therapy, clinicians soon realised, was effective in only a minority of patients.

[Perspectives] Digital orthodoxy of human data collection

Thu, 15 Aug 2019 23:00:08 +0000

The notion that more data are more informative has helped lay the foundation for a new era in medical diagnostics. But this “kitchen sink” approach can be misguided. A classic example is a middle-aged executive without any symptoms who undergoes a yearly health check that sets off a cascade of additional testing, sometimes invasive and not without risk but often without any benefit except for the creation of revenue. That example precedes today's data collection technologies of whole genome sequencing (WGS), wearable biosensors, high-resolution imaging, gut microbiome metagenomics, and more.

[Perspectives] Patrice Harris, President of the American Medical Association

Thu, 15 Aug 2019 23:00:08 +0000

When Patrice A Harris describes what it was like to grow up in the small southern town of Bluefield, WV, USA, her memories sound idyllic: high school football games on Friday nights, where she performed as a majorette and a cheerleader, and Sunday dinners with a big extended family. She calls it “a great place to grow up”, with her schoolteacher mother, a father who worked on the railroad, and grandfathers and neighbours who worked in the coal mines. It's a long way from life in “the heart of coal country” to becoming the first African American woman President of the American Medical Association (AMA), a post she took up in June, 2019.

[Comment] Heat and health: a forthcoming Lancet Series

Thu, 15 Aug 2019 23:00:08 +0000

Planet Earth is heating up, with heatwaves increasing in frequency, intensity, and duration.1 In 2019, so far, all-time high temperature records have been toppled in multiple countries. An early and intense heatwave in Europe made June the hottest month on record for the continent with the average temperature 2°C above normal.2 France reported a new national temperature record of 45·9°C on June 28. On July 24–25, a second major heatwave in a month set new all-time highs on 2 consecutive days in Germany, Belgium, and the Netherlands.

[Comment] Political violence in Sudan: the need for a coordinated, locally led humanitarian health response

Thu, 15 Aug 2019 23:00:08 +0000

Since the fall of former Sudan President Omar al-Bashir's regime in April, 2019, the political and security situation in Sudan has been in flux. The Sudanese Transitional Military Council (TMC) and opposition groups signed a 3-year power-sharing agreement on July 4, 2019. Protesters have since voiced a mix of cautious optimism and scepticism, particularly about the role of the military in the transitional period.1 This is because until June 30, 2019, the TMC had violently responded to peaceful mass protests organised by the Forces for Freedom and Change (FFC), an umbrella organisation of opposition groups, prominently spearheaded by multiple medical professional bodies.

[Comment] Progress in beating the tobacco epidemic

Thu, 15 Aug 2019 23:00:08 +0000

Tobacco is a global health emergency.1,2 Tobacco use and second-hand smoke kill 8 million people each year and leave many more in poor health; estimates suggest tobacco could kill up to 1 billion people this century.3

[Comment] Testing the waters: a new test for hypotonic polyuria

Thu, 15 Aug 2019 23:00:08 +0000

Three disorders can cause water diuresis (hypotonic polyuria): primary polydipsia, central diabetes insipidus, and nephrogenic diabetes insipidus. These causes of hypotonic polyuria are difficult to differentiate, especially the partial forms of central diabetes insipidus from primary polydipsia.1 Yet this differentiation is crucial because the management for each disorder is quite different. For years, hypotonic polyuria was assessed with the water-deprivation test, with subsequent measurements of plasma vasopressin (the direct test) or urine osmolality (the indirect test).

[Comment] Interleukin-23 blockade: another breakthrough in the treatment of psoriasis

Thu, 15 Aug 2019 23:00:08 +0000

Before risankizumab's introduction, there were ten biologic therapies approved for psoriasis, with two more in development. Do we really need all of these expensive therapies for this disease? A close look at the data shows that we do not have any treatments that reliably achieve complete clearing as evidenced by psoriasis area and severity index (PASI) 100, and only the newest treatments achieve PASI 90 in high proportions of patients. Moreover, many treatments require frequent injections or are less effective in patients who have not had success with other therapies.

[Comment] Nerve transfers to restore upper limb function in tetraplegia

Thu, 15 Aug 2019 23:00:08 +0000

“For those who have nothing, a little is a lot.”1 As Sterling Bunnell, a pioneer of tetraplegic extremity reconstruction observed, small gains in function for people with spinal cord injury can equate to enormous gains in independence. People with mid-cervical spinal cord injury usually retain volitional movement at the shoulder and some control of their elbows and wrists. Hand opening and closing, a capacity that patients rate as more important to regain than walking or sexual function, is often lost.

[Editorial] The gender plight of humanitarian aid

Thu, 15 Aug 2019 23:00:08 +0000

World Humanitarian Day, which takes place on Aug 19 each year, celebrates the efforts of humanitarian aid workers operating in war-torn, resource deprived, or disease-affected settings to sustain human life. This year, special tribute is paid to the unsung heroes of humanitarian health—women. Whether they are at the forefront of an international crisis or operating within local communities, their long-lasting and stabilising impact makes them true peace keepers of humanitarian health.

[Editorial] Fear and uncertainty around Kashmir's future

Thu, 15 Aug 2019 23:00:08 +0000

Last week in a controversial move, India revoked the autonomous status of Jammu and Kashmir, allowing India greater authority over the state's affairs. The announcement fanned tension with Pakistan, which also claims the region and has fought India over it for more than seven decades. At least 28 000 Indian security forces have been deployed; in the capital city Srinagar, a lockdown has been implemented that suspended communication and internet links, and a strict curfew has been imposed. The militant presence raises serious concerns for the health, safety, and freedoms of the Kashmiri people.

[Editorial] Reaching critical mass on mass shootings

Thu, 15 Aug 2019 23:00:08 +0000

In just over a week, a spate of mass shootings devastated the USA: in Gilroy, CA, on July 28, 2019, three people were killed and 12 injured at a festival; in El Paso, TX, on Aug 3, 22 were killed and 24 injured at a shopping centre; and in downtown Dayton, OH, on Aug 4, another nine were killed and 27 were injured. It has left the country aghast, overwhelmed, and looking for answers to whether and how these killings can be prevented. Over 250 separate mass shootings have occurred in 2019. Although rare in the scope of gun violence, the seemingly unpredictable nature of these tragic events has begun to chisel away at the public's reluctance toward gun reform.

Medicare Wastes Billions on Newer Drugs

Thu, 15 Aug 2019 18:34:10 +0000

Medicare could have saved close to $17 billion from 2011-2017 by substituting 12 older drugs (racemic precursors) for newer single-enantiomer drugs, and beneficiaries could have saved more than $1 billion in out-of-pocket costs, researchers say.
Reuters Health Information

Air Pollution Can Damage Even Healthy Lungs

Thu, 15 Aug 2019 18:27:09 +0000

The more exposure people have to air pollution, especially ozone, the more lung damage they develop over time, a U.S. study suggests.
Reuters Health Information

'Punch in the Gut' as Scientists Find Micro Plastic in Arctic Ice

Thu, 15 Aug 2019 18:30:25 +0000

Tiny pieces of plastic have been found in ice cores drilled in the Arctic by a U.S.-led team of scientists, underscoring the threat the growing form of pollution poses to marine life in even the remotest waters on the planet.
Reuters Health Information

Virtual Reality Experiences Can Help Ease Severe Pain

Thu, 15 Aug 2019 18:20:44 +0000

Playing virtual reality games or relaxing in a virtual nature setting might help ease chronic pain, particularly when symptoms are severe, a new experiment suggests.
Reuters Health Information

Poorer Kids May Have Less Shade in Their Schoolyards

Thu, 15 Aug 2019 18:01:41 +0000

Elementary schools with the greatest proportions of poor children may have the least amount of shade in their schoolyards where kids spend their recess, a new U.S. study finds.
Reuters Health Information

Nine Hospital Nurses Pregnant at Same Time Have Given Birth

Thu, 15 Aug 2019 17:26:13 +0000

Nine labor and delivery nurses from Maine Medical Center in Portland who were all pregnant at the same time have all given birth to their babies.
Medscape Medical News

Использование электронных устройств может вызвать трудности с пониманием научной информации

Thu, 15 Aug 2019 18:56:41 +0000

Постоянный обмен текстовыми сообщениями с помощью смартфона или чтение на планшете отрицательно влияет на активность участков мозга, которые имеют решающее значение для обобщения информации из нескольких источников и переключения внимания. Эту связь установили исследователи из США.

AHA Scientific Statement on Critical Limb Ischemia

Thu, 15 Aug 2019 10:57:39 +0000

The American Heart Association reviews strengths and limitations of noninvasive and other imaging techniques used to diagnose critical limb ischemia in a new scientific statement.
Medscape Medical News

FDA Okays Pitolisant (Wakix) for Narcolepsy

Thu, 15 Aug 2019 11:40:43 +0000

The FDA has approved pitolisant, a first-in-class, nonscheduled treatment option with a novel mechanism of action for adults with narcolepsy.
FDA Approvals

Показ фотографий дерматологу поможет установить диагноз

Thu, 15 Aug 2019 16:28:42 +0000

Исследование, проведенное экспертами по кожным заболеваниям из Франции, показало, что все больше людей на приеме у дерматолога показывают фотографии поражений кожи. Это помогает врачам точнее представить процесс протекания заболевания и диагностировать состояние. Результаты исследования опубликованы в Journal of Allergy and Clinical Immunology.

Germline Genome Editing: International Commission Urges Caution

Thu, 15 Aug 2019 07:43:23 +0000

The International Commission on the Clinical Use of Human Germline Genome Editing met for the first time this week and urged caution.
Medscape Medical News

Фрукты и чай могут защищать от рака и заболеваний сердца

Thu, 15 Aug 2019 09:31:49 +0000

Новое исследование австралийских ученых из Университета Эдит Коуэн показало, что продукты, богатые флавоноидами, могут защищать от рака и сердечных заболеваний, особенно курящих и пьющих людей. К этим продуктам относятся яблоки и чай.

Early Gluten Intake Tied to Celiac Risk in Predisposed Children

Thu, 15 Aug 2019 01:06:05 +0000

Higher gluten intake during the first five years of life appears to be associated with an increased risk of celiac disease autoimmunity and celiac disease in genetically predisposed children, according to findings from the TEDDY study group.
Reuters Health Information

Brain Wave May Help Predict Psychosis

Wed, 14 Aug 2019 22:02:18 +0000

Deficits in amplitude of the auditory P300 event-related potential, a measure that can be detected by EEG, may be a prognostic biomarker of outcomes in patients with psychosis risk syndrome (PRS), researchers say.
Reuters Health Information

Course of Stargardt Disease Varies Between Siblings

Wed, 14 Aug 2019 21:57:54 +0000

Disease course is frequently discordant between siblings with Stargardt disease (STGD1) who carry the same ABCA4 gene variant, new findings show.
Reuters Health Information

Global Measles Cases Nearly Tripled Since Last Year, WHO Says

Wed, 14 Aug 2019 20:15:22 +0000

So far this year, the number of global measles cases is surging, reaching numbers that haven't been this high since 2006, according to WHO; measles vaccine uptake is also suboptimal.
Medscape Medical News

All Clinicians Have Unforgettable Patients: This One Has HIV

Wed, 14 Aug 2019 16:56:01 +0000

For Nelly Mugo, MD, seeing a woman in her care acquire HIV made her rethink how she and the whole system deliver healthcare.
Medscape Medical News

Trump Administration Hits Brakes on Law to Curb Unneeded Medicare CT Scans, MRIs

Wed, 14 Aug 2019 17:20:02 +0000

Critics worry the delays come at a steep cost: Medicare paying for millions of unnecessary exams and patients subject to radiation for no medical benefit.
Kaiser Health News

Tokyo Paralympics Marathon to Start Earlier Due to Heat Fears

Wed, 14 Aug 2019 16:42:13 +0000

The marathon race at the Tokyo 2020 Paralympics will start 30 minutes earlier than originally scheduled, as part of the organizers' efforts to tackle the heat threat to athletes and fans in the Japanese capital.
Reuters Health Information

Fewer Parents Smoke When Pediatricians Offer Tobacco Screening, Treatment

Wed, 14 Aug 2019 16:48:48 +0000

Parents who smoke may be more likely to quit when they receive tobacco screening and smoking cessation treatment from their child's pediatrician than when they don't get this support, a new study suggests.
Reuters Health Information

Teen Vaping Tied to Marijuana Use

Wed, 14 Aug 2019 16:45:32 +0000

Adolescents and young adults who have smoked e-cigarettes are more than three times more likely to move on to marijuana than youth who never try vaping, a research review study suggests.
Reuters Health Information

Type 1 Diabetes Often Misdiagnosed in Adults and Children

Wed, 14 Aug 2019 16:08:50 +0000

In adults it's commonly mistaken for type 2 diabetes, while children are often initially thought to have infections and progress to DKA before the correct diagnosis is made.
Medscape Medical News

FDA OKs 'Game Changer' Pretomanid for Highly Resistant TB

Wed, 14 Aug 2019 15:45:19 +0000

Pretomanid is only the third approved TB drug in 40 years. A pivotal study shows the oral drug regimen has a success rate of 89% and treatment takes 6 months instead of the current 2 years.
FDA Approvals

HsTroponin in ED Predicts Short-term CV Events

Wed, 14 Aug 2019 15:51:47 +0000

Use of the ESC 0/1-hour cardiac troponin algorithm predicts 30-day MACE with high safety and efficacy, but an extended algorithm that includes clinical judgment may better identify unstable angina.
Medscape Medical News

FDA Plans AdCom Meeting on Vascepa, Pushing CVD Approval

Wed, 14 Aug 2019 14:18:40 +0000

Vascepa, a high-dose purified form of eicosapentaenoic acid, showed significant benefit on CV events in the REDUCE-IT study, but any approval date for this indication will now be extended.
Medscape Medical News

Half of Patients Don't Tell Doctors Life-Threatening Details

Wed, 14 Aug 2019 14:23:40 +0000

Embarrassment and fear of judgment keep patients from disclosing domestic violence, survival of a sex assault, or struggles with depression or suicidal thoughts.
Medscape Medical News

Good Sleep Plus Limits on Screen Time Help With Impulse Control

Wed, 14 Aug 2019 14:47:38 +0000

The potential for positive change is high because few kids meet suggested sleep time and screen limits, a study found. Physicians can use the evidence to advise parents, the researchers say.
Medscape Medical News

Кальян более опасен, чем мы привыкли считать

Wed, 14 Aug 2019 19:09:40 +0000

Курение кальяна может нанести более значительный урон здоровью, чем обычное курение сигарет, выяснили американские ученые-химики, изучив выбросы во время стандартного сеанса кальянокурения.

Is It Ethical to Use Medical Data Derived From Evil Sources?

Wed, 14 Aug 2019 10:03:21 +0000

Some immoral experiments have produced valuable information.
Medscape Reader Polls

Frameless Brain Radiosurgery Maybe a Boon for Patients, Surgeons

Wed, 14 Aug 2019 10:23:45 +0000

Early experience with the Gamma Knife Icon — a novel form of frameless stereotactic radiosurgery — is more convenient for patients and improves workflow for neurosurgeons.
Medscape Medical News

Estrogen Patch a Boon for Schizophrenia in Women?

Wed, 14 Aug 2019 09:44:15 +0000

Adjunctive estrogen patches significantly improve positive and negative symptoms of schizophrenia in premenopausal women, new research suggests.
Medscape Medical News

California Surprise-Billing Law Lowers In-Network Payments: Study

Wed, 14 Aug 2019 07:51:52 +0000

Based on interviews with stakeholders, the study shows that government intervention has altered the balance of power between physicians and health plans.
Medscape Medical News

Люди старше 55 лет не должны ждать выхода на пенсию, чтобы уделять время здоровью

Wed, 14 Aug 2019 14:03:24 +0000

Согласно новому отчету Университета Восточной Англии, нехватка времени из-за работы и недостаток мотивации к физической активности приводят к тому, что к выходу на пенсию состояние многих людей ухудшается. Однако людям зрелого возраста следует поддерживать уровень физической активности, если они хотят на пенсии чувствовать себя хорошо.

«Нельзя сводить проблему только к обеспечению лекарствами льготников»

Wed, 14 Aug 2019 09:01:22 +0000

Половина россиян имеют сложности с покупкой лекарств из-за отсутствия денег, две трети сталкивались с некачественными препаратами и 90% считают, что систему обеспечения лекарствами надо менять. Таковы итоги исследования «Качество и доступность лекарственных средств-2019». России пора переходить от льготного обеспечения к лекарственному страхованию для всех, считают эксперты.

Antidiabetic-Medication Prescriptions Change Little Following CV Events

Tue, 13 Aug 2019 22:14:01 +0000

The prescription of glucose-lowering medications in patients with type 2 diabetes changes little after a cardiovascular event, the DATAFILE study shows.
Reuters Health Information

Superbug E. Coli Strains in Healthy Women Raise Risk of Resistant UTIs

Tue, 13 Aug 2019 22:23:03 +0000

Fluoroquinolone-resistant (FQR) strains of Escherichia coli may persist in the gut of healthy women and subsequently invade the urinary system, researchers say.
Reuters Health Information

Naltrexone Seems Effective for Opioid Use Disorder in Pregnancy

Tue, 13 Aug 2019 22:27:23 +0000

Naltrexone may be effective for treating opioid use disorder (OUD) in pregnant women who choose to completely detoxify off opioid drugs, researchers report.
Reuters Health Information

Steady Beeping of Trivial Alarms Desensitizes ED Staff

Tue, 13 Aug 2019 22:06:35 +0000

Walk into any emergency room in the U.S. and you'll hear a regular din of beeping alarms going off from machines connected to patients. But a new study found only a tiny fraction of the alarms signals a condition important enough to require a change in the patient's care.
Reuters Health Information

Health Organizations Decry New 'Public Charge' Rule

Tue, 13 Aug 2019 19:36:29 +0000

The Trump administration policy will make legal immigrants sicker and potentially drive up costs for all Americans, they said.
Medscape Medical News

Acupuncture May Improve Leg Pain in Chronic Discogenic Sciatica

Tue, 13 Aug 2019 17:51:12 +0000

Acupuncture can relieve leg pain in patients with chronic discogenic sciatica, a small sham-controlled trial suggests.
Reuters Health Information

Evolus Says Launch of Its Botox Rival Ahead of Its Expectations

Tue, 13 Aug 2019 18:11:00 +0000

Evolus Inc on Monday reported revenue of $2.3 million from early sales of its newly launched rival to Allergan Plc's Botox, ahead of its own expectations.
Reuters Health Information

Genotyping Panel Accurately Identifies Biomarkers for Solid Cancers in Plasma

Tue, 13 Aug 2019 18:26:58 +0000

A highly sensitive cell-free DNA (cfDNA) sequencing-based method allows simultaneous determination of microsatellite instability (MSI) status and genomic biomarkers for solid cancers in plasma, researchers report.
Reuters Health Information

Hepatitis A Races Across the Country

Tue, 13 Aug 2019 16:51:19 +0000

The virus continues its march across the nation, with Florida and Philadelphia the latest areas to declare public health emergencies.
Kaiser Health News

Residency Bullying: Trainer on Trainee Harassment Common

Tue, 13 Aug 2019 16:39:59 +0000

In a national survey of internal medicine residents, approximately 14% reported experiencing bullying during their training but fewer than one third sought help.
Medscape Medical News

Surprise Medical Bills Are Increasingly Common, Study Finds

Tue, 13 Aug 2019 15:11:53 +0000

The percentage of emergency department visits at an in-network hospital for which patients received bills from out-of-network providers increased 11% between 2010 and 2016.
Medscape Medical News

Baffling Rift Between Patients With HIV and the Right Statin

Tue, 13 Aug 2019 15:23:17 +0000

The Framingham score, used to evaluate risk for a cardiovascular event, is low-balling the threat in patients with HIV. And conflicting results on the success of statins is perplexing specialists.
Medscape Medical News

PE Admissions Up, but Short-term Mortality Down

Tue, 13 Aug 2019 14:27:41 +0000

Hospital admissions for pulmonary embolization have risen during the past 15 years, but short-term mortality rates have dropped.
Medscape Medical News

Decision Aid Improves Management of Febrile Neutropenia

Tue, 13 Aug 2019 13:08:14 +0000

Clinical decision aid helps improve adherence to best practice guidelines for febrile neutropenia management in oncology patients.
Medscape Medical News

Kaiser Permanente's California Workers Vote to Authorize Strike

Tue, 13 Aug 2019 06:55:22 +0000

The strike would start in October and would be the nation's largest since 1997.
Medscape Medical News

Низкоуглеводная диета полезна при диабете 2-го типа

Tue, 13 Aug 2019 18:36:07 +0000

Сокращение углеводов наряду с увеличением доли белков и жиров улучшает способность пациентов с диабетом 2-го типа регулировать уровень сахара в крови, свидетельствует датское исследование.

'Fat Suit' May Uncover Medical Student Biases Against Obesity

Tue, 13 Aug 2019 09:54:02 +0000

Obesity simulation suits, worn by actors who play fake patients during training exercises, may help teach medical students about their own anti-fat prejudices, suggests a small study in Germany.
Reuters Health Information

Common ADHD Medication May Affect Brain Development

Tue, 13 Aug 2019 10:01:36 +0000

Treatment with methylphenidate appears to affect the development of the brain's signal-carrying white matter in boys with ADHD, new research suggests.
Medscape Medical News

Physically Active People Have Lower Colon Cancer Risk

Tue, 13 Aug 2019 09:40:36 +0000

People who exercise regularly may be less likely to develop precursors to colorectal cancers, a research review suggests.
Reuters Health Information

Amgen Wins U.S. Patent Battle on Arthritis Drug Enbrel, Thwarting Novartis

Tue, 13 Aug 2019 09:35:52 +0000

A U.S. judge on Friday said two patents relating to Amgen Inc's blockbuster rheumatoid arthritis drug Enbrel (etanercept) were valid, denying a challenge by Novartis AG, which is seeking to launch a copycat version.
Reuters Health Information

Duodenal Mucosal Resurfacing Lowers HbA1c in Early Study

Tue, 13 Aug 2019 09:38:27 +0000

The findings add 'to the growing body of evidence that the GI tract, and particularly the duodenum, is an important target for interventions to treat [type 2 diabetes],' say researchers.
Medscape Medical News

Kaiser Permanente's California Workers Vote to Authorize Strike

Tue, 13 Aug 2019 06:55:22 +0000

Kaiser Permanente's California Workers Vote to Authorize Strike
Medscape Medical News

Менингит: в зоне риска все без исключения

Tue, 13 Aug 2019 10:45:23 +0000

Бактериальный менингит, считающийся вакциноконтролируемой инфекцией, продолжает убивать россиян.

У детей, взрослеющих позже сверстников, может быть выше риск переломов костей

Tue, 13 Aug 2019 09:05:21 +0000

Задержка полового созревания может быть связана с повышенным риском переломов и остеопороза в зрелом возрасте, как установили в ходе исследования ученые Бристольского университета.

Point-of-care Urinary Biomarker Predicts Poor Outcomes in Combat Casualties

Tue, 13 Aug 2019 00:59:25 +0000

A point-of-care dipstick test for urine neutrophil gelatinase-associated lipocalin (NGAL) is useful for risk prediction in critically injured soldiers, researchers report.
Reuters Health Information

Superior Hypogastric Plexus Neurolysis May Help Some With Cancer-Related Pelvic Pain

Tue, 13 Aug 2019 01:05:16 +0000

Superior hypogastric plexus neurolysis (SHPN) appears to offer some relief for cancer-related pelvic pain, researchers report.
Reuters Health Information

Waterjet Ablation Effective for Treating Benign Prostatic Obstruction

Tue, 13 Aug 2019 01:08:19 +0000

Waterjet ablation appears promising for relieving benign prostatic obstruction in men with small- to medium-sized glands, according to results from the French Aquablation Clinical Registry.
Reuters Health Information

Lack of Corpus Luteum May Impair Cardiovascular System in IVF Pregnancies

Tue, 13 Aug 2019 01:21:36 +0000

A corpus luteum (CL) plays a "critical role" in the transformation of a woman's cardiovascular system early in pregnancy, and lack of a CL common in IVF pregnancies - may raise the risk of pre-eclampsia, researchers say.
Reuters Health Information

Late Puberty May Lead to Weaker Bones

Tue, 13 Aug 2019 01:16:40 +0000

Teens who hit puberty late may end up with weaker bones, a new study finds.
Reuters Health Information

Mediterranean Diet Tied to Lower Risk of Gestational Diabetes

Tue, 13 Aug 2019 01:13:34 +0000

Pregnant women at high risk for gestational diabetes may be less likely to experience this complication when they switch to a Mediterranean diet, a recent experiment suggests.
Reuters Health Information

Experimental Ebola Drugs Reduce Mortality in Early Results

Mon, 12 Aug 2019 18:51:18 +0000

Regeneron EB-3 and monoclonal antibody 114 will be made available to all patients with Ebola virus disease in the region, regardless of whether they were enrolled in the trial.
Medscape Medical News

Smart Home Tech Makes Inroads Into China's Emerging Elderly Care Market

Mon, 12 Aug 2019 17:21:43 +0000

Charging elderly clients just 1 yuan or about 15 cents a day, little-known Lanchuang Network Technology Corp has embarked on one of the most ambitious undertakings in aged care by a private sector firm in China.
Reuters Health Information

Cardiac Evaluation Valuable in Children With a Close Family History of Sudden Death

Mon, 12 Aug 2019 17:28:26 +0000

A new study provides "quantitative justification" for guidelines that recommend cardiac evaluation in close relatives of someone who dies suddenly at a young age, although findings of uncertain significance increase the challenge to clinical management, the researchers say.
Reuters Health Information

Cloud-Based Telemedicine Platform May Cut Unnecessary Ophthalmology Referrals

Mon, 12 Aug 2019 17:40:11 +0000

Implementation of a cloud-based telemedicine platform can reduce unnecessary ophthalmology referrals by more than half, according to a retrospective study from the U.K.
Reuters Health Information

Little Progress Seen in Diabetes Care in Past 15 Years

Mon, 12 Aug 2019 12:59:24 +0000

Gaps in diabetes diagnosis, linkage to care, and achievement of treatment targets essentially remained the same from 2005 through 2016 despite care advances.
Medscape Medical News

NSAIDs May Increase CVD Risk in OA

Mon, 12 Aug 2019 13:37:54 +0000

Nonsteroidal anti-inflammatory drugs may play a major role in cardiovascular disease risk associated with osteoarthritis and should be avoided if possible, a longitudinal study suggests.
Medscape Medical News

No-Deal Brexit Could Deepen Europe's Shortage of Medicines - Experts

Mon, 12 Aug 2019 13:12:19 +0000

As the Oct. 31 deadline for Britain to leave the European Union approaches, health professionals are warning that shortages of some medicines could worsen in Europe in the event of a no-deal Brexit.
Reuters Health Information

New Trump Rule Would Target Legal Immigrants Who Get Public Assistance

Mon, 12 Aug 2019 13:16:29 +0000

U.S. President Donald Trump's administration unveiled a sweeping rule on Monday that would limit legal immigration by denying visas and permanent residency to hundreds of thousands of people for being too poor.
Reuters Health Information

Труднее не столько что-то вспомнить, сколько вовремя отфильтровать неуместные воспоминания

Mon, 12 Aug 2019 19:04:01 +0000

Исследователи из американского Университета Джонса Хопкинса установили, что некоторые проблемы с памятью связаны не столько с самой памятью, сколько с поиском правильной информации в нужное время для решения той или иной задачи.

The 'Knitting Lady' Is a Surgeon and She's Paying Attention

Mon, 12 Aug 2019 11:36:50 +0000

A breast surgeon was scolded by a presenter at a medical conference for knitting during his talk and not paying good attention. But she, and many other healthcare professionals, say they can't pay attention during lectures unless they keep their hands busy. Science and grannies support their claim.
Medscape Medical News

New Data on Antidepressants and Stroke Risk

Mon, 12 Aug 2019 07:02:46 +0000

With mixed results in previous resesants that strongly vs weakly inhibit serotonin.
Medscape Medical News

Deeper Dive Into CTE, Dementia in Football Reveals New Players

Mon, 12 Aug 2019 07:21:35 +0000

For the first time, researchers implicate white matter changes and atherosclerosis in a study examining multiple factors contributing to dementia risk in former football players with CTE.
Medscape Medical News

Прием антибиотиков в младенчестве повышает риск возникновения детской астмы

Mon, 12 Aug 2019 13:19:00 +0000

Астма в детском возрасте может быть связана с применением антибиотиков у младенцев до года, как обнаружили американские исследователи.

Ожоги от покрытия дорог и тротуаров - растущая проблема

Mon, 12 Aug 2019 09:25:51 +0000

Врачи из Университета Невады предупреждают об одной из опасностей, возникающих в период летней жары, а именно об ожогах от контакта с раскаленным дорожным покрытием. Их недавнее исследование показывает, что в жару люди нередко обращаются в больницу с серьезными ожогами, вызванными раскаленным покрытием дорог и тротуаров.

LVAD Patients More Active, Fit Than Counterparts With Heart Failure

Sat, 10 Aug 2019 16:13:10 +0000

Patients with left ventricular assist devices (LVAD) are more physically active than matched patients with advanced chronic heart failure (CHF), and have higher peak oxygen consumption (VO2 peak), according to new findings.
Reuters Health Information

Diabetes Risk Tied to Common Chemicals, Curbed by Healthy Habits

Sat, 10 Aug 2019 16:01:50 +0000

Chemicals in everything from food wrappers to clothing and furniture are associated with an increased risk of diabetes, but much of this added risk is reduced with good eating and exercise habits, a study suggests.
Reuters Health Information

Dense Breast Notification Laws Not Leading to More Screening Ultrasounds

Sat, 10 Aug 2019 16:01:46 +0000

State laws requiring women with dense breasts to be told about the benefits of further imaging after mammography may not lead more women to get extra screening, a U.S. study suggests.
Reuters Health Information

FDA Tells Four Firms to Stop Selling Flavored E-Cigarette, Hookah Products

Sat, 10 Aug 2019 10:30:19 +0000

The U.S. Food and Drug Administration has told four companies to remove 44 of their flavored e-liquid and hookah tobacco products that do not have the required approval for sale in the U.S., the agency said on Thursday.
Reuters Health Information

More Evidence Preemies May Grow Up to Be Unlucky in Love

Sat, 10 Aug 2019 10:44:32 +0000

Adults who were underweight or premature babies may be less likely to have romantic or sexual relations or become parents than their counterparts who were full-term infants, a research review suggests.
Reuters Health Information

ESRD: Extreme Heat Tied to Risk for Hospitalization, Death

Fri, 09 Aug 2019 19:17:38 +0000

For vulnerable populations, the impact of climate change can be a lot more immediate than for the general population.
Medscape Medical News

Most Residents Say Work/Life Balance Is No. 1 in Job Hunt

Fri, 09 Aug 2019 17:59:59 +0000

They list it as their biggest challenge in training in a Medscape lifestyle survey. Bullying and sexual harassment persist.
Medscape Medical News

Dealing With the Lingering Effects of a Mass Shooting

Fri, 09 Aug 2019 16:42:27 +0000

The director of the San Bernardino (Calif.) County Department of Behavioral Health has broadened the agency's focus to caring for people struggling with psychological trauma from mass shootings.
Kaiser Health News

New Wearable Device Helps Detect Dyskinesia in Parkinson's

Fri, 09 Aug 2019 15:14:52 +0000

The device can help physicians identify patients with motor fluctuations without spending long periods of time at the clinic, a new study suggests.
Medscape Medical News

FDA Investigating Reports of Neurologic Risks Tied to Vaping

Fri, 09 Aug 2019 13:53:54 +0000

The FDA is trying to determine if there is a direct link between e-cigarettes and a risk of seizure or other neurologic symptoms; the agency is encouraging providers and the public to report cases.
Medscape Medical News

More Nuts Improve Men's Orgasmic Function, Sexual Desire

Fri, 09 Aug 2019 14:18:51 +0000

Adding a mix of nuts to a typical Western diet improves orgasmic function and sexual desire in healthy men aged 18 to 35 years, but no change in erectile dysfunction and intercourse satisfaction was found.
Medscape Medical News

Reducing Post-Tonsillectomy Opioids May Be Feasible in Kids

Fri, 09 Aug 2019 13:10:35 +0000

More than half of children receive opioids after tonsillectomy, but this prescription does not seem to protect against complications such as pain or bleeding, a study found.
Medscape Medical News

FDA Calls Out Drug Company for 'Manipulated' Data

Fri, 09 Aug 2019 13:44:27 +0000

AveXis knowingly submitted manipulated data in its application for Zolgensma, the first gene therapy approved for spinal muscular atrophy, the agency says; the product will remain on market for now.
Medscape Medical News

Sweet News: Dark Chocolate Tied to Lower Depression Risk

Fri, 09 Aug 2019 09:13:16 +0000

Observational data provide some evidence that consumption of dark chocolate may reduce the likelihood of clinically relevant depressive symptoms.
Medscape Medical News

Риск диабета от воздействия химических веществ помогут снизить диета и упражнения

Fri, 09 Aug 2019 13:17:10 +0000

Некоторые химические вещества, содержащиеся в пищевых упаковках и иногда в других товарах, связаны с повышенным риском развития диабета. Но значительную часть этого дополнительного риска можно снизить изменениями в диете и физическим упражнениям. К такому выводу пришли американские ученые, которые опубликовали свои результаты в журнале Diabetes Care.

Избегать кофе при мигрени необязательно. Главное – знать меру

Fri, 09 Aug 2019 13:20:23 +0000

У людей с эпизодической мигренью 3 или более чашек кофе с кофеином в день могут спровоцировать головную боль в тот же или на следующий день, согласно новому исследованию Медицинского центра Бет Исраэль Диаконисс, Бригама и Женской больницы и Гарвардской школы общественного здоровья им. Т.Х. Чана. Его результаты опубликованы в American Journal of Medicine.

DC Physician Indicted for Almost $13M in Medicare Fraud

Fri, 09 Aug 2019 06:32:12 +0000

He allegedly submitted claims for procedures that were medically unnecessary, not provided, or both.
Medscape Medical News

Прививки не повышают риск развития рассеянного склероза

Fri, 09 Aug 2019 08:41:31 +0000

Новое крупное немецкое исследование показало, что прививки не являются фактором риска рассеянного склероза. Результаты, опубликованные в журнале Neurology, наоборот, показывают устойчивую связь между более высокими показателями вакцинации и снижением вероятности развития этого расстройства.

[Series] Genomic medicine for undiagnosed diseases

Thu, 08 Aug 2019 23:00:09 +0000

One of the primary goals of genomic medicine is to improve diagnosis through identification of genomic conditions, which could improve clinical management, prevent complications, and promote health. We explore how genomic medicine is being used to obtain molecular diagnoses for patients with previously undiagnosed diseases in prenatal, paediatric, and adult clinical settings. We focus on the role of clinical genomic sequencing (exome and genome) in aiding patients with conditions that are undiagnosed even after extensive clinical evaluation and testing.

[Series] Pharmacogenomics

Thu, 08 Aug 2019 23:00:09 +0000

Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy—the topic addressed here—is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, and ongoing efforts to implement pharmacogenetics in clinical practice.

[Series] Opportunities, resources, and techniques for implementing genomics in clinical care

Thu, 08 Aug 2019 23:00:09 +0000

Advances in technologies for assessing genomic variation and an increasing understanding of the effects of genomic variants on health and disease are driving the transition of genomics from the research laboratory into clinical care. Genomic medicine, or the use of an individual's genomic information as part of their clinical care, is increasingly gaining acceptance in routine practice, including in assessing disease risk in individuals and their families, diagnosing rare and undiagnosed diseases, and improving drug safety and efficacy.

[Clinical Picture] Dyspnoea, clubbing, cirrhosis, and bubbles in both sides of the heart suggests hepatopulmonary syndrome

Thu, 08 Aug 2019 23:00:09 +0000

A 48-year-old Chinese man with a 12-month history of increasing shortness of breath on exertion was admitted to our hospital. He was a heavy smoker and had been diagnosed with Child-Pugh class C alcoholic cirrhosis 5 years earlier, which was complicated by oesophageal varices that haemorrhaged 1 month before this admission; he had an urgent gastroscopy and the varices were banded.

[Articles] Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis

Thu, 08 Aug 2019 23:00:09 +0000

This updated systematic review and meta-analysis includes data from 60 million individuals and up to 8 years of post-vaccination follow-up. Our results show compelling evidence of the substantial impact of HPV vaccination programmes on HPV infections and CIN2+ among girls and women, and on anogenital warts diagnoses among girls, women, boys, and men. Additionally, programmes with multi-cohort vaccination and high vaccination coverage had a greater direct impact and herd effects.

[Articles] Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study

Thu, 08 Aug 2019 23:00:09 +0000

Preoperative urinary DKK3 is an independent predictor for postoperative AKI and for subsequent loss of kidney function. Urinary DKK3 might aid in the identification of patients in whom preventive treatment strategies are effective.

[Articles] Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial

Thu, 08 Aug 2019 23:00:09 +0000

Pexidartinib is the first systemic therapy to show a robust tumour response in TGCT with improved patient symptoms and functional outcomes; mixed or cholestatic hepatotoxicity is an identified risk. Pexidartinib could be considered as a potential treatment for TGCT associated with severe morbidity or functional limitations in cases not amenable to improvement with surgery.

[Articles] 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial

Thu, 08 Aug 2019 23:00:09 +0000

A 2-cm excision margin was safe for patients with thick (>2 mm) localised cutaneous melanoma at a follow-up of median 19·6 years. These findings support the use of 2-cm excision margins in current clinical practice.

[Department of Error] Department of Error

Thu, 08 Aug 2019 23:00:09 +0000

[Department of Error] Department of Error

Thu, 08 Aug 2019 23:00:09 +0000

Moazen B, Assari S, Neuhann F, Stöver H. The guidelines on infection control in prisons need revising. Lancet 2019; 394: 301–02—In this Correspondence, the second sentence of the first paragraph should have read “The proportion of prisoners in the world with HIV has been estimated at 3·8%, hepatitis C virus (HCV) at 15·1%, hepatitis B virus (HBV) at 4·8%, and tuberculosis at 2·8%.” This correction has been made to the online version as of July 30, 2019.

[Correspondence] Fiscal policies and global public health

Thu, 08 Aug 2019 23:00:09 +0000

In his Correspondence on fiscal policies and the gilets jaunes, Franco Sassi1 argued that policy makers should consider using hypothecation (earmarking) to increase public acceptance of taxes levied on unhealthy products such as tobacco, alcohol, and sugar-sweetened beverages.

[Correspondence] Yellow vests protests: facial injuries from rubber bullets

Thu, 08 Aug 2019 23:00:09 +0000

Since November, 2018, France has been facing violent contestation with the national so-called yellow vests protests, resulting in about 4000 casualties.1 We managed 21 patients who presented with face and eye injuries caused by rubber bullets from non-lethal hand-held weapons (NLHHWs). Because of the steady increase in the overall number and violence of protests worldwide,2 one might expect a rise in injuries caused by NLHHWs.

[Correspondence] The harsh effects of sanctions on Iranian health

Thu, 08 Aug 2019 23:00:09 +0000

Iran has been under different rounds of economic sanctions since 1980. In July, 2015, the UN Security Council, Germany, and the EU were successful in forming an agreement with Iran, called the Joint Comprehensive Plan of Action (JCPOA), that relieved some of these sanctions. Even though the International Atomic Energy Agency verified that Iran was abiding by the provisions of the deal, US President Donald Trump announced the withdrawal of the USA from the JCPOA in May, 2018. A new round of US-issued sanctions has been imposed on Iran since November, 2018, to stop Iran's oil sales.

[Correspondence] Ending diabetes in Mexico

Thu, 08 Aug 2019 23:00:08 +0000

Diabetes leads to thousands of deaths and billion-dollar spending even though it is a predictable lifestyle disease.

[Correspondence] HIV in South Africa

Thu, 08 Aug 2019 23:00:08 +0000

South Africa is home to the largest HIV seropositive population in the world, with 7·2 million individuals.1 Since the country's first case of HIV in 1982, South Africa has come a long way to reduce HIV/AIDS-related rates of infection, morbidity, and mortality. Some responses to the epidemic fostered improvement, whereas others exacerbated the crisis. As a dramatic lesson, the denialist line of Thabo Mbeki should be mentioned. Outlawing the use of antiretroviral therapy is estimated to have led to 330 000 AIDS-related deaths.

[Correspondence] Alzheimer's disease and neurodegenerative diseases in France

Thu, 08 Aug 2019 23:00:08 +0000

On May 30, 2018, French Minister of Solidarity and Health Agnès Buzyn unveiled her policy roadmap for the elderly, entitled Great Age and Autonomy.1 In fact, in 2050, one in three individuals in France will be older than 60 years.2 However, to guarantee healthy ageing and long lives to France's elderly people, policy pushes need to be made towards the prevention of Alzheimer's disease and other neurodegenerative diseases.

[Correspondence] Road safety in Sudan

Thu, 08 Aug 2019 23:00:08 +0000

In the field of global health and beyond, a great deal of emphasis is often placed on treating and preventing disease, while the determinants of health often take a back seat. Road safety has become a pillar of healthy populations and a priority for sustainable cities, yet many countries continue to grapple with high numbers of fatalities and injuries from traffic accidents. Developing countries, specifically, must treat road safety as a public health priority and develop policies that can sharply decrease the risk of avoidable deaths on the road.

[Correspondence] Preparing the next generation of global public health experts

Thu, 08 Aug 2019 23:00:08 +0000

Students in SciencesPo's Global Health Masters course have extracted health data from the Institute for Health Metrics and Evaluation's Global Burden of Disease database to produce policy papers to address diabetes in Mexico, Alzheimer's disease in France, HIV in South Africa, and traffic accidents in Sudan. The students evaluated the measures taken by governments and ministers of health, and in this issue of The Lancet, they propose ways to strengthen the correction of these burdens of disease, while not omitting the interpectoral aspects of public policies to be put in place.

[Correspondence] Science and literature: complementary, not contradictory

Thu, 08 Aug 2019 23:00:08 +0000

On introducing myself as an undergraduate biochemist to those without scientific backgrounds, I am almost invariably met by an uncertain look and a change of topic. I find myself far more likely to have a productive conversation about my school A-level qualification in English literature than about the university degree I have spent the last 3 years on. To be what most of general society recognises as cultured is to be well read, historically knowledgable, and politically engaged; a scientific background rarely factors into this concept.

[Perspectives] The remaking of Shakespeare

Thu, 08 Aug 2019 23:00:08 +0000

Does anyone really enjoy Shakespeare? There can be a sense of weary obligation around him: he comes to us as set texts to be studied for exams, or as cultural experiences to be swallowed like medicine, and shrouded in an aura of genius that suggests any lack of delight or understanding must be a failure on your part. But as Emma Smith points out in This is Shakespeare, a collection of essays on 20 of the plays, this hasn't always been the case: “Shakespeare wasn't always ‘Shakespeare’.” In his own time, he was just another playwright; many audience members would not even have known they were watching “Shakespeare”, only the names of the play and the company performing it.

[Perspectives] Teri Manolio: steering genomics into clinical medicine

Thu, 08 Aug 2019 23:00:08 +0000

After almost three decades of research in genomics, Teri Manolio, Director of Genomic Medicine at the National Human Genome Research Institute (NHGRI), Bethesda, MD, USA, believes we have reached a key moment when genomics is beginning to have an impact in clinical medicine. “The area of pharmacogenomics is a good example of clinical applicability as we can help guide clinical decision making according to drug reactions that are genetically mediated”, she says. Manolio, who is a lead author of a new Lancet genomic medicine Series, sees the emerging role of genomics in clinical medicine as a natural progression in aiding clinical decision making.

[Perspectives] The “nice work” of transforming the health workforce

Thu, 08 Aug 2019 23:00:08 +0000

At a medical conference, a friend apologised for missing my session on inclusion and equity in health care. He had attended a talk on sepsis instead, choosing this “life and death” topic over what seemed to him a more niche issue. “But I really think you're doing such nice work”, he said.

[World Report] GP at hand: a digital revolution for health care provision?

Thu, 08 Aug 2019 23:00:08 +0000

Babylon's health app has certainly changed the way its users consume health care. But a chorus of supporters and detractors struggle to agree on whether it is for better or worse. Talha Burki reports.

[Comment] Genomic medicine: time for health-care transformation

Thu, 08 Aug 2019 23:00:08 +0000

Genomic medicine—the use of genetic information to inform medical care or predict risk of disease—is beginning to transform health care. The first human genome cost about US$3 billion to sequence.1,2 A whole human genome can now be sequenced for under $1000, and for even less it is possible to read targeted parts of the genome (panels) or the protein coding part (the exome). The timely and comprehensive Lancet Series on genomic medicine3–7 reviews the opportunities, challenges, resources, and techniques for application of next generation sequencing in health care.

[Comment] Introducing The Penumbra

Thu, 08 Aug 2019 23:00:08 +0000

There are few topics that cause as much discomfort as inequities, particularly those related to race, gender, and other social identifiers. As a frequent lecturer, I've found the issue of how inequities shape one's experience in the health-care system, whether as a patient or in the workforce, often elicits avoidance, dismissiveness, defensiveness, or even anger. Health-care curricula typically neglect discussion of structural racism or sexism, and relegate race, sex, gender, gender identity, sexual orientation, and disability to the vague and misplaced category of risk factors.

[Comment] The Lancet Group's commitments to gender equity and diversity

Thu, 08 Aug 2019 23:00:08 +0000

6 months ago, The Lancet published a theme issue on women in science, medicine, and global health (#LancetWomen) that raised concerns about systemic gender bias impeding the advancement of, and equity for, women within these fields. We called for urgent action to create institutional change.1 Whether with a social justice or a business lens, the case for gender equity and diversity is clear: teams that are diverse in terms of gender, ethnicity, and social background produce better health science, are more highly cited, generate a broader range of ideas and innovations, and better represent society.

[Comment] A biomarker able to predict acute kidney injury before it occurs?

Thu, 08 Aug 2019 23:00:08 +0000

The incidence of acute kidney injury (AKI) after cardiac surgery appears to have increased,1 especially among older patients with increasing comorbidities.2 Although some patients who undergo cardiac surgery develop mild AKI and recover apparently well, others have catastrophic AKI requiring renal replacement therapy. Not uncommonly, patients follow a protracted clinical course beyond the usual 7-day timespan and maintain renal dysfunction for up to 90 days (acute kidney disease) or it evolves into chronic kidney disease (CKD) or end-stage kidney failure.

[Comment] Systemic treatment of tenosynovial giant cell tumours in context

Thu, 08 Aug 2019 23:00:08 +0000

Tenosynovial giant cell tumours (TGCTs) are a rare family of proliferative and inflammatory tumours, mostly affecting young adults. These tumours are benign lesions arising from the synovium, bursae, or tendon sheaths, and present either as a single nodule (localised type) or as multiple nodules (diffuse type). Previously, these tumour types were classified as pigmented villonodular synovitis or giant cell tumour of the tendon sheath. In the most recent version of the WHO classification of tumours of soft tissue and bone, it has been suggested that TGCT replaces both designations.

[Comment] Appropriate excision margins for cutaneous melanomas

Thu, 08 Aug 2019 23:00:07 +0000

In an era when attempts to better understand the pathophysiology and treatment of melanoma are focused on complex genomics and proteomics, it is remarkable that fundamentally simple questions about surgical excision margins remain unanswered. Often overlooked is the important fact that most patients who present with a primary cutaneous melanoma can be cured by surgery alone. The extent of that surgery must clearly be sufficient to maximise the chance of cure, while minimising patient morbidity and health-care costs associated with the reconstruction of large excision defects.

[Editorial] Bolsonaro ameaça a sobrevivência da população Indígena no Brasil

Thu, 08 Aug 2019 23:00:07 +0000

O desmatamento da floresta tropical do Brasil tem acelerado em ritmo alarmante, ameaçando a população Indígena, que depende inteiramente da terra para sobreviver, e também enfraquecendo o papel crucial da floresta tropical de estabilizar o clima global. De acordo com os dados de satélite mais recentes, de 1 a 25 de Julho, 1864 km2 de floresta amazônica foi destruída, mais do que o triplo de todo mês de Julho de 2018.

[Editorial] Bolsonaro threatens survival of Brazil's Indigenous population

Thu, 08 Aug 2019 23:00:07 +0000

Deforestation in the Brazilian rainforest has accelerated at an alarming pace, imperilling the country's Indigenous people, who depend entirely on the land for survival, and also weakening the rainforest's crucial role in stabilising the global climate. According to the most recent satellite data, from July 1 to 25, 2019, 1864 km2 of Amazon forest were destroyed, more than triple that for all of July, 2018.

[Editorial] A call for paediatricians to tackle racism

Thu, 08 Aug 2019 23:00:07 +0000

A very important first policy document, released by the American Academy of Pediatrics (AAP) on July 29, addresses one of the most neglected social determinants of child and adolescent health—racism. Although some progress has been made to recognise racial inequities, the potential for paediatricians and child health workers to disrupt lifelong and intergenerational disadvantages detrimental to health and development has so far not been realised in a systematic way. This policy document is a much needed wake-up call and guide at a time when in many countries the political climate and cultural environment threatens to reverse the little progress that has been made to date.

[Editorial] Improving occupational health in China

Thu, 08 Aug 2019 23:00:07 +0000

China has the largest working population in the world—about 776 million in 2018, and most workers spend half their lives working. The Chinese Government prioritised occupational health in the action plan of Healthy China 2030 as one of its 15 major health projects. Last week, the National Health Commission (NHC) announced the latest official data on the country's occupational health status and unveiled China's strategy to address the challenges in occupational health. More than 975 000 cases of occupational illness occurred in 2018, and 90% of reported occupational diseases were pneumoconiosis.

Cortisol in Hair May Help Diagnose Teen Depression

Thu, 08 Aug 2019 18:30:15 +0000

Levels of the stress hormone cortisol in hair is a potential diagnostic biomarker for depressive symptoms and other psychiatric conditions in teens, new research suggests.
Medscape Medical News

Endometriosis Linked to Adverse Pregnancy Outcomes

Thu, 08 Aug 2019 17:00:00 +0000

Endometriosis was associated with increased risk for spontaneous abortion, ectopic pregnancy, and preeclampsia, a study found.
Medscape Medical News

Physician Groups Forge Action Plan Against Gun Violence

Thu, 08 Aug 2019 17:09:11 +0000

They call for criminal background checks for most firearm purchases and allowing physicians to talk about gun ownership among a slate of proposed crackdowns. An expert says real change will take more.
Medscape Medical News

What's Behind a Cluster of Vaping-Related Severe Lung Disease?

Thu, 08 Aug 2019 17:25:51 +0000

With 15 confirmed cases, healthcare providers should ask about recent e-cigarette use when diagnosing unexplained respiratory illness, experts stress.
Medscape Medical News

Telephone Counseling Aids Vets With Diabetes and Depression

Thu, 08 Aug 2019 17:32:14 +0000

Collaborative goal-setting with trained health professionals reduced depression symptoms — but not hemoglobin A1c — compared with enhanced usual care among veterans with type 2 diabetes and depression.
Medscape Medical News

Novel Program Uses Unused Vacation to Pay Down Student Debt

Thu, 08 Aug 2019 17:49:01 +0000

As part of a new program, employees at Montefiore St Luke's Cornwall in New York can convert unused paid time off into payment against student loan debt.
Medscape Medical News

Heat Headache for 2020 Planners as Tokyo Swelters a Year Before Games

Thu, 08 Aug 2019 16:17:28 +0000

Soaring temperatures in Japan have killed at least 57 people since late July, authorities said on Tuesday, highlighting the health threat to athletes and fans that Olympics organizers must tackle before next year's Tokyo games.
Reuters Health Information

Britain Faces Food Shortages in No-Deal Brexit Scenario, Industry Body Says

Thu, 08 Aug 2019 16:26:56 +0000

Britain will experience shortages of some fresh foods for weeks or even months if a disorderly no-deal Brexit leaves perishable produce rotting in lorries at ports, Britain's food and drink lobby warned on Wednesday.
Reuters Health Information

FDA Panel Rebuffs Broad Indication for Descovy for HIV PrEP

Thu, 08 Aug 2019 16:08:33 +0000

FDA advisers criticized Gilead's decision to seek broad approval for a drug for the prevention of HIV infections without having first studied its use widely in women.
Medscape Medical News

Higher Mortality With Off-Pump CABG in Left Main Disease

Thu, 08 Aug 2019 16:28:08 +0000

Post hoc analysis from the EXCEL trial indicates off-pump surgery was associated with increased 3-year all-cause death and more incomplete revascularization than on-pump in left main disease.
Medscape Medical News

Thailand Unveils First Batch of Medical Marijuana for Hospital Distribution

Thu, 08 Aug 2019 15:05:59 +0000

Thailand delivered 4,500 bottles of cannabis oil to treat hospital patients on Wednesday, its first official use of marijuana for medical purposes since a measure legalizing such use took effect this year.
Reuters Health Information

Defying Congress, Trump Administration Looks to Shift Billions in Foreign Aid

Thu, 08 Aug 2019 15:12:02 +0000

President Donald Trump's administration has ordered a review of foreign aid that critics fear could lead to sharp cuts in funds for global health, peacekeeping, narcotics control and other programs despite their having been approved by Congress.
Reuters Health Information

Biologic Therapy Tied to Less Coronary Inflammation in Psoriasis

Thu, 08 Aug 2019 15:28:01 +0000

Patients with psoriasis treated with various biologic therapies had a less cardiac inflammation, measured using a novel marker.
Medscape Medical News

China Restricts Opioid in Tighter Painkiller Controls

Thu, 08 Aug 2019 14:20:18 +0000

China has imposed new restrictions on the opioid oxycodone, its drug regulator said, as the country tightens control of its painkillers industry in the battle against drug addiction.
Reuters Health Information

West Nile Virus Neuroinvasive Disease On the Rise

Thu, 08 Aug 2019 13:55:22 +0000

Healthcare providers should consider arboviral infections in patients with aseptic meningitis or encephalitis and perform appropriate diagnostic tests, the CDC cautions.
Medscape Medical News

Federal Experts' Advice on HPV Vaccine Could Add Confusion

Thu, 08 Aug 2019 14:08:46 +0000

A federal advisory panel says people aged 27 to 45 may benefit from the human papillomavirus vaccine, but some worry that the advice doesn't provide clear guidance about who are candidates for the vaccine.
Kaiser Health News

«Если бы такое решение приняли за меня, мне бы пришлось уйти из профессии»

Thu, 08 Aug 2019 19:09:58 +0000

Президент России Владимир Путин поручил правительству до 1 декабря 2019 года подготовить предложения о возможности направления выпускников вузов, получивших медобразование за бюджетный счет, на работу по распределению. Медновости узнали отношение к такому радикальному способу решить кадровую проблему выпускников медвузов, молодых врачей и опытных профессионалов.

Замена красного мяса курицей связано со снижением риска рака молочной железы

Thu, 08 Aug 2019 19:15:09 +0000

Результаты нового крупного исследования показали, что замена красного мяса на мясо птицы может значительно снизить риск рака молочной железы. Американские ученые обнаружили, что употребление большого количества красного мяса связано с повышенным риском развития инвазивного рака молочной железы, но употребление большого количества мяса домашней птицы связано с уменьшением риска.

High Rate of Suicidal Thoughts in Preteens

Thu, 08 Aug 2019 10:53:23 +0000

Results of a three-phase, longitudinal follow-up study show up to 18% of preteens experience suicidal ideation and that risk factors for these thoughts differ by gender.
Medscape Medical News

Reserve Gadolinium for MS Diagnosis Only?

Thu, 08 Aug 2019 11:41:58 +0000

A new study supports limiting the use of brain MRI scans using gadolinium-based contrast agents for purposes of monitoring multiple sclerosis disease activity.
Medscape Medical News

Прием ибупрофена при остеоартрите чреват сердечно-сосудистыми заболеваниями

Thu, 08 Aug 2019 10:12:40 +0000

Болеутоляющие лекарственные препараты, такие как ибупрофен и напроксен, могут повысить риск возникновения заболеваний сердца и инсульта у людей с остеоартритом.

Drug Assistance Programs Offer Little Charity to Uninsured

Wed, 07 Aug 2019 17:52:30 +0000

Many patients who receive assistance from charities set up to defray prescription drugs costs may already have insurance that covers most the cost for their medications, a U.S. study suggests.
Reuters Health Information

FDA OKs Oral Ferric Maltol for Iron Deficiency in Adults

Wed, 07 Aug 2019 18:46:44 +0000

Accrufer might lessen the need for patients to progress to intravenous iron therapy, leading to a change in the current paradigm for the treatment of iron deficiency anemia, the company said.
FDA Approvals

Walgreens to Close About 200 Stores in United States

Wed, 07 Aug 2019 17:24:27 +0000

Walgreens Boots Alliance Inc said on Tuesday it plans to close about 200 U.S. stores and expects to record related pre-tax charges of between $1.9 billion and $2.4 billion.
Reuters Health Information

EU Approves Dupixent for Adolescent Eczema

Wed, 07 Aug 2019 17:15:20 +0000

Dupixent (dupilumab) has won regulatory approval in Europe for moderate-to-severe cases of eczema in adolescents, Sanofi and Regeneron said.
International Approvals

AI Detects 'Hidden' AFib During Normal Sinus Rhythm

Wed, 07 Aug 2019 16:46:14 +0000

ECGs are often insufficient to detect atrial fibrillation, leaving patients open to potential stroke. A new artificial intelligence model rapidly identifies AF, even during sinus rhythm.
Medscape Medical News

Ebola Lingers in Survivors and Care Team Precautions Needed

Wed, 07 Aug 2019 15:06:38 +0000

New findings of significant vitreoretinal pathology in Ebola survivors have safety implications for surgical teams that will treat these patients.
Medscape Medical News

FDA Gives Go-ahead for More Trials of Paclitaxel Devices in PAD

Wed, 07 Aug 2019 15:37:01 +0000

The agency says clinical trials will require 'informed consent and close safety monitoring,' but stands firm on its warning about select use of these stents in clinical practice.
News Alerts

CBT Best First-Line Treatment for Major Depression in Youth?

Wed, 07 Aug 2019 12:52:25 +0000

Adding an antidepressant to cognitive behavioral therapy provides no additional benefit over CBT alone in reducing symptoms in youth with major depression, new research shows.
Medscape Medical News

Clozapine May Best Other Second-Generation Antipsychotics for Schizophrenia, but Concerns Remain

Wed, 07 Aug 2019 12:37:43 +0000

Clozapine appears to be more effective for severe schizophrenia than other second- generation antipsychotics (SGAs), but safety concerns remain, a systematic review and meta-analysis suggests.
Reuters Health Information

Common Consumer Products Play a Major Role in Pediatric TBI

Wed, 07 Aug 2019 11:53:39 +0000

Nearly 3 of 4 nonfatal traumatic brain injuries in children and youth that require a visit to the emergency department involve common consumer products, new research shows.
Medscape Medical News

Racism in Med School May Keep Doctors From Areas of Need

Wed, 07 Aug 2019 11:09:28 +0000

Factors such as students having a perception that their school was committed to diversity may encourage more to practice in high-need areas, a study finds.
Medscape Medical News

Half of NCI Cancer Center Directors Collect Industry Payments

Wed, 07 Aug 2019 11:34:19 +0000

Some of the payments were for more than $5000, and one director pocketed $2.27 million in 2017. Is this in the public interest?
Medscape Medical News

Ученые обнаружили какие изменения в мозге вызывает загрязненный воздух

Wed, 07 Aug 2019 17:29:15 +0000

Американские ученые связывают загрязнение воздуха в результате дорожного движения с ростом тревожных расстройств у детей, поскольку вдыхаемые мелкодисперсные частицы воздействуют на мозг.

Epilepsy Patients May Live Longer With Specialist Care

Wed, 07 Aug 2019 10:05:05 +0000

People with epilepsy who receive care from specialists may be less likely to die prematurely than their counterparts who don't, a Canadian study suggests.
Reuters Health Information

Tecentriq Improves Progression-Free Survival in Advanced Bladder Cancer

Wed, 07 Aug 2019 10:08:50 +0000

Roche Holding said Tecentriq (atezolizumab) combined with platinum-based chemotherapy reduced the risk of disease progression in patients with previously untreated locally advanced or metastatic urothelial carcinoma, the Swiss pharma company said on Monday.
Reuters Health Information

FDA Nixes, for Now, Lutonix Paclitaxel-Coated Balloon in PAD

Wed, 07 Aug 2019 09:06:52 +0000

The device maker says the PMA application for the paclitaxel-coated balloon remains very active and that it will provide additional data to support approval.
Medscape Medical News

AAO-HNSF Updates Guideline for Sudden Hearing Loss

Wed, 07 Aug 2019 07:14:58 +0000

The recommendations against routine CT testing, lab tests, and various prescription drugs are particularly important for emergency and primary care physicians who may not know these are not indicated.
Medscape Medical News

More Naloxone Being Dispensed, but Not Nearly Enough, CDC Says

Wed, 07 Aug 2019 05:55:05 +0000

Nearly 9 million more naloxone prescriptions would have been dispensed in 2018 had every patient who received a high-dose opioid prescription been offered naloxone, as recommended by the CDC.
Medscape Medical News

Rural Hospitals Get a Boost From CMS

Wed, 07 Aug 2019 06:26:29 +0000

The wage index will be increased for hospitals in low-wage areas, giving rural hospitals more money to hire and retain highly skilled staff members.
Medscape Medical News

Диспансеризация 2019

Wed, 07 Aug 2019 11:55:38 +0000

Всероссийский союз страховщиков провел конференцию для журналистов «ОМС: права и новые возможности российских пациентов». Что система ОМС предлагает сегодня пациентам? Кто такие страховые представители и как они работают? Как проходит диспансеризация населения? В каких случаях чаще всего нарушаются права пациентов? Как страховые медорганизации защищают права пациентов?

Вентиляторы в жару: зло или благо?

Wed, 07 Aug 2019 11:29:20 +0000

Австралийские исследователи ставят под сомнение текущее руководство ВОЗ, согласно которому не следует использовать электрические вентиляторы при температуре выше 35°C, а также рекомендации, основанные на показателях теплового индекса.

In Extreme Heat, Electric Fans Inadvisable Unless It's Humid

Tue, 06 Aug 2019 23:21:54 +0000

In extreme heat, electric fans may offer some relief when it's very humid, but when temps are dangerously high and humidity is low, fans can actually make a person feel hotter, increasing strain on the heart and raising core temperature, a new report warns.
Reuters Health Information

Doctors Need to Move Beyond Medical Societies, Eric Topol Says

Tue, 06 Aug 2019 20:27:52 +0000

A new commentary in The New Yorker urges physicians to organize to better serve both their patients and their own health.
Medscape Medical News

Nobio Gets FDA Approval for Anti-Bacterial Dental Fillings

Tue, 06 Aug 2019 17:53:32 +0000

Israel's Nobio Ltd said on Monday it received approval from the U.S. Food and Drug Administration to market its anti-bacterial composite designed to remain in the teeth for decades.
Reuters Health Information

Ultrasound-Guided Thoracentesis Appears Safe With Novel Oral Anticoagulants or Clopidogrel

Tue, 06 Aug 2019 17:56:05 +0000

Rates of significant bleeding complications are very low after ultrasound-guided thoracentesis in patients on novel oral anticoagulants (NOACs) and/or clopidogrel, a retrospective analysis found.
Reuters Health Information

Pneumococcal Vaccine Safe, Effective in Adults With Stable HIV

Tue, 06 Aug 2019 18:05:24 +0000

Pneumococcal vaccination is safe and effective in people with HIV who are stable on antiretroviral therapy (ART), researchers say.
Reuters Health Information

Pancreas-Tail Radiation Linked to Increased Diabetes Risk

Tue, 06 Aug 2019 18:14:25 +0000

Radiation to the tail of the pancreas as part of childhood cancer treatment is associated with an increased risk of subsequent diabetes, according to findings from the Childhood Cancer Survivor Study (CCSS).
Reuters Health Information

Superbugs Found Lurking in London Underground and Hospitals

Tue, 06 Aug 2019 18:00:02 +0000

Scientists have found multidrug-resistant "superbug" bacteria lurking on cash machines, escalators and handrails in London's underground rail system, shopping centers and hospitals and say they pose a potential risk to public health.
Reuters Health Information

Drug Industry Urges Canada to Act Early on U.S. Import Plan

Tue, 06 Aug 2019 17:42:13 +0000

Canada's main pharmaceutical lobby group has urged the government not to wait for drug shortages before responding to U.S. plans to import Canadian drugs, according to documents seen by Reuters.
Reuters Health Information

Transgender Youth May Produce Viable Sperm After Stopping Feminizing Medications

Tue, 06 Aug 2019 17:45:46 +0000

Fertility preservation is possible, though not certain, for young feminizing individuals who have already started gender-affirming therapy, a small case study reveals.
Reuters Health Information

Obese People Get More Satisfaction From Food

Tue, 06 Aug 2019 16:58:25 +0000

In a chocolate-sampling study, obese individuals experienced higher taste perceptions, with delays in diminished satisfaction, compared with nonobese participants.
Medscape Medical News

High and Low Hemoglobin Tied to Long-Term Dementia Risk

Tue, 06 Aug 2019 17:40:39 +0000

Abnormal hemoglobin levels — both low and high — are associated with an increased risk of developing subsequent dementia, new research shows.
Medscape Medical News

Old MS Drug May Improve Cognitive Function

Tue, 06 Aug 2019 15:54:07 +0000

Dalfampridine, approved almost a decade ago for improving walking for patients with multiple sclerosis, may also improve information-processing speed, a measure of cognitive function, new research suggests.
Medscape Medical News

Better GI Tolerability With Diroximel vs Dimethyl Fumarate in MS

Tue, 06 Aug 2019 15:43:53 +0000

Topline results of EVOLVE-MS-2 show better gastrointestinal tolerability with diroximel fumarate compared with dimethyl fumarate in relapsing MS. FDA action is expected later this year.
Medscape Medical News

'Spin' Highly Prevalent in Top Psychiatry Journal Abstracts

Tue, 06 Aug 2019 14:22:06 +0000

More than half of clinical trial abstracts published in top psychiatry journals exaggerate the significance of study findings, a discovery that may lead to poor clinical decision making.
Medscape Medical News

ARB Recalls Fuel 'Biologically Implausible' Rise in Cancer Reports

Tue, 06 Aug 2019 14:52:37 +0000

A steep and transient rise in reporting of ARB-associated cancers after drug recalls highlights inherent shortcomings in the way adverse events are reported, researchers say.
Medscape Medical News

Deep Learning AI May Help Smokers Kick the Habit

Tue, 06 Aug 2019 12:54:55 +0000

A deep learning computer model matched smoking cessation experts in identifying daily locations where smokers were tempted to light up.
Medscape Medical News

Experts Decry Trump Characterization of 'Mentally Ill Monsters'

Tue, 06 Aug 2019 13:07:42 +0000

Although experts agree with President Trump's condemnation of this weekend's two mass shootings, they dispute his linking of mental illness and violence and his use of the term, 'mentally ill monsters.'
Medscape Medical News

FDA Class 1 Recall for Abbott's Ellipse Implantable Defibrillators

Tue, 06 Aug 2019 12:33:47 +0000

The global recall was issued because of a vulnerability in the electronic circuitry that may make the device unable to deliver high-voltage therapy.
News Alerts

Long-term Data Suggest 'Functional Cure' in Advanced Cancer

Tue, 06 Aug 2019 10:50:25 +0000

Long-term survival data from one of the first trials conducted with nivolumab show that some patients are living for years, suggesting a 'functional cure at least' say the authors.
Medscape Medical News

Yellow Lens Glasses Don't Improve Drivers' Night Vision

Tue, 06 Aug 2019 08:57:00 +0000

Touted to improve nighttime eyesight, yellow lens glasses don't help drivers see better and may, in fact, worsen vision, a new study suggests.
Reuters Health Information

BASEL IX: PE Uncommon in Patients Presenting With Syncope

Tue, 06 Aug 2019 09:39:18 +0000

Results from the randomized trial reinforce use of a tailored workup for pulmonary embolism, rather than systematic screening in patients presenting to the emergency department with syncope.
Medscape Medical News

Treatment-Independent Live Birth Common After Unsuccessful in Vitro Fertilization

Tue, 06 Aug 2019 08:16:46 +0000

Many women whose in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments are unsuccessful go on to achieve live births without further treatment, according to a retrospective study.
Reuters Health Information

Doctors Extract Tumor With 526 Teeth in Jaw of Indian Boy

Tue, 06 Aug 2019 08:16:35 +0000

Indian doctors removed a tumor with 526 teeth inside a seven-year-old boy's mouth, the medical team in the southern city of Chennai said on Friday.
Reuters Health Information

Neural Network Provides Real-Time Prediction of Kidney-Injury Risk

Tue, 06 Aug 2019 08:25:04 +0000

A neural-network system can provide continuous prediction of acute kidney injury (AKI) risk using electronic health record (EHR) data, researchers report.
Reuters Health Information

Exercise Training Reduces Bone Loss Tied to Gastric Bypass in Women

Tue, 06 Aug 2019 08:25:00 +0000

Exercise training can attenuate the bone loss that commonly follows Roux-en-Y gastric bypass (RYGB) in women with severe obesity, according to results from a randomized controlled trial.
Reuters Health Information

Only 1 in 6 U.S. Universities Are Smoke-Free

Tue, 06 Aug 2019 08:35:22 +0000

Universities across the United States have been slow to adopt anti-tobacco policies on campuses, researchers say, despite public health efforts to curb tobacco use, especially among teens and young adults.
Reuters Health Information

Measles Surveillance Lags in U.S. Workplaces, Expert Says

Tue, 06 Aug 2019 08:37:28 +0000

Monitoring for measles in U.S. workplaces needs improvement, especially in the healthcare sector, an occupational safety expert argues.
Reuters Health Information

Laypeople Likely Poorly Prepared to Apply Tourniquets After 'Stop the Bleed' Training

Tue, 06 Aug 2019 08:41:35 +0000

Participants who completed tourniquet training as part of the American College of Surgeons/U.S. government "Stop the Bleed" campaign are unlikely to be prepared to help bleeding individuals, researchers say.
Reuters Health Information

Сладкая зависимость

Tue, 06 Aug 2019 14:05:01 +0000

За последние 50 лет в мире удвоились производство и потребление сахара. И за удовольствием, которое мы получаем, съедая сладости, неизбежно следуют проблемы со здоровьем. Что нужно знать об этой проблеме, и можно ли исправить ситуацию рассказал член международного общества междисциплинарной эстетической и антивозрастной медицины (WOSIAM) Андрей Тарасевич.

Ученые назвали лучшие упражнения против ожирения для людей с генетической предрасположенностью

Tue, 06 Aug 2019 12:12:13 +0000

Ученые показали, что физические упражнения могут помочь предупредить ожирение даже у людей с генетической предрасположенностью к нему. В исследовании, опубликованном в PLOS Genetics, они определили шесть конкретных видов физической активности, которые достоверно помогают в такой ситуации.

Смертность пациентов после лечения туберкулеза в три раза выше средней

Tue, 06 Aug 2019 08:59:29 +0000

Согласно результатам нового канадского исследования, смертность пациентов, проходивших лечение от туберкулеза, значительно выше средней. Смертность после лечения в этой группе была почти в три раза выше, чем в контрольной группе.

Surge of Gun Violence Forces Chicago Hospital to Divert Patients

Mon, 05 Aug 2019 18:08:19 +0000

For 2 hours on Sunday, trauma patients coming to Mt. Sinai by ambulance were sent to other centers when the hospital was overwhelmed. The gun violence came amid two mass shootings in Texas and Ohio.
Medscape Medical News

Machine Learning Algorithms Classify Neurosurgical Skill

Mon, 05 Aug 2019 17:00:41 +0000

Machine learning algorithms classified level of neurosurgical skill with high accuracy, a study found.
Medscape Medical News

Most Americans Have Confidence in Doctors -- With Caveats: Survey

Mon, 05 Aug 2019 17:21:40 +0000

Three quarters of Americans have positive views of physicians, but many still worry about misconduct and lack of transparency.
Medscape Medical News

Drugmakers Master Rolling Out Their Own Generics to Stifle Competition

Mon, 05 Aug 2019 15:58:19 +0000

Known as 'authorized generics,' in-house spinoffs of brand-name drugs quietly undermine the competition.
Kaiser Health News

Clinical, Echo Outcomes After TAVR Improve on RAS Inhibitors

Mon, 05 Aug 2019 14:04:18 +0000

Cardiac remodeling, risk for atrial fib, and CV survival improved in TAVR patients discharged on meds like ACE inhibitors or ARBs; observational findings now under exploration in a randomized trial.
Medscape Medical News

Gastric Acid Inhibitor Use May Up Allergy Risk

Mon, 05 Aug 2019 12:09:59 +0000

Patients who take gastric acid inhibitors may have a greater risk of developing allergies and that risk appears to be significantly higher among women, a study found.
Medscape Medical News

Регулярная половая жизнь говорит о хороших шансах выжить после инфаркта

Mon, 05 Aug 2019 18:03:02 +0000

Люди, пережившие инфаркт, но продолжающие вести активную половую жизнь, имеют больше шансов прожить дольше, чем те, кто не занимается сексом. Исследование, которое провели ученые из Тель-Авивского университета, опубликовано в American Journal of Medicine.

Take Diabetes to Heart: New Subspecialty

Mon, 05 Aug 2019 09:01:25 +0000

The proposed curriculum would include elements of endocrinology, cardiology, and primary care, with aim of addressing unmet need.
Medscape Medical News

Анемию связали с повышенным риском развития деменции

Mon, 05 Aug 2019 12:05:16 +0000

Как низкий уровень гемоглобина, так и высокий, связаны с повышенным риском возникновения и развития деменции, в том числе болезни Альцгеймера, выяснили исследователи из Медицинского центра Университета Эразма Роттердамского. Полученные результаты опубликованы в Neurology.

Bangladesh Struggles With Worst Outbreak of Dengue Fever

Sat, 03 Aug 2019 17:56:18 +0000

Bangladesh is grappling with its worst outbreak of dengue fever, with hospitals packed with patients as the disease spreads rapidly in the densely-populated country.
Reuters Health Information

Active Sex Life Tied to Long-Term Survival After a Heart Attack

Sat, 03 Aug 2019 17:44:41 +0000

Heart attack survivors who have an active sex life are less likely than celibate counterparts to die in the decades following a first heart attack, a study in Israel suggests.
Reuters Health Information

For Some Surgeries, Hospital Rankings Not Tied to Better Outcomes

Sat, 03 Aug 2019 16:53:06 +0000

When it comes to common gastrointestinal operations, such as weight loss surgery, a U.S. hospital's ranking may not equate with better outcomes, a new study suggests.
Reuters Health Information

Hairdressers Are Willing to Help Customers Detect Skin Cancers

Sat, 03 Aug 2019 16:49:37 +0000

Most hair stylists at salons and barber shops may be interested in getting trained to detect skin cancers on the scalp, face and neck, researchers say.
Reuters Health Information

Telemedicine May Boost Unnecessary Antibiotic Prescribing in Kids

Sat, 03 Aug 2019 11:28:00 +0000

Antibiotics are often prescribed to children with respiratory tract infections (RTIs) during video-only direct-to-consumer (DTC) telemedicine visits, and parents are more satisfied with the video visit when it results in a prescription, a new study has found.
Reuters Health Information

Compensatory Strategies Yield Mixed Outcomes in People With Autism

Sat, 03 Aug 2019 11:28:11 +0000

Compensatory strategies used by people with autism to disguise the condition have both positive and negative consequences, researchers say.
Reuters Health Information

Neoadjuvant Radiotherapy Beneficial in Resectable Liver Cancer With Portal Vein Tumor Thrombus

Sat, 03 Aug 2019 11:34:11 +0000

Neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy boosts outcomes over those with hepatectomy alone in patients with resectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT), researchers from China report.
Reuters Health Information

Peripapillary Retinal Nerve Thinning Faster in People With Diabetes

Sat, 03 Aug 2019 11:41:34 +0000

People with type 2 diabetes show accelerated thinning of the peripapillary retinal nerve fiber layer (pRNFL), even in the absence of diabetic retinopathy (DR), according to South Korean researchers.
Reuters Health Information

Rwanda Seals Congo Border After 3rd Ebola Case in Goma

Sat, 03 Aug 2019 10:42:32 +0000

Rwandan authorities closed the border with the Ebola-hit Congolese city of Goma on Thursday for all people other than Congolese citizens leaving Rwanda, as a third case of Ebola was confirmed in Goma.
Reuters Health Information

Death Toll in UK Hospital Listeria Outbreak Rises to Six

Sat, 03 Aug 2019 10:46:08 +0000

Another person has died in a listeria outbreak caused by eating contaminated food in hospital, bringing the total number of deaths to six, Public Health England said on Thursday. The individual who died at Western Sussex Hospitals NHS Foundation Trust in southern England was one of nine confirmed cases of the infection, the public health agency said in a statement.
Reuters Health Information

Docs Get Tiny Raises While Nonprofit Healthcare CEOs Get > $10M

Fri, 02 Aug 2019 20:40:52 +0000

Executives at nonprofit healthcare systems receive large pay packages with double-digit increases, despite generally small salary increases for many physicians and frontline medical staff.
Medscape Medical News

CMS Aims to Reduce Physician EHR Burden, Provide More Data

Fri, 02 Aug 2019 19:18:47 +0000

A proposed physician fee schedule rule would make documentation easier; a separate rule would ease MIPS requirements, and a pilot program would give doctors Medicare data.
Medscape Medical News

FDA Approves First Drug for Tenosynovial Giant Cell Tumor

Fri, 02 Aug 2019 16:18:29 +0000

Tenosynovial giant cell tumor is a nonmalignant, rare tumor type that can cause debilitating symptoms and lead to joint replacements and even amputation.
FDA Approvals

Risk for Frailty High Among Community-Dwelling Older Adults

Fri, 02 Aug 2019 14:29:33 +0000

Understanding factors that increase risk is important for developing interventions, the authors write; an expert says delaying the onset of frailty is 'a critical public health challenge.'
Medscape Medical News

Federal Suit Alleges 'Staggering' Urine Drug Testing Fraud

Fri, 02 Aug 2019 13:41:55 +0000

Prosecutors say Comprehensive Pain Specialists saw urine tests as 'liquid gold,' and cheated Medicare and other taxpayer-funded health insurers by conducting needless urine drug tests.
Kaiser Health News

Music May Work as Well as Meds to Reduce Anesthesia-Related Anxiety

Fri, 02 Aug 2019 12:51:12 +0000

Listening to soothing music for a few minutes before getting a nerve-block might work as well as an anxiety drug to relax patients, a small study suggests.
Reuters Health Information

New Alzheimer's Blood Test 94% Accurate

Fri, 02 Aug 2019 12:42:37 +0000

When combined with age and APOE ε4 status, the blood test is 94% accurate in detecting brain amyloidosis and may be a "game changer" for the field.
Medscape Medical News

Индийские стоматологи удалили более 500 зубов у одного мальчика

Fri, 02 Aug 2019 17:56:22 +0000

Индийские врачи удалили опухоль, содержащую 526 маленьких зубов, у семилетнего ребенка. Пациент попал к ним с жалобами на боль и опухание челюсти. Специалисты говорят, что это самая крупная одонтома, которую они встречали.

U.S. Federal Death Penalty Protocol Faces Fresh Legal Scrutiny

Fri, 02 Aug 2019 11:10:08 +0000

Plans by President Donald Trump's administration to resume executions of inmates sentenced to death for federal crimes is set to face a stiff court challenge, but a judge's decision on the legality of its new protocol for lethal injections may come too late for five men scheduled to die starting in December.
Reuters Health Information

Ontario Needs More Healthcare Funding, Says Report on Serial Killer Nurse

Fri, 02 Aug 2019 10:45:46 +0000

Ontario needs to boost funding and staffing to resolve problems that allowed a Canadian nurse to murder eight and harm six other seniors in various nursing homes, according to a public inquiry report on Wednesday which called for sweeping changes to the province's long-term care system.
Reuters Health Information

Достаточное количество витамина А снижает риск рака кожи

Fri, 02 Aug 2019 12:59:56 +0000

У людей, рацион которых богат витамином А, риск плоскоклеточного рака кожи снижается на 17%, утверждают исследователи из Университета Брауна на основании анализа данных двух крупнейших долгосрочных обсервационных исследований. Результаты опубликованы в JAMA Dermatology.

New ADA Update: Liraglutide for Youth and Technology Issues

Fri, 02 Aug 2019 05:59:48 +0000

Liraglutide for youth, dulaglutide cardiovascular outcomes data, and 'time-in-range' guidelines inform the latest Living Standards updates.
Medscape Medical News

ICE Facility Physician Job Posting Draws Doctors' Ire

Fri, 02 Aug 2019 05:24:21 +0000

A job listing for a lead physician at a US Immigrations and Customs Enforcement detention facility required applicants to pass what some are calling a 'loyalty test.'
Medscape Medical News

«Профессия фармацевта столь многогранна, что хочется попробовать себя во всем»

Fri, 02 Aug 2019 11:52:05 +0000

Подведены итоги главного интеллектуального соревнования российских студентов – олимпиады «Я – профессионал». Своими впечатлениями от состязания и о карьерных планах в профессии рассказала серебряная медалистка олимпиады, выпускница Тихоокеанского государственного медуниверситета Юлия Парфенова.

[Review] New Zealand health system: universalism struggles with persisting inequities

Thu, 01 Aug 2019 23:00:09 +0000

New Zealand was one of the first countries to establish a universal, tax-funded national health service. Unique features include innovative Māori services, the no-fault accident compensation scheme, and the Pharmaceutical Management Agency, which negotiates with pharmaceutical companies to get the best value for medicines purchased by public money. The so-called universal orientation of the health system, along with a strong commitment to social service provision, have contributed to New Zealand's favourable health statistics.

[Therapeutics] The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

Thu, 01 Aug 2019 23:00:09 +0000

Developments in high-throughput microbial genomic sequencing and other systems biology techniques have given novel insight into the potential contribution of the gut microbiota to health and disease. As a result, an increasing number of diseases have been characterised by distinctive changes in the composition and functionality of the gut microbiota; however, whether such changes are cause, consequence, or incidental to the disease in question remains largely uncertain. Restoration of the gut microbiota to a premorbid state is a key novel therapeutic approach of interest, and faecal microbiota transplantation—the transfer of prescreened stool from healthy donors into the gastrointestinal tract of patients—is gaining increasing importance in both the clinical and research settings.

[Clinical Picture] A quest for Q fever

Thu, 01 Aug 2019 23:00:09 +0000

A 9-year-old girl was admitted to our hospital with status epilepticus. Earlier in the day, she had complained of a headache and started vomiting. She then lost consciousness and began having a fit; the status epilepticus lasted 30 min and was stopped by phenobarbital. She had a congenital heart defect—truncus arteriosus with interventricular communication—which was surgically corrected a few days after birth. The girl was on long-term treatment with low-dose aspirin as the antiaggregant. She had no features of Marfan's or Ehlers–Danlos syndromes.

[Articles] Prevalence, risk factors, and management of asthma in China: a national cross-sectional study

Thu, 01 Aug 2019 23:00:09 +0000

Asthma is prevalent but largely undiagnosed and undertreated in China. It is crucial to increase the awareness of asthma and disseminate standardised treatment in clinical settings to reduce the disease burden.

[Articles] Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40-week extension

Thu, 01 Aug 2019 23:00:09 +0000

In patients with chronic kidney disease and metabolic acidosis, veverimer safely and effectively corrected metabolic acidosis and improved subjective and objective measures of physical function.

[Department of Error] Department of Error

Thu, 01 Aug 2019 23:00:09 +0000

Beaglehole RH, Beaglehole R. Promoting radical action for global oral health: integration or independence? Lancet 2019; 394: 196–98—In this Comment, the sixth sentence of the fifth paragraph should read: “Despite the appointment in 2019 of a former executive director of the FDI to the Board of Directors of the NCD Alliance, there is a danger that oral health will continue to be neglected within this wider collaboration.” This correction has been made to the online version as of July 24, 2019.

[Correspondence] Can #MeToo abolish sexual harassment and discrimination in medicine?

Thu, 01 Aug 2019 23:00:09 +0000

“Discrimination is a disease, we must attack it wherever it appears. This applies to the opportunity to vote, to hold and retain a job, and to secure adequate shelter and medical care no less than to gain an education compatible with the needs and ability of the individual.”Harry S Truman

[Correspondence] Early career investigators and precision public health

Thu, 01 Aug 2019 23:00:08 +0000

The priority schema for strategies that will be most consequential for improving the public's health is in hot debate.1–3 Vocal sceptics of precision public health caution against precision-based approaches, suggesting that focusing on these advances is not worth the effort and could overshadow the true mission of public health. Indeed, some leaders are putting substantial energy into advancing a negative narrative on this topic. The nihilistic tone of these critiques is concerning for the field, but particularly for early career investigators, like us, who are engaged in precision-based research.

[Correspondence] Leading UNAIDS: a once-in-a-generation challenge?

Thu, 01 Aug 2019 23:00:08 +0000

The UN Secretary-General will soon appoint a new UNAIDS Executive Director. Like Richard Horton,1 we disagree with those who say that UNAIDS is no longer needed. AIDS is still a global crisis. Remarkable progress does not mean the job of ending AIDS is finished. Instead, it illustrates the uphill battle ahead.

[Correspondence] Is intima-media thickness a predictor for cardiovascular risk? – Authors' reply

Thu, 01 Aug 2019 23:00:08 +0000

We thank Alvaro Gonzalez-Cantero and colleagues for raising interesting questions regarding intima-media thickness as a predictor of cardiovascular disease.

[Correspondence] Is intima-media thickness a predictor for cardiovascular risk?

Thu, 01 Aug 2019 23:00:08 +0000

Ulf Näslund and colleagues1 suggest that the pictorial representation of silent atherosclerosis might contribute to the prevention of cardiovascular disease. However, several caveats need to be considered. The authors assume that increased intima-media thickness is still an established biomarker of subclinical atherosclerosis, but it is now known to be a very weak predictor of cardiovascular disease that does not add significant predictive capacity to traditional risk scores.2 Intima-media thickness measurement is no longer recommended in the 2013 American College of Cardiology and American Heart Association guidelines for cardiovascular disease risk prediction or in the 2016 European Guidelines on cardiovascular disease prevention in clinical practice.

[Correspondence] Brexanolone injection for post-partum depression treatment – Authors' reply

Thu, 01 Aug 2019 23:00:08 +0000

We are grateful to Jennifer Tufts, George Tang, and Jay Parekh for their thoughtful comments on our Article1 and appreciate the opportunity to discuss our study data in more detail and provide clarification. First, we agree with Tufts that the aetiology of post-partum depression might differ on the basis of its time of onset. However, the proportions of patients with symptom onset in the third trimester in study 2 (22% in both placebo and brexanolone 90 μg/kg per h arms) and the integrated analysis (28% in the placebo group, 26% in those taking 60 μg/kg per h brexanolone, and 22% in those in the 90 μg/kg per h group) are comparable.

[Correspondence] Brexanolone injection for post-partum depression treatment

Thu, 01 Aug 2019 23:00:08 +0000

The Article by Samantha Meltzer-Brody and colleagues1 showed the results of two trials analysing brexanolone, a positive allosteric modulator at the γ-aminobutyric-acid A (GABAA) receptor. Although the investigators used data on treatment with antidepressants to stratify their second and third randomisation schedules, we believe that the concomitant use of other GABAergic drugs by patients in this study has been overlooked and needs further analysis.

[Correspondence] Brexanolone injection for post-partum depression treatment

Thu, 01 Aug 2019 23:00:08 +0000

The Article on brexanolone injections by Samantha Meltzer-Brody and colleagues1 showed a significant reduction in symptoms of post-partum depression in two phase 3 clinical trials. These results coincide with previous studies2,3 that found that low allopregnanolone concentrations during pregnancy can predict post-partum depression and that its concentrations are negatively correlated with post-partum depressive symptoms. There are, however, some possible confounding factors, which the authors did not discuss, that warrant attention.

[Obituary] Lewis E Braverman

Thu, 01 Aug 2019 23:00:08 +0000

Endocrinologist who helped define thyroid function. Born in 1929 in Boston, MA, USA, he died from Waldenström macroglobulinemia on June 10, 2019, in Boston aged 90 years.

[Perspectives] Punitive social policy: an upstream determinant of health

Thu, 01 Aug 2019 23:00:08 +0000

“I will be sending a man to prison for asking for food when he was hungry”, a UK judge professed before sentencing a homeless person to 4 months of jail for persistent begging. This is not an isolated incident. Across Europe, growing numbers of vulnerable people are targeted by public authorities for so-called anti-social behaviour, including a seemingly irrepressible yet inexplicable urge to sleep on pavements rather than beds, or to engage in open displays of material hardship.

[Perspectives] Clarity in chaos

Thu, 01 Aug 2019 23:00:08 +0000

It feels inadequate to describe Esmé Weijun Wang's The Collected Schizophrenias as a beautiful little book, even though this is my initial response and I cannot ignore it. How could one person's experience with severe and enduring mental illness, containing so much struggle and confusion, be “beautiful”, and worse, “little”? On reflection, I'm responding to the tremendous care that Wang takes with her work, and her life—her conciseness, her refusal to waste words, and her overall curation of how she, and her mental illness, is seen.

[World Report] Africa's poorly kept science gender gap secrets

Thu, 01 Aug 2019 23:00:08 +0000

Progress towards getting girls interested in science in African countries has been good, but women scientist argue that more should be done to support their role in society. Paul Adepoju reports.

[World Report] North Korea “on the verge of a food crisis”

Thu, 01 Aug 2019 23:00:08 +0000

The International Federation of Red Cross and Red Crescent Societies warn against drought-driven food crisis. Sharmila Devi reports.

[World Report] Honduras's worst dengue outbreak in 50 years

Thu, 01 Aug 2019 23:00:08 +0000

Honduras is contending with more than 28 000 cases and at least 54 deaths, while the country battles other mosquito-spread diseases. Lise Alves reports.

[Comment] Global partnerships and the Chief Medical Officer's 2019 annual report

Thu, 01 Aug 2019 23:00:08 +0000

The Chief Medical Officer for England's 2019 annual report focuses on UK engagement with global health.1 The UK is a world leader in health, with an impressive track record of global collaboration, but there is no room for complacency. Globally, governments across the world are not on track to deliver the Sustainable Development Goals, and the UK must sustain its level of engagement in global health while being vigilant to the changing threats to health, abroad and at home. We as a global health community must also consider the commercial determinants of health and ill-health and the opportunities and challenges they present.

[Comment] JUUL Labs' sponsorship and the scientific integrity of vaping research

Thu, 01 Aug 2019 23:00:08 +0000

As of 2018, 98 countries regulate e-cigarettes, including their sale, marketing, packaging, manufacturing, taxation, reporting, and clean air laws.1 Some countries have banned e-cigarettes completely, such as Argentina, Saudi Arabia, and Singapore,1 whereas other countries, such as the UK, consider e-cigarettes as part of a public health harm reduction strategy.2 The USA has regulated e-cigarettes as a tobacco product since 2016. Launched in 2015, JUUL Labs Inc (hereafter JUUL Labs) is the current market leader in the USA for e-cigarettes and accounts for almost 80% of retail sales of e-cigarettes in the USA.

[Comment] Prevalence and burden of asthma in China: time to act

Thu, 01 Aug 2019 23:00:08 +0000

Asthma is a common chronic airway disease worldwide in children and adults.1,2 The prevalence of asthma is increasing in industrialised countries, whereas a rural upbringing has been shown to protect from allergies and asthma.3 China has developed from a traditional agricultural society into an industrialised country with dense populations in megacities and the accompanying challenges of air pollution. These rapidly changing lifestyle and environmental factors could affect the incidence and prevalence of asthma.

[Comment] Drug removal of gastric acid: a novel treatment of metabolic acidosis

Thu, 01 Aug 2019 23:00:08 +0000

Metabolic acidosis is a complication of chronic kidney disease1,2 associated with muscle wasting and reduced muscle strength, bone disease, reduced growth in children, progression of chronic kidney disease, and increased mortality.3 Treatment of metabolic acidosis with base therapy in patients with chronic kidney disease is recommended by most clinical practice guidelines.4 The base is usually given as sodium bicarbonate, sodium citrate, or potassium citrate and by increasing sources of citrate (fruit and vegetables).

[Editorial] Building capacity in Africa's national science academies

Thu, 01 Aug 2019 23:00:07 +0000

On July 23, the InterAcademy Partnership released Harnessing Science, Engineering and Medicine to Address Africa's Challenges, a call for greater collaboration and investment in Africa's national science academies from policymakers and international organisations such as the UN. Countries in Africa face enormous challenges that require scientific and technical solutions: climate change, infectious diseases such as HIV and Ebola virus disease, as well as non-communicable conditions. Across the continent, headway in achieving global Sustainable Development Goals (SDGs) is in places stagnant.

[Editorial] Therapeutics in The Lancet

Thu, 01 Aug 2019 23:00:07 +0000

This week we launch a new section in The Lancet, which aims to provide up-to-date evidence-based reviews for clinicians on new and up-and-coming therapeutic options for diseases. The primary focus will be on new drugs in a specific disease, but broad-based reviews on a drug class or on new non-pharmacological options will also be included. The first Therapeutics paper on faecal microbiota transplantation is an excellent example of emerging therapeutic indications for restoration of the gut microbiota and reviews the treatment of recurrent Clostridioides difficile infection and potential other clinical uses.

[Editorial] Saving the Pacific islands from extinction

Thu, 01 Aug 2019 23:00:07 +0000

Small island developing states are a distinct group of 58 low-lying island nations and territories across three geographical areas—Caribbean, Pacific, and Indian Ocean and African regions. For many, thoughts of the Pacific island countries conjure images of tropical beaches and pristine blue waters. But like all small island developing states, those in the Pacific region face threats to viability and survival due to their small landmass, geographical remoteness, and vulnerability to climate change and natural disasters.

Anesthesia Groups Endorse Updated AAP Advice on Dental Sedation

Thu, 01 Aug 2019 17:57:35 +0000

The updated guidance calls for at least two people with specific training and credentials be present when a child has deep sedation or general anesthesia for a dental procedure.
Medscape Medical News

Presidential Candidates Spar Over Medicare for All in Debates

Thu, 01 Aug 2019 17:16:59 +0000

The issue of how to provide healthcare cover more Americans and bring down costs consumed a quarter of the debate time on each night.
Medscape Medical News

APA Battles Trump Policy of Extended Use of 'Junk' Insurance

Thu, 01 Aug 2019 17:32:54 +0000

The American Psychiatric Association is part of a coalition that is in a legal battle against short-term insurance plans. They say these skimpier plans can leave people unable to pay for care.
Medscape Medical News

Dedicated Cardiac Arrest Rapid Response Teams Get Best Results

Thu, 01 Aug 2019 16:02:02 +0000

Hospitals with the best cardiac arrest outcomes have rapid response teams that function autonomously, exclusively, and without fear of reprisal, according to a new qualitative study.
Medscape Medical News

Physicians Pursue Incidental Findings for Nonclinical Reasons

Thu, 01 Aug 2019 15:13:18 +0000

Low cost-consciousness, community norms, and fear of lawsuits drive low-value follow-up of screening and diagnostic test results, a survey found.
Medscape Medical News

Atherosclerosis Risk Rises With Less Education, Via Smoking

Thu, 01 Aug 2019 14:25:01 +0000

The less education a person has, the more subclinical atherosclerosis on imaging, an effect mediated by smoking far more than other common risk factors, an observational study shows.
Medscape Medical News

Most Surgical Adverse Events Result From Human Error

Thu, 01 Aug 2019 12:11:19 +0000

Cognitive errors make up the lion's share of mistakes resulting from human deficiencies; therefore, the authors advocate for increased cognitive training to complement systems-based interventions.
Medscape Medical News

Americans Fail to Heed Physical Activity Guidance, Sitting More

Thu, 01 Aug 2019 12:32:32 +0000

Long hours in front of computers and personal devices are likely driving the significant increase in sedentary behavior, say experts, who also suggest technology may help reverse the troubling trend.
Medscape Medical News

Большинство россиян считает лечение рака легкого слишком дорогим и поэтому малодоступным

Thu, 01 Aug 2019 18:02:48 +0000

ВЦИОМ представил результаты опроса об информированности россиян о проблеме рака легкого и его лечении. По мнению большинства респондентов, рак легкого входит в тройку самых распространенных онкологических заболеваний, при этом его лечение труднодоступно и малоэффективно. Исследование было приурочено к Всемирному дню борьбы с раком легкого, который отмечается 1 августа.

Препараты для снижения кислотности желудочного сока увеличивают риск аллергии

Thu, 01 Aug 2019 18:30:55 +0000

Рецептурные лекарства от изжоги связаны с повышенным риском развития аллергии, согласно исследованию Венского медицинского университета, опубликованному в Nature Communications.

Nutrient May Protect the Fetal Brain From Prenatal Marijuana Use

Thu, 01 Aug 2019 10:55:05 +0000

Marijuana use during pregnancy has a harmful impact on fetal brain development, but higher maternal levels of choline may help mitigate some of the harm.
Medscape Medical News

Could a 'Manogram' Replace a Prostate Biopsy?

Thu, 01 Aug 2019 11:14:03 +0000

Could fast MRI imaging help some men avoid the pain and complications of a prostate biopsy?
Medscape Medical News

New Treatment Approach in Neuroblastoma Proposed

Thu, 01 Aug 2019 10:03:09 +0000

A new oncogene has been identified as a clear driver in the development of neuroblastoma and, as such, could serve as a potential therapeutic target for tumor regression.
Medscape Medical News

No Evidence of 'July Effect' in Cardiac Surgical Outcomes

Thu, 01 Aug 2019 10:44:01 +0000

July, when new residents begin their training, has been associated with poorer patient outcomes, owing to medical errors. Reassuring new results on cardiac surgery outcomes show no such effect.
Medscape Medical News

Should ADPKD Patients Be Screened for Hidden Aneurysms?

Thu, 01 Aug 2019 09:30:25 +0000

Screening patients with polycystic kidney disease who are at risk for brain aneurysms pays off, but current screening recommendations shouldn't be altered, say authors.
Medscape Medical News

«Редкий случай в российской врачебной практике»

Thu, 01 Aug 2019 12:39:18 +0000

Пациентка Института урологии и репродуктивного здоровья человека Сеченовского университета, которой в начале беременности удалили обширную злокачественную опухоль почки, родила здорового ребенка. Полгода назад казалось, что другого способа спасти женщину, кроме как прервать беременность, не существует.

Binge Drinking Rising Among Older US Adults, Study Finds

Thu, 01 Aug 2019 04:21:21 +0000

Binge drinking among adults aged 65 years or older was more common among men, those who used tobacco or cannabis, and those with fewer chronic diseases, a study found.
Medscape Medical News

Two-Thirds of U.N. Security Council Ask U.N. Chief for Syria Hospital Attacks Inquiry

Wed, 31 Jul 2019 22:33:32 +0000

Two-thirds of the United Nations Security Council - including the United States, Britain and France - asked Secretary-General Antonio Guterres on Tuesday to investigate attacks on U.N.-supported medical facilities in northwest Syria, diplomats said.
Reuters Health Information

'Presenteeism' Takes Toll on Menstruating Women

Wed, 31 Jul 2019 22:43:56 +0000

Women who push themselves to work or study despite menstrual symptoms like painful cramps may be less productive on those days and might benefit from being able to work from home or take a day off and make it up later, a large survey suggests.
Reuters Health Information

HHS Outlines Goals for Possible Future Canadian Drug Imports

Wed, 31 Jul 2019 18:43:21 +0000

The Trump administration plans to someday put forward proposals about Canadian drug imports; called a "mindshift" in the administration by HHS Chief Alex Azar.
Medscape Medical News

HIV PrEP Use Rising Among US Men Who Have Sex With Men

Wed, 31 Jul 2019 17:44:25 +0000

A growing proportion of American men who have sex with men (MSM) know they can take a pill to avoid infection with HIV and more of them are using it, a U.S. study suggests.
Reuters Health Information

Continuously Updated System Improves Information Sharing for Youth in Foster Care

Wed, 31 Jul 2019 17:38:47 +0000

Youth in foster care have high rates of medical, behavioral, and developmental problems that require health care services, but poor information exchange often impedes care coordination. In response to this problem, the Cincinnati Children's Hospital Medical Center (CCHMC) has developed a continuously updated information sharing system that improves communication between health care and child w...
Reuters Health Information

Two Powerful Canadian Provinces Argued Against Federal Drug Price Crackdown

Wed, 31 Jul 2019 17:35:10 +0000

Canada's two most populous provinces, Ontario and Quebec, have privately expressed concerns with a federal government plan to slash the price of patented drugs, arguing that such regulatory changes could hurt investment in life sciences.
Reuters Health Information

Complication of Eye Surgery Can Kill in a Minute

Wed, 31 Jul 2019 17:35:13 +0000

This rare complication of vitrectomy is almost always fatal. Some specialists have not heard of it, but they are now learning that reconfirming the location of the infusion cannula can save a life.
Medscape Medical News

AF Ablation, Bariatric Surgery Synergy Seen in the Very Obese

Wed, 31 Jul 2019 16:20:07 +0000

Shouldn't the weight-reduction surgery be offered prior to catheter ablation in the morbidly obese with atrial fibrillation? The answer isn't simple.
Medscape Medical News

'Deep' TMS Beats Standard TMS, Meds for Severe Depression

Wed, 31 Jul 2019 14:50:23 +0000

A novel repetitive form of TMS that reaches deeper into the brain is promising for alleviating symptoms of treatment-resistant depression, a new head-to-head study suggests.
Medscape Medical News

Findings That Led to $183 Million Drug Development Deal Questioned

Wed, 31 Jul 2019 12:04:41 +0000

Scientists tried to replicate some findings of a 'landmark' immunology study and were unable to do so.
Medscape Medical News

'I'm a Survivor': Incoming ADA President Has Type 1 Diabetes

Wed, 31 Jul 2019 12:32:54 +0000

Diagnosed with type 1 diabetes as a child in the 1950s, Robert H. Eckel, didn't want to study his own disease but instead was interested in type 2 diabetes and the 'cardiometabolic' consequences.
Medscape Medical News

Пожары в Сибири. В чем вред смога для сердца и что делать?

Wed, 31 Jul 2019 16:31:34 +0000

В Сибири продолжаются лесные пожары. Горят не менее полутора миллионов гектаров леса, жители сибирских городов жалуются на смог. Кардиолог Ярослав Ашихмин рассказывает о негативном воздействии дыма пожаров на сердечно-сосудистую систему и о том, что следует делать в такой ситуации.

Screen for Five Markers to Ward Off Heart Disease, Diabetes

Wed, 31 Jul 2019 09:00:47 +0000

'Doctors haven't been doing enough to measure waist circumference, but it's essential to identifying patients at metabolic risk earlier and preventing more cases of heart disease and diabetes.'
Medscape Medical News

Mayo Gets Perfect Score for Gastroenterology, GI Surgery

Wed, 31 Jul 2019 09:14:59 +0000

Mayo Clinic earned top marks for quality and patient experience outcomes and was recognized by gastroenterology experts as one of the top hospitals for challenging cases.
Medscape Medical News

CIEDs of Doubt: Pacemaker, ICD Complication Rates Can Vary Widely

Wed, 31 Jul 2019 09:18:01 +0000

The risks are 'underappreciated,' says an observer. The findings highlight how far the field has to go in improving the safety of device implantations and care of the patients, researchers say.
Medscape Medical News

Does a Family Member Work in Your Practice?

Wed, 31 Jul 2019 08:41:04 +0000

Family practice can be the family business.
Medscape Reader Polls

Johns Hopkins Tops US News List for Rheumatology Hospitals

Wed, 31 Jul 2019 08:50:34 +0000

Almost half of rheumatology experts surveyed consider the Baltimore hospital to be among the best for challenging rheumatology cases.
Medscape Medical News

Люди с ожирением получают больше удовлетворения от еды

Wed, 31 Jul 2019 10:01:56 +0000

Склонность к перееданию может частично зависеть от удовлетворения, получаемого от пищи. Новое исследование Университета Айовы, опубликованное в Journal of the Academy of Nutrition and Dietetics, обнаружило существенные различия во вкусовых ощущениях между участниками с нормальным/избыточным весом и участниками с ожирением.

Психотерапия может эффективно помочь при бессоннице

Wed, 31 Jul 2019 08:30:42 +0000

Хватит считать овец перед сном и пить теплое молоко, есть более эффективный способ борьбы с хронической бессонницей – когнитивно-поведенческая психотерапия. Как утверждают авторы нового исследования, такое лечение достаточно эффективно, но пока не используется широко, так как о нем до сих пор знают не многие врачи, а пациенты зачастую не имеют к нему доступа.

Riskiest Time for Surgery Patients Is Not in the Operating Room

Wed, 31 Jul 2019 01:32:50 +0000

The deadliest time for many surgery patients isn't when they're on the operating table, it's while they're recovering in the hospital and after they go home, a new study suggests.
Reuters Health Information

Google Translate Accurate for Translating Non-English Trial Reports

Wed, 31 Jul 2019 01:20:09 +0000

Google Translate provides accurate translations of randomized controlled trials published in languages other than English, researchers report.
Reuters Health Information

Digoxin Swings Toward Benefit in HFrEF, But Lack of Clarity Remains

Tue, 30 Jul 2019 16:57:41 +0000

The venerable drug is back in the news, with a propensity-matched analysis reporting poorer outcomes with digoxin withdrawal at hospital discharge and a new DIG analysis taking aim at prescription bias in observational studies.
Medscape Medical News

Vascular Death Tops Suicide After Psychiatric Discharge

Tue, 30 Jul 2019 17:01:38 +0000

Individuals with severe mental illness are more likely to die from a natural cause than an unnatural cause 2 to 5 years after discharge from inpatient psychiatric care.
Medscape Medical News

They May Owe Nothing: $500M Dialysis Bill Canceled

Tue, 30 Jul 2019 17:16:05 +0000

After reporting by KHN, NPR and CBS, Fresenius has agreed to waive a Montana man's huge bill for out-of-network dialysis care.
Kaiser Health News

Chilis Not So Hot for the Brain After All?

Tue, 30 Jul 2019 16:19:00 +0000

Contrary to previous findings that chili may enhance cognitive function, new research suggests consuming more than 50 g/day of hot chili peppers is linked to an increased risk of cognitive decline.
Medscape Medical News

Call-In Consults the Answer to Severe Child Psychiatrist Shortage?

Tue, 30 Jul 2019 16:32:14 +0000

Children in areas with statewide child psychiatric telephone consultation programs are 37% more likely to receive mental health services, suggests the first national study of its kind.
Medscape Medical News

Sacubitril/Valsartan Misses in HF, Preserved EF: PARAGON-HF

Tue, 30 Jul 2019 14:51:29 +0000

In the trial pitting Entresto against valsartan, the Novartis drug's effect on a composite primary end point fell short of significance in cursory top-line results announced by the company.
Medscape Medical News

'Most Confusing' Desmoid Tumors: Pazopanib Now an Option?

Tue, 30 Jul 2019 14:58:45 +0000

Several treatment options have been described for desmoid tumors, but none is approved. Now the French Sarcoma Group is adding pazopanib to the list, but this is premature, says an expert.
Medscape Medical News

Findings Fortify Low Riboflavin, Migraine Link

Tue, 30 Jul 2019 15:26:50 +0000

Treating migraine with nutritional supplements to increase levels of riboflavin in patients with vitamin B2 deficiency appears to cut the frequency and severity of headaches.
Medscape Medical News

Top US Psychiatric Hospitals Ranked

Tue, 30 Jul 2019 11:18:34 +0000

Johns Hopkins Hospital, New York-Presbyterian University Hospital, and the Menninger Clinic round out the top five psychiatry hospitals, according US News and World Report.
Medscape Medical News

Top US Neurology, Neurosurgery Hospitals Ranked

Tue, 30 Jul 2019 11:38:19 +0000

UCSF Medical Center, NewYork-Presbyterian Hospital and Northwestern Memorial Hospital round out the top five hospitals for neurology/neurosurgery according to US News & World Report's latest rankings.
Medscape Medical News

Expensive Gilead, Novartis Cancer Therapies Losing Patients to Experimental Treatments

Tue, 30 Jul 2019 11:48:30 +0000

Unusually high numbers of U.S. lymphoma patients are choosing experimental treatments over expensive cell therapies sold by Gilead Sciences Inc and Novartis AG, new data shows, helping explain why sales of the two products have not met rosy expectations.
Reuters Health Information

Patients Turn to Crowdfunding to Help Pay for CAR-T Cell Therapy

Tue, 30 Jul 2019 10:22:25 +0000

Patients are turning to crowdfunding campaigns to help pay for CAR-T cell therapy, both for the product and for indirect costs such as travel and accommodation.
Medscape Medical News

[Correspondence] The guidelines on infection control in prisons need revising

Tue, 30 Jul 2019 14:00:08 +0000

Owing to a series of environmental and individual risk factors within prisons worldwide, major infectious diseases have become substantially more prevalent.1 The proportion of prisoners in the world with HIV has been estimated at 3·8%, hepatitis C virus (HCV) at 15·1%, hepatitis B virus (HBV) at 4·8%, and tuberculosis at 2·8%.2 Since most prisoners will eventually be released back into their communities, these individuals have the potential to further spread these contagious diseases, presenting a risk to society.

Ученые подсчитали, сколько часов использования смартфона в день увеличивают риск ожирения

Tue, 30 Jul 2019 16:27:21 +0000

Согласно данным недавнего исследования, представленного на конференции Американской коллегии кардиологов в Латинской Америке, у студентов университета, использовавших смартфоны пять или более часов в день, риск ожирения повышен на 43% и чаще присутствуют другие привычки образа жизни, увеличивающие вероятность возникновения и развития сердечно-сосудистых заболеваний.

Cleveland Clinic Remains Top Cardiology, Heart Surgery Hospital

Tue, 30 Jul 2019 08:34:25 +0000

Cleveland Clinic and Mayo Clinic still top the list, while Cedars-Sinai, Los Angeles; New York-Presbyterian Hospital; and Massachusetts General Hospital round out the top five cardiology/heart surgery hospitals.
Medscape Medical News

Mayo Clinic Once Again Leads in Endocrinology Ranking

Tue, 30 Jul 2019 06:58:17 +0000

The hospital, which was also named the nation's best hospital, scored a perfect 100 for diabetes and endocrinology.
Medscape Medical News

FDA OKs Streamlined Lyme Disease Tests to Aid Earlier Diagnosis

Tue, 30 Jul 2019 06:18:13 +0000

The modified approach for detecting exposure to Borrelia burgdorferi uses two enzyme immunoassays, with no need for Western blot.
FDA Approvals

Женщины и молодые пациенты часто получают недостаточное лечение ишемической болезни сердца

Tue, 30 Jul 2019 09:27:49 +0000

Новое масштабное австралийское исследование показало, что многим пациентам с ишемической болезнью сердца (ИБС) в выписывают недостаточно необходимых лекарств, не проводят мониторинг основных факторов риска, а также назначают лечение, не дающее желательных результатов. Отдельную группу риска составляют женщины.

Sleep Disturbance Common Among Refugees and Asylum Seekers Attending Psychological Services

Tue, 30 Jul 2019 01:04:49 +0000

About three of four refugees and asylum seekers attending psychological services report moderate or severe sleep disturbance, researchers from Australia report.
Reuters Health Information

Toxic Seaweed a Menace to Caribbean Tourists

Tue, 30 Jul 2019 01:06:46 +0000

Tourists to the Caribbean may not realize that a brown drifting seaweed that's been piling up on beaches in recent years is dangerous, researchers say.
Reuters Health Information

Kissing Bugs in Arizona Do Not Appear to Transmit Chagas Disease to Humans, but Anaphylaxis Is Common

Tue, 30 Jul 2019 01:10:05 +0000

Bites from kissing bugs in Arizona that harbor Trypanosoma cruzi commonly cause allergic reactions but not Chagas disease, researchers report.
Reuters Health Information

Mesenchymal-Stromal-Cell Therapy Effective Long-Term for Crohn's Disease Perianal Fistulas

Tue, 30 Jul 2019 00:58:31 +0000

Most patients with Crohn's disease whose perianal fistulas close after allogeneic bone marrow-derived mesenchymal stromal cell (bmMSC) therapy remain fistula-free four years later, researchers from the Netherlands report.
Reuters Health Information

More Evidence Ties Preeclampsia to Long-Term Diastolic Dysfunction

Tue, 30 Jul 2019 00:59:07 +0000

Women who develop preeclampsia may face a wide variety of heart problems long after they give birth, a research review concludes.
Reuters Health Information

Vehicle Infotainment Systems Dangerously Distracting, Especially for Seniors

Tue, 30 Jul 2019 00:44:05 +0000

Many of the interactive information and entertainment systems turning up in newer cars may be distracting enough to increase the risk for accidents, especially for older drivers, a new AAA Foundation study finds.
Reuters Health Information

In the US, Getting the Right Medicine After MI May Depend on Where You Live

Tue, 30 Jul 2019 00:44:11 +0000

Where survivors of myocardial infarction (MI) live in the U.S. may affect their chances of getting the best medication to prevent a second MI, a new study suggests.
Reuters Health Information

Medicare Proposes Changes to Clinician Pay for E/M Visits

Mon, 29 Jul 2019 20:58:28 +0000

CMS cited points of agreement with proposals from the AMA's CPT Editorial Panel in its proposed 2020 clinician payment rule.
Medscape Medical News

Racial/Ethnic Disparities Continue in NICU Care

Mon, 29 Jul 2019 18:18:07 +0000

Extensive racial and ethnic disparities in the structure, processes, and outcomes of NICU care exist; however, there are multiple actionable steps to address the problem, experts say.
Medscape Medical News

'Reassuring': New Type 2 Diabetes Drugs Not Linked to UTIs

Mon, 29 Jul 2019 17:06:14 +0000

Analyses from 2 large databases find no greater risk for urinary tract infections with one kind of new type 2 diabetes agent, SGLT2 inhibitors, compared with DPP4 inhibitors or GLP1 receptor agonists.
Medscape Medical News

AF, Carotid Disease Synergistic for Risks for Stroke, Dementia

Mon, 29 Jul 2019 15:50:41 +0000

Patients with vascular disease and prior stroke may be less likely referred for AF ablation, 'but our results suggest that these sicker patients may actually gain the most benefit from AF ablation.'
Medscape Medical News

Dual Therapy for HIV Two-Stepping In

Mon, 29 Jul 2019 15:07:50 +0000

Multi-drug regimens are being paired down to two therapies, which might now be as effective and safe, and could signal a shake-up in HIV treatment.
Medscape Medical News

EMA Panel Recommends Ibalizumab for Multidrug-Resistant HIV-1

Mon, 29 Jul 2019 14:18:06 +0000

A European Medicines Agency advisory panel recommended marketing authorization for ibalizumab (Trogarzo, Theratechnologies International) for the treatment of patients with multidrug-resistant HIV-1 infection.
International Approvals

Acupuncture Shows Promise in Chronic Stable Angina

Mon, 29 Jul 2019 12:14:40 +0000

Acupuncture on relevant acupoints, added to standard antianginal medication, reduced angina frequency and pain intensity in a sham-controlled study conducted in China.
Medscape Medical News

Выгодный бизнес: в столичной частной клинике делал аборты представлявшийся врачом экономист

Mon, 29 Jul 2019 17:56:41 +0000

О нанесении тяжкого вреда жизни и здоровью гражданам в расположенном в центре Москвы ООО «Евроклиник» сообщила пресс-служба Росздравнадзора. Медикаменты для искусственного прерывания беременности назначались всем пришедшим на прием, включая пациентов, чей срок беременности превышал 12 недель, и несовершеннолетних, без предварительной диагностики.

Eye Injections Cost More Than Payers Think

Mon, 29 Jul 2019 11:38:45 +0000

The expense of each intravitreal injection is higher than the reimbursement rate, and retina specialists worry that one of the most frequently used codes in the specialty is undervalued.
Medscape Medical News

ВОЗ: электронные сигареты и системы для подогревания табака не предупреждают рак

Mon, 29 Jul 2019 17:53:53 +0000

Электронные сигареты и системы для нагревания табака не помогают предупреждать рак, заявили во Всемирной организации здравоохранения (ВОЗ). В ведомстве призывают не верить заявлениям производителей о безопасности продуктов.

Poor Diet Quality Tied to Frailty in Older Adults

Mon, 29 Jul 2019 09:59:25 +0000

When older people eat a poor-quality diet, they may be increasing their odds of becoming frail, a recent study suggests.
Reuters Health Information

In Breast Cancer, Delay Between Surgery and Chemo Harms Survival

Mon, 29 Jul 2019 08:46:33 +0000

There is 'room for improvement' in having women undergo adjuvant chemotherapy, say authors of a large study that found delays with reconstruction after mastectomy.
Medscape Medical News

First Kidney Failure, Then a $540,842 Bill for Dialysis

Mon, 29 Jul 2019 07:35:12 +0000

He needed the lifesaving treatment -- he never expected a half-million-dollar bill for 14 weeks of care.
Kaiser Health News

Плохое питание после 70 лет в два раза повышает риск одряхления

Mon, 29 Jul 2019 10:17:34 +0000

Исследование, длившееся четыре года, установило зависимость между плохим питанием в пожилом возрасте и высокими шансами одряхлеть. Пожилым людям следует употреблять в пищу цельные фрукты, свежие овощи, цельнозерновые продукты, нежирное молоко и молочные продукты, а также белок из разных источников.

Some Fever-Free Newborns Evaluated for Serious Infection in the ED Can Be Discharged Early

Sat, 27 Jul 2019 12:45:21 +0000

Infants younger than four weeks old who have a history of fever but who remain fever-free during an observation period in the emergency department for serious bacterial infection (SBI) are good candidates for early discharge, new research suggests.
Reuters Health Information

A Boston Hospital With a Farm on Its Roof Seeks to Inspire Others

Fri, 26 Jul 2019 17:57:57 +0000

A rooftop farm at a medical center in Massachusetts could serve as a model for hospitals that seek to encourage healthy eating, a new report says.
Reuters Health Information

Noninvasive Intracranial Pressure Tests 'Unreliable'

Fri, 26 Jul 2019 12:18:23 +0000

Common, noninvasive tests used to detect elevated intracranial pressure in brain injury are often unreliable and may mean doctors are overlooking many patients with this life-threatening condition.
Medscape Medical News

Longer Pregnancy Tied to Higher Risk of Stillbirth, Newborn Death

Fri, 26 Jul 2019 17:38:30 +0000

Pregnant women who continue to carry their babies after they reach full term have a higher risk of stillbirth and newborn deaths than mothers who deliver by 37 weeks' gestation, a recent study suggests.
Reuters Health Information

No One-Size-Fits-All for Serological Tests for Human Visceral Leishmaniasis

Fri, 26 Jul 2019 16:05:32 +0000

The accuracy of serological tests for human visceral leishmaniasis varies by methodology, manufacturer, and patient group, researchers from Brazil report.
Reuters Health Information

FDA Panel Recommends Nintedanib for Rare Lung Disease

Fri, 26 Jul 2019 15:01:37 +0000

Small effect size for primary endpoint in systemic sclerosis-associated interstitial lung disease study, and lack of significant difference between groups for secondary outcomes, were sticking points.
Medscape Medical News

Australian Endocrinologist Banned From Performing Breast Exams

Fri, 26 Jul 2019 12:51:54 +0000

Banning of endocrinologist from performing breast exams after a string of complaints highlights the need to explain why they are being performed and not just ask permission, finds Medical Board of Australia.
Medscape Medical News

Senate Committee Approves Plan to Alter Medicare Drug Pay

Fri, 26 Jul 2019 13:07:34 +0000

Over the objections of oncology associations and pharmaceutical lobbying groups, a committee has advanced a package intended to reduce drug costs but may place physician practices 'underwater.'
Medscape Medical News

FDA Adds Warning on Risk for PE, Death With Higher-Dose Xeljanz

Fri, 26 Jul 2019 13:28:13 +0000

The FDA has approved new warnings on risk for blood clots and death with the 10-mg twice-daily dose of tofacitinib, based on data from an ongoing postmarketing safety study.
News Alerts

Burnout and Racial Bias Among Residents: Chicken or Egg?

Fri, 26 Jul 2019 13:38:13 +0000

Resident physicians experiencing burnout are more likely to demonstrate implicit and explicit bias toward black patients than their peers, a longitudinal study suggests.
Medscape Medical News

CSF Testing Common in Some Children but Positive Results Rare

Fri, 26 Jul 2019 12:37:08 +0000

Nonculture infection tests of cerebrospinal fluid (CSF) in otherwise healthy children very rarely yields results requiring clinical intervention, according to new research.
Reuters Health Information

Intervention for Caregivers of Dementia Patients Has Lasting Effects

Fri, 26 Jul 2019 12:24:42 +0000

An intervention to reduce depression and anxiety in people caring for a relative with dementia continues to be clinically effective six years after delivery, new research shows.
Reuters Health Information

Lymphedema After Axillary Node Dissection Linked With Obesity, Longer Neoadjuvant Chemo

Fri, 26 Jul 2019 12:16:44 +0000

Increasing body mass index and longer neoadjuvant chemotherapy (NAC) are associated with a higher risk of lymphedema in women who undergo axillary lymph node dissection, researchers say.
Reuters Health Information

Weight Gain on INSTI-based HIV Antiretrovirals

Fri, 26 Jul 2019 12:16:00 +0000

Dolutegravir and tenofovir alafenamide can lead to weight gain, especially in women, according to new data that are changing the way researchers look at their study populations.
Medscape Medical News

Non-Invasive Intracranial Pressure Tests 'Unreliable'

Fri, 26 Jul 2019 12:18:23 +0000

Common, non-invasive tests used to detect elevated intracranial pressure in brain injury are often unreliable and may mean doctors are overlooking many patients with this life-threatening condition.
Medscape Medical News

Flag on the Field for Atrial Fibrillation in Retired NFL Players

Fri, 26 Jul 2019 12:20:39 +0000

New research suggests a link between strength training in these former elite athletes and a markedly higher risk for atrial fibrillation but one expert cautions that the findings are not definitive.
Medscape Medical News

CHMP Backs Inhaled Levodopa (Inbrija) for Parkinson's 'Off' Episodes

Fri, 26 Jul 2019 11:22:34 +0000

Levodopa inhalation powder is safe and effective in improving motor function during 'off' periods in patients with Parkinson's disease.
International Approvals

Pediatric Lymphoma Joins Family of BRCA2 Cancers

Fri, 26 Jul 2019 10:01:04 +0000

Researchers call for genetic testing of all survivors of pediatric non-Hodgkin lymphoma after data revealed BRCA2 is implicated in the childhood disease.
Medscape Medical News

EMA Panel Backs Cannabis Drug for Severe Epilepsy

Fri, 26 Jul 2019 10:20:17 +0000

CHMP gives thumbs up to GW Pharma's cannabidiol oral solution (Epidyolex) as an adjunctive treatment of Lennox-Gastaut syndrome and Dravet syndrome.
International Approvals

Cause of Common, Incurable Movement Disorder Pinpointed?

Fri, 26 Jul 2019 10:44:11 +0000

A new brain mapping technique is providing fresh insight into a common, incurable — but relatively unknown — movement disorder that shares some similarities with Parkinson's disease.
Medscape Medical News

CV Risk Rises When Payers Deny PCSK9 Inhibitor Coverage

Fri, 26 Jul 2019 09:04:39 +0000

'We see strong suggestions of what we feared would be true,' said one. Patients with prescriptions for the drugs had more MIs and other CV events if payers didn't cover them or they went unfilled.
Medscape Medical News

Запрет курения в общественных местах существенно снижает распространенность инфаркта

Fri, 26 Jul 2019 15:11:15 +0000

Частота возникновения инфарктов миокарда среди пожилых людей в Шотландии снизилась за десятилетие после вступления в силу общенационального запрета на курение в помещении, согласно новому исследованию Института здоровья и благополучия при Университете Глазго, опубликованному в Circulation: Cardiovascular Quality and Outcomes.

Новые данные: тестостерон увеличивает либидо женщин после менопаузы

Fri, 26 Jul 2019 15:15:44 +0000

Врачи давно рассматривали возможность использования тестостерон в малых дозах для улучшения сексуальной функции женщин, но доказательств безопасности и эффективности его применения до сих пор было недостаточно. Новая статья говорит, что тестостерон оказался эффективным при снижении сексуального влечения у женщин в период постменопаузы.

Вирусные гепатиты: заблуждения и факты

Fri, 26 Jul 2019 08:01:38 +0000

28 июля отмечается Всемирный день борьбы с гепатитом, который проводится под эгидой ВОЗ, принявшей глобальную стратегию по борьбе с этой инфекцией. Цель стратегии: полностью уничтожить вирусный гепатит к 2030 году. А это невозможно без повышения осведомленности о способах профилактики, диагностики и лечения заболевания.

Spinal Stimulation May Best 'Medicine' for Intractable Spine, Limb Pain

Thu, 25 Jul 2019 22:38:21 +0000

In patients with intractable spine and limb pain, spinal stimulation (SS), particularly with newer technologies, was associated with better pain relief than medical therapy, a systematic review and meta-analysis reveals.
Reuters Health Information

Bias, Other Factors Limit Minority Representation in Academic Pediatrics

Thu, 25 Jul 2019 22:31:07 +0000

Bias, racism and a lack of role models are barriers to greater representation of underrepresented minorities (URM) in academic pediatric medicine, researchers report.
Reuters Health Information

Home Health Care Aides Often Face Verbal Abuse From Clients

Thu, 25 Jul 2019 22:31:20 +0000

For many home healthcare aides, verbal abuse from clients or clients' family is a real problem, a U.S. study suggests.
Reuters Health Information

[Viewpoint] Sexual and reproductive health and rights and population policies: from “either/or” to “both/and”

Thu, 25 Jul 2019 23:00:10 +0000

In 2018, The Lancet published Accelerate progress—sexual and reproductive health and rights for all: report of the Guttmacher–Lancet Commission,1 the most comprehensive and definitive review of this field since the Programme of Action of the International Conference on Population and Development (ICPD) in 1994.2 The ICPD resolved many longstanding and sometimes bitter disagreements and debates, but, as the Lancet Commission shows, some remain. We identify population growth and sustainable development, people and the planet, and reproductive and sexual rights as the three most important issues facing the field today and propose responses.

[Health Policy] Brazil's unified health system: the first 30 years and prospects for the future

Thu, 25 Jul 2019 23:00:09 +0000

In 1988, the Brazilian Constitution defined health as a universal right and a state responsibility. Progress towards universal health coverage in Brazil has been achieved through a unified health system (Sistema Único de Saúde [SUS]), created in 1990. With successes and setbacks in the implementation of health programmes and the organisation of its health system, Brazil has achieved nearly universal access to health-care services for the population. The trajectory of the development and expansion of the SUS offers valuable lessons on how to scale universal health coverage in a highly unequal country with relatively low resources allocated to health-care services by the government compared with that in middle-income and high-income countries.

[Clinical Picture] A recurrent lump in the groin poses a diagnostic problem

Thu, 25 Jul 2019 23:00:09 +0000

A 51-year-old man attended our outpatient clinic complaining of repeated bouts of pain in his left groin. He said he had a lump that appeared intermittently in the area, and because of this, he regularly wore firm underwear. In his medical history, it was noted that 9 years earlier he had undergone an open flat mesh repair of a left inguinal hernia. 14 months later, however, the problem had recurred; at this stage, he was managed by a different surgeon—who had not been involved in the original operation—who did a further open mesh repair.

[Articles] Mapping the global endemicity and clinical burden of Plasmodium vivax, 2000–17: a spatial and temporal modelling study

Thu, 25 Jul 2019 23:00:09 +0000

Our study highlights important spatial and temporal patterns in the clinical burden and prevalence of P vivax. Amid substantial progress worldwide, plateauing gains and areas of increased burden signal the potential for challenges that are greater than expected on the road to malaria elimination. These results support global monitoring systems and can inform the optimisation of diagnosis and treatment where P vivax has most impact.

[Articles] Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study

Thu, 25 Jul 2019 23:00:09 +0000

High-resolution maps of P falciparum provide a contemporary resource for informing global policy and malaria control planning, programme implementation, and monitoring initiatives. Amid progress in reducing global malaria burden, areas where incidence trends have plateaued or increased in the past 5 years underscore the fragility of hard-won gains against malaria. Efforts towards elimination should be strengthened in such areas, and those where burden remained high throughout the study period.

[Articles] Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: a pragmatic, randomised controlled trial

Thu, 25 Jul 2019 23:00:09 +0000

Septoplasty is more effective than non-surgical management for nasal obstruction in adults with a deviated septum. This effect was sustained up to 24 months of follow-up.

[Articles] HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial

Thu, 25 Jul 2019 23:00:09 +0000

We did not find a substantial difference in HIV risk among the methods evaluated, and all methods were safe and highly effective. HIV incidence was high in this population of women seeking pregnancy prevention, emphasising the need for integration of HIV prevention within contraceptive services for African women. These results support continued and increased access to these three contraceptive methods.

[Department of Error] Department of Error

Thu, 25 Jul 2019 23:00:09 +0000

Nosten FH, Pyae Phyo A. New malaria maps. Lancet 2019; 394: 278–79—In this Comment, the spelling of author Aung Pyae Phyo's name was incorrect. This correction has been made to the online version as of July 1, 2019, and the printed version is correct.

[Department of Error] Department of Error

Thu, 25 Jul 2019 23:00:09 +0000

Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial Consortium. HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial. Lancet 2019; http://dx.doi.org/10.1016/S0140-6736(19)31288-7. On page 8 of this Article (published Online First on June 13), the last sentence of the first paragraph should be “Although this trial had low statistical power to detect an increase in HIV incidence of less than 30%, for individual women at very high HIV risk, we acknowledge that even a relatively small effect might be important in contraceptive and HIV prevention decision making.” This correction has been made to the online version as of June 13, and will be made to the printed Article.

[Department of Error] Department of Error

Thu, 25 Jul 2019 23:00:09 +0000

Yousuf H, Narula J, Zwetsloot P-P, et al. Using entertainment to improve lifestyles and health. Lancet 2019; 394: 119–20—In this Correspondence, the country in which the movie based on the 11th season of SpangaG will be distributed in has been changed from Germany to the Netherlands. This correction has been made to the online version as of July 15, 2019.

[Correspondence] The guidelines on infection control in prisons need revising

Thu, 25 Jul 2019 23:00:09 +0000

Owing to a series of environmental and individual risk factors within prisons worldwide, major infectious diseases have become substantially more prevalent.1 The proportion of prisoners in the world with HIV has been estimated at, hepatitis C virus (HCV) at 15·1%, hepatitis B virus (HBV) at 4·8%, and tuberculosis at 2·8%.2 Since most prisoners will eventually be released back into their communities, these individuals have the potential to further spread these contagious diseases, presenting a risk to society.

[Correspondence] Tuberculosis elimination in Canada

Thu, 25 Jul 2019 23:00:09 +0000

We read with interest Paul Webster's World Report1 about the tuberculosis epidemic among Inuit people in Canada. Webster might have been overoptimistic in asserting that “Canada is on track to meet the eradication goals for tuberculosis set by the high-level meeting”.1 Eradication is defined as less than 0·1 tuberculosis cases per 100 000 population by 2050 for countries with a low incidence of tuberculosis.2 The incidence of tuberculosis in Canada has been stagnant for more than a decade (figure), and the incidence among First Nations people, Inuit people, and those born outside of Canada is still disproportionately high.

[Correspondence] Multidrug-resistant tuberculosis – Authors' reply

Thu, 25 Jul 2019 23:00:09 +0000

We thank José A Caminero and colleagues for their Correspondence. We agree that our findings1 leave uncertainty about optimal duration and number of drugs needed to treat patients with multidrug-resistant tuberculosis (MDR-TB). In our study,1 the optimal number of effective drugs (based on the maximal odds of success with lowest odds of mortality) was five in the initial phase and four in the continuation phase and the total optimal duration of treatment was 19–22 months. However, this analysis included all patients treated, many of whom did not receive the three drugs found most effective in our analyses: later-generation fluoroquinolones, linezolid, and bedaquiline, which are considered core drugs in the new recommendations by WHO.

[Correspondence] Multidrug-resistant tuberculosis

Thu, 25 Jul 2019 23:00:09 +0000

Management of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis has never been easy, mirrored by the low proportion of successfully treated patients with MRD-TB of just 55% globally. In 2018, WHO released a Rapid Communication1 recommending the use of levofloxacin (or moxifloxacin), bedaquiline, linezolid, clofazimine and cycloserine (or terizidone) in longer MDR-TB regimens, largely on the basis of findings of the Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017.

[Correspondence] Multidrug-resistant tuberculosis

Thu, 25 Jul 2019 23:00:09 +0000

We commend the Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–20171 on their important findings but have questions about the analyses. We understand that individuals not given the drug under study were matched multiple times by propensity scoring to individuals to whom the drug was given. Did the investigators control for this multiple matching in their analyses? Some clarity on how the random effects used (described as a random intercept and random slope for matched pairs for the logistic, mixed-effects model) relates to random effect for the included studies would also be helpful.

[Correspondence] Multidrug-resistant tuberculosis

Thu, 25 Jul 2019 23:00:09 +0000

The ideal number of drugs needed and treatment duration are crucial issues in the management of multidrug-resistant tuberculosis (MDR-TB). Thus, we read with interest the Article by the Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017,1 the results of which support our proposal,2 from 2015, to classify anti-tuberculosis drugs on the basis of their toxicity, and sterilising or bactericidal activity.

[Correspondence] Preparing for emerging infections means expecting new syndemics

Thu, 25 Jul 2019 23:00:09 +0000

When several sources of morbidity come together to produce interlinked and worse health outcomes, they are sometimes called a syndemic. Research on syndemics explores how two or more diseases cluster together; how social, political, economic, and ecological factors drive those clusters; and how clustered conditions interact via biological, psychological, or social pathways.1 Syndemic interventions target underlying patterns of multidirectional causality to achieve better overall health in susceptible and often dispossessed populations.

[Obituary] Kenneth Forde

Thu, 25 Jul 2019 23:00:09 +0000

Surgeon and pioneer in diagnostic and surgical endoscopy. Born on July 6, 1933, in Manhattan, NY, USA, he died of heart failure on June 2, 2019, in Scarborough, NY, USA, aged 85 years.

[Perspectives] Trailblazing women in medicine: laurels at last for Edinburgh Seven

Thu, 25 Jul 2019 23:00:08 +0000

On Nov 18, 1870, seven women arrived at the Surgeons' Hall in Edinburgh, UK, to sit their anatomy exams. They were met by a baying mob of youths—many of them fellow medical students—who pelted them with mud, shouted obscenities, and blocked the gates. After a sympathetic student let them through, the women sat their exams while the protestors yelled outside. At one point, a live sheep was thrust into the room. The “Surgeons' Hall riot”, as it was dubbed, was probably the lowest point in a 4-year campaign aimed at preventing the seven women from completing their medical degrees at the University of Edinburgh.

[Perspectives] Eleanor Crook: master of morbid sculpture

Thu, 25 Jul 2019 23:00:08 +0000

Guy the Gaunt, very likely the first Transi, or cadaver tomb, to be sculpted in over 400 years, is slowly, eerily emerging from a long block of limewood, carved chip by chip by Eleanor Crook since 2014. Guy's anatomically accurate, skeletal body is in the tradition of English cadaver memorials, carved out of stone or wood, dating between around 1425–1558. Christina Welch, Senior Fellow in Theology and Religious Studies at the UK's University of Winchester, led a crowd-funding campaign for the project.

[Perspectives] The public health and industry partnership conundrum

Thu, 25 Jul 2019 23:00:08 +0000

Although we hesitate to admit it, those of us who make a living in public health, be it in the academic world or in practice, have a near reflexive suspicion of working with the private sector. We come by that suspicion honestly. There is abundant research, evidence, and experience of how some industry practices have harmed the health of the public.

[World Report] Northern Ireland likely to legalise abortion

Thu, 25 Jul 2019 23:00:08 +0000

Only an unlikely turn of events could prevent this bill from coming into law; activists celebrate the move towards overturning some of the world's strictest abortion laws. Talha Burki reports.

[World Report] US Planned Parenthood leadership shake-up

Thu, 25 Jul 2019 23:00:08 +0000

The announcement came as a surprise: Leana Wen will no longer be the head of Planned Parenthood on the request of the board of directors. Susan Jaffe reports.

[World Report] Ebola outbreak declared a PHEIC, world waits for next steps

Thu, 25 Jul 2019 23:00:08 +0000

After the fourth meeting of the Emergency Committee, WHO declared the Ebola outbreak in DR Congo a Public Health Emergency of International Concern. John Zarocostas reports.

[Comment] Offline: Global health's indifference to poverty must end

Thu, 25 Jul 2019 23:00:08 +0000

Global health thrives on fashion. During the era of the Millennium Development Goals (MDGs, 2000–15), that fashion was poverty. The manifesto for the MDGs was the Commission on Macroeconomics and Health, chaired by Jeff Sachs and published in 2001. The Commission concluded that “The linkages of health to poverty reduction and to long-term economic growth are powerful, much stronger than is generally understood.” Sachs argued that the poor were more susceptible to disease and less likely to seek medical care, even when that care was urgently needed.

[Comment] Improving medication safety: focus on prescribers and systems

Thu, 25 Jul 2019 23:00:08 +0000

Health-care services around the world continue to struggle with safe and effective delivery of medication. Globally, it has been estimated that the cost associated with medication errors is US$42 billion each year.1 Patients in low-income countries lose twice as many disability-adjusted life-years due to medication-related harm than those in high-income countries.1 In England, there are an estimated 237 million medication errors annually, about half of which were administration errors with minimal or no potential for clinical harm.

[Comment] Surrogate endpoints in randomised controlled trials: a reality check

Thu, 25 Jul 2019 23:00:08 +0000

At the 24th Congress of the European Hematology Association in June, 2019, the results of the BELLINI trial, a double-blind, randomised, placebo-controlled trial of venetoclax, bortezomib, and dexamethasone versus placebo, bortezomib, and dexamethasone in patients with relapsed, refractory multiple myeloma, were presented, on which one of us (SK) is an investigator.1 Earlier, in March, 2019, the US Food and Drug Administration (FDA) had placed a hold on clinical trials of venetoclax in multiple myeloma.

[Comment] Rethinking management of neonates at risk of sepsis

Thu, 25 Jul 2019 23:00:08 +0000

Clinicians involved in the care of young infants are aware of the consequences of not administering or of delaying antibiotics in cases of bacterial sepsis. Those who have seen such cases might be quicker to prescribe antibiotics in the future, even if sepsis is a remote possibility. However, this practice is not without risks. Exposure to broad-spectrum antibiotics alters the body's microbiota, increases opportunistic infections, and promotes antimicrobial resistance (AMR), which may restrict future treatment options for the child.

[Comment] New malaria maps

Thu, 25 Jul 2019 23:00:08 +0000

In The Lancet, Katherine Battle1 and Daniel Weiss2 and colleagues present new malaria maps. These maps are the result of a considerable effort and will undoubtedly be well received by individuals interested in malaria. Several novelties and improvements from earlier versions are noticeable: the data for Plasmodium falciparum now cover the entire endemic world and include 5 km × 5 km pixel-level maps of mortality. Importantly, these are the first dynamic maps on Plasmodium vivax and for both plasmodial species; they include a time series spanning from 2000 to 2017.

[Comment] Septoplasty—a surgical or political challenge?

Thu, 25 Jul 2019 23:00:08 +0000

Septoplasty as an operation to straighten a deviated nasal septum is one of the most common surgical procedures in otorhinolaryngology. The scarcity of data on the efficacy of this intervention, as well as wide variations in use across countries worldwide, has led to intensive discussions about its plausibility. As a result, health insurance companies and plans worldwide increasingly query medical indication for septoplasty.

[Comment] How should we listen to ECHO?

Thu, 25 Jul 2019 23:00:08 +0000

For many years before the long-awaited results of the study by the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial Consortium,1 observational and laboratory studies suggested that some hormonal contraceptive methods, particularly intramuscular depot medroxyprogesterone acetate (DMPA-IM), might increase women's susceptibility to HIV acquisition.2 In ECHO, 7829 HIV-seronegative women seeking effective contraception were randomly assigned to receive DMPA-IM, a copper intrauterine device (IUD), or a levonorgestrel (LNG) implant, and followed for 18 months for incident HIV infection.

[Editorial] The slowdown in eradicating hunger

Thu, 25 Jul 2019 23:00:08 +0000

In 2015, the UN set the goal to eradicate hunger and malnutrition and to ensure nutritious food for all (Sustainable Development Goal 2) by 2030. On July 18, the Food and Agriculture Organization (FAO) and UN partners published their annual report The State of Food Security and Nutrition in the World. Following the trend from the two previous reports, the results point to the unlikelihood of achieving this goal.

[Editorial] Hopes for health from new European Commission leader

Thu, 25 Jul 2019 23:00:08 +0000

Ursula von der Leyen, the former German minister of defence, looks set to become President of the European Commission at a vital time for the European project. The rise of the populist right was unexpectedly matched by a rise in votes for liberal and green parties in the recent EU elections, making it less likely that von der Leyen will have to satisfy empowered populists during her presidency. Similarly, as it has become obvious across Europe that leaving the EU entirely is undesirable, the voices demanding a Brexit of their own have gone silent.

[Editorial] Prioritising primary care in the USA

Thu, 25 Jul 2019 23:00:08 +0000

Although the USA spends more on health care despite having worse outcomes than other high-income nations, one area where it underinvests is primary care. Research has shown that higher levels of spending on primary care lead to improved patient outcomes and lower overall health-care costs. On July 17, 2019, the Patient-Centered Primary Care Collaborative (PCPCC) issued the first report to look at primary care spending by state, including spending from across different types of payers: commercial insurance companies, government-provided insurance (Medicare and Medicaid), as well as the uninsured.

Testosterone Boosts Sexual Well-Being in Older Women

Thu, 25 Jul 2019 15:47:17 +0000

But the lack of testosterone formulations specifically designed for women is "a major treatment barrier" to addressing sexual dysfunction in this population, warn Australian researchers.
Medscape Medical News

New Oral Agent for Anemia in CKD Encouraging but Questions Remain

Thu, 25 Jul 2019 18:00:33 +0000

Twin studies support the hemoglobin-boosting effects of the first oral drug in a new therapeutic class that is showing promise for the treatment of anemia in two types of CKD patients.
Medscape Medical News

Boston Hospital Reports Disciplining of Child Abuse Skeptic

Thu, 25 Jul 2019 17:02:18 +0000

Last September, ProPublica examined Dr Michael Holick's work as an expert witness for alleged abusers. His hospital has notified Massachusetts' medical board that it restricted his privileges.
ProPublica

Docs No Less Likely to Die in Hospital Than Other Patients

Thu, 25 Jul 2019 17:34:29 +0000

According to a recent study, physicians are no more likely to avoid aggressive end-of-life care and die at home than nonphysicians.
Medscape Medical News

Juul Taps Addiction Expert as Medical Director

Thu, 25 Jul 2019 17:46:35 +0000

Dr Mark Rubinstein, known for researching youth vaping, is now executive medical officer at e-cigarettes producer Juul Labs. Juul says the hire will help reduce teen vaping. Critics see Big Tobacco tactics.
Kaiser Health News

Med School Enrollment Expands, Concern for Residency Slots Lingers

Thu, 25 Jul 2019 15:43:37 +0000

Enrollment in US medical schools has grown by 31% since 2002, but averting a physician shortage hinges on boosting the number of residency training slots.
Medscape Medical News

NIH Awards $10 Million for Acute Flaccid Myelitis Study

Thu, 25 Jul 2019 16:46:15 +0000

The University of Alabama at Birmingham will lead a multicenter natural history study of the polio-like illness that causes muscle weakness and paralysis, primarily in children.
Medscape Medical News

Med School Enrollment Expands, Concern for Residency Slots Lingers

Thu, 25 Jul 2019 15:43:37 +0000

Enrollment in US medical schools has grown by 31% since 2002, but averting a physician shortage hinges on boosting the number of residency training slots.
News Alerts

Testosterone Boosts Sexual Wellbeing in Older Women

Thu, 25 Jul 2019 15:47:17 +0000

But the lack of testosterone formulations designed specifically for women is "a major treatment barrier" to treating sexual dysfunction in this population, warn Australian researchers.
Medscape Medical News

Millions on Daily Aspirin for CV Prevention, but Probably Shouldn't Be: US Study

Thu, 25 Jul 2019 14:06:41 +0000

Recent trials argue against it, but almost a fourth of US adults 40 and older, and a much higher proportion 70 and older, may be taking low-dose aspirin for primary CV prevention despite the risks.
Medscape Medical News

Letterbox Campaign Helps Afghans Cope With Silent War of Mental Health

Thu, 25 Jul 2019 13:34:12 +0000

Hundreds of Afghans, weary of war and unsure of the future, have joined a letter-writing campaign to share their feelings with the powerful few who will decide on peace with the Taliban and, with it, the fate of their country.
Reuters Health Information

U.S. Coal Miners Discouraged by Black Lung Meeting With McConnell

Thu, 25 Jul 2019 13:37:27 +0000

A group of coal miners afflicted with black lung disease met with Senate Majority Leader Mitch McConnell on Tuesday as part of an effort to convince lawmakers to restore a higher excise tax on coal companies to help fund their medical care, but several said the meeting left them discouraged.
Reuters Health Information

Annual Test Best for Monoclonal Gammopathy of Undetermined Significance

Thu, 25 Jul 2019 13:44:19 +0000

The risk of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma appears to be inconsistent, prompting a need for annual testing, according to researchers.
Reuters Health Information

The Wildcat Gold Miners Who Get Rich Sick

Thu, 25 Jul 2019 13:44:32 +0000

A few years after coming as a teenager to this Ghanaian town to prospect for gold, Yaw Ngoha had made enough cash to marry his sweetheart and build a house with a porch, to which he would later add a flat-screen TV and satellite dish.
Reuters Health Information

High Response Rate With First Targeted Drug for Bladder Cancer

Thu, 25 Jul 2019 12:18:14 +0000

The novel targeted drug is welcomed by experts as an option in the second-line treatment of patients with metastatic bladder cancers and FGFR genetic alterations.
Medscape Medical News

Genetics to Blame for Procrastination?

Thu, 25 Jul 2019 11:23:02 +0000

Procrastination is tied to a genetic predisposition to higher dopamine levels in the brain, which promote cognitive flexibility and distraction, new research suggests.
Medscape Medical News

Горячая ванна за час до сна значительно улучшит его качество

Thu, 25 Jul 2019 17:40:21 +0000

Горячая ванна или душ за час-два перед отходом ко сну может значительно улучшить сон, показывает новое исследование. Результаты говорят, что пассивное прогревание в воде может улучшить общее время сна, медленный сон, качество сна, эффективность сна и сократить количество времени, необходимое для засыпания. Те, кто принимал теплую ванну, засыпали в среднем на 10 минут раньше.

#СТОПГЕПАТИТ: «Найти, чтобы спасти миллионы»

Thu, 25 Jul 2019 17:45:48 +0000

Пройти обследование на гепатит – это значит сохранить не только свое здоровье, но здоровье и жизнь миллионов других людей. В преддверии Всемирного дня борьбы с гепатитом, 27 и 28 июля любой человек сможет бесплатно пройти исследование на наличие вируса гепатита В и С (HBsAg и Anti-HCV) в медицинских офисах Центра молекулярной диагностики ЦНИИ Эпидемиологии Роспотребнадзора.

In a Disease of Aging, Patients in Trials Get Younger and Younger

Thu, 25 Jul 2019 10:40:50 +0000

Randomized clinical trials in oncology have participants who are substantially younger on average than typical real-world patients, which may limit the applicability of findings.
Medscape Medical News

Systolic, Diastolic BP Both Contribute to Cardiovascular Risk

Thu, 25 Jul 2019 10:46:21 +0000

A new analysis of more than 36 million blood pressure measurements from 1.3 million people confirms that both values are important contributors to CV risk, and that in general lower is better.
Medscape Medical News

FDA OKs First-Ever Nasal Glucagon for Severe Hypos in Diabetes

Thu, 25 Jul 2019 07:26:41 +0000

Product is expected to facilitate emergency treatment of patients with diabetes with severe hypoglycemia.
FDA Approvals

Ученые рассказали об успешных инновациях при лечении маршала Жукова от инсульта

Thu, 25 Jul 2019 10:32:01 +0000

Российские ученые рассказали об одном из первых случаев тромболитической терапии, который был проведен более 50 лет назад. Пациентом был маршал СССР Георгий Жуков, группой врачей руководил Евгений Чазов. Клинический случай опубликован в European Heart Journal. Ранее о нем было известно только их мемуарных записей.

Testosterone Therapy Paradox? CV Events Up, Mortality Down

Wed, 24 Jul 2019 18:29:46 +0000

New research in more than 15,000 middle-aged and older British men suggests testosterone therapy may reduce the risk for death, despite an uptick in the risks for stroke and MI.
Medscape Medical News

Do You Mourn Your Patients?

Wed, 24 Jul 2019 16:01:11 +0000

Stoicism protects clinicians less than they think.
Medscape Reader Polls

MDs Still Not Getting the Message About Opioids for Migraine

Wed, 24 Jul 2019 16:06:40 +0000

Despite the opioid epidemic, warnings from headache specialists, and advisories from medical societies, opioids are still overprescribed in the US.
Medscape Medical News

Overweight, Obesity in 'Early Old Age' Tied to Cortical Thinning

Wed, 24 Jul 2019 16:12:31 +0000

Greater BMI and waist circumference in a person's mid-60s are associated with thinning of the brain's cerebral cortex, especially in early old age, new research suggests.
Medscape Medical News

In Smokers, PAD Risk Climbs Faster Than CHD, Stroke Risks

Wed, 24 Jul 2019 15:31:41 +0000

Is smoking's effect on peripheral artery disease underappreciated? It was twice as strongly associated with PAD risk as with either coronary heart disease or stroke risk in a cohort study.
Medscape Medical News

Antihistamines May Help Some Patients With Chronic Diarrhea

Wed, 24 Jul 2019 15:32:28 +0000

A recent case series shows antihistamines can be used to successfully manage some patients with idiopathic postprandial diarrhea associated with dermatographia and/or chronic urticaria.
Medscape Medical News

Persistent Opioid Use Common After Gynecologic Surgery

Wed, 24 Jul 2019 14:07:32 +0000

Six in 10 women who undergo gynecologic surgery will be prescribed an opioid for the first time, and almost 7% of these women will develop persistent opioid use, new research shows.
Reuters Health Information

Daily Cannabis Use Before and During Pregnancy Rising in Northern California

Wed, 24 Jul 2019 14:21:08 +0000

Self-reported cannabis use before and during pregnancy has been rising in Northern California, with daily use increasing most rapidly, researchers say.
Reuters Health Information

Non-Continuous Care After TAVR Tied to Poorer Outcome

Wed, 24 Jul 2019 14:28:07 +0000

Patients readmitted within three months of transcatheter aortic-valve implantation/replacement (TAVI/TAVR) to a site other than that providing the implant are at increased risk of one-year mortality, according to a study of registry data.
Reuters Health Information

Brazil Approves Rules for Pesticides Easing Toxicity Criteria

Wed, 24 Jul 2019 14:43:06 +0000

Brazil's health surveillance agency, Anvisa, approved on Tuesday new rules for pesticides, establishing the risk of death as the sole criteria for classifying the toxicity level of a product.
Reuters Health Information

Short-Term Opioids for Pain Still Come With Side Effects

Wed, 24 Jul 2019 14:43:24 +0000

Patients who only briefly take opioid painkillers are still likely to face side effects, a new study shows.
Reuters Health Information

Medicare-for-All Might Not Cause Surge in Hospital Use

Wed, 24 Jul 2019 14:35:36 +0000

Medicare-for-all and other versions of universal coverage being proposed for the U.S. by several presidential hopefuls wouldn't necessarily lead more people to seek hospital care, a new analysis suggests.
Reuters Health Information

Genetics Play Bigger Role in Autism Risk Than Environmental Factors

Wed, 24 Jul 2019 14:35:14 +0000

Most of the variation in risk for autism may be explained by genetics rather than differences in environmental factors like lifestyle or community characteristics or certain pregnancy outcomes, a study in five countries suggests.
Reuters Health Information

Merck's Biosimilar to AbbVie's Humira Wins FDA Approval

Wed, 24 Jul 2019 14:27:04 +0000

The U.S. Food and Drug Administration approved Merck & Co Inc's biosimilar to AbbVie Inc's blockbuster rheumatoid arthritis treatment Humira (adalimumab), the health agency said on Tuesday.
FDA Approvals

Increased Use of CT Scans During Pregnancy in US and Canada

Wed, 24 Jul 2019 14:26:27 +0000

Over 2 decades, rates of exposure to ionizing radiation from medical imaging increased among pregnant women in the US and Canada; rates of MRI are increasing and have surpassed CT rates.
Medscape Medical News

Arm Implant to Prevent HIV Emerging

Wed, 24 Jul 2019 14:42:59 +0000

The new 'fit it and forget it' approach to HIV prevention could help people who have a hard time adhering to treatment.
Medscape Medical News

New Brain Scans Add to Controversy Over Reported Illness at U.S Embassy in Cuba

Wed, 24 Jul 2019 13:31:59 +0000

Advanced brain scans of U.S. Embassy employees who reported feeling ill while serving in Havana show the workers don't have the same amount of white matter and have different patterns of neural connections than a comparison group of people who did not work in Cuba, researchers at the University of Pennsylvania reported Tuesday.
Reuters Health Information

Coal Miners to Urge U.S. Congress to Protect Their Black Lung Benefits

Wed, 24 Jul 2019 13:36:26 +0000

Around 120 coal miners with black lung disease were due in Washington on Tuesday hoping to pressure Congress to restore a higher excise tax level on coal companies to help fund their medical care, as rates of the progressive respiratory disease rise in parts of Appalachia.
Reuters Health Information

USPSTF Reaffirms Need for HBV Screening in All Pregnant Women

Wed, 24 Jul 2019 13:40:02 +0000

All pregnant women should continue to be screened for hepatitis B virus (HBV) infection at their first prenatal visit, the U.S. Preventive Services Task Force (USPSTF) said in an updated recommendation statement.
Reuters Health Information

Романтические отношения ослабляют влияние генетической предрасположенности к алкоголизму

Wed, 24 Jul 2019 19:17:18 +0000

Согласно новому исследованию ученых из Университета Содружества Виргинии, люди с генетической предрасположенностью к алкоголизму реже пьют и реже страдают от алкогольной интоксикации и симптомов алкогольной зависимости, если они находятся в романтических отношениях. Результаты опубликованы в журнале Addiction.

Самый популярный заменитель сахара может оказаться опасным для здоровья

Wed, 24 Jul 2019 19:33:09 +0000

Достаточные доказательства безопасности потребления в пищу самого распространенного в мире искусственного подсластителя отсутствуют, утверждается в статье исследователей из Сассекского университета, опубликованной в Archives of Public Health.

Sexual, Gender Minorities Report More Subjective Cognitive Decline

Wed, 24 Jul 2019 12:00:05 +0000

Compared with heterosexual subjects, those who identify as a sexual or gender minority are almost 30% more likely to report frequent confusion or memory loss.
Medscape Medical News

Allergan Pulls Textured Breast Implants in US and Worldwide

Wed, 24 Jul 2019 12:09:04 +0000

The recall comes after an increase in reports of breast implant-associated anaplastic large cell lymphoma; the FDA says 573 unique cases and 33 deaths have been reported worldwide.
News Alerts

'Apple' Body Shape a Mortality Risk Even With Normal BMI

Wed, 24 Jul 2019 11:00:14 +0000

Apple vs pear vs olive-on-a-stick: the "scale is not everything." New study underscores the importance of waist circumference for mortality risk even when weight is normal, extends prior observations.
Medscape Medical News

Global Recall for Maquet/Datascope Intra-aortic Balloon Pumps

Wed, 24 Jul 2019 11:19:03 +0000

The devices had been previously flagged by the US Food and Drug Administration because of reports of battery failure and patient deaths dating back to 2016.
News Alerts

Restless REM Sleep May Contribute to Mood, Anxiety Disorders

Wed, 24 Jul 2019 10:33:15 +0000

The amygdala usually calms down during REM sleep, which reduces next-day distress. However, restless REM impedes this process and may possibly contribute to mood and anxiety disorders.
Medscape Medical News

Novel Agent May Ease Circadian Rhythm Disorder in Alzheimer's

Wed, 24 Jul 2019 10:34:33 +0000

An investigational agent may help regulate sleep cycles in Alzheimer's patients with irregular sleep-wake rhythm disorder.
Medscape Medical News

В РФ появятся клинические рекомендации по использованию полученных методом 3D-печати изделий

Wed, 24 Jul 2019 11:00:03 +0000

Для их разработки Ассоциация специалистов по 3D печати в медицине создала специальную рабочую группу. Сегодня травматология-ортопедия занимает второе место в мире по объему использования индивидуальных медицинских изделий 3D-печати после стоматологии. В настоящее время под наблюдением находятся около 900 пациентов, при лечении которых применялись аддитивные технологии.

HIV Drug Heightens Birth Defect Risk if Taken During Conception

Wed, 24 Jul 2019 00:02:24 +0000

The AIDS drug dolutegravir poses a small but significant risk of causing neural-tube defects for newborns when HIV-infected mothers are taking the drug when they conceive, according to surveillance data from hospitals throughout Botswana.
Reuters Health Information

School-Aged Children Commonly Take Melatonin for Sleep Problems

Tue, 23 Jul 2019 23:53:47 +0000

School-aged children commonly take melatonin to treat sleep problems, according to findings from the Generation R Study in the Netherlands.
Reuters Health Information

Antibiotic Use Without Prescription Common in US

Tue, 23 Jul 2019 23:49:24 +0000

Many people in the U.S. take antibiotics that weren't prescribed for them, according to a new meta-analysis.
Reuters Health Information

In Very Elderly, Intense Lipid-Lowering Worked in IMPROVE-IT

Tue, 23 Jul 2019 17:17:45 +0000

The post-hoc analysis addresses a gap in the literature, said an expert observer: statin plus ezetimibe safely cut clinical risk in post-ACS patients aged > 75 compared with statin monotherapy.
Medscape Medical News

Nursing Home Residents Often Have Preventable Complications After Hospital Stay

Tue, 23 Jul 2019 18:42:46 +0000

Many nursing home residents who are hospitalized develop preventable health problems after they go back to the nursing facilities, a new study suggests.
Reuters Health Information

Multidrug-Resistant Malaria Spreading in Southeast Asia -Study

Tue, 23 Jul 2019 18:09:48 +0000

Malaria parasites resistant to two key anti-malarial medicines are becoming more dominant in Vietnam, Laos and northern Thailand after spreading rapidly from Cambodia, scientists warned on Monday.
Reuters Health Information

In Very Elderly, Intense Lipid-Lowering Worked in IMPROVE-IT

Tue, 23 Jul 2019 17:17:45 +0000

Post-hoc analysis found statin plus ezetimibe safely cut clinical risk in post-ACS patients aged 75 years or older compared with statin monotherapy, said an expert observer.
Medscape Medical News

Senate Passes Bill to Replenish 9/11 Compensation Fund

Tue, 23 Jul 2019 17:39:51 +0000

The Senate approved a free flow of funds to pay claims related to lost wages and pain and suffering from illnesses linked to 9/11. The bill now goes to President Trump for his signature.
Medscape Medical News

Congo Minister's Resignation Over Ebola Snub Could Unblock New Vaccine

Tue, 23 Jul 2019 16:34:12 +0000

Congo's health minister resigned on Monday after being stripped of responsibility for managing the country's Ebola outbreak, potentially paving the way for the introduction of a second vaccine to contain the spreading epidemic.
Reuters Health Information

FDA Approval of First Digital Pill Based on 'Weak Evidence'

Tue, 23 Jul 2019 16:46:39 +0000

A review of the data that led to the FDA approval of digital aripiprazole suggests the evidence is weak and raises concerns about technology-enhanced products to 'evergreen' drugs going off patent.
Medscape Medical News

U.S. Senators Announce Bipartisan Proposal to Lower Drug Prices

Tue, 23 Jul 2019 16:13:58 +0000

The top Republican and Democrat on the U.S. Senate Finance Committee announced a proposal to lower prescription drug prices on Tuesday that could save $100 billion in costs to government healthcare programs, and said the committee would vote on the legislation on Thursday.
Reuters Health Information

Are Rising Temperatures Affecting Fetal Development?

Tue, 23 Jul 2019 15:26:50 +0000

Extreme temperatures have been associated with several negative fetal health outcomes, and the largest study to date reinforces that link.
Medscape Medical News

Вегетарианские диеты снижают риск развития сахарного диабета

Tue, 23 Jul 2019 17:55:43 +0000

Диета на растительной основе может значительно снизить риск развития диабета 2 типа. Тем не менее, не все вегетарианские диеты одинаково полезны, поэтому для снижения риска развития диабета ученые рекомендуют избегать сахара, рафинированной белой муки и переработанных продуктов.

Большое количество людей принимает аспирин без медицинских показаний

Tue, 23 Jul 2019 18:51:50 +0000

Почти 30 миллионов взрослых американцев без сердечно-сосудистых заболеваний в возрасте 40 лет и старше принимали низкие дозы аспирина для профилактики этих заболеваний в 2017 году. Причем каждый пятый делал это без рекомендации врача, согласно исследованию Гарвардского медицинского центра Дьяконицы Бет Исраэль, опубликованному в Annals of Internal Medicine.

U.S. Records 25 New Measles Cases as Outbreak Spread to Ohio, Alaska

Tue, 23 Jul 2019 11:42:33 +0000

The United States recorded 25 new measles cases last week, bringing the total number of cases in the year to 1,148 as the country recorded its worst outbreak of the disease since 1992, federal health officials said on Monday.
Reuters Health Information

Filgotinib Effective in Refractory RA, Study Finds

Tue, 23 Jul 2019 11:00:28 +0000

Patients with refractory rheumatoid arthritis who took filgotinib were more likely to achieve a clinical response at week 12 than were patients who took placebo, but long-term safety and efficacy are unclear.
Medscape Medical News

Stroke Prevention Best Path to Dementia Reduction, Experts Say

Tue, 23 Jul 2019 10:29:52 +0000

A global initiative aims to get neurology experts working together to reduce the incidence of stroke in order to reduce dementia.
Medscape Medical News

Why Do Doctor-Senators Object to the 9/11 Compensation Bill?

Tue, 23 Jul 2019 06:34:06 +0000

The Senate may soon pass a bill that would allow unrestricted federal spending to pay claims from the 9/11 Victim Compensation Fund.
Medscape Medical News

Остеоартрит увеличивает риск тяжелых болезней сердца

Tue, 23 Jul 2019 07:16:34 +0000

Ученые связали остеоартрит с существенным увеличением риска болезней сердца. Авторы указывают, что эта проблема возникает из-за вынужденной гиподинамии в результате боли в суставах. Исследование было опубликовано в журнале Osteoarthritis and Cartilage.

'High-Intensity' Telemedicine Curbs ED Use in Dementia Patients

Mon, 22 Jul 2019 16:55:56 +0000

A comprehensive telemedicine program proved effective in reducing emergency department visits in people with dementia in senior living communities.
Medscape Medical News

Edwards Warns of Balloon Burst Risk With Sapien 3 Ultra

Mon, 22 Jul 2019 16:07:21 +0000

Reports suggest a low risk of burst balloons during implantation of the TAVR system, but it has prompted a type 1 recall in Canada.
News Alerts

Гены, связанные с болезнью Альцгеймера, могут ухудшать работу мозга в юном возрасте

Mon, 22 Jul 2019 22:16:09 +0000

Ген, связанный с болезнью Альцгеймера, начинает оказывать влияние на когнитивное здоровье гораздо раньше, чем предполагалось – еще до взросления, согласно новому исследованию, проведенному учеными Калифорнийского университета и опубликованному в Neurobiology of Aging.

American College of Surgeons Releases Standards for Surgical Care of Older Adults

Mon, 22 Jul 2019 14:01:37 +0000

The American College of Surgeons (ACS) has introduced a new surgical quality improvement program for hospitals that aims to promote high-quality surgical care for older adults.
Reuters Health Information

Pets May Help Older Adults Manage Chronic Pain

Mon, 22 Jul 2019 13:57:27 +0000

People with pets may be able to use their companion animals to practice techniques for managing chronic pain without medication, researchers say.
Reuters Health Information

Physician Counseling After HIV Diagnosis Could Stem Epidemic

Mon, 22 Jul 2019 14:46:58 +0000

Authorities in the United States are using genetic tests to trace the path of HIV through communities, and physicians are helping marginalized patients understand what this means for them.
Medscape Medical News

Out-of-Pocket Costs May Curb ARNI Use Among Medicare Recipients

Mon, 22 Jul 2019 13:34:43 +0000

High out-of-pocket costs may be hindering the use of sacubitril/valsartin, an angiotensin receptor-neprilysin inhibitor (ARNI) with a known mortality benefit for those with heart failure with reduced ejection fraction, researchers say.
Reuters Health Information

Indoor Smoking Ban Tied to Heart Attack Decline in Older Adults

Mon, 22 Jul 2019 13:30:42 +0000

Heart attack rates dropped among older adults in Scotland in the decade after a nationwide indoor smoking ban took effect, a new study suggests.
Reuters Health Information

FDA OKs Apremilast (Otezla) for Oral Ulcers of Behcet's Disease

Mon, 22 Jul 2019 13:14:35 +0000

The oral phosphodiesterase-4 inhibitor is the first FDA approval for this indication.
FDA Approvals

Intestinal Fibrosis in IBD Hard to Diagnose, Treat

Mon, 22 Jul 2019 12:23:45 +0000

Intestinal fibrosis in patients with inflammatory bowel disease (IBD) is challenging to diagnose, and there are no approved antifibrotic therapies, according to a meeting summary.
Reuters Health Information

Intranasal Lorazepam Quickly Calms Agitated Child in ED

Mon, 22 Jul 2019 12:12:11 +0000

A kicking, spitting and struggling 7-year-old boy rapidly became cooperative following emergency department (ED) intranasal administration of lorazepam, according to a case report in the Annals of Emergency Medicine.
Reuters Health Information

Gum Disease Bacteria a Novel Treatment Target for Alzheimer's?

Mon, 22 Jul 2019 11:58:03 +0000

Early studies point to Porphyromonas gingivalis, the bacteria linked to periodontal disease, as a possible causal culprit in Alzheimer's disease.
Medscape Medical News

Osteoporosis Dilemma: Denosumab or Teriparatide After Bisphosphonates

Mon, 22 Jul 2019 11:34:49 +0000

For osteoporosis patients on bisphosphonates for more than a year, switching to teriparatide rather than denosumab should be done with caution, especially for those at high risk of hip fracture, although denosumab has risks of its own, researchers say.
Reuters Health Information

Some Women Don't Heed Warnings of Acne Drug Danger During Pregnancy Conception

Mon, 22 Jul 2019 11:41:36 +0000

It's long been known that the highly effective acne medication isotretinoin is tied to the risk of severe birth defects. But even with a special program in place to prevent conception in women taking the drug, each year 200 to 300 women in the U.S. become pregnant while taking it, a new study shows.
Reuters Health Information

'More Plants, Less Meat, Less Diabetes,' New Analysis Indicates

Mon, 22 Jul 2019 11:00:14 +0000

People whose diet included more versus fewer nutrient-rich plant-based foods had a 30% lower risk of developing type 2 diabetes in a new meta-analysis.
Medscape Medical News

FDA Approves First Lyrica Generics

Mon, 22 Jul 2019 11:40:21 +0000

The US FDA has approved multiple applications for the first generics of pregabalin (Lyrica) for the management of neuropathic pain.
FDA Approvals

Ученые рассказали, почему психически нездоровых людей больше болезней и выше риск смерти

Mon, 22 Jul 2019 17:17:21 +0000

Во всем мире люди с психическими заболеваниями умирают в среднем на 20 лет раньше других людей. В новом исследовании ученых Манчестерского университета, опубликованном в журнале Lancet, говорится, что правительства и медики должны обратить внимание на эту проблему.

PPIs Appear Largely Safe in Multiyear Trial

Mon, 22 Jul 2019 06:45:32 +0000

Proton pump inhibitors were not associated with any adverse event when used for three3 years, except for an increased risk for enteric infections, new findings show.
Medscape Medical News

Недержание мочи: препараты, физиотерапия, тренировки, операции

Mon, 22 Jul 2019 11:10:09 +0000

Нередко после родов женщина сталкивается с проблемой недержания мочи. По статистике, в той или иной степени от этого страдает каждая пятая женщина в возрасте 35–45 лет. С возрастом их становится больше. Чаще всего недержание мочи происходит из-за опущения тазовых органов, которое объясняется слабостью соединительной ткани. А лишний вес и хронические болезни усугубляют проблему.

Bankrupt Hospital Leaves Physicians, Nurses in the Lurch

Fri, 19 Jul 2019 11:42:03 +0000

The impending closure of Hahnemann University Hospital in Philadelphia is sending shockwaves not only through its clinicians but through the wider community, too.
Medscape Medical News

Disturbed Eating Behaviors Linked to Worse Self-Management in Type 1 Diabetes

Sat, 20 Jul 2019 16:03:03 +0000

Disturbed eating behaviors (DEB) in adolescents and emerging adults with type 1 diabetes transitioning to adult care are associated with worse diabetes self-management, according to a longitudinal study.
Reuters Health Information

Young Men 'Benefit' in Later Years When Teen Pregnancy Ends in Abortion

Sat, 20 Jul 2019 15:48:59 +0000

When young women use abortion services, the adolescent men who avoid becoming teenaged fathers go on to have better educational and financial futures than peers who do become teen fathers, a U.S. study suggests.
Reuters Health Information

Recent Cannabis Use Tied to Memory Deficits, Slowed Mental Processing

Fri, 19 Jul 2019 19:58:54 +0000

People who have recently used cannabis may be more likely to experience memory deficits or difficulties with cognitive function than those who don't use the drug, a recent study suggests.
Reuters Health Information

Women Doctors Skip Conferences Because of Family Responsibilities

Fri, 19 Jul 2019 19:41:01 +0000

Female oncologists are more likely than their male colleagues to skip scientific meetings that could offer networking opportunities and a chance to catch up with the latest developments in their field, a new study finds.
Reuters Health Information

Night Shifts, Long Hours Linked to Miscarriages and Preterm Births

Fri, 19 Jul 2019 19:04:24 +0000

Pregnant women who work nights or long hours may be more likely to have a miscarriage or preterm delivery than mothers with day jobs, a research review suggests.
Reuters Health Information

Medicare Shared Savings Program Stays Stable Despite More Risk

Fri, 19 Jul 2019 17:46:57 +0000

Providers are more willing to take on financial risk than some expected, CMS chief says, but critics of the program are still expressing concerns.
Medscape Medical News

Health Insurers Make It Easy for Scammers to Steal Millions

Fri, 19 Jul 2019 17:00:51 +0000

Health insurers are regarded as fierce defenders of health care dollars. But the case of David Williams shows one reason America's health care costs continue to rise. The personal trainer spent years posing as a doctor and billing the nation's top insurers, making off with millions.
ProPublica

Epithelial Response to Butyrate Diminished in Active IBD

Fri, 19 Jul 2019 16:38:11 +0000

The epithelial response to butyrate in patients with inflammatory bowel disease (IBD) is diminished, but only in the presence of tumor necrosis factor alpha (TNFalpha), researchers from Spain report.
Reuters Health Information

От предотвратимых медицинских ошибок страдает 1 из 20 пациентов

Fri, 19 Jul 2019 22:20:45 +0000

Приблизительно один из 20 (6%) пациентов при оказании медицинской помощи страдает от врачебной ошибки, которой можно было избежать. У 12% из этих пациентов развивается пожизненная инвалидность или наступает смерть. Об этом свидетельствуют данные нового исследования, опубликованного в British Medical Journal.

Ученые: Кофе не влияет на риск развития рака

Fri, 19 Jul 2019 22:30:30 +0000

Новое исследование австралийского медицинского научно-исследовательского института QIMR Berghofer обнаружило, что ежедневное употребление кофе не уменьшает и не увеличивает риск развития рака у человека. Результаты опубликованы в International Journal of Epidemiology.

AI Predicts Long-term Death Risk From Single Chest X-ray

Fri, 19 Jul 2019 15:35:29 +0000

Using a single diagnostic image, a new artificial intelligence algorithm predicts 12-year mortality, new data suggested.
Medscape Medical News

Brain 'Go and Stop' Response May Hone ADHD Diagnosis in Kids

Fri, 19 Jul 2019 15:47:03 +0000

The ability to start and delay a task differs significantly between kids with attention deficit-hyperactivity disorder and typically developing children, new research suggests.
Medscape Medical News

New Guidance on Antipsychotic Choice

Fri, 19 Jul 2019 11:56:43 +0000

Choosing the best antipsychotic for individual patients with schizophrenia is challenging. A new meta-analysis seeks to inform that choice by ranking 32 antipsychotics on the basis of efficacy and safety.
Medscape Medical News

Frequent Sleeping Pill Use Linked to Increased Dementia Risk

Fri, 19 Jul 2019 12:22:26 +0000

Adults who reported taking sleep meds 5 or more nights per month had a 43% greater risk of developing dementia over 15 years vs their peers who rarely took sleeping pills.
Medscape Medical News

EINSTEIN-Jr: Rivaroxaban Safe, Effective in Kids With VTE

Fri, 19 Jul 2019 10:36:56 +0000

Billed as the largest-ever randomized trial of venous thromboembolism management in children, it suggests the direct oral anticoagulant works as well for them as for adults, say investigators.
Medscape Medical News

'Striking' Benefit of Intranasal Insulin in Slowing Dementia

Fri, 19 Jul 2019 11:32:11 +0000

Extension trial showed striking results at 18 months in patients with mild cognitive impairment or dementia using a particular insulin delivery device.
Medscape Medical News

Uncertain Future for Physicians, Nurses at Bankrupt Hospital

Fri, 19 Jul 2019 11:42:03 +0000

The impending closure of Hahnemann University Hospital in Philadelphia is sending shockwaves not only through its clinicians but through the wider community, too.

Could Cheap Drug Metformin Prevent Dementia in Black Patients?

Fri, 19 Jul 2019 08:52:34 +0000

African American patients with diabetes started on metformin showed a marked reduction in dementia compared with those on a sulfonylurea, with the 50-64 year age group showing a 40% risk reduction.
Medscape Medical News

Начало лечения инсульта на 15 минут раньше может спасти жизнь и предупредить инвалидность

Fri, 19 Jul 2019 08:47:01 +0000

Новое американское исследование, опубликованное в JAMA Network, показало, что если инсульт начинать лечить на 15 минут раньше, то это значительно улучшит исход болезни. Группа ученых пыталась определить связь между временем начала реперфузионной терапии и результатами лечения у пациентов острым ишемическим инсультом.

[Series] Ending the neglect of global oral health: time for radical action

Thu, 18 Jul 2019 23:00:09 +0000

Oral diseases are a major global public health problem affecting over 3·5 billion people. However, dentistry has so far been unable to tackle this problem. A fundamentally different approach is now needed. In this second of two papers in a Series on oral health, we present a critique of dentistry, highlighting its key limitations and the urgent need for system reform. In high-income countries, the current treatment-dominated, increasingly high-technology, interventionist, and specialised approach is not tackling the underlying causes of disease and is not addressing inequalities in oral health.

[Series] Oral diseases: a global public health challenge

Thu, 18 Jul 2019 23:00:09 +0000

Oral diseases are among the most prevalent diseases globally and have serious health and economic burdens, greatly reducing quality of life for those affected. The most prevalent and consequential oral diseases globally are dental caries (tooth decay), periodontal disease, tooth loss, and cancers of the lips and oral cavity. In this first of two papers in a Series on oral health, we describe the scope of the global oral disease epidemic, its origins in terms of social and commercial determinants, and its costs in terms of population wellbeing and societal impact.

[Clinical Picture] Avoid making a mountain out of an invasive hydatidiform mole: do a pregnancy test!

Thu, 18 Jul 2019 23:00:09 +0000

A 28-year-old Egyptian woman was referred to our specialised gestational trophoblastic disease clinic for treatment. She explained that 2 years earlier, her menstrual cycle had changed and become irregular with prolonged heavy bleeding lasting between 15 and 20 days; before this, her periods had been regular, lasting 30 days with 5 days of bleeding. The woman had two children and no history of contraceptive use, hormonal therapy, or any other medications. 3 months after the irregular bleeding started, the patient visited her local gynaecologist, who reported no uterine or cervical disease and prescribed diosmin tablets.

[Articles] New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis

Thu, 18 Jul 2019 23:00:09 +0000

The burden of mental disorders is high in conflict-affected populations. Given the large numbers of people in need and the humanitarian imperative to reduce suffering, there is an urgent need to implement scalable mental health interventions to address this burden.

[Articles] Drug-coated balloon for treatment of de-novo coronary artery lesions in patients with high bleeding risk (DEBUT): a single-blind, randomised, non-inferiority trial

Thu, 18 Jul 2019 23:00:09 +0000

The optimal technique of percutaneous coronary intervention in patients at high bleeding risk is not known. The hypothesis of the DEBUT trial was that percutaneous coronary intervention with drug-coated balloons is non-inferior to percutaneous coronary intervention with bare-metal stents for this population.

[Articles] An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial

Thu, 18 Jul 2019 23:00:09 +0000

Sphenopalatine ganglion stimulation is safe for patients with acute ischaemic stroke 8–24 h after onset, who are ineligible for thrombolytic therapy. Although not reaching significance, the trial's results support that, among patients with imaging evidence of cortical involvement at presentation, sphenopalatine ganglion stimulation is likely to improve functional outcome.

[Department of Error] Department of Error

Thu, 18 Jul 2019 23:00:09 +0000

Rissanen TT, Uskela S, Eränen J, et al. Drug-coated balloon for treatment of de-novo coronary artery lesions in patients with high bleeding risk (DEBUT): a single-blind, randomised, non-inferiority trial. Lancet 2019; 394: 230–39—The appendix of this Article has been corrected as of June 24, 2019.

[Department of Error] Department of Error

Thu, 18 Jul 2019 23:00:09 +0000

Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet 2008; 372: 2023–30—In this Article, the first sentence of the figure 3 legend should read, “Brown staining represents MHC II at low (A,C,E) and high magnification (B,E,F)” and the final sentences should read, “At implantation, only a few small areas of cartilage were weakly MHC II positive. No Class I staining was visible (images not shown)”. These corrections have been made to the online version as of July 18, 2019.

[Department of Error] Department of Error

Thu, 18 Jul 2019 23:00:08 +0000

Cubaka VK, Schriver M, Uwizihiwe JP, Lygidakis C, Kallestrup P. The twin-PhD model contributes to knowledge production in Africa. Lancet 2019; 393: 2590—The title of this Correspondence contained a spelling mistake in the word “contributes”. This correction has been made to the online version as of July 1, 2019.

[Correspondence] Closing the Aboriginal health gap

Thu, 18 Jul 2019 23:00:08 +0000

It is proper for your columns to express disappointment at the dismal results of the decade-long national Close the Gap Strategy directed towards giving Indigenous and non-Indigenous Australians equity in social wellbeing, including health.1 But it is naïve and misleading to blame the continuing failures on governmental hypocrisy and lip service.

[Correspondence] When can heart failure treatment be stopped safely? – Authors' reply

Thu, 18 Jul 2019 23:00:08 +0000

We thank Jennifer Thibodeau and Mark Drazner for their comments. As experienced clinicians, it is probable they have cared for patients with dilated cardiomyopathy who have made a full symptomatic recovery with apparent normalisation of cardiac function. Such patients frequently ask whether heart failure treatments can be stopped. What should we tell such patients? We do not think that anecdotes are the optimal basis for advising on treatment. Data from randomised trials provide objective evidence of risk and facilitate shared decision making.

[Correspondence] When can heart failure treatment be stopped safely?

Thu, 18 Jul 2019 23:00:08 +0000

Brian Halliday and colleagues1 showed that the withdrawal of pharmacological treatment in patients with recovered dilated cardiomyopathy was associated with a high rate of relapse. While the study provides support for the ongoing use of medications for these patients,2 it should be noted that the study population consisted of a heterogeneous group, with almost half (48%) on three or more heart failure medications before withdrawal. The cohort included patients with atrial fibrillation, hypertension, diabetes, familial cardiomyopathy, or truncating variant in TTN.

[Correspondence] When can heart failure treatment be stopped safely?

Thu, 18 Jul 2019 23:00:08 +0000

We have ethical concerns regarding the study by Brian Halliday and colleagues.1 As active practitioners, we have ample experience treating patients with heart failure with recovered left ventricular ejection fraction. Our experience includes individuals who stopped beta-blockers due to non-compliance or discontinuation by other health-care providers, subsequently deteriorating in their systolic function and clinical status. In the justification of the TRED-HF trial,1 the investigators provide three main arguments.

[Correspondence] Healthy diets and sustainable food systems – Authors' reply

Thu, 18 Jul 2019 23:00:08 +0000

We welcome this opportunity to engage with our colleagues' suggestions and concerns that have arisen since publishing the EAT-Lancet report on healthy diets from sustainable food systems.1

[Correspondence] Healthy diets and sustainable food systems

Thu, 18 Jul 2019 23:00:08 +0000

The EAT-Lancet Commission1 aims to define healthy global diets that avoid environmental degradation. It adopts the planetary boundaries concept to define “a safe operating space for humanity”2,3 or more prosaically “global biophysical limits that humanity should operate within to ensure a stable and resilient Earth system”.1 However, the scientific analysis is obfuscated when two boundaries (climate change and nitrogen cycling) are relaxed to accommodate the pollution that seems unavoidable with a growing and more prosperous population: the “safe operating space”2,3 by definition is expanded to accommodate the diets that the report purports to scientifically test.

[Correspondence] Healthy diets and sustainable food systems

Thu, 18 Jul 2019 23:00:08 +0000

In their report, Walter Willett and colleagues1 stated that their dietary recommendations were based on the best available science.1 Nevertheless, their prescriptions and proscriptions relied heavily upon dietary data that were found to be “meaningless”2 and a retracted study (PREDIMED).3 As such, the report contributes to the fictional discourse on diet–disease relations2,4 that began in the 1950s.4

[Correspondence] Healthy diets and sustainable food systems

Thu, 18 Jul 2019 23:00:08 +0000

We applaud the EAT-Lancet Commission1 by Walter Willett and colleagues but nonetheless take issue with their suggested ideal diet. We agree that preserving species diversity in the earth's biosphere benefits human health. We wish that the Commission had extended that assertion to the microbial species diversity in the human gut.

[Obituary] Teruko Ishizaka

Thu, 18 Jul 2019 23:00:08 +0000

Immunologist who co-discovered IgE and advanced allergy research. Born in Yamagata, Japan, on Sept 28, 1926, she died with Parkinsonism symptoms in Yamagata, Japan, on June 4, 2019, aged 92 years.

[Perspectives] Polished smiles and porcelain teeth

Thu, 18 Jul 2019 23:00:08 +0000

Perhaps the most famous set of false teeth in history rest on a brass cradle in a glass case at the Mount Vernon Estate in Virginia. In another setting, they could be a pair of castanets imagined by Francis Bacon—a ghastly, disembodied grin that might pursue you, gnashing, through your dreams. These dentures once belonged to George Washington, first President of the USA, and—as most writers on the subject have observed—they are not made of wood, but a mixture of human teeth, cow or horse teeth, and elephant ivory.

[Perspectives] Richard Watt: time to tackle oral diseases

Thu, 18 Jul 2019 23:00:08 +0000

Richard Watt first became aware of the social roots of oral health inequalities more than 30 years ago when he was a dentist at Greaves Hall psychiatric hospital in Merseyside, UK. There, he witnessed “appalling” levels of oral disease. “The mouth really is a marker of people's social position and future disease risk”, he says, “and oral diseases are a canary in the coal mine for inequality”. Today, Watt is Professor and Chair of Dental Public Health at University College London (UCL) in the Department of Epidemiology and Public Health.

[Perspectives] Taxidermy and the clinic

Thu, 18 Jul 2019 23:00:08 +0000

Derek Frampton is one of the UK's leading taxidermists. For years he was based at London's Natural History Museum and now he works freelance. Much of his work involves “setting up” animals from zoos or collections when they die. At other times, he works with museum specimens that need conservation or repair. Sometimes he recreates extinct animals, or imaginary creatures like dragons. And sometimes, he works for the sheer joy of his art.

[Perspectives] Moon landing: space medicine and the legacy of Project Apollo

Thu, 18 Jul 2019 23:00:08 +0000

On July 20, 1969, after a fraught 13 minutes of final descent, Apollo 11's commander Neil Armstrong and lunar module pilot Edwin “Buzz” Aldrin Jr made their historic first landing on the surface of the Moon. The US National Aeronautics and Space Administration (NASA) estimates that all-told 400 000 people were involved in that effort. The Project Apollo workforce had laboured tirelessly to achieve the goal set by US President John F Kennedy in 1961 of getting a human crew to the surface of the Moon and back before the end of the decade.

[World Report] The yellow fever vaccination certificate loophole in Nigeria

Thu, 18 Jul 2019 23:00:08 +0000

Nigeria has introduced an e-registry to prevent travel with counterfeit certificates. But it is still possible to obtain a government-issued certificate without vaccination. Paul Adepoju reports.

[World Report] Hysterectomies in Beed district raise questions for India

Thu, 18 Jul 2019 23:00:08 +0000

An anomalous number of hysterectomies among women working as sugarcane cutters in Beed, Maharashtra, raises suspicion of unscrupulous medical practices. Patralekha Chatterjee reports.

[World Report] Hungarian Government taking over science academy

Thu, 18 Jul 2019 23:00:07 +0000

A bill pending approval could allow the Hungarian Government to take over the Hungarian Academy of Sciences. Sharmila Devi reports.

[Comment] Offline: The ethical darkness of global health

Thu, 18 Jul 2019 23:00:07 +0000

Saudi Arabia. A country whose rulers ordered the murder and dismemberment of journalist Jamal Khashoggi. A nation whose armed forces have killed thousands of civilians in Yemen. The Philippines. A country whose President has led a violent “war on drugs”, with over 4000 extrajudicial executions since 2016. Myanmar. A nation whose abuses against the Rohingya people have been globally condemned. International action to hold Saudi Arabia, the Philippines, and Myanmar accountable has been weak. But there has, at least, been some action.

[Comment] Understanding masculinities to improve men's health

Thu, 18 Jul 2019 23:00:07 +0000

While women and girls experience more disability in every region of the world, men and boys bear a greater share of the global mortality burden. The 2016 Global Burden of Disease data show age-standardised death rates per 100 000 population of 1002 for men and 690 for women.1 Many of the drivers of men's ill-health are linked to perceptions and attitudes about manhood and the overall structural organisation of men's lives and relationships.2 Furthermore, this public health challenge is intensified by insufficient attention to the intersections between masculine norms and men's health within public health systems.

[Comment] Promoting radical action for global oral health: integration or independence?

Thu, 18 Jul 2019 23:00:07 +0000

Globally, oral health has been neglected. The major global burden of oral health and its social and economic impacts are not disputed,1 and the deficiencies in oral health care and preventive services in all countries are apparent.2 But given that everyone experiences oral health problems at some stage of their life, it is surprising that the neglect of global oral health has not been seriously challenged.

[Comment] Conflicts of interest between the sugary food and beverage industry and dental research organisations: time for reform

Thu, 18 Jul 2019 23:00:07 +0000

Prevention of dental caries (tooth decay), one of the most common chronic diseases globally,1 requires the global implementation of WHO's guideline on sugars intake.2,3 WHO recommends that individuals consume less than 10% of total energy intake from free sugars and that intake below 5% would be beneficial.3 The global dental research community, as the Lancet oral health Series1,2 argues, has an important role in the implementation of the WHO guideline by promoting research on public health and dietary interventions, among other actions.

[Comment] Guiding policy and practice to address mental disorders in conflict settings

Thu, 18 Jul 2019 23:00:07 +0000

The number of armed conflicts reached an all-time high in 2016, with 53 ongoing conflicts in 37 countries and 12% of the world's population living in an active conflict zone.1 Mental health problems are one profound consequence of conflict, and quantification of their burden is a crucial first step. Indeed, despite the inherent challenges in collecting relevant data, stakeholders have advocated for documenting the prevalence and burden of mental health problems in conflict settings as a priority in global mental health research.

[Comment] Sphenopalatine ganglion stimulation after stroke, promising but not yet ready for adoption

Thu, 18 Jul 2019 23:00:07 +0000

Despite major advances in treatment of acute ischaemic stroke with reperfusion therapies—intravenous thrombolysis and mechanical thrombectomy1,2—most patients remain ineligible for these treatments. In many centres around the world, neither mechanical thrombectomy nor advanced brain imaging to identify patients who would benefit from reperfusion therapies in a later time window is available.3,4 Alternative treatment options are needed that improve outcome irrespective of time windows and imaging-defined salvageable tissue windows.

[Editorial] A wake up call for the Ebola outbreak response

Thu, 18 Jul 2019 23:00:07 +0000

A 46-year-old pastor died from Ebola virus infection in Goma, DR Congo, this week. Nearly a year since the Ebola outbreak began, WHO convened a High-Level meeting to review the response and to call for a more system-wide coordinated approach with UN partners ahead of publication of the fourth strategic response plan (SRP4) by the government. The tone of the meeting was defiant and conveyed a definite change in narrative, at odds with those who claim the Ebola virus outbreak is under control. WHO Director-General, Tedros Adhanom Ghebreyesus, announced that he will reconvene the International Health Regulations Emergency Committee.

[Editorial] Oral health at a tipping point

Thu, 18 Jul 2019 23:00:07 +0000

What comes to mind when you think of dentistry? A luxury, a pain, excessive costs, the quest for straight, white teeth? Any way that dentistry is thought of, it's rarely as a mainstream part of health-care practice and policy, despite the centrality of the mouth and oral cavity to people's wellbeing and identity. The inattention to dental and oral health is concerning given the fact that oral diseases—tooth decay, gum disease, and oral cancers—are exceedingly common, affecting an estimated 3·5 billion people across the world.

[Editorial] Prioritising disability in universal health coverage

Thu, 18 Jul 2019 23:00:07 +0000

Current health systems are failing the 1 billion people worldwide living with disabilities. Unless access to health care is dramatically improved for this marginalised group, the goal of universal health coverage will not be achieved. These are the stark conclusions of The Missing Billion, a report from the London School of Hygiene & Tropical Medicine and other partners, published on July 9, which shines a light on the barriers to health care and disparities in outcomes faced by people living with disabilities.

'Wake Up Call': Early Adult Health May Set Path for Later CVD

Thu, 18 Jul 2019 18:03:14 +0000

"This analysis brings the field 1 step closer to the 'holy grail' of a direct link between early life exposures and cardiovascular events," experts said.
Medscape Medical News

Support for Broadening ECG Criteria for Using CRT

Thu, 18 Jul 2019 18:12:55 +0000

It might be oversimplifying to focus only on heart failure patients with left-bundle-branch block, say some. There is a non-LBBB subgroup that seems to benefit, suggest registry data.
Medscape Medical News

Menstrual Cups Safe, Effective, and Largely Unkown

Thu, 18 Jul 2019 18:51:40 +0000

Menstrual cups are at least as effective at collecting menstrual blood as sanitary pads and tampons, yet a pervasive lack of awareness of the cups hinders widespread use.
Medscape Medical News

Obstetric Care Package for Women With Opioid Use Disorder

Thu, 18 Jul 2019 17:10:33 +0000

In an effort to reduce adverse maternal and neonatal health consequences of substance use, the National Partnership for Maternal Safety has created a consensus bundle on obstetric care for women with opioid use disorder.
Reuters Health Information

Many Hospitals Not Meeting Standards for High-Risk Surgeries: Survey

Thu, 18 Jul 2019 17:10:16 +0000

Most hospitals don't perform enough surgeries to meet minimum safety standards. Three out of four also don't have systems in place to monitor whether each surgery is necessary, says watchdog group.
Medscape Medical News

New Age-Related Macular Degeneration Common in Untreated Fellow Eyes

Thu, 18 Jul 2019 16:47:50 +0000

New age-related macular degeneration (AMD) develops in about a quarter of fellow eyes to those treated for neovascular AMD with intravitreal anti-VEGF agents, according to a post hoc analysis of the VIEW 1 and VIEW 2 studies.
Reuters Health Information

Dyslipidemia, Prediabetes More Common in Youth With Down Syndrome

Thu, 18 Jul 2019 16:41:16 +0000

Children and young adults with Down syndrome (DS) have a greater prevalence of abnormal lipid levels and prediabetes compared to typically-developing youth, for the same amount of body fat, according to a study online today in Pediatrics.
Reuters Health Information

Male Victims of Domestic Violence Struggle to Disclose Abuse

Thu, 18 Jul 2019 16:29:04 +0000

Men who experience domestic violence and abuse often don't seek help until the problem becomes a crisis, researchers say.
Reuters Health Information

U.S. Women With Less Income, Education Often Lack Access to Infertility Care

Thu, 18 Jul 2019 16:07:36 +0000

Although women from all walks of life tend to experience infertility at similar rates, a new U.S. study suggests there are wide disparities in access to treatment.
Reuters Health Information

'Habit' of Workouts at Consistent Time of Day Tied to Meeting Activity Goals

Thu, 18 Jul 2019 16:03:23 +0000

People who always work out at the same time of day get more exercise overall and are more likely to get the recommended minimum amounts of weekly activity, a small U.S. study suggests.
Reuters Health Information

Many Common, Deadly Cancers Underfunded by Nonprofits

Thu, 18 Jul 2019 16:00:46 +0000

Many common, deadly cancers are underfunded by nonprofit organizations; these cancers affect parts of the body that are stigmatized, and this may be contributing, say researchers.
Medscape Medical News

Most New Drugs Show No Evidence of Added Benefit

Thu, 18 Jul 2019 16:07:17 +0000

Most new drugs entering the market have shown no added benefit over the existing standard of care, with psychiatry and neurology drugs showing the worst numbers, new research suggests.
Medscape Medical News

CVS Enters Home Dialysis Care With Clinical Trial of New System

Thu, 18 Jul 2019 15:43:32 +0000

CVS Health said on Wednesday it will start a clinical trial of its new home dialysis system this week, setting it up to compete directly with the two largest operators of U.S. dialysis centers, Fresenius Medical Care AG and DaVita Inc.
Reuters Health Information

Biden Cancer Initiative Hits 'Pause'

Thu, 18 Jul 2019 14:09:48 +0000

The organization has suspended operations while the former vice president conducts his 2020 campaign for president.
Medscape Medical News

Правительство Германии поддержало обязательную вакцинацию детей против кори

Thu, 18 Jul 2019 20:01:03 +0000

Правительство Германии поддержало законопроект, согласно которому все дети должны быть привиты от кори до поступления в школу или детский сад. Теперь родителям, которые не вакцинировали своих детей, могут грозить огромные штрафы.

Blood Biomarker Identifies Multiple Neurologic Disorders

Thu, 18 Jul 2019 11:45:30 +0000

Increased levels of neurofilament light protein can identify a number of neurodegenerative conditions with good to moderate accuracy.
Medscape Medical News

Heavy Alcohol Use May Triple Dementia Risk

Thu, 18 Jul 2019 11:14:09 +0000

Female military veterans with alcohol use disorder were three times more likely to develop dementia compared to their counterparts who did not engage in heavy alcohol use.
Medscape Medical News

Люди в два раза чаще бросают курить, когда их стимулируют материально

Thu, 18 Jul 2019 16:55:43 +0000

Новое британское исследование показывает, что финансовое стимулирование может заставить вдвое больше курильщиков бросить курить. Ученые из Норвичской медицинской школы Университета Восточной Англии изучили вопрос, насколько деньги помогают людям бросить курить, и опубликовали свои результаты в Cochrane Library.

Algorithm Could Be 'Major Leap Forward' for Pancreatic Cysts

Thu, 18 Jul 2019 10:15:31 +0000

Machine-learning trains algorithm to classify pancreatic cysts into low to high risk, potentially sparing patients' unnecessary complex surgery to remove lesions with no malignant potential.
Medscape Medical News

Alzheimer's Blood Test on the Horizon

Thu, 18 Jul 2019 10:39:30 +0000

The global race to create an inexpensive and accessible blood test for Alzheimer disease is heating up. Experts project that such a test could be available in just a few years.
Medscape Medical News

CMS Proposes New Bundled Payment Model for Radiation Oncology

Thu, 18 Jul 2019 07:56:00 +0000

CMS has proposed a new mandatory radiation oncology model, which would bundle payments for treatments that span a 90-day episode.
Medscape Medical News

Secondhand Smoke Still Endangers 20% of Nonsmokers at Work: CDC

Thu, 18 Jul 2019 06:53:32 +0000

One fifth of nonsmoking workers reported recent secondhand smoke exposure, CDC researchers found; the number of exposed workers was highest among those in the construction industry.
Medscape Medical News

Менструальные чаши оказались безопасными и эффективными

Thu, 18 Jul 2019 11:55:53 +0000

Менструальные чаши так же безопасны и эффективны, как одноразовые тампоны и прокладки, согласно первому крупному научному обзору, проведенному исследователями из Ливерпульской школы тропической медицины и опубликованному в The Lancet Public Health.

WHO Declares Ebola Outbreak is International Health Emergency

Wed, 17 Jul 2019 22:00:00 +0000

The World Health Organization declared the Ebola outbreak in Democratic Republic of Congo to be a public health emergency of international concern, saying the recent risk of its spread in the city of Goma and into Uganda had increased the threat.
Reuters Health Information

High Systolic BP Causes Valve Disease, Genetic Study Suggests

Wed, 17 Jul 2019 19:48:30 +0000

Going beyond prior observational studies, a Mendelian randomization analysis provides strong evidence that raised systolic blood pressure leads to aortic stenosis and other valve disorders.
Medscape Medical News

Biological Basis for the 'Female Advantage' in Alzheimer's

Wed, 17 Jul 2019 16:52:23 +0000

The female brain is more efficient then the male brain in the early stages of dementia, which may explain the female advantage when it comes to maintaining verbal memory.
Medscape Medical News

Universal Test and Treat Won't Stop HIV Epidemic

Wed, 17 Jul 2019 17:21:54 +0000

In recent years, 3 large studies tested the idea that scaling up HIV testing and offering treatment immediately might halt new infections. Researchers grapple with whether test-and-treat is enough.
Medscape Medical News

New Payment Plan for GA Hospital System: 25% Upfront for Some Patients

Wed, 17 Jul 2019 17:34:51 +0000

Piedmont Healthcare says the patients who will face the new charge fall into two categories: those whose are uninsured and pay for their own care and those who have insurance with high deductibles.
Georgia Health News

U.S. Overdose Deaths Post Annual Drop for First Time in Two Decades

Wed, 17 Jul 2019 17:07:32 +0000

U.S. overdose deaths dropped last year for the first time in nearly two decades, the Centers for Disease Control and Prevention said on Wednesday, in a sign that a nationwide epidemic of drug-related deaths is abating.
Reuters Health Information

AAP President-Elect Says Children Suffering in Border Facilities

Wed, 17 Jul 2019 15:55:07 +0000

Sally Goza, MD, president-elect of the American Academy of Pediatrics, who visited migrant border facilities last month, says she was alarmed by the signs of children's stress there.
Georgia Health News

FDA Clears Low-Level Laser Device for 'Whole Body' Pain

Wed, 17 Jul 2019 15:57:28 +0000

The FDA has granted marketing clearance for a low-level laser device for the treatment of "whole body" musculoskeletal pain, the manufacturer has announced.
FDA Approvals

Mothers' Work With Solvents Tied to Higher Autism Risk for Kids

Wed, 17 Jul 2019 15:38:25 +0000

Women who are exposed to solvents on the job may be more likely to have children with autism than mothers without this occupational exposure, a recent study suggests.
Reuters Health Information

Intranasal Sufentanil Effective for Acute Severe Trauma Pain

Wed, 17 Jul 2019 15:24:00 +0000

Intranasal sufentanil is as effective as intravenous morphine for treating acute severe trauma pain, according to results from a noninferiority study.
Reuters Health Information

CSF Shunt Hazard With Close Proximity to Hearing Devices

Wed, 17 Jul 2019 14:51:24 +0000

The FDA is warning healthcare providers about potential hazards associated with CSF shunts when in close proximity to implantable hearing devices that contain magnets.
News Alerts

Safety Lapses Spurred Septic Knee Arthritis Outbreak

Wed, 17 Jul 2019 12:52:59 +0000

Forty-one patients who received intra-articular injections at a private outpatient osteoarthritis clinic contracted this rare condition, an investigation showed.
Medscape Medical News

FDA Approves Drug Trio for UTI, Intra-abdominal Infection

Wed, 17 Jul 2019 12:15:12 +0000

The FDA approved the antibacterial drug trio imipenem, cilastatin, and relebactam for adults with complicated urinary tract infections and complicated intra-abdominal infections.
FDA Approvals

Working 9 to 5 May Protect Women From Memory Loss

Wed, 17 Jul 2019 12:17:44 +0000

Working women experience a slower rate of age-related memory loss than their nonworking counterparts, results of a large, longitudinal study show.
Medscape Medical News

«Цель защиты врачей от преступных посягательств, ставившаяся изначально, не достигнута»

Wed, 17 Jul 2019 18:39:25 +0000

Госдума приняла закон об ответственности за нападение на медиков при исполнении ими профессионального долга. Эта ответственность рассматривается сквозь призму гипотетического нанесения вреда пациентам: например, наказание грозит автохамам, мешающим работе Скорой помощи. Сами медики считают, что закон должен защищать их от нападений без привязки к последствиям для пациентов.

Head of U.S. Planned Parenthood Groups Departs, Cites Differences Over Abortion

Wed, 17 Jul 2019 11:07:45 +0000

The leader of reproductive services provider Planned Parenthood Federation of America and its political arm said on Tuesday that she was leaving both organizations over philosophical differences in their approaches to abortion rights.
Reuters Health Information

Is There a Difference Between Academic and Community Practice?

Wed, 17 Jul 2019 11:06:22 +0000

'I just hate the thought that they might be warring factions,' one oncologist said.
Medscape Reader Polls

Lack of Antidepressant Efficacy a Matter of Statistics?

Wed, 17 Jul 2019 11:37:29 +0000

A new study refutes claims that antidepressants are ineffective in non-severe depression and suggests reconsidering how depression rating scales are used to define severity and assess drug response,
Medscape Medical News

Ученые рассказали, почему женщины чаще страдают от болезни Альцгеймера

Wed, 17 Jul 2019 17:22:52 +0000

Одним из объяснений большей подверженности женщин болезни Альцгеймера является то, что женщины дольше живут. Сейчас ученые показали, что другими возможными причинами проблемы могут быть другой механизм распространения в нейронах белка, ответственного за развитие болезни, а также генетические и социальные факторы.

No Fracture Risk for New Diabetes Drugs in Real-World Study

Wed, 17 Jul 2019 10:11:30 +0000

Link between SGLT2 inhibitors for type 2 diabetes and fractures has been controversial. Canagliflozin has an FDA warning about the risk, but some studies have found no link.
Medscape Medical News

When Might Post-MI Beta-Blockers Be Safely Deprescribed?

Wed, 17 Jul 2019 10:39:12 +0000

If an older patient is ischemia-free on beta-blockers 3 years later, he or she doesn't seem to confer further protection over the next 5 years, suggests data from an admittedly older registry.
Medscape Medical News

CMS May Cover Acupuncture as Opioid Alternative for Back Pain

Wed, 17 Jul 2019 10:50:42 +0000

As an alternative to opioids, the Centers for Medicare & Medicaid Services is proposing coverage for acupuncture as a chronic low back pain treatment for patients in approved studies.
Medscape Medical News

The New Face of HIV and Treating the 'Hardly Reached'

Wed, 17 Jul 2019 08:26:50 +0000

As the world's biggest HIV conference approaches, researchers, drug companies, and public agencies are questioning whether the clinical trial designs they've always used will actually end the epidemic.
Medscape Medical News

Госдума поддержала возвращение курилок в аэропортах. Медики против

Wed, 17 Jul 2019 08:38:42 +0000

Депутаты приняли в первом чтении законопроект, допускающий курение в специально выделенных изолированных помещениях аэропортов. Места для курения будут оборудоваться в транзитных зонах аэропортов, а также в зонах, где находятся пассажиры, уже прошедшие предполетный досмотр. Противники инициативы считают, что она создает угрозу государственной политике по ограничению курения.

Stricter Gun Laws Tied to Fewer Childhood Gun Deaths

Tue, 16 Jul 2019 15:56:02 +0000

U.S. states with tighter restrictions on the purchase and use of guns and ammunition may have fewer children die from shootings, a new study suggests.
Reuters Health Information

Scales Tip Toward 'Fish Oil' PUFA Intake for HF Prevention

Tue, 16 Jul 2019 16:11:43 +0000

Heart failure risk fell with higher omega-3 fatty acid plasma levels in a major longitudinal cohort study. Some say it argues for a randomized HF trial of high-dose marine-oil supplement therapy.
Medscape Medical News

Kaiser Faces Strike Threat From 85,000 Service Workers

Tue, 16 Jul 2019 16:26:00 +0000

A coalition of unions will vote on a strike soon unless Kaiser Permanente returns to the bargaining table; at issue are outsourcing, robot attendants, and regional wage cuts.
Medscape Medical News

Less Snoring and Fatigue in Sleep Apnea Patients With Nasal Polyps

Tue, 16 Jul 2019 15:31:49 +0000

A study of men with chronic rhinosinusitis with nasal polyps (CRSwNP) and obstructive sleep apnea (OSA) shows that symptoms may be less pronounced than in those with classic OSA, according to Brazilian researchers.
Reuters Health Information

New Contraceptive Vaginal Ring Prevents Pregnancy for a Year, Gives Women More Control

Tue, 16 Jul 2019 15:48:59 +0000

A new contraceptive vaginal ring prevents pregnancy for a year and allows women to have complete control over conception, according to a report that details the results of two clinical trials testing the safety and efficacy of the device.
Reuters Health Information

Vaping May Aid Smoking Cessation but Also Boost Relapse Risk

Tue, 16 Jul 2019 15:37:41 +0000

Adults who smoke cigarettes may have an easier time cutting back or quitting altogether if they start vaping, but a new French study also suggests that vaping may make ex-smokers more likely to relapse.
Reuters Health Information

Striking New-Onset Seizure Risk in Dementia Patients

Tue, 16 Jul 2019 14:44:32 +0000

Patients with Alzheimer disease experience epileptic seizures up to 6.5 times more often than their cognitively normal peers, and often without the knowledge of their physician, new research suggests.
Medscape Medical News

AstraZeneca's Farxiga Fails to Get U.S. Approval for Type-1 Diabetes

Tue, 16 Jul 2019 14:10:57 +0000

British drugmaker AstraZeneca Plc said on Monday the U.S. Food and Drug Administration declined to approve its diabetes treatment, Farxiga, for use as a supplement to insulin in adults with a rare-type of the condition.
Reuters Health Information

U.S. Recorded 14 New Cases of Measles

Tue, 16 Jul 2019 13:03:07 +0000

The United States recorded 14 new measles cases between July 3 and July 11, federal health officials said on Monday, signaling a slowdown in the spread of the disease, which has infected 1,123 people this year in the worst U.S. outbreak since 1992.
Reuters Health Information

Oklahoma Lawyers at Trial's End Say Opioid 'Kingpin' J&J Fueled Epidemic

Tue, 16 Jul 2019 13:06:13 +0000

Lawyers for the state of Oklahoma on Monday compared Johnson & Johnson to a drug cartel leader as they sought to hold the drugmaker responsible for fueling the U.S. opioid epidemic in the first trial to result from lawsuits over the crisis.
Reuters Health Information

Ebola Spread to East Congo's Goma Massively Raises Risk: U.N.

Tue, 16 Jul 2019 13:09:25 +0000

Ebola's arrival in eastern Congo's main city of Goma severely raises the risk of the virus spreading if it takes root in this metropolis near the border with Rwanda, the World Health Organisation (WHO) warned on Monday.
Reuters Health Information

Britain Tells Canada and France to Pull Their Weight on Ebola

Tue, 16 Jul 2019 13:12:08 +0000

Britain's international development minister Rory Stewart called on France and Canada on Monday to offer more help in tackling the Ebola outbreak in Democratic Republic of Congo.
Reuters Health Information

Biden Healthcare Plan Draws Contrast With White House Rivals

Tue, 16 Jul 2019 13:45:48 +0000

Democratic presidential front-runner Joe Biden unveiled a $750 billion healthcare plan on Monday that he said would strengthen the Affordable Care Act, drawing a contrast with rivals who back a more sweeping "Medicare for All" government-run system.
Reuters Health Information

New Alzheimer's Drug Candidate a Head Scratcher

Tue, 16 Jul 2019 13:24:08 +0000

A placebo-controlled trial with a new Alzheimer's drug candidate has shown puzzling results in that despite appearing to lower tau levels it was not associated with any clinical benefit.
Medscape Medical News

Артериальное давление и уровень холестерина в молодости связаны со здоровьем сердца в старости

Tue, 16 Jul 2019 18:55:43 +0000

Согласно новому исследованию, повышенный уровень холестерина и артериального давления в возрасте до 40 лет выше может существенно повышать риск сердечно-сосудистых заболеваний (ССЗ) в более позднем возрасте.

Targeting Gene Mutation Alleviates Psychosis Symptoms

Tue, 16 Jul 2019 11:35:20 +0000

Schizophrenia is an 'umbrella diagnosis,' with many genetic causes. Targeting specific gene mutations may improve psychosis symptoms, potentially paving the way for future personalized medicine.
Medscape Medical News

Chronotherapy Improves Sleep in Mild Cognitive Impairment

Tue, 16 Jul 2019 11:43:31 +0000

A nonpharmacologic, multicomponent approach to reset the biological clock improves sleep quality in older adults with mild cognitive impairment.
Medscape Medical News

Animated Brain Teaches Children Healthy Lifelong Habits

Tue, 16 Jul 2019 10:29:35 +0000

An initiative featuring an animated brain called Robbie and various educational materials is a promising tool to promote brain health in children, results of a new study suggest.
Medscape Medical News

Sport-Inspired Risk Model Improves Cancer Risk Prediction

Tue, 16 Jul 2019 10:45:33 +0000

A risk assessment model that incorporates multiple factors to dynamically predict outcomes performs "markedly better" than the "crystal ball" exercises of the past, say researchers.
Medscape Medical News

ЮНИСЕФ: Спад охвата вакцинацией опасен для детей во всем мире

Tue, 16 Jul 2019 14:20:16 +0000

Опасное бездействие по вопросам вакцинации ставит детей всего мира под угрозу заболеваний, которые можно предотвратить, предупреждаетдетский фонд ООН (ЮНИСЕФ), обвиняя в этом конфликты, неравенство и халатность.

Exposing the 'Great Masquerader' in Maternal Mortality

Tue, 16 Jul 2019 06:39:36 +0000

Diligent screening will help clinicians identify women at risk for a leading cause of death in pregnancy and childbirth.
Medscape Medical News

U.S. Federal Judge Orders FDA to Implement 10-Month Deadline for E-Cig Applications

Mon, 15 Jul 2019 17:29:05 +0000

A U.S. federal judge on Friday ordered the Food and Drug Administration to impose a 10-month deadline for the submission of e-cigarette applications, turning the screws on companies like Juul Labs Inc whose products have come under intense scrutiny for their popularity among teenagers.
Reuters Health Information

Collaboration With US Med Schools Helps Rwanda Improve Women's Health Care

Mon, 15 Jul 2019 17:34:12 +0000

Rwandan women have better access to obstetrics and gynecology services thanks to an international partnership to train more doctors, a new study finds.
Reuters Health Information

Surgeries to Help Newborns Nurse May Have Become Too Common

Mon, 15 Jul 2019 17:53:19 +0000

Minor surgery to help newborns latch on and nurse may have become too common, a new study suggests.
Reuters Health Information

Parent-Only Education Program Helps Obese Preschoolers Lose Weight

Mon, 15 Jul 2019 17:07:46 +0000

A parent-only treatment program for preschoolers with obesity proved more effective than standard treatment involving the parent and child focusing on lifestyle changes in a randomized controlled trial.
Reuters Health Information

Experts Offering Free Pediatric Teleradiology Globally Welcome More Users

Mon, 15 Jul 2019 17:11:18 +0000

The World Federation of Pediatric Imaging (WFPI) provides expert pediatric teleradiology to referrers around the world, and encourage wider use of their services.
Reuters Health Information

Opioid Treatment May Reduce Contact With Law Enforcement

Mon, 15 Jul 2019 17:18:17 +0000

Opioid users who get treatment for their drug dependency are less likely to have police encounters or to be charged with crimes, an Australian study suggests.
Reuters Health Information

Docs Still in Dark on Anticoagulant Choice in Severe Kidney Disease

Mon, 15 Jul 2019 17:01:45 +0000

Although NOACs offer "similar or greater benefit" over warfarin-like drugs in early chronic kidney disease, lack of evidence in severe disease makes anticoagulant choice a judgment call, say experts.
Medscape Medical News

Cold Snare Polypectomy Safe Without Heparin Bridge?

Mon, 15 Jul 2019 17:08:47 +0000

A randomized controlled trial found the method was not inferior to the hot snare method plus heparin bridging and was linked with shorter procedures and hospital stays.
Medscape Medical News

Less Positive Emotional-Recognition Bias Linked to Depression in IBD

Mon, 15 Jul 2019 16:10:23 +0000

Depression in people with inflammatory bowel disease (IBD) is associated with less positive emotional-recognition bias, researchers from the U.K. report.
Reuters Health Information

Most Referrals of Women for Asymptomatic Microscopic Hematuria Are Inappropriate

Mon, 15 Jul 2019 16:41:18 +0000

More than half of referrals of women for asymptomatic microscopic hematuria are inconsistent with American Urological Association (AUA) guidelines, according to a retrospective study.
Reuters Health Information

Patient Characteristics No Help in Predicting Meniscal-Surgery Outcomes

Mon, 15 Jul 2019 16:50:56 +0000

Patient-reported outcomes one year after meniscal surgery can't be predicted with a model using as many as 18 preoperative factors, according to a new study.
Reuters Health Information

FDA Approves Gadobutrol (Gadavist) Contrast Agent for Cardiac MR

Mon, 15 Jul 2019 16:14:02 +0000

The new MR indication for Bayer's gadolinium-based agent, its fourth from the FDA, includes resting and stress myocardial perfusion in adults with known or suspected coronary artery disease.
FDA Approvals

Healthy Lifestyle Offsets Genetic Risk for Dementia

Mon, 15 Jul 2019 16:22:57 +0000

Adhering to a healthy lifestyle reduces the chances of developing dementia, even among those at genetic risk for dementia, new research suggests.
Medscape Medical News

Здоровые образ жизни и диета могут отсрочить наступление деменции

Mon, 15 Jul 2019 21:59:12 +0000

Здоровый образ жизни помогает компенсировать генетический риск деменции, согласно новому исследованию Университета Эксетера, опубликованному в Journal of American Medical Association и представленному в Лос-Анджелесе на Международной конференции Ассоциации Альцгеймера (14-18 июля 2019).

U.S. Democratic Hopeful Amy Klobuchar Proposes Drug Cost Plan Aimed at Seniors

Mon, 15 Jul 2019 15:43:12 +0000

Democratic presidential hopeful Amy Klobuchar unveiled a new plan on Friday to help lower the cost of pharmaceuticals purchased by seniors in the wake of the White House scrapping its own ambitious drug cost plan.
Reuters Health Information

Hearing, Vision Loss Raise Dementia Risk in Older Adults

Mon, 15 Jul 2019 14:10:18 +0000

Multisensory impairment may serve as a potential marker to help identify older adults at increased risk of developing dementia or Alzheimer disease.
Medscape Medical News

Anti-TNF Agents Linked to Increased Risk of IBD

Mon, 15 Jul 2019 14:51:46 +0000

A new study finds that patients with autoimmune disease treated with anti- tumor necrosis factor alpha have an increased risk of developing inflammatory bowel disease.
Medscape Medical News

Cut Just 300 Calories a Day to Benefit Heart, Even in the Healthy

Mon, 15 Jul 2019 14:52:40 +0000

Moderate calorie restriction can be started early in life to reduce the risk of cardiometabolic diseases; study in normal or slightly overweight adults under 50 described as "groundbreaking."
Medscape Medical News

Novel Agent May Offer More Rapid Migraine Pain Relief

Mon, 15 Jul 2019 13:06:17 +0000

An orally dissolving tablet formulation of an acute migraine drug in development may offer more rapid relief from migraine pain, new research suggests.
Medscape Medical News

'No Cure, No Pay' Pilot for Expensive Cancer Drugs

Mon, 15 Jul 2019 13:43:43 +0000

A new pilot project in the Netherlands experiments with a pay-for-performance model to help reduce drug costs.
Medscape Medical News

Mindfulness-Based Cognitive Therapy Cuts Migraine Disability

Mon, 15 Jul 2019 11:21:24 +0000

Some unexpected findings emerge from a study of a 'clinically feasible' approach to teaching mindfulness to people with migraine.
Medscape Medical News

Люди, родившиеся недоношенными, реже вступают в романтические отношения

Mon, 15 Jul 2019 17:40:26 +0000

Согласно новому исследованию, у недоношенных детей к моменту достижения ими совершеннолетия чаще могут возникать проблемы с партнерскими и сексуальными отношениями. Кроме того, у них чаще нет своих детей, по сравнению с родившимися доношенными. Результаты работы опубликованы в журнале JAMA Network Open.

Neighborhood and Race Tied to Odds Kids Will Receive CPR From Bystanders

Fri, 12 Jul 2019 18:14:38 +0000

African American children from poor neighborhoods who suffer cardiac arrest are among the least likely to receive cardiopulmonary resuscitation from a bystander, according to a new study that finds both neighborhood characteristics and race may play a role in who gets CPR.
Reuters Health Information

Worse Hearing in Middle Age Linked to Brain-Volume Loss

Fri, 12 Jul 2019 18:19:26 +0000

Hearing impairment (HI) in middle age is associated with loss of temporal-lobe volume, new research shows.
Reuters Health Information

Deep-Learning Tool Can Help Individualize Radiotherapy Doses Based on Imaging

Fri, 12 Jul 2019 18:23:04 +0000

A new deep-learning framework based on CT images can help predict treatment failure and allow individualization of radiotherapy doses, researchers report.
Reuters Health Information

Teenagers Who Report More Negative Consequences Benefit Most From Substance-Use Intervention

Mon, 15 Jul 2019 10:30:36 +0000

Teenagers who report more negative consequences from alcohol or marijuana use benefit most from a brief primary-care substance-use intervention, researchers report.
Reuters Health Information

Diverting Loop Ileostomy Increasingly Used to Manage Fulminant C Difficile Colitis

Sat, 13 Jul 2019 12:31:01 +0000

Diverting loop ileostomy (LI) is increasingly favored over total abdominal colectomy (TAC) for the surgical management of patients with fulminant Clostridium difficile colitis, according to a new study.
Reuters Health Information

US Medical Students Less Likely to Choose to Become Primary Care Doctors

Mon, 15 Jul 2019 10:35:05 +0000

The percentage of primary care positions filled by fourth-year medical students in 2019 was the lowest on record.
Kaiser Health News

Scar From Old MI Common When CAD Revealed at SCD Autopsy

Mon, 15 Jul 2019 06:16:22 +0000

Scars revealing old, likely silent MI were seen in 2 of 5 out-of-hospital sudden deaths of persons with coronary disease initially recognized at autopsy. What kind of screening is wisest?
Medscape Medical News

Можно ли управлять возрастом

Mon, 15 Jul 2019 11:23:22 +0000

Большинство современных биогеронтологов мира уверены, что продолжительность жизни человека может превышать 100 лет. Что такое биологический возраст, и как сделать так, чтобы он был меньше паспортного, рассказал Медновостям член международного общества междисциплинарной эстетической и антивозрастной медицины (WOSIAM) Андрей Тарасевич.

Ограничение калорий поможет сохранить здоровье сердца даже людям с нормальным весом

Sun, 14 Jul 2019 14:05:54 +0000

Сокращение ежедневного рациона взрослых с нормальным или немного превышающим норму весом всего на 300 калорий (6 печений Орео) снижает риск возникновения диабета и сердечно-сосудистых заболеваний. Результаты двухлетнего рандомизированного контролируемого исследования 218 человек от 21 до 50 лет описаны в The Lancet Diabetes & Endocrinology.

Ohio Hospital System Fires 23, CEO Resigns in Wake of OD Deaths

Fri, 12 Jul 2019 20:11:25 +0000

At least 25 families of patients have reportedly filed suits, and the former Mount Carmel physician charged with fentanyl overdose murders has pleaded not guilty in a related criminal case.
Medscape Medical News

Cardiovascular Biomarkers Improved After Metabolic Surgery for Diabetes

Fri, 12 Jul 2019 18:10:44 +0000

Cardiovascular biomarkers in people with type 2 diabetes improve to a greater extent after metabolic surgery than with medical therapy, according to results from the STAMPEDE trial.
Reuters Health Information

Lawmakers Seek Scientific Review of Plan to Tightly Regulate All Fentanyl Copycats

Fri, 12 Jul 2019 16:49:13 +0000

Lawmakers on the U.S. Senate Judiciary Committee have urged the Trump administration to conduct a scientific review of a Justice Department-backed bill to classify all illicit chemical knockoffs of the potent painkiller fentanyl in the same legal category as heroin.
Reuters Health Information

Many Teen Girls Pressured by Partners to Get Pregnant

Fri, 12 Jul 2019 16:45:03 +0000

Nearly one in eight sexually active teen girls are pressured by their partners to have unprotected sex and try to conceive when they don't want a baby, a U.S. study suggests.
Reuters Health Information

Support for Elective Induction of Labor at 39 Weeks in Some Low-Risk Women

Fri, 12 Jul 2019 16:35:45 +0000

There are benefits to electing to induce labor at 39 weeks gestation in low-risk women who have already given birth, according to two new studies.
Reuters Health Information

Pregnancy Outcomes Improved in Lupus

Fri, 12 Jul 2019 15:56:05 +0000

Pregnancy outcomes improved among women with lupus over the past 2 decades; one expert questioned results and stressed that these women are still at high risk for poor outcomes such as maternal death.
Medscape Medical News

Dosing Differences Opined for Costly Hemophilia Option

Fri, 12 Jul 2019 16:39:26 +0000

Achieving the goal of zero bleeds as patients pursue active lives will require divergent dosing, according to PROPEL trial investigators who evaluated whether more exposure to FVIII improves outcomes.
Medscape Medical News

PRAC Proposes New Measures to Avoid Methotrexate Dosing Errors

Fri, 12 Jul 2019 16:39:51 +0000

The measures aim to prevent misunderstandings of the dosing schedule that have led to patients taking the medicine daily instead of weekly for inflammatory diseases.
News Alerts

Air Quality Plummets as Wildfire Smoke Hits Alaska's Most Populous Cities

Fri, 12 Jul 2019 15:42:49 +0000

Smoke and soot from central Alaska wildfires have afflicted the subarctic city of Fairbanks with some of the world's worst air pollution in recent days, forcing many residents indoors and prompting one hospital to set up a "clean air shelter."
Reuters Health Information

In-Hospital Cardiac Arrest Burden Climbed in Last Decade

Fri, 12 Jul 2019 15:04:46 +0000

The prevalence of adult in-hospital cardiac arrest grew about 38% and in children it went up 18%, a new analysis finds. The question is, why?
Medscape Medical News

Another Alzheimer's Drug Bites the Dust

Fri, 12 Jul 2019 12:57:24 +0000

Amgen and Novartis will abandon work on umibecestat, an experimental BACE inhibitor for Alzheimer's disease, following evidence of worsening cognitive function in a clinical trial.
Medscape Medical News

Risk of Meningioma with Cyproterone: EMA Review Begins

Fri, 12 Jul 2019 12:57:32 +0000

Products containing the anti-androgens cyproterone and cyproterone acetate — widely used in European countries — have been associated with a risk of meningioma.
News Alerts

Idiopathic Intracranial Hypertension May Double CV Risk

Fri, 12 Jul 2019 12:05:13 +0000

Results of a new study suggest that idiopathic intracranial hypertension appears to be a systemic metabolic condition conferring a sizable increase in cardiovascular risk.
Medscape Medical News

'Double Whammy': Where do PCSK9 Inhibitors Fit for Diabetes/ACS?

Fri, 12 Jul 2019 12:15:59 +0000

Patients with diabetes as well as ACS and uncontrolled high cholesterol have a "double whammy" that makes them candidates for PCSK9 inhibitors to prevent CV events, says expert.
Medscape Medical News

Medicare Going in 'Right Direction' on Opioid Epidemic

Fri, 12 Jul 2019 12:17:41 +0000

A new report by the inspector general for HHS shows prescriptions to treat opioid addiction are way up in recent years, while prescriptions for the painkillers have fallen.
Kaiser Health News

Sex May Be Less Satisfying With Age, Too Few Women Seek Help

Fri, 12 Jul 2019 12:37:48 +0000

A new survey reveals patterns as to why older women do or don't have sex and shows that just 6% of postmenopausal women in the UK sought medical help for sexual dysfunction.
Medscape Medical News

Penalties Not Lowering Hospital-Acquired Infection Rates

Fri, 12 Jul 2019 10:40:26 +0000

A penalty program established to reduce infections and other complications in U.S. hospitals hasn't made these events less likely or reduced fatalities or repeat hospitalizations, a large study suggests.
Reuters Health Information

Poorly-Controlled Asthma Commonly Affects Pregnancy in U.S.

Fri, 12 Jul 2019 10:32:14 +0000

Asthma is often not well controlled during pregnancy, especially among publicly-insured women, according to a U.S. study.
Reuters Health Information

Addiction Center Owner Guilty in $57 Million Laundering Scheme

Fri, 12 Jul 2019 10:13:47 +0000

A Florida owner of a substance abuse treatment center has pled guilty to money laundering in connection with a hospital "pass-through" billing scheme, the Department of Justice has announced.
Medscape Medical News

Galcanezumab Cuts Frequency of Disabling Cluster Headaches

Fri, 12 Jul 2019 10:40:12 +0000

Galcanezumab is a welcome option for patients who have grown frustrated with currently available treatment options, one headache expert said.
Medscape Medical News

Внезапной остановке сердца часто предшествует "немой" инфаркт

Fri, 12 Jul 2019 16:40:06 +0000

Согласно новому финскому исследованию, опубликованному в JAMA Cardiology, многие люди, умирающие от внезапной остановки сердца, возможно, ранее перенесли инфаркт миокарда, даже не осознавая этого.

As Trump Outlines Plans, Major Gaps in Kidney Disease Care Unveiled

Fri, 12 Jul 2019 09:47:30 +0000

On the heels of the US government announcement that it plans to start to reshape how it deals with kidney disease, a new nationwide study reveals major gaps in care for this condition.
Medscape Medical News

'Big Three' Diseases Account for Most Diagnostic Error Harm

Fri, 12 Jul 2019 07:25:34 +0000

Targeting improvements in the diagnosis of vascular events, infections, and cancers could reduce a large number of errors resulting in severe harms, study shows.
Medscape Medical News

Дети матерей, привившихся от гриппа во время беременности, оказались совершенно здоровыми

Fri, 12 Jul 2019 13:16:23 +0000

Утверждения противников вакцинации о том, что вакцинация беременных женщин от гриппа повышает риск проблем со здоровьем у их будущих детей, были полностью опровергнуты в новом крупном исследовании, опубликованном в British Medical Journal.

PPI, H2RA Equally Good at Preventing Bleeding Recurrence in H. Pylori-Negative Ulcers

Fri, 12 Jul 2019 00:29:27 +0000

Lansoprazole and famotidine have comparable effects in preventing recurrent idiopathic gastroduodenal ulcer bleeding, a two-year randomized clinical trial shows.
Reuters Health Information

Ontario Cannabis Retailer Pulls CannTrust Products Over Unlicensed Facilities Use

Fri, 12 Jul 2019 00:18:26 +0000

The online retailer of cannabis run by Ontario, Canada's most populous province, said on Wednesday it had pulled several CannTrust products from its offerings, after the federal health regulator found the company sold cannabis produced in unlicensed facilities.
Reuters Health Information

White House Drops Bid to Redirect Drug Rebates to Seniors

Thu, 11 Jul 2019 19:00:44 +0000

HHS withdrew a proposal meant to redirect rebates on drug purchases from middlemen to patients on Medicare. The proposal, likely to raise premiums, had angered insurers but was supported by drugmakers.
Medscape Medical News

[Viewpoint] When ethics and politics collide in donor-funded global health research

Thu, 11 Jul 2019 23:00:08 +0000

In this Viewpoint, we share our experience of censorship in evaluation research for global health. Our experience shows a broader trend of donors and implementing partners who deliberately use ethical and methodological arguments to undermine essential research. In a context of chronic underfunding of universities and their growing dependence on donor-driven research grants, we propose several structural and cultural changes to prevent manipulation of research governance systems and to safeguard the independence of research.

[Health Policy] The G20 and development assistance for health: historical trends and crucial questions to inform a new era

Thu, 11 Jul 2019 23:00:08 +0000

One of the most important gatherings of the world's economic leaders, the G20 Summit and ministerial meetings, takes place in June, 2019. The Summit presents a valuable opportunity to reflect on the provision and receipt of development assistance for health (DAH) and the role the G20 can have in shaping the future of health financing. The participants at the G20 Summit (ie, the world's largest providers of DAH, emerging donors, and DAH recipients) and this Summit's particular focus on global health and the Sustainable Development Goals offers a unique forum to consider the changing DAH context and its pressing questions.

[Seminar] Adult spinal deformity

Thu, 11 Jul 2019 23:00:08 +0000

Adult spinal deformity affects the thoracic or thoracolumbar spine throughout the ageing process. Although adolescent spinal deformities taken into adulthood are not uncommon, the most usual causes of spinal deformity in adults are iatrogenic flatback and degenerative scoliosis. Given its prevalence in the expanding portion of the global population aged older than 65 years, the disorder is of growing interest in health care. Physical examination, with a focus on gait and posture, along with radiographical assessment are primarily used and integrated with risk stratification indices to establish optimal treatment planning.

[Clinical Picture] Multiple cases of umbilical hernias in children in rural Ghana

Thu, 11 Jul 2019 23:00:08 +0000

Five children—whose ages ranged from 3 to 11 years—attended our temporary medical camp complaining of variously sized protrusions in their abdomens pushing the umbilicus forward. The lesions had been present in all the patients since birth. All the children were spontaneous, normal vaginal deliveries, but none had been assessed by a doctor within the past 12 months. Interestingly, the remote village of Pataase, where we located our camp to provide basic medical care, in a rural area 25 km north of Cape Coast, the capital city of the Central Region of Ghana, was home to a total of 75 children—including the five (figure) with the umbilical protrusions.

[Articles] The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study

Thu, 11 Jul 2019 23:00:08 +0000

We found that the novel OPV2 candidates were safe and immunogenic in IPV-immunised adults, and our data support the further development of these vaccines to potentially be used for maintaining global eradication of neurovirulent type-2 polioviruses.

[Articles] Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Thu, 11 Jul 2019 23:00:07 +0000

Patients with ischaemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral haemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.

[Articles] Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial

Thu, 11 Jul 2019 23:00:07 +0000

Long-term use of dulaglutide was associated with reduced composite renal outcomes in people with type 2 diabetes.

[Articles] Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

Thu, 11 Jul 2019 23:00:07 +0000

Dulaglutide could be considered for the management of glycaemic control in middle-aged and older people with type 2 diabetes with either previous cardiovascular disease or cardiovascular risk factors.

[Department of Error] Department of Error

Thu, 11 Jul 2019 23:00:07 +0000

Bould H, Mars, B, Moran P, Biddle l, Gunnell D. Rising suicide rates among adolescents. Lancet 2019; 394: 116–17—In this Correspondence, data for the Joinpoint regression analysis from the Office for National Statistics were for England and Wales, specifically. This has now been specified in the title, main text, and figure legend. These corrections have been made to the online version as of July 11, 2019, and the printed version is correct.

[Department of Error] Department of Error

Thu, 11 Jul 2019 23:00:07 +0000

Imel EA, Glorieux FH, Whyte MP, et al. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. Lancet 2019; 393: 2416–27—In this Article, the error bars in figure 2B have been updated. In table 1, “Mean serum TmP/GFR concentration (mmol/L)” has been changed to “Mean TMP/GFR ratio (mmol/L)”. The appendix has also been corrected. These corrections have been made to the online version as of July 11, 2019.

[Correspondence] Using entertainment to improve lifestyles and health

Thu, 11 Jul 2019 23:00:07 +0000

Improvement of people's lifestyles is one of the most important initiatives of the UN's Sustainable Development Goals.1 However, 80% of cardiovascular deaths occur in low-income and middle-income countries (LMICs) because resources to implement healthy lifestyle measures are limited.2 Mass media campaigns are usually costly and might have an adverse effect on teenagers who rebel against the message.3 A possible cost-effective option is to use sports and entertainment media as platforms to influence people to lead healthier lifestyles.

[Correspondence] Global mental health – Authors' reply

Thu, 11 Jul 2019 23:00:07 +0000

We thank the correspondents for their comments and suggestions on the Lancet Commission on global mental health and sustainable development.1 They highlight several aspects regarding the implementation of the key recommendations made in the Commission.

[Correspondence] Global mental health

Thu, 11 Jul 2019 23:00:07 +0000

The Lancet Commission on global mental health and sustainable development1 was excellent and necessary. We were especially pleased to see recognition of the role of legislation in promoting the global mental health agenda. Historically, mental health has been the branch of medicine most closely aligned with the law, although mental health legislation often came to perpetuate violations of human rights rather than prevent them. The response of mental health professionals to this historical relationship, however, should not be to distance mental health from legislation, but to reimagine the partnership to protect people's liberty and improve services.

[Correspondence] Global mental health

Thu, 11 Jul 2019 23:00:07 +0000

As UK trainee psychiatrists sharing an interest in global mental health, we welcome the Lancet Commission on global mental health and sustainable development1 with enthusiasm. We concur that task sharing, as a central factor to scaling up global mental health care, requires engagement from multidisciplinary mental health specialists. We also agree that in addition to optimising clinical care at a distance, digital technologies can enhance the training and supervision of non-specialist health workers.

[Correspondence] Global mental health

Thu, 11 Jul 2019 23:00:07 +0000

To enhance the commitment of the Lancet Commission on global mental health and sustaintable development set out by Vikram Patel and colleagues1—to reframe the global mental health agenda within the broader conceptualisation of mental health, envisioned in the Sustainable Development Goals—we offer some suggestions for further reform.

[Correspondence] Rising suicide rates among adolescents in England and Wales

Thu, 11 Jul 2019 23:00:07 +0000

There are concerns that the incidence of affective disorders1 and self-harm2 is rising among adolescents. Whether this rise reflects an increase in population prevalence is unclear. The apparent increase could indicate a greater willingness to discuss such issues, and a better recognition of mental health difficulties by referring clinicians, rather than increases in morbidity.

[Correspondence] Schizophrenia: a neglected problem in Pakistan

Thu, 11 Jul 2019 23:00:07 +0000

Schizophrenia is a chronic brain disorder with symptoms of delusions, hallucinations, trouble with thinking or concentration, and a lack of motivation.1 The disorder affects about 21 million people worldwide,2 most of whom do not receive appropriate care. Many patients live in developing countries, including Pakistan.

[Correspondence] Poliopolis

Thu, 11 Jul 2019 23:00:07 +0000

Despite global withdrawal of monovalent oral live-attenuated type-2 polio vaccines (OPV2) in May, 2016, recent circulating vaccine-derived type-2 poliovirus (cVDPV2) outbreaks in Africa highlight the danger of polio re-emerging in high-risk populations with low levels of immunity because of poor vaccine coverage.1 The only appropriate countermeasure to control and minimise spread of such outbreaks is deployment of stockpiled monovalent OPV2 vaccine, but this approach could seed further cVDPV2 outbreaks.

[Perspectives] Escaping the scarcity loop

Thu, 11 Jul 2019 23:00:07 +0000

We belong to a group of medical educators who share a concern about pressures in our work that threaten our capacity for reflection and creativity. We meet regularly to discuss papers that might enhance our practice and recently came across one by Arthur Frank in which he outlines sociological influences on medical practice. Frank argues that sociologists have a duty to uncover the unexamined assumptions that underlie the discourses of today's society and to question these when needed. We were intrigued by Frank's use of the term “scarcity loop” to describe an assumption that he believes dominates health care.

[Perspectives] Words

Thu, 11 Jul 2019 23:00:07 +0000

You are in bed, held in a loop of sheets, one arm flung to the ward's blue light. A few of us stand near you, and our words—bradycardia…lunch…resus—fall on you, like hail. When I saw you here last, it was for results, your husband's voice beating with fury and—was it?—hope: “We never know what you'll tell us each time, what words you'll say.”

[World Report] Africa's first biobank start-up receives seed funding

Thu, 11 Jul 2019 23:00:07 +0000

The start-up aims to collect data from the African continent for better representation of genetic variability. Paul Adepoju reports.

[World Report] Migrants left in lurch without Safe Release programme

Thu, 11 Jul 2019 23:00:06 +0000

US Border Patrol has been releasing migrants in communities that have been struggling with providing health care. Bryant Furlow reports.

[Comment] Offline: Medicine and the Holocaust—it's time to teach

Thu, 11 Jul 2019 23:00:06 +0000

How can it be that in the 21st-century European nations are debating the rise of antisemitism? On the continent torn apart by a fascism that quickly became a genocide, it seems barely credible that antisemitism not only survives but also flourishes in increasingly populist and nationalist democracies. But survive and flourish it does. The UK's Labour Party, proud of its anti-racist history, has been reputationally wounded by repeated failures to expel those responsible for anti-Jewish activities.

[Comment] UK consultation on pulse oximetry screening for critical congenital heart defects in newborns

Thu, 11 Jul 2019 23:00:06 +0000

Universal screening allows potentially life-threatening diseases to be detected while presymptomatic. UK neonatal mortality is rising and in 2015 was ranked 19th out of 28 European countries.1 Congenital anomalies and infections are the main causes of UK term neonatal mortality, and most deaths from congenital anomalies are from cardiac defects.2 Critical congenital heart defects (CCHD) occur in two per 1000 livebirths and, if undetected, can result in collapse and death following closure of the ductus arteriosus.

[Comment] International failure in northwest Syria: humanitarian health catastrophe demands action

Thu, 11 Jul 2019 23:00:06 +0000

The 9-year conflict in Syria has resulted in one of the worst humanitarian crises of our generation, with more than 11·7 million people in need of humanitarian assistance in Syria, 11·3 million in need of health assistance, and 6·2 million internally displaced within Syria.1 In one of the worst onslaughts of the conflict to date, Syrian Government and Russian forces have intensified their ground shelling and airstrikes in northwest Syria since early April, 2019. This area contains an estimated 3 million people of whom 1·3 million are internally displaced people,2 who have already been displaced from other parts of Syria such as Aleppo and Eastern Ghouta by previous government offensives; the most severely affected area is in the southernmost part of the demilitarised zone of Idlib province.

[Comment] Polio endgame options: will we have the vaccines needed?

Thu, 11 Jul 2019 23:00:06 +0000

The Global Polio Eradication Initiative (GPEI), which launched in 1988 with a mandate to eradicate polio by 2000,1 has maintained its mission to stop and prevent the transmission of all three serotypes (1, 2, and 3) of wild poliovirus (WPV). Ultimately, ending all cases of poliomyelitis requires successful cessation of the use of all live-attenuated oral poliovirus vaccines (OPV) after certification of WPV eradication. Global transmission of serotype-2 WPV ended before 2000; in September, 2015, the world certified serotype-2 WPV eradication;2 and in late April and early May, 2016, the GPEI globally coordinated the cessation of all use of serotype -2-containing OPV (OPV2), except for in emergency uses to respond to serotype-2 outbreaks.

[Comment] Late thrombolysis for stroke works, but how do we do it?

Thu, 11 Jul 2019 23:00:06 +0000

Thrombolysis for ischaemic stroke is recommended up to 4·5 h from stroke onset.1 Beyond 4·5 h, endovascular clot retrieval2 is the standard of care in selected patients up to 24 h after the time they were last known to be well.3 However, immediate endovascular clot retrieval will not be available for all patients. In The Lancet, Bruce Campbell and colleagues4 report the findings of their meta-analysis of individual patient data from three intravenous thrombolysis trials (EXTEND,5 ECASS4-EXTEND,6 and EPITHET7) of late window (4·5–9 h) or wake-up stroke.

[Comment] Is it time to REWIND the cardiorenal clock in diabetes?

Thu, 11 Jul 2019 23:00:06 +0000

Following the regulatory requirements of 2008, randomised trials of glucose-lowering therapies have demonstrated safety, and in some cases superiority, with respect to cardiorenal outcomes. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have been shown to reduce cardiorenal outcomes across a broad spectrum of type 2 diabetes in the presence or absence of established vascular disease, and across a broad range of kidney function.1 These benefits appear independent of glycaemic control and are mediated through a range of mechanisms including effects on systemic and renal haemodynamics.

[Editorial] Research integrity: recognising the responsibilities of authors

Thu, 11 Jul 2019 23:00:06 +0000

Newly released documents reveal the extent of the research misconduct perpetrated over many years in the laboratory of a distinguished UK scientist—David Latchman, at the UCL Institute of Child Health, London. In response to three separate allegations of misconduct, relating to dozens of papers from Latchman's group published between 1990 and 2013, UCL initiated two formal investigations. And on July 1, after several Freedom of Information requests, UCL finally released the reports.

[Editorial] Regulators must work on indoor air pollution

Thu, 11 Jul 2019 23:00:06 +0000

On June 28, 2019, the National Institute for Health and Care Excellence (NICE) published draft guidance on indoor air quality at home, highlighting some perhaps unexpected sources of indoor air pollution. The Lancet has often spoken about indoor air pollution problems in countries where the burning of fuels inside the home is a common occurrence, but the NICE guidelines offer some thoughts on the sorts of pollution problems that can affect households worldwide.

[Editorial] Physician burnout: a global crisis

Thu, 11 Jul 2019 23:00:06 +0000

Hui Wang, a 32-year-old Chinese ophthalmologist, experienced sudden cardiac death on June 30, after working with fever for 6 days in Beijing. Hui was the father of a 1-year-old girl, and married to a doctor, who donated Hui's corneas to two patients after his death. The emotive circumstances of Hui's devotion to his work and his family's selfless donation have triggered an outpouring of grief and sympathy online, with many people expressing their condolences to his family, as well as raising concerns about physician burnout in China.

Any Microvascular Disease a Risk Factor for Limb Amputation

Thu, 11 Jul 2019 17:03:56 +0000

The risk climbs in people with microvascular disease even if it's in the eyes, kidneys, or nervous system, and with or without peripheral artery disease, say researchers.
Medscape Medical News

No Drop in Patient Outcomes With Reduced Resident Hours

Thu, 11 Jul 2019 17:20:31 +0000

With the new data showing similar patient outcomes, one expert stressed that the discussion now needs to shift from the total number of hours in the hospital to how those hours are spent.
Medscape Medical News

GSK's Two-Drug HIV Dovato Treatment Meets Main Goal in Study

Thu, 11 Jul 2019 16:12:34 +0000

GlaxoSmithKline Plc's two-drug HIV regimen Dovato was successful in suppressing the AIDS-causing virus in patients over 48 weeks at the same level of a previous three-drug treatment in a late-stage trial, the drugmaker said on Wednesday.
Reuters Health Information

Balance Between Benefits, Harms of Palliative Inotrope Therapy Unclear

Thu, 11 Jul 2019 16:30:33 +0000

The balance between benefits and harms of palliative intravenous inotrope therapy remains uncertain, according to a new review.
Reuters Health Information

Blood Biomarkers May Predict Concussion Recovery

Thu, 11 Jul 2019 16:34:20 +0000

Acute elevation of two serum inflammatory markers may predict symptom recovery time after sport-related concussion.
Medscape Medical News

President Urges Tanzania's Women to 'set Ovaries Free,' Have More Babies to Boost Economy

Thu, 11 Jul 2019 15:01:34 +0000

President John Magufuli urged Tanzania's women to "set your ovaries free" and bear more children as a way to help boost the economy into a regional powerhouse, a step critics said would instead worsen inequality and poverty.
Reuters Health Information

Most Perpetrators in 2018 Mass Attacks Made Threats - U.S. Secret Service

Thu, 11 Jul 2019 15:51:23 +0000

Most of those responsible for mass attacks in public areas in the United States in 2018 made prior threats or sent messages that sparked concern, the Secret Service said on Tuesday, in a study highlighting advance clues to such violence.
Reuters Health Information

ICD-11 Fails to Capture Psychiatric Patients' 'Lived Experience'

Thu, 11 Jul 2019 14:46:37 +0000

Many patients with mental illness believe the descriptions of these disorders in ICD-11 focus on external symptoms, rather than the internal or "lived" experience.
Medscape Medical News

Point-of-Care Test Cuts Antibiotic Use in COPD Exacerbations

Thu, 11 Jul 2019 13:08:11 +0000

Point-of-care testing for C-reactive protein reduced antibiotic use in patients seen for acute COPD exacerbations; editorialists say the results are compelling.
Medscape Medical News

Матрас не убьет вас, но может попытаться ранить ребенка

Thu, 11 Jul 2019 19:41:23 +0000

В ходе недавнего исследования ученые из Израильского технологического университета измерили уровень выбросов газообразных соединений, выделяемых некоторыми типами полиуретановых матрасов в условиях имитации сна. Они обнаружили достаточно высокий уровень некоторых ЛОВ, которые могут подвергать риску здоровье младенце

Употребление небольшого количества сладких напитков связано с несколькими видами рака

Thu, 11 Jul 2019 19:50:18 +0000

У людей, которые чаще пьют сладкие напитки, чаще развивается рак. Пока ученые не доказали, что эти напитки являются причиной рака, но эта связь установлена сравнительно давно. Результаты нового крупного французского исследования позволяют предположить, что ограничение их употребления может помочь сократить количество случаев заболевания раком.

California to Repay Loans of Docs Who Take Medicaid Patients

Thu, 11 Jul 2019 06:48:03 +0000

The new program will use tobacco taxes to repay nearly $60 million in loans for 247 physicians.
Medscape Medical News

«Дорожная карта» при диабете 2-го типа

Thu, 11 Jul 2019 10:34:37 +0000

Сахарный диабет 2-го типа – болезнь, которую можно держать под контролем. Но это требует от человека строгой дисциплины и постоянного внимания к своему здоровью. О том, как предотвратить осложнения при диабете, какой должна быть диета, и что лучше для больного – таблетки или инъекции инсулина, рассказала эндокринолог ГБУЗ «ГКБ № 17 ДЗМ» к.м.н. Яна Бурнашева.

Triple-Negative Breast Cancers More Likely to Hit Black and Younger Women

Wed, 10 Jul 2019 22:05:45 +0000

Black and younger women face elevated risks of developing breast cancers that are not only aggressive but also less responsive to treatment, a new study confirms.
Reuters Health Information

France Will End Healthcare Refunds for Homeopathic Drugs

Wed, 10 Jul 2019 22:24:15 +0000

France will end social security reimbursements for homeopathic drugs and the new policy - which has drawn the fire of alternative medicine advocates - will take full effect in 2021, the healthcare minister said on Tuesday.
Reuters Health Information

Nearly 600 Residents Scramble for Positions as PA Hospital Closes

Wed, 10 Jul 2019 20:23:54 +0000

Other programs are working to get additional GME spots approved for displaced Hahnemann University Hospital residents. "This is almost unheard of," one program director said.
Medscape Medical News

Online Database of Gene Activity in Mouse Models of Disease Can Reduce Animal Use in Experiments

Wed, 10 Jul 2019 19:08:35 +0000

A new comprehensive database of gene activity in mice across multiple disease models could significantly reduce animal use in experiments, researchers say.
Reuters Health Information

Opting Out of Procedures During Childbirth Tied to Discrimination

Wed, 10 Jul 2019 19:38:33 +0000

Women who decline certain procedures - such immediate cord clamping - during childbirth are more likely to report being treated poorly during their hospital stay, a U.S. study finds.
Reuters Health Information

Opioids Commonly Prescribed for Gout Attacks

Wed, 10 Jul 2019 18:15:35 +0000

Nearly three in 10 patients seeking care at the emergency department (ED) for acute gout will be discharged with a prescription for opioids, new research shows.
Reuters Health Information

Peroral Endoscopic Myotomy an Upfront Option for Achalasia

Wed, 10 Jul 2019 18:21:43 +0000

For the swallowing disorder achalasia, peroral endoscopic myotomy (POEM) provided better symptom control than pneumatic dilation but was associated with more reflux esophagitis in a multicenter randomized controlled trial.
Reuters Health Information

Trump Signs Order to Increase Kidney Donation, Home Dialysis

Wed, 10 Jul 2019 17:53:53 +0000

HHS plans to test voluntary and mandatory payment models intended to improve the care of people with kidney disease.
Medscape Medical News

'Pink Noise' Enhances Deep Sleep, May Improve Recall in Mild Cognitive Impairment

Wed, 10 Jul 2019 17:13:11 +0000

Sound stimulation with "pink noise" enhanced deep sleep and improved recall for some patients with mild cognitive impairment, in a small pilot study.
Reuters Health Information

Heparin Bridging Could Worsen Outcomes After Stroke

Wed, 10 Jul 2019 16:17:42 +0000

Bridging with low-molecular-weight heparin (LMWH) is associated with worse outcomes after stroke in patients with nonvalvular atrial fibrillation (AF), according to results from the RAF and RAF-NOACs studies.
Reuters Health Information

Novartis Launches Adamis Allergy Shots in U.S. Pharmacies Amid EpiPen Shortage

Wed, 10 Jul 2019 16:42:06 +0000

A unit of Novartis AG said on Tuesday it would make partner Adamis Pharmaceuticals Corp's emergency allergy shots immediately available in local pharmacies across the United States, amid a shortage of Mylan NV's rival product, EpiPen.
Reuters Health Information

Trump Administration Drug Officials Clash Over How to Combat Fentanyl Copycats

Wed, 10 Jul 2019 16:52:06 +0000

Trump administration officials are divided over part of a proposal to crack down on illicit versions of fentanyl, the deadly synthetic painkiller that U.S. President Donald Trump targeted in declaring a national opioid abuse emergency.
Reuters Health Information

Non-HDL Cholesterol a CV-Risk Crystal Ball for Young Adults

Wed, 10 Jul 2019 16:33:07 +0000

High levels at age 25–40 are likely to persist decades later, and indeed they predicted risk for cardiovascular disease. Are some young adults better candidates for statins than usually thought?
Medscape Medical News

Cutting MCI Risk: The More Mental Activities, the Better

Wed, 10 Jul 2019 16:35:15 +0000

Using the computer, crafting, playing games, and engaging in social activities, individually or in combination, may slow or prevent age-related memory loss, a large study suggests.
Medscape Medical News

Industry Money Fuels Gabapentin Prescribing

Wed, 10 Jul 2019 16:42:00 +0000

Physicians who receive payments from makers of brand-name gabapentinoids are almost twice as likely to prescribe the brand-name agents vs generic versions, new research suggests.
Medscape Medical News

Double-Barreled Biologic for Diabetic Retinopathy Emerging

Wed, 10 Jul 2019 15:41:14 +0000

Trial results for the first biologic to target both the VEGF and Ang-2 pathways designed for less frequent injections than current options will be presented at the upcoming retina conference.
Medscape Medical News

Steep Jump in Dementia Patient ED Visits Tied to Caregiver Depression

Wed, 10 Jul 2019 13:07:45 +0000

Researchers found that, over a 6-month period, caregiver depression was associated with a 73% increase in rates of emergency department visits by patients with dementia.
Medscape Medical News

More Americans Seek Alcohol-Free Social Spaces

Wed, 10 Jul 2019 12:10:43 +0000

A national trend of boozeless bars is cropping up nationwide to create social spaces without the hangovers, DUIs, and alcoholism culture. It's part of a new push for sober options.
Kaiser Health News

FDA Ends Months-Long FOIA Battle Over Medical Device Failures

Wed, 10 Jul 2019 11:10:59 +0000

KHN filed multiple Freedom of Information Act requests over months, and the FDA responded Wednesday saying the data about device malfunctions are now publicly available online.
Kaiser Health News

Shake-Up Needed in Thyroid Evaluation Before, During Pregnancy?

Wed, 10 Jul 2019 11:11:10 +0000

High, as well as low, maternal thyroid function is associated with poor brain development in kids. Early pregnancy is the most vulnerable period; results indicate it may be time for preconception thyroid testing.
Medscape Medical News

How Much Does Language Matter in Medicine?

Wed, 10 Jul 2019 10:32:24 +0000

Is it time to rethink the way physicians talk to -- and about -- patients?
Medscape Reader Polls

No Strong Evidence That Supplements Offer CV Protection

Wed, 10 Jul 2019 10:37:03 +0000

Most nutritional supplements and diet interventions had little to no effect on outcomes in a meta-analysis based only on randomized trials; when there was benefit, the evidence base was 'suboptimal.'
Medscape Medical News

Никому не известно, как распространена импотенция на самом деле

Wed, 10 Jul 2019 10:06:21 +0000

Сколько же мужчин на самом деле страдают от эректильной дисфункции (ЭД)? Ответ зависит от того, как и где вы задаете этот вопрос, потому что разброс данных достаточно высок - они варьируются от 3% до 76% мужчин.

Влияние БАДов и диет на здоровье сердца и сосудов оказалось ограниченным

Wed, 10 Jul 2019 10:50:37 +0000

Прием биологически активных добавок (БАД) и, возможно, даже следование диетам не защищает от сердечно-сосудистых заболеваний и преждевременной смерти, показал новый общий обзор метаанализов и рандомизированных контролируемых исследований, проведенный американскими учеными. Его результаты опубликованы в Annals of Internal Medicine.

Предиабет обычно так и не становится диабетом

Wed, 10 Jul 2019 08:45:30 +0000

Новое шведское исследование показало, что у пожилых людей со слегка повышенным уровнем сахара в крови («предиабетом»), чаще не развивается полноценный диабет. Его результаты опубликованы в Journal of Internal Medicine.

Legalizing Pot Tied to Less Teen Marijuana Use

Wed, 10 Jul 2019 01:03:37 +0000

Marijuana legalization laws don't appear to increase teen pot use and instead may have the opposite effect, a U.S. study suggests.
Reuters Health Information

Gut Bacteria Supplementation Improves Metabolic Parameters in Overweight Volunteers

Tue, 09 Jul 2019 19:53:58 +0000

Supplementation with the commensal gut bacteria Akkermansia muciniphila improved metabolic parameters in overweight and obese volunteers, in a proof-of-concept exploratory study.
Reuters Health Information

Seizures, Coma More Common With Synthetic Cannabinoids in Adolescents

Tue, 09 Jul 2019 20:00:02 +0000

Serious neuropsychiatric adverse events in adolescents are far more common with acute synthetic cannabinoid toxicity than with traditional cannabis toxicity, according to a registry study.
Reuters Health Information

12-Month Supply of Birth Control Pills Cuts Unintended Pregnancies, Cost

Tue, 09 Jul 2019 20:34:45 +0000

When women are given a 12-month supply of oral contraceptives, they are less likely to have an unintended pregnancy than if they need to get refills every three months, a new study shows.
Reuters Health Information

U.S. Judge Halts Rule Requiring Drug Prices in TV Ads

Tue, 09 Jul 2019 20:10:47 +0000

A federal judge on Monday blocked the Trump administration from implementing a new rule that would force pharmaceutical companies to include the wholesale prices of their drugs in television advertising.
Reuters Health Information

U.S. Health Officials Record 14 New Cases of Measles as Outbreak Slows

Tue, 09 Jul 2019 19:48:58 +0000

The United States recorded 14 new measles cases between June 27 and July 3, federal health officials said on Monday, signaling a slowdown in the spread of the disease that has infected 1,109 people this year in the worst U.S. outbreak since 1992.
Reuters Health Information

Appeals Court Judges Appear Skeptical About ACA's Future

Tue, 09 Jul 2019 18:35:20 +0000

If its line of questioning serves as a barometer, a three-judge panel of the US Fifth Circuit Court of Appeals seemed to lean toward the case brought by those arguing against the ACA.
Medscape Medical News

U.N.'s Bachelet "Appalled" at U.S. Treatment of Migrants and Refugees

Tue, 09 Jul 2019 16:56:59 +0000

U.N. human rights chief Michelle Bachelet is "appalled" at the conditions in which the United States is keeping detained migrants and refugees, including children, her office said in a statement on Monday.
Reuters Health Information

Calculator Aims to Take Full Advantage of hs-Tn in Suspected MI

Tue, 09 Jul 2019 17:40:36 +0000

Focusing on rapid changes in troponin levels at serial testing, with or without a new risk calculator, "is the way to capitalize" on the advantages of the high-sensitivity assays, says an observer.
Medscape Medical News

AFM 'Season' Starts With 11 Cases, CDC Urges Docs to Be Vigilant

Tue, 09 Jul 2019 16:00:07 +0000

Early recognition, specimen collection, and reporting are critical to better understand acute flaccid myelitis (AFM) and provide patients with appropriate care and rehabilitation, the CDC says.
News Alerts

No Drop in Pulmonary Embolism With Early IVC Filters

Tue, 09 Jul 2019 12:08:37 +0000

The composite of death and pulmonary embolism at 90 days was approximately the same in severe trauma patients both with and without implanted inferior vena cava filters, a study found.
Medscape Medical News

'First Evidence' Links Gut Bacteria, Fibromyalgia

Tue, 09 Jul 2019 12:33:13 +0000

Patients with fibromyalgia appear to have microbiome alterations, including deletions and an abundance of specific gut bacteria that differ from healthy controls.
Medscape Medical News

Survival of In-Hospital Arrests Shine Under BSN Nurse Care

Tue, 09 Jul 2019 12:46:06 +0000

More nurses with nursing bachelor's degrees and a lower patient-to-nurse ratio were formulas for better survival to discharge with intact neurologic function in a new analysis.
Medscape Medical News

CRC Patients Report on How They Are Treated: Survey Results

Tue, 09 Jul 2019 11:10:38 +0000

European oncologists should team up with patients and learn from the US in strengthening advocacy efforts to improve accessibility to drugs and address unmet needs, a Europe-wide survey suggests.
Medscape Medical News

Industry Payments to Gastroenterologists Tied to Biologic Rx

Tue, 09 Jul 2019 11:24:59 +0000

Gastroenterologists who received gifts or funds from drug manufacturers were more likely to prescribe biologics for inflammatory bowel disease, new data show.
Medscape Medical News

Antidepressant Use Cuts Deaths by a Third in Those With Diabetes

Tue, 09 Jul 2019 10:13:57 +0000

For patients with comorbid new-onset diabetes and subsequent major depression, use of drugs from most antidepressants classes resulted in a 35% lower mortality rate over 10 years.
Medscape Medical News

New Hope for Resistant Obsessive Compulsive Disorder

Tue, 09 Jul 2019 10:25:13 +0000

High-frequency deep transcranial magnetic stimulation is safe and effective in reducing symptoms of treatment-resistant obsessive-compulsive disorder, new research suggests.
Medscape Medical News

Силовые тренировки сжигают жир вокруг сердца

Tue, 09 Jul 2019 15:40:59 +0000

По данным нового датского исследования, опубликованного в JAMA Cardiology, силовые тренировки (с отягощением) способствуют сжиганию жира, который откладывается вокруг сердца и связан с сердечно-сосудистыми заболеваниями.

Seniors May Need New Shoes to Avoid Pain, Prevent Falls

Tue, 09 Jul 2019 09:42:52 +0000

Because our feet change shape as we age, shoes that fit when we were young may become uncomfortable and unsafe in our senior years, a research review suggests.
Reuters Health Information

Antibiotics for Pneumonia: Short Course is More Effective

Tue, 09 Jul 2019 09:19:29 +0000

Most patients hospitalized with community-acquired pneumonia received longer duration antibiotic therapy than needed, increasing the risk of post-discharge adverse events, a large study found.
Medscape Medical News

Экономическое бремя болезней, связанных с ВПЧ, превысило в России 60 миллиардов рублей

Tue, 09 Jul 2019 09:09:10 +0000

Обнародованы результаты масштабного исследования экономического и социально-демографического бремени заболеваний, ассоциированных с вирусом папилломы человека и экономической эффективности вакцинации против вируса папилломы человека в России. Как показало исследование, вакцинация 12-летних девочек против ВПЧ в нашей стране является экономически эффективной мерой профилактики.

Custom Menopause Hormones Have Unpredictable Ingredient Mix

Mon, 08 Jul 2019 21:55:29 +0000

Women who fill prescriptions for compounded, custom-blended hormone therapy may get capsules or creams that don't contain the correct amount of medicine, a recent study suggests.
Reuters Health Information

Core-Temperature Increase May Not Trigger Hot Flashes

Mon, 08 Jul 2019 21:30:44 +0000

Small rises in core temperature are unlikely to trigger hot flashes, according to new findings.
Reuters Health Information

Early-Onset Sepsis Risk-Calculator Curbs Antibiotic Overuse in Newborns

Mon, 08 Jul 2019 21:48:53 +0000

Integrating an early-onset sepsis (EOS) risk calculator into the electronic health record (EHR) reduced antibiotic orders in a newborn nursery, with no increase in adverse events, researchers say.
Reuters Health Information

Most Older Adults With Prediabetes Don't Develop Diabetes

Mon, 08 Jul 2019 21:47:33 +0000

Older adults with slightly elevated blood sugar (prediabetes) usually don't develop full-blown diabetes, a Swedish study suggests.
Reuters Health Information

3D Printed Models May Best CT/MRI for Renal Tumor Localization

Mon, 08 Jul 2019 21:42:19 +0000

Experienced surgeons had trouble identifying the locations of kidney tumors on 3-dimensional models based only on information from typical 2-dimensional preoperative imaging, a new study found. The authors say 3D models could improve surgical planning.
Reuters Health Information

Indonesia's Top Court Jails Woman Who Reported Sexual Harassment

Mon, 08 Jul 2019 21:38:23 +0000

Indonesia's Supreme Court has jailed a woman who tried to report her employer for alleged sexual harassment, in a ruling that rights groups said on Friday risked turning victims of sexual abuse into criminals.
Reuters Health Information

Specialists More Sought After Than Primary Care Doctors: Report

Mon, 08 Jul 2019 18:17:31 +0000

A new report for 2018/2019 shows that 78% of searches were for specialists, up from 67% 4 years ago. Cardiologists lead in average starting salaries, with family medicine physicians at the lower end.
Medscape Medical News

Low LDL Means Higher Hemorrhagic Stroke Risk

Mon, 08 Jul 2019 18:39:10 +0000

Low LDL cholesterol levels may raise the risk for intracerebral hemorrhage, say researchers who assessed more than 96,000 study participants.
Medscape Medical News

EHR Happy Hour Smooths Out Kinks for Docs

Mon, 08 Jul 2019 17:00:22 +0000

Monthly small-group meetings have produced low-effort, high-yield solutions to nagging EHR mysteries and provided unexpected social benefits.
Medscape Medical News

Fresh Approach May Detect Consciousness in Unresponsive Patients

Mon, 08 Jul 2019 17:45:14 +0000

A new study adds evidence to the evolving and controversial detection of consciousness in unresponsive patients following severe brain injury.
Medscape Medical News

Endurance, Resistance Exercise Shrinks Cardiac Fat in the Obese

Mon, 08 Jul 2019 16:26:50 +0000

Both pericardial and epicardial fat mass fell in obese adults on a 12-week endurance- or resistance-training program, but only one exercise type worked on both kinds of cardiac adipose tissue.
Medscape Medical News

Giving Up Alcohol Boosts Mental Health in Women

Mon, 08 Jul 2019 15:18:03 +0000

In two large cohorts, mental health was best among men and women who were lifetime abstainers, but women who quit neared that level of good mental health within a few years, according to a new study.
Medscape Medical News

Stevie Wonder to Have Kidney Transplant in the Fall

Mon, 08 Jul 2019 10:58:43 +0000

Stevie Wonder has announced he is to undergo a kidney transplant from a living donor. Expert says Wonder going public is "brave" and will help raise awareness of an under-represented condition.
Medscape Medical News

AHS 2019: More Guidance on New Migraine Agents and Triggers

Mon, 08 Jul 2019 10:02:00 +0000

Practical experience using CGRP antibodies to treat or prevent migraine, as well as novel findings on possible environmental triggers, are among expected highlights of the upcoming AHS 2019 Annual Meeting.
Medscape Medical News

Active Sex Life Linked to Reduced Parkinson's Symptoms in Men

Mon, 08 Jul 2019 10:33:38 +0000

Men with Parkinson's disease who are sexually active have fewer motor and non-motor symptoms and better quality of life, new research shows.
Medscape Medical News

Недостаток сна и отсутствие режима сна чреваты серьезными проблемами со здоровьем

Mon, 08 Jul 2019 15:23:08 +0000

Большая разница в графике сна ото дня ко дню увеличивает риск одновременного возникновения метаболических нарушений, в том числе повышения уровня сахара в крови, артериального давления и избытка жира. Об этом свидетельствую данные исследования, опубликованного в Diabetes Care.

Гипертония при беременности и инфаркт или инсульт после 40 связаны

Mon, 08 Jul 2019 15:45:27 +0000

Как установило исследование норвежских авторов, повышенное АД в период беременности увеличивает риск инфарктов в зрелом и пожилом возрасте. У таких женщин инфаркт или инсульт случался на 57% чаще, чем у тех, кто не страдал от высокого артериального давления во время беременности.

«Оборудование для диагностики РМЖ у нас такое же, как и за рубежом. Вопрос в организации»

Mon, 08 Jul 2019 10:20:47 +0000

Своевременное выявление рака молочной железы – залог того, что пациентка сможет полностью вылечиться и вернуться к полноценной жизни. О технологиях обнаружения рака на ранней стадии рассказала зав. научно-исследовательским отделом профилактики, комплексной диагностики и лечения заболеваний молочной железы Российского научного центра рентгенорадиологии д.м.н. Елена Меских.

U.S. Judge Blocks Ohio 'Heartbeat' Law to End Most Abortions

Fri, 05 Jul 2019 17:13:18 +0000

A federal judge on Wednesday blocked Ohio from enforcing a new law that critics said would effectively ban most abortions in the state, starting as early as six weeks into pregnancy.
Reuters Health Information

Epigenetic Events Can Promote Liver Regeneration in Mice

Fri, 05 Jul 2019 17:12:55 +0000

Epigenetic events can contribute to liver regeneration, according to studies in mice.
Reuters Health Information

Drug-Resistance Mutations May Curb Efficacy of Dolutegravir-Based Regimens in Zimbabwe Teens With HIV

Fri, 05 Jul 2019 17:04:21 +0000

Implementation of dolutegravir (DTG)-containing antiretroviral therapy (ART) regimens for adolescents in Zimbabwe may require additional drugs and surveillance for drug resistance mutations (DRMs), researchers say.
Reuters Health Information

FDA OKs Immunoglobulin Xembify for Primary Immunodeficiencies

Fri, 05 Jul 2019 16:56:45 +0000

Xembify is a 20% immune globulin solution for subcutaneous injection indicated to treat primary immunodeficiencies in patients aged 2 years and older.
FDA Approvals

Electronic Consults With Allergists Save Time for Doctors and Patients

Fri, 05 Jul 2019 15:52:08 +0000

When allergy specialists advise other doctors via "e-consults," everyone - patients included - saves time, a new study suggests.
Reuters Health Information

Standardized Survey Promotes Disclosure of Unsafe Sleep Practices

Fri, 05 Jul 2019 15:51:42 +0000

Asking more specific questions can increase new mothers' disclosure of sleep practices deemed unsafe, according to new research.
Reuters Health Information

Gender Bias in Medicine Still Common

Fri, 05 Jul 2019 15:40:22 +0000

Prominent figures should stop questioning whether bias exists and do more to address its effects, study author says.
Medscape Medical News

Novel Therapies for Stroke Under the Microscope

Fri, 05 Jul 2019 15:42:30 +0000

Two new therapies show potential for ischemic stroke, but they have only been tested in mice and ex vivo thrombi to date.
Medscape Medical News

Some With Type 1 Diabetes Misdiagnosed; Call for Genetic Screening

Fri, 05 Jul 2019 11:17:47 +0000

An in-depth study of Joslin Medalists suggests some thought to have had type 1 diabetes for 50 years may have been misdiagnosed and may be able to come off insulin and take oral glucose lowering drugs instead.
Medscape Medical News

CBD as a Superbug Antibiotic?

Fri, 05 Jul 2019 12:00:39 +0000

Cannabidiol, or CBD, already being researched and used for anxiety, insomnia, epilepsy and pain, may be the next superbug fighter for resistant infections, a new study suggests.
WebMD Health News

New Guideline for Trigeminal Neuralgia Released

Fri, 05 Jul 2019 10:56:19 +0000

A new European Academy of Neurology guideline updates recommendations for diagnosing and treating a condition that can cause excruciating pain and is difficult to diagnose and treat.
Medscape Medical News

Ketamine Promising in Cocaine Addiction

Fri, 05 Jul 2019 09:29:14 +0000

Cocaine addiction is notoriously difficult to treat with drugs or psychotherapy. A single ketamine infusion combined with mindfulness training may work synergistically to promote abstinence and cut cravings.
Medscape Medical News

Nerve Transfer Surgery a 'Game Changer' for Spinal Cord Injury

Fri, 05 Jul 2019 08:11:04 +0000

A procedure in which working nerves are rerouted to paralyzed muscles has shown improvements in hand and arm function, giving patients with spinal cord injury "a whole new realm of independence."
Medscape Medical News

Этот вид лечения рака простаты увеличивает риск деменции на 20%

Fri, 05 Jul 2019 10:00:39 +0000

По данным нового американского исследования, у пациентов с раком простаты, проходивших антигормональную терапию, повышался риск развития деменции и болезни Альцгеймера.

«Низкая медицинская грамотность – это мировая проблема»

Fri, 05 Jul 2019 10:38:33 +0000

Такого обилия медицинской информации, как сегодня, в истории человечества не было никогда. Погружаясь в пучины интернета, люди не только ищут там советы по здоровому образу жизни, но и сами ставят себе диагнозы и назначают лечение. Но несмотря на доступность специальных знаний, оставаться санитарно-грамотным человеком с каждым годом становится все труднее, считают специалисты.

«Жаворонки» несколько реже болеют раком молочной железы

Fri, 05 Jul 2019 08:20:06 +0000

У «жаворонков» ниже риск развития рака молочной железы, чем у «сов», обнаружило международное исследование, проведенное под руководством профессора Кэролайн Релтон (Caroline Relton) и опубликованное в British Medical Journal. Кроме того, согласно полученным результатам, сон дольше рекомендуемых 7-8 часов в сутки связан с повышенным риском.

[Review] The public health control of scabies: priorities for research and action

Thu, 04 Jul 2019 23:00:08 +0000

Scabies is a parasitic disease of the skin that disproportionately affects disadvantaged populations. The disease causes considerable morbidity and leads to severe bacterial infection and immune-mediated disease. Scientific advances from the past 5 years suggest that scabies is amenable to population-level control, particularly through mass drug administration. In recognition of these issues, WHO added scabies to the list of neglected tropical diseases in 2017. To develop a global control programme, key operational research questions must now be addressed.

[Seminar] Nasopharyngeal carcinoma

Thu, 04 Jul 2019 23:00:08 +0000

Nasopharyngeal carcinoma is characterised by distinct geographical distribution and is particularly prevalent in east and southeast Asia. Epidemiological trends in the past decade have shown that its incidence has declined gradually but progressively, and mortality has been reduced substantially. These findings probably reflect lifestyle and environmental changes, enhanced understanding of the pathogenesis and risk factors, population screening, advancements in imaging techniques, and individualised comprehensive chemoradiotherapy strategies.

[Clinical Picture] Gallstone causing gastric outlet obstruction 50 years after cholecystectomy

Thu, 04 Jul 2019 23:00:07 +0000

A 90-year-old woman was transferred to our hospital with a 7-day history of pain in the right upper quadrant of her abdomen, decreased appetite, and post-prandial vomiting. On examination, she was afebrile, mildly tachycardic, at 95 beats per min, and in atrial fibrillation. Her blood pressure was 125/75 mm Hg. Clinically, she looked dehydrated and had a scar over the right hypochondrium, which was slightly tender, with a palpable mass, but she had no peritonism. In her medical history, she had a cholecystectomy approximately 50 years ago.

[Articles] Robot assisted training for the upper limb after stroke (RATULS): a multicentre randomised controlled trial

Thu, 04 Jul 2019 23:00:07 +0000

Robot-assisted training and EULT did not improve upper limb function after stroke compared with usual care for patients with moderate or severe upper limb functional limitation. These results do not support the use of robot-assisted training as provided in this trial in routine clinical practice.

[Articles] Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial

Thu, 04 Jul 2019 23:00:07 +0000

Oral semaglutide was non-inferior to subcutaneous liraglutide and superior to placebo in decreasing HbA1c, and superior in decreasing bodyweight compared with both liraglutide and placebo at week 26. Safety and tolerability of oral semaglutide were similar to subcutaneous liraglutide. Use of oral semaglutide could potentially lead to earlier initiation of GLP-1 receptor agonist therapy in the diabetes treatment continuum of care.

[Articles] Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study

Thu, 04 Jul 2019 23:00:07 +0000

D-VTd before and after autologous stem-cell transplantation improved depth of response and progression-free survival with acceptable safety. CASSIOPEIA is the first study showing the clinical benefit of daratumumab plus standard of care in transplant-eligible patients with newly diagnosed multiple myeloma.

[Department of Error] Department of Error

Thu, 04 Jul 2019 23:00:07 +0000

Pratley R, Amod A, Hoff ST, et al. Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial. Lancet 2019; 394: 39–50—In this Article, in panel C of figure 2, the p value for the proportion of patients achieving the HbA1c target of less than 7·0% for oral semaglutide versus liraglutide by use of the trial product estimand should have been “p=0·0620”; in table 2, the p value for the estimated odds ratio for HbA1c ≤·5% at 26 weeks for the liraglutide group by use of the trial product estimand should have been “p=0·1503”, the 95% CI range for the estimated odds ratio for bodyweight loss ≥10% at 26 weeks in the liraglutide group by use of the trial product estimand should have been “(1·52 to 5·05)”, and the estimated odds ratio for bodyweight loss ≥10% at 52 weeks in the placebo group by use of the trial product estimand should have been “8·39 (2·79 to 25·26); p=0·0002”.

[Department of Error] Department of Error

Thu, 04 Jul 2019 23:00:07 +0000

Gazzard G, Konstantakopoulou E, Garway-Heath D, et al. Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet 2019; 393: 1505–16—In this Article, the data for the laser trabeculoplasty group and the eye drops group were incorrectly switched in several places. The third paragraph of the Results section should have begun: “At 36 months, the selective laser trabeculoplasty group had an average EQ-5D score of 0·90 (SD 0·16), compared with 0·89 (SD 0·18) in the eye drops group…”.

[Department of Error] Department of Error

Thu, 04 Jul 2019 23:00:07 +0000

Green A. HIV epidemic in children in Pakistan raises concern. Lancet 2019; 393: 2288—In this World Report, the words “so-called” were mistakenly added to the sentence: “The so-called epidemic could be found to have reached adults as well”. This correction has been made to the online version as of June 7, 2019.

[Correspondence] Plan S: the final cut—response from cOAlition S

Thu, 04 Jul 2019 23:00:07 +0000

On behalf of the cOAlition S Executive Steering Group, I commend the Editors of The Lancet for their positive support for Plan S and the ambition to make full and immediate open access a reality. Finding ways in which researchers can seek to publish in their preferred journals, while ensuring that the outputs of funded research can be accessed and used by all, is a key part of our strategy.

[Correspondence] Another blow to credibility in published data sources – Author's reply

Thu, 04 Jul 2019 23:00:07 +0000

Michael Rigby and colleagues have pointed out the changes in the Global Burden of Disease (GBD) estimates over the previous iterations of GBD 2016 and GBD 2017. They argue that estimates should not change, and we beg to differ. Sound, evidence-based decision making should be based on the best available evidence estimated using up-to-date methods and the most recent empirical data. More recently available data and improved methods surely will change our estimates, and such change should be encouraged; one should certainly not prefer a false sense of assurance based on unchanged estimates.

[Correspondence] Another blow to credibility in published data sources

Thu, 04 Jul 2019 23:00:07 +0000

In the period since submission of our previous Correspondence,1 a new event has occurred that further questions the utility of some published data—the Institute for Health Metrics and Evaluation (IHME) has updated its Global Burden of Disease (GBD) data, which includes revision of historic facts. Our example based on that source quoted mortality data for children aged 10–14 years in 2015; these data have now been changed, and moreover, the previous data are no longer displayed. The new data were published too late to be used in the Models of Child Health Appraised project, funded by the EU Horizon 2020 programme, which has now concluded.

[Correspondence] How should the health-care community respond to human rights violations?

Thu, 04 Jul 2019 23:00:07 +0000

The Editors1 drew on Human Rights Watch's World Report 20192 to warn about a range of human rights violations and their effect on health and also highlight a new-found momentum for resistance to these violations. I thank The Lancet for highlighting these issues and for the call to action, namely that resistance to such abuses should continue throughout 2019. Although many will agree that the health-care community have a part to play in fighting human rights violations, how we can be most effective in putting up such resistance and in pursuing social and political change are far more difficult questions.

[Correspondence] Is high use of caesarean section sometimes justified?

Thu, 04 Jul 2019 23:00:07 +0000

We read with great interest the recent Lancet Series on optimising caesarean section (CS) use and, being situated at a tertiary referral centre in Greece—a country with a high prevalence of CS1 and with shrinking health-care funding due to a prolonged period of austerity—we would like to add our perspective on the topic.

[Correspondence] Global epidemiology of use of and disparities in caesarean sections – Authors’ reply

Thu, 04 Jul 2019 23:00:07 +0000

We are grateful to Suzanne Delport and Jonathan Wells and colleagues for their comments on our analysis of the global epidemiology of caesarean section (CS).1 We agree with Delport that South Africa has an extremely high prevalence of CS deliveries in private facilities. Data from the South Africa Demographic and Health Survey 2016,2 which only became available after the publication of our Lancet Series paper, suggest a CS prevalence of 61·3 per 100 livebirths in private health facilities, compared with 21·7 per 100 livebirths in public facilities.

[Correspondence] Global epidemiology of use of and disparities in caesarean sections

Thu, 04 Jul 2019 23:00:07 +0000

Ties Boerma and colleagues1 give an excellent review of the global increase in caesarean section (CS) use, and identify two key factors driving increases in CS use that relate poorly to medical need: a shift to more births occurring in health facilities, and increasing provision of CS in such facilities. In a related paper in the same Series, Ana Betrán and colleagues2 identify several additional predictors of unnecessary CS use, encompassing behavioural, psychosocial, health system, and financial factors.

[Correspondence] Global epidemiology of use of and disparities in caesarean sections

Thu, 04 Jul 2019 23:00:07 +0000

In their Series on optimising caesarean section (CS) use, Ties Boerma and colleagues1 report on 98·4% of the world's births in 2015 from 169 countries. They found that CS use in some low-income and middle-income countries was more frequent in private health-care facilities than in public health-care facilities.1 In this respect, the Series paper singles out Brazil as a country where CS is the predominant delivery mode in private facilities.1 Gilberto Magalhães Occhi and colleagues2 contrasted the rates of CS in Brazil in private facilities (83% of all deliveries) versus public facilities (41%; with public facilities being those hospitals registered in the Unified Health System) for the year 2016.

[Correspondence] Five national academies call for global compact on air pollution and health

Thu, 04 Jul 2019 23:00:07 +0000

Air pollution causes 7 million premature deaths each year,1 and deaths due to ambient air pollution are on track to double by 2050.2 Yet despite its enormous health and economic impacts, air pollution is accepted by many governments as an unavoidable consequence of economic growth. Prevention of air pollution is underfunded in official development assistance and, as yet, no major foundation has made air pollution its priority.

[Perspectives] Physician narratives of illness

Thu, 04 Jul 2019 23:00:07 +0000

In psychiatrist Linda Gask's memoir The Other Side of Silence, she describes an exhaustive experience of depression during medical school. “There came a point when I couldn't go on. My head was splitting open and I struggled to hold the pieces of my brain together”, Gask writes. Her candid memoir is part of a changing trajectory of physician narratives of illness that have moved from often anonymised accounts in the early 20th century to deeply personal, owned contemporary works. We've examined a selection of physician narratives of illness from the UK and USA and discovered how illness can conflict with doctors’ professional identities and how difficult it can be for health professionals to be open about illness, especially mental health problems.

[Perspectives] Takeshi Kasai: the health security thinker from Japan

Thu, 04 Jul 2019 23:00:06 +0000

“We cannot stand still, because our region is extremely dynamic: it is rapidly changing—economically, socially, and environmentally. This means that to stay relevant and valuable, we must also stay ahead of the curve”, says Takeshi Kasai, who has been Regional Director of the WHO Regional Office for the Western Pacific (WPRO) since February, 2019. This is essential, he says, “to be more effective” in meeting the needs of the region's nearly 1·9 billion people. Kasai's strong track record in dealing with health security threats such as severe acute respiratory syndrome (SARS) and avian influenza and his key role in developing and implementing the Asia-Pacific Strategy for Emerging Infectious Diseases (APSED) are viewed as a plus for the region.

[Perspectives] How to grow a human

Thu, 04 Jul 2019 23:00:06 +0000

Over the history of science and medicine, and across cultures—carried in the myths and traditions of populations around the world—attributions of how life is created and how humans could ourselves create life have been fed both by rich imaginings and colourful scientific hypotheses. Take, for example, the early 16th-century German–Swiss physician Theophrastus Philippus Aureolus Bombastus von Hohenheim (better known as Paracelsus), who spent much of his life formulating a method for the creation of human life.

[Perspectives] The rise of the virtualist

Thu, 04 Jul 2019 23:00:06 +0000

From time immemorial, an invariable feature of doctor–patient interaction has been that it takes place in person. But the status quo is changing. A large portion of patient care might eventually be delivered via telemedicine by virtualists, physicians who treat patients they may never meet.

[World Report] Apply to trial Ebola vaccines in DR Congo, says ministry

Thu, 04 Jul 2019 23:00:06 +0000

A WHO expert panel said that vaccines against Ebola virus infection could be used in clinical trials, DR Congo ministry say they are open to this option. Esther Nakkazi reports.

[World Report] Kazakhstan: health after the Nazarbayev era

Thu, 04 Jul 2019 23:00:06 +0000

Health improved under now-former President Nursultan Nazarbayev's 30 year rule, but discontent suggests more progress is needed to fight inequalities. Sharmila Devi and Aliya Uteuova report.

[Comment] Offline: Who should lead UNAIDS?

Thu, 04 Jul 2019 23:00:06 +0000

Who is best qualified to lead an organisation—UNAIDS— that has not only suffered severe reputational loss, but also faces threats to its continuing existence? UNAIDS is a jointly sponsored UN programme that has, in its own words, “led and inspired global, regional, national, and local leadership, innovation, and partnership to ultimately consign HIV to history”. But some observers believe this glorious history is just that—history. Rob Yates was recently appointed head of Chatham House's Centre on Global Health Security.

[Comment] The Wakley–Wu Lien Teh Prize Essay 2019: telling the stories of Chinese doctors

Thu, 04 Jul 2019 23:00:06 +0000

Wu Lien Teh (1879–1960), a Malayan-born Chinese physician, made many firsts in China's medical history. He was one of the first students of Chinese descent to graduate in medicine from the UK's University of Cambridge. Wu published papers in The Lancet and was nominated for the Nobel Prize in Physiology or Medicine. One of the most outstanding of Wu's many contributions to medicine in China and global health was his success in leading the fight against plague in 1910, and his appointment as the chair of the International Plague Conference in 1911.

[Comment] WHO and ITU establish benchmarking process for artificial intelligence in health

Thu, 04 Jul 2019 23:00:06 +0000

Growing populations, demographic changes, and a shortage of health practitioners have placed pressures on the health-care sector. In parallel, increasing amounts of digital health data and information have become available. Artificial intelligence (AI) models that learn from these large datasets are in development and have the potential to assist with pattern recognition and classification problems in medicine—for example, early detection, diagnosis, and medical decision making.1,2 These advances promise to improve health care for patients and provide much-needed support for medical practitioners.

[Comment] Reducing maternal mortality: can elabela help in this fight?

Thu, 04 Jul 2019 23:00:06 +0000

Maternal mortality is an international health-care crisis. A staggering 830 women die daily from pregnancy-related complications1 globally—over 300 000 per year. Pre-eclampsia affects approximately 2–8% of pregnancies worldwide and is a leading cause of maternal morbidity and mortality.2 The Global Strategy for Women's, Children's and Adolescents’ Health aims to reduce global maternal mortality to less than 70 per 100 000 livebirths by 2030.1 In order to accomplish this goal, new treatments to prevent hypertensive disorders of pregnancy are urgently needed.

[Comment] Robotic-assisted training after stroke: RATULS advances science

Thu, 04 Jul 2019 23:00:06 +0000

The Robot Assisted Training for the Upper Limb after Stroke (RATULS) trial by Helen Rodgers and colleagues1 in The Lancet is, to the best of our knowledge, the largest study (n=770) in the field of robot-assisted arm training for people with stroke. Recruiting from four UK sites, this pragmatic, three-arm, randomised controlled trial compared robot-assisted training, enhanced upper limb training (EULT; matched in dose and frequency to robot-assisted training), and lower-dose usual care. The population for this study was 770 individuals aged at least 18 years (mean age 61 years [SD 14]; 468 [61%] men) with first-ever stroke (1 week to 5 years before enrolment) with moderate to severe upper limb impairment.

[Comment] Which to choose, an oral or an injectable glucagon-like peptide-1 receptor agonist?

Thu, 04 Jul 2019 23:00:06 +0000

In The Lancet, Richard Pratley and colleagues describe the results of the PIONEER 4 trial,1 a controlled, double-dummy, double-blind, 52-week phase 3a trial comparing the safety and effects of two glucagon-like peptide-1 (GLP-1) receptor agonists for diabetes therapy. They randomly assigned 711 eligible patients with type 2 diabetes uncontrolled with metformin (with or without additional sodium-glucose co-transporter-2 [SGLT2] inhibitor treatment) to the newly developed oral agonist semaglutide2 (dose escalated to 14 mg once daily; n=285), the once-daily injectable agonist liraglutide (dose escalated to 1·8 mg; n=284), and placebo (n=142).

[Comment] Registering a CD38 antibody upfront for multiple myeloma

Thu, 04 Jul 2019 23:00:06 +0000

The quest to improve the depth and duration of response for patients with newly diagnosed multiple myeloma has led us to four-drug induction over the three-drug approach, involving a proteasome inhibitor, immune modulator (known as IMiD), and dexamethasone, solidified in the USA by the results of SWOG 07771 in the elderly or unfit and IFM-20092 in the young and fit. Adding a monoclonal antibody, such as daratumumab, is a step that our lymphoma colleagues have already successfully taken.3

[Editorial] Creating respectful health care for trans patients

Thu, 04 Jul 2019 23:00:06 +0000

Transgender people face substantial health and health-care disparities that are closely linked to stigma and discrimination. According to the charity Stonewall, 40% of trans people in Britain have had trouble accessing health care because of their gender identity and 32% have experienced unequal treatment by health-care staff. Last month, the Royal College of General Practitioners (RCGP) released a position statement on the role of GPs in caring for gender-questioning and trans patients that outlines the barriers to providing respectful and holistic care.

[Editorial] G20 Osaka: when will global health commitments be realised?

Thu, 04 Jul 2019 23:00:06 +0000

The Group of 20 (G20) Summit took place on June 28 and 29 in Osaka, Japan, amid escalating tensions over trade, climate change, and even the value of liberalism. With the dominant focus on the economy and global trade, especially deals between the USA and China, health discussions failed to make the mainstream media headlines. Indeed, progression on health was disappointing.

Febrile Seizures Tied to High Risk of Mental Illness, Epilepsy

Thu, 04 Jul 2019 13:14:15 +0000

A 30-year follow-up study shows a 30% increased risk of psychiatric disorders among individuals who had three or more febrile seizures as children.
Medscape Medical News

Unique Emotional Challenges Faced by Oncologists

Thu, 04 Jul 2019 12:03:49 +0000

Physicians have the highest suicide rate of any profession, and oncology providers face unique emotional challenges because of their specialty.
Medscape Medical News

Hanging in the Balance: Reports Aim to Propel Obesity Care Forward

Thu, 04 Jul 2019 11:47:41 +0000

"These are critical steps in the evolution of a comprehensive care model for obesity treatment and prevention," says an expert.
Medscape Medical News

'Negative Risk Markers' Seen to Sharpen Targeting of Statins

Thu, 04 Jul 2019 09:02:43 +0000

Low coronary artery calcium scores and other markers of low risk could help individualize guideline-based risk predictions; fewer elderly people could be targeted for preventive statins.
Medscape Medical News

CMS Expands Ambulatory Blood Pressure Monitoring Coverage

Thu, 04 Jul 2019 09:32:12 +0000

Medicare agreed to an AMA-AHA request to cover ABPM for suspected cases of masked hypertension. It also lowered the hypertension threshold for this coverage from 140/90 mm Hg to 130/80 mm Hg.
Medscape Medical News

Effectiveness, Safety Cloud New Female Libido Booster Vyleesi

Thu, 04 Jul 2019 07:26:33 +0000

A significant dropout rate during trials raises questions about how it will fly in the real world.
Medscape Medical News

Лекарства второй свежести

Thu, 04 Jul 2019 10:41:27 +0000

Дорогостоящие онкопрепараты в России лидируют среди фальсифицированных лекарств. Препараты переупаковывают, пускают во вторичную продажу и даже изготовляют в кустарных условиях. Криминальные схемы типичны для всей страны, и решение проблемы надо искать на уровне федерального законодательства, считают эксперты.

Слишком низкий уровень «плохого холестерина» связан с увеличением риска кровоизлияния в мозг

Thu, 04 Jul 2019 09:06:19 +0000

Согласно современным медицинским рекомендациям, уровень холестерина нужно снижать для уменьшения риска сердечных заболеваний. Но результаты нового исследования показывают, что, если уровень холестерина падает слишком низко, это может повысить риск геморрагического инсульта (кровоизлияния в мозг).

Three Judges, One Hearing: At Stake on July 9, the ACA's Future

Wed, 03 Jul 2019 20:20:25 +0000

The appeals court's decision on the viability of Obamacare could come as soon as September.
Medscape Medical News

European Commission Greenlights Drug-Sparing Dovato for HIV

Wed, 03 Jul 2019 19:39:01 +0000

Dovato (dolutegravir and lamivudine), a single-pill, two-drug regimen taken once daily, is noninferior to a three-drug regimen for treatment-naïve adults and children older than 12 with HIV in Europe.
International Approvals

MENTOR: Rituximab Is a Winner in Membranous Nephropathy

Wed, 03 Jul 2019 17:00:19 +0000

The anti-CD20 antibody is clearly superior to cyclosporine in inducing, maintaining proteinuria remission in patients with membranous nephropathy.
Medscape Medical News

CTE Prevalence High...and Not Just in Athletes

Wed, 03 Jul 2019 16:48:24 +0000

The largest study of chronic traumatic encephalopathy (CTE) to date shows that up to 6% of the general population may have CTE, with the highest rates in athletes and males.
Medscape Medical News

FDA Updates Advice on Eating Fish for Pregnant Women, Children

Wed, 03 Jul 2019 15:19:15 +0000

The update does not change recommendations but puts more focus on the health benefits of fish consumption for pregnant women and children.
Medscape Medical News

New Type of TMS Promising for PTSD

Wed, 03 Jul 2019 15:22:08 +0000

Patients who don't respond to psychotherapy or medication for PTSD may benefit from intermittent theta-burst stimulation, a 'second-generation' modality of transcranial magnetic stimulation, new research says.
Medscape Medical News

Generic Drugs Sometimes No Bargain Under Medicare Part D

Wed, 03 Jul 2019 15:35:25 +0000

Policies aimed at closing the 'donut hole' instead raise out-of-pocket costs of generics compared with their brand-name counterparts, especially for high-priced specialty medications.
Medscape Medical News

FDA Approves Selinexor for Refractory Multiple Myeloma

Wed, 03 Jul 2019 15:42:29 +0000

Selinexor is approved in combination with the corticosteroid dexamethasone for the treatment of relapsed/refractory multiple myeloma in patients who are out of treatment options.
FDA Approvals

Keto-Like Diet May Improve Cognition in MCI, Early Alzheimer's

Wed, 03 Jul 2019 14:18:32 +0000

Changing the diet of individuals with mild cognitive impairment or early Alzheimer's to low-carb, high-fat 'ketogenic' diet could positively affect cognitive function, early research shows.
Medscape Medical News

Apple Opens iPhone EHR Feature to All Healthcare Organizations

Wed, 03 Jul 2019 14:47:30 +0000

Any hospital or clinic with a compatible EHR can allow patients to download EHR data to their iPhones for free.
Medscape Medical News

No Repeat Imaging for Most Adrenal Tumors, Call to Change Guidelines

Wed, 03 Jul 2019 11:00:14 +0000

Patients with noncancerous adrenal tumors don't need repeated imaging or hormone tests; they are most likely to succumb to hypertension, dyslipidemia, and type 2 diabetes, suggests a new meta-analysis.
Medscape Medical News

Protein Buildup in the Brain a New Target for Schizophrenia?

Wed, 03 Jul 2019 11:16:53 +0000

Increased protein insolubility is present in the brains of some patients with schizophrenia. The findings may provide a potential new drug target for the disease.
Medscape Medical News

Weight Loss Support Helps People With Fatty Liver Disease

Wed, 03 Jul 2019 10:20:06 +0000

People who have fatty liver disease related to being overweight may get the disease under better control when they get lots of support to lose weight, a research review suggests.
Reuters Health Information

Are You Concerned About Patients Violating Your Privacy?

Wed, 03 Jul 2019 10:27:14 +0000

Patients' right to privacy is well established. But what about clinicians?
Medscape Reader Polls

Facebook принял меры против постов о «чудо-лекарствах»

Wed, 03 Jul 2019 16:09:01 +0000

Facebook предпринял меры для препятствования продвижения в социальной сети продуктов, связанных со здоровьем, предложение которых основано на вводящих в заблуждение утверждениях. Информация об этом появилась в официальных новостях компании.

Curing Cancer: Easy Politics, Difficult Science

Wed, 03 Jul 2019 09:31:07 +0000

President Trump and presidential candidate Joe Biden pledged to cure the disease that ranks as the nation's second-leading cause of death. Biology and affordability are among the roadblocks.
Kaiser Health News

Higher BMI Linked to Lower ALS Risk

Wed, 03 Jul 2019 07:41:20 +0000

The hypothesis that high body mass index guards against development of amyotrophic lateral sclerosis is reinforced by new research.
Medscape Medical News

Что такое пролежни и как с ними бороться

Wed, 03 Jul 2019 11:00:45 +0000

Уход за лежачим больным – очень непростая задача. Даже небольшие дефекты на коже постепенно превращаются в причиняющие тяжкие страдания пролежни. А присоединившаяся инфекция может привести к гибели пациента. Как правильно ухаживать за обездвиженным больным, чтобы не допустить образования пролежней, рассказал заведующий отделением гнойной хирургии ГКБ №17 Москвы Андрей Аникин.

Группа ведущих ученых выпустила манифест для противодействия антипрививочному движению

Wed, 03 Jul 2019 09:15:01 +0000

Международная группа ведущих ученых в области общественного здоровья в заявлении, опубликованном в Journal of Health Communication, призывает противоборствовать распространению недостоверной информации о вакцинации детей в поисковых системах и социальных сетях. Правительства, по мнению экспертов, должны усилить поддержку программ обязательной иммунизации.

Small Percentage of Ophthalmologists Perform Large Proportion of Intravitreal Anti-VEGF Injections

Wed, 03 Jul 2019 01:02:44 +0000

Three percent of ophthalmologists perform 17% to 31% of all anti-vascular endothelial growth factor (VEGF) injections in the U.S., depending on the agent used, according to new findings.
Reuters Health Information

U.S. Recorded 18 New Cases of Measles Last Week

Wed, 03 Jul 2019 01:02:30 +0000

The United States recorded 18 new measles cases last week, taking the total for the year to 1,095 in the worst outbreak since 1992, federal health officials said on Monday.
Reuters Health Information

Trump Immigration Proposal May Mean Sick Kids Lose Health Benefits

Wed, 03 Jul 2019 01:09:30 +0000

A Trump administration proposal to increase the odds that immigrants will be deemed "public charges" ineligible for government health benefits may result in millions of kids becoming uninsured, a study suggests.
Reuters Health Information

American Caravan Arrives in Canadian "Birthplace of Insulin" for Cheaper Medicine

Wed, 03 Jul 2019 00:48:51 +0000

A self-declared "caravan" of Americans bused across the Canada-U.S. border on Saturday, seeking affordable prices for insulin and raising awareness of "the insulin price crisis" in the United States.
Reuters Health Information

Novel Migraine Drug Safe, Effective in Patients With CV Risk Factors

Tue, 02 Jul 2019 16:52:47 +0000

Pooled data from two phase 3 studies suggest cardiovascular risk factors do not affect the safety or efficacy of the novel migraine drug lasmiditan.
Medscape Medical News

Promising Signs in PCI for the Expanding World of Big Data

Tue, 02 Jul 2019 17:03:13 +0000

Proof-of-concept data suggest machine learning may provide an advantage over traditional statistical methods when prognosticating after PCI and, if validated, could help identify the best use of resources for patients at high risk.
Medscape Medical News

Pain Societies Told to Disclose Ties to Opioid Makers

Tue, 02 Jul 2019 15:06:09 +0000

The US Senate Finance Committee seeks a detailed accounting of all payments that pain societies and advocacy groups have received from opioid manufacturers.
News Alerts

FDA Warning Letters Drop by a Third Under Trump

Tue, 02 Jul 2019 15:13:33 +0000

Some experts say there is cause for concern. The FDA says the numbers shift year to year, that such letters are only one tool the agency uses, and the drop does not signal a change in priorities.
Medscape Medical News

American Pain Society Officially Shuttered

Tue, 02 Jul 2019 15:43:15 +0000

In the face of lawsuits related to the opioid crisis, the leadership of the 40-year-old American Pain Society has made the painful decision to file for bankruptcy and shut its doors.
Medscape Medical News

Алкоголь вредит огромному количеству людей, которые его не употребляют

Tue, 02 Jul 2019 17:55:09 +0000

По словам ученых, женщины гораздо чаще испытывают вред, причиняемый им близкими людьми, включая супругов и партнеров, а также родителями, братья и сестрами. Мужчины же чаще страдают от вреда, причиняемого им посторонними людьми, в том числе в результате драк и нападений пьяных.

Табак и потеря зрения. О чем не знают курильщики

Tue, 02 Jul 2019 18:12:12 +0000

Миллионы курящих людей подвергают свое зрение риску, даже не зная об этом и не получая предупреждений от специалистов. Хотя существует четкая связь между этими проблемами, только один из пяти человек знает об опасности, свидетельствует опрос, проведенный британской Ассоциацией оптиметристов.

Generic vs Brand-Name Levothyroxine: Same Cardiac Event Risk?

Tue, 02 Jul 2019 11:17:10 +0000

'There's been a lot of discussion of generic versus brand L-T4, and this is just one other piece of information in a very large group of patients, but it needs follow-up studies,' says lead author.
Medscape Medical News

Ice Bucket Challenge Fires Up ALS Research 5 Years Later

Tue, 02 Jul 2019 10:34:36 +0000

It has been 5 years since people challenged each other to dump a bucket of ice water on their heads to raise money for Lou Gehrig's disease.
Medscape Medical News

Green Light for CVD Data From DECLARE in Dapagliflozin EU Label

Tue, 02 Jul 2019 09:14:43 +0000

The EMA CHMP gives green light to change EU label for dapagliflozin (Forxiga, AstraZeneca) for type 2 diabetes to include CV outcomes data from DECLARE-TIMI 58.
International Approvals

How the Biology of Lower Socioeconomic Status May Raise CV Risk

Tue, 02 Jul 2019 09:27:44 +0000

It may raise the risk for CV events through upregulation of the amygdala's stress responses, promoting immune activation and arterial inflammation, researchers propose.
Medscape Medical News

Guidelines for Transgender Patients in Primary Care Released

Tue, 02 Jul 2019 06:47:38 +0000

Most primary care providers already have the skills and knowledge necessary to care for this population, one author says.
Medscape Medical News

Federal Court Delays Adoption of ‘Conscience’ Healthcare Rule on Abortion

Tue, 02 Jul 2019 03:07:24 +0000

The U.S. Department of Health and Human Services (HHS) and its opponents in a California lawsuit agreed on Friday to delay implementing a rule that would allow medical workers to decline performing abortions or other treatments on moral or religious grounds, according to a federal court filing.
Reuters Health Information

Ученые обнаружили связь цистита и пиелонефрита с инсультом

Tue, 02 Jul 2019 08:40:33 +0000

По данным нового исследования, опубликованного в журнале Американской кардиологической ассоциации Stroke, некоторые инфекции были определены как возможные триггеры инсульта, причем наиболее сильная связь зафиксирована между инфекциями мочевыводящих путей и ишемическим инсультом.

Antipsychotic Use in Dementia Linked To Increased Mortality

Mon, 01 Jul 2019 14:53:17 +0000

Dementia patients in a new study who received an antipsychotic had a 35% increased risk of mortality; those who also had preexisting diabetes or cardiovascular disease had an even higher risk.
Medscape Medical News

Фигура женщины показывает степень риска развития инфаркта и инсульта

Mon, 01 Jul 2019 20:15:32 +0000

У пожилых женщин с относительно большим количеством жира в области живота более высокий риск развития сердечно-сосудистых заболеваний (ССЗ) по сравнению с женщинами, у которых больше жира в районе бедер. Об этом говорят результаты исследования, опубликованного в European Heart Journal.

Five Things We Found in the FDA's Hidden Device Database

Mon, 01 Jul 2019 13:01:48 +0000

Millions of medical device malfunction and injury reports had been stored in a hidden database for the past two decades. Now 5.7 million incidents have been revealed to the public for the first time.
Kaiser Health News

Cryptosporidiosis Outbreak Rate Continues to Rise

Mon, 01 Jul 2019 13:23:16 +0000

More than one third of the reported outbreaks were linked to waterborne exposure via swimming pools and other recreational venues.
Medscape Medical News

Editing Selfies Linked to Plastic Surgery Acceptance

Mon, 01 Jul 2019 12:25:50 +0000

Use of social media and photo editing of selfies was associated with increased acceptance of facial plastic surgery, a study found.
Medscape Medical News

Patients With MS May Have Greater Risk for Cancer

Mon, 01 Jul 2019 11:20:01 +0000

The higher risk, which was especially notable for cancers of the respiratory and central nervous system, occurred when patients with MS were compared with the general population, researchers say.
Medscape Medical News

Starting Dialysis Worse Than 'Being Hit by a Silent Freight Train'

Mon, 01 Jul 2019 10:39:28 +0000

Those starting dialysis experience a decline in function that is difficult to describe, says one patient, as GOLD results reveal the extent of the burden, not just for patients but for caregivers too.
Medscape Medical News

Dropping Aspirin After PCI: New Studies Published

Mon, 01 Jul 2019 09:22:03 +0000

Two studies, STOPDAPT-2 and SMART-CHOICE, suggest that P2Y12 inhibitor monotherapy after a short period of dual antiplatelet therapy may be the way forward, but more data are required.
Medscape Medical News

Major Bleeding After Lower-Extremity Intervention Exceeds 4%

Mon, 01 Jul 2019 09:29:02 +0000

Substantial variability seen across institutions in this NCDR study, indicating a need for risk-prediction tools and best practices.
Medscape Medical News

Climate Change a Public Health Emergency, Medical Groups Warn

Mon, 01 Jul 2019 04:27:45 +0000

A coalition of professional medical organizations has urged elected officials and the healthcare sector to take swift action against climate change.
Medscape Medical News

БАДы для повышения уровня тестостерона не помогают и могут быть опасны

Mon, 01 Jul 2019 10:15:27 +0000

Мужчинам, желающим повысить свое либидо или нарастить массу тела, не стоит возлагать надежды на повышающие уровень тестостерона добавки, также известные как «Т-бустеры». Согласно результатам исследования, опубликованным в The World Journal of Men's Health, эти альтернативы традиционной заместительной терапии тестостероном могут не иметь необходимых ингредиентов.

«Мы настроены на победу над гепатитом C. Но для этого нужно хорошо финансировать программу»

Mon, 01 Jul 2019 10:46:11 +0000

Санкт-Петербург станет первым городом в России, где в 2020 году вылечат всех подростков, больных хроническим гепатитом C. Это стало возможным, благодаря впервые зарегистрированному в нынешнем году препарату прямого противовирусного действия для детей с 12 лет и решению городских властей выделить на него средства.

«Нет такой профессии, в которой людей уголовно наказывают за ошибки. Кроме медицины»

Sun, 30 Jun 2019 17:39:21 +0000

В Калининграде задержали реаниматолога Перинатального центра по делу о смерти в роддоме в первые сутки недоношенного младенца. Не сумевшего спасти новорожденного ребенка врача обвиняют даже не в халатности, а в «убийстве малолетнего, заведомо находящегося в беспомощном состоянии группой лиц по предварительному сговору» (часть 2 статьи 105 УК РФ).

«Нет такой профессии, в которой людей уголовно наказывают за ошибки. Кроме медицины»

Sun, 30 Jun 2019 17:39:21 +0000

В Калининграде задержали реаниматолога Перинатального центра по делу о смерти в роддоме в первые сутки недоношенного младенца. Не сумевшего спасти новорожденного врача обвиняют даже не в халатности, а в «убийстве малолетнего, заведомо находящегося в беспомощном состоянии группой лиц по предварительному сговору» (часть 2 статьи 105 УК РФ).

Democratic Candidates Put Healthcare Front and Center at Debates

Fri, 28 Jun 2019 21:30:38 +0000

Healthcare topics took up a large portion of the first debates, with all candidates making universal health coverage a central theme of the 2 nights.
Medscape Medical News

Flu Shot Weak This Season, Recs for Catch-up HPV Vaccines

Fri, 28 Jun 2019 18:54:41 +0000

A CDC advisory panel stated that this past season's flu vaccine was only about 30% effective, while recommending a decision-making process for those aged 27 to 45 years to get catch-up vaccinations for HPV.
Medscape Medical News

EU Panel Backs Angiotension II (Giapreza) for Septic Shock

Fri, 28 Jun 2019 16:57:33 +0000

Giapreza is for refractory hypotension in adults with septic or other distributive shock who remain hypotensive despite adequate volume restitution and application of catecholamines.
International Approvals

FDA Expands Indication for Platelet Booster Avatrombopag

Fri, 28 Jun 2019 16:16:57 +0000

Avatrombopag is now indicated for adults with thrombocytopenia and chronic immune thrombocytopenia; it is already approved for adults with thrombocytopenia and chronic liver disease.
FDA Approvals

Hashtag Med: Twitter Weighs In on Dem's Border Call to Action

Fri, 28 Jun 2019 16:21:49 +0000

Tim Ryan's plea during the first Democratic presidential debate for doctors and nurses to volunteer along the US southern border drew swift reaction on Twitter.
Medscape Medical News

EU Panel Curbs Use of Bacterial Lysate for Respiratory Conditions

Fri, 28 Jun 2019 16:49:34 +0000

The EMA committee recommends that bacterial lysate only be used for the prevention of recurrent respiratory infections, with the exception of pneumonia.
News Alerts

Men Ask Most Questions at Conferences, but Awareness Helps

Fri, 28 Jun 2019 15:15:43 +0000

Talking to conference attendees about the question-asking gender gap can help close it, a study has found.
Medscape Medical News

Blood Test for Alzheimer's Disease One Step Closer?

Fri, 28 Jun 2019 13:57:06 +0000

Researchers report progress in the quest to develop a sensitive blood test that reflects beta-amyloid levels in the brain.
Medscape Medical News

Testosterone Therapy Disappoints for Anorexia

Fri, 28 Jun 2019 12:57:33 +0000

Previous research pointed to testosterone as a promising intervention for anorexia, but this study shows it is no more effective than placebo.
Medscape Medical News

CHMP Backs Generic Lacosamide UCB for Partial-Onset Seizures

Fri, 28 Jun 2019 13:13:29 +0000

Lacosamide UCB, a generic version of Vimpat, is for partial-onset seizures with or without secondary generalization in adults and children as young as age 4 years with epilepsy.
International Approvals

Acalabrutinib Now Finding a Role in CLL, Shows Good Tolerability

Fri, 28 Jun 2019 12:35:48 +0000

The second-generation BTK inhibitor shows good tolerability and improved progression-free survival when compared to standard approaches, paving a way for CLL as a new indication.
Medscape Medical News

Исследование: Вакцинация против ВПЧ может искоренить рак шейки матки

Fri, 28 Jun 2019 08:58:22 +0000

Международное исследование, проведенное британскими и канадскими учеными и опубликованное в The Lancet, предоставило убедительные доказательства, что вакцинация против вируса папилломы человека (ВПЧ) эффективно предотвращает рак шейки матки и может способствовать его элиминации.

«Когда педиатры видели результаты этой терапии у взрослых, они могли только завидовать»

Fri, 28 Jun 2019 18:05:33 +0000

В России зарегистрирован препарат прямого противовирусного действия для лечения гепатита C у детей с 12 лет. Это значит, что инновационная терапия, которая спасла сотни тысяч взрослых по всему миру, теперь доступна и для подростков. Почему это можно считать революцией, и как будут лечить до 12 лет, рассказала зав. отделением Клиники ФИЦ питания и биотехнологии Татьяна Строкова.

Healthcare Disparities Have Largely Worsened in Recent Years

Fri, 28 Jun 2019 11:06:41 +0000

The black-white gap has narrowed, but other measures of health equity by demographic subgroups have not changed or have worsened.
Medscape Medical News

EU OKs Liraglutide in Kids; Rejects Romosozumab for Osteoporosis

Fri, 28 Jun 2019 11:23:35 +0000

The CHMP recommended approval of the GLP-1 agonist liraglutide for type 2 diabetes in children aged 10 and older, but it recommended refusal of marketing authorization for osteoporosis agent romosozumab.
International Approvals

Childhood Maltreatment and the Brain: Key Insights

Fri, 28 Jun 2019 11:35:54 +0000

Childhood maltreatment may raise the risk for disorders related to hyper- and hypoactive amygdala response to emotional stimuli, depending on when the abuse happens.
Medscape Medical News

Интенсивные занятия физкультурой после 40 могут сократить риск смерти почти в двое

Fri, 28 Jun 2019 17:53:19 +0000

Новое исследование ученых Кембриджского университета показывает, что в пожилом возрасте слишком много физических упражнений не бывает. Исследование, которое включало почти 15000 граждан Великобритании, показало, что у физически активных людей, увеличивавших длительность упражнений, риск преждевременной смерти снижался почти вдвое.

Supplements for Brain Health Panned

Fri, 28 Jun 2019 10:31:08 +0000

Americans older than 50 years should strongly reconsider the use of supplements as a way of improving or protecting brain health, a new report suggests.
Medscape Medical News

Anticholinergic Drugs Could Account for 10% of Dementia Cases

Fri, 28 Jun 2019 10:47:51 +0000

Further evidence showing that anticholinergic drugs are linked to the development of dementia has come from a new randomized study.
Medscape Medical News

Increased Activity in Middle Age Tied to Lower Mortality

Fri, 28 Jun 2019 09:31:40 +0000

Increased activity in middle age and beyond was tied to lower mortality regardless of past activity and risk factors, a study found.
Medscape Medical News

Many in the United States Have Not Been Tested for HIV

Fri, 28 Jun 2019 08:15:41 +0000

The findings represent a 'missed opportunity' to fully execute HIV screening recommendations, CDC researchers said.
Medscape Medical News

Western Junk Food Diet Linked to Impaired Testicular Function

Fri, 28 Jun 2019 06:53:32 +0000

Eating processed meats, refined grains, and sweets is associated with lower sperm count.
Medscape Medical News

Surgical Safety Checklist Reduces Post-Op Deaths

Fri, 28 Jun 2019 07:32:41 +0000

A surgical safety checklist helped to reduce postoperative surgical mortality rates by more than a third during 20 years, a study found.
Medscape Medical News

The Hidden Costs of Drug Shortages Go Beyond Patient Harm

Fri, 28 Jun 2019 05:53:15 +0000

A new report shows that rising drug shortages are costly to hospitals in labor and clinician time while endangering patients.
Medscape Medical News

Virginia Cardiologist Murdered While on Vacation in Belize

Fri, 28 Jun 2019 06:19:42 +0000

Gary Swank, MD, 53, was medical director of Carilion Clinic's Cardiac Catheterization Lab and an associate professor of internal medicine at the Virginia Tech Carilion School of Medicine in Roanoke.
Medscape Medical News

Half of Physicians Favor Sharing Own Diagnosis With Patients

Fri, 28 Jun 2019 05:09:33 +0000

Male physicians were substantially more likely to favor revealing the information. But numbers were low for both men and women when asked whether they personally disclose such information.
Medscape Medical News

Исследование: Вакцинация против ВПЧ может искоренить рак шейки матки

Fri, 28 Jun 2019 08:58:22 +0000

Международное исследование, проведенное британскими и канадскими учеными и опубликованное в The Lancet, предоставило «убедительные доказательства», что вакцинация против вируса папилломы человека (ВПЧ) эффективно предотвращает рак шейки матки и может способствовать его элиминации.

TAVR Speedier Stenosis Fix Than SAVR in Patients With Prior CABG

Thu, 27 Jun 2019 21:37:28 +0000

In patients who have previously undergone coronary-artery bypass grafting (CABG) and have symptomatic aortic stenosis (AS), transcatheter aortic-valve replacement (TAVR) using the Medtronic Corevalve System may offer advantages over surgical aortic-valve replacement (SAVR).
Reuters Health Information

[Viewpoint] The case of Kavumu: a model of medicolegal collaboration

Thu, 27 Jun 2019 23:00:10 +0000

On July 27, 2018, in a landmark judgment, the High Military Court in the Democratic Republic of the Congo (DRC) upheld the conviction of 11 men, including a provincial lawmaker, who had been found guilty in December, 2017, of crimes against humanity for the rape of dozens of young girls and for murder in the village of Kavumu.1 This decision was the first successful conviction of sexual violence as a crime against humanity in the DRC for a sitting lawmaker. It is the culmination of 5 years of groundbreaking work by many national and international stakeholders, especially by Congolese medical, psychological, and legal professionals.

[Viewpoint] Responding to the Ebola virus disease outbreak in DR Congo: when will we learn from Sierra Leone?

Thu, 27 Jun 2019 23:00:10 +0000

Latest reports from WHO suggest that the Ebola virus disease outbreak in North Kivu and Ituri provinces, DR Congo, is serious and rapidly escalating. As of May 19, 2019, there were 1826 confirmed cases and 1218 deaths, making it the second largest outbreak of Ebola virus disease in history, with a case fatality rate of 66%—much higher than previous outbreaks.1 Jeremy Farrar, director of the Wellcome Trust, has called the situation “terrifying”.2 Although ring vaccination is helping to contain transmission, it requires sufficient coverage of contact individuals and efficacy has been shown only beyond 10 days after vaccination.

[Seminar] Sarcopenia

Thu, 27 Jun 2019 23:00:10 +0000

Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls, functional decline, frailty, and mortality. It occurs commonly as an age-related process in older people, influenced not only by contemporaneous risk factors, but also by genetic and lifestyle factors operating across the life course. It can also occur in mid-life in association with a range of conditions.

[Clinical Picture] Pneumothorax and lung cysts: a family affair

Thu, 27 Jun 2019 23:00:09 +0000

A 43-year-old man was referred to our specialist clinic for α1 antitrypsin deficiency; CT scans showed basal predominant bullae, suggestive of the disease. On review in the clinic, he had no respiratory symptoms. He was a lifelong non-smoker, without any environmental or occupational exposures of note. He reported a history of recurrent bilateral pneumothoraces in his twenties that required bilateral pleurectomies. There was no family history of chronic obstructive pulmonary disease or emphysema.

[Articles] Immunogenicity of full and fractional dose of inactivated poliovirus vaccine for use in routine immunisation and outbreak response: an open-label, randomised controlled trial

Thu, 27 Jun 2019 23:00:09 +0000

fIPV appears to be an effective dose-sparing strategy for routine immunisation and outbreak responses.

[Articles] Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Thu, 27 Jun 2019 23:00:09 +0000

These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention.

[Articles] 6 months versus 12 months of adjuvant trastuzumab in early breast cancer (PHARE): final analysis of a multicentre, open-label, phase 3 randomised trial

Thu, 27 Jun 2019 23:00:09 +0000

The PHARE study did not show the non-inferiority of 6 months versus 12 months of adjuvant trastuzumab. Hence, adjuvant trastuzumab standard duration should remain 12 months.

[Department of Error] Department of Error

Thu, 27 Jun 2019 23:00:09 +0000

Kirkcaldy RD, Workowski KA. Gentamicin as an alternative treatment for gonorrhoea. Lancet 2019; 393: 2474–75—This Comment (published Online First on May 2) should have been published under a CC BY-NC-ND Open Access licence. This correction has been made to the online version as of June 20, 2019.

[Department of Error] Department of Error

Thu, 27 Jun 2019 23:00:09 +0000

Ross JDC, Brittain C, Cole M, et al. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial. Lancet 2019; 393: 2511–20—This Article (published Online First on May 2) should have been published under a CC BY-NC-ND Open Access licence. This correction has been made to the online version as of June 20, 2019.

[Department of Error] Department of Error

Thu, 27 Jun 2019 23:00:09 +0000

Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet 2019; 393: 2636–46—In figure 5 of this Seminar (published Online First on June 3, 2019), the centile curves showing the UK normative grip strength data for men were unclear and have now been emphasised. This correction has been made to the online version as of June 27, 2019, and the printed Seminar is correct.

[Department of Error] Department of Error

Thu, 27 Jun 2019 23:00:09 +0000

Willett W, Rockström J, Loken B, et al. Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems. Lancet 2018; 393: 447–92—The affiliation of Shenggen Fan was incorrectly listed as International Food Policy Research Institute, University of Washington, Seattle, USA. The affiliation has been corrected to International Food Policy Research Institute, Washington DC, USA. This correction has been made to the online version as of June 27, 2019.

[Department of Error] Department of Error

Thu, 27 Jun 2019 23:00:09 +0000

Smolen JS, Pangan AL, Emery P, et al. Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study. Lancet 2019; 393: 2303–11—In the Summary in this Article (published Online First on May 23, 2019), the third sentence of the Methods section should read “…randomly assigned 2:2:1:1 to switch to once-daily monotherapy of upadacitinib 15 mg or 30 mg or to continue methotrexate…”.

[Correspondence] The twin-PhD model contributs to knowledge production in Africa

Thu, 27 Jun 2019 23:00:09 +0000

We welcome the important and timely viewpoint by Sharon Fonn and colleagues1 about the challenges and potential solutions for increasing knowledge production in Africa. We would like to highlight the role of research collaboration and partnership at the individual (micro) level as an additional source of knowledge production in Africa. An example is the twin-PhD model, which invests in individual researchers by twinning doctoral students.

[Correspondence] Promoting critical appraisal skills

Thu, 27 Jun 2019 23:00:09 +0000

In the concluding section of most research reports, there is a unanimous opinion that more research is needed, and indeed, more research is often needed. However, Douglas Altman1 once suggested that “we need less research, better research, and research done for the right reasons”. It is now widely accepted that there is a massive amount of avoidable waste in medical research because of inadequate research prioritisation, conceptualisation, design, execution, analysis, and reporting.2,3 These deficiencies reflect poor training in research design, which is almost an inevitable consequence of inadequate mentoring of students who are expected to do research as part of their education.

[Correspondence] Making all deaths after surgery count – Authors' reply

Thu, 27 Jun 2019 23:00:09 +0000

Safe surgery saves lives and is a cost-effective public health intervention, but it is associated with risks.1 We estimated that, worldwide, more people die within 30 days of surgery than of any disease-specific category of death, with the exception of stroke and ischaemic heart disease.2 Globally, disparities in postoperative death exist, with the majority of deaths occurring in low-income and middle-income countries (LMICs), despite only a minority of global surgeries being done there. High postoperative mortality rates indicate system failures, which are prevalent in LMICs.

[Correspondence] Making all deaths after surgery count

Thu, 27 Jun 2019 23:00:09 +0000

We read with interest the estimated global postoperative death rates by by Dmitri Nepogodiev and colleagues.1 The authors highlighted the importance of routinely measuring surgical outcomes and expanding surgical services, together with initiatives to reduce postoperative death. Additionally, permanent disability should be considered when addressing the burden of surgical procedures. Permanent disability is particularly relevant with regard to neurosurgery, in which postoperative neurological changes could have important consequences in the patient's daily life.

[Correspondence] Making all deaths after surgery count

Thu, 27 Jun 2019 23:00:09 +0000

We welcome the important focus that Dmitri Nepogodiev and colleagues1 bring to surgical safety. The authors estimate that globally, postoperative deaths account for 4·2 million deaths per year (7·7% of total deaths). Nepogodiev and colleagues project an expansion of surgical services in low-income and middle-income countries (LMICs) will result in an additional 1·9 million postoperative deaths per year, assuming that the postoperative mortality rate in LMICs remains constant while surgical services in these countries expand.

[Correspondence] Making all deaths after surgery count

Thu, 27 Jun 2019 23:00:08 +0000

Postoperative death is not unheard of, yet patients hope that such an outcome is unlikely when they require surgery themselves. Dmitri Nepogodiev and colleagues1 estimate that, globally, at least 4·2 million people die each year within 30 days of a surgical procedure—a cause of death known as perioperative mortality, which was a focus of the Lancet Commission on Global Surgery.2 Nepogodiev and colleagues used a complex model for perioperative mortality in different economic regions, making numerous assumptions and calculations since little data on perioperative mortality exists in any setting.

[Correspondence] US sanctions in Venezuela: help, hindrance, or violation of human rights?

Thu, 27 Jun 2019 23:00:08 +0000

We read with interest the Review about Venezuela's public health crisis1 and could not agree more emphatically with the authors. However, the root causes of this economic crisis, specifically, the impact of the US economic sanctions, deserve further inquiry. Since 2014, 43 unilateral, coercive measures have been applied against Venezuela by the US Administration. These have effectively paralysed the economy, blocked oil exportation globally, and frozen Venezuelan financial assets abroad while denying access to international financial systems.

[Correspondence] Ebola, community engagement, and saving loved ones

Thu, 27 Jun 2019 23:00:08 +0000

The importance of community engagement in the control of an Ebola epidemic is often emphasised,1 but how engagement occurs, and with whom, is not always straightforward. Do targeted populations act collectively, with shared values? If engagement means finding local interlocutors, who do they represent? Does linking them to an externally generated policy agenda compromise their roles or transform them into resented, externally empowered agents?

[Obituary] Lotte Theresa Newman

Thu, 27 Jun 2019 23:00:08 +0000

General practitioner and champion of women in medicine. She was born in Frankfurt, Germany, on Jan 22, 1929, and died in London, UK, with Alzheimer's disease on April 26, 2019, aged 90 years.

[Perspectives] Formulas for grief

Thu, 27 Jun 2019 23:00:08 +0000

After 9 years of surgical training, I know how long a finger can survive if amputated from the body. I know how long you should wait before lifting something heavy after surgery. I can determine how much of a drug you need to treat your infection based solely on your bodyweight. There are algorithms for all of that. But I have no idea how long I am supposed to grieve the dead.

[Perspectives] John Nkengasong: long-term vision for Africa CDC

Thu, 27 Jun 2019 23:00:08 +0000

Geographically speaking, microbiologist John Nkengasong has one of the biggest jobs in Africa. As founding Director of the Africa Centres for Disease Control and Prevention (Africa CDC), his sphere of operations stretches from the southern coast of the Mediterranean to the Cape of Good Hope, covering some 1·3 billion people. “This is the kind of job where from the day you're appointed you're in charge of everything”, says Peter Piot, Director of the London School of Hygiene & Tropical Medicine in the UK.

[Perspectives] Acute myocardial infarction

Thu, 27 Jun 2019 23:00:08 +0000

“You need a heart before you can have an attack”, growls the gumshoe Eddie Valiant in the 1988 cartoon-noir Who Framed Roger Rabbit. Valiant has a point, and not just the obvious one: our contemporary concept of an acute myocardial infarction (AMI) makes little sense outside a series of historical frames in which we have come to understand the function of the heart, the connection between symptoms and underlying pathologies, and the tensions between abstract analyses of risk and the experience of a heart attack.

[Perspectives] The potential of general practice

Thu, 27 Jun 2019 23:00:08 +0000

People entering general practice today might not have heard of Julian Tudor Hart (1927–2018), a pioneering general practitioner (GP) who worked in the Welsh valleys in the UK and described the inverse care law. This law was a revolutionary concept in 1971, when it was considered acceptable to talk about inequalities in health and to argue against the injustices in health-care delivery. As a GP myself, working both as an academic and in one of the most deprived areas of inner city Manchester for the past 25 years, I knew of him and met and worked with many people who saw him as one of the giants of post-war general practice.

[World Report] Five candidates in the running to head UNAIDS after Sidibé

Thu, 27 Jun 2019 23:00:08 +0000

A shortlist of five candidates—including four people from Africa—are in the race to become Executive Director of the UN agency. John Zarocostas reports.

[World Report] No cause identified for death of children in Bihar, India

Thu, 27 Jun 2019 23:00:08 +0000

Although consumption of lychee is most likely a contributing factor, the true culprit is probably malnutrition and poor provision of care. Patralekha Chatterjee reports from New Delhi

[World Report] New scorecard reveals Africa's hepatitis cost

Thu, 27 Jun 2019 23:00:08 +0000

The scorecard marks the progress in the region towards the 2030 hepatitis elimination targets. Munyaradzi Makoni reports.

[World Report] US Congress wants to take the surprise out of medical bills

Thu, 27 Jun 2019 23:00:08 +0000

Congress aims to legislate against unexpected medical bills, which can be financially devastating for unsuspecting patients. Susan Jaffe reports.

[Comment] Offline: Global health for militants

Thu, 27 Jun 2019 23:00:08 +0000

Medical students set up temporary first-aid centres during the recent street protests against Hong Kong Chief Executive Carrie Lam's much hated Extradition Bill. They risked attack, arrest, and prosecution. One might therefore ask: for what cause would you risk everything? Your career? Your freedom? Maybe even your family? For those working in global health, the answer to this question depends on the answer to another question: what is global health for? Research, education, and programme implementation.

[Comment] Increasing healthy life expectancy equitably in England by 5 years by 2035: could it be achieved?

Thu, 27 Jun 2019 23:00:08 +0000

In 2018, the UK Government's Secretary of State for Health and Social Care articulated an ambition to increase healthy life expectancy by at least 5 years by 2035 for England, while also reducing the gap in life expectancy between the richest and the poorest groups within the population.1 Although we doubt that England—or indeed any high-income country—could achieve this ambition, we describe a set of policies with the potential to make a major contribution to such a target as part of an expected new prevention strategy for England.

[Comment] Addressing the inactivated poliovirus vaccine shortage

Thu, 27 Jun 2019 23:00:08 +0000

In 2008, the World Health Assembly called for the development of safe “also for production” and more affordable inactivated poliovirus vaccines (IPVs).1 The resolution led to the acceleration of several projects, including the development of IPV produced from Sabin poliovirus strains2 and evaluation of fractional-dose IPV.

[Comment] Restarting antiplatelet therapy after intracerebral haemorrhage

Thu, 27 Jun 2019 23:00:08 +0000

Antithrombotic therapy is a cornerstone of primary and secondary prevention of ischaemic coronary artery disease and stroke; up to 44% of patients who present with spontaneous intracerebral haemorrhage are taking antithrombotics.1,2 Clinicians commonly face the challenging decision of whether to restart antithrombotic therapy and, if so, when because of a perceived increased risk of recurrent intracerebral haemorrhage.2,3 Nevertheless, we know that survivors face a major ongoing risk of death in the decade after an event.

[Editorial] Epilepsy prevention: an urgent global unmet need

Thu, 27 Jun 2019 23:00:07 +0000

On June 20, in collaboration with the International League Against Epilepsy and the International Bureau for Epilepsy, WHO released its first global report on epilepsy calling for urgent actions to prioritise the condition as a public health concern. Epilepsy: A public health imperative highlights major gaps in awareness, diagnosis, treatment, and health policies through a series of appalling numbers. With around 50 million people affected worldwide, epilepsy is one of the most common and serious brain disorders.

[Editorial] Caring for patients who have been tortured in detention

Thu, 27 Jun 2019 23:00:07 +0000

People who have been tortured while in detention are among our most vulnerable patients. Clinicians who care for these patients might likewise feel vulnerable and ill-equipped to manage the complex health-care needs of victims. Torture and detention on their own have health impacts, but together exact a physical and psychological toll on individuals that can be long-lasting and profound. A third of asylum seekers and over 40% of refugees are estimated to be victims of torture. That health-care delivery can trigger memories of trauma, fear of officials, and mistrust of institutions compounds the challenges clinicians face in caring for people who have been tortured in detention.

[Editorial] Refugee health is a crisis of our own making

Thu, 27 Jun 2019 23:00:07 +0000

Another World Refugee Day has passed, and the number of displaced people around the world is at its highest ever. The wellbeing of those fleeing their homes because of persecution, poverty, and war to seek a better life elsewhere, although guaranteed by ratified international human rights standards and conventions, is still under attack. At last month's World Health Assembly meeting, a report entitled Promoting the health of refugees and migrants: draft global action plan, 2019–2023 was discussed.

FDA Recalls Some Medtronic Insulin Pumps Because of Cybersecurity

Thu, 27 Jun 2019 17:54:23 +0000

Patients using the recalled Medtronic's MiniMed 508 insulin pump and MiniMed Paradigm series insulin pumps are being advised use a different model.
News Alerts

Fewer Young Women Getting Pelvic Exams, CDC Says

Thu, 27 Jun 2019 18:32:36 +0000

Rates of pelvic examinations among American women of reproductive age have fallen over the past 30 years.
Medscape Medical News

Food Insecurity Tied to Higher Migraine Risk in Young Adults

Thu, 27 Jun 2019 17:00:08 +0000

Young adults who are food insecure are twice as likely to suffer from migraine, according to new research.
Reuters Health Information

Dutch Police Seize 2.5 Tons of Meth, in Largest European Haul of Drug

Thu, 27 Jun 2019 17:20:16 +0000

Dutch police said on Wednesday they had seized 2.5 tons of methamphetamine, in what they said was the largest haul of the drug to date in Europe, with a street value estimated in the "hundreds of millions of euros."
Reuters Health Information

Intranasal Bacteriophage Shows Promise Against S. Aureus Chronic Rhinosinusitis

Thu, 27 Jun 2019 17:20:30 +0000

Intranasal bacteriophage therapy appears to be safe and well tolerated and has promising preliminary efficacy in patients with chronic rhinosinusitis (CRS) due to Staphylococcus aureus, according to results from a phase 1 first-in-human, single-arm trial.
Reuters Health Information

Trump Immigration Policy Tied to Poor Health in US-Born Teens

Thu, 27 Jun 2019 17:07:10 +0000

The Trump administration's 'hostile' immigration policy has had an adverse impact on the health of US-born teens with immigrant parents, new research shows.
Medscape Medical News

EU Court Orders Countries Take Hard Line on Air Quality

Thu, 27 Jun 2019 15:55:15 +0000

The European Union's top court ruled on Wednesday that cities needed to act if pollution levels were exceeded in a single black spot rather than based on an average across a region, taking a hard line in a case brought by Brussels residents.
Reuters Health Information

Afghanistan Records 10th Polio Case in 2019 as Security Worsens-Officials

Thu, 27 Jun 2019 16:00:48 +0000

Afghanistan, one of the last countries in the world where polio is still endemic, has registered its 10th case this year, with most coming in southern regions where Taliban militants have wide control, a senior health official said on Wednesday.
Reuters Health Information

Mass Ivermectin Therapy Dramatically Cuts Scabies Cases at 2 Years - Updated Study

Thu, 27 Jun 2019 16:00:30 +0000

Two doses of oral ivermectin administered throughout the population is more effective at dealing with outbreaks of scabies than mass treatment with topical permethrin or administering permethrin cream to affected people and their contacts, according to a new two-year report published online by The New England Journal of Medicine.
Reuters Health Information

Ex-USC Gynecologist Arrested in Los Angeles on Sexual Assault Charges

Thu, 27 Jun 2019 15:55:35 +0000

Los Angeles police arrested a former University of Southern California gynecologist on Wednesday on charges of sexually assaulting 16 patients, authorities said, in a case that has already resulted in a $215 million civil settlement.
Reuters Health Information

FDA Approves First Drug for Neuromyelitis Optica

Thu, 27 Jun 2019 15:56:12 +0000

The US Food and Drug Administration has approved eculizumab for the first treatment of adult patients with the rare autoimmune disease neuromyelitis optical spectrum disorder (NMOSD).
FDA Approvals

Double Antithrombotic Therapy Best for PCI Patients With AF

Thu, 27 Jun 2019 16:18:44 +0000

A new network meta-analysis finds that a NOAC plus a P2Y12 inhibitor alone may be the best antiplatelet strategy for these high-risk patients.
Medscape Medical News

ARB Concerns Continue as Macleods Pulls Contaminated Losartan

Thu, 27 Jun 2019 16:24:49 +0000

The recall comes amid renewed concerns after a recent expanded recall and the discovery of a fourth potential carcinogen in another commonly used hypertension and heart failure medication.
Medscape Medical News

How Doctors Talk About Bodies Can Have Profound Effects on Patients

Thu, 27 Jun 2019 14:51:02 +0000

Whether they mean to or not, physicians can end up communicating distorted messages about bodies that become internalized through repetition, particularly by individuals who develop chronic conditions early in life, according to an opinion piece in JAMA Pediatrics.
Reuters Health Information

Juul Loses Home Turf as San Francisco Bans E-Cigarette Sales

Thu, 27 Jun 2019 14:51:20 +0000

San Francisco will become the first major city in the United States to ban the sale of e-cigarettes as officials look to control the rapid uptick in teenage use of nicotine devices made by companies such as Juul Labs Inc.
Reuters Health Information

Opioid Use Booming as Tramadol Crisis Emerges in Africa - U.N. Drug Report

Thu, 27 Jun 2019 15:38:27 +0000

Synthetic opioid use is booming, the United Nations said on Wednesday in a worldwide drug report that showed deaths in the United States from overdoses still rising and a "crisis" of tramadol use emerging in parts of Africa.
Reuters Health Information

Smoking Hikes STEMI Risk, Especially in Young Women

Thu, 27 Jun 2019 14:39:17 +0000

A new study finds that smoking is an independent risk factor for MI in all ages, but is higher for women — and particularly younger women — than for men.
Medscape Medical News

Clinician Talk Training Is 'Game-Changing Experience'

Thu, 27 Jun 2019 10:58:24 +0000

Communication skills are different from doctoring skills, but they can be learned, and proper evidence-based training with role play can be 'game changing.'
Medscape Medical News

Препараты против холестерина могут повышать риск сахарного диабета в два раза

Thu, 27 Jun 2019 17:26:22 +0000

Новое американское исследование показало, что у пациентов, которым назначали статины, препараты для снижения уровня холестерина, риск развития сахарного диабета 2 типа, повышался как минимум вдвое.

High BP Early in Pregnancy Linked to Birth Risks

Thu, 27 Jun 2019 09:00:43 +0000

High blood pressure during the first trimester of pregnancy was linked to higher risk for gestational hypertension and preeclampsia, a study found.
Medscape Medical News

Страховщики и медики призывают граждан не игнорировать диспансеризацию

Thu, 27 Jun 2019 14:35:27 +0000

В рамках диспансеризации в 2018 году было выявлено 26 тысяч злокачественных новообразований, из которых чуть более половины – на первой и второй стадии. Треть из тех, у кого рак был обнаружен на третьей-четвертой стадии – это люди, ранее не обращавшиеся за медицинской помощью.

Распространенный антисептик связали с риском переломов у женщин

Thu, 27 Jun 2019 09:36:14 +0000

Воздействие антисептика триклозана, который часто встречается в косметике, зубной пасте и таких продуктах, как игрушки и одежда, может привести к повышенному риску развития остеопороза у женщин. Об этом свидетельствует исследование, опубликованное в Journal of Clinical Endocrinology & Metabolism.

Midwifery Students Use Augmented Technology to Improve Clinical Skills

Wed, 26 Jun 2019 15:52:06 +0000

Midwifery students in London are learning to bring new life into the world in a radically new way with the help of augmented reality (AR) technology.
Reuters Health Information

Med Student Protests May Mean No New Doctors in Morocco in 2019

Wed, 26 Jun 2019 17:29:00 +0000

Public medical school students began staging sit-ins in March of this year, and reportedly almost 100% boycotted final exams.
Medscape Medical News

FDA OKs First Treatment for Chronic Rhinosinusitis With Polyps

Wed, 26 Jun 2019 17:32:40 +0000

Dupilumab is the first treatment approved for inadequately controlled chronic rhinosinusitis with nasal polyps.
FDA Approvals

Drug-Disposal Bag Helps Families Properly Dispose of Unused Opioids After Kid’s Surgery

Wed, 26 Jun 2019 15:57:03 +0000

Providing drug-disposal bags increases the likelihood that families will properly dispose of unused opioids after their children's surgery, researchers report.
Reuters Health Information

Vitamin Deficiencies May Be the Only Sign of Celiac Disease

Wed, 26 Jun 2019 16:03:36 +0000

Adults with undiagnosed celiac disease often have nutrient deficiencies as the only sign of the condition, researchers say.
Reuters Health Information

Illinois Joins 10 Other U.S. States in Legalizing Recreational Marijuana

Wed, 26 Jun 2019 16:10:46 +0000

Illinois on Tuesday became the 11th U.S. state to legalize the recreational use of marijuana by adults after Governor J.B. Pritzker signed into law a bill that also provides for the removal of certain previous drug convictions and will generate new revenue for the financially troubled state.
Reuters Health Information

Yes, Counting Steps Might Make You Healthier

Wed, 26 Jun 2019 16:33:52 +0000

People who track their daily steps may not only be more active, they may also be less likely to develop health problems that lead to events like heart attacks or broken bones, a new study suggests.
Reuters Health Information

Tobacco, Vape Shops Sell More to Minors Than Other Retailers

Wed, 26 Jun 2019 16:24:06 +0000

U.S. regulations require retailers to check ID for everyone under age 27 who tries to buy tobacco products, but half of tobacco and vape shops don't do this, a 2018 study of California retailers suggests.
Reuters Health Information

One in Four US Cardiologists Burned Out, Run Down

Wed, 26 Jun 2019 16:20:24 +0000

Burnout rates were highest in mid-career and among women, but do appear lower relative to other medical specialties.
Medscape Medical News

Proactive Drug Monitoring Improves Outcomes in Kids With Crohn’s

Wed, 26 Jun 2019 15:13:22 +0000

Proactive therapeutic-drug monitoring (TDM) in children with Crohn's disease on adalimumab reduces clinical exacerbations compared to reactive TDM, a randomized controlled trial shows.
Reuters Health Information

Top Cath and EP Lab Directors Receiving 'Notable' Industry Dollars

Wed, 26 Jun 2019 15:29:32 +0000

Almost one-third of cath lab directors and almost half of EP lab directors received payments of $10,000 or more from industry in 2017, a new analysis of the Open Payments Program database shows.
Medscape Medical News

In Secret, Seniors Discuss 'Rational Suicide'

Wed, 26 Jun 2019 13:55:24 +0000

Running counter to the efforts of suicide prevention experts and many religious and social norms, some seniors are quietly exploring the option of turning to suicide when they feel they've lived long enough.
Kaiser Health News

Akorn Gets Another FDA Warning Letter, Shares Slide

Wed, 26 Jun 2019 13:15:19 +0000

Akorn Inc said on Tuesday it received a warning letter from the U.S. Food and Drug Administration regarding its manufacturing facility in New Jersey, the latest in a string of setbacks for the generic drugmaker, sending its shares down nearly 13%.
Reuters Health Information

FDA Declines to Approve Acer Therapeutics' Treatment for Rare Genetic Disorder

Wed, 26 Jun 2019 13:20:26 +0000

Acer Therapeutics Inc said on Tuesday its treatment for a severe, rare genetic disorder that can cause blood vessels to fatally rupture was declined approval from the U.S. Food and Drug Administration.
Reuters Health Information

Brief 'Brain Training' Rapidly Boosts Neural Networks

Wed, 26 Jun 2019 12:38:41 +0000

The first study of its kind shows that brief motor imagery training can prompt structural changes in white matter and increase functional connectivity in the brain.
Medscape Medical News

Processed Foods During Pregnancy May Be Linked to Autism

Wed, 26 Jun 2019 11:16:48 +0000

Preliminary research suggests that high levels of propionic acid, a preservative used in processed foods, alters neuronal development in the fetal brain, possibly contributing to autism.
Medscape Medical News

Can Caffeine Help Tackle Obesity via Brown Fat Activation?

Wed, 26 Jun 2019 11:25:04 +0000

"The potential implications of our results are pretty big…brown fat could potentially be part of the solution in tackling [the obesity epidemic]," says the author of a study. But an expert disagrees.
Medscape Medical News

Новые данные: ЭКО увеличивает риск рака молочной железы

Wed, 26 Jun 2019 17:26:48 +0000

Как показало исследование Копенгагенского университета, женщины, родившие детей при помощи ЭКО, чаще заболевают раком молочной железы. Результаты были представлены на ежегодной встрече Европейского общества репродукции человека и эмбриологии в Вене.

How Often Are You Unsure of Diagnoses?

Wed, 26 Jun 2019 09:59:39 +0000

A recent study suggests physicians are overconfident about their rates of diagnostic error.
Medscape Reader Polls

What's Hot at EAN 2019?

Wed, 26 Jun 2019 10:29:32 +0000

Neuroinflammation, an emerging hot topic in the field, is the overarching theme of the European Academy of Neurology, the biggest general neurology conference in Europe.
Medscape Medical News

Vitamin D Recommendations Miss the Mark

Wed, 26 Jun 2019 09:06:58 +0000

Results of the VITALE study are in and they challenge current guidelines for kidney transplant patients and push doses of oral cholecalciferol higher.
Medscape Medical News

Chemical in Toothpaste Tied to Osteoporosis in Women

Wed, 26 Jun 2019 09:35:27 +0000

Exposure to triclosan, common in household products such as soaps and toothpaste but recently banned in hand sanitizers, correlates with lower bone mineral density and prevalence of osteoporosis in US women.
Medscape Medical News

С 2021 года полисы ОМС станут цифровыми

Wed, 26 Jun 2019 13:59:29 +0000

Наравне с электронными, останутся в силе и бумажные полисы, а также пластиковые карточки с чипом – граждане смогут выбрать ту форму полиса ОМС, которая им будет удобна.

Spirometry Cutoff Predicts COPD Hospitalization, Death

Wed, 26 Jun 2019 07:23:01 +0000

The guideline-recommended FEV1:FVC cutoff of lower than 0.70 accurately diagnoses clinically significant COPD and predicts COPD-related hospitalization and death, a study found.
Medscape Medical News

Фаст-фуд приводит к ухудшению качества спермы

Wed, 26 Jun 2019 13:37:14 +0000

Пицца, бургеры, картофель фри и другая переработанная пища может приводить к постоянному снижению количества сперматозоидов в сперме молодых людей, даже если они в хорошей физической форме. Гарвардское исследование, которое обнаружило эту связь, должно быть представлено на ежегодной конференции Европейского общества репродукции и эмбриологии человека.

Teens With Strong Connections at Home and School May Become Healthier Adults

Tue, 25 Jun 2019 22:54:13 +0000

Teens who feel understood by their parents and teachers may grow up to be healthier adults, a U.S. study suggests.
Reuters Health Information

Personalized Music Playlists Could Help Dementia Patients

Tue, 25 Jun 2019 17:22:51 +0000

Personalized music playlists that rekindle memories of childhood and happy moments may bring joy to dementia patients, because music can activate parts of the brain not affected by the disease, experts say.
Reuters Health Information

Higher Risk of Kidney Failure in Older Donors With Hypertension

Tue, 25 Jun 2019 17:00:36 +0000

Study finds increased 15-year risk of ESRD in older kidney donors with hypertension compared to those without. Experts stress absolute risk of ESRD was small and should not prevent donation.
Medscape Medical News

U.S. Records 33 New Measles Cases, Mostly in New York State

Tue, 25 Jun 2019 16:20:05 +0000

Thirty-three new measles cases were recorded in the United States last week, most of them in New York, federal health officials said on Monday, bringing the number of confirmed cases this year to 1,077 in the worst U.S. outbreak of the virus since 1992, when 2,126 cases were recorded.
Reuters Health Information

U.S. Supreme Court to Hear Insurers' Bid for $12 Billion in Obamacare Money

Tue, 25 Jun 2019 16:21:13 +0000

The U.S. Supreme Court on Monday agreed to decide whether insurers can seek $12 billion from the federal government under a program set up by the Obamacare law aimed at encouraging them to offer medical coverage to previously uninsured Americans.
Reuters Health Information

Teleflex Recalls Endotracheal Tubes Worldwide After Reports of 4 Deaths

Tue, 25 Jun 2019 16:19:05 +0000

Teleflex Inc said on Monday it plans to recall some lots of its Hudson RCI Sheridan endotracheal tubes following reports of four deaths.
Reuters Health Information

New Drugs Could Overwhelm Infusion Centers' Capacity

Tue, 25 Jun 2019 16:18:32 +0000

The rubber band is already stretched tight, infusion center leaders warn, and adding new options for postpartum depression and Alzheimer's disease could snap the system.
Medscape Medical News

Clinicians at Stem Cell Clinics Often Lack Credentials

Tue, 25 Jun 2019 16:49:39 +0000

Researchers found that many clinics offering unapproved stem cell interventions don't employ physicians trained to treat the conditions for which they advertise treatments.
Medscape Medical News

Circulation Research Names New Editor-in-Chief

Tue, 25 Jun 2019 15:38:13 +0000

Jane Freedman, MD, plans to broaden the scientific scope of the journal, boost its online presence, and have greater interface with early and mid-career scientists.
Medscape Medical News

FDA Warns More Kratom Makers Over Illegal Sales, False Claims

Tue, 25 Jun 2019 14:01:53 +0000

The FDA continues its crackdown on "unscrupulous" vendors of unapproved kratom products with false claims that they can treat opioid addiction or other problems.
News Alerts

Journal Publishes Concern About Study Using Forced Organ Donation

Tue, 25 Jun 2019 12:54:31 +0000

An earlier Australian study urges medical journals to retract transplantation studies that likely used organs harvested from executed Chinese prisoners.
Medscape Medical News

'Out-of-the-Box' Approaches Needed for Glioblastoma

Tue, 25 Jun 2019 11:45:00 +0000

More radical approaches to the treatment of glioblastoma are called for as long-term survival remains grim and unchanged, despite efforts to improve outcomes for patients with this disease.
Medscape Medical News

Часто назначаемую группу лекарств связали с увеличением риска деменции на 50 процентов

Tue, 25 Jun 2019 17:17:49 +0000

Как отметили ученые, у людей в возрасте 55 лет и старше, которые ежедневно принимали сильные антихолинергические препараты в течение трех и более лет, риск развития деменции увеличился на 50%.

Растительная привела к ремиссии болезни Крона у пациента

Tue, 25 Jun 2019 17:37:46 +0000

При многих хронических заболеваний, включая диабет, ишемическую болезнь сердца и ревматоидный артрит, диета, богатая фруктами, овощами, бобовыми и цельнозерновыми продуктами, важна как для лечения, так и для профилактики. Как говорит отчет, опубликованный в журнале Nutrients, при болезни Крона, растительная диета тоже очень полезна для ремиссии заболевания.

Final CMS Decision on TAVR Reimbursement

Tue, 25 Jun 2019 09:30:08 +0000

CMS revises thresholds set for hospitals to qualify and maintain Medicare payment for TAVR amid rising interest in this approach to aortic stenosis.
Medscape Medical News

New Standards Set for 'Wild West' Infusion Centers

Tue, 25 Jun 2019 08:49:41 +0000

Best-practices for infusion providers will help set the industry bar as the number of outpatient sites grows.
Medscape Medical News

Team Model, Big Data Bring Precision Medicine to Primary Care

Tue, 25 Jun 2019 07:07:16 +0000

Collection of patient data and an eclectic team approach introduced precision medicine into primary care.
Medscape Medical News

"Карцинома" в легком 50-летнего мужчины оказалась игрушкой, которую он вдохнул в детстве

Tue, 25 Jun 2019 12:12:47 +0000

Во время операции по удалению бронхогенной карциномы одному из своих пациентов, вместо опухоли врачи обнаружили игрушечный дорожный конус, который пациент проглотил еще ребенком в 1974 году. Пластмассовый игрушечный конус оказался в правом легком человека, и в течение 40 лет его никто не замечал.

Camp Prep Can Make Summers Better for Kids

Mon, 24 Jun 2019 18:17:10 +0000

Kids may have a much better - and safer - time at summer camp when parents plan ahead to make sure programs are a good fit for their child and capable of handling any health issues that may arise, U.S. pediatricians say.
Reuters Health Information

Conservative Management Favored for Most Pediatric Mandibular Fractures

Mon, 24 Jun 2019 18:11:14 +0000

In young children with mandibular fractures, conservative management with observation or maxillomandibular fixation (MMF) and soft diet is more common than open reduction internal fixation (ORIF), researchers say.
Reuters Health Information

Average Pregnant Woman in US May Have Poor Nutrition

Mon, 24 Jun 2019 17:50:19 +0000

Many pregnant women in the U.S. may not be getting enough of certain crucial nutrients, while others may be getting too much, a new study suggests.
Reuters Health Information

Trump Outlines Goals for Healthcare Price Transparency

Mon, 24 Jun 2019 17:39:42 +0000

President Trump on Monday called for more clear disclosure of medical expenses. Democratic presidential contenders may also delve into healthcare costs during debates later this week.
News Alerts

Hydroxyurea Remains Underused in Children With Sickle Cell Disease

Mon, 24 Jun 2019 16:01:34 +0000

Despite recent increases in use of hydroxyurea for sickle cell disease (SCD), only about one in four children with SCD received hydroxyurea in 2015, according to an analysis of Medicaid data.
Reuters Health Information

Philadelphia Refinery Blast Puts New Spotlight on Toxic Chemical

Mon, 24 Jun 2019 14:01:44 +0000

Massive explosions that engulfed a Philadelphia refinery in flames on Friday has renewed concerns about the oil industry's use of a highly toxic chemical to make high-octane gasoline at plants in densely populated areas.
Reuters Health Information

Missouri Won't Renew Abortion Clinic's License, but Judge Blocks Immediate Closure

Mon, 24 Jun 2019 13:33:47 +0000

Missouri health officials refused to renew the license of the state's only abortion clinic on Friday, but the clinic will remain open for now as a judge left in place an injunction blocking its closure.
Reuters Health Information

Venetoclax for Myeloma: Trial on Hold, Now Details of Benefit

Mon, 24 Jun 2019 13:03:59 +0000

Although the BELLINI trial was put on partial hold, the trial was allowed to continue for patients for whom the addition of venetoclax showed benefit. New data now identify this subgroup.
Medscape Medical News

FDA OKs Botox for Upper Limb Spasticity in Children

Mon, 24 Jun 2019 13:38:28 +0000

Botox is the first neurotoxin to be approved in the US to treat upper limb spasticity for pediatric patients aged 2 years and older.
FDA Approvals

В США одобрили лекарство против снижения сексуального влечения у женщин

Mon, 24 Jun 2019 18:58:42 +0000

Управление по контролю качества пищевых продуктов и лекарственных препаратов США (FDA) одобрило продажу нового лекарства, предназначенного для усиления сексуального желания у женщин в предклимактерическом периоде.

Acute Encephalitis Syndrome Blamed for Preventable Child Deaths in India

Mon, 24 Jun 2019 12:04:32 +0000

Five-year-old Soni Khatun was playing in the midday sun last week when she began to vomit and lose feeling in her hands. Her mother, a poor laborer living in rural India, borrowed money to take her to hospital.
Reuters Health Information

Targeted Therapies Linked to Survival Benefits for Older Patients With Advanced Renal Cancer

Mon, 24 Jun 2019 12:12:33 +0000

Targeted therapies were associated with "modest survival advantages" in elderly Medicare patients with metastatic renal cell carcinoma (mRCC) in a retrospective study.
Reuters Health Information

Step Therapy Costs Patient Vision in Right Eye

Mon, 24 Jun 2019 12:46:21 +0000

Cost- and formulary-driven treatment switches — both pressing policy issues — can alter the course of shared decisions between physicians and patients, sometimes with unintended consequences.
Medscape Medical News

Market in Pre-Owned Diabetic Strips Worries Experts

Mon, 24 Jun 2019 10:48:04 +0000

Patients who have a surplus of diabetes 'test strips' are selling them to companies for subsequent resale to those in need. California regulates the supply chain of diabetes products to prevent fraud.
Georgia Health News

PIONEER 5: Oral Semaglutide for Diabetes With Moderate CKD

Mon, 24 Jun 2019 11:37:15 +0000

Oral semaglutide, the investigational first oral GLP-1 receptor agonist, could expand currently suboptimal treatment options for patients with type 2 diabetes and moderate renal impairment.
Medscape Medical News

Early Onset Type 1 Diabetes May Affect Brain Development in Kids

Mon, 24 Jun 2019 09:50:36 +0000

The decrements are linked to hyperglycemia, suggesting the recommended HbA1c target of < 7.5% in children may be too lenient.
Medscape Medical News

Early Onset Type 1 Diabetes May Affect Brain Development in Kids

Mon, 24 Jun 2019 09:50:36 +0000

The decrements are linked to hyperglycemia, suggesting that the recommended HbA1c target of 7.5% in children may be too lenient.
Medscape Medical News

Endometriosis: Long-term Opioids, Concomitant Benzos Common

Mon, 24 Jun 2019 07:58:30 +0000

Women with endometriosis were more likely to use opioids for a long period and to use benzodiazepines concomitantly compared with women who did not have endometriosis, a study found.
Medscape Medical News

MedPAC Wants to End 'Incident-to' Billing by APRNs, PAs

Mon, 24 Jun 2019 07:07:38 +0000

In a report, the influential panel estimated Medicare savings of as much as $5 billion over 5 years from a proposed change to APRN and PA billing.
Medscape Medical News

Ученые рассказали о влиянии низкого и высокого содержания железа в организме на здоровье

Mon, 24 Jun 2019 11:13:21 +0000

Глобальное международное исследование выявило влияние на здоровье как низкого, так и высокого содержания железа в организме – новости оказались неоднозначными. В этом исследовании использованы генетические и клинические данные британского Биобанка для изучения роли железа в 900 заболеваниях.

Сезон диареи

Mon, 24 Jun 2019 11:30:39 +0000

Лето – сезон острых кишечных инфекций, от которых, по данным ВОЗ, ежедневно в мире погибает 500 взрослых и 4300 детей. Среди причин инфекционной диареи лидируют быстро размножающиеся в плохо обработанных продуктах животного происхождения норовирусы, сальмонеллы и патогенные кишечные палочки, а также афлотоксин, содержащийся в заплесневевшем хлебе.

Peritoneal Carcinomatosis Profiles Highlight Gastric Cancer Targets

Sat, 22 Jun 2019 17:02:59 +0000

Sequencing of whole exome and transcriptome of peritoneal carcinomatosis (PC) in patients with gastric adenocarcinoma (GAC) has given novel insights and opened up new therapeutic opportunities, according to Texas-based researchers.
Reuters Health Information

Teen 'Sexting' May Not Always Spell Trouble

Sat, 22 Jun 2019 16:53:18 +0000

While teen sexting is linked to increased odds of certain types of risky behavior, a new analysis of research to date on the impact of sexually explicit content on adolescent health also suggests there's a lot we still don't know.
Reuters Health Information

When Coronary CTA Is Most Appropriate for Suspected Heart Disease

Sat, 22 Jun 2019 16:29:51 +0000

New research helps zero in on which patients with suspected coronary artery disease (CAD) will derive the most benefit from coronary computed tomography angiography (CTA).
Reuters Health Information

U.S. Mine Regulator Says No Rush on Silica Limits, Despite Black Lung Worries

Sat, 22 Jun 2019 16:23:17 +0000

The head of the U.S. federal agency in charge of mine safety said on Thursday he has no plans to fast-track new limits for coal miner exposure to silica dust because he believes exposure rates are already falling.
Reuters Health Information

Dyspnea Not Necessarily Due to a Heart Problem in Older Patients

Sat, 22 Jun 2019 16:20:26 +0000

Dyspnea is multifactorial in older adults and may be associated with obesity or other conditions, a cross-sectional study suggests.
Reuters Health Information

Dr Eric Rubin to Take the Helm at NEJM

Sat, 22 Jun 2019 09:16:00 +0000

The new editor will face challenges in managing conflicts of interest and maintaining a subscription model.
Medscape Medical News

Merck CEO Sees Legal Challenge if U.S. Adopts Drug Pricing Based on Other Countries

Fri, 21 Jun 2019 20:10:12 +0000

Merck & Co Chief Executive Ken Frazier said on Thursday a rule to base the price the U.S. government pays for some prescription drugs in it Medicare program on lower prices in other countries would face legal challenges if adopted.
Reuters Health Information

FDA Approves New Libido-Boosting Drug for Premenopausal Women

Fri, 21 Jun 2019 18:21:35 +0000

Bremelanotide becomes the second FDA-approved drug for hypoactive sexual desire disorder in premenopausal women. It is self-injected at least 45 minutes before sexual activity.
FDA Approvals

FDA Approves New Libido-Boosting Drug for Premenopausal Women

Fri, 21 Jun 2019 18:21:35 +0000

Bremelanotide becomes the second FDA-approved drug for hypoactive sexual desire disorder in premenopausal women. It is self-injected at least 45 minutes before sexual activity.
News Alerts

FDA Expands Use of Symdeko to Younger Children

Fri, 21 Jun 2019 17:51:19 +0000

The FDA has approved tezacaftor/ivacaftor tablets for use in children as young as 6 years with cystic fibrosis with certain genetic mutations in the CFTR gene.
FDA Approvals

Time to Jettison Nearly 400 Medical Practices, Review Says

Fri, 21 Jun 2019 16:07:13 +0000

By building on preious research in this area, the authors say the new list will help to eliminate the use of commonly accepted practices that are of low value and may even harm patients.
Medscape Medical News

Healthcare Workers Often Work While Sick

Fri, 21 Jun 2019 16:36:40 +0000

Most healthcare workers with an acute respiratory illness have worked while sick, despite the risk of transmitting infection to patients and colleagues, a study found.
Medscape Medical News

No Benefit of Vitamin D for CVD Prevention

Fri, 21 Jun 2019 14:54:52 +0000

Despite observational data suggesting a protective effect, a meta-analysis of trials including more than 83,000 participants finds no such effect of vitamin D supplementation.
Medscape Medical News

Could Chinese Cancer Retraction Point to Drive for Higher Standards?

Fri, 21 Jun 2019 14:29:44 +0000

The authors of a scientific article retracted it just months after publication, invoking Chinese regulators as an explanation.
Medscape Medical News

Americans Still Eat Too Much Sausage, Luncheon Meats, Bacon

Fri, 21 Jun 2019 12:26:11 +0000

American consumption of processed meat has not changed for at least 18 years, despite increasing evidence of its risks, a study found.
Medscape Medical News

Diabetes Survival Skills Welcomed by Those Leaving Prison

Fri, 21 Jun 2019 11:37:19 +0000

A diabetes survival skills program aimed at helping former prisoners transfer to the community improves diabetes-related distress and knowledge around insulin use and disease self-management.
Medscape Medical News

Взрыв электронной сигареты раздробил челюсть подростку

Fri, 21 Jun 2019 17:26:13 +0000

Пока идут споры относительно того, является ли курение электронных сигарет более безопасным, чем обычное курение, серьезным поводом для беспокойства стал недавний инцидент. У подростка взорвалась электронная сигарета, выбив ему несколько зубов и сломав челюсть.

Potassium-Removing Drug Effective in Dialysis Patients

Fri, 21 Jun 2019 10:39:05 +0000

Sodium zirconium cyclosilicate effectively treats hyperkalemia in patients receiving hemodialysis for end-stage kidney disease, and no new safety concerns were observed in the phase 3 DIALIZE study.
Medscape Medical News

U.S. Appeals Court Lets Trump Abortion Referral 'Gag Rule' Take Effect

Fri, 21 Jun 2019 09:37:41 +0000

A federal appeals court on Thursday cleared the way for the Trump administration to enforce a controversial rule barring clinics that receive federal funds for family planning services from referring patients to abortion providers.
Reuters Health Information

Gynecologic Oncologist Faces Criminal Charges for Sexual Assault

Fri, 21 Jun 2019 08:11:18 +0000

A lawsuit has been filed against a UCLA gynecologic oncologist who is also facing criminal charges for sexual assault.
Medscape Medical News

IVUS Bests Angiography to Guide Stenting in CKD: ULTIMATE

Fri, 21 Jun 2019 08:47:02 +0000

The ULTIMATE trial showed IVUS superior to angiography-guided DES implantation, but it was unclear if the benefits applied in kidney disease. This new subanalysis shows it is superior also in CKD.
Medscape Medical News

Женщина забеременела и родила родила нормального ребенка после удаления фаллопиевых труб

Fri, 21 Jun 2019 08:27:39 +0000

Женщина, у которой были удалены фаллопиевы трубы, родила здорового и жизнеспособного ребенка. В медицинской литературе было зарегистрировано только три таких случая, но это первый случай здорового рождения, рассказали врачи изданию Good Morning America.

FDA Panel Backs Labeling Changes for Paclitaxel Devices in PAD

Thu, 20 Jun 2019 20:56:26 +0000

On day 2 of the advisory meeting, the panel agreed labeling of paclitaxel-coated balloons and stents should reflect evidence of a late mortality signal, but disagreed on exact changes.
Medscape Medical News

Oncologist Acts as In-Flight Medic, Gets Extraordinary Response

Thu, 20 Jun 2019 19:25:34 +0000

A frequent flyer has taken care of ill passengers repeatedly on flights, but this time it had an unusual ending.
Medscape Medical News

[Series] Gender equality and gender norms: framing the opportunities for health

Thu, 20 Jun 2019 23:00:09 +0000

The Sustainable Development Goals offer the global health community a strategic opportunity to promote human rights, advance gender equality, and achieve health for all. The inability of the health sector to accelerate progress on a range of health outcomes brings into sharp focus the substantial impact of gender inequalities and restrictive gender norms on health risks and behaviours. In this paper, the fifth in a Series on gender equality, norms, and health, we draw on evidence to dispel three myths on gender and health and describe persistent barriers to progress.

[Series] Disrupting gender norms in health systems: making the case for change

Thu, 20 Jun 2019 23:00:09 +0000

Restrictive gender norms and gender inequalities are replicated and reinforced in health systems, contributing to gender inequalities in health. In this Series paper, we explore how to address all three through recognition and then with disruptive solutions. We used intersectional feminist theory to guide our systematic reviews, qualitative case studies based on lived experiences, and quantitative analyses based on cross-sectional and evaluation research. We found that health systems reinforce patients' traditional gender roles and neglect gender inequalities in health, health system models and clinic-based programmes are rarely gender responsive, and women have less authority as health workers than men and are often devalued and abused.

[Series] Improving health with programmatic, legal, and policy approaches to reduce gender inequality and change restrictive gender norms

Thu, 20 Jun 2019 23:00:09 +0000

Evidence that gender inequalities and restrictive norms adversely affect health is extensive; however, far less research has focused on testing solutions. We first comprehensively reviewed the peer-reviewed and grey literature for rigorously evaluated programmes that aimed to reduce gender inequality and restrictive gender norms and improve health. We identified four mutually reinforcing factors underpinning change: (1) multisectoral action, (2) multilevel, multistakeholder involvement, (3) diversified programming, and (4) social participation and empowerment.

[Clinical Picture] Atypical presentation of classic Kaposi's sarcoma

Thu, 20 Jun 2019 23:00:09 +0000

A 77-year-old woman presented to our department with a 2-year history of multiple, painful, purple lesions over her left breast. Physical examination showed multiple, violaceous, infiltrated papules, nodules, and plaques on her left mammary gland (figure), neck, forearms, legs, hands, and feet. She also had axillary and inguinal lymphadenopathy. She had no medical history prior to this problem. Results of biochemical analyses were normal, and the patient was seronegative for HIV and cytomegalovirus.

[Articles] Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial

Thu, 20 Jun 2019 23:00:09 +0000

Gentamicin is not appropriate as first-line treatment for gonorrhoea but remains potentially useful for patients with isolated genital infection, or for patients who are allergic or intolerant to ceftriaxone, or harbour a ceftriaxone-resistant isolate. Further research is required to identify and test new alternatives to ceftriaxone for the treatment of gonorrhoea.

[Articles] Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials

Thu, 20 Jun 2019 23:00:09 +0000

The performance of new-generation DES in the first year after implantation means that BMS should no longer be considered the gold standard for safety. Further development of DES technology should target improvements in clinical outcomes beyond 1 year.

[Articles] Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study

Thu, 20 Jun 2019 23:00:09 +0000

Based on these data, global goals for reducing the harmful use of alcohol are unlikely to be achieved, and known effective and cost-effective policy measures should be implemented to reduce alcohol exposure.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:09 +0000

GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 2091–138—In this Global Health Metrics paper, affiliation details have been amended for Mina Anjomshoa, Joseph Adel Mattar Banoub, Behzad Khafaei, and Yasin Jemal Yasin; and the declaration of interests statement has been amended for Boris Bikbov.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:09 +0000

GBD 2017 Population and Fertility Collaborators. Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1995–2051—In this Global Health Metrics paper, Haley Comfort has been added to the collaborators list, Mohammad Reza Salahshoor's name has been corrected, affiliation details have been amended for Mohammad Reza Salahshoor and Yasin Jemal Yasin, and the declaration of interests statement has been amended for Boris Bikbov.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:09 +0000

GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1923–94—In this Global Health Metrics paper, affiliations have been amended for Yasin Jemal Yasin, Joseph Adel Mattar Banoub, and Tanuj Kanchan; the declaration of interests statement has been amended for Boris Bikbov; and acknowledgments have been added for providers of smoking relative risk data.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:09 +0000

GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1859–922—In this Global Health Metrics paper, Joan B Soriano has been added to the collaborators list; affiliation details have been amended for Joseph Adel Mattar Banoub, Tanuj Kanchan, and Yasin Jemal Yasin; and the declaration of interests statement has been amended for Boris Bikbov.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1789–858—In this Global Health Metrics paper, Nicholas L S Roberts and W Cliff Mountjoy-Venning have been added to the collaborators list; affiliation details have been amended for Mina Anjomshoa, Joseph Adel Mattar Banoub, and Yasin Jemal Yasin; and the declaration of interests statement has been amended for Boris Bikbov.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736–88—In this Global Health Metrics paper, the affiliations have been amended for Yasin Jemal Yasin, Joseph Adel Mattar Banoub, and Abdullatif Husseini; and the declaration of interests statement has been amended for Boris Bikbov. These corrections have been made to the online version as of June 20, 2019.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1684–735—In this Global Health Metrics paper, Mohammad Reza Salahshoor's name has been corrected; affiliation details have been amended for Mina Anjomshoa, Yasin Jemal Yasin, and Mohammad Reza Salahshoor; and the declaration of interests statement has been amended for Boris Bikbov. Additionally, appendix 2 has been updated.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2018; 392: 1015–35—In this Global Health Metrics paper, Stefan Lorkowski has been added to the collaborators list; affiliation details and a declaration of interests statement for Stefan Lorkowski have also been added. These corrections have been made to the online version as of June 20, 2019.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

Nagot N, Kankasa C, Tumwine JK, et al. Extended pre-exposure prophylaxis with lopinavir–ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trial. Lancet 2016; 387: 566–73—The appendix of this Article, published Online First on Nov 18, 2015, has been corrected as of June 20, 2019.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

Lane R. Katja Iversen: driving force in women's health and gender equity. Lancet 2019; 393: 2293—In this Profile, the fourth sentence of the fourth paragraph should start “UNFPA invited Iversen to become their media specialist and campaign coordinator in New York, USA·” This correction has been made to the online version as of June 20, 2019.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

Villanueva C, Albillos A, Genescà J, et al. β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2019; 393: 1597–608—In the Findings section of this Article (published Online First on March 22, 2019), the data for the reduced incidence of ascites were presented incorrectly, they should read (HR 0·42, 95% CI 0·19–0·92, p=0·03). Likewise, the data presented in the Results section should read the same.

[Department of Error] Department of Error

Thu, 20 Jun 2019 23:00:08 +0000

Piccolo R, Bonaa KH, Efthimiou O, et al. Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 2019; 393: 2503–10—In the key of figure 2 in this Article, published Online First on May 2, 2019, the blue line should have shown bare-metal stents, and the red line should have shown new-generation drug-eluting stents. This correction has been made to the online version as of June 4, 2019, and have been made to the printed Article.

[Correspondence] Boosting quality diagnostics could give Africa better health

Thu, 20 Jun 2019 23:00:08 +0000

We welcome the announcement of the Africa Collaborative Initiative to Advance Diagnostics (AFCAD) by the Africa Centres for Disease Control and Prevention, as reported by Munyaradzi Makoni.1 However, there is a crucial omission in the list of AFCAD focus areas: pneumonia. Not only is pneumonia the leading infectious cause of mortality across Africa, but it is also the leading cause of all mortality, according to the latest Global Burden of Disease estimates.2 In 2017, pneumonia caused an estimated 695 000 deaths, compared with 543 000 deaths attributable to malaria, 529 000 deaths to HIV/AIDS, and 367 000 deaths to tuberculosis.

[Correspondence] The Paris Fire Brigade response to the 2018 Champs-Elysées riots

Thu, 20 Jun 2019 23:00:08 +0000

Following the announcement of an increase in fuel taxes in November, 2018, France was hit by a month of rioting on a scale not seen since 2005.1 Although most of the protests by the so-called yellow vests were peaceful, some radical activists joined the demonstrations with the aim of violence and the intention to damage iconic locations such as the Champs-Elysées.

[Correspondence] The rise of clinical neuroscience in Haiti

Thu, 20 Jun 2019 23:00:08 +0000

Jacquelyn Corley1 reports on the rise of neurology in Haiti to illustrate the neuroscientific landscape of an impoverished Caribbean country that is uniquely situated in historical, sociocultural, and geopolitical terms. Haiti's underappreciated neuroepidemiology is aggravated by resource poverty, workforce limitations, and health system fragmentation. Periodic political, economic, and environmental crises have resulted in decades of human capital flight. Each day, Haitian children suffer or die from a hydrocephalus burden that only came to international attention since 2015.

[Correspondence] Key points to consider in the IMPERIAL trial – Author's reply

Thu, 20 Jun 2019 23:00:08 +0000

We agree with Jim Reekers that the IMPERIAL trial,1 in both device concept and trial design, as well as in its outcome, was unique and important in the endovascular field. We also wholeheartedly support the use of supervised exercise training in peripheral arterial disease patients as a valuable primary and adjunctive tool to improve symptoms and functional capacity, and we are especially pleased at the decision in 2017 by the US Centers for Medicare & Medicaid Services.

[Correspondence] Key points to consider in the IMPERIAL trial

Thu, 20 Jun 2019 23:00:08 +0000

The IMPERIAL study by William Gray and colleagues1 was a very important trial that presented real-life data on drug-eluting stents, and drug-eluting technology in general, in peripheral arterial disease for the first time. Although the intention of the trial was to show non-inferiority with a competing product, this aim was not so simple. 30% of the included patients had moderate claudication, whereas 60% had severe claudication. None of these patients were primarily treated with supervised exercise, which has been shown to improve the average walking distance by around 200 m.

[Correspondence] Children of jihadists: a medical framework for returnees in France

Thu, 20 Jun 2019 23:00:08 +0000

In March, 2017, the French Government established a unique framework to assess the medical and psychological state of children coming to France from the operation zones of terrorist groups, mainly Iraq and Syria.1 The political context has been particularly complex since the 2015 terrorist attacks in France and gives a traumatic tone to our clinical work in the follow-up of these children.

[Correspondence] International drug control system: public health guiding principles

Thu, 20 Jun 2019 23:00:08 +0000

Access to health services for people who use drugs falls short in meeting the global needs, mortality related to drugs is increasing, and epidemics of HIV, hepatitis C, and tuberculosis associated with unsafe drug injection continue to expand.

[Correspondence] The Philip Morris-funded Foundation for a Smoke-Free World: tax return sheds light on funding activities

Thu, 20 Jun 2019 23:00:08 +0000

In September, 2017, Philip Morris International, one of the world's largest tobacco companies, set up the Foundation for a Smoke-Free World, with almost US$1 billion of funding over 12 years.1 The Foundation claims to be an independent scientific body aiming to “accelerate an end to smoking”.2 Yet controversy has surrounded the Foundation since its inception; its claims of legitimacy and independence have been strongly disputed3,4 and WHO5 and hundreds of public health organisations globally6 have taken a strong stance in rejecting collaboration with the Foundation.

[Obituary] Waun Ki Hong

Thu, 20 Jun 2019 23:00:08 +0000

Innovative medical oncologist and revered mentor. He was born near Seoul, South Korea, on Aug 13, 1942, and died in Newport Beach, CA, USA, on Jan 2, 2019, aged 76 years.

[Perspectives] The case for desegregation

Thu, 20 Jun 2019 23:00:07 +0000

The year is 1960. The place is New Orleans, LA, USA. And it is the first day of school—a customary passage of childhood so routine, it is ordinary. But in the preceding 6 years, familiar days like these were punctuated by moments so unusual, the nation took note. This was one of the unusual days. Unlike the black girls and boys in her neighbourhood, who also ventured to new classrooms, Ruby Bridges arrived flanked by white men wearing official-looking suits and badges. Her photo was taken for the newspaper.

[Perspectives] Rebecca Katz: leading light in global health security

Thu, 20 Jun 2019 23:00:07 +0000

It may seem strange that the Global Health Security 2019 conference, in Sydney, NSW, Australia, on June 18–20, is the first of its kind, but as Rebecca Katz, Director of the Center for Global Health Science and Security at Georgetown University, Washington, DC, USA, explains: “The global health security field is actually relatively young, and while a lot of work has been going on in many parts of the world over the past decade or so, the Sydney meeting will be a unique opportunity to bring the key players together to help shape future priorities.”

[World Report] Trudeau signals support for Canadian pharmacare

Thu, 20 Jun 2019 23:00:07 +0000

Prime Minister Justin Trudeau makes strides towards pharmacare as access to medicines is likely to become a hot topic in the upcoming federal elections. Paul Webster reports.

[World Report] Head of Indian Affairs Foundation fired in Brazil

Thu, 20 Jun 2019 23:00:07 +0000

The move is the latest in a series of measures prioritising agriculture business over the health of Indigenous populations in the country. Barbara Fraser reports.

[World Report] India: health workers strike after attack on junior doctor

Thu, 20 Jun 2019 23:00:07 +0000

Attacks come as medical bodies across India call for strenghtened legislation to protect health-care workers who are targeted by aggrieved family members. Dinesh C Sharma reports

[World Report] Ebola outbreak not a PHEIC, says WHO

Thu, 20 Jun 2019 23:00:07 +0000

WHO's expert panel's decision came as a surprise to many global health experts, as some worry insufficient funding threatens the response. John Zarocostas reports.

[Comment] Offline: Prescriptions for an Age of Apprehension

Thu, 20 Jun 2019 23:00:07 +0000

The Lancet was founded (in 1823) at a strange historical moment. Among progressive politicians and intellectuals, there was acute disappointment that the Enlightenment had seemingly delivered only grinding destitution, workhouses for the poor, and crowded debtors' prisons. But, paradoxically, there was optimism too—a growing movement for social and political reform. A spirit of human sympathy and feeling was emerging. The Romantic movement, exemplified by William Blake's crusade for imaginative redemption from the “heaven of our misery”, was revitalising the hopes of (and for) society.

[Comment] Blockchain in health care: hype, trust, and digital health

Thu, 20 Jun 2019 23:00:07 +0000

The promise of digital health care continues to be enthusiastically promoted but has been difficult to realise. Evidence-based practice, along with patient safety assurances, information governance, and certification, does not fit easily with schemes to accelerate innovation. Trust in the efficacy and safety of new models of care, such as that potentially delivered by artificial intelligence (AI), remains uncertain. Blockchain technology might contribute to overcoming these problems by enabling greater openness, transparency, and trust.

[Comment] Gentamicin as an alternative treatment for gonorrhoea

Thu, 20 Jun 2019 23:00:07 +0000

A high gonorrhoea disease burden, increasing rates, and growing antimicrobial resistance portend a developing global public health crisis.1 Gonorrhoea can cause reproductive complications such as pelvic inflammatory disease and infertility, blindness in infants born to infected mothers, and can facilitate HIV acquisition and transmission. Effective treatment prevents sequelae and transmission. Yet Neisseria gonorrhoeae has developed resistance to each antimicrobial used for treatment.2 Development of new antimicrobials has not kept pace.

[Comment] Are drug-eluting stents safer than bare-metal stents?

Thu, 20 Jun 2019 23:00:07 +0000

Percutaneous coronary intervention with implantation of drug-eluting stents (DES) has reduced the need for repeat revascularisation compared with bare-metal stents (BMS).1 However, first-generation DES with durable polymers were associated with a slightly increased risk of stent thrombosis, especially very late stent thrombosis after discontinuation of dual antiplatelet therapy.2,3 New-generation DES have therefore been developed to improve safety.

[Comment] Increases in alcohol consumption in middle-income countries will lead to increased harms

Thu, 20 Jun 2019 23:00:07 +0000

The WHO Global Monitoring Framework for Non-Communicable Diseases includes an ambitious global target of a 10% reduction in the harmful use of alcohol by 2025.1 A modelling study by Jakob Manthey and colleagues2 in The Lancet indicates that this goal will not be met, with a plateau in consumption in high-income countries offset by marked projected increases in middle-income countries.

[Editorial] Gross negligence manslaughter

Thu, 20 Jun 2019 23:00:07 +0000

An independent review of gross negligence manslaughter (GNM) and culpable homicide, published on June 6, describes how the conduct of the General Medical Council (GMC) relating to the case of Hadiza Bawa-Garba severely damaged its relationship with the doctors it is supposed to regulate. The review acknowledges several serious concerns about the GMC that emerged from this, and other similar, recent cases. These concerns include an over-representation of black and ethnic minority doctors referred to the GMC and a potential conflict in the responsibilities of the GMC both to ensure doctors are safe to practise and to maintain public confidence in the profession.

[Editorial] The politics of PHEIC

Thu, 20 Jun 2019 23:00:07 +0000

An emergency committee decided on June 14 that the current Ebola virus disease outbreak in the Democratic Republic of the Congo did not warrant a Public Health Emergency of International Concern (PHEIC). It was the third time the committee has decided against a PHEIC declaration since this Ebola outbreak began in August, 2018, which has now affected over 2100 people. WHO Director-General Tedros Adhanom Ghebreyesus agreed with the committee's advice but asserted the outbreak remains an emergency.

[Editorial] Stonewall: 50 years of fighting for their lives

Thu, 20 Jun 2019 23:00:07 +0000

A single image survives of the early morning hours of June 28, 1969. The grainy black and white photograph is a juxtaposition: a macramé vest, eyes wide, the sheen of sweat on young faces, the officers' crisp uniforms, the glint of service cap visors. In front of the mismatched brick arches of the Stonewall Inn, immortalised, a throng pushing against authority and pushing forward lesbian, gay, bisexual, and transgender (LGBT) liberation.

Northeast Congo Insecurity Hampers Response to Measles Outbreak

Thu, 20 Jun 2019 17:15:17 +0000

Insecurity in northeast Congo has hampered a measles vaccination drive and forced people to flee their homes, local responders said on Wednesday, complicating efforts to control the spread of a virus that has killed more people that Ebola this year.
Reuters Health Information

Biologics in IBD: More Thoughtful Use Could Improve Outcomes

Thu, 20 Jun 2019 16:52:41 +0000

The marketplace introduction of infliximab for the treatment of IBD did not reduce hospitalization or surgery rates in a large population of patients with Crohn disease and ulcerative colitis.
Medscape Medical News

Women Have More Sleep Problems, Brazilian Researchers Find

Thu, 20 Jun 2019 16:05:18 +0000

More women than men have trouble sleeping, and people of both sexes with insomnia have a lower perception of quality of life, according to a study done in Sao Paulo, Brazil.
Reuters Health Information

Interleukin-17 Edges TNF Inhibitor in Psoriatic Arthritis

Thu, 20 Jun 2019 15:12:24 +0000

Early outcomes for the combined end point of skin clearance and disease activity in a comparison of biologics can give physicians confidence in the IL-17 inhibitor, SPIRIT-H2H investigators say.
Medscape Medical News

Four Strategies Facilitate Hospital Admission of Acutely Ill Older Adults

Thu, 20 Jun 2019 14:27:25 +0000

Four geriatric-evaluation and -management strategies ("GEMS") can help hospitalists routinely and efficiently assess acutely ill older adults.
Reuters Health Information

Top Physicians List Sees Name Change, New Faces

Thu, 20 Jun 2019 14:08:01 +0000

Former FDA chief Gottlieb remains at number one. The new list includes more women at the top, and 10 new names in the top 15.
Medscape Medical News

RXQ Compounding Recalls All 'Sterile' Product

Thu, 20 Jun 2019 14:22:29 +0000

Sterility concerns prompt RXQ Compounding to recall all unexpired sterile products, including injectable bevacizumab, epinephrine, ketamine, fentanyl, and midazolam, among others.
News Alerts

H pylori Raises Phosphate Binder Pill Burden in Dialysis

Thu, 20 Jun 2019 14:38:07 +0000

If those with Helicobacter pylori don't take a proton pump inhibitor or sodium bicarbonate, they have a higher phosphate binder pill burden, researchers report, between six and nine tablets a day.
Medscape Medical News

Expected Shortage of TB Tests Prompts New CDC Recommendations

Thu, 20 Jun 2019 14:49:47 +0000

The CDC has issued new skin testing recommendations in response to the anticipated nationwide shortage of the Aplisol tuberculin skin test.
Medscape Medical News

Anti-TNF Therapy for IBD Can Be Safely Stopped Before Third Trimester

Thu, 20 Jun 2019 12:58:56 +0000

Anti-tumor necrosis factor (TNF) therapy in pregnant women with inflammatory bowel disease (IBD) can be discontinued before week 30 of gestation without increasing relapse risk or harming the fetus, researchers report.
Reuters Health Information

Tanezumab Eases Severe Osteoarthritis Pain

Thu, 20 Jun 2019 13:23:10 +0000

The monoclonal antibody is a new opioid-sparing strategy in osteoarthritis, delegates heard at the European League Against Rheumatism 2019 Congress, but some cases of joint destruction remain.
Medscape Medical News

'Bureaucratic' Medicaid Work Rules Linked to Coverage Losses

Thu, 20 Jun 2019 13:48:18 +0000

New Arkansas Medicaid work requirements did not make a significant difference in employment rates but were linked to a rise in the uninsured population, a study found.
Medscape Medical News

В России может появиться дополнительная система отчетности наркотических анальгетиков

Thu, 20 Jun 2019 18:42:30 +0000

Просьба декриминализировать ответственность медиков по статье о наркотиках, прозвучавшая на Прямой линии с президентом, может обернуться дополнительными проблемами для врачей. По мнению главы государства, к изменению законодательства следует подходить с осторожностью. А для решения этого вопроса надо выработать систему отчетности и фиксации оборота сильнодействующих препаратов.

Cholecystectomy Linked to Lower Stroke Risk in Gallstone Disease

Thu, 20 Jun 2019 12:11:12 +0000

Cholecystectomy is associated with a reduced risk of stroke, according to a new retrospective cohort study.
Reuters Health Information

New Recommendations Aim to Protect Electronic Communication of Pediatric Health Records

Thu, 20 Jun 2019 12:14:24 +0000

A new policy statement from the American Academy of Pediatrics (AAP) offers several recommendations intended to safeguard the communication of pediatric electronic health records (EHR) with patients and their guardians.
Reuters Health Information

Refugees Have High Burden of Mental Health Problems

Thu, 20 Jun 2019 12:51:46 +0000

Refugees and asylum seekers fleeing conflict in their homeland often have high levels of psychological distress and should undergo routine mental health screening at arrival to a new country, researchers said at the North American Refugee Health Conference held June 14 to 16 in Toronto, Canada.
Reuters Health Information

One in Five Surgeons Still Using Low-Value Arteriovenous Graft for Dialysis Access

Thu, 20 Jun 2019 12:30:58 +0000

One in five surgeons who do hemodialysis access procedures continue to use arteriovenous grafts (AVG) instead of the recommended best practice of arteriovenous fistula (AVF), researchers say.
Reuters Health Information

Strobing Stage Lights Could Up Risk of Epileptic Seizures

Thu, 20 Jun 2019 12:25:30 +0000

Flashing light effects that have become the norm for electronic dance music concerts could bring on epileptic seizures in young people who may not know they have a vulnerability, Dutch researchers say.
Reuters Health Information

Lymphoma Control Better Goal Than Remission

Thu, 20 Jun 2019 11:41:48 +0000

Drugs used to treat lymphoplasmacytic lymphoma can have adverse effects, so lowering therapeutic targets might help, delegates heard at the International Waldenstrom's Macroglobulinemia Forum.
Medscape Medical News

Работать полезно для психического здоровья. Но одного дня в неделю достаточно

Thu, 20 Jun 2019 17:17:36 +0000

Исследование, опубликованное в журнале Social Science and Medicine, показывает, что, когда люди устраиваются на оплачиваемую работу по восемь часов или меньше в неделю, риск возникновения проблем с психическим здоровьем снижается в среднем на 30 %.

Отправляясь в путешествие по России, не забудьте полис ОМС

Thu, 20 Jun 2019 17:47:28 +0000

Полис ОМС действует на всей территории РФ, вне зависимости от того, где он был оформлен. Страховые медицинские организации, работающие в системе ОМС и входящие во Всероссийский союз страховщиков (ВСС), подготовили памятку для россиян, собирающихся в командировку или отпуск в другой регион страны.

US Suicide Rates Hit Record-High Levels, CDC Says

Thu, 20 Jun 2019 10:46:39 +0000

Suicide rates are up 33% since 1999, with increases seen in both men and women and in most races and ethnicities.
Medscape Medical News

A Journey Into Cancerland

Thu, 20 Jun 2019 07:31:08 +0000

In "Cancerland: A Medical Memoir," David Scadden, MD, chronicles a journey to a foreign land populated by strange ideas, customs, and people.
Medscape Medical News

Исследование продемонстрировало кризис доверия к вакцинации в Европе

Thu, 20 Jun 2019 08:53:11 +0000

Глобальное исследование отношения людей к науке выявило масштабы кризиса доверия к вакцинам в Европе. Оно показало, что только 59% людей в Западной Европе и 50% в Восточной Европе считают вакцины безопасными. Средний показатель доверия вакцинам во всем мире – 79%.

FDA Panel Deluged With Conflicting Paclitaxel-Device Data in PAD

Wed, 19 Jun 2019 21:16:22 +0000

Hospitals have pulled the devices off the shelves as a result of an excess mortality signal that remains without a clear explanation.
Medscape Medical News

Cognitive Decline May Accelerate After Ischemic Events

Wed, 19 Jun 2019 17:27:05 +0000

Adults after incident CHD events were at higher risk for long-term cognitive decline compared with CHD-free individuals.
Medscape Medical News

Well-Controlled Epilepsy Also Tied to Sudden Death

Wed, 19 Jun 2019 16:00:23 +0000

Although the risk is low, new research suggests sudden unexpected death can happen to anyone with epilepsy, even patients whose epilepsy is well controlled.
Medscape Medical News

Pneumococcal Conjugate Vaccine in Infancy Cuts Otitis Media

Wed, 19 Jun 2019 15:06:55 +0000

Administration of pneumococcal conjugate vaccine (PCV) in early infancy substantially reduces the risk of pneumococcal acute otitis media (AOM), according to a new Cochrane review.
Reuters Health Information

California Vaccine Bill Amended to Appease Governor

Wed, 19 Jun 2019 14:57:58 +0000

The vaccine bill was amended to broaden the eligibility for children's medical exemptions from vaccines — and narrow the circumstances under which public health officials would review those exemptions.
Kaiser Health News

Never Say 'Die': Why So Many Doctors Won't Break Bad News

Wed, 19 Jun 2019 15:04:02 +0000

It's never easy to tell a patient about a terminal illness, but a longtime doctor whose own diagnosis was botched says physicians must do better.
Kaiser Health News

Spin in Health News Affects Patients' Views on Treatments

Wed, 19 Jun 2019 15:12:13 +0000

When health news stories misrepresent study findings, patients and caregivers are more likely to view the treatments as beneficial, a recent study suggests.
Medscape Medical News

Hepatitis C Antiviral Treatment Linked to Parkinson's

Wed, 19 Jun 2019 15:22:54 +0000

A new study reports that hepatitis C patients treated with antiviral medication were less likely to develop Parkinson's disease compared with those not receiving such therapy.
Medscape Medical News

Is Medicare Shared Savings Plan Working? Researchers at Odds

Wed, 19 Jun 2019 14:05:18 +0000

Researchers found the exits of high-spending doctors and their patients overestimated the savings from accountable care organizations. Another research team questions their methodology and conclusions.
Medscape Medical News

Регулярное употребление йогурта снижает риск появления предраковых образований в кишечнике

Wed, 19 Jun 2019 18:15:07 +0000

Две и более 245-граммовых порции йогурта в неделю способствуют снижению риска развития аномальных разрастаний (аденом) – предвестников рака кишечника. Особенно это касается аденом, которые с высокой вероятностью могут стать злокачественными, и для тех, которые расположены в толстой кишке.

Physical Un-Fitness Linked With Depression, Anxiety in Middle-Aged Women

Wed, 19 Jun 2019 12:20:37 +0000

Mid-life women with weak upper and lower body fitness may be more prone to depression and anxiety, a study from Singapore suggests.
Reuters Health Information

Texas Is Latest State to Attack Surprise Medical Bills

Wed, 19 Jun 2019 12:31:59 +0000

A new state law says hospitals and insurers will have to work it out among themselves when they can't agree on a price — instead of sending huge bills to patients.
Kaiser Health News

Medicaid Expansion Tied to Lower Rates of Child Neglect, but Not Abuse

Wed, 19 Jun 2019 12:34:46 +0000

New research shows Medicaid expansion under the Affordable Care Act improved children's health but left rates of abuse unchanged.
Medscape Medical News

Регулярное употребление йогурта снижает риск появления предраковых образований в кишечнике

Wed, 19 Jun 2019 18:15:07 +0000

Две и более 245-тиграммовых порции йогурта в неделю способствуют снижению риска развития аномальных разрастаний (аденом) – предвестников рака кишечника. Особенно это касается аденом, которые с высокой вероятностью могут стать злокачественными, и для тех, которые расположены в толстой кишке.

U.S. Teen Suicides Rising, Especially Among Boys

Wed, 19 Jun 2019 11:02:29 +0000

For nearly a decade, suicide rates have been climbing among U.S. teens, with an especially pronounced increase in boys recently, a new study suggests.
Reuters Health Information

Surgeons With Conduct Reports From Peers Put Patients at Risk

Wed, 19 Jun 2019 11:00:36 +0000

The percentages of patients who had medical or surgical complications rose with the number of peer reports of surgeons' unprofessional behavior, a study found.
Medscape Medical News

Борщевик. Что нужно знать об этом опасном растении и фотохимическом дерматите

Wed, 19 Jun 2019 17:46:45 +0000

В соке борщевика содержатся потенциально токсичные вещества (фуранокумарины), которые резко повышают чувствительность кожи к УФ-излучению. Поэтому при попадании сока на кожу возникают фотохимические дерматиты, по глубине аналогичные термическим одогам I-II-IIIА степени. Они появляются не сразу, а через несколько часов или дней. Само прикосновение к растению безболезненно.

New Guidelines Carve Path for Probiotics in Gastroenterology

Wed, 19 Jun 2019 10:07:36 +0000

The American Gastroenterological Association is, for the first time, backing live biotherapeutics for three indications, even though evidence is scant, while research momentum builds in these areas.
Medscape Medical News

CARMELINA: Linagliptin Safe in Diabetes Across Age, Renal Groups

Wed, 19 Jun 2019 10:21:55 +0000

Linagliptin demonstrated "reassuring" cardiovascular and renal safety in patients with type 2 diabetes, even among those who were older or had severe chronic kidney disease, researchers report.
Medscape Medical News

Novel Drug Targets Lymphoma Cells' 'Don't Eat Me' Signal

Wed, 19 Jun 2019 10:27:39 +0000

The first-in-class agent Hu5F9 is a macrophage immune checkpoint inhibitor and, when added onto rituximab, shows potentially long-lasting efficacy in patients with relapsed and refractory lymphoma.
Medscape Medical News

MABs Successfully Treat Immunotherapy-Related Myocarditis

Wed, 19 Jun 2019 10:34:03 +0000

Alemtuzumab and abatacept were both successfully used in patients with steroid-refractory myocarditis that developed during treatment with immune checkpoint inhibitors.
Medscape Medical News

In Combating Surprise Bills, Lawmakers Miss Air Ambulance Costs

Wed, 19 Jun 2019 10:46:58 +0000

The median cost of an air ambulance bill is more than $36,000 and seldom covered by insurance. Yet none of the proposals in Congress to fix surprise medical bills address these services.
Kaiser Health News

Mail-Order Medicine: Prescribe With Caution

Wed, 19 Jun 2019 07:21:12 +0000

A California physician surrendered his license after prescribing drugs with only the patient information from an online questionnaire, and there are still 'unanswered questions' about regulation.
Medscape Medical News

Чем больше курит отец во время беременности, тем выше риск астмы у ребенка

Wed, 19 Jun 2019 13:36:50 +0000

Дети курящих отцов, которые подвергаются воздействию табачного дыма , находясь еще в утробе, имеют более высокий риск развития бронхиальной астмы, чем те, кто не сталкивался с этим фактором риска. По данным исследования, наибольшая вероятность развития астмы у таких детей к возрасту шести лет.

U.S. Measles Cases Hit 1044 This Year

Tue, 18 Jun 2019 16:06:18 +0000

The United States recorded 22 new measles cases last week, a 2.2% increase, taking the total cases for the year to 1,044 in the worst outbreak since 1992, federal health officials said on Monday.
Reuters Health Information

VBI Hepatitis B Vaccine Meets Main Goals in Late-Stage Trial

Tue, 18 Jun 2019 16:12:02 +0000

VBI Vaccines Inc said on Monday a late-stage study testing its hepatitis B vaccine against GlaxoSmithKline's Engerix-B in adults met its main goals.
Reuters Health Information

3D Printing Can Help Guide Urological Surgeries

Tue, 18 Jun 2019 16:23:52 +0000

Prior to urological surgery, 3-dimensional printing can help guide the identification of lesions and their relationships with surrounding structures, among other uses, researchers report.
Reuters Health Information

Genetics Research Gets Help From Social Media

Tue, 18 Jun 2019 17:07:24 +0000

Researchers have harnessed the power of social media to build a genetic database, according to a new report.
Reuters Health Information

FDA Issues Class I Recall of Advance Enforcer PTA Balloon Catheters

Tue, 18 Jun 2019 18:30:05 +0000

The manufacturer has received multiple complaints about the balloon catheters bursting below the rated burst pressure, which could cause serious injury or death.
News Alerts

Cannabis Use During Pregnancy Rising, but Likely Unsafe

Tue, 18 Jun 2019 16:53:59 +0000

Although prenatal cannabis use was linked to risk of several poor perinatal and neonatal outcomes, the findings must be considered alongside the values brought to their interpretation, experts say.
Medscape Medical News

Overactive Innate Immunity Tied to Higher Stroke Risk

Tue, 18 Jun 2019 16:54:05 +0000

A prospective cohort study of nearly 8000 people who were followed for 8 years identified components of the immune system that either increase or decrease stroke risk.
Medscape Medical News

Sodium Bicarbonate Slows Chronic Kidney Disease Safely

Tue, 18 Jun 2019 16:55:14 +0000

Prognosis improves when metabolic acidosis in patients with kidney disease is treated with sodium bicarbonate, new data show, and therapy does not add to fluid overload or uncontrolled blood pressure.
Medscape Medical News

Osteoporosis Drugs May Help Oldest, Sickest Women Most

Tue, 18 Jun 2019 17:02:11 +0000

Osteoporosis drugs appear to help women older than 80 years with multiple morbidities and osteoporosis; very elderly women with high fracture risk but no osteoporosis may benefit less, a study found.
Medscape Medical News

CMS Proposes Online Option for Part D Prior Authorization

Tue, 18 Jun 2019 17:37:59 +0000

Medicare officials are seeking to update a Part D prior authorization process that long has relied on phone calls and faxes.
Medscape Medical News

Lack of Sleep Harms College Students' Mental Health

Tue, 18 Jun 2019 16:16:24 +0000

College students who don't get enough sleep are at increased risk of developing mental health problems, including anxiety and suicidal thoughts.
Medscape Medical News

PA Cardiologist Convicted in $13 Million Billing Scheme

Tue, 18 Jun 2019 16:31:13 +0000

The federal conviction stemmed from fraudulent insurance billings for an angina treatment the physician advertised as the 'Fountain of Youth.'
Medscape Medical News

Untreated White-Coat Hypertension Tied to CV Events, Mortality

Tue, 18 Jun 2019 15:11:13 +0000

New data support the 'critical' role of out-of-office blood pressure monitoring for the diagnosis and management of hypertension, researchers say.
Medscape Medical News

Nerve Stimulator Showing Promise in Rheumatoid Arthritis

Tue, 18 Jun 2019 15:38:14 +0000

Once-daily stimulation of the vagus nerve with an app-controlled implanted microregulator helped patients with refractory rheumatoid arthritis in a small pilot study, researchers report.
Medscape Medical News

New Statement on 'Time in Range' Targets for CGM Use in Diabetes

Tue, 18 Jun 2019 14:03:08 +0000

Guidelines address CGM goals for type 1 and type 2 diabetes, older/high-risk patients, and pregnant women with diabetes.
Medscape Medical News

PTSD: Psychotherapy Bests Drugs Alone Over the Long-Term

Tue, 18 Jun 2019 14:16:30 +0000

Results of a new meta-analysis confirm recommendations for psychotherapy as a first-line therapy for posttraumatic stress disorder.
Medscape Medical News

Occupational Illnesses Major, Under-reported Problem

Tue, 18 Jun 2019 14:17:46 +0000

Workers can be reluctant to come forward about health hazards on the job and physicians say reporting is burdensome.
Medscape Medical News

Инфаркт и стенокардия говорят о риске нарушения мышления в скором будущем

Tue, 18 Jun 2019 20:37:20 +0000

По данным нового исследования, пациенты, которым поставлен диагноз ишемической болезни сердца, подвергаются повышенному риску снижения когнитивных функций. Исследование, опубликованное в Journal of the American College of Cardiology, показало, что оценки по когнитивным тестам, включая вербальную память и ориентацию во времени.

Nurse at Cancer Center Accused of Replacing Opioids With Water

Tue, 18 Jun 2019 12:49:51 +0000

At a National Cancer Institute-designated cancer center, a registered nurse allegedly stole opioids and covered up the theft by refilling the depleted syringes with water.
Medscape Medical News

Only 1 Year of Tx: Venetoclax/Obinutuzumab Combo in CLL

Tue, 18 Jun 2019 13:03:29 +0000

The combination has the benefit of a fixed-duration course of just 12 months compared to other treatment options that are taken for longer, or even indefinitely.
Medscape Medical News

QOL With Ambulatory Advanced Heart Failure Worse for Women Than Men

Tue, 18 Jun 2019 12:24:56 +0000

Quality of life in patients with ambulatory advanced heart failure is worse among women than among men, according to findings.
Reuters Health Information

New Lymphocyte Type Plays Important Role in Type 1 Diabetes

Tue, 18 Jun 2019 12:20:54 +0000

A newly identified lymphocyte that expresses both T-cell receptors (TCR) and B-cell receptors (BCR) appears to play an important role in type 1 diabetes, researchers report.
Reuters Health Information

Эксперты обсудили готовность фармотрасли к маркировке лекарств и ее влияние на себестоимость

Tue, 18 Jun 2019 17:44:29 +0000

Подготовка к работе в системе маркировки лекарств вышла на финишную прямую. Через шесть с половиной месяцев эксперимент по добровольной маркировке превратится в обязательное требование для всех участников фармрынка на территории России. Работа в системе маркировки будет являться лицензионным требованием.

Boston Children's Hospital Still Number One, US News Says

Tue, 18 Jun 2019 11:28:58 +0000

For the sixth year in a row, Boston Children's Hospital is the number 1 pediatric hospital, with Children's Hospital of Philadelphia taking the number 2 spot on the list of best pediatric hospitals.
Medscape Medical News

Эксперты обсудили готовность фармотрасли к маркировке лекарств и ее влияние на себестоимость

Tue, 18 Jun 2019 17:44:29 +0000

Подготовка к работе в системе маркировки лекарств вышла на финишную прямую. Через шесть с половиной месяцев эксперимент по добровольной маркировке превратится в обязательное требование для всех фармпроизводителей и дистрибьюторов на территории России. Работа в системе маркировки будет являться лицензионным требованием.

Novel Agent Shows Promise as First Possible Therapy for Achondroplasia

Tue, 18 Jun 2019 10:14:29 +0000

A dose finding and extension study demonstrates the safety and efficacy of vosoritide, a recombinant C-type natriuretic peptide analogue, in a proof of concept trial in children with achondroplasia.
Medscape Medical News

BP Reduction May Have Positive Effects in Alzheimer's

Tue, 18 Jun 2019 10:38:55 +0000

Antihypertensive treatment was not only safe in patients with Alzheimer's disease, but blood flow in the hippocampus actually increased, a substudy of the NILVAD trial suggests.
Medscape Medical News

Guidance Highlights Dangers of Measles in Pregnancy

Tue, 18 Jun 2019 08:06:42 +0000

A revised consensus statement and a new practice advisory provide guidance for clinicians caring for pregnant and reproductive-aged women who are at high risk of developing measles.
Medscape Medical News

FDA OKs Liraglutide for Use in Youth With Type 2 Diabetes

Tue, 18 Jun 2019 07:16:13 +0000

Liraglutide is the first noninsulin agent approved to treat pediatric type 2 diabetes in nearly 20 years; approval comes at a time when doctors are increasingly concerned about type 2 diabetes in kids.
FDA Approvals

Ученые: Два часа наслаждения природой в неделю - необходимый для здоровья минимум

Thu, 13 Jun 2019 20:45:36 +0000

Британские ученые высчитали, сколько времени нужно проводить на природе, чтобы это действительно положительно отразилось на здоровье: два часа в неделю. Авторы отмечают, что для получения пользы не требуется ничего дополнительного, можно просто любоваться видом. Научная работа была опубликована в журнале Scientific Reports.

Ревматические болезни оказались не помехой для вакцинации

Tue, 18 Jun 2019 10:59:51 +0000

Ревматические заболевания не помеха для вакцинации, согласно исследованиям, представленным в Мадриде на Ежегодном Европейском конгрессе ревматологов, организованном совместно с Обществом детской ревматологии.

CGM During Type 1 Diabetes Pregnancy Makes Substantial Cost Savings Over Fingerprick Testing

Tue, 18 Jun 2019 01:29:02 +0000

Care of pregnant mothers with type 1 diabetes and their newborns costs significantly less with use of continuous glucose monitoring than with conventional fingerprick testing, UK researchers said.
Medscape News UK

Just Because TAVR Can Be Done in ESRD, Should It Be Offered?

Mon, 17 Jun 2019 18:23:48 +0000

One of the largest studies to date suggests procedural outcomes appear acceptable but cannot answer which subset of patients would benefit most.
Medscape Medical News

Better to Stay Up Late Than Turn In Early?

Mon, 17 Jun 2019 18:28:23 +0000

In young individuals who have shortened sleep, staying up late may be better than getting up early, new research suggests.
Medscape Medical News

U.S. Drugmakers File Lawsuit Against Rule Requiring Drug Prices in TV Ads

Mon, 17 Jun 2019 16:57:48 +0000

U.S. drugmakers on Friday filed a lawsuit to prevent the companies from disclosing the list price of prescription drugs in direct-to-consumer television advertisements as per a newly proposed government regulation.
Reuters Health Information

Cortical Stimulation Accurately Guides Epilepsy Surgery

Mon, 17 Jun 2019 16:55:00 +0000

Inducing seizures with cortical stimulation accurately identifies the target area for resection and significantly reduces hospital stays, a new study shows.
Medscape Medical News

'Hysterical' Motor Symptoms Explained?

Mon, 17 Jun 2019 16:56:25 +0000

Abnormally high levels of limbic glutamate may be at the root of unexplained functional motor symptoms that previously have been attributed to 'hysteria.'
Medscape Medical News

Necrotizing Infections Rise With Warming Oceans, Study Shows

Mon, 17 Jun 2019 17:18:15 +0000

A recent case study shows that rising water temperatures are causing serious Vibrio infections to emerge in areas once considered too cool to support the bacterium.
Medscape Medical News

Researchers Find Way to Convert Type A Blood to Type O

Mon, 17 Jun 2019 17:40:47 +0000

Researchers found a way to use gut enzymes to convert type A blood to the universal donor type O blood, possibly paving the way for increasing the supply of type O blood.
Medscape Medical News

CREDENCE 'Knocks Your Socks Off'; New Analysis Reported at ADA

Mon, 17 Jun 2019 17:41:30 +0000

Latest analysis of CREDENCE with SGLT2 inhibitor canagliflozin shows the agent has a cardio- and renal-protective effect in both primary and secondary CV prevention populations.
Medscape Medical News

WHO Panel Decides Not to Declare International Ebola Emergency

Mon, 17 Jun 2019 16:49:24 +0000

A World Health Organization panel decided on Friday not to declare an international emergency over Congo's Ebola outbreak despite its spread to Uganda this week, concluding such a declaration could cause too much economic harm.
Reuters Health Information

Women as Likely to Get HIV on DMPA as Other Contraceptives

Mon, 17 Jun 2019 14:52:02 +0000

After 30 years, physicians can finally speak with confidence to women about long-acting contraception and HIV risk.
Medscape Medical News

Circadian Rhythm Disturbances May Be an Alzheimer's Marker

Mon, 17 Jun 2019 15:44:49 +0000

Circadian rhythm disturbances in older adults may be markers of Alzheimer disease and its progression, new research suggests.
Medscape Medical News

Nasal Spray Flu Vaccine Safe for Children With Asthma

Mon, 17 Jun 2019 15:49:42 +0000

Children with asthma and recurrent wheezing can safely receive the nasal spray influenza vaccine, a large study found.
Medscape Medical News

Kids' Behavior Tied to Prenatal Exposure to Epilepsy Drugs

Mon, 17 Jun 2019 14:31:28 +0000

While almost a third of children exposed prenatally to valproate have clinically relevant problem behaviors at age 6 or 7 years, exposure to other drugs also increases the risk, new study found.
Medscape Medical News

Imaging Can Mislead in Inflammatory Arthritis

Mon, 17 Jun 2019 13:20:43 +0000

Tests can help clinicians assess patients with suspected inflammatory arthritis, but 'it shouldn't drive' treatment, an expert reminds rheumatologists.
Medscape Medical News

Novel Drug Could Be 'Disease Modifying' in Sickle Cell Disease

Mon, 17 Jun 2019 13:22:13 +0000

An investigational agent, the first-in-class drug voxelotor, is seen as potentially ‘disease-modifying' as it targets mechanisms that cause anemia.
Medscape Medical News

Daratumumab Boosts Outcomes in Newly Diagnosed Multiple Myeloma

Mon, 17 Jun 2019 13:25:13 +0000

The monoclonal antibody shows evidence of improving outcomes and is being proposed as offering a 'new standard of care' for patients newly diagnosed with the disease who are eligible for transplant.
Medscape Medical News

Diroximel Fumarate Shows Low GI Adverse Events in MS

Mon, 17 Jun 2019 10:06:04 +0000

The novel drug for relapsing multiple sclerosis is designed to reduce gastrointestinal events compared to dimethyl fumarate.
Medscape Medical News

CV Benefit of Newer Type 2 Diabetes Drugs Not Seen in Blacks

Mon, 17 Jun 2019 10:06:56 +0000

In cardiovascular outcomes trials for type 2 diabetes drugs, data weren't significant for benefit among the small number of black and African American participants.
Medscape Medical News

Ученые рассказали, насколько часто татуировки и пирсинг приводят к проблемам со здоровьем

Mon, 17 Jun 2019 15:55:07 +0000

Эксперты в области здравоохранения предупреждают, что татуировка или пирсинг повышает риск получить ожог или заразиться серьезной инфекцией из-за халатного отношения исполнителя и недостаточной гигиены в салонах.

Causal Effect of Lp(a) on CVD Not Modified by LDL

Mon, 17 Jun 2019 08:53:54 +0000

Lipoprotein(a) is a common and strong risk factor for CVD, and the relationship isn't modified by LDL levels, gender, or antiplatelet therapy, researchers report, setting the stage for future randomized trials.
Medscape Medical News

Цифровая медицина помогает использовать все возможности ОМС

Mon, 17 Jun 2019 15:22:31 +0000

Внедрение цифровых технологий в здравоохранение происходит стремительно. И вместе с растущим интересом граждан к своему здоровью это стимулирует появление разнообразных телемедицинских проектов для пациентов– от электронной регистратуры до тестирования на риск различных заболеваний.

Telehealth Abortion Proves Safe in US Test, Researchers Say

Mon, 17 Jun 2019 08:14:04 +0000

A TelAbortion approach can safely help women obtain medical abortions in states where the procedure is legal but have few clinics that provide the service, new data show.
Medscape Medical News

Recommendations to Reform USMLE Now Available for Comment

Mon, 17 Jun 2019 06:01:19 +0000

Preliminary recommendations on the "complex" issues related to USMLE score reporting are now available online for comment through July 26.
Medscape Medical News

Музыка может облегчить боль у раковых пациентов

Mon, 17 Jun 2019 12:10:45 +0000

Прослушивание музыки в домашних условиях может снизить боль и усталость у больных раком, ослабить такие симптомы, как потеря аппетита и трудности с концентрацией внимания, выяснили тайваньские ученые.

Ученые выявили почти 400 использующихся неэффективных методов лечения

Sat, 15 Jun 2019 15:45:39 +0000

Исследователи из Орегонского университета Здоровья и Науки, Медицинской школы Мэрилендского университета и Чикагского университета выявили почти 400 устоявшихся и использующихся медицинских практик, которые были признаны неэффективными в результате клинических исследований. Результаты они опубликовали в журнале открытого доступа eLife.

Ebola Not Known to Be Spreading in Uganda - WHO

Sat, 15 Jun 2019 04:56:53 +0000

There has been no known person-to-person spread of Ebola in Uganda despite the deaths of two people there who arrived with the disease from Congo, the top World Health Organization (WHO) expert told Reuters on Thursday.
Reuters Health Information

Communication Interventions May Alter Patients' DNR Decisions

Sat, 15 Jun 2019 05:37:21 +0000

Communication interventions such as pamphlets, discussions, videos about cardiopulmonary resuscitation (CPR), handouts about advanced directives and interviews by trained facilitators may alter patient decisions regarding do-not-resuscitate (DNR) orders, researchers say.
Reuters Health Information

Father's Smoking During Pregnancy Tied to Asthma in Kids

Sat, 15 Jun 2019 05:43:23 +0000

Children who are exposed to tobacco smoke from their fathers while they're in the womb may be more likely than those who are not to develop asthma by age 6, according to a study of chemical changes to DNA.
Reuters Health Information

Many Epinephrine Self-injectors Still Potent Long After Expiration Date

Sat, 15 Jun 2019 04:14:09 +0000

EpiPens and other autoinjectors filled with epinephrine to treat severe allergic reactions may still be potent enough to work many months past their labeled expiration date, according to a new study that concludes patients might need expensive refills less often.
Reuters Health Information

Orofacial Clefts Linked to Worse Neurodevelopmental, Academic Outcomes

Sat, 15 Jun 2019 03:48:09 +0000

Children with orofacial clefts (OFCs) have worse neurodevelopmental and academic outcomes than their peers, from infancy through adolescence, according to a new systematic review.
Reuters Health Information

Novel Assay Identifies Patients at High Risk for Kidney Injury

Fri, 14 Jun 2019 17:24:32 +0000

A urinary biomarker identifies patients at high risk for acute kidney injury after cardiac surgery, but that risk can be reversed with ischemic conditioning, researchers report.
Medscape Medical News

Michigan Doc Accused of Using Dirty Devices; HIV, Hepatitis Risk

Fri, 14 Jun 2019 17:25:10 +0000

The Michigan Licensing Department filed a formal complaint against Dr Roger Beyer for allegedly telling staff to re-use anorectal manometers on multiple patients.
Medscape Medical News

Harmful Chemicals in Children's Products

Fri, 14 Jun 2019 16:00:57 +0000

The chemicals children come in contact with each day can injure them, yet little is known about the ingredients in consumer products. Investigators have started tracking some common irritants.
Medscape Medical News

Biosimilars Gaining in Popularity for Rheumatoid Arthritis

Fri, 14 Jun 2019 16:18:36 +0000

Support for biosimilars, considered to be safe and effective, is accumulating and will likely continue because of costs, delegates heard at the European League Against Rheumatism Congress.
Medscape Medical News

Depression Called a 'Core Symptom' of MS

Fri, 14 Jun 2019 16:21:52 +0000

MRI studies show multiple sclerosis brain changes linked to depression, but randomized controlled trials of antidepressants in this population are lacking.
Medscape Medical News

New AHA/HFSA Statement on Diabetes and Heart Failure

Fri, 14 Jun 2019 16:30:07 +0000

A new scientific statement outlines guidance on managing concomitant heart failure and diabetes, common conditions that often occur together.
Medscape Medical News

AMA Backs Extending Medicaid to 12 Months After Childbirth

Fri, 14 Jun 2019 16:40:39 +0000

Current policy only covers women to 60 days postpartum, but the Centers for Disease Control and Prevention say one in three pregnancy-related deaths occur between a week and 1 full year after birth.
Medscape Medical News

Leuprorelin Depot Handling Errors Prompt EMA Review

Fri, 14 Jun 2019 16:47:00 +0000

Handling errors with leuprolide acetate depot formulations have reportedly led to problems such as leakages from the syringe or failure to deliver implants from the applicator, the EMA says.
News Alerts

ORACLE-MS: Cladribine Effective in MS Subgroups

Fri, 14 Jun 2019 14:05:15 +0000

The recently approved disease-modifying therapy is expected to find a niche for patients with multiple sclerosis who fail other agents.
Medscape Medical News

GSK Signs Up Gene-Editing Pioneers in Drug Discovery Alliance

Fri, 14 Jun 2019 13:31:48 +0000

British drugmaker GSK said it has struck a research deal with the early pioneers of a prominent gene-editing technology at the University of California, in a boost to its prospects for developing new drugs.
Reuters Health Information

Mini-Biographies Help Clinicians Connect With Patients

Fri, 14 Jun 2019 12:01:01 +0000

The "My Life, My Story" project has writers crafting a story of a patient's life to be included in the EHR. The idea came from a resident doing a rotation at a Wisconsin VA hospital in 2012.
Kaiser Health News

Measurable Residual Disease in AML Ups Post-HSCT Relapse Risk

Fri, 14 Jun 2019 12:53:33 +0000

Measurable residual disease, detected with next-generation genomic sequencing, is associated with a significantly increased risk for relapse. Experts question the prognostic ability of other assessment tools.
Medscape Medical News

Избыток веса и лишний жир оказались причиной многих болезней сердца и сосудов

Fri, 14 Jun 2019 18:15:22 +0000

Лишний вес и жировая масса являются прямой причиной болезней сердца и сосудов: стеноза аортального клапана, тромбоза глубоких вен, сердечной недостаточности и многих других. Новое исследование опубликовано в European Heart Journal.

Parkinson's Cost Burden Pegged at $50 Billion a Year

Fri, 14 Jun 2019 09:42:31 +0000

The new cost estimates, which include detailed caregiving costs, are double what had previously been reported.
Medscape Medical News

'ZIP-Code Risk' in Healthcare Needs Attention, Experts Say

Fri, 14 Jun 2019 07:55:49 +0000

Physicians and policy experts call for action on social determinants that can affect people's health, such as lacking money for medicine, food, and transportation.
Medscape Medical News

Prediction Model Helps Flag Sound-Alike, Look-Alike Drugs

Fri, 14 Jun 2019 07:08:11 +0000

As many as 250,000 hospitalizations occur each year as a result of errors involving a drug being confused with another, say Harvard researchers who developed the model.
Medscape Medical News

«Я простой хирург»: живая легенда мировой колопроктологии о себе и своей работе

Fri, 14 Jun 2019 09:09:17 +0000

В начале июня отметила свой десятилетний юбилей «Российская школа колоректальной хирургии». В масштабном научном форуме принял участие самый титулованный британский колопроктолог, который разработал и внедрил по всему миру принципиально новую методику оперативного лечения рака прямой кишки Билл Хилд. Патриарх мировой колопроктологии дал Медновостям небольшое интервью.

[Series] Gender norms and health: insights from global survey data

Thu, 13 Jun 2019 23:00:08 +0000

Despite global commitments to achieving gender equality and improving health and wellbeing for all, quantitative data and methods to precisely estimate the effect of gender norms on health inequities are underdeveloped. Nonetheless, existing global, national, and subnational data provide some key opportunities for testing associations between gender norms and health. Using innovative approaches to analysing proxies for gender norms, we generated evidence that gender norms impact the health of women and men across life stages, health sectors, and world regions.

[Series] Gender inequality and restrictive gender norms: framing the challenges to health

Thu, 13 Jun 2019 23:00:08 +0000

Gender is not accurately captured by the traditional male and female dichotomy of sex. Instead, it is a complex social system that structures the life experience of all human beings. This paper, the first in a Series of five papers, investigates the relationships between gender inequality, restrictive gender norms, and health and wellbeing. Building upon past work, we offer a consolidated conceptual framework that shows how individuals born biologically male or female develop into gendered beings, and how sexism and patriarchy intersect with other forms of discrimination, such as racism, classism, and homophobia, to structure pathways to poor health.

[Clinical Picture] Isolated cardiac cysticercosis: treatment with or without steroids?

Thu, 13 Jun 2019 23:00:08 +0000

A 35-year-old man presented to our department with palpitations and mild shortness of breath. He was of Haitian origin and had emigrated to the USA when he was 24 years old. A physical examination, an electrocardiogram (ECG), a full blood count, and a comprehensive metabolic profile showed no abnormalities. However, a transthoracic echocardiogram showed a 3 cm × 2 cm echolucent lesion in the apex of the left ventricle (figure; video 1). The patient did not report having a fever or any other systemic problems, but he had been to Haiti 5 months earlier.

[Articles] Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study

Thu, 13 Jun 2019 23:00:08 +0000

Our results provide a similar level of evidence on viral suppression and HIV transmission risk for gay men to that previously generated for heterosexual couples and suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero. Our findings support the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV.

[Articles] Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial

Thu, 13 Jun 2019 23:00:08 +0000

Significantly greater clinical improvements were shown in rickets severity, growth, and biochemistries among children with X-linked hypophosphataemia treated with burosumab compared with those continuing conventional therapy.

[Articles] Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial

Thu, 13 Jun 2019 23:00:08 +0000

Atezolizumab plus bevacizumab prolonged progression-free survival versus sunitinib in patients with metastatic renal cell carcinoma and showed a favourable safety profile. Longer-term follow-up is necessary to establish whether a survival benefit will emerge. These study results support atezolizumab plus bevacizumab as a first-line treatment option for selected patients with advanced renal cell carcinoma.

[Articles] Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial

Thu, 13 Jun 2019 23:00:08 +0000

This trial shows benefit of a single dose of prophylactic antibiotic after operative vaginal birth and guidance from WHO and other national organisations should be changed to reflect this.

[Department of Error] Department of Error

Thu, 13 Jun 2019 23:00:08 +0000

The Ebola Gbalo Research Group. Responding to the Ebola virus disease outbreak in DR Congo: when will we learn from Sierra Leone? Lancet 2019; published online May 29. http://dx.doi.org/10.1016/S0140-6736(19)31211-5—An appendix with a translated French version has been added to this Viewpoint, and Meinie Nicolai's title has been corrected from “MSF's general director” to “a general director for MSF”. These corrections have been made to the online version as of May 31, 2019, and will be made to the printed Viewpoint.

[Department of Error] Department of Error

Thu, 13 Jun 2019 23:00:08 +0000

Knight M, Chiocchia V, Partlett C, et al. Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial. Lancet 2019; published online May 13. 393: 2395–403—In this Article, members of the ANODE collaborative group have now been listed at the end of the Article. The Contributors statement has also been corrected to include the contributions of the ANODE collaborative group members. These corrections have been made to the online version as of June 13, 2019, and the printed Article is correct.

[Department of Error] Department of Error

Thu, 13 Jun 2019 23:00:08 +0000

Smit JG, Kasius JC, Eijkemans MJC, et al. Hysteroscopy before in-vitro fertilisation (inSIGHT): a multicentre, randomised controlled trial. Lancet 2016; 387: 2622–29—During analysis of data from the OPTIMIST trial, a discrepancy was discovered in the reporting of the primary outcome of inSIGHT in this Article, which necessitated reanalysis of the primary outcome. Corrections have been made to the summary findings, the main results section, figure 2, and table 2. No risk ratio changed by more than 0·01.

[Department of Error] Department of Error

Thu, 13 Jun 2019 23:00:07 +0000

Näslund U, Ng N, Lundgren A, et al. Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial. Lancet 2019; 393: 133–42—In this study, two variables were used to record sex, and the variable used in this Article was the one with manual recording, not the one that was automatically imported from the ID registry. The mistaken manual recording of sex was found in 52 of 3532 individuals, randomly spread between groups.

[Correspondence] How can we avoid making universal health coverage a white elephant?

Thu, 13 Jun 2019 23:00:07 +0000

When Irene A Agyepong1 discussed the potential risk of universal health coverage (UHC) becoming a white elephant in low-income and low-income and lower-middle-income countries, she also demonstrated how, from 1945 to 2019, global dominant ideologies have been alternating between vertical and horizontal approaches to UHC, with the exception of Ghana.

[Correspondence] Dyspnoea in the GLOBAL LEADERS trial – Authors' reply

Thu, 13 Jun 2019 23:00:07 +0000

We thank David Martí and Marcelo Sanmartín for their interest in GLOBAL LEADERS.1 Dyspnoea was reported in 1642 (13·8%) of 11 936 patients ever treated with ticagrelor after 2 years of follow-up in GLOBAL LEADERS versus 1270 (11·4%) of 9235 patients after 1 year of follow-up in the PLATO study2 and 1205 (17·2%) of 6988 patients allocated to ticagrelor 90 mg twice daily in the PEGASUS trial, after a median follow-up of 33 months.3 Discontinuation of ticagrelor because of dyspnoea was reported in only 79 patients in the PLATO study after 1 year of follow-up.

[Correspondence] Dyspnoea in the GLOBAL LEADERS trial

Thu, 13 Jun 2019 23:00:07 +0000

Pascal Vranckx and colleagues1 reported that extended ticagrelor monotherapy was not superior to the standard dual antiplatelet therapy after stenting. Although we agree that the results do not support a change from current practice, we are concerned about the high incidence of discontinuation due to dyspnoea during the study period.

[Correspondence] ABSORB IV: will the low rate of scaffold thrombosis persist? – Authors' reply

Thu, 13 Jun 2019 23:00:07 +0000

We thank Ruben Tijssen and colleagues for their interest in our work.1 We agree with most of their comments. Specifically, we note in our Article that more careful patient selection and greater attention to procedural technique in ABSORB IV compared with ABSORB III were associated with lower stent thrombosis rates after implantation of metallic drug-eluting stents as well as bioresorbable vascular scaffolds. Despite these efforts, thrombosis events have not been eliminated (with either device), especially in complex lesions, as seen in every large stent study in which careful clinical follow-up was done.

[Correspondence] ABSORB IV: will the low rate of scaffold thrombosis persist?

Thu, 13 Jun 2019 23:00:07 +0000

Gregg Stone and colleagues1 reported the results of the ABSORB IV randomised trial, which including non-inferiority testing for the primary endpoint of target lesion failure at 30 days. The rate of scaffold thrombosis was 0·7% at 1 year.

[Correspondence] Alcohol and the global burden of disease – Authors' reply

Thu, 13 Jun 2019 23:00:07 +0000

We synthesised data from 694 surveys and 592 prospective and retrospective studies to estimate the global burden of disease attributable to alcohol use. As part of that analysis, we calculated a theoretical minimum risk exposure level (TMREL) of alcohol use.1 We found that risk increases monotonically with dose and the minimal exposure to risk was zero drinks per day. Although we reached this conclusion using a new method, our results are consistent with those of other studies.2–4 These findings are further bolstered by results in mendelian randomisation trials, which have not found a protective effect between alcohol use and ischaemic heart disease.

[Correspondence] Alcohol and the global burden of disease

Thu, 13 Jun 2019 23:00:07 +0000

The Global Burden of Disease (GBD) Alcohol Collaborators1 estimate the burden of alcohol consumption on populations from 195 locations and conclude that drinking alcohol leads to health loss regardless of the quantity consumed and question the need for revising alcohol control policies worldwide.

[Correspondence] Alcohol and the global burden of disease

Thu, 13 Jun 2019 23:00:07 +0000

We read the paper by the GBD 2016 Alcohol Collaborators1 with great interest. However, we are surprised that, on the basis of mainly ecological data and predominantly mathematical models, the authors suggest the need for a revision of alcohol control policies worldwide.

[Correspondence] Alcohol and the global burden of disease

Thu, 13 Jun 2019 23:00:07 +0000

The 2016 Global Burden of Disease (GBD) Alcohol Collaborators1 corroborate that alcohol is a leading risk factor for the global burden of disease; however, limitations in the methods have led to the unfounded conclusion that, at the individual level, no amount of alcohol consumption benefits health.

[Correspondence] Alcohol and the global burden of disease

Thu, 13 Jun 2019 23:00:07 +0000

We read with interest the systematic anlysis of the global burden of alcohol use by the Global Burden of Disease (GBD) 2016 Alcohol Collaborators.1

[Correspondence] Ongoing pregnancy as the primary outcome for the inSIGHT study

Thu, 13 Jun 2019 23:00:07 +0000

The inSIGHT study1 was a randomised controlled trial investigating the effect of routine hysteroscopy before the first in-vitro fertilisation (IVF) or intracytoplasmic sperm injection treatment on livebirth rate. The trial included 750 subfertile women, who were randomly allocated to either hysteroscopy with treatment of detected intracavity abnormalities before IVF or immediate start of IVF at 22 centres in the Netherlands between May, 2011, and August, 2013. The results showed that routine hysteroscopy before IVF did not improve the rate of livebirths.

[Obituary] John Lennard-Jones

Thu, 13 Jun 2019 23:00:07 +0000

Pioneering gastroenterologist. He was born in Bristol, UK, on Jan 29, 1927, and died in Woodbridge, UK, on March 29, 2019, aged 92 years.

[Perspectives] Gender equality: engaging men in change

Thu, 13 Jun 2019 23:00:07 +0000

I have been working on issues of men, masculinities, and gender for 32 years, and it looks to me like men's roles in building gender equality are now part of the public agenda to an unprecedented extent. Almost every day, there are new stories and initiatives on how men can support women's participation in medicine and science, end domestic and sexual violence, share the load of fathering and housework, and more. This focus has a compelling rationale. Above all, we will not make much progress towards gender equality without change among men—and men themselves will benefit from this progress.

[Perspectives] Sarah Hawkes: shining a gender lens on global health

Thu, 13 Jun 2019 23:00:07 +0000

“A deafening silence” is how Sarah Hawkes, Director of the Centre for Gender and Global Health at University College London (UCL), UK, recalls the reaction to a 2013 Lancet Viewpoint on gender and global health that she wrote with her husband Kent Buse. Its inclusive gender-based approach “was deemed politically unacceptable at the time, as most gender-based discussions in global health had hitherto focused on maternal health, in the context of sexual health and HIV”, she says. The agenda has now changed and a new Lancet Series examines gender equality, norms, and health.

[Perspectives] Making women equally visible

Thu, 13 Jun 2019 23:00:07 +0000

Caroline Criado Perez is a feminist probably most famous in the UK for successfully campaigning to have a woman depicted on Bank of England notes and a statue of suffragist Millicent Fawcett erected in Parliament Square. Her book Invisible Women: Exposing Data Bias in a World Designed for Men describes the avoidable adversities women experience when they inhabit a world designed by default to fit men.

[World Report] Pharma blockchains AI for drug development

Thu, 13 Jun 2019 23:00:07 +0000

The venture would allow AI to be trained on millions of datapoints across databases from several drug companies without threatening the ownership and privacy of the data. Talha Burki reports.

[World Report] Trump administration limits fetal tissue research

Thu, 13 Jun 2019 23:00:07 +0000

The move could threaten medical research advances, say scientists, as acquisition of new fetal tissue for research is substantially hindered. Susan Jaffe reports.

[World Report] Health targeted in Sudan's political transition

Thu, 13 Jun 2019 23:00:07 +0000

As the country organises after its former leader's decade-long rule was ended, violence has been rife, with up to 113 people killed at a civilian protest in early June. Sharmila Devi reports.

[Comment] Reducing the global burden of depression: a Lancet–World Psychiatric Association Commission

Thu, 13 Jun 2019 23:00:06 +0000

Depression is the leading cause of mental health-related disease burden globally, affecting an estimated 300 million people worldwide.1 It represents a barrier to sustainable development in all regions.2 Depression prevents people from reaching their full potential, impairs human capital, and is associated with premature mortality from suicide and other illnesses.1

[Comment] Offline: A Chief Medical Officer—unplugged

Thu, 13 Jun 2019 23:00:06 +0000

“We have very little power.” Professor Dame Sally Davies, England's Chief Medical Officer (CMO) for the past 9 years, was giving her final evidence last week to the House of Commons Science and Technology Committee. Her encounter before politicians who independently scrutinise government policies on all aspects of science was unexpectedly revealing. A CMO sits in an unusual position. She is the principal adviser to government on all medical and public health matters. That role would seem to make her extremely powerful.

[Comment] Alcohol policy in the UK: where next?

Thu, 13 Jun 2019 23:00:06 +0000

Britain's Drink Problem, the episode of BBC's Panorama that aired on June 10, 2019, highlighted the UK Government's continuing failure to take effective action to address the worrying rates of alcohol harm in the country. As the Lancet Standing Commission on Liver Disease in the UK1 has documented, the level of deaths and illness from alcohol are concerning; there were 1·1 million hospital admissions related to alcohol in England during 2016–17 and 7697 alcohol-specific deaths in the UK in 2017.

[Comment] Why now for a Series on gender equality, norms, and health?

Thu, 13 Jun 2019 23:00:06 +0000

When this Series on gender equality, norms, and health was first conceptualised in 2015, we were surprised by how little targeted effort and impact had been achieved at this intersection, despite compelling evidence that gender equality improves health and wellbeing.1,2 The 2030 Agenda for Sustainable Development and the universal health coverage goals demand greater attention to the social determinants of health, including gender, and more integrated, multisectoral programming to enable all people to reach their full human potential.

[Comment] A new normal: addressing gender to improve health

Thu, 13 Jun 2019 23:00:06 +0000

Gender norms shape the daily lives of every person on the planet. Since the Bill & Melinda Gates Foundation is dedicated to the principle that everyone should have the opportunity to lead a healthy and productive life, we are especially interested in understanding how these norms negatively affect health. That is why we were so excited to co-fund the work that formed the basis for this Lancet Series on gender equality, norms, and health,1–5 along with the United Arab Emirates Ministry of Foreign Affairs and International Cooperation.

[Comment] Doing gender better: can the UN step up?

Thu, 13 Jun 2019 23:00:06 +0000

Gender inequality and gender norms impede progress on the global goal to achieve health for all. The Lancet's 2019 theme issue on advancing women in science, medicine, and global health and now its new Series on gender equality, norms, and health1–5 provide updated evidence on the pervasiveness of gender inequities, unequal power dynamics, and other intersecting factors within society that often leave women disempowered, disenfranchised, and vulnerable. In their Series paper, Geeta Rao Gupta and colleagues5 remind us that the barriers to progress are primarily political, which gives the UN a distinct role to advocate for political commitment, ensure accountability to international instruments, and enable gender transformative implementation with the right tools, resources, and evidence.

[Comment] Gender equality and health: laying the foundations for change

Thu, 13 Jun 2019 23:00:06 +0000

The gender equality and women's empowerment agenda is recognised in the Sustainable Development Goals (SDGs) and by various UN and government commitments before the SDGs. However, mainstream public health and public policy have yet to invest substantially in research and action to tackle gender inequalities in health. Building on the Women and Gender Equity Knowledge Network (WGEKN) report submitted to the WHO's Commission on Social Determinants of Health,1 the new Lancet Series on gender equality, norms, and health2–6 brings back to the foreground the urgency with which attention, resources, action, and accountability must be dedicated to transform gender inequalities in health.

[Comment] A coming of age for gender in global health

Thu, 13 Jun 2019 23:00:06 +0000

An abundance of evidence shows health outcomes and experiences to be different for women and men, and this is true across time, space, and culture. The impact of biological sex accounts for a fraction of these differences; gender explains the rest. Gender refers to the social phenomena and relationships of males and females in terms of their roles, attributes, and opportunities.1 In health and otherwise, advantage and privilege are largely the domain of maleness and men. That gender is socially constructed means these injustices can change.

[Comment] Successful treatment of HIV eliminates sexual transmission

Thu, 13 Jun 2019 23:00:06 +0000

In December, 2011, Science recognised the findings of the HPTN 052 study1 as the scientific breakthrough of the year.2 This study showed a 96% reduction in sexual transmission of HIV in serodifferent couples (one partner HIV positive, the other HIV negative) when the HIV-positive partner was successfully treated with antiretroviral therapy (ART).1 However, the HPTN 052 study included only a small number of men who have sex with men (MSM), for whom HIV acquisition often includes anal exposure, an efficient route of HIV transmission.

[Comment] Burosumab treatment of children with X-linked hypophosphataemic rickets

Thu, 13 Jun 2019 23:00:06 +0000

X-linked hypophosphataemia is the most common form of genetic rickets, and is characterised by low circulating concentrations of phosphorus that impair skeletal mineralisation and result in rickets in growing children and osteomalacia in adults.1 X-linked hypophosphataemia is caused by mutations in PHEX (phosphate-regulating endopeptidase homolog, X-linked), which encodes a transmembrane endopeptidase.2 Although the mechanism is uncertain, loss of PHEX leads to raised plasma concentrations of fibroblast growth factor 23 (FGF23), the best-characterised member of a family of phosphate-regulating hormones termed phosphatonins.

[Comment] Durable complete response in renal cell carcinoma clinical trials

Thu, 13 Jun 2019 23:00:06 +0000

Renal cell carcinoma is one of the most common urological cancers and its incidence is on the rise.1 Outcomes for patients with advanced renal cell carcinoma have improved substantially with the advent of vascular endothelial growth factor (VEGF)-targeted drugs, and with the approval of immune checkpoint blocking antibodies in the past 4 years.2 Although each of these drug classes has shown single drug efficacy, responses remain transient for most patients, culminating in a high proportion of patients eventually having disease progression or death.

[Comment] Antibiotics for operative vaginal delivery: practice-changing data

Thu, 13 Jun 2019 23:00:06 +0000

The large randomised controlled trial on the effect of antibiotics to prevent infection after operative vaginal delivery by Marian Knight and colleagues1 in The Lancet is practice changing. Operative vaginal deliveries include either vacuum or forceps, and are used in about 2–15% of births.2 Even if one conservatively estimates 2% of babies are born by operative vaginal delivery globally, about 2 700 000 of the world's 135 million annual births are operative vaginal deliveries. Up to 16% of these births can be associated with infection without antibiotics prophylaxis,3 representing about 432 000 annual infections associated with operative vaginal delivery worldwide.

[Editorial] Venezuela: food and medicines used as weapons

Thu, 13 Jun 2019 23:00:06 +0000

When Nicolás Maduro was first elected in April, 2013, he ambitiously aimed for “zero poverty” by 2019. Now, Venezuela's economy is collapsing, with people becoming even more impoverished. Those living without access to food and medicine display the reality of an unprecedented humanitarian emergency in the country. On June 7, the UN stated that more than 4 million people have already left Venezuela, while a further 7 million need humanitarian assistance. Maduro's strategy in the face of such a catastrophe includes the control of food production and distribution, and subsidising food handouts as a political weapon.

[Editorial] Recognising physicians with impairment

Thu, 13 Jun 2019 23:00:06 +0000

The Ethics, Professionalism, and Human Rights Committee of the American College of Physicians (ACP) published a position paper on June 4, Physician impairment and rehabilitation: reintegration into medical practice while ensuring patient safety. Opening with the words “physician impairment, the inability to carry out patient care responsibilities safely and effectively, is a problem of functioning”, the paper explores the difference between illness and impairment.

[Editorial] The devastating impact of Trump's global gag rule

Thu, 13 Jun 2019 23:00:06 +0000

About 56 million abortions are done annually, and almost half (25 million) are unsafe, of which 97% occur in developing countries. An estimated 8% of all maternal deaths are due to abortion, leaving a massive unmet global need for access to safe abortion services. Despite this situation, the USA, the world's largest global health donor, takes a hardline stance against abortion both at home and abroad. On June 5, the International Women's Health Coalition launched Crisis in care: year two impact of Trump's global gag rule, detailing the direct effect of anti-abortion policies and the broader ways in which they are threatening the work of non-governmental organisations (NGOs) that support women and vulnerable groups around the world.

Fecal Transplants May Transmit Drug-Resistant Infections: FDA

Thu, 13 Jun 2019 17:19:14 +0000

The FDA warns about the potential risk for serious or life-threatening infections with the use of investigational fecal microbiota for transplant.
News Alerts

Initial Volume Overload Tied to Death in Peritoneal Dialysis

Thu, 13 Jun 2019 17:32:44 +0000

Largest study to date finds volume overload at start of peritoneal dialysis tied to increased death. Men and those with diabetes had higher levels of volume overload; dialysis practices vary around the world.
Medscape Medical News

Minors Can Consent to Vaccines, Delegates Back State Laws

Thu, 13 Jun 2019 16:39:35 +0000

The American Medical Association (AMA) House of Delegates also adopted a resolution to eliminate exemptions and to provide asylum seekers with access to healthcare, including vaccinations.
Medscape Medical News

New JAK Inhibitor for Rheumatoid Arthritis Hits Targets

Thu, 13 Jun 2019 14:50:38 +0000

Filgotinib is effective and well tolerated by patients with moderate to severe rheumatoid arthritis, early phase 3 results show, and investigators speculate it will enter the market in about 2 years.
Medscape Medical News

Sleep-Disordered Breathing Tied to Accelerated Aging

Thu, 13 Jun 2019 15:25:45 +0000

Untreated sleep-disordered breathing and the sleep disruption it causes is associated with epigenetic age acceleration, especially in women.
Medscape Medical News

ICD2: No Survival Benefit With ICDs in Dialysis Patients

Thu, 13 Jun 2019 15:27:53 +0000

Sudden cardiac death contributes to high mortality in patients receiving dialysis. A new study shows prophylactic implantation of a defibrillator confers no survival benefit.
Medscape Medical News

Spotting Difficult-to-Diagnose Skin Cancers

Thu, 13 Jun 2019 15:44:31 +0000

Hard-to-identify lesions can lead to clinical misses and misdiagnoses. Specialists attending the World Congress of Dermatology discuss 'great masqueraders' and what to do about them.
Medscape Medical News

High BP and HbA1c: Similar Risks for CVD in Youth With Type 1 Diabetes

Thu, 13 Jun 2019 14:32:58 +0000

Blood pressure is as important a risk factor as glycemic control for cardiovascular events in young people with type 1 diabetes. Risk doubles if blood pressure is ≥ 120/80 mmHg, new data show.
Medscape Medical News

Ученые: Два часа наслаждения природой в неделю - необходимый для здоровья минимум

Thu, 13 Jun 2019 20:45:36 +0000

Британские ученее высчитали, сколько времени нужно проводить на природе, чтобы это действительно положительно отразилось на здоровье: два часа в неделю. Авторы отмечают, что для получения пользы не требуется ничего дополнительного, можно просто любоваться видом. Научная работа была опубликована в журнале Scientific Reports.

Hashtag Medicine: Abstract Tweeted at ASCO Ignites Debate

Thu, 13 Jun 2019 13:38:01 +0000

A tweet about how male and female presenters are introduced differently at ASCO meetings was divisive.
Medscape Medical News

New Coalition Pushes 2020 Candidates to Prioritize Mental Health

Thu, 13 Jun 2019 13:48:37 +0000

A new coalition of mental health professionals and organizations has been organized to pressure 2020 candidates to commit to policies that will improve mental health in the United States.
Medscape Medical News

Delicate Balance: Aspirin Reduces Events, Increases Bleeding

Thu, 13 Jun 2019 09:20:29 +0000

A new meta-analysis of randomized trials 'represents the largest and most contemporary examination of long-term outcomes with aspirin use for primary prevention of CVD,' researchers say.
Medscape Medical News

Restless Legs Syndrome Tied to Gut Health

Thu, 13 Jun 2019 11:59:38 +0000

Small intestinal bacterial overgrowth may be more prevalent in patients with restless legs syndrome, suggesting a link between gut health and the sleep disorder.
Medscape Medical News

Immune Booster Celebrated for Asthma Prevention

Thu, 13 Jun 2019 12:29:41 +0000

Bacterial lysate, a cocktail of 21 microbial species commonly used in Europe, purportedly decreases asthma and wheezing in children and specialists are taking notice.
Medscape Medical News

Immunotherapies Can Kill Money Bonuses in OC Model

Thu, 13 Jun 2019 12:43:46 +0000

The US government's experiment with value-based payment in oncology is motoring along, but immunotherapy costs are a big bump in the road.
Medscape Medical News

How Measles Detectives Work to Contain an Outbreak

Thu, 13 Jun 2019 10:22:03 +0000

From interviews to scouring records, public health department investigators do a lot of legwork to determine who might have been exposed. This year's measles outbreak is the nation's worst in 27 years.
Kaiser Health News

New SCAI Statement on Classification of Cardiogenic Shock

Thu, 13 Jun 2019 10:31:34 +0000

Patients presenting with cardiogenic shock run the gamut from mildly ill to near death. This statement presents a first-ever classification to create a common lexicon for rapid triage.
Medscape Medical News

«Российская школа колоректальной хирургии» отметила свой десятилетний юбилей

Thu, 13 Jun 2019 13:59:41 +0000

Двенадцать операций в режиме реального времени, более 30 лекторов с мировым именем, 18 баллов НМО, церемония открытия, креативности которой могли бы позавидовать самые удачные «домашние задания» в клубе КВН, и извечный спор хирургов Востока и Запада. Все это – XII Международная конференция «Российская школа колоректальной хирургии», прошедшая 7-9 июня в Москве.

Delicate Balance: Aspirin Reduces Events, Increases Bleeding

Thu, 13 Jun 2019 09:20:29 +0000

Aspirin is used for prevention in people with known cardiovascular risk, but should it be used prophylactically in patients without risk factors? The risks may outweigh the benefits, a meta-analysis of randomized trials concludes.
Medscape Medical News

New Guidelines Issued on Sexually Transmitted Infections

Thu, 13 Jun 2019 08:27:36 +0000

Recommendations address dermatologic manifestations that are not always included in guidelines from other groups, such as the need to diagnose and treat genital lumps and lacerations.
Medscape Medical News

«Российская школа колоректальной хирургии» отметила свой десятилетний юбилей

Thu, 13 Jun 2019 13:59:41 +0000

Более 15 операций в режиме реального времени, более 30 лекторов с мировым именем, 18 баллов НМО, церемония открытия, креативности которой могли бы позавидовать самые удачные «домашние задания» в клубе КВН, и извечный спор хирургов Востока и Запада. Все это – XII Международная конференция «Российская школа колоректальной хирургии», прошедшая 7-9 июня в Москве.

House Panel Digs In on Medicare for All, Other Insurance Options

Thu, 13 Jun 2019 07:15:01 +0000

A hearing by the House Ways and Means Committee on various plans for expanding insurance coverage previewed debates that likely will dominate health policy for many years.
Medscape Medical News

Исследование: Сохранение нежелательной беременности вреднее для здоровья женщины, чем аборт

Thu, 13 Jun 2019 12:00:48 +0000

Согласно новому американскому исследованию, при нежелательной беременности аборт менее опасен для здоровья женщин в будущем, чем роды. Научная работа опубликована в журнале Annals of Internal Medicine. Ученые обнаружили, что у женщин, которым отказали в аборте пять лет назад, здоровье оказалось хуже, чем у женщин, которые сделали аборт на первом или втором триместре.

Muscle-Pump Activator Cuts Hospital Time, Edema After Kidney Transplantation

Thu, 13 Jun 2019 01:55:45 +0000

Switching standard compression stockings for muscle-pump activators (MPAs) on a kidney-transplantation patient's legs cuts hospitalization time and improves short-term outcomes, a new randomized trial suggests.
Reuters Health Information

Consistent Bedtime Routines Help Children's Sleep Self-Control

Thu, 13 Jun 2019 02:26:24 +0000

Using consistent bedtime strategies such as allowing infants to fall asleep on their own can improve their sleep, New Zealand researchers say.
Reuters Health Information

Large UK Audit of FreeStyle Libre: Improved HbA1c, Marked Drop in Admissions

Thu, 13 Jun 2019 01:46:48 +0000

UK audit of FreeStyle Libre shows a drop in HbA1c, a reduction in hypoglycaemia rate including nocturnal hypos, reduced duration of hypos, and reduced hospital admissions for diabetic ketoacidosis, hyperglycaemia and hypoglycaemia.
Medscape News UK

Germany May Ban 'Conversion Therapies' for Gays

Thu, 13 Jun 2019 00:36:04 +0000

Germany is considering a ban of so-called "conversion therapies" aimed at changing the sexual orientation of gay people, the health minister said on Tuesday.
Reuters Health Information

Record Deaths From Suicide, Drugs, in Youth a 'National Tragedy'

Thu, 13 Jun 2019 00:29:20 +0000

A major increase in the number of young American adults lost to substance misuse and suicide is being described as a national tragedy.
Medscape Medical News

Mortality May Increase as Red Meat Consumptions Rises

Wed, 12 Jun 2019 19:44:13 +0000

Data from large prospective cohorts suggest that increased red meat consumption was tied to higher mortality, whereas replacing red meat with healthier alternatives may lower risk for death.
Medscape Medical News

Teva Pharmaceuticals Expands Patient-Level Losartan Recall

Wed, 12 Jun 2019 18:29:28 +0000

The new recall of six lots brings the total to 41 lots of bulk losartan potassium sold to Golden State Medical Supply of California.
News Alerts

Chemo Alone in Advanced Endometrial Cancer?

Wed, 12 Jun 2019 17:06:42 +0000

Chemotherapy plus radiation was not associated with longer relapse-free survival than chemotherapy alone in patients with advanced endometrial carcinoma.
Medscape Medical News

FDA Overlooked Red Flags in Drugmaker's Testing of New Depression Medicine

Wed, 12 Jun 2019 16:06:12 +0000

In March, esketamine was approved by the FDA for the treatment of intractable depression, but critics say the FDA was given little evidence of the drug's efficacy and its safety for long-term use.
Kaiser Health News

Bats Now Pose Greatest Risk for Rabies in the US

Wed, 12 Jun 2019 16:31:50 +0000

The main source of most human rabies infections has shifted from dogs to bats, which now cause about 70% of deaths in people infected with rabies.
Medscape Medical News

Premenopausal Women With Breast Cancer; New TAILORx Data

Wed, 12 Jun 2019 15:20:00 +0000

An analysis of TAILORx showed that adding clinical risk refines its genomic risk model and may now identify a group of premenopausal women who may benefit from chemotherapy added to endocrine therapy.
Medscape Medical News

Growing Doubt, Uncertainty Over PDE5i Use in Left Heart Disease

Wed, 12 Jun 2019 14:19:07 +0000

Off-label preoperative use was linked to an increase in severe early right heart failure after LVAD implantation, even after propensity matching for 22 variables.
Medscape Medical News

Mindfulness App Alters Brain Reactivity, Cuts Cigarette Use

Wed, 12 Jun 2019 12:53:44 +0000

Cravings frequently derail smoking cessation. A study suggests that a particular brain region is implicated in cravings and may be deactivated through use of a mindfulness-based app.
Medscape Medical News

Robotic Surgery vs Radiation in Oropharyngeal Cancer

Wed, 12 Jun 2019 11:53:38 +0000

The only trial directly comparing the two modalities found better swallowing outcomes with radiotherapy, but no difference in survival.
Medscape Medical News

US Deaths From Suicide, Drugs, Alcohol Reach Crisis Levels

Wed, 12 Jun 2019 12:11:46 +0000

Deaths from suicide, alcohol, and drug overdoses are reaching crisis levels across the nation, although individual states are affected in dramatically different ways, a new report shows.
Medscape Medical News

Clinicians Warned About Social Media #BoundaryViolations

Wed, 12 Jun 2019 11:51:20 +0000

As physicians' social media use has increased, experts are warning clinicians about potential pitfalls and are offering advice on how to maintain appropriate boundaries with their patients.
Medscape Medical News

FAQ: How Does New Fetal Tissue Policy Impact Medical Research?

Wed, 12 Jun 2019 10:14:02 +0000

Under the new policy, employees at the National Institutes of Health will no longer conduct research with human fetal tissue obtained from elective abortions. Scientists say research will be affected.
Kaiser Health News

Do You Consider Cost When Prescribing a Drug?

Wed, 12 Jun 2019 06:51:49 +0000

A newly approved gene therapy for children with spinal muscular atrophy will cost more than $2 million for a one-time infusion.
Medscape Reader Polls

USPSTF Now Recommends Preexposure Prophylaxis for HIV

Wed, 12 Jun 2019 00:29:38 +0000

Clinicians should screen adolescents, adults, and pregnant people, and offer PrEP to those at high risk for HIV infection, according to the US Preventive Services Task Force.
Medscape Medical News

PIONEER 6: Will Oral Semaglutide Live Up to Promise in Real World?

Tue, 11 Jun 2019 22:03:52 +0000

The CV outcomes trial for the first oral version of a GLP-1 agonist shows semaglutide is safe in patients with type 2 diabetes at high cardiovascular risk, but results not as impressive as with other agents.
Medscape Medical News

CAROLINA Reassures on CV Safety for Linagliptin, Glimepiride in T2D

Tue, 11 Jun 2019 20:00:44 +0000

"We think we've vindicated sulfonylureas, at least glimepiride specifically," says an expert, who notes trial findings do inform decision-making, particularly when cost is an issue.
Medscape Medical News

Medical Cannabis No Solution to the Opioid Crisis

Tue, 11 Jun 2019 18:34:01 +0000

Based on previous research, cannabis has been enthusiastically embraced as a means to reduce opioid overdose. That conclusion is mistaken, this study finds.
Medscape Medical News

Little Difference With Oral Semaglutide vs Liraglutide in Diabetes

Tue, 11 Jun 2019 18:50:13 +0000

PIONEER 4 trial shows noninferiority of oral semaglutide to liraglutide for HbA1c lowering, while PIONEER 7 shows superior glycemic control and weight loss compared with the DPP-4 inhibitor sitagliptin.
Medscape Medical News

Dwindling Support, Lawsuits Blamed for Pain Society's Demise

Tue, 11 Jun 2019 16:52:23 +0000

Declining membership, a reduction in industry support, and opioid lawsuits have all led to the demise of the AIPM, an organization that promoted integrative approaches to pain management.
Medscape Medical News

CDC Data Show Cancer, Heart Disease Mortality Trending Down

Tue, 11 Jun 2019 16:59:46 +0000

The CDC's National Center for Health Statistics has released its most current quarterly data of provisional mortality rates for several top causes of death in the United States.
Medscape Medical News

Infusion Centers Help Navigate Cost of Care

Tue, 11 Jun 2019 17:09:27 +0000

Ambulatory infusion centers address the needs of their patients and can deliver therapy at half the cost of hospitals, experts report at the National Infusion Center Association Meeting.
Medscape Medical News

Reassurance on TAVR for Bicuspid Valves

Tue, 11 Jun 2019 17:19:16 +0000

A large registry study has shown similar outcomes for the transcatheter procedure in patients with bicuspid valves as those with tricuspid valves although some selection bias may have occurred.
Medscape Medical News

Ordering Advanced Imaging? Get Ready for New Medicare Rules

Tue, 11 Jun 2019 16:18:31 +0000

Starting in January 2020, Medicare will require that providers use a certified clinical decision support system when ordering advanced imaging tests for eight common conditions.
Medscape Medical News

Doctors Expected a Brain Tumor. It Was a Tapeworm

Tue, 11 Jun 2019 14:50:46 +0000

The Middletown, New York woman, 42, was diagnosed with neurocysticercosis, a rare parasitic infection of the brain that can develop if a person swallows the eggs of the pork tapeworm.
WebMD Health News

AMA Reaffirms Stance Against Physician-Aided Death

Tue, 11 Jun 2019 14:33:25 +0000

The decision drew support and criticism from patient advocacy groups after the Council on Ethical and Judicial Affairs re-examined the issue in response to a request at last year's annual meeting.
Medscape Medical News

Six Brain Surgeries Later, This Med Student Is Excelling

Tue, 11 Jun 2019 14:46:54 +0000

Claudia Martinez was a college student chasing her dream of becoming a doctor when a neurosurgeon gave her alarming advice: Get brain surgery as soon as possible for chiari malformation.
WebMD Health News

Вакцинация от ветряной оспы сильно снижает заболеваемость опоясывающим лишаем

Tue, 11 Jun 2019 18:15:20 +0000

Дети, вакцинированные против ветряной оспы, значительно реже заболевают опоясывающим лишаем, согласно новому исследованию, проведенному Центром медицинских исследований Kaiser Permanente и опубликованному в Pediatrics.

Alzheimer's Drug May Help Treat Opioid Addiction

Tue, 11 Jun 2019 12:18:05 +0000

Preliminary data suggest cholinesterase inhibitors may have a therapeutic role in opioid use disorder.
Medscape Medical News

More DECLARE-TIMI: Robust Renal Effects of Dapagliflozin

Tue, 11 Jun 2019 12:34:04 +0000

A new analysis from the landmark trial with the diabetes drug dapagliflozin shows a large, robust effect on important kidney outcomes. Accumulating data support 'leading role for SGLT2 inhibitors,' in diabetes.
Medscape Medical News

Rates of Self-Harm Soar, Especially Among Girls, Young Women

Tue, 11 Jun 2019 12:36:33 +0000

Rates of nonsuicidal self-harm have tripled since 2000, especially among adolescent girls and young women.
Medscape Medical News

Вакцинация от ветряной оспы сильно снижает заболеваемость опоясывающим лишаем

Tue, 11 Jun 2019 18:15:20 +0000

Дети, вакцинированные против ветряной оспы, значительно реже заражаются опоясывающим лишаем, согласно новому исследованию, проведенному Центром медицинских исследований Kaiser Permanente и опубликованному в Pediatrics.

Acute Sleep Loss Increases Blood Levels of Alzheimer's Biomarker

Tue, 11 Jun 2019 11:32:55 +0000

Acute sleep loss results in increased plasma levels of tau, which has been proposed as a biomarker to assess subsequent risk of Alzheimer's disease.
Medscape Medical News

More Evidence Supports Later School Start Times for Teens

Tue, 11 Jun 2019 11:37:51 +0000

Delayed school start times help middle and high school students get more sleep and focus better when it's time to do homework, new research shows.
Medscape Medical News

Гипертония белого халата увеличивает риск болезней сердца и вероятность смерти от них

Tue, 11 Jun 2019 16:59:18 +0000

О «гипертонии белого халата» говорят, когда у пациента повышается артериальное давление в тот момент, когда он на приеме у врача или медицинский работник измеряет ему давление. Обычно этот феномен объясняли тем, что пациенты могут испытывать беспокойство при посещении медицинских учреждений. Однако впоследствии исследования показали, что это может быть признаком риска развития

Attractiveness May Help Applicants Land Residency Interviews

Tue, 11 Jun 2019 10:49:35 +0000

Researchers tested whether facial features and weight play a part in who makes the interviewing cut for radiology residency slots at five major academic centers.
Medscape Medical News

FDA Tests Find Toxic Chemicals in Food

Tue, 11 Jun 2019 08:09:22 +0000

The FDA for the first time has tested food on grocery store shelves for toxic grease- and stain-repelling chemicals that are known to remain in the body and the environment for long periods.
WebMD Health News

Сон при включенном телевизоре связали с набором веса и риском ожирения

Tue, 11 Jun 2019 09:40:26 +0000

Сон при включенном телевизоре или при искусственном освещении может быть фактором риска набора веса и даже развития ожирения, говорится в новом исследовании, проведенном Национальными институтами здоровья США. Это первое исследование в своем роде опубликовано в журнале JAMA Internal Medicine. Оно указывает, что ограничение света во время сна снижает эти риски.

Once-Weekly Dulaglutide Benefit in REWIND, Longest CVOT to Date

Mon, 10 Jun 2019 20:56:29 +0000

Full results of REWIND show dulaglutide significantly reduces CV events in patients with type 2 diabetes who primarily have CVD risk factors, rather than CVD itself. The major effect seems to be on stroke.
Medscape Medical News

California Set to Offer Medicaid to Undocumented Young Adults

Mon, 10 Jun 2019 17:45:55 +0000

It will become the first state to do so; California will also expand insurance subsidies for middle class residents, and the legislation will restore an individual mandate to buy health insurance.
Medscape Medical News

'Alarming' Complications in 20-Year-Olds With Type 2 Diabetes

Sun, 09 Jun 2019 11:19:08 +0000

'I think we need to recognize that...in these younger kids we probably need even more aggressive management than many adults with type 2 diabetes,' says the lead author of the TODAY-2 study.
Medscape Medical News

'Like Watching a Car Crash in Slow Motion': New RISE Data

Mon, 10 Jun 2019 16:08:54 +0000

New RISE findings inform child/adult differences in trajectory of type 2 diabetes; disease is much, much more aggressive in youth. Experts stumped as to what to do in kids both to prevent and treat it.
Medscape Medical News

FDA Approves First Chemoimmunotherapy for R/R Lymphoma Type

Mon, 10 Jun 2019 15:40:23 +0000

The FDA has granted accelerated approval to polatuzumab for previously treated diffuse large B-cell lymphoma.
FDA Approvals

Game Changer: TrialNet Is First to Delay Type 1 Diabetes Onset

Mon, 10 Jun 2019 14:06:07 +0000

Teplizumab, an investigational anti-CD3 monoclonal antibody, delayed the onset of type 1 diabetes for 2 years in patients in the TrialNet study. Experts urge caution but admit result is "terrific."
Medscape Medical News

One Cardiac Arrest. Four 911 Callers. A Tragic Outcome.

Mon, 10 Jun 2019 14:08:57 +0000

Rhode Island's 911 operators are unprepared to handle cardiac arrest calls, and Rena Fleury, 45, lost her life.
ProPublica

Barriers to Care Threaten Physicians' Progress on Opioids

Mon, 10 Jun 2019 14:23:22 +0000

Opioid prescriptions fell 33% in 5 years and the use of drug monitoring programs by physicians jumped 56% in 1 year. But barriers to care mean that patients will keep dying, an AMA report says.
Medscape Medical News

More Evidence Endorses Benefits of Long-Acting Antipsychotics

Mon, 10 Jun 2019 13:07:40 +0000

New research shows that long-acting injectable antipsychotics improve medication adherence and reduce suicide attempts compared to oral drugs, but physicians aren't prescribing them as per guidelines.
Medscape Medical News

Commercial Trackers a Good Gauge of Total Sleep Time

Mon, 10 Jun 2019 13:40:51 +0000

Commercially-available sleep tracking devices provide a 'reasonable' estimate of total sleep time in adults compared to actigraphy.
Medscape Medical News

Молодежь часто считает табачные продукты менее вредными и верит Интернету больше, чем врачам

Mon, 10 Jun 2019 19:20:12 +0000

Молодые люди с большей вероятностью, чем пожилые, будут искать медицинскую информацию в Интернете, и менее склонны считать табачные изделия «очень вредными». Об этом говорят результаты исследования, проведенного для информирования Управления по контролю за продуктами и лекарствами США (FDA). Об этом сообщает информационное агентство Reuters.

Managing Borderline Personality Disorder: New Insights

Mon, 10 Jun 2019 11:53:39 +0000

New research is investigating the potential role of electroconvulsive therapy and antipsychotics in patients with borderline personality disorder.
Medscape Medical News

'Remarkable' Findings From Da Qing Diabetes Prevention Trial

Mon, 10 Jun 2019 11:19:36 +0000

Delaying diabetes by 6 years in this study further reinforces "the thesis that the longer the progression to diabetes can be delayed, the fewer the complications," say Chinese researchers.
Medscape Medical News

AI Not Quite Ready to Make the Call on Stroke Imaging

Mon, 10 Jun 2019 10:22:30 +0000

'Natural intelligence' — that is, physician interpretation — still comes out ahead of artificial intelligence for stroke imaging, although enhanced versions of AI software are on the horizon.
Medscape Medical News

Tropical Skin Conditions on the Rise, Difficult to Detect

Mon, 10 Jun 2019 10:41:08 +0000

As climate change expands the range of ticks and mosquitoes, care teams are encountering unfamiliar tropical diseases, say specialists who will present at the upcoming World Congress of Dermatology.
Medscape Medical News

Flip of the Coin for New-Onset AFib With TAVR or SAVR

Mon, 10 Jun 2019 10:51:40 +0000

Rates of new-onset atrial fibrillation in a National Inpatient Sample analysis are surprisingly high and linked to marked increases in in-hospital mortality.
Medscape Medical News

AMA Backs Innovative Residency Projects With $14.4M in Grants

Mon, 10 Jun 2019 07:01:55 +0000

The projects, which are proposed by institutions in charge of graduate medical education, are intended to 'drive the future of medicine.'
Medscape Medical News

«Наша цель – импортоопережение»

Mon, 10 Jun 2019 10:29:27 +0000

В Петербурге завершился I Всероссийский Фармпробег – масштабное мероприятие, участники которого постарались поднять все основные проблемы отрасли: от низкой доступности качественных лекарств до сложностей с выводом на рынок новых препаратов.

Jury Still Out on Best Settings, Duration of Ultrasound Treatment for Chronic Joint Pain

Sat, 08 Jun 2019 01:05:08 +0000

It is still too early to make definite recommendations on the settings or duration of therapeutic ultrasound for chronic pain in the knee, hip or shoulder, the authors of a systematic review say.
Reuters Health Information

'Congestion' Means Different Things to Doctors and Patients

Sat, 08 Jun 2019 01:06:58 +0000

Patients who say they're "congested" may have a runny nose, but a new study suggests their doctors may think they mean their nose feels blocked and treat them for the wrong symptoms.
Reuters Health Information

Stay Off the Weed, Canada Tells Flight Controllers and Crews

Sat, 08 Jun 2019 01:12:40 +0000

Canadian airlines and flight crews are forbidden to consume cannabis for at least 28 days before going on duty, the country's transportation regulator said on Thursday.
Reuters Health Information

One in Four Ebola Cases Undetected in Congo - WHO

Sat, 08 Jun 2019 01:13:18 +0000

Roughly a quarter of Ebola infections in eastern Congo are estimated to be going undetected or found too late, a World Health Organization (WHO) expert said on Thursday.
Reuters Health Information

U.S. Finds American Guilty in Singapore HIV Data Leak Case

Sat, 08 Jun 2019 01:20:42 +0000

A U.S. citizen who leaked the names of more than 14,000 HIV-positive people in Singapore has been found guilty by a U.S. court of illegally transferring personal data and threatening the Singapore government, court filings show.
Reuters Health Information

Will Europe's Clampdown on Faulty Medical Devices Hurt Patients?

Sat, 08 Jun 2019 01:21:00 +0000

When a Californian company founded by a U.S. veteran wounded in Afghanistan sought to register a new medical device this year, it turned to Europe before the United States. The European approvals system had long been quicker, the company said, but the introduction of new rules is changing all that.
Reuters Health Information

Seizures of Cocaine in Europe Hit Record Amount - EU Drugs Agency

Sat, 08 Jun 2019 01:28:44 +0000

The amount of cocaine seized by authorities in Europe doubled in 2017 to reach a record 140 tonnes in a strong indication of soaring mass supply of the drug coming from Latin America, the Lisbon-based EU drugs agency said on Thursday.
Reuters Health Information

Insys to Pay $225 Mln, Plead Guilty in U.S. Over Opioid Kickbacks

Sat, 08 Jun 2019 01:29:25 +0000

Insys Therapeutics Inc agreed to pay $225 million and an operating unit will plead guilty to fraud to settle probes into their payment of kickbacks to induce doctors to prescribe highly addictive opioids, the U.S. Department of Justice said on Wednesday.
Reuters Health Information

Liraglutide Preserves Beta-Cell Function in New Type 1 Diabetes

Sun, 09 Jun 2019 14:10:33 +0000

Patients with newly diagnosed type 1 diabetes put on liraglutide, in addition to insulin, show greater preservation of insulin production 1 year after diagnosis in an intriguing, although small, study.
Medscape Medical News

'Mix and Match' Options Emerging in Automated Insulin Delivery

Sun, 09 Jun 2019 12:57:26 +0000

In the pursuit of fully automated "closed-loop" insulin delivery systems, organizations and manufacturers are teaming up to allow for interchangeability among devices.
Medscape Medical News

Terrifying Complications in 20 Year Olds With Type 2 Diabetes

Sun, 09 Jun 2019 11:19:08 +0000

"I think we need to recognize that...in these younger kids we probably need even more aggressive management than many adults with type 2 diabetes," says the lead author of the TODAY-2 study.
Medscape Medical News

Endocrinologists Need to Listen to DiRECT Trial Message

Sat, 08 Jun 2019 18:28:50 +0000

The message given to patients with type 2 diabetes 'has got to be trashed', at least for some patients who can lose weight on a liquid diet and reverse their diabetes, says an author of the DiRECT trial.
Medscape Medical News

Implementing ACP Diabetes Guidelines Could Be Cost-Effective

Sat, 08 Jun 2019 17:19:12 +0000

Analysis finds that the American College of Physicians' controversial 2018 recommendations would be cost-effective if applied to the US population with type 2 diabetes.
Medscape Medical News

More Anti-Obesity Drugs for Teens Coming, Devices Are Next Step

Sat, 08 Jun 2019 11:41:38 +0000

For obese teens who are unable to make lifestyle changes and are not candidates for bariatric surgery, there is "hope on the horizon" in the form of medical therapies and endoscopic devices.
Medscape Medical News

D2d: Vitamin D Doesn't Stop Diabetes in Those With Prediabetes

Fri, 07 Jun 2019 20:58:00 +0000

Giving vitamin D to people with prediabetes but mostly without vitamin D insufficiency does not reduce the risk for progression to diabetes, shows D2d, a randomized, controlled trial.
Medscape Medical News

Doctors Caught in Middle of Battle Over Interoperability Rules

Fri, 07 Jun 2019 18:06:34 +0000

MGMA warned regulators not to push physician practices 'too far, too fast.'
Medscape Medical News

Pharmacy School Dean Withdraws From New Role After Retracted Book Review

Fri, 07 Jun 2019 18:07:17 +0000

The Lancet has retracted a book review by the dean of a Canadian school of pharmacy, and the dean has withdrawn from a new appointment at the University of Toronto.
Medscape Medical News

FDA Clears First Soft Robotic Exo-Suit for Stroke Rehab

Fri, 07 Jun 2019 16:54:55 +0000

The ReStore system is designed like a garment that connects to waist pack and cables that help lift the patient's affected leg in synchronized timing with their natural walking pattern.

Medicaid Expansion Linked to Lower CV Mortality

Fri, 07 Jun 2019 17:17:28 +0000

Cardiovascular deaths have remained stable in US states that adopted the Medicaid expansion but have risen in those that didn't agree to the expanded insurance, a new study suggests.
Medscape Medical News

FDA Clears First Device for IBS Pain Relief in Teens

Fri, 07 Jun 2019 17:31:12 +0000

The IB-Stim uses a small electrical nerve stimulator to help reduce functional abdominal pain in patients aged 11 to 18 years with IBS.
FDA Approvals

Early Next-Gen MitraClip Results Impress, Raise Eyebrows

Fri, 07 Jun 2019 15:55:54 +0000

The longer-armed device reduced mitral regurgitation, but single-leaflet device attachment and leaflet injuries during the procedure may signal more selective use, the authors say.
Medscape Medical News

Avoid Fingersticks for Diabetes Dosing Decisions With Eversense

Fri, 07 Jun 2019 15:09:58 +0000

Eversense, Senseonics' long-term implantable continuous glucose monitor, can now be used "nonadjunctively" so that patients don't need to do fingersticks for insulin dosing decisions.
FDA Approvals

Direct-Acting Antivirals in HCV: Low Risk for Adverse Events

Fri, 07 Jun 2019 15:21:09 +0000

In a nationally representative sample, patients taking direct-acting antivirals for chronic HCV infection did not experience higher rates of treatment-related adverse events than patients not taking the drugs.
Medscape Medical News

Oncologists Are Engaging Less With Industry Since Open Payments

Fri, 07 Jun 2019 14:28:15 +0000

Fewer oncologists are receiving industry payments since the inception of the Open Payments program, but spending has not decreased and appears to have shifted.
Medscape Medical News

Discovery Could Herald 'Game Changer' for Hyperparathyroidism

Fri, 07 Jun 2019 14:33:26 +0000

Discovery of a signaling protein in mice, which could ultimately lead to development of a drug, "is a potential game changer in the [future] treatment of hyperparathyroidism," says an expert.
Medscape Medical News

Bictegravir-Based Regimen Noninferior to Dolutegravir-Based Regimens for HIV Treatment

Fri, 07 Jun 2019 11:22:02 +0000

A single-tablet regimen of bictegravir, emtricitabine and tenofovir alafenamide is noninferior to regimens of dolutegravir coformulated with emtricitabine and tenofovir alafenamide or with abacavir and lamivudine for the initial treatment of HIV-1 infection, according to results from two randomized phase 3 trials.
Reuters Health Information

Long-Standing AF Tied to Outcomes of Left-Atrial-Appendage Occlusion

Fri, 07 Jun 2019 11:21:49 +0000

Long-standing persistent atrial fibrillation (LSPAF) is associated with more residual leak following percutaneous left atrial appendage (LAA) occlusion with the Watchman device, according to one of two new studies of LAA closure.
Reuters Health Information

International Travelers' Lung Health Impacted in Polluted Cities

Fri, 07 Jun 2019 12:22:42 +0000

When healthy international travelers visit a city with higher levels of particle pollution than at home, their heart and lung function quickly deteriorate, a small study suggests.
Reuters Health Information

App Helps People Learn to Meditate, Improves Attention Skills

Fri, 07 Jun 2019 12:25:20 +0000

An experimental app may help people learn to meditate, which in turn yields improvements in attention span and working memory, a new study suggests.
Reuters Health Information

Young Adults See Less Harm in Tobacco Products, Prefer Online Health Information

Fri, 07 Jun 2019 12:14:15 +0000

Young adults may be more likely than older folks to go online to find health information, and less likely to view tobacco products as "very harmful," according to survey results compiled to inform U.S. Food and Drug Administration (FDA) regulatory policy.
Reuters Health Information

Topical Calcineurin Inhibitors Effective for Vitiligo as Monotherapy or With Phototherapy

Fri, 07 Jun 2019 12:14:09 +0000

Patients with vitiligo can be safely and effectively treated with topical calcineurin inhibitors (TCIs), with or without phototherapy, say authors of a systematic review and meta-analysis.
Reuters Health Information

Democrats Plan Event to Scrutinize Trump's Mental Health

Fri, 07 Jun 2019 11:00:45 +0000

A Democratic congressman is considering convening a town hall-like event sometime this summer to discuss Donald J. Trump's mental fitness to serve as president.
Medscape Medical News

Novel Med May Curb Obsessions in Binge Eating Disorder

Fri, 07 Jun 2019 12:20:32 +0000

The novel dopamine/norepinephrine reuptake inhibitor dasotraline reduces number of binge-eating days, as well as obsessions and compulsions, for patients with binge eating disorder, new research suggests.
Medscape Medical News

Under Right Circumstances, Bariatric Surgery Good for Obese Teens

Fri, 07 Jun 2019 12:37:29 +0000

"The objective evidence shows that, under the right circumstances and with the right patients, bariatric surgery is an effective treatment for adolescents with obesity," says the lead author of a new review.
Medscape Medical News

ВОЗ бьет тревогу по поводу инфекций, передающихся половым путем

Fri, 07 Jun 2019 16:57:39 +0000

Всемирная организация здравоохранения призвала к более открытому обсуждению инфекций, передаваемых половым путем (ИППП). По данным ВОЗ, опубликованным онлайн, ежегодно регистрируется 376 миллионов (более 1 миллиона в день) случаев заражения четырьмя заболеваниями: хламидиозом, гонореей, сифилисом и трихомониазом.

Medical Assistance in Dying and Organ Donation Should Be Separate Decisions

Fri, 07 Jun 2019 10:29:01 +0000

The decisions to seek medical assistance in dying (MAiD) and to offer organs and tissues for transplant should be separate, according to guidelines proposed by Canadian organizations.
Reuters Health Information

Burnout Inclusion in ICD-11: Media Got It Wrong, WHO Says

Fri, 07 Jun 2019 10:48:55 +0000

Contrary to multiple media reports, burnout has not been recognized by the World Health Organization as a disease, but rather an occupational factor influencing health status.
Medscape Medical News

[World Report] HIV epidemic in children in Pakistan raises concern

Fri, 07 Jun 2019 14:00:07 +0000

The epidemic could be found to have reached adults as well. Experts suspect that it is a marker of systematic failures in health-care provision. Andrew Green reports.

В Калужской области будет создан центр протонной терапии

Fri, 07 Jun 2019 16:33:12 +0000

Соглашение об этом было подписано между ФГБУ «НМИЦ радиологии», холдингом «Росэлектроника» Госкорпорации Ростех и чешской компанией Proton Therapy Development s.r.o. в ходе ПМЭФ-2019. Первых пациентов будущий центр сможет принять через пять лет. А с 2020 года в России этот метод войдет в программу высокотехнологичной медицинской помощи, финансируемой из средств ОМС.

Middle Schools Can Help Prevent Teen Dating Violence

Fri, 07 Jun 2019 01:33:36 +0000

Middle schools that offer a comprehensive dating violence prevention program in every grade may have fewer youth involved in abusive relationships, a U.S. study suggests.
Reuters Health Information

U.S. Soldiers Have Worse Heart Health Than Civilians

Fri, 07 Jun 2019 01:37:16 +0000

U.S. soldiers are more likely to have poor heart health than civilians of similar ages, a new study finds.
Reuters Health Information

Система ОМС заработала по новым правилам

Fri, 07 Jun 2019 07:46:27 +0000

В конце мая вступили в силу новые правила обязательного медицинского страхования. В документе прописан пошаговый регламент сопровождения пациентов на всех этапах лечения. Страховые компании будут контролировать оказание медпомощи и диспансерное наблюдение, информировать пациентов о положенном им лечении и штрафовать больницы в случае назначения нерациональной фармакотерапии.

Number of US Measles Cases Tops 1000 for First Time Since 1992

Thu, 06 Jun 2019 19:22:49 +0000

There have been 1001 new cases of measles in the United States since January 1, according to a June 5 statement from Health & Human Services Secretary Alex Azar.
Medscape Medical News

[Review] Novel paradigms in systemic lupus erythematosus

Thu, 06 Jun 2019 23:00:09 +0000

The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is now challenging the entire lupus community, from geneticists to clinical investigators. Although the outlook for patients with SLE has greatly improved, many unmet needs remain, chief of which is the development of safer and more efficacious therapies. To develop innovative therapies, a far better understanding of SLE pathogenesis as it relates to the array of clinical phenotypes is needed. Additionally, to efficiently achieve these goals, the lupus community needs to refine existing clinical research tools and better adapt them to overcome the obstacles created by the heterogeneity of manifestations.

[Seminar] Management strategies and future directions for systemic lupus erythematosus in adults

Thu, 06 Jun 2019 23:00:09 +0000

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of self-tolerance and formation of nuclear autoantigens and immune complexes resulting in inflammation of multiple organs. The clinical presentation of SLE is heterogeneous, can involve one or more organs, including the skin, kidneys, joints, and nervous system, and take a chronic or relapsing and remitting disease course. SLE is most common in women and in those of non-white ethnicity. Because of the multitude of presentations, manifestations, and serological abnormalities in patients with SLE, diagnosis can be challenging.

[Clinical Picture] Tetanus: remember to vaccinate

Thu, 06 Jun 2019 23:00:09 +0000

An 80-year-old Japanese man attended our hospital with a 3-day history of stiffness in his jaw and difficulty moving his right arm. He had no history of ever travelling abroad, but he did have a medical history of hypertension, osteoporosis, and total gastrectomy due to gastric carcinoma. He told us that he had hurt his right hand while working in his garden 10 days ago. On physical examination, we found him to have a stiff neck, trismus, and a fixed sardonic-type smile (figure). Additionally, his abdomen was board-like rigid, and there was muscle rigidity and increased tone in his arms and legs.

[Articles] Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel-arm, non-inferiority trial

Thu, 06 Jun 2019 23:00:09 +0000

Suboptimal pain reduction in patients with gallstones and abdominal pain was noted with both usual care and following a restrictive strategy for selection for cholecystectomy. However, the restrictive strategy was associated with fewer cholecystectomies. The findings should encourage physicians involved in the care of patients with gallstones to rethink cholecystectomy, and to be more careful in advising a surgical approach in patients with gallstones and abdominal symptoms.

[Articles] Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial

Thu, 06 Jun 2019 23:00:09 +0000

In medical inpatients at nutritional risk, the use of individualised nutritional support during the hospital stay improved important clinical outcomes, including survival, compared with standard hospital food. These findings strongly support the concept of systematically screening medical inpatients on hospital admission regarding nutritional risk, independent of their medical condition, followed by a nutritional assessment and introduction of individualised nutritional support in patients at risk.

[Articles] Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study

Thu, 06 Jun 2019 23:00:09 +0000

Upadacitinib monotherapy showed statistically significant improvements in clinical and functional outcomes versus continuing methotrexate in this methotrexate inadequate-responder population. Safety observations were similar to those in previous upadacitinib rheumatoid arthritis studies.

[Correspondence] Neglect of menarche and menstruation in the USA

Thu, 06 Jun 2019 23:00:09 +0000

Aaron van Dorn1 recently discussed the America's Children in Brief report and the complexities of child poverty and health care in the USA.2 Although appreciating improvement in some key child health indicators, van Dorn highlighted on-going challenges to improving the health of children growing up in poverty today.

[Correspondence] Genotype–phenotype association in patients with SCN4A mutation – Authors' reply

Thu, 06 Jun 2019 23:00:09 +0000

We are pleased with Ibrahim El-Battrawy and colleagues' interest in our work.1 We note that the authors are concerned that the sodium current recordings in our patch clamp experiments could have been contributed to by NaV1.5. As described in the methods section,1 we assessed expression in HEK293 cells, which do not express endogenous sodium channels. These cells were transfected with mutant and wild-type SCN4A DNA. This approach excludes any possibility of NaV1.5, or any other sodium channel isoform, contributing to the sodium current recordings.

[Correspondence] Genotype–phenotype association in patients with SCN4A mutation

Thu, 06 Jun 2019 23:00:09 +0000

Roope Männikkö and colleagues1 described an association between dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, and sudden infant death syndrome (SIDS). The authors found that rare SCN4A variants occurred in infants who died from SIDS. Patch clamp studies presented an alteration of sodium channel kinetics.

[Correspondence] Refugee and migrant health in the European Region

Thu, 06 Jun 2019 23:00:09 +0000

WHO is the respected authority in leading the production and use of core evidence for public health decision making.1 The Health Evidence Network (HEN) is an information service for public health decision makers in the WHO European Region and supports them to use the best available evidence. The Migration and Health Programme at the Regional Office was established as the first WHO programme wholly focusing on refugee and migrant health and operates on the basis of four pillars, one of which focuses on health information, research, and training.

[Correspondence] Immigration in Italy: the medical community's role in human rights

Thu, 06 Jun 2019 23:00:08 +0000

Italy has been witnessing a rapid escalation towards racism and xenophobia since the new government came into power in June, 2018. On Nov 27, 2018, the lower house of the Italian Parliament approved the Decree-Law on Immigration and Security, which includes measures that would abolish humanitarian protection status for migrants, block asylum seekers from accessing reception centres focusing on social inclusion, and extend the duration of detention in return centres and hotspots. These measures fundamentally undermine international human rights principles.

[Correspondence] Privatisation of immigration detention facilities

Thu, 06 Jun 2019 23:00:08 +0000

In December, 2018, two Guatemalan children, a 7-year-old girl and an 8-year-old boy, died while detained in immigration custody in the USA. Their tragic deaths should raise alarm about the dangerously substandard medical and mental health care at US immigration detention facilities.

[Correspondence] Health of migrants: simple questions can improve care – Authors' reply

Thu, 06 Jun 2019 23:00:08 +0000

We thank Baltica Cabieses for describing the importance of simple innovation in addressing some of the challenges reported in the UCL–Lancet Commission on Migration and Health,b particularly regarding clinical consultations and the operationalisation of care pathways for migrants. The examples cited are consistent with the approach proposed in the Commission report and with the Commission's recommendation about implementing evidence-based health interventions, alongside analysis of effect and effectiveness.

[Correspondence] Health of migrants: simple questions can improve care

Thu, 06 Jun 2019 23:00:08 +0000

The UCL–Lancet Commission on Migration and Health by Ibrahim Abubakar and colleagues1 was dedicated to the complex relation between international migration and population health. This Commission updated the discussion on this complex relationship and illustrated, with real-world evidence, the positive effect of migration above and beyond possible limitations and pervasive myths.2,3

[Correspondence] Inequality, world health, and global governance

Thu, 06 Jun 2019 23:00:08 +0000

Richard Horton1 correctly states that good health depends on political, economic, and social forces that shape conditions of living. To address health care on a global scale, immediate and comprehensive efforts both on an international and national level have to be realised. The most imminent and relevant global issue that is closely linked to world health is probably climate change.2 Climate change has direct negative local effects (eg, droughts, flooding, and famine) and supraregional repercussions (eg, migration).

[Obituary] Richard Valery Mouzoko Kiboung

Thu, 06 Jun 2019 23:00:08 +0000

Public health physician, epidemiologist and front-line responder to Ebola outbreak. Born in Bafia, Cameroon, on May 31, 1977, he was killed during an attack on Butembo University Hospital in DR Congo on April 19, 2019, aged 41 years.

[Perspectives] Medical misinformation and the internet: a call to arms

Thu, 06 Jun 2019 23:00:08 +0000

Almost 16 years ago my family and I were deposited on the other side of the stethoscope. Pregnant with triplets, my membranes ruptured at almost 23 weeks and I delivered my first son who I elected not to resuscitate. I managed to stay pregnant until 26 weeks when I developed chorioamnionitis and delivery was required. My sons Oliver and Victor had a long road out of the neonatal intensive-care unit. They both had bronchopulmonary dysplasia. Oliver also had a cardiac defect unrelated to prematurity that needed surgery, and Victor had cerebral palsy.

[Perspectives] Katja Iversen: driving force in women's health and gender equity

Thu, 06 Jun 2019 23:00:08 +0000

It was probably a combination of insight, cheekiness, and outstanding communication skills that made Katja Iversen so persuasive when she spoke to world leaders at last year's G7 meeting in Charlevoix, Canada, on behalf of the first ever G7 Gender Equality Advisory Council. “I presented recommendations on a range of topics in health and education, including the areas of safe abortion and sexual and gender-based violence. It became a very lively, engaged hour of discussion”, says Iversen, who is President and Chief Executive Officer (CEO) of Women Deliver.

[Perspectives] Opening the box of tricks

Thu, 06 Jun 2019 23:00:08 +0000

The human capacity for credulity seems boundless. Smoke and Mirrors: The Psychology of Magic, an exhibition at Wellcome Collection, London, UK, shows how magicians, mediums, and other tricksters have exploited people's willingness to believe the improbable and accept the impossible for centuries. Curators Honor Beddard and A R Hopwood have selected a fascinating array of material from various sources—from the British Library to the Magic Circle—to lift the lid on the tools and tricks used to create illusion and distort truth from Victorian times to the present day.

[Perspectives] Personal space

Thu, 06 Jun 2019 23:00:08 +0000

I used to ride a scooter in London. One warm summer's evening I was riding home, visor up, when some boys on the pavement threw a water bomb that hit me in the face. My eye was painful and my vision blurred so I went to my local eye hospital. I was examined by an ophthalmology trainee who seemed very nervous. He didn't say a word but loomed over me, stuck an ophthalmoscope in my face, shone bright lights in my eye, and went away. A while later, I was seen by the consultant. Things couldn't have been more different.

[World Report] AMLO's Mexico leads to drastic cuts to health system

Thu, 06 Jun 2019 23:00:08 +0000

The anti-corruption president has set some stringent targets for the health system—critics worry that these are brash and could be damaging to the system. David Agren reports.

[World Report] HIV epidemic in children in Pakistan raises concern

Thu, 06 Jun 2019 23:00:08 +0000

The so-called epidemic could be found to have reached adults as well. Experts suspect that it is a marker of systematic failures in health-care provision. Andrew Green reports.

[World Report] UK, Germany, dissociate from WHO drug pricing resolution

Thu, 06 Jun 2019 23:00:08 +0000

The passage of a landmark resolution on improving the transparency of markets for medicines at the latest WHA fails to narrow the political divide. John Zarocostas reports from Geneva.

[Comment] Offline: Young people—from listening to leadership

Thu, 06 Jun 2019 23:00:08 +0000

The hypocrisy of global health can be suffocating. Writing in their 2016 Lancet Commission on Adolescent Health and Wellbeing, George Patton and colleagues argued for the “establishment of forums for meaningful youth participation”. Such forums should strengthen “mechanisms for the meaningful participation of adolescents in the design, communication, and implementation and monitoring of policies and practices that affect their health and wellbeing. This is particularly important for socially and economically marginalised adolescents”.

[Comment] Fresh focus on health: Highlights 2019 photography competition open for submissions

Thu, 06 Jun 2019 23:00:08 +0000

Photographs are a powerful way to convey health stories. Earlier this year, The Lancet published a photo feature about a new face for leprosy. These pictures captured moments of humanity and showed patients with leprosy enjoying life, function, and community, in ways that were a departure from conventional pictures of disability. We are looking for equally arresting images for Highlights 2019.

[Comment] The Wakley Prize Essay 2019: getting better

Thu, 06 Jun 2019 23:00:08 +0000

“I've got to admit it's getting better / A little better all the time”, sang Paul McCartney; “It can't get no worse” was John Lennon's rejoinder on backing vocals. Medicine, like the music of the Beatles, balances sunshine and shadows. We hear a lot about the misery of modern medicine—short-term agendas, increasing consumerism, high workloads, burnout, fragmentation, insufficient resources, too little time for patients or research. But what about the sunshine? What excites you, fires your commitment, keeps you in the profession, makes change possible, brings moments of transformation or understanding? What are the rewards, pleasures, or surprises of the practice of medicine? Let us know by writing an essay for The Lancet's annual essay competition, the Wakley Prize.

[Comment] Health care: conflicted, confused, and in need of change

Thu, 06 Jun 2019 23:00:08 +0000

Conflicts of interest in medicine are a serious, pervasive issue. Yet there is insufficient leadership and resolve within global institutions to adequately address this issue. We are concerned with how to ensure transparency of interests and what conflicts of interest should be allowed even if fully disclosed. The second question remains moot while the first remains unsolved, and this is what we discuss here.

[Comment] Pain after cholecystectomy for symptomatic gallstones

Thu, 06 Jun 2019 23:00:07 +0000

Around 20% of adults in the western world have gallstones1 but only one in five patients with gallstones ever develops symptoms.1 Because patients with abdominal pain present frequently to general practitioners or to specialist care and often receive a scan,2,3 finding gallstones or sludge during work-up has a high a priori likelihood and they are easily attributed as a cause of the symptoms. The ready access and preference for cholecystectomy in patients with symptomatic, uncomplicated gallstones has made cholecystectomy the most frequently done procedure in general surgery,4 with more than 900 000 annual procedures done in the USA alone.

[Comment] Improving outcomes with a little EFFORT

Thu, 06 Jun 2019 23:00:07 +0000

The adverse effect of excessive weight loss on clinical outcomes was documented over 80 years ago when Hiram Studley1 showed that, in patients undergoing surgery for perforated duodenal ulcer, postoperative mortality was ten times greater in those who had lost more than 20% of their bodyweight preoperatively, compared with those who had lost less. Similarly, less pronounced results were shown in medical (not undergoing surgical treatment) patients. The potential importance of these observations was emphasised by a study from the 1990s showing that 30% of 500 patients admitted to hospital for treatment had moderate-to-severe malnutrition on admission.

[Comment] Novel DMARD monotherapy in rheumatoid arthritis

Thu, 06 Jun 2019 23:00:07 +0000

In The Lancet, Josef Smolen and colleagues1 report the results of a double-blind, placebo-controlled trial of upadacitinib, a new oral Janus kinase (JAK) inhibitor, in patients with active rheumatoid arthritis (RA). Interestingly, upadacitinib was evaluated as a monotherapy, without concomitant methotrexate (MTX). Existing recommendations for management of RA2 do not include novel disease-modifying antirheumatic drug (DMARD) monotherapy as part of the strategy. Nevertheless, there is growing interest in the use of novel DMARDs (namely, biological DMARDs [bDMARDs], such as tumour necrosis factor-α or interleukin-6 inhibitors, as well as targeted synthetic DMARDs [tsDMARDs], such as oral JAK inhibitors) in RA monotherapy.

[Editorial] Planetary health in the Anthropocene

Thu, 06 Jun 2019 23:00:07 +0000

In May, 29 of 34 members of the Anthropocene Working Group voted to recognise the Anthropocene as the geological epoch entered in the 20th century, characterised by human activity rapidly shaping our planet. Human impact extends beyond geological labelling, affecting all forms of life. Human progress includes multiple successes but has also led to immense pressure on the planetary systems on which we depend, affecting human health through an unfolding climate emergency, human-made air pollution, and broken unsustainable food systems.

[Editorial] Plan S: the final cut

Thu, 06 Jun 2019 23:00:07 +0000

A consortium of research funders, Coalition S, has published its revised recommendations for accelerating the transition to open access for scientific publications. The fundamental principles of Plan S remain intact. No scholarly publication should be locked behind a paywall. Open access should be immediate, without embargoes. The preferred Creative Commons licence is CC BY. Funders will support open access fees at reasonable levels. Funders will not pay for publication in hybrid journals, unless they are part of transformative arrangements with clearly defined open access endpoints.

[Editorial] ICD-11

Thu, 06 Jun 2019 23:00:07 +0000

The International Classification of Diseases (ICD) is a health statistics coding tool that aims to describe an entity that is challenging to quantify and even more problematic to standardise—the human condition. The history of ICD dates back to 16th century England where deaths from distinctly medieval causes (scurvy, leprosy, and plague) were announced by the London Bills of Mortality on a weekly basis.

'Scary World' of Generic Drug Manufacturing, Revealed

Thu, 06 Jun 2019 17:57:45 +0000

Doctors noticed problems with the generic drugs their patients took and helped investigative reporter Katherine Eban bring to light systemic issues with the drugs' manufacturing and regulation.
Medscape Medical News

No Survival Benefit With Immunotherapy in TN Breast Cancer

Thu, 06 Jun 2019 18:17:11 +0000

The "modest" improvement in progression-free survival means that atezolizumab is "certainly reasonable" as a first-line therapy in metastatic patients, says Cesar Santa-Maria, Northwestern University.
Medscape Medical News

FDA OKs Two Self-Administered Options for Mepolizumab (Nucala)

Thu, 06 Jun 2019 18:39:36 +0000

In addition to mepolizumab subcutaneous injection given by a health provider, the drug will also be available as an autoinjector and prefilled safety syringe for at-home use.
FDA Approvals

Almost 400M New Cases Annually of Four Curable STIs, WHO Says

Thu, 06 Jun 2019 16:54:49 +0000

Globally, more than 1 million people contract a curable sexually transmitted infection each day, amounting to more than 376 million new cases annually of chlamydia, gonorrhoea, trichomoniasis, and syphilis.
Medscape Medical News

Средний человек съедает около 50000 частиц микропластика в год

Thu, 06 Jun 2019 22:59:49 +0000

Человек в среднем съедает не менее 50000 частиц микропластика в год и такое же количество вдыхает, говорит первое в своем роде исследование. Возможно, реальное количество окажется даже большим, так как ученые анализировали на предмет загрязнения пластиком лишь небольшое количество продуктов питания и напитков.

Пищевые расстройства у мальчиков: мышцы, стероиды, биодобавки

Thu, 06 Jun 2019 23:08:35 +0000

Многие родители и педиатры ошибочно полагают, что мальчики-подростки не склонны к расстройствам пищевого поведения, поскольку их симптомы отличаются от тех, которые обычно наблюдаются у девочек.

Emollients Fail to Protect Against Eczema

Thu, 06 Jun 2019 15:55:37 +0000

Results from two large clinical trials have dermatologists debating the value of creams for preventing or delaying eczema and questioning the next steps in clinical practice.
Medscape Medical News

Less Toxicity With Proton Beam vs Photon Chemoradiotherapy

Thu, 06 Jun 2019 15:58:35 +0000

Survival outcomes were similar compared with traditional photon chemoradiotherapy, but patients treated with proton beam therapy had significantly fewer serious adverse events.
Medscape Medical News

Diamonds Are Forever, but TKIs in CML Don't Have to Be

Thu, 06 Jun 2019 16:17:52 +0000

Patients with chronic myeloid leukemia who undergo lifelong therapy with tyrosine kinase inhibitors have excellent outcomes. But treatment may not have to be forever.
Medscape Medical News

Novel OCT-based FFR Technique Saves a Step in PCI

Thu, 06 Jun 2019 16:26:59 +0000

The technique combines optical coherence tomography and fractional flow reserve to give structural and hemodynamic information in a single pullback.
Medscape Medical News

Doctor Accused of Disparaging Employer Wins Court Ruling

Thu, 06 Jun 2019 16:34:04 +0000

A Pennsylvania court ruled that a fired endocrinologist is eligible for unemployment benefits after his former employer failed to provide "competent, first-hand evidence" of the alleged remarks.
Medscape Medical News

Best Pain Management Practices Outlined in New HHS Report

Thu, 06 Jun 2019 16:45:32 +0000

The Pain Management Task Force of HHS released its final report on best practices in pain management, emphasizing a patient-centered, balanced, individualized approach.
Medscape Medical News

Serial-Killer Nurse Jailed for Life in Germany

Thu, 06 Jun 2019 15:14:12 +0000

A former nurse was jailed for life on Thursday for murdering 85 of his patients - the worst killing spree in Germany's post-war history.
Reuters Health Information

HIT Workout Helps MS Patients Reach New Highs

Thu, 06 Jun 2019 14:58:51 +0000

High-intensity interval training, the repetition of high-intensity exercises combined with strategically timed recovery, shows improvements in patients with mild symptoms.
Medscape Medical News

Undiagnosed FH Linked to 16-Year Life Expectancy Reduction

Thu, 06 Jun 2019 15:27:03 +0000

The high premature cardiovascular death risk in undiagnosed familial hypercholesterolemia (FH) supports the case for earlier cholesterol screening, investigators say.
Medscape Medical News

Psychiatrists' Acceptance of Medicaid Patients Remains Low

Thu, 06 Jun 2019 11:57:42 +0000

Medicaid expansion has done nothing to ease the problem of access to mental health services because few psychiatrists take Medicaid patients.
Medscape Medical News

Genetic Testing May Help Identify Best Antidepressant

Thu, 06 Jun 2019 12:43:32 +0000

Pharmacogenomic testing may help clinicians choose the most appropriate antidepressant and improve patients' chances of achieving remission or response.
Medscape Medical News

Выгорание и загруженность на работе приводят к нездоровым привычкам и набору веса

Thu, 06 Jun 2019 08:33:19 +0000

Чувство переутомления способствует различным нездоровым привычкам, которые могут привести к увеличению веса, как показало новое исследование Университета Джорджии, опубликованное в Journal of Health Psychology. Согласно полученным результатам, стресс от работы негативно сказывается на способности выбирать необходимые стратегии для поддержания здорового веса.

VADT at 15 Years Published: Lack of 'Legacy Effect' in Diabetes

Wed, 05 Jun 2019 17:03:04 +0000

Newly published results highlight the differing impact of intensive glycemic control on those with newly diagnosed versus long-term diabetes with established CVD, and the importance of other risk factors.
Medscape Medical News

U.S. Health Agency Cancels Research Contract Involving Use of Fetal Tissue

Wed, 05 Jun 2019 17:17:07 +0000

The Department of Health and Human Services (HHS) said on Wednesday it would cancel its research contract involving human fetal tissue from elective abortions with the University of California.
Reuters Health Information

Some Dietary Supplements Tied to Severe Outcomes in Youth

Wed, 05 Jun 2019 16:02:39 +0000

Dietary supplements sold for weight loss, muscle building, and energy are tied to severe adverse events in youth; researchers call for better regulation and decreased access to supplements by youth.
Medscape Medical News

Exercise Activates Memory in Seniors

Wed, 05 Jun 2019 16:44:05 +0000

A single 30-minute workout of moderately intense exercise stimulates memory networks in the brains of healthy, older adults, new research shows.
Medscape Medical News

Novel Per-conditioning Strategy Disappoints in Stroke

Wed, 05 Jun 2019 14:28:10 +0000

The concept of inducing transient ischemia in a different part of the body in an attempt to protect the brain from the larger ischemic insult of a stroke was not successful in the RESCUE BRAIN study.
Medscape Medical News

Judge Weighs Fate of Missouri's Only Abortion Clinic After Court Hearing

Wed, 05 Jun 2019 13:34:57 +0000

A St. Louis judge said on Tuesday he will work quickly to decide whether Missouri's only abortion clinic can remain open after a hearing on a lawsuit aimed at forcing state health officials to renew the facility's license to perform the procedure.
Reuters Health Information

Sanofi Loses German Patent Case Against Amgen Over Cholesterol Drug

Wed, 05 Jun 2019 13:15:33 +0000

Germany's highest civil court on Tuesday rejected French drugmaker Sanofi's bid to fend off a legal challenge by U.S. rival Amgen against Sanofi's cholesterol drug Praluent.
Reuters Health Information

Большая жировая масса тела резко увеличивает риск смерти после операции на сердце

Wed, 05 Jun 2019 18:31:29 +0000

Согласно новому исследованию, проведенному французским врачом Ксавье Леруа из отделения анестезии и реанимации Медицинского центра Университета Лилля вместе с коллегами, смертность у пациентов с большой жировой массой тела, перенесших операцию по шунтированию сердца, более чем в четыре раза выше.

Hallucinations May Point to Rare, Non-Psychotic Condition

Wed, 05 Jun 2019 12:16:56 +0000

Charles Bonnet syndrome is relatively rare, but due to the aging population, cases may be increasing. Clinicians need to be able to distinguish its hallucinatory symptoms from those of psychosis.
Medscape Medical News

Are Patients Consumers?

Wed, 05 Jun 2019 12:18:43 +0000

Some experts suggest that the language we use to talk about the medical experience must change.
Medscape Reader Polls

Большая жировая масса тела резко увеличивает риск смерти после операции на сердце

Wed, 05 Jun 2019 18:31:29 +0000

Согласно новому исследованию, проведенному французским врачом Ксавье Леруа (Xavier Leroy) из отделения анестезии и реаниматологии Медицинского центра Университета Лилля (CHU Lille) вместе с коллегами, смертность у пациентов с большой жировой массой тела, перенесших операцию по шунтированию сердца, более чем в четыре раза выше.

Insomnia Drugs: Some More Dangerous Than Others

Wed, 05 Jun 2019 11:34:32 +0000

The rate of suicide by poisoning, often with sleeping pills, has tripled since 2000, making it essential for clinicians to be aware of the safety of the medications they are prescribing.
Medscape Medical News

UK's MHRA Offers Split Recs on Paclitaxel-Coated Devices in PAD

Wed, 05 Jun 2019 11:45:41 +0000

The agency acted to limit the future use of the devices in routine clinical care of intermittent claudication but left open their use in critical limb ischemia.
News Alerts

New Feline Diet Curbs Allergy to Cats

Wed, 05 Jun 2019 10:30:53 +0000

There is no such thing as a hypoallergenic cat, but researchers have found that felines fed a special diet are less allergenic for people with allergies.
Medscape Medical News

Tracking Late AV Block Post-TAVR With Ambulatory ECG Monitoring

Wed, 05 Jun 2019 09:38:58 +0000

Tapping into technology may help identify at-risk patients and better clarify poorly understood risk factors for this post-TAVR complication.
Medscape Medical News

Preemies and Early Arrivals Have Higher Risk of Heart Disease as Adults

Wed, 05 Jun 2019 08:14:11 +0000

Babies who are born too soon may be more likely to develop heart disease as adults than full-term infants, a new study suggests.
Reuters Health Information

In States With Most Overdose Deaths, Poor Patients Struggle to Find Treatment

Wed, 05 Jun 2019 07:57:00 +0000

Poor people with opioid use disorders may struggle to find doctors to prescribe the anti-addiction drug buprenorphine in U.S. states with the highest overdose death rates, a new study suggests.
Reuters Health Information

Therapy in the Office: Banks Take Mental Health Fight In-House

Wed, 05 Jun 2019 07:13:48 +0000

In 'Billions', a U.S. television show set in the world of hedge funds, traders at the fictional Axe Capital regularly attend sessions with an in-house psychiatrist.
Reuters Health Information

Even Mild Brain Injuries Tied to Lasting Functional Deficits

Wed, 05 Jun 2019 07:25:32 +0000

People who have mild traumatic brain injuries may be more likely to have lasting functional deficits that get in the way of daily activities than patients who experience other types of injuries, a U.S. study suggests.
Reuters Health Information

GERD Reduction Overestimated After Gastric Bypass

Wed, 05 Jun 2019 07:03:51 +0000

Gastric bypass surgery relieved symptoms of gastroesophageal reflux disease in only approximately half of patients with severe obesity, a study found.
Medscape Medical News

Белое и красное мясо одинаково "нагружает" нас холестерином

Wed, 05 Jun 2019 13:23:43 +0000

Вопреки распространенному мнению, на уровень холестерина в крови в равной степени влияет потребление и красного, и белого мяса, согласно исследованию, опубликованному в American Journal of Clinical Nutrition.

Involve Parents in Prenatal Counseling on Extreme Prematurity: Recommendations

Wed, 05 Jun 2019 06:45:24 +0000

Both parents should be involved in prenatal counseling in cases of extreme prematurity, with both the neonatologist and obstetrician, according to new recommendations from an expert panel in the Netherlands.
Reuters Health Information

«Мы фактически выполняем функцию военных хирургов – вернуть раненого в строй»

Wed, 05 Jun 2019 08:38:19 +0000

Лечение онкологических больных с участием пластического хирурга сегодня перестает быть эксклюзивом. О том, как реконструктивно-пластические операции пациентов с тяжелыми деформациями челюстно-лицевой области позволяют восстановить утраченные органы и их работоспособность, рассказал директор Клиники кластерной онкологии Первого МГМУ им. И.М. Сеченова, академик РАН Игорь Решетов.

FDA Obtains Permanent Injunction Against US Stem Cell

Tue, 04 Jun 2019 20:18:00 +0000

A US District Court granted a permanent injunction requiring US Stem Cell Clinic to stop marketing adipose-derived stem cell treatments.
Medscape Medical News

Galcanezumab (Emgality) Gets FDA OK for Cluster Headache

Tue, 04 Jun 2019 19:34:44 +0000

The CGRP antagonist was first approved by the FDA last year for the prevention of migraine in adults.
FDA Approvals

Violent Video Games Linked to Risky Behavior With Real Guns

Tue, 04 Jun 2019 16:57:36 +0000

Kids who played a video game with gun or sword violence were more likely to handle a real (disabled) handgun, handle it longer, and pull the trigger more times than kids who played a nonviolent game.
Medscape Medical News

Is Renal Infarction Linked to Cardiac Amyloidosis?

Tue, 04 Jun 2019 17:03:47 +0000

First study of its kind finds renal infarction in cardiac amyloidosis may be more common than previously thought, especially in patients with acute kidney injury, but an expert questions the results.
Medscape Medical News

Former CDC Chief Frieden Pleads Guilty to Disorderly Conduct

Tue, 04 Jun 2019 17:07:16 +0000

All charges will be dropped and his record will be expunged after a year.
Medscape Medical News

Measles Cases Continue to Rise, Highest Since 1992

Tue, 04 Jun 2019 17:11:44 +0000

Another 41 confirmed cases of measles were reported in the last week, bringing this year's total to 981, according to a report from the Centers for Disease Control and Prevention.
Medscape Medical News

ASTER2: Aspiration Adds Little to Retriever Thrombectomy

Tue, 04 Jun 2019 14:05:06 +0000

After previous research showed no significant difference between contact aspiration and stent retriever for acute cerebral infarction recanalization, investigators explored a combination approach.
Medscape Medical News

Novel Convulsive Therapy May Cut Suicidal Thoughts in BD

Tue, 04 Jun 2019 13:16:12 +0000

Magnetic seizure therapy appears effective in treating severe depression and suicidal thoughts while having a more benign effect on cognitive function than electroconvulsive therapy.
Medscape Medical News

At-Home Video Goggles Provide Early, Accurate Vertigo Diagnosis

Tue, 04 Jun 2019 11:59:43 +0000

Vertigo can be difficult to diagnose because an episode is usually over by the time patients reach the clinic. Video goggles worn at home may enable earlier, more accurate diagnosis.
Medscape Medical News

New Tool Helps Assess Burgeoning Number of Mental Health Apps

Tue, 04 Jun 2019 12:08:56 +0000

With the rapid proliferation of mobile health apps, the American Psychiatric Association has relaunched its app evaluation tool in a bid to help clinicians navigate this often confusing landscape.
Medscape Medical News

Too Many CKD Patients Get Central Catheters Despite Warnings

Tue, 04 Jun 2019 11:44:35 +0000

Almost one quarter of patients with advanced CKD receive a peripherally inserted central catheter while in hospital, despite their relative contraindication, in order to preserve future vascular access.
Medscape Medical News

Действительно ли для сохранения здоровья нужно делать 10000 шагов в день?

Tue, 04 Jun 2019 17:19:33 +0000

С момента появления разнообразных устройств для отслеживания количества шагов, многие люди стали стремиться делать не менее 10000 шагов в день и волноваться, если этой цели не удается достигнуть. Новое исследование, проведенное Гарвардской медицинской школой, говорит, что, возможно, для поддержания здоровья достаточно меньшего количества шагов.

Стоматологи неоправданно назначают огромное количество антибиотиков

Tue, 04 Jun 2019 17:30:30 +0000

Согласно американскому исследованию, опубликованному в JAMA Network Open, антибиотики, назначаемые стоматологами для предотвращения потенциальной инфекции, не нужны в 81% случаев.

ADA Standards Updated With Renal Guidance Based on CREDENCE

Tue, 04 Jun 2019 10:01:31 +0000

New renal management guidance is based on data from the recently reported Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy (CREDENCE) trial.
Medscape Medical News

Cardiac Arrest, Death During Elective PCI Concerningly Common

Tue, 04 Jun 2019 10:19:39 +0000

A European registry puts mortality at only about 50% if a patient arrests on the table during an elective percutaneous coronary intervention.
Medscape Medical News

Hospitals Accused of Paying Doctors Kickbacks in Quest for Patients

Tue, 04 Jun 2019 10:21:11 +0000

Hospitals are eager to get particular specialists on staff because they bring in business. But those efforts, if they involve very high salaries or other enticements, can violate federal anti-kickback laws.
Kaiser Health News

Mixed ICH Patients at Higher Risk of Disability

Tue, 04 Jun 2019 10:23:26 +0000

Mixed ICH, showing features of both lobar and deep ICH, appears to carry risk for worse outcomes than those with strictly lobar or deep ICH presentation, new research suggests.
Medscape Medical News

Cardiologist Settles Suit for $5.8M for Alleged Unneeded Stents

Tue, 04 Jun 2019 07:20:01 +0000

Joseph Galichia, MD, and his group agree to pay the money but still deny allegations; cardiologist to be excluded from government health programs for 3 years.
Medscape Medical News

«Надо вылечить, а не просто отрезать воспаленный орган»

Tue, 04 Jun 2019 09:01:18 +0000

Нарушение прикуса это не только эстетическая проблема. В результате этой стоматологической патологии страдают многие органы и системы – от суставов до желудочно-кишечного тракта. У детей первыми последствиями нарушения прикуса становятся болезни ЛОР-органов, которые до недавнего времени лечили преимущественно хирургическим путем. Сегодня взгляд на эту проблему меняется.

Sexual Harassment Reported by 64% of Gynecologic Oncologists

Mon, 03 Jun 2019 18:08:00 +0000

Nearly two thirds of respondents to a new survey of members of the Society of Gynecologic Oncology reported experiencing some type of sexual harassment.
Medscape Medical News

Expanding Arthritis Therapies Top Agenda at EULAR

Mon, 03 Jun 2019 16:53:17 +0000

Much-needed options for osteoarthritis will be highlighted at the upcoming European League Against Rheumatism (EULAR) Congress.
Medscape Medical News

Immigrants Make Up Large Portion of US Healthcare Workforce

Mon, 03 Jun 2019 17:13:02 +0000

Foreign-born workers make a disproportionately high contribution to the healthcare of US-born individuals, a study finds.
Medscape Medical News

Dual Antibiotic Zerbaxa Gets FDA Nod for Bacterial Pneumonia

Mon, 03 Jun 2019 17:32:46 +0000

Zerbaxa (ceftolozane and tazobactam) for hospital- and ventilator-associated bacterial pneumonia was initially approved for complicated intra-abdominal and urinary tract infections.
FDA Approvals

ACP Guidance on Physician Impairment Emphasizes Rehabilitation

Mon, 03 Jun 2019 17:41:38 +0000

American College of Physicians guidance outlined the duties clinicians and health systems have to ill or impaired physicians and their patients: Doc rehabilitation should be the goal whenever possible.
Medscape Medical News

Patients With Food Allergies Benefit From Compassionate Care

Mon, 03 Jun 2019 16:08:41 +0000

People with allergies can have complex feelings about the risks they face, and it is important that they trust their healthcare providers as they learn about healthy, safe diets.
Medscape Medical News

Statins May Cut Postconcussion Dementia Risk

Mon, 03 Jun 2019 16:23:03 +0000

Concussion in older adults is tied to a dramatically increased risk for dementia, but new research suggests statins may mitigate this risk.
Medscape Medical News

FDA Pilot Program Simplifies Access to Unapproved Cancer Drugs

Mon, 03 Jun 2019 16:43:34 +0000

Project Facilitate creates a single point of contact through a dedicated call center where FDA oncology staff will help process expanded access requests.
Medscape Medical News

Misleading Advertising Claims by Proton Beam Therapy Centers

Mon, 03 Jun 2019 15:00:18 +0000

Direct-to-consumer advertising and claims made by facilities who offer this treatment do not always reflect the reality of proton beam therapy, say researchers.
Medscape Medical News

Trimethoprim-Sulfamethoxazole Linked to ARDS

Mon, 03 Jun 2019 15:08:22 +0000

Severe acute respiratory distress syndrome has been linked to trimethoprim-sulfamethoxazole treatment in previously healthy teenagers in a recent case series.
Medscape Medical News

Novel Anti-PCSK9 Fusion Protein Slashes LDL-C Levels

Mon, 03 Jun 2019 13:56:38 +0000

LIB003 induced a 'rapid, sustained, and significant mean reduction' in LDL cholesterol and PCSK9, with patient convenience a potential advantage over monoclonal antibodies, company researchers say.
Medscape Medical News

Maternal BMI Biggest Indicator of Risk for Childhood Obesity

Mon, 03 Jun 2019 14:13:59 +0000

Glucose levels elevated in pregnancy but below the threshold for diagnosis of gestational diabetes are nevertheless associated with obesity in the offspring; however, maternal BMI plays the biggest role.
Medscape Medical News

Cannabinoid May Boost Psychotherapy Efficacy in OCD

Mon, 03 Jun 2019 14:46:41 +0000

Adding nabilone, a THC analogue and cannabinoid 1 receptor agonist, may enhance the effectiveness of exposure-based cognitive behavioral therapy in patients with severe obsessive compulsive disorder.
Medscape Medical News

AHA Scientific Statement on CVD and HIV

Mon, 03 Jun 2019 14:48:23 +0000

The American Heart Association provides 'pragmatic' recommendations on cardiovascular disease prevention and management in the growing number of people living with HIV infection.
Medscape Medical News

Ketamine May Help Teens With Resistant Depression

Mon, 03 Jun 2019 13:16:29 +0000

Ketamine produced a significant reduction of depressive symptoms in teens with treatment-resistant depression in this first RCT, but its effects on the developing brain need to be rigorously explored.
Medscape Medical News

Австралийским врачам пришлось тушить возгорание в грудной полости пациента

Mon, 03 Jun 2019 19:41:04 +0000

Австралийские врачи рассказали о редком курьезном случае возгорания в непосредственной близости от операционной раны во время ургентной операции на сердце. Врачи справились с необычной ситуацией и смогли нормально завершить операцию. Доклад прозвучал на ежегодном конгрессе Euroanaesthesia Европейского общества анестезиологии, сообщает портал Gizmodo.

Suicidal Thoughts Common in Women With PMDD

Mon, 03 Jun 2019 12:28:24 +0000

Suicidal ideation, both passive and active, occur in a subgroup of women with premenstrual dysphoric disorder.
Medscape Medical News

25 чашек кофе в день не повредят сосудам

Mon, 03 Jun 2019 14:55:00 +0000

Любителей кофе часто «пугают» его возможными негативными воздействиями на здоровье. Ученые успокоили кофеманов относительно возможной опасности кофе для сердца: чтобы повредить этот орган, нужно выпить не менее 25 чашек напитка.

FDA Panel Recommends Reclassifying Surgical Staplers

Mon, 03 Jun 2019 07:33:40 +0000

An FDA panel recommended changing the classifcation of surgical staplers from class I to class II medical devices.
Medscape Medical News

Мелкая моторика хирургов может страдать из-за образа жизни в детстве

Mon, 03 Jun 2019 10:26:12 +0000

Преподаватели медицинских школ США и Великобритании отмечают заметное ухудшение мелкой моторики у студентов и врачей-интернов, как пишет The New York Times. С одной стороны, это может быть связано с уменьшением количества практических занятий в начальной и средней школе. С другой стороны, слишком много времени дети проводят перед экранами, что также не развивает моторику.

Мобильные приложения для знакомств говорят о риске использования нездоровых практик похудения

Sun, 02 Jun 2019 15:59:32 +0000

Использование мобильных приложений для знакомств может быть связано с повышенным риском использованием нездоровых приемов для контроля веса. Люди, использующие эти приложения, чаще вызывают у себя рвоту, злоупотребляют слабительными и таблетками для похудения. Результаты исследования опубликованы в Journal of Eating Disorders.

'Chemoboy' Takes Center Stage at ASCO Meeting

Sat, 01 Jun 2019 18:28:54 +0000

Listening to what is important to the patient was a message highlighted at the opening ceremony of this year's annual meeting.
Medscape Medical News

1-in-4 NSCLC Patients Alive at 5 Years After Pembrolizumab

Sat, 01 Jun 2019 16:02:08 +0000

With up to a quarter of nonsmall-cell lung cancer patients treated with pembrolizumab "around 5 years from now, that completely changes our mindset," says David Graham, MD, Levine Cancer Institute.
Medscape Medical News

e-Cigs Don't Help People Quit, May Be Harmful, Clinicians Say

Fri, 31 May 2019 19:52:06 +0000

The European Respiratory Society says in a statement that there is no proof that heated tobacco delivery devices help people quit, and they can no longer recommend them as a harm-reduction strategy.
Medscape Medical News

US Drug Prices Rise in 'Highly Synchronized' Pattern

Fri, 31 May 2019 19:04:35 +0000

A new study reports "highly synchronized" changes in the prices of competing drugs, including widely used forms of insulin.
Medscape Medical News

Tackling Economic, Emotional Toll of Clinician Burnout Critical

Fri, 31 May 2019 18:00:20 +0000

A National Academy of Medicine project is drawing together many medical organizations to try to address the root causes of burnout among healthcare professionals.
Medscape Medical News

Gray Matter Imaging Reveals MS Changes Missed on Standard MRI

Fri, 31 May 2019 16:54:20 +0000

Structural changes and volume loss seen in gray matter can explain cognitive, clinical symptoms that are elusive on standard MRI in patients with primary progressive MS, researchers say.
Medscape Medical News

Physician Misconduct Often Goes Unreported, Survey Shows

Fri, 31 May 2019 16:02:12 +0000

Nearly 1-in-5 Americans believe they have experienced physician misconduct, but few report it to state medical boards, according to a new FSMB survey.
Medscape Medical News

Water Polo Players Sustain Frequent Head Impacts

Fri, 31 May 2019 15:12:40 +0000

College athletes playing water polo may sustain more head impacts than people have realized, a U.S. study suggests.
Reuters Health Information

US Pathologist Supply Down Relative to Diagnostic Demands

Fri, 31 May 2019 15:07:01 +0000

The number of US pathologists continues to trend downward, despite a corresponding rise in diagnostic demands, according to 10-year data.
Medscape Medical News

PASTA: Does Extra Paramedic Intervention Affect Stroke Outcome?

Fri, 31 May 2019 15:07:55 +0000

Enhanced paramedic assessment of stroke patients did not result in more patients receiving thrombolysis, but was associated with reduced subsequent care costs, in a new study.
Medscape Medical News

Rivaroxaban Cuts Stroke Risk in HF Sans AF: Post Hoc COMMANDER-HF

Fri, 31 May 2019 15:44:16 +0000

Oral anticoagulation may have struck the right balance between stroke benefit and bleeding risk in systolic heart failure. Also, a stroke risk prediction tool may be more versatile than expected.
Medscape Medical News

Male, Minority, Uninsured Smokers Less Likely to Get Quit Help

Fri, 31 May 2019 13:58:55 +0000

The percentage of smokers advised to quit by their primary-care physician (PCP) has inched up in recent years, but men, younger people and minorities are significantly less likely to get this advice, new findings show.
Reuters Health Information

FDA Warns Another Stem Cell Company For Unapproved Treatments

Fri, 31 May 2019 14:15:00 +0000

FDA letter claimed R3 Stem Cells LLC is marketing products for which it has neither a biologics license nor an IND, is pushing unapproved uses, and is recommending high-risk routes of administration.
Medscape Medical News

Hashtag Medicine: Tweeting at ASCO

Fri, 31 May 2019 14:45:07 +0000

Use the main hashtag plus oncology 'micro-hashtags' to follow the conference on Twitter.
Medscape Medical News

Methylphenidate Dose Titration in ADHD Should Be Based on Outcomes

Fri, 31 May 2019 13:45:30 +0000

Dose titration of methylphenidate in patients with attention-deficit/hyperactivity disorder (ADHD) should aim to maximize the ratio of benefit to adverse effects, as there appears to be no scientific rationale for published maximum doses, according to a meta-analysis.
Reuters Health Information

Using ASCO's Clinical Database for Commercial Research Raises Questions

Fri, 31 May 2019 12:29:09 +0000

Ethicists have expressed concern that a CancerLinQ database of deidentified patient medical records is being monetized for research without asking for informed consent.
Medscape Medical News

New Lymphoma Drugs Build on BTK Inhibitor Success

Fri, 31 May 2019 12:51:50 +0000

Life expectancy for patients with Waldenstrom's macroglobulinemia has improved considerably in the past decade, and new treatments on the horizon could mean that trend continues.
Medscape Medical News

Misconception That Pancreatic Cancer 'Not Worth Treating'

Fri, 31 May 2019 10:25:42 +0000

A Canadian study shows that one third of patients were not referred to oncology service and that 64% did not receive treatment to prolong survival or reduce symptom burden.
Medscape Medical News

Mental Healthcare Access Line Helps Rural Pediatricians Help Kids in Need

Fri, 31 May 2019 10:39:13 +0000

A program in North Carolina provides real-time phone consultation to rural pediatric providers on managing mental health issues in their patients.
Medscape Medical News

Minor Stroke, TIA Diagnosis More Often Missed in Women

Fri, 31 May 2019 07:17:31 +0000

Despite presenting with similar symptoms, women were less likely to be diagnosed with an ischemic cerebrovascular event, but 90-day recurrent stroke rates were similar for the two sexes.
Medscape Medical News

«Осталось убедить людей приходить на обследование, иногда даже хочется делать это насильно»

Fri, 31 May 2019 10:30:03 +0000

Онколог – это не тот специалист, который занимается ранней диагностикой рака. Онконастороженность должны проявлять врачи первичного звена. Да и каждому человеку следует внимательно относиться к любым неясным симптомам, не вписывающимся в схемы привычных заболеваний. Современная медицина научилась справляться с раком, но только если удается диагностировать его на ранних стадиях.

Дети, которых дразнят из-за избытка веса, чаще набирают еще большую массу тела

Fri, 31 May 2019 09:45:55 +0000

Часто дети с избыточным весом и ожирением жалуются, что их дразнят по поводу их веса, но мало что известно о том, как это впоследствии воздействует на их массу тела. Согласно новому американскому исследованию, опубликованному в журнале Pediatric Obesity, дети и подростки, которых дразнили по поводу их веса, со временем набирали еще большую массу тела.

Missouri Governor Says State's Intent to Close Only Abortion Clinic Not Political

Thu, 30 May 2019 22:57:56 +0000

Missouri Governor Mike Parson on Wednesday said politics played no role in the state department of health's intent to close Missouri's sole abortion clinic, a move that would make it the only U.S. state with no legal abortion provider.
Reuters Health Information

Most Face Transplant Patients Continue to Report Better Quality of Life

Thu, 30 May 2019 22:20:36 +0000

Doctors at Brigham and Women's Hospital in Boston say most of the face transplant patients they have been following for about five years are continuing to show improvement in quality of life.
Reuters Health Information

Measles Cases Highest Since 1992, Elimination Status in Jeopardy

Thu, 30 May 2019 17:46:56 +0000

The number of US measles cases in first 5 months of 2019 have surpassed the total number of cases for any year since 1992, the CDC said today.
Medscape Medical News

[Viewpoint] Trickle-down innovation and the longevity of nations

Thu, 30 May 2019 23:00:08 +0000

The association between income and life expectancy is so robust and persistent across countries that it has a name, the Preston Curve, named after the economist who first described it.1 The strength of the association begs the question: must citizens of poorer countries wait for their economies to grow before they can expect to enjoy the life expectancies of wealthier nations? Or can longevity improve, even in the absence of economic gains? The answer has important implications for human wellbeing around the world.

[Health Policy] Preconception health in England: a proposal for annual reporting with core metrics

Thu, 30 May 2019 23:00:08 +0000

There is growing interest in preconception health as a crucial period for influencing not only pregnancy outcomes, but also future maternal and child health, and prevention of long-term medical conditions. Successive national and international policy documents emphasise the need to improve preconception health, but resources and action have not followed through with these goals. We argue for a dual intervention strategy at both the public health level (eg, by improving the food environment) and at the individual level (eg, by better identification of those planning a pregnancy who would benefit from support to optimise health before conception) in order to raise awareness of preconception health and to normalise the notion of planning and preparing for pregnancy.

[Clinical Picture] Tropical megaloblastic anaemia

Thu, 30 May 2019 23:00:08 +0000

A 40-year-old woman attended our hospital complaining of excessive darkening over her fingers and toes, and on the palms of her hands, and the soles of her feet: she also said she got tired easily, had a burning sensation in her mouth, and had become increasingly forgetful over the past 12 months. Additionally, she reported having chest pain brought on by exertion for the past 2 months. She had no medical history suggesting malabsorption, recurrent epigastric pain suggesting a hookworm infestation, or blood loss.

[Articles] Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995–2050

Thu, 30 May 2019 23:00:08 +0000

Financing for global health has increased steadily over the past two decades and is projected to continue increasing in the future, although at a slower pace of growth and with persistent disparities in per-capita health spending between countries. Out-of-pocket spending is projected to remain substantial outside of high-income countries. Many low-income countries are expected to remain dependent on development assistance, although with greater government spending, larger investments in health are feasible.

[Articles] Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety

Thu, 30 May 2019 23:00:08 +0000

In patients with peanut allergy, high-certainty evidence shows that available peanut oral immunotherapy regimens considerably increase allergic and anaphylactic reactions over avoidance or placebo, despite effectively inducing desensitisation. Safer peanut allergy treatment approaches and rigorous randomised controlled trials that evaluate patient-important outcomes are needed.

[Articles] Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Thu, 30 May 2019 23:00:08 +0000

No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care.

[Articles] Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial

Thu, 30 May 2019 23:00:07 +0000

An ultra-short-term combination treatment with intravenous iron, subcutaneous erythropoietin alpha, vitamin B12, and oral folic acid reduced RBC and total allogeneic blood product transfusions in patients with preoperative anaemia or isolated iron deficiency undergoing elective cardiac surgery.

[Department of Error] Department of Error

Thu, 30 May 2019 23:00:07 +0000

Usher AD. Low-cost pneumonia vaccine breaks into global market. Lancet 2019; 393: 2025–26—In this World Report, the following sentence was added for clarity: “Serum says that two factors can cause the price to increase: first, if the quantities ordered are lower than 10 million doses, the price could go up to $9 per child.” This correction has been made to the online version as of May 30, 2019.

[Department of Error] Department of Error

Thu, 30 May 2019 23:00:07 +0000

Vennix S, Musters GD, Mulder IM, et al. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386: 1269–77—In this Article, the individual Ladies trial collaborators were not indexed on PubMed. This correction has been made to the online version as of May 30, 2019.

[Correspondence] Scientific opportunities for nutrition security

Thu, 30 May 2019 23:00:07 +0000

In an Editorial1 about the policy brief by the Global Panel on Agriculture and Food Systems for Nutrition,2 the Editors note some important issues when addressing nutrient losses in food systems and, rightly, call for more to be done to motivate multisectoral partnerships.

[Correspondence] Detection of coronary inflammation – Authors' reply

Thu, 30 May 2019 23:00:07 +0000

We thank Abass Alavi and colleagues and Gaston A Rodriguez-Granillo and Patricia Carrascosa for their comments on the CRISP CT study.1

[Correspondence] Detection of coronary inflammation

Thu, 30 May 2019 23:00:07 +0000

By use of coronary CT angiography in two large real-life prospective cohorts from completely different populations, Evangelos K Oikonomou and colleagues1 validated the prognostic value of a non-invasive marker of coronary inflammation, the perivascular fat attenuation index.2 In this study, a fat attenuation index higher than −70·1 Hounsfield units was identified as a strong predictor of all-cause and cardiac mortality, independent of demographics, epicardial fat volume, high-risk plaque features, and the extent of atherosclerosis.

[Correspondence] Detection of coronary inflammation

Thu, 30 May 2019 23:00:07 +0000

We read with great interest Evangelos K Oikonomou and colleagues' Article1 about the importance of the perivascular fat attenuation index in detection of coronary inflammation as assessed by cardiac CT. The authors concluded that the perivascular fat attenuation index provides a quantitative measure of coronary inflammation and is potentially superior to other imaging techniques used for this purpose. We wish to point out that gross structural changes visualised by conventional radiological techniques, including CT and MRI, are due to the late and advanced stages of the disease, when the process is irreversible and cannot be successfully treated with non-invasive interventions.

[Correspondence] Health and climate change – Authors' reply

Thu, 30 May 2019 23:00:07 +0000

We thank Timothy Florin and David Allen for their response to our 2018 Review.1 Our research collaboration exists to track progress in quantifying the links between public health and climate change, and has always sought to encourage scientific discussion on the topic. We also acknowledge the unpublished 34-page critique from Allen in response to our 2015 Lancet Commission, in which he, among other points, extolled the benefits of clean coal, and equated the work of the Intergovernmental Panel on Climate Change to that of “the domain of prophets, clairvoyants, and science fiction”.

[Correspondence] Health and climate change

Thu, 30 May 2019 23:00:07 +0000

We commend The Lancet for addressing climate change and health but think the 2018 report of the Lancet Countdown on health and climate change by Nick Watts and colleagues1 compromises the journal's standard of objectivity. The Article is based on ten recommendations of the 2015 Lancet Commission on Health and Climate Change,2 for which one of us provided a critique to the lead author in 2015.

[Correspondence] Supporting female scientists in Africa

Thu, 30 May 2019 23:00:07 +0000

As a female African scientist from central Africa, the region of Africa that contributes the least to the continent's research outputs, I am convinced that the training, employment, and promotion of women in science are essential components of efforts to advance health research and services in Africa. I have this conviction because of my own experience.

[Correspondence] Gender and funding success

Thu, 30 May 2019 23:00:07 +0000

Holly Witteman and colleagues1 reported lower success rates for senior female researchers when the applicant (rather than the project) was evaluated in research grant competitions. Data from Parkinson Canada, another national Canadian funding agency, can inform on gender and funding success at early career stages.

[Correspondence] Gender bias in CIHR Foundation grant awarding

Thu, 30 May 2019 23:00:07 +0000

Holly Witteman and colleagues1 point out a discrepancy in the success rates of Canadian Institutes of Health Research (CIHR) Foundation grantees by gender. The Foundation programme was initiated in 2014 to help senior investigators (level 2) complete their research objectives unencumbered by the inordinate time and effort required to prepare grant submissions, and was expanded in 2015 to include several promising junior investigators (level 1). The authors show that among the applicants, 64 (9·2%) of 698 women were successful, compared with 199 (14%) of 1427 men.

[Obituary] Paul Greengard

Thu, 30 May 2019 23:00:07 +0000

Nobel laureate who helped uncover the biochemistry of the mind. Born on Dec 11, 1925, in Brooklyn, NY, USA, he died on April 13, 2019, in New York City, NY, USA, aged 93 years.

[Perspectives] Marie Boivin: from midwife to gynaecologist

Thu, 30 May 2019 23:00:07 +0000

The authoritative Traité pratique des maladies de l'uterus et de ses annexes, published in Paris in 1833, was one of the most forward-thinking gynaecological texts of 19th-century Europe. It was more specific than previous texts, such as the British physician Marshall Hall's Commentaries on Some of the More Important of the Diseases of Females of 1827, and it focused on the reproductive organs as a system rather than simply in relation to childbirth. This textbook was based not on previous authorities but on first-hand case studies and autopsies, including the first account of the surgical removal of a cancerous cervix.

[Perspectives] How China became a cigarette superpower

Thu, 30 May 2019 23:00:07 +0000

Among the most striking public health conundrums today is how little we know about the world's largest producer and consumer of cigarettes. China is home to an estimated third of the world's smokers—more than 300 million people who collectively consume around 40% of the world's cigarettes. The China National Tobacco Corporation and its administrative arm, the State Tobacco Monopoly Administration, supply an estimated 2600 billion cigarettes annually to meet this enormous demand. The rest are locally manufactured, imported, or smuggled international brands of leading transnational tobacco companies.

[Perspectives] Long data from the electrocardiogram

Thu, 30 May 2019 23:00:07 +0000

The first capture of the electrical activity of the heart—the PQRST complex—was done by Willem Einthoven in 1895, using a 600-pound machine and five skilled operators, with a simple request for patients to place their hands and one foot inside buckets filled with an electrolyte solution. Eventually, the 12-lead electrocardiogram (ECG) in hospital and clinic settings evolved, requiring a big machine on wheels with multiple cables for each limb and across the chest. Today, by touching a sensor with our fingers and the left leg, forming Einthoven's triangle, we can instantly record a high-quality six-lead ECG to a smartphone.

[World Report] UNAIDS survey aligns with so-called fourth 90 for HIV/AIDS

Thu, 30 May 2019 23:00:07 +0000

The survey echoes a trend in the community to take notice of mental wellness when thinking of public health interventions to fight HIV/AIDS. Paul Webster reports.

[World Report] Brazil sues cigarette manufacturers for public health costs

Thu, 30 May 2019 23:00:07 +0000

Brazil argues the companies should repay the cost their product incurs on public health, opening avenues for other countries to do the same. Lise Alves reports from São Paulo.

[World Report] Colombia struggles to cope with care in Venezuelan influx

Thu, 30 May 2019 23:00:07 +0000

Venezuelans fleeing their country in large numbers place a heavy burden on Colombia's health system, although its government is intent on helping. Joe Parkin Daniels reports from Bogotá.

[Comment] Offline: WHO—the story so far…

Thu, 30 May 2019 23:00:07 +0000

Health workers are not philosophers. But there are moments, poignant moments, when the true contributions and costs of working in health can be seen and reflected upon with fresh eyes. Last week, when Friquette Tata Mouzoko and her eldest daughter, Beleck Margaret, walked on stage during the opening of the 72nd World Health Assembly, there was a pause in time. In silence, delegates from 194 member states remembered what their work, at its extremes, is all about—courage and sacrifice, sometimes in the face of lethal danger.

[Comment] Leveraging climate change to improve global tobacco control

Thu, 30 May 2019 23:00:06 +0000

With efforts in tobacco control plateauing throughout much of Asia-Pacific and in parts of eastern Europe and Latin America over the past decade, cigarette smoking remains a defining health challenge globally.1 By far the number one killer of men worldwide, it is also a top cause of morbidity and mortality in women, while exposure to second-hand smoke is a concern in megacities across the southern hemisphere.1

[Comment] Peanut oral immunotherapy: balancing benefits and risks for individuals

Thu, 30 May 2019 23:00:06 +0000

Peanut allergy affects around 2% of the population.1 Fatal anaphylactic reactions are rare but can occur.2 It has a considerable negative impact on the quality of life of patients and their families,3 and all patients need to avoid peanuts and carry self-injectable adrenaline. With many foods being labelled as “may contain nuts”, complete avoidance is a challenge.4 Until this decade, no treatment for food allergy was available;5,6 hence considerable efforts were made to develop oral immunotherapy for food allergy.

[Comment] Emergency general surgery: can we do better?

Thu, 30 May 2019 23:00:06 +0000

In The Lancet, Carol Peden and colleagues1 report a randomised trial of a quality improvement (QI) effort to enhance the outcomes of emergency abdominal surgery. The Enhanced Peri-Operative Care for High-risk patients (EPOCH) group attempted to implement a 37-element care bundle at 93 hospitals across the UK. National Health Service hospitals doing a substantial volume of emergency abdominal surgery and contributing to the National Emergency Laparotomy Audit were eligible for inclusion. The most frequently enrolled patients had intestinal obstruction or perforation.

[Comment] A one-shot solution for improved patient blood management in cardiac surgery?

Thu, 30 May 2019 23:00:06 +0000

Preoperative anaemia and low intraoperative haemoglobin (Hb) concentration remain independent risk factors for serious adverse outcomes, including mortality and major morbidity in patients undergoing cardiac surgery.1 However, effective therapies that reduce the incidence of these adverse events remain to be identified. Retrospective data and a recent prospective randomised controlled trial (RCT) suggest that red blood cell (RBC) transfusions might not adequately treat the mechanism of organ injury associated with anaemia2,3 or that they might cause additional morbidity.

[Editorial] Protect lives before political interest in the Middle East

Thu, 30 May 2019 23:00:06 +0000

Tensions between Iran and the USA are rising, as US President Trump's acrimonious language fuels an already incendiary situation. In the latest development, Trump announced he would be sending troops and fighter jets to the Middle East to counter what the administration called Iran's escalating campaign to plan attacks against the USA. In a move labelled “extremely dangerous” for international peace by Iranian Foreign Minister Mohammad Javad Zarif, on May 25, Trump also approved the sale of billions of dollars' worth of weapons to its Yemen war coalition partner Saudi Arabia.

[Editorial] US public charge rule: pushing the door closed

Thu, 30 May 2019 23:00:06 +0000

The chilling effect of the Trump Administration's proposed change in the so-called public charge rule (examining an immigrant's potential public burden) has been reported anecdotally since it was rumoured last year. But, until now, data on its consequences have been absent. On May 22, the Urban Institute released a brief outlining the first systemic evidence of how President Trump's policies are affecting resident noncitizens and their families. Based on their Well-Being and Basic Needs Survey, the brief looked at responses from nearly 2000 non-elderly adults in immigrant families.

US Measles Cases Top 1994 High, Elimination Status in Jeopardy

Thu, 30 May 2019 17:46:56 +0000

The number of US measles cases in first 5 months of 2019 have surpassed the total number of cases for any year since 1994, the CDC said today.
Medscape Medical News

Exercise Significantly Benefits Psychiatric Inpatients

Thu, 30 May 2019 15:51:27 +0000

Physical exercise can be a powerful therapy for psychiatric inpatients and reduces symptoms of anxiety, depression, anger, psychomotor agitation, and muscle tension.
Medscape Medical News

Obesity Gene Variants Predict Overeating in Slim Children

Thu, 30 May 2019 14:00:16 +0000

Study results extend prior work in children and adults with obesity by showing a dose-dependent effect of FTO gene variations on food intake in kids without obesity, researchers report.
Medscape Medical News

Sirolimus Linked to Lower Malignancy After Heart Transplant

Thu, 30 May 2019 14:12:49 +0000

A single-center cohort analysis demonstrates that converting heart transplant patients from standard immunosuppression to regimens that use sirolimus is associated with improved 10-year survival.
Medscape Medical News

Increased Hoarding, Cluttering in MS?

Thu, 30 May 2019 14:43:45 +0000

A new study shows rates twice that of the general population; experts suggest clinicians keep the issue on their radar.
Medscape Medical News

Fixed-Dose Bempedoic Acid, Ezetimibe Combo for Statin Intolerance?

Thu, 30 May 2019 14:53:26 +0000

The fixed-dose combination of the complementary drugs is 'potent and convenient,' researchers conclude, with statin intolerance potentially 'a very nice niche.'
Medscape Medical News

В Москве проходит XIII Всероссийский форум «Здоровье нации – основа процветания России»

Thu, 30 May 2019 20:49:52 +0000

Это крупнейшее в стране мероприятие, посвященное вопросам сохранения здоровья граждан, здорового образа жизни и здоровьесберегающих технологий. В этом году главная тема форума – задачи развития страны в области демографии, жилья и городской среды, образования, экологии и здравоохранения. В раках форума в «Гостинном дворе» проводится выставка «Здоровье для всех».

Patients With Rare Lymphoma Describe Divergent Experiences

Thu, 30 May 2019 13:00:34 +0000

Some people are treated aggressively while others watch and wait until symptoms appear; three will describe their experiences at the upcoming Waldenstrom's Macroglobulinemia forum.
Medscape Medical News

Imaging Agent from Scorpions May Improve Brain Tumor Resection

Thu, 30 May 2019 13:06:06 +0000

New study finds that tozuleristide helps both high- and low-grade glial tumors with little toxicity.
Medscape Medical News

ARC-HRB Defines High Bleeding Risk in PCI Patients

Thu, 30 May 2019 13:13:14 +0000

The definition addresses an unmet need by providing a framework for evaluating treatment options for PCI patients at increased bleeding risk.
Medscape Medical News

A Doctor Speaks Out About Ageism in Medicine

Thu, 30 May 2019 13:23:01 +0000

A frank conversation with geriatrician and author Dr. Louise Aronson about medicine's biased treatment of older adults and what needs to change.
Kaiser Health News

Botox May Help Bipolar Depression, Social Anxiety

Thu, 30 May 2019 11:23:30 +0000

In two small case series, injections of botulinum toxin into the glabellar region -- the area between the eyebrows and above the nose -- reduced symptoms of bipolar depression and social anxiety.
Medscape Medical News

Waterfall Plots Oversell Response Rates in Cancer Trials

Thu, 30 May 2019 03:27:27 +0000

Graphs known as waterfall plots exaggerate cancer-treatment response rates, and their use in oncology literature is increasing, according to new findings.
Reuters Health Information

J&J's Greed Helped Fuel U.S. Opioid Crisis, Oklahoma Claims at Trial

Thu, 30 May 2019 03:09:52 +0000

Johnson & Johnson's greed led the drugmaker to use deceptive marketing to create an oversupply of painkillers that fueled the U.S. opioid epidemic, the state of Oklahoma alleged at the start of the first trial to result from lawsuits over the drug crisis.
Reuters Health Information

WHO Counts Down Africa Polio Clock Despite Fears of New Outbreak

Thu, 30 May 2019 03:04:39 +0000

Africa could be declared free of endemic "wild" polio early next year if a strain last seen in Nigeria almost three years ago does not resurface, the World Health Organization's Africa director said on Tuesday.
Reuters Health Information

Missouri to Be Only U.S. State With No Legal Abortion Provider After State Action

Thu, 30 May 2019 03:04:16 +0000

Missouri is poised this week to become the only U.S. state without access to legal abortions as health officials refuse to renew its last clinic's license to perform the procedure, women's health services provider Planned Parenthood said on Tuesday.
Reuters Health Information

New Markers Protect in Diabetic Kidney Disease; Hope for Therapy

Thu, 30 May 2019 10:44:22 +0000

Study identifies proteins that protect against development of diabetic kidney disease with potential as biomarkers and/or for development of new therapeutics.
Medscape Medical News

New HRS Consensus on Arrhythmogenic Cardiomyopathy

Thu, 30 May 2019 09:19:06 +0000

A new consensus statement provides guidance on evaluation and management of arrhythmogenic cardiomyopathy, including clinically relevant information on genetics and disease mechanisms.
Medscape Medical News

New Diabetes Cases in US Fall by 35% After 20-Year Rise

Thu, 30 May 2019 09:45:06 +0000

Diabetes incidence declined while prevalence stayed steady, but overall numbers remain high. Reasons for the fall in the number of new cases is unclear; experts hope tide is turning despite rising obesity.
Medscape Medical News

«Есть только один способ укрепить защитные силы организма – здоровый образ жизни»

Thu, 30 May 2019 15:18:03 +0000

Из-за малоподвижного образа жизни и неправильного питания 4 из 5 детей выходят из школы с проблемами здоровья различной тяжести. Более половины школьников 7–9 лет и 60% старшеклассников имеют хронические заболевания. К 16 годам 40% девушек и 60% юношей имеют факторы риска развития сердечно-сосудистых заболеваний И в целом число абсолютно здоровых школьников не превышает 10-12%.

Проблема сезона: в России просыпаются клещи

Thu, 30 May 2019 08:35:54 +0000

Роспотребнадзор сообщил о начале сезона активности клещей. Пока случаи заражения клещевым энцефалитом и боррелиозом единичны. Пик заболеваемости еще впереди. Ежегодно в нашей стране от укусов клещей заболевает 8-10 тысяч человек. Жителей центральной России чаще всего поражает боррелиоз – опасная инфекция, способная привести к инвалидности. И прививки от нее пока нет.

WHO Agrees Watered-Down Resolution on Transparency in Drug Costs

Wed, 29 May 2019 18:57:18 +0000

Countries at the World Health Organization agreed on Tuesday to push for clearer drug pricing, after watering down a draft resolution that would have also required pharmaceutical firms to disclose the cost of making medicines.
Reuters Health Information

Allergan's Vraylar Wins U.S. FDA Approval for Bipolar Depression

Wed, 29 May 2019 19:00:06 +0000

Allergan Plc's Vraylar won U.S. regulatory approval to treat depressive episodes of bipolar I disorder, expanding its scope of treatment to a full spectrum of symptoms related to the condition, the company said on Monday.
Reuters Health Information

Atezolizumab Plus Bevacizumab Might Help Some With Kidney Cancer

Wed, 29 May 2019 19:02:11 +0000

The anti-VEGF monoclonal antibody bevacizumab combined with the anti-PD-L1 antibody atezolizumab might beat sunitinib in some patients with previously untreated advanced renal-cell carcinoma (RCC), but uncertainty remains, according to a phase 3 trial.
Reuters Health Information

New Therapy Improves Survival in Hepatoma With Portal-Vein Invasion

Wed, 29 May 2019 19:06:09 +0000

In patients with hepatocellular carcinoma (HCC) and portal-vein invasion, sorafenib combined with hepatic arterial infusion chemotherapy (HAIC) improves overall survival compared with sorafenib alone, researchers from China report.
Reuters Health Information

Attention to Healthy Lifestyle at an Early Age Key to Preventing Heart Disease

Wed, 29 May 2019 19:28:03 +0000

Updated clinical practice guidelines on the management of blood cholesterol encourage adopting a heart-healthy lifestyle beginning in childhood to reduce lifetime risk for atherosclerotic cardiovascular disease (ASCVD), according to a new report.
Reuters Health Information

Blood Donor Screening May Detect Familial Hypercholesterolemia

Wed, 29 May 2019 19:28:17 +0000

A blood donation screening program has the potential to identify and notify individuals with undiagnosed familial hypercholesterolemia (FH), according to a proof-of-concept study.
Reuters Health Information

Ultra-Processed Food, Drink Tied to Heart Disease, Earlier Death

Wed, 29 May 2019 18:55:41 +0000

Findings from France and Spain add to growing evidence, experts say. "The dietary advice is relatively straightforward: eat less ultra-processed food and more unprocessed or minimally processed food."
Medscape Medical News

THAWS: Neutral Result in 'Wake-up' Stroke With Low-Dose tPA

Wed, 29 May 2019 17:49:28 +0000

The Japanese trial was stopped early after the positive results of the WAKE-UP trial last year, precluding "any definitive conclusions," researchers say.
Medscape Medical News

Daratumumab Triplet for First-Line Myeloma, but Questions Remain

Wed, 29 May 2019 17:00:49 +0000

The daratumumab, lenalidomide, and dexamethasone triplet is a new frontline option for patients with multiple myeloma who are not candidates for transplant, but how practice-changing are the data?
Medscape Medical News

Sustained Lower BP After Acute ICH Linked to Better Outcomes

Wed, 29 May 2019 17:07:13 +0000

Researchers combined data from two large trials with divergent findings to determine how lowering of blood pressure after acute intracranial hemorrhage (ICH) affects 90-day outcomes.
Medscape Medical News

Ibrutinib and Venetoclax Combo 'Impressive' in Front-Line CLL

Wed, 29 May 2019 17:10:16 +0000

The combination of ibrutinib and venetoclax has shown 'impressive results' in the front-line treatment of chronic lymphocytic leukemia (CLL), and may not need to be continued indefinitely.
Medscape Medical News

Health System Starts Infectious Disease Telemedicine Company

Wed, 29 May 2019 17:41:20 +0000

Infectious Disease Connect will start with smaller hospitals, helping them expand their ID reach and keep patients closer to home.
Medscape Medical News

Novel Medication May Help Binge Eating Disorder

Wed, 29 May 2019 16:12:50 +0000

Dasotraline, a norepinephrine-dopamine reuptake inhibitor in development, is associated with less binge eating and related obsessional thoughts and compulsive behaviors.
Medscape Medical News

Factors Linked to LDL-Cholesterol Levels Differ by Gender

Wed, 29 May 2019 16:50:22 +0000

Different impact of lifestyle and genetic factors on LDL-cholesterol levels in men and women could have 'strong repercussions' for treatment, researchers say.
Medscape Medical News

Emory Says 2 Scientists Depart After Failing to Disclose China Ties

Wed, 29 May 2019 15:05:26 +0000

Two faculty members have left Emory University after failing to disclose foreign sources of research funding and their work with institutions and universities in China.
Georgia Health News

SelectSite C304-HIS Catheter Earns FDA Nod for His Bundle Pacing

Wed, 29 May 2019 13:56:30 +0000

Its adjustable curved design should help reach the bundle of His and accommodate and secure the pacing lead in more challenging anatomies, Medtronic says.
FDA Approvals

More Steps Per Day Tied to Lower Mortality in Older Women

Wed, 29 May 2019 14:00:16 +0000

Walking 4400 steps per day was linked to lower all-cause mortality in older women, a study found; the risk for death fell as the number of steps rose, levelling off after 7500 steps per day.
Medscape Medical News

Opioid Lawsuits Push Pain Society to Brink of Bankruptcy

Wed, 29 May 2019 14:17:34 +0000

In the face of continuing litigation against opioid manufacturers, which has ensnared the APS, the society asked its membership to vote on a recommendation from its board that it cease operations.
Medscape Medical News

Can Fracturing Calcium Deposits Clear a Path, Delay TAVR?

Wed, 29 May 2019 14:21:00 +0000

A novel scoring device that breaks up aortic calcium deposits improved aortic valve area and mobility, but one observer questions its role in the TAVR era.
Medscape Medical News

Escalating Workplace Violence Rocks Hospitals

Wed, 29 May 2019 14:33:29 +0000

Many healthcare workers say the physical and verbal abuse come mainly from patients, some of whom are disoriented from illness or medication. A hospital in Ohio installed a metal detector in the ER.
Kaiser Health News

Skin Microbiome's Emerging Role in Eczema

Wed, 29 May 2019 14:39:18 +0000

A combination Janus and spleen tyrosine kinase inhibitor improves eczema scores, but now researchers are examining its effect on Staphylococcus aureus in patients with atopic dermatitis.
Medscape Medical News

Do You Treat Patients Differently at the End of the Day?

Wed, 29 May 2019 12:56:48 +0000

Research studies suggest physicians order screening tests less frequently as the work day goes on.
Medscape Reader Polls

More Men Than Women Face Osteoporosis in Early Middle Age

Wed, 29 May 2019 13:07:54 +0000

'It really does boil down to use it or lose it,' says Martha Ann Bass, from the University of Mississippi, who recommends weight-bearing exercise to stave off age-related bone loss in men and women.
Medscape Medical News

ORION-2: Sustained LDL Reduction With Inclisiran in Homozygous FH

Wed, 29 May 2019 13:10:17 +0000

Prolonged effect plus marked LDL-cholesterol lowering may offer patients with familial hypercholesterolemia a convenient twice-a-year treatment option, a pilot study suggests.
Medscape Medical News

Heart (and Kidneys) Feature in Diabetes Trials in San Francisco

Wed, 29 May 2019 11:51:15 +0000

Sessions to cover highly anticipated novel clinical trial data in type 2 diabetes, as well as new analyses on renal and cardiovascular outcomes from previously reported studies, plus more on treatment and prevention.
Medscape Medical News

"Плохой холестерин" может оказаться причиной ранней болезни Альцгеймера

Wed, 29 May 2019 18:34:12 +0000

Исследователи из Медицинского центра по делам ветеранов в Атланте и Университета Эмори обнаружили связь между высоким уровнем ЛПНП (липопротеинов низкой плотности – «плохого» холестерина) и ранней болезнью Альцгеймера. Результаты исследования опубликованы в JAMA Neurology.

Ароматизированные жидкости для электронных сигарет повреждают сосуды даже без никотина

Wed, 29 May 2019 18:46:29 +0000

Новое исследование, проведенное учеными из Медицинской школы Стэнфордского университета, показало, что, возможно, электронные сигареты могут повреждать клетки кровеносных сосудов человека и увеличивать риск сердечно-сосудистых заболеваний. Одни ароматизированные жидкости для электронных сигарет наносят больший вред, чем другие, независимо от содержания никотина.

Could a Biomarker Take AVR to the New Aortic Stenosis Frontier?

Wed, 29 May 2019 11:08:40 +0000

Mortality climbs for patients with severe aortic stenosis who don't get a valve replacement because they are asymptomatic, especially if their natriuretic peptides are elevated, an analysis suggests.
Medscape Medical News

Young Stroke Survivors Face Increased Long-Term Death Risk

Wed, 29 May 2019 10:41:17 +0000

A national Dutch study in more than 15,000 adults younger than 50 who survived at least 30 days following a first stroke suggests higher mortality risks over time for these patients.
Medscape Medical News

Healthcare Professionals Divided on Medicare for All, Poll Shows

Wed, 29 May 2019 09:14:40 +0000

A Medscape poll shows that fewer than half support it. Top concerns were how to pay for it and bureaucracy, and more than half worry it could reduce physician salaries.
Medscape Medical News

Physicians Often Unsure of Diagnoses, Underestimate Error Rate

Wed, 29 May 2019 06:49:01 +0000

According to a recent study, clinicians are often unsure of diagnoses, but many underestimate the rate of diagnostic errors.
Medscape Medical News

Люди могут "плохо себя вести", когда работа регулярно не дает им выспаться

Wed, 29 May 2019 09:00:12 +0000

Жаворонки и совы склонны проявлять неэтичное и девиантное поведение, если их заставляют работать вне их естественных циркадных ритмов.

Mandatory Cognitive, Psychomotor Testing Urged for Older Surgeons

Wed, 29 May 2019 01:24:45 +0000

Mandatory cognitive and psychomotor testing of surgeons by at least age 65 should be implemented as part of ongoing professional evaluations, career transition discussions and other initiatives to support an aging workforce while ensuring patient safety, according to recommendations from the Society of Surgical Chairs (SSC).
Reuters Health Information

Seniors Who Feel Their Life Has Purpose May Live Longer

Wed, 29 May 2019 01:20:09 +0000

Seniors who feel their life has purpose may be less likely to die from heart, circulatory and digestive diseases and more likely to live longer, new data suggest.
Reuters Health Information

FDA Approves Combo for Indolent Non-Hodgkin Lymphomas

Tue, 28 May 2019 19:19:24 +0000

Lenalidomide may now be used in combination with rituximab for previously treated follicular lymphoma and previously treated marginal zone lymphoma.
FDA Approvals

Less Is More: Going Off Furosemide Can Be Safe in HF Outpatients

Tue, 28 May 2019 16:52:54 +0000

'Optimal meds' doesn't always mean higher doses. It can mean 'having people on the right regimen,' said an observer of the trial. Sometimes with loop diuretics, 'maybe the correct dose is a lower dose.'
Medscape Medical News

Staffing Costs as a Result of Physician Burnout Pegged at $4.6B

Tue, 28 May 2019 17:27:33 +0000

Taking care of physicians' emotional well-being and reducing burnout may be cheaper than ignoring it, according to a newly published analysis.
Medscape Medical News

Exposure to e-Cig Liquids Linked to Cell Damage In Vitro

Tue, 28 May 2019 15:27:17 +0000

In pluripotent stem cell-derived endothelial cells, researchers show the adverse impact of e-cigarette liquids on cellular function and integrity. Some flavors were worse than others.
Medscape Medical News

Antipsychotic Side Effects Tough to Take, Patients Say

Tue, 28 May 2019 14:13:16 +0000

Patients with schizophrenia who take second-generation antipsychotics often suffer side effects that significantly disrupt daily functioning and quality of life.
Medscape Medical News

Improving Metabolic Control to Postpone Dialysis

Tue, 28 May 2019 14:41:15 +0000

Diet plays a role in the progression of chronic kidney disease, but the extent to which patients should be burdened by dietary restrictions will be discussed at an upcoming renal congress in Europe.
Medscape Medical News

Prescription Stimulant Abuse in Youth Rising…Again

Tue, 28 May 2019 13:41:37 +0000

After a lull in the rates of stimulant abuse in children and teenagers, it looks as though the phenomenon is on the rise again, results of a new survey show.
Medscape Medical News

Complex PCI Favors Long-term Ticagrelor Monotherapy

Tue, 28 May 2019 13:41:49 +0000

Growing evidence supports long-term P2Y12 inhibitor monotherapy after short dual antiplatelet therapy, with results of two additional trials due later this year.
Medscape Medical News

FDA Okays Smartphone-Controlled Wearable for Migraine Pain

Tue, 28 May 2019 11:09:19 +0000

Worn on the upper arm and controlled via a smartphone, the Nerivio Migra utilizes remote electrical neuromodulation to relieve acute migraine pain.
FDA Approvals

Незамужние и бездетные женщины более счастливы и дольше живут

Tue, 28 May 2019 10:18:44 +0000

Незамужние и бездетные женщины – самая счастливая подгруппа населения. Вероятнее всего, они будут жить дольше, чем их сверстницы, находящиеся в браке и воспитывающие детей. Согласно последним научным данным, озвученным на музыкально-литературном фестивале Hay Festival, традиционные маркеры измерения успеха не коррелируют со счастьем – особенно это касается брака и воспитания де

Выгорание признали самостоятельным психическим расстройством

Tue, 28 May 2019 16:12:12 +0000

Всемирная организация здравоохранения впервые поместила «выгорание» в Международную классификацию болезней (МКБ). Решение, принятое во время 72-й Всемирной ассамблеи здравоохранения в Женеве, поможет положить конец десятилетиям споров между экспертами о том, как определять выгорание и следует ли считать его заболеванием.

Survey: Access to Physician Notes Helps Medication Adherence

Tue, 28 May 2019 08:01:25 +0000

Many patients in three large health systems who read their visit notes said the notes helped them understand and use their prescriptions; the benefit was particularly high at lower education levels.
Medscape Medical News

Незамужние и бездетные женщины более счастливы и дольше живут

Tue, 28 May 2019 10:18:44 +0000

Незамужние и бездетные женщины – самая счастливая подгруппа населения. Вероятнее всего, они будут жить дольше, чем их сверстницы, находящиеся в браке и воспитывающие детей. Согласно последним научным данным, озвученным на Хэй (литературном фестивале The Guardian), традиционные маркеры измерения успеха не коррелируют со счастьем – особенно это касается брака и воспитания детей.

Стартовал Первый Всероссийский фармпробег

Tue, 28 May 2019 09:41:28 +0000

За семь дней участники автопробега преодолеют почти 3000 км. Цель масштабной акции – развитие и поддержка всей цепочки фармацевтической отрасли: от производителей и аптек до врачей и пациентов. Задача деловой программы – оценить готовность регионов к внедрению новых моделей системы всеобщего лекарственного обеспечения, а также их возможности в фармацевтической отрасли.

Electrical Stimulation Promising in Acute Ischemic Stroke

Mon, 27 May 2019 16:52:28 +0000

A novel potential approach to treating acute ischemic stroke — by the electrical stimulation of an area at the back of the nose — has shown promising results in initial studies.
Medscape Medical News

Ultrasound 'Lung Comets' Hint Value as Treatment Target in HF

Mon, 27 May 2019 16:27:53 +0000

Clinic visits for worsening heart failure were fewer when diuretic changes were guided by the presence of B lines on lung scans, with their fanciful nickname, in a small randomized trial.
Medscape Medical News

Intra-aortic Balloon Pump May Best Inotropes in Decompensated HF

Mon, 27 May 2019 14:55:10 +0000

Five of 16 patients who received the IABP were bridged to a left ventricular assist device or heart transplant, vs none of those randomly assigned to inotropes.
Medscape Medical News

Can 'Controlled Diuresis' Avoid Diuretic Resistance in Acute HF?

Mon, 27 May 2019 12:57:53 +0000

Based on the tiny TARGET study, hopes are that controlled volume depletion using a proprietary device in acute heart failure could help clinicians push furosemide while avoiding diuretic resistance.
Medscape Medical News

Latest MS Advances, Strategies for Clinical Challenges at CMSC

Mon, 27 May 2019 13:20:51 +0000

The Consortium of Multiple Sclerosis Centers Annual Meeting has a multidisciplinary agenda covering everything from the latest in treatments to emerging evidence of underlying mechanisms.
Medscape Medical News

Как это делается: российским журналистам показали производство фармсубстанций во Франции

Mon, 27 May 2019 11:42:41 +0000

Российская фарминдустрия на 90% зависит от импорта субстанций, и их собственное производство – вопрос национальной безопасности. Но наладить такое производство – очень непростая задача. В этом российские журналисты убедились собственными глазами, посетив входящий в ГК «Сервье» завод Орил Индастри, который впервые за свою многолетнюю историю открыл двери для иностранных СМИ.

Ученые обнаружили опасное количество антибиотиков в реках по всему миру

Mon, 27 May 2019 14:23:06 +0000

Новое глобальное исследование показало, что сотни рек по всему миру, от Темзы до Тигра, содержат высокие количества антибиотиков. Из-за этого бактерии вырабатывают устойчивость ко многим из них, делая лечение менее эффективными.

Как это делается: российским журналистам показали производство фармсубстанций во Франции

Mon, 27 May 2019 11:42:41 +0000

Что делать, если у пожилого человека перелом бедра

Mon, 27 May 2019 08:57:07 +0000

Перелом шейки бедра – одна из самых распространенных и опасных травм в пожилом возрасте. Причиной перелома, как правило, является возрастной остеопороз. Существует множество разновидностей таких травм, но симптомы и уход за больными одинаковы. На самые распространенные вопросы, которые возникают у семей таких пациентов, ответил травматолог столичной ГКБ №17 Сергей Новиков.

Influenza Season Winds Down, but Not Done Yet, CDC Says

Fri, 24 May 2019 20:21:05 +0000

This influenza season is in its final stages but influenza is not completely gone just yet, according to the CDC.
Medscape Medical News

Physician Groups Decry Plan to Reverse Transgender Protections

Fri, 24 May 2019 19:44:06 +0000

Transgender individuals already are reluctant to seek care because of fears of discrimination, according to a recent survey.
Medscape Medical News

FDA OKs First Gene Therapy for Spinal Muscular Atrophy

Fri, 24 May 2019 17:20:59 +0000

A single, one-time infusion of onasemnogene abeparvovec-xioi (Zolgensma) can minimize the progression of SMA and improve survival in children younger than age 2 years — and will cost over $2 million.
FDA Approvals

U.S. Congress Considers Whether to Require Car Child Alerts

Fri, 24 May 2019 16:04:20 +0000

Automakers would be required to install technology on new vehicles that alerts exiting parents to check for children in the back seat under legislation introduced in Congress in response to deaths of children left behind in hot cars.
Reuters Health Information

Cataract Lens Replacement May Improve Sleep

Fri, 24 May 2019 15:58:17 +0000

People who get new lenses implanted during cataract surgery may not only see better but also experience better sleep, suggests a new study of how light entering the eye regulates the body's internal clock.
Reuters Health Information

Social Conflict Seeps Into Medical Societies

Fri, 24 May 2019 16:04:36 +0000

In U.S. medical society boardrooms, far from legislative chambers, social conflict is forcing board members to deal with laws that raise issues of medical ethics.
Reuters Health Information

Vaccine Refusal Persists After Personal Belief Exemptions Banned in California

Fri, 24 May 2019 15:41:22 +0000

A replacement effect may have "stifled" the effect of California's senate bill 277 (SB277), which banned non-medical vaccine exemptions for kindergarteners, researchers say.
Reuters Health Information

WHO Drug Pricing Talks May Fail to End Secrecy, Activists Fear

Fri, 24 May 2019 15:41:14 +0000

Governments are working on a drug pricing transparency deal at the World Health Organization's (WHO) annual assembly, but activists said on Thursday they fear crucial costs may be left out, enabling pharmaceutical firms to keep prices high.
Reuters Health Information

JPMorgan Cuts Ties With OxyContin Maker Purdue Pharma -Sources

Fri, 24 May 2019 15:36:07 +0000

JPMorgan Chase & Co has cut ties with Purdue Pharma LP over the OxyContin maker's alleged role in the U.S. opioid crisis, forcing it to find a new bank to manage cash and bill payments, people familiar with the matter said on Thursday.
Reuters Health Information

'Smart' Hearing Aids Would Identify Speakers in Crowded Room

Fri, 24 May 2019 15:35:55 +0000

People wearing hearing aids often struggle to differentiate between speakers in a crowded environment, but a small experiment suggests that brain-controlled assistive hearing devices would be able to detect which voice the user is paying attention to, and enhance it.
Reuters Health Information

Pharmacy School Dean Has Book Review Retracted

Fri, 24 May 2019 13:52:58 +0000

A book review by the incoming dean of a leading pharmacy school in Canada has been retracted from the Lancet because 'substantial passages...match parts of a review of the same book' by a newspaper columnist.
News Alerts

RATULS: No Advantage for Robotic Assist in Post-Stroke Rehab

Fri, 24 May 2019 13:59:37 +0000

Researchers compared robot-assisted upper limb training vs enhanced therapy or standard care in patients recovering from stroke, and find no advantage for the robotic assist.
Medscape Medical News

Children of Opioid Users More Likely to Attempt Suicide - U.S. Study

Fri, 24 May 2019 12:54:55 +0000

The U.S. opioid crisis is taking a toll on children of users as a study published this week showed they were more likely to attempt suicide.
Reuters Health Information

FDA OKs First Diagnostic Test for Prosthetic Joint Infections

Fri, 24 May 2019 13:14:37 +0000

The Synovasure Lateral Flow Test Kit is intended as an aid to determine whether there an infection is present in synovial fluid, but does not identify a specific type of infection.
FDA Approvals

Антипрививочники, узнавшие больше о боли инфекционных болезней, часто меняют свои убеждения

Fri, 24 May 2019 18:55:51 +0000

Большая часть студентов-антипрививочников, интервьюировавших людей с заболеваниями, которые можно было предупредить вакцинацией, изменила свою позицию на провакцинаторскую. В целом, 75% учащихся, выступавших против прививок, поменяли свое отношение к вакцинации, причем 50% полностью перешли в лагерь ее сторонников.

REVELATION: Drug-Coated Balloons Entices in Select STEMI

Fri, 24 May 2019 12:04:06 +0000

Comparable results with mainstay drug-eluting stents raise hopes for an alternative, leave-nothing-behind strategy for some patients with acute MI.
Medscape Medical News

As ER Wait Times Grow, More Patients Leave Against Medical Advice

Fri, 24 May 2019 12:44:50 +0000

In California, more than 350,000 ER visits in 2017 ended when patients left the hospital after seeing a doctor but before their medical care was complete. That was a 57% increase from 5 years earlier.
Kaiser Health News

Легкие сигареты вызывают рак легкого и убивают так же эффективно, как обычные

Fri, 24 May 2019 18:49:24 +0000

Легкие сигареты и обычные сигареты с фильтром одинаково опасны для здоровья, но сигареты без фильтра сильнее увеличивают риск смерти и развития рака легкого. Ученые сообщили о результатах своего исследования на конференции Американского торакального общества.

UN Creates New Ebola Chief Role to Tackle Security, Political Issues in Congo

Fri, 24 May 2019 11:03:36 +0000

The United Nations named an Emergency Ebola Response Coordinator on Thursday, creating a new position to boost efforts to contain a 10-month epidemic in the Democratic Republic of Congo that has killed more than 1,200 people.
Reuters Health Information

Machine-Learning Models Help Predict Remission in Crohn's

Fri, 24 May 2019 11:07:12 +0000

Machine learning models can help identify patients with Crohn's disease likely to be durable responders to ustekinumab before committing to long-term treatment, researchers report.
Reuters Health Information

E-Cigs Can Double Success Rates of Quitting Smoking, UK Study Finds

Fri, 24 May 2019 11:11:04 +0000

People using e-cigarettes to quit smoking are about 95 percent more likely to report success than those trying to quit without help from any stop-smoking aids, according to the results of a large study in England.
Reuters Health Information

Swimming, S'mores and Shots: Camps Harden Vaccine Rules in U.S. Measles Outbreak

Fri, 24 May 2019 11:35:11 +0000

As the United States battles its worst measles outbreak in 25 years, summer camps are tightening their policies on vaccines, with some prepared to turn away children whose parents opted not to vaccinate them against the disease.
Reuters Health Information

Company Charges Private Insurance Quadruple for Dialysis

Fri, 24 May 2019 11:02:49 +0000

DaVita charges four times as much for dialysis for privately insured patients in the US compared with those on government insurance; research opens discussion about wide margin in profits.
Medscape Medical News

ARTEMIS: Stop Progression to Diabetes to Avoid CV Events

Fri, 24 May 2019 11:30:48 +0000

ARTEMIS findings suggest efforts should be made to prevent progression to type 2 diabetes for patients with treated coronary artery disease and prediabetes.
Medscape Medical News

Fall Injuries Top Cause of Hospital Readmission in Elderly

Fri, 24 May 2019 10:00:33 +0000

Fall-related injuries were a top cause of hospital readmission for elderly patients, particularly those discharged home or to home care after hospitalization for a fall-related injury, a study found.
Medscape Medical News

FDA Approves First Mesothelioma Treatment in 15 Years

Fri, 24 May 2019 08:58:00 +0000

The NovoTTF-100L System is approved for use in combination with pemetrexed plus platinum-based chemotherapy in patients with malignant pleural mesothelioma.
FDA Approvals

Мозги женщин лучше работают, если в офисе тепло

Fri, 24 May 2019 14:58:32 +0000

Если женщины жалуются, что температура в офисе слишком низкая, то лучше пойти им на встречу и увеличить ее. Это поспособствует не только их личному комфорту: новое исследование, опубликованное в журнале PLOS One, показало, что умственная производительность женщин растет, когда на работе теплее.

Physicians Less Likely to Order Cancer Screening Late in Day

Fri, 24 May 2019 07:48:08 +0000

New research from the University of Pennsylvania's Nudge Unit echoes earlier studies on the effects of decision fatigue in medicine.
Medscape Medical News

[Health Policy] Challenges for immigrant health in the USA—the road to crisis

Thu, 23 May 2019 23:00:09 +0000

The USA is home to more immigrants than any other country—about 46 million, just less than a fifth of the world's immigrants. Immigrant health and access to health care in the USA varies widely by ethnicity, citizenship, and legal status. In recent decades, several policy and regulatory changes have worsened health-care quality and access for immigrant populations. These changes include restrictions on access to public health insurance programmes, rhetoric discouraging the use of social services, aggressive immigration enforcement activities, intimidation within health-care settings, decreased caps on the number of admitted refugees, and rescission of protections from deportation.

[Review] The rise and fall of aspirin in the primary prevention of cardiovascular disease

Thu, 23 May 2019 23:00:09 +0000

Aspirin is one of the most frequently used drugs worldwide and is generally considered effective for the secondary prevention of cardiovascular disease. By contrast, the role of aspirin in primary prevention of cardiovascular disease is controversial. Early trials evaluating aspirin for primary prevention, done before the turn of the millennium, suggested reductions in myocardial infarction and stroke (although not mortality), and an increased risk of bleeding. In an effort to balance the risks and benefits of aspirin, international guidelines on primary prevention of cardiovascular disease have typically recommended aspirin only when a substantial 10-year risk of cardiovascular events exists.

[Clinical Picture] Dog licks baby. Baby gets Pasteurella multocida meningitis

Thu, 23 May 2019 23:00:09 +0000

A 12-day-old baby was admitted to our hospital with a fever, irritability, and poor feeding. His temperature was 39° C. On physical examination, he was irritable but consolable. His anterior fontanelle was full but not bulging. Laboratory tests included a complete blood cell count, which showed a white blood cell count of 4·8 × 109 per L, with 72% neutrophils. Analysis of the infant's cerebrospinal fluid (CSF) showed 3 050 white blood cells per μL, with 94% neutrophils, protein concentration was 110 mg/dL, and glucose concentration 49 mg/dL (normal 60–80).

[Articles] Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study

Thu, 23 May 2019 23:00:09 +0000

Introduction of PCV10 in Kenya, accompanied by a catch-up campaign, resulted in a substantial reduction in PCV10-type IPD in children and adults without significant replacement disease. Although the catch-up campaign is likely to have brought forward the benefits by several years, the study suggests that routine infant PCV10 immunisation programmes will provide substantial direct and indirect protection in low-income settings in tropical Africa.

[Articles] Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial

Thu, 23 May 2019 23:00:09 +0000

Levetiracetam is not superior to phenytoin for second-line management of paediatric convulsive status epilepticus.

[Articles] Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Thu, 23 May 2019 23:00:09 +0000

Although levetiracetam was not significantly superior to phenytoin, the results, together with previously reported safety profiles and comparative ease of administration of levetiracetam, suggest it could be an appropriate alternative to phenytoin as the first-choice, second-line anticonvulsant in the treatment of paediatric convulsive status epilepticus.

[Department of Error] Department of Error

Thu, 23 May 2019 23:00:09 +0000

Danaei G, Farzadfar F, Kelishadi R, et al. Iran in transition. Lancet 2019; 393: 1984–2005—In this Review, the Acknowledgments section has been updated with the following addition: “The authors alone are responsible for the views expressed in this Review, and they do not necessarily represent the views, decisions, or policies of their institutions.” This correction has been made to the online version as of May 23, 2019.

[Department of Error] Department of Error

Thu, 23 May 2019 23:00:09 +0000

Makoni M. Health under the spotlight as South Africa takes to the polls. Lancet 2019; 393: 1791–92—In this World Report, contributor quotes were mistakenly attributed to Kate Ribet, Médecins Sans Frontières (MSF) communications manager, when they should have been attributed to MSF Regional Migration Coordinator Liesbeth Schockaert. This correction has been made to the online version as of May 23, 2019.

[Department of Error] Department of Error

Thu, 23 May 2019 23:00:09 +0000

Holt E. US FDA rules manufacturers to stop selling mesh devices. Lancet 2019; 393: 1686—In this World Report, contributor Elizabeth Kavaler's name was misspelt. This correction has been made to the online version as of May 23, 2019.

[Correspondence] Response to critique of review of The Big Fat Surprise

Thu, 23 May 2019 23:00:09 +0000

Henry Blackburn and colleagues,1 the active leaders of the Seven Countries Study (SCS), criticise a review2 of my book, The Big Fat Surprise,3 for not being sufficiently skeptical. However, several of the authors' critiques are not supported by the evidence.

[Correspondence] Early detection of HPV-associated oropharyngeal cancer

Thu, 23 May 2019 23:00:09 +0000

We read with interest the letter by Gilliam Prue and colleagues,1 stating the need for the urgent introduction of gender-neutral HPV vaccination in the UK. Although we agree with the authors' economic analysis of the situation, we would also like to draw attention to the potential future costs to UK society in general.

[Correspondence] Establishment of women-specific hospitals in Iran

Thu, 23 May 2019 23:00:09 +0000

Providing medical services to women by women was introduced after Iran's Islamic revolution. The revolution resulted in the formation of an Islamic republic. The Supreme Leader ordered exclusive admission to women for the training of obstetrics and gynaecology in the early 1980s.1 In 1998, the Iranian Ministry of Health and Medical Education was in charge of adjusting its services in line with Islamic rules, which is known as the gender conformity plan (GCP).2

[Correspondence] Hope for female scientists in Yemen

Thu, 23 May 2019 23:00:09 +0000

Fathiah Zakham and Katia Juton1 beautifully associated past and present in Yemen, and, despite the current difficulties due to continuing war and instability, their highlighting of success stories managed by contemporary Yemeni women brings optimism and hope. I thank The Lancet for recognising pioneering women in science from all over the world.

[Correspondence] Women in Surgery Africa and research

Thu, 23 May 2019 23:00:09 +0000

The Editors1 noted the need to support scholarship from the Global South. Women in Surgery Africa (WiSA) agrees.

[Correspondence] Retention of female surgeons in training

Thu, 23 May 2019 23:00:09 +0000

In their qualitative study, Rhea Liang and colleagues1 identified factors, including the inability to take leave, poor mental health, inadequate support, and fear of repercussion, which led to attrition of women in surgical training. Other factors identified in previous quantitative studies include insufficient role models and institutional support, gender discrimination and harassment, sleep deprivation, adverse interaction with seniors, pregnancy and childbirth, and childrearing duties.2 As a surgical educator for more than two decades, and as a father of two daughters currently in general surgical training in the UK, I fully acknowledge the factors influencing women in surgical training.

[Correspondence] Epidemiology needs to embrace gender

Thu, 23 May 2019 23:00:09 +0000

Cheryl Pritlove and colleagues1 comment on implicit bias and raise important issues about the place of women in science. We argue that their recommendations also apply to the conduct of health research itself. Tackling individual and structural implicit bias means not only increasing diversity among researchers and focusing more on gender minorities topic-wise (understanding minority in a political, not numerical, sense), but also thinking radically differently about it, deconstructing assumptions to better measure the gender-related social determinants of health.

[Correspondence] All of women's health needs are worthy of attention

Thu, 23 May 2019 23:00:09 +0000

The theme issue on advancing women in science, medicine, and global health illuminated crucial problems about gender equity, noting that although sex-disaggregated data are increasingly reported, such studies are more likely to have female first or last authors and to be published in journals of low impact.1 Further, gender gaps persist in grant funding, with less favourable assessments of female principal investigators.2 Thus, women who elevate knowledge about their sex by conducting and reporting research are penalised.

[Obituary] Helen Mary Warnock

Thu, 23 May 2019 23:00:08 +0000

Philosopher whose report created a framework for embryo research. Born in Winchester, UK, on April 14, 1924, she died after a fall at home in Wiltshire on March 20, 2019, aged 94 years.

[Perspectives] Insulin for all: treatment activism and the global diabetes crisis

Thu, 23 May 2019 23:00:08 +0000

In 2 years, the world will celebrate the centenary of the discovery of insulin for the treatment of diabetes. An estimated 20–40 million people worldwide require this essential medicine for survival. This includes all patients with type 1 diabetes who depend on exogenous insulin for normal metabolism and people with type 2 diabetes who have become desensitised to their own endogenous insulin. Yet nearly a century after the discovery of this lifesaving drug, there are many premature and preventable deaths due to the lack of accessible, affordable insulin products.

[Perspectives] Kelsey Hegarty: calling attention to domestic violence

Thu, 23 May 2019 23:00:08 +0000

Kelsey Hegarty knew she wanted to be a rural family doctor in her native Queensland, having studied medicine at the University of Queensland in Brisbane, Australia. She had no idea then that as well as becoming a general practitioner (GP), she would end up helping families in a different way, by studying the impact of interventions for domestic violence. Today, she is the joint Chair in Family Violence Prevention at the University of Melbourne and the Royal Women's Hospital in Melbourne, VIC, Australia.

[Perspectives] Institutional madness: Shakespeare as hospital survival guide

Thu, 23 May 2019 23:00:08 +0000

What if we took literally Susan Sontag's familiar metaphor that “everyone who is born holds dual citizenship, in the kingdom of the well and in the kingdom of the sick”? Then we would recognise that illness involves literal travel to other places, kingdoms governed by different authorities who enforce rules quite different from those that govern the kingdom of the well. These rules are more than different; they can be bizarre or irrational. Those who do their daily work in these kingdoms may be resigned to them.

[Perspectives] Depression

Thu, 23 May 2019 23:00:08 +0000

Meteorology, economics, and geology—all have their depressions. Mid-19th century laboratory physiologists also spoke of depression—a decline in the biochemical output of an organ—and this usage, with its connotations of functional materialism, haunts the contemporary concept of depression. As the physician and historian Laura D Hirshbein argues, depression is “a twentieth-century phenomenon that incorporates assumptions about gender, profession, and science”, reflecting the shifting balance of power between theories, therapies, and patients' experiences.

[Perspectives] The power of sympathy groups

Thu, 23 May 2019 23:00:08 +0000

The other day I received a message from a young relative who has been exploring a strange new land, what Susan Sontag famously described, in Illness as Metaphor, as the kingdom of the sick. The message read, “Having a can't-get-out-of-bed day today. Finding comfort in cardiomyopathy support groups on Facebook!” These social-media groups are similar to face-to-face “sympathy groups”, the subject of Anthony Costello's The Social Edge: The Power of Sympathy Groups for Our Health, Wealth and Sustainable Future.

[World Report] NGOs push for decentralised Ebola treatment in DR Congo

Thu, 23 May 2019 23:00:08 +0000

The initiative, led by MSF and ALIMA, would provide community-based Ebola virus disease care. But pushback from DR Congo Ministry of Health could prove difficult. Miriam Shuchman reports.

[Comment] Offline: A story of discrimination against women

Thu, 23 May 2019 23:00:08 +0000

Utako Okamoto (1918–2016) is not a name widely known, let alone celebrated, in medicine and global health. Yet this remarkable Japanese scientist deserves international recognition for her heroic struggle to advance women's and children's health. She discovered the drug tranexamic acid in the 1950s and believed that its powerful haemostatic properties might offer decisive benefits for women who suffered post-partum haemorrhage. Ian Roberts, in his inaugural UK Faculty of Public Health Bazalgette Lecture delivered last week in London, described the story of a medical scientist with an astonishing vision.

[Comment] Retraction—A check-up on Canada's health system

Thu, 23 May 2019 23:00:08 +0000

On Nov 25, 2017, The Lancet published a book review of Danielle Martin's Better Now: Six Big Ideas to Improve Health Care for All Canadians by Kishor M Wasan, Ellen K Wasan, and Jawahar Kalra.1 In February, 2019, we learned that substantial passages in this book review match parts of a review of the same book by André Picard published in January, 2017.2 We are therefore retracting this book review and the payment for the review has been returned.

[Comment] A Lancet Commission to address the global burden of hearing loss

Thu, 23 May 2019 23:00:08 +0000

To mark World Hearing Day for 2019, we are pleased to announce a Lancet Commission to identify ways to reduce the global burden of hearing loss. The Commission follows a recent Lancet Review of the state of global hearing health care and possibilities for improving it.1As noted in the Review, hearing loss was the fourth leading cause of years lived with disability (YLDs) worldwide in 2015, representing 5·8% of YLDs due to all causes. Additionally, in 2015, half a billion people worldwide had a disabling hearing loss and 1·34 billion had a mild-to-complete hearing loss in the better-hearing ear—6·8% and 18·1% of the world's population, respectively.

[Comment] Sham trials: benefits and risks for cardiovascular research and patients

Thu, 23 May 2019 23:00:08 +0000

Randomised, double-blind, placebo-controlled trials are considered the gold standard to evaluate efficacy and safety of new therapies. The reason behind blinding and placebo control is to minimise bias while balancing potential placebo effects. In the case of interventional procedures, the term placebo is replaced by sham procedures. Despite limited precedents, sham-controlled studies are becoming an expected norm for regulatory approval of new medical device therapies in certain therapeutic fields, of which hypertension is a central example.

[Comment] Population versus individual protection by pneumococcal conjugate vaccination

Thu, 23 May 2019 23:00:08 +0000

In The Lancet, Laura Hammitt and colleagues1 describe a reduction of pneumococcal disease burden in all ages by childhood immunisation with ten-valent pneumococcal conjugate vaccine (PCV) in Kenya, a low-income country (LIC), which adds to the body of evidence for this effect, which is well described to date only in high-income2 and middle-income3 countries.

[Comment] Levetiracetam no better than phenytoin in children with convulsive status epilepticus

Thu, 23 May 2019 23:00:08 +0000

Although frightening to watch, most generalised convulsive seizures in both adults and children stop within about 2 min with or without treatment. Seizures that last more than 5 min, however, usually do not stop without anticonvulsant treatment. Initial treatment for these patients in status epilepticus is rapidly and adequately dosed administration of a benzodiazepine. Guidelines for benzodiazepine dosing are based on high-quality data from randomised controlled trials.1–3 Status epilepticus, treated according to guidelines, can be expected to resolve in about 70% of patients after first-line treatment with benzodiazepines.

[Editorial] Confronting heart disease and health inequality in the UK

Thu, 23 May 2019 23:00:08 +0000

A surprising increase in cardiovascular disease deaths in the UK among people aged 75 years and younger was announced by the British Heart Foundation on May 13, the first such rise in half a century. 42 384 deaths were reported in 2017, compared with 41 042 in 2014, with a similar trend for deaths under 65 years of age—a 4% increase in deaths in the past 5 years, compared with a 19% decline for the preceding 5-year period. The causes of this reversal are doubtless complex, but remain unknown. A Review of aspirin's role in cardiovascular medicine in this week's issue is therefore timely.

[Editorial] Acknowledging the limits of public health solutions

Thu, 23 May 2019 23:00:08 +0000

The Ebola virus disease outbreak in DR Congo has taken an alarming turn. Between April 22 and May 12, 343 confirmed cases were reported, taking the total number to 1738 as of May 19. Despite this rapid and unprecedented deterioration, WHO has not declared the outbreak a Public Health Emergency of International Concern (PHEIC). Although calls to declare a PHEIC are understandable in the face of a worsening and precarious situation, such a declaration, and the increased technical response that it entails, will do little to address what is principally a political problem.

[Editorial] We must all support women in the fight for abortion

Thu, 23 May 2019 23:00:08 +0000

On May 15, 2019, the Alabama State Senate passed a bill that restricts the right to abortion by criminalising doctors who do the procedure. This was followed the next day by the Missouri State Senate passing a law forbidding abortions after 8 weeks of pregnancy. These two bills are the latest in a rapidly escalating attack on a woman's constitutionally protected right to an abortion. Alabama, Georgia, Mississippi, and Ohio have all already successfully passed legislation banning abortion after 6 weeks of pregnancy this year.

Loneliness Common in Urban-Dwelling, Mid-Aged Women

Thu, 23 May 2019 18:33:15 +0000

Caregiver responsibilities and relationships of poor quality are contributors to severe loneliness in urban women, but supportive relationships may be a protective factor, new research suggests.
Medscape Medical News

Cerebral Microbleeds Should Not Deter Antithrombotics in Stroke

Thu, 23 May 2019 16:51:44 +0000

The absolute risk for ischemic stroke was consistently higher than the absolute risk for ICH regardless of microbleed burden, a new pooled analysis found.
Medscape Medical News

FDA Clears First Zika Blood Test for Routine Use

Thu, 23 May 2019 17:10:26 +0000

The ZIKV Detect 2.0 IgM Capture ELISA had previously been authorized only for emergency use under the FDA's emergency use authorization authority.
FDA Approvals

Half of US States Now Report Measles Cases

Thu, 23 May 2019 17:25:07 +0000

With Maine reporting its first confirmed case of measles on May 20, half of US states have now been hit with the highly contagious infection.
Medscape Medical News

FDA Issues Class l Recall of Three Blood Test Analyzers

Thu, 23 May 2019 17:49:30 +0000

The agency alerted hospitals, labs, and other providers after recurring complaints of inaccurate platelet counts with three Beckman Coulter models. More than 2000 labs in the US may be affected.
News Alerts

Estrogen a Possible Treatment Option for Schizophrenia?

Thu, 23 May 2019 16:20:13 +0000

Adjunctive estrogen significantly reduces schizophrenia symptoms in women in a dose-dependent manner and offers patients a potential new treatment option, new research suggests.
Medscape Medical News

Gratitude Journaling Boosts Wellness in Psychiatry Residents

Thu, 23 May 2019 16:36:31 +0000

Gratitude journaling can improve quality of life by boosting feelings of well-being among psychiatry residents, but getting residents to stick to it is a challenge.
Medscape Medical News

Public Reporting of PCI Outcomes: High Costs and Physician Burden

Thu, 23 May 2019 15:17:28 +0000

Survey highlights costs imposed by state-mandated reporting in Massachusetts, but much of the time spent is actually for NCDR requirements, according to advocates of public reporting.
Medscape Medical News

FDA Clears Assays for Extragenital Chlamydia/Gonorrhea Testing

Thu, 23 May 2019 15:43:18 +0000

The Aptima Combo 2 Assay and the Xpert CT/NG are the first tests cleared for diagnostic testing for Chlamydia and gonorrhea via throat and rectal samples.
FDA Approvals

IBM, Cera Care to Test Self-Driving Car Tech in Elder Homes

Thu, 23 May 2019 14:44:55 +0000

IBM and British start-up Cera Care plan a six-month pilot to test whether lidar laser sensors, used to help self-driving cars "see," can enable elderly people to stay in their homes for longer - without compromising privacy.
Reuters Health Information

Brazil Sues Top Tobacco Firms to Recover Public Health Costs

Thu, 23 May 2019 14:40:37 +0000

Brazil's solicitor general's office is suing the world's largest cigarette makers British American Tobacco Plc and Philip Morris International to recover the public health treatment costs of tobacco-related diseases over the last five years.
Reuters Health Information

Congo Wants More Use of Merck Vaccine Rather Than J&J Newcomer - Minister

Thu, 23 May 2019 13:59:13 +0000

Democratic Republic of Congo called on Wednesday for Merck's experimental Ebola vaccine to be fully licensed to facilitate its use in the Ebola-hit country, while saying Johnson & Johnson's rival drug would complicate matters.
Reuters Health Information

Oncology Care Providers Do Discuss Lifestyle With Patients

Thu, 23 May 2019 13:52:58 +0000

Oncologists and related professionals report counseling patients on weight loss, diet, and exercise, but few report making referrals to support lifestyle changes.
Medscape Medical News

Registry Outcomes Support Sirolimus-Eluting Stent

Thu, 23 May 2019 13:54:09 +0000

Compared with other frequently used newer-generation drug-eluting stents, the ultra-thin sirolimus-eluting device was associated with lower target lesion revascularization rates, new registry data suggest.
Medscape Medical News

Asbestos: A Public Health Crisis of 'Unprecedented Scale'

Thu, 23 May 2019 13:03:38 +0000

Dramatic increases in mesothelioma and other asbestos-related cancers and lung diseases are expected to continue for decades in developing countries.
Medscape Medical News

Restarting Antiplatelet After ICH Cuts Recurrence Risk in Half

Thu, 23 May 2019 11:59:26 +0000

Restarting antiplatelet therapy after intracranial hemorrhage remains controversial, but new evidence suggests aspirin or clopidogrel can significantly reduce recurrent ICH without increased bleeding.
Medscape Medical News

Psychedelic Cuts Cravings, Consumption in Alcohol Use Disorder

Thu, 23 May 2019 12:07:01 +0000

Preliminary study results are promising, and the study represents a new wave of research into psychedelic drugs and various psychiatric conditions.
Medscape Medical News

Daily Self Weigh-in and Tracking Prevents Holiday Excess

Thu, 23 May 2019 12:46:36 +0000

Daily weighing linked to a feedback app helped people avoid piling on the pounds over the holiday season (Thanksgiving to New Year's Day). Those who didn't do this gained an average of 2.65 kg (6 Ib).
Medscape Medical News

Физические упражнения могут стать основным лечением некоторых психических болезней

Thu, 23 May 2019 18:34:56 +0000

Исследователи из Медицинского центра при Вермонтском университете рекомендуют физическую активность, а не психотропные препараты, в качестве основного предписания и метода вмешательства при стационарном лечении ряда психических расстройств и расстройств настроения (от тревожности и депрессии до шизофрении, суицидальности и острых психотических эпизодов).

Огромное количество случаев рака можно объяснить плохим питанием

Thu, 23 May 2019 18:40:36 +0000

Наибольшее число случаев рака, связанных с неправильным питанием, пришлось на рак толстой и прямой кишки (38,3%). За ним следуют рак ротовой полости, глотки и гортани, рак матки, рак молочной железы в постменопаузе, рак почки, рак желудка и рак печени.

Prevalence of Perinatal Depression Significantly Underestimated?

Thu, 23 May 2019 10:22:09 +0000

A free mobile app that screens for perinatal depression suggests the prevalence of the disorder is significantly underestimated.
Medscape Medical News

Guidance Updated for Sports Physicals

Thu, 23 May 2019 09:28:47 +0000

Updated guidance for the preparticipation physical evaluation (sports physical) includes evaluating the mental health of students and provides new information on female and transgender athletes.
Medscape Medical News

Steroids Not Effective for Mild, Low-Eosinophil Asthma

Thu, 23 May 2019 08:21:55 +0000

For patients with mild, persistent asthma and low levels of eosinophils, responses to two steroids were no better than response to placebo, new research shows.
Medscape Medical News

California Poised to Extend Medicaid to Undocumented Immigrants

Thu, 23 May 2019 07:23:12 +0000

The governor proposes enrolling young adults only. Other bills would cover all undocumented immigrants who qualify for Medi-Cal.
Medscape Medical News

Рецепты солнцезащитных кремов, найденные в интернете, грозят ожогами кожи

Thu, 23 May 2019 08:25:05 +0000

Если вы действительно хотите уберечься от солнца, то не следует доверять самодельным солнцезащитным кремам. В ходе недавнего исследования, проведенного учеными из Национальной детской больницы штата Огайо, были изучены рецепты самодельных солнцезащитных кремов, опубликованные на популярном веб-сайте Pinterest.

Holding PCPs Accountable for Readmissions May Be Misguided

Wed, 22 May 2019 19:05:37 +0000

Readmission rates varied very little between individual primary care physicians so rewards for changing practice may not make sense, a study found.
Medscape Medical News

FDA Approves Calcipotriene for Plaque Psoriasis in Adolescents

Wed, 22 May 2019 18:13:27 +0000

The US Food and Drug Administration approved calcipotriene foam (Sorilux) for the treatment of plaque psoriasis of the scalp and body in adolescents aged 12 years or older.
FDA Approvals

Meta-analysis Confirms Late Thrombolysis Benefits in Stroke

Wed, 22 May 2019 17:10:27 +0000

Further results have confirmed the benefit of thrombolysis up to 9 hours after onset of ischemic stroke in patients with salvageable brain tissue identified by mismatch on CT perfusion imaging.
Medscape Medical News

PCR Stands Firm Behind Paclitaxel-Coated Devices in PAD

Wed, 22 May 2019 17:18:48 +0000

Although other societies and the FDA have advised physicians to consider alternative treatment options because of a potential late mortality signal, PCR says not so fast.
Medscape Medical News

Flash Glucose Monitoring Helps Control Type 2 Diabetes

Wed, 22 May 2019 16:52:14 +0000

A flash glucose monitoring (FGM) system, the FreeStyle Libre from Abbott, helps achieve significant hemoglobin (Hb)A1c reductions in patients with type 2 diabetes using insulin, and may improve satisfaction, according to a company-funded study.
Reuters Health Information

Improved Air Quality Tied to Fewer New Childhood Asthma Cases

Wed, 22 May 2019 16:43:27 +0000

Childhood asthma rates appear to be dropping in many communities across southern California, and a new study suggests this may be due at least in part to improved air quality.
Reuters Health Information

U.S. States, Cities Sue to Block Trump 'Conscience' Rule for Healthcare Workers

Wed, 22 May 2019 16:32:38 +0000

A coalition of 23 U.S. states and municipalities sued the Trump administration on Tuesday to stop it from enforcing a rule that would make it easier for doctors and nurses to avoid performing abortions on religious or moral grounds.
Reuters Health Information

Even Doctors Can't Navigate Our 'Broken Health Care System'

Wed, 22 May 2019 16:00:25 +0000

Social media outlets like Twitter and Facebook are a powerful new avenue for people to seek redress for health care grievances. One doctor, angry at the care being shown for his father, did just that.
Kaiser Health News

Improper Proton Pump Inhibitor Prescriptions Criticized

Wed, 22 May 2019 15:05:26 +0000

Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.
Medscape Medical News

OTC Hearing Aids: Useful Lower-Cost Option for Some Patients

Wed, 22 May 2019 15:25:17 +0000

According to a recent study, over-the-counter hearing devices may be effective, lower-cost alternatives to hearing aids for adults with mild to moderate hearing loss.
Medscape Medical News

High 30-Day Residual MR Augurs Worse Outcomes in COAPT

Wed, 22 May 2019 15:38:20 +0000

Patients with residual mitral regurgitation greater than 2+ had significantly higher rates of heart failure hospitalization and all-cause mortality, regardless of treatment type.
Medscape Medical News

Tricuspid Regurgitation Clipping Takes Promising First Step

Wed, 22 May 2019 13:56:47 +0000

The investigational TriClip device looks to build on successes in the mitral valve space in the often overlooked and challenging tricuspid valve.
Medscape Medical News

Cancer Now Accounts for 1 in 3 Deaths; Prevention Is Key

Wed, 22 May 2019 14:05:17 +0000

Cancer is now the leading cause of death in Canada, and abdominal adiposity is set to become the second leading preventable cause of cancer by 2042.
Medscape Medical News

Gastric Bypass Ups Fracture Risk, Need for Long-term Management

Wed, 22 May 2019 11:59:25 +0000

Although gastric bypass surgery is linked to 'myriad health benefits' for those with obesity, an increased fracture risk 'is an important factor to discuss with patients,' says the lead author of new study.
Medscape Medical News

Childhood Asthma May Begin Before Birth

Wed, 22 May 2019 12:15:13 +0000

The microbiome of newborns, which can be affected by mode of delivery and alters again with feeding after birth, could predict wheezing later in life, new research shows.
Medscape Medical News

FDA Warns Against Off-Indication Use of Abiomed Impella RP System

Tue, 21 May 2019 14:55:52 +0000

FDA Warns Against Off-Indication Use of Abiomed Impella RP System
News Alerts

Неправильное использование детских автокресел делает сон в них смертельно опасным

Wed, 22 May 2019 17:36:42 +0000

Дети, спящие в автомобильных креслах дома, могут упасть на твердую поверхность или перевернуться на мягкую поверхность и задохнуться. Также ученые обнаружили, что к смерти может привести и неправильная застежка ремней на сиденье.

'Game Changer' for Schizophrenia on the Horizon?

Wed, 22 May 2019 10:04:35 +0000

A potentially first-in-class psychotropic agent for schizophrenia that does not work through dopamine gets breakthrough therapy designation from the US Food and Drug Administration.
Medscape Medical News

FDA Issues Guidance for Industry Assessing Reproductive Toxicity

Wed, 22 May 2019 10:37:52 +0000

The FDA has issued new guidance for industry on assessing reproductive toxicity for anticancer pharmaceuticals and makes recommendations for pharmaceutical labeling.
Medscape Medical News

Ученые: Если ребенок глотнул батарейку, ее нужно извлекать даже при отсутствии симптомов

Wed, 22 May 2019 16:33:40 +0000

Глотание детьми миниатюрных батареек («таблеток») может привести к быстрому повреждению слизистой оболочки желудка. Поэтому врачам необходимо рассматривать вопрос об оперативном эндоскопическом удалении, даже если у ребенка отсутствуют симптомы и батарейка благополучно прошла через узкий пищевод.

Do You Recommend a Ketogenic Diet to Your Patients?

Wed, 22 May 2019 08:54:45 +0000

Recent studies suggest benefits and risks to the popular low-carb diet.
Medscape Reader Polls

Cerebral Hyperperfusion After Carotid Stenting: Who Is at Risk?

Wed, 22 May 2019 09:28:49 +0000

A new prospective study of this rare but severe complication finds female sex, older age, and history of kidney disease ups the risk.
Medscape Medical News

Stopping bDMARDs Before RA Hip, Knee Arthroplasty Questioned

Wed, 22 May 2019 08:02:39 +0000

Postarthroplasty infection risk in those with rheumatoid arthritis was higher after even modest preoperative doses of glucocorticoids. No difference in infection risk was detected among biologic therapies.
Medscape Medical News

Former Ohio State Team Doctor Sexually Abused at Least 177

Wed, 22 May 2019 06:56:52 +0000

A yearlong investigation concluded that the university knew of complaints as early as 1979 but allowed Richard Strauss to stay until 1998, when he retired with emeritus status.
Medscape Medical News

Ученые подтвердили важность социальных факторов в развитии диабета и гипертонии

Wed, 22 May 2019 13:25:27 +0000

Определенные социальные и поведенческие факторы риска коррелируют с ранним развитием артериальной гипертонии и сахарного диабета. Это касается проживания в бедном районе, низкого уровня образованности, денежных и некоторых других проблем.

Doctors, Patients Struggle With Benzodiazepine Use

Tue, 21 May 2019 22:21:23 +0000

Addiction specialists say more people are becoming dependent on a class of drug that's hard to give up and doesn't play well with others.
WebMD Health News

ICH Risk Increased With Low-Dose Aspirin in Primary Prevention

Tue, 21 May 2019 16:18:23 +0000

The benefits of low-dose aspirin in symptomatic CVD are established, but any benefit does not outweigh the risk of intracranial hemorrhage in people without CVD, researchers say.
Medscape Medical News

Guidelines Addressing Physician Sexual Abuse Long Past Due

Tue, 21 May 2019 16:26:05 +0000

As other industries take action against sexual abuse, it's long past time for the healthcare industry to step up and implement interventions to do the same, authors of a new article argue.
Medscape Medical News

Experts Go Toe-to-Toe Over Esketamine Depression Study

Tue, 21 May 2019 16:50:05 +0000

The ongoing debate over the risks and benefits of recently approved esketamine nasal spray for treatment-resistant depression spilled over into a heated discussion at the APA 2019 Annual Meeting.
Medscape Medical News

Опубликовано исследование, подтверждающее эффективность спрея кетамина при депрессии

Tue, 21 May 2019 22:14:35 +0000

Новое исследование подтверждает эффективность и безопасность назального спрея эскетамина (S-кетамина) при лечении депрессии у людей, которым не помогло лечение другими средствами. Научная работа опубликована в American Journal of Psychiatry.

Doctors to End Care for French Patient in Landmark Right-to-Die Case

Tue, 21 May 2019 15:39:39 +0000

Doctors treating French quadriplegic Vincent Lambert, who has been in a deep vegetative state for more than a decade, plan to stop feeding him this week, renewing a furious debate over the right-to-die that has split France and Lambert's family.
Reuters Health Information

FDA Warns of Increased Mortality With Abiomed Impella RP

Tue, 21 May 2019 14:55:52 +0000

A letter to healthcare providers says the increased risk is mostly among those who would not have qualified for premarket approval studies, and it recommends sticking to the approved indication.
News Alerts

Электронные сигареты могут увеличивать восприимчивость к респрираторным инфекциям

Tue, 21 May 2019 20:08:55 +0000

О том, что курение является фактором, который увеличивает тяжесть гриппа, известно сравнительно давно. Сейчас ученые сообщают, что использование электронных сигарет приводит к подобным проблемам: вейпинг снижает способность организма сопротивляться вирусу гриппа.

Small Vessel TLR Rate Lower at 3 Years With Sirolimus-Eluting Stent

Tue, 21 May 2019 13:22:38 +0000

Other components of the primary composite end point of target lesion failure did not differ among the three stents tested in the BIO-RESORT trial.
Medscape Medical News

NIH Suspended Some Grants to Duke Amid Concern for Patient Safety

Tue, 21 May 2019 13:25:04 +0000

Case followed misconduct finding in oncology research, and lung research that led to $112.5 million settlement with the US government.
Medscape Medical News

Mediterranean Diet May Keep Late-Life Depression at Bay

Tue, 21 May 2019 12:18:30 +0000

Adherence to a Mediterranean diet may guard against late-life depression, new research shows.
Medscape Medical News

CBD Offers 'Significant Promise' for Heroin Addiction

Tue, 21 May 2019 12:34:32 +0000

Oral cannabidiol reduces cue-induced drug craving and anxiety and may be a good non-opioid treatment option for opioid use disorder, say authors of a new study.
Medscape Medical News

Body Adiposity, Not BMI, Key to CV Risk in Colorectal Cancer

Tue, 21 May 2019 11:33:20 +0000

"One of the exciting developments is there are now automated techniques that can precisely quantify the amount of muscle and fat from CT images." — Justin Brown, Pennington Biomedical Research Center.
Medscape Medical News

6-Hour Intervention Steers More Med Students to Psychiatry

Tue, 21 May 2019 08:18:04 +0000

A brief intervention aimed at medical students reduces stigma and improves attitudes toward mental illness, and prompts more to consider psychiatry as a career.
Medscape Medical News

What's Happening at ASCO 2019?

Tue, 21 May 2019 08:48:58 +0000

The largest meeting in the oncology world is taking place in Chicago yet again, but this year some novel topics are in the spotlight, as well as the usual clinical data.
Medscape Medical News

CBD Gel Promising for Fragile X Syndrome

Tue, 21 May 2019 07:05:34 +0000

A clear transdermal cannabidiol (CBD) gel improved emotional and behavioral symptoms in children and adolescents with fragile X syndrome and was well tolerated in a phase 2 study.
Medscape Medical News

Measles Cases Highest Since 1994, Now in 24 States, CDC Says

Mon, 20 May 2019 17:45:34 +0000

The number of confirmed measles cases in the United States rose by 41 in the past week, to 880 cases from January 1 to May 17, 2019 — the highest since 1994.
Medscape Medical News

Long-term Data Reveal Health Fallout for Children of 9/11

Mon, 20 May 2019 17:49:42 +0000

Children who were directly exposed experience separation anxiety, panic disorder, marijuana use and other psychiatric and physical conditions compared to unexposed children.
Medscape Medical News

Ban 'Reprocessing' of Spinal Surgery Screws, Experts Say

Mon, 20 May 2019 16:05:12 +0000

As mounting research shows that the practice of 'reprocessing' spinal surgery screws leads to contamination, some countries are outlawing them, but the US appears to be foot-dragging.
Medscape Medical News

Highly Processed Food Intake Leads to Overeating and Weight Gain

Mon, 20 May 2019 16:10:13 +0000

The first randomized controlled trial to demonstrate that a diet high in ultra-processed foods leads to greater calorie intake and weight gain has been published, albeit in a tiny number of volunteers.
Medscape Medical News

Anxiety in America Still High: Top Nationwide Worries Revealed

Mon, 20 May 2019 16:29:15 +0000

A nationwide survey shows two thirds of Americans are extremely or somewhat anxious about keeping themselves and their family safe, paying bills, and maintaining their health.
Medscape Medical News

Out-of-Pocket Costs for MS, Other Neurology Meds, Soar

Mon, 20 May 2019 15:00:44 +0000

Out-of-pocket costs for drugs used to treat neurologic diseases have increased sharply over the past 13 years, including a 20-fold increase for MS medications.
Medscape Medical News

Targeting Inflammation May Help Bipolar Depression Subtype

Mon, 20 May 2019 14:12:09 +0000

The anti-inflammatory agent infliximab may improve depressive symptoms in patients with bipolar depression and a history of childhood trauma.
Medscape Medical News

Benzodiazepine Use in Early Pregnancy Tied to Miscarriage

Mon, 20 May 2019 13:16:09 +0000

Use of any benzodiazepine during early pregnancy is associated with a dramatic increase in miscarriage risk.
Medscape Medical News

Fighting Superbugs With Multipronged Pushback

Mon, 20 May 2019 13:16:42 +0000

As drug-resistant bacteria become prevalent, healthcare providers need strategies for keeping patients safe, as 2 million people in the United States are infected and 23,000 people die each year.
Medscape Medical News

FDA OKs Midazolam Nasal Spray (Nayzilam) for Seizure Clusters

Mon, 20 May 2019 13:49:41 +0000

Nayzilam is the first FDA-approved nasal option for treating seizure clusters that are distinct from a patient's usual seizure pattern in patients aged 12 years or older.
FDA Approvals

Targeting Vasopressin May Improve Social Deficits in Autism

Mon, 20 May 2019 12:03:20 +0000

There are currently no medications to address social deficits in autism, but two new studies suggest that vasopressin, a hormone associated with social bonding, may be a viable target for drug development.
Medscape Medical News

Early Death in BPD Patients Not Just Because of Suicide

Mon, 20 May 2019 12:27:25 +0000

Individuals with borderline personality disorder are at high risk of premature death not only from suicide but from other causes, including accidents, results of a randomized trial show.
Medscape Medical News

Surgical Teamwork Essential, Underappreciated

Mon, 20 May 2019 12:46:48 +0000

Surgical teams are more successful when they have experienced nurses and scrubs working together, but general surgeons are too often working without the support they need, according to new research.
Medscape Medical News

Всего одна неделя ограничения экранного времени обращает вспять вредные эффекты гаджетов

Mon, 20 May 2019 17:44:55 +0000

Простое ограничение использования гаджетов в вечернее время помогает улучшить качество сна подростков и уменьшить симптомы усталости, недостатка концентрации и плохого настроения всего лишь за одну неделю.

Extreme Weather a Disaster for Mental Health

Mon, 20 May 2019 11:10:15 +0000

There is a compelling need to better anticipate and prepare for the psychological consequences of increasingly dangerous extreme weather events caused by climate change, researchers say.
Medscape Medical News

One Bronchial Thermoplasty Treatment Beats Three for Asthma

Mon, 20 May 2019 11:16:32 +0000

Bronchial thermoplasty that targets the six most affected airways in patients with uncontrolled asthma is more effective than the standard therapy that involves three sessions, new research shows.
Medscape Medical News

Lenalidomide Delays Onset of Multiple Myeloma

Mon, 20 May 2019 10:02:44 +0000

In patients with both high-risk and intermediate smoldering myeloma, treatment with single-agent lenalidomide significantly delayed progression to full-blown disease.
Medscape Medical News

Music Cuts Need for Antipsychotics in Agitated Inpatients

Mon, 20 May 2019 10:18:29 +0000

Opting for music as a calming technique reduces the need for antipsychotics and length of stay in psychiatric inpatients with agitation, new research shows.
Medscape Medical News

Регулярное употребление фруктовых соков может сократить жизнь

Mon, 20 May 2019 16:54:13 +0000

Большинство людей знают о вреде сладких газированных напитков, однако новое исследование показывает, что и фруктовые соки не намного лучше.

Compassion Fatigue and the Hardship of Caring

Mon, 20 May 2019 08:59:09 +0000

Care teams deal with the pain, trauma, and death of patients, but most nurses are not taught how to handle their own feelings. Compassion fatigue can affect anyone and must be addressed, experts say.
Medscape Medical News

Research Needed to Unravel Pieces of Thyroid-CVD Jigsaw

Mon, 20 May 2019 07:15:48 +0000

An international working group recommends a research agenda focusing on subgroups and the effects of thyroid medications on cardiovascular health.
Medscape Medical News

Рейтинг, регалии, стоимость приема: как найти врача, которому можно доверять?

Mon, 20 May 2019 09:59:09 +0000

Каждый из нас хотя бы раз задавался этим вопросом. Стоит ли доверять интернету или лучше прислушаться к совету друзей, а может отдаться на волю судьбы и обратиться в поликлинику по месту «прикрепления», ведь настоящий профессионал остается таким везде. От правильного ответа на этот вопрос зависит, как минимум, количество потраченных денег, но что гораздо важнее – наше здоровье.

Избыточное употребление витаминов В6 и В12 увеличивает риск перелома бедра

Mon, 20 May 2019 08:44:34 +0000

Согласно новому американскому исследованию, у пожилых женщин, которые принимают биологически активные добавки с высокими дозами витаминов B6 и B12, выше риск перелома бедра.

More Than Morning Sickness: Treating Hyperemesis Gravidarum

Sun, 19 May 2019 10:38:47 +0000

This complication of pregnancy — in the news because both Kate Middleton, Duchess of Cambridge, and comedian Amy Schumer were affected — often goes undiagnosed, but long-term effects can be serious.
Medscape Medical News

FDA Okays Venclexta Plus Gazyva for Previously Untreated Chronic Lymphocytic Leukaemia

Fri, 17 May 2019 16:19:51 +0000

Roche said on Thursday that the U.S. Food and Drug Administration had approved Venclexta (venetoclax) in combination with Gazyva (obinutuzumab) for the treatment of people with previously untreated chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL).
Reuters Health Information

U.S. Anti-Abortion Groups Plot Course From State Capitals to Supreme Court

Fri, 17 May 2019 17:33:52 +0000

Anti-abortion advocacy groups have pushed hard in recent months for the passage of bills to restrict or even ban the procedure outright at the state level, inspired by the perception that the U.S. Supreme Court has tilted in their favor.
Reuters Health Information

North Carolina Attorney General Sues Juul for Targeting Youth

Fri, 17 May 2019 17:38:29 +0000

North Carolina's Attorney General filed a lawsuit against Juul Labs Inc on Wednesday, piling more pressure on the biggest U.S. e-cigarette maker that is already under intense scrutiny for its products' usage among teenagers.
Reuters Health Information

Missouri Senate Passes Bill to Ban Abortions After Eight Weeks

Fri, 17 May 2019 17:49:52 +0000

Missouri's Republican-controlled Senate passed a bill early on Thursday that would ban abortions after the eighth week of pregnancy except in medical emergencies.
Reuters Health Information

Rectal Exam Needed to Determine Cause of Constipation

Sat, 18 May 2019 23:58:10 +0000

Digital rectal examinations can save time and money in diagnosing and treating constipation, but they are too often avoided.
Medscape Medical News

Daily Aspirin May Lower Risk for Fatty Liver Progression

Fri, 17 May 2019 20:37:07 +0000

Daily aspirin may reduce the risk for progression to fibrosis and NASH in fatty liver disease, observational data suggest; more research is needed before recommending daily aspirin in NAFLD.
Medscape Medical News

CMS Reverses Course: 'Protected' Drug Classes Still Covered

Fri, 17 May 2019 19:19:18 +0000

But the agency is reaffirming that step therapy is allowed for Part B drugs under Medicare Advantage.
Medscape Medical News

FDA Warns Against Use of Unauthorized Diabetes Devices

Fri, 17 May 2019 19:40:01 +0000

The warning, based on a single case report, prompted responses from the developers of do-it-yourself artificial pancreas systems and JDRF.
Medscape Medical News

Arrest Made in NYC Hospital Sex Assault on Comatose Woman

Fri, 17 May 2019 17:57:03 +0000

The woman's roommate at Lincoln Medical Center in the Bronx saw the attack and called a nurse, who scared the man off. The suspect turned himself in after surveillance camera footage was broadcast.
Medscape Medical News

EMA Puts Temporary Restrictions on Tofacitinib Due to PE Risk

Fri, 17 May 2019 17:06:34 +0000

The EMA's safety committee advises physicians not to prescribe the 10-mg twice-daily dose of tofacitinib to patients who are at high risk for pulmonary embolism, pending results of an ongoing safety review.
News Alerts

Large Quantities of Grapefruit Juice Prolong QT Interval

Fri, 17 May 2019 17:11:03 +0000

Numerous drugs prolong the QT interval, but a new study suggests overconsumption of grapefruit juice can have the same effect, raising the possibility of "proarrhythmic food," researchers say.
Medscape Medical News

EU Panel Backs Market Withdrawal of Fenspiride Due to Heart Risk

Fri, 17 May 2019 17:47:56 +0000

The European Medicines Agency's Pharmacovigilance Risk Assessment Committee recommended revoking marketing authorizations for fenspiride medicines, preventing them from being marketed in the EU.
News Alerts

Advanced Stage at Cancer Diagnosis, Higher Mortality in US Patients With HIV

Fri, 17 May 2019 16:24:32 +0000

Cancer patients with HIV in the U.S. are more likely to be diagnosed at advanced disease stages and experience higher cancer-related mortality than cancer patients without HIV, researchers say.
Reuters Health Information

Pentazocine Cuts Acute Pancreatitis Pain Better Than Diclofenac

Fri, 17 May 2019 16:11:06 +0000

In acute pancreatitis, the opioid pentazocine relieves pain better than the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, a randomized controlled trial from India shows.
Reuters Health Information

'Be Nice' and Document to Prevent Malpractice Suits

Fri, 17 May 2019 13:21:14 +0000

The case of a medical team in Georgia that lost a lawsuit has takeaways for others about how to keep patients safe and protect those who care for them when things go wrong.
Medscape Medical News

Baroreflex Activation in No-CRT HF Scores Again, FDA Watching

Fri, 17 May 2019 15:21:00 +0000

For heart failure patients unsuitable for pacing therapy who've maxed out on meds, 'this I think is the first compelling evidence of a positive electromechanical intervention that makes a difference.'
Medscape Medical News

FDA OKs Teduglutide for Children With Short Bowel Syndrome

Fri, 17 May 2019 15:46:02 +0000

Teduglutide is the only glucagon-like peptide-2 analog approved that improves intestinal absorption in patients with short bowel syndrome who are dependent on parenteral support.
FDA Approvals

'Be Nice' and Document to Prevent Malpractice Suits

Fri, 17 May 2019 13:21:14 +0000

A medical team in the state of Georgia lost a recent lawsuit and their case has takeaways for others about how to keep patients safe and protect those who care for them when things go wrong.
Medscape Medical News

High Vitamin B6, B12 May Increase Hip Fracture Risk

Fri, 17 May 2019 14:22:51 +0000

A combined high intake of vitamins B6 and B12 was linked to an increased hip fracture risk, a study found.
Medscape Medical News

Machine-Learning Classifier Cuts Unnecessary CT in Kids After Head Trauma

Fri, 17 May 2019 13:05:09 +0000

A machine-learning model correctly identifies more children with head trauma who could avoid CT imaging than does the Pediatric Emergency Care Applied Research Network (PECARN) head-trauma decision rules, according to a database study.
Reuters Health Information

Smog-Ridden Mexico City Suspends School Classes Due to Pollution

Fri, 17 May 2019 11:56:29 +0000

Mexico's government ordered schools in and around Mexico City to be closed on Thursday in an extraordinary step taken due to elevated levels of pollution in the smog-wreathed capital.
Reuters Health Information

Scientists in New Push to Control Cancer Before Curing It

Fri, 17 May 2019 12:06:06 +0000

Cancer scientists in Britain are launching what they call the world's first "Darwinian" drug development program in a bid to get ahead of cancer's ability to become resistant to even the newest treatments and recur in many patients.
Reuters Health Information

Spotted Fever Rickettsiosis Shows Sharp Uptick in the US

Fri, 17 May 2019 12:50:31 +0000

In recent years there have been "unprecedented increases" in reports of nationally notifiable tickborne diseases, according to researchers at the Centers for Disease Control and Prevention (CDC) in Atlanta.
Reuters Health Information

Bullied Kids More Likely to Use Painkillers

Fri, 17 May 2019 12:40:46 +0000

Children and teens who are bullied are more than twice as likely as peers who are not victimized to take painkillers, a study of school kids in Iceland suggests.
Reuters Health Information

Charcoal Toothpaste May Do Harm and Not Much Good

Fri, 17 May 2019 12:29:17 +0000

Charcoal toothpaste may be having a moment as a go-to brightening and whitening tool, but some dentists say these products might actually damage tooth enamel and make cavities more likely.
Reuters Health Information

High Juice Consumption May Up Mortality Risk

Fri, 17 May 2019 12:15:35 +0000

Despite fruit juice's reputation as a healthier alternative to soda, the sugar in fruit juice may be just as dangerous, study shows.
Medscape Medical News

Cardiac Strain Imaging Predicts Mortality in SAH

Fri, 17 May 2019 10:58:51 +0000

Measuring wall strain of the heart appears to be a good prognostic indicator of brain injury in patients with subarachnoid hemorrhage, a new study shows.
Medscape Medical News

'Unprecedented' Rise in Suicide Rates Among Young Girls

Fri, 17 May 2019 11:00:45 +0000

Suicide rates among young girls have tripled over a 15-year period, results of a new study from the CDC show.
Medscape Medical News

Only 1 in 5 With High-Risk AF Leave ED on Anticoagulant

Fri, 17 May 2019 09:51:55 +0000

A study of nearly 450 people with atrial fibrillation (AF) treated in the emergency department suggests that anticoagulants may be 'vastly underutilized' for the prevention of stroke.
Medscape Medical News

Hundreds at Leading New York Hospital Call for 'Culture Shift'

Fri, 17 May 2019 09:58:31 +0000

More than 500 faculty, staff, and students at the Icahn School of Medicine at Mount Sinai signed letters protesting discrimination alleged in a lawsuit against the institution.
Medscape Medical News

HRS Consensus on Catheter Ablation of Ventricular Arrhythmias

Fri, 17 May 2019 10:10:58 +0000

The global effort fully updates 2009 recommendations and reflects the rapid progress seen in the field.
Medscape Medical News

Почему мы толстеем от переработанной пищи

Fri, 17 May 2019 16:02:15 +0000

Люди, рацион которых состоит из ультра-переработанных продуктов, ежедневно потребляют на 500 калорий больше, чем когда они же едят минимально обработанную пищу, согласно результатам исследования, проведенного Национальными институтами здравоохранения США и опубликованного в Cell Metabolism.

«Важно, чтобы поправки не отбросили нас назад»

Fri, 17 May 2019 15:39:02 +0000

Госдума приняла во втором чтении поправки в закон №323-ФЗ «Об основах охраны здоровья граждан в РФ», касающиеся доступа в реанимацию или отделение интенсивной терапии родственников пациентов. Документ разочаровал экспертов: по мнению Фонда помощи хосписов «Вера», сам по себе этот закон вряд ли изменит сегодняшнюю ситуацию.

Guidelines Nix Annual TB Testing for Most Healthcare Workers

Fri, 17 May 2019 07:52:02 +0000

Healthcare workers should be tested for tuberculosis when they are hired and should be retested only after an occupational exposure, according to new CDC guidelines.
Medscape Medical News

Фрукты и ограничение жирности рациона снижают риск смерти от рака молочной железы

Fri, 17 May 2019 08:38:34 +0000

Низкожировая диета, подобная той, которая рекомендуется для поддержания здоровья сердца, также связана со снижением риска смерти от рака молочной железы, согласно новому масштабному исследованию.

Nonprofit Generic Drug Venture to Start With Two Antibiotics

Thu, 16 May 2019 21:04:10 +0000

Civica Rx, a nonprofit generic drug company formed by health systems, announced the first drugs it will produce are the intravenous antibiotics vancomycin and daptomycin.
Medscape Medical News

[Review] Refractive surgery

Thu, 16 May 2019 23:00:10 +0000

Refractive surgery has evolved beyond laser refractive techniques over the past decade. Laser refractive surgery procedures (such as laser in-situ keratomileusis), surface ablation techniques (such as laser epithelial keratomileusis), and photorefractive keratectomy have now been established as fairly safe procedures that produce excellent visual outcomes for patients with low-to-moderate amounts of ametropia. Additionally, a broader selection of options are now available to treat a wider range of refractive errors.

[Review] Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events

Thu, 16 May 2019 23:00:09 +0000

Mass gathering events are associated with major public health challenges. The 2014 Lancet Series on the new discipline of mass gatherings medicine was launched at the World Health Assembly of Ministers of Health in Geneva in May, 2014. The Series covered the planning and surveillance systems used to monitor public health risks, public health threats, and experiences of health-care providers from mass gathering events in 2012 and 2013. This follow-up Review focuses on the main public health issues arising from planned mass gathering events held between 2013 and 2018.

[Clinical Picture] A pain in the neck: calcific tendinitis of the longus colli muscle

Thu, 16 May 2019 23:00:09 +0000

A 41-year-old man presented to our hospital with a 20-h history of progressively worsening sudden-onset, severe, left-sided neck pain. Additionally, he complained of a headache in the occipital region, odynophagia, and trismus. He reported no medical history of trauma or infection. A physical examination showed he had severely limited neck motion in all directions because of stiffness. Blood tests showed a leucocytosis (13·0 × 109 per L), an elevated serum C-reactive protein concentration (124 mg/L), and a faster erythrocyte sedimentation rate (24 mm/h).

[Articles] Clinical outcomes after ABO-incompatible renal transplantation: a systematic review and meta-analysis

Thu, 16 May 2019 23:00:09 +0000

Despite progress in desensitisation protocols and optimisation of ABOi-rTx procedures, excess mortality and loss of kidney grafts was found compared with ABOc-rTx within the first 3 years after transplantation. Only long-term outcomes after 5 years yielded equivalent survival rates and organ function. Awareness of the increased risks of infection, organ rejection, and bleeding could improve care of patients and promote efforts towards paired kidney exchange programmes.

[Articles] Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial

Thu, 16 May 2019 23:00:09 +0000

SABR was associated with an improvement in overall survival, meeting the primary endpoint of this trial, but three (4·5%) of 66 patients in the SABR group had treatment-related death. Phase 3 trials are needed to conclusively show an overall survival benefit, and to determine the maximum number of metastatic lesions wherein SABR provides a benefit.

[Articles] Effects, equity, and cost of school-based and community-wide treatment strategies for soil-transmitted helminths in Kenya: a cluster-randomised controlled trial

Thu, 16 May 2019 23:00:09 +0000

Community-wide treatment was more effective in reducing hookworm prevalence and intensity than school-based treatment, with little additional benefit of treating every 6 months, and was shown to be remarkably equitable in coverage and effects.

[Department of Error] Department of Error

Thu, 16 May 2019 23:00:09 +0000

The Lancet. Measles eradication: a goal within reach, slipping away. Lancet 2019; 393: 1669—In this Editorial, it was reported that the combined measles, mumps and rubella vaccine (MMR) was introduced in 1963, when this vaccine was first introduced in 1971. Corrections to that effect have been made to the online version as of May 16, 2019.

[Department of Error] Department of Error

Thu, 16 May 2019 23:00:09 +0000

Dransfield M, Stolz D, Kleinert S for the Lancet COPD Commissioners. Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission. Lancet 2019; 393: 1786–88—In this Comment, in the list of Commissioners' names the spelling of Urs Frey has been corrected. This correction has been made to the online version as of May 16, 2019.

[Department of Error] Department of Error

Thu, 16 May 2019 23:00:09 +0000

Malvy D, McElroy AK, de Clerck H, Günther S, van Griensven J. Ebola virus disease. Lancet 2019; 393: 936–48—In this Seminar, the appendix was incomplete; an updated version has been supplied. These corrections have been made to the online version as of May 16, 2019.

[Correspondence] Reporting sex and gender in medical research

Thu, 16 May 2019 23:00:09 +0000

We read the theme issue on advancing women in science, medicine, and global health with great enthusiasm, and here we write in response to the Comment by Jocalyn Clark and Richard Horton.1 Although they set clear parameters for improving equity in the academic publishing system across all Lancet journals, it is but a first step. A systematic and mandatory approach to reporting sex and gender, which covers all papers considered for publication, is necessary, unless justified otherwise.

[Correspondence] Gender equity on journal editorial boards

Thu, 16 May 2019 23:00:09 +0000

I read with interest what Editors at The Lancet are doing about gender and diversity.1 Gender inequities are at odds with the ethics to which we as a health-care community ascribe. For example, professionalism is one of the six core competencies mandated by the Accreditation Council for Graduate Medical Education in the USA, and the American College of Physicians has specifically stated in its ethics manual that discrimination violates the principles of professionalism.2 Therefore, allowing workforce gender discrimination that could be addressed to persist is unethical.

[Correspondence] Co-first authorship and gender equity in academic publishing

Thu, 16 May 2019 23:00:09 +0000

In response to the Comment by Jocalyn Clark and Richard Horton.1 about action on gender and diversity at The Lancet, as young female researchers, we would like to share our recent experience of publishing in your journal and to highlight the value of co-first authorship in promoting female academics.

[Correspondence] Rheumatoid arthritis-associated bronchiectasis – Authors' reply

Thu, 16 May 2019 23:00:09 +0000

We appreciate the interest in our review of bronchiectasis.1 We thank Xavier Puéchal and colleagues for reminding us of the association between CFTR gene variants and outcomes in patients with rheumatoid arthritis and bronchiectasis.2,3 This idea supports our suggestion that therapeutic interventions might not only target the underlying causes, but the predisposing factors that can modify progression of disease. Perhaps drugs that modulate CFTR protein function could eventually be used in the treatment of such patients.

[Correspondence] Rheumatoid arthritis-associated bronchiectasis

Thu, 16 May 2019 23:00:09 +0000

We read with great interest the comprehensive review of diffuse bronchiectasis by Patrick Flume and colleagues (Sept 8, 2018, p880).1 The authors mentioned the autoimmune diseases (most notably, rheumatoid arthritis and ulcerative colitis) that can be associated with bronchiectasis and for which causative genes have not yet been identified. We agree with their conclusion; however, as they exclusively detailed the associated genetic risk loci in inflammatory bowel diseases, we would like to add that, to our knowledge, the only family-based association study in patients with non-cystic fibrosis diffuse bronchiectasis was done in patients with rheumatoid arthritis.

[Correspondence] Post-surgery mortality in Poland – Author's reply

Thu, 16 May 2019 23:00:09 +0000

Stanislaw Krawczyk refers to the director Patryk Vega and his film Botoks, which provides a fictional account of the experiences of individuals receiving health care in Poland. The film, which has been widely viewed, caused outrage among health-care workers in Poland, who are depicted in an extremely negative way, perhaps the most striking example being the serious sexual assault of a patient by a member of hospital staff. The film is provocative to say the least, and some consider it deliberately misleading.

[Correspondence] Post-surgery mortality in Poland

Thu, 16 May 2019 23:00:09 +0000

In 2012, The Lancet published the results of a 7 day cohort study on mortality after surgery in Europe (Sept 22, 2012, p 1059).1 The Article contained information that was inappropriately used in Poland to promote a film, Botoks, which was watched by more than 2 million people. I am concerned that these data could still be used in similar ways.

[Correspondence] The measles crisis in Europe—the need for a joined-up approach

Thu, 16 May 2019 23:00:09 +0000

Measles elimination in Europe is in crisis. More than 80 000 confirmed cases were reported in 2018 in the 53 countries in the WHO European Region,1 the highest figure for 20 years. 14 countries in the region reported more than 500 confirmed cases, including four countries that were previously deemed to have eliminated measles (Greece, Albania, Israel, and the UK), meaning interrupted transmission for 3 years. New strategies are urgently needed to put measles elimination in Europe back on track.

[Obituary] Sydney Brenner

Thu, 16 May 2019 23:00:09 +0000

Key player in the development of molecular biology and genetics. He was born in Germiston, South Africa, on Jan 13, 1927, and died in Singapore on April 5, 2019, aged 92 years.

[Perspectives] Adolescence and mental health

Thu, 16 May 2019 23:00:09 +0000

Adolescence is a time of change: changes to hormones and the body, changes in the social environment, and changes to the brain and the mind. Although most young people develop into healthy adults, adolescence confers vulnerability to mental health problems. Many mental illnesses, including depression, anxiety, eating disorders, substance use disorders, and psychosis, first appear before the age of 24 years. What is it about adolescence that increases vulnerability to mental health problems? This is a crucial question because some mental illnesses that start in adolescence persist throughout adult life, creating long-term morbidity and a substantial burden on society.

[Perspectives] Kameron Matthews: reaching underserved patient populations

Thu, 16 May 2019 23:00:08 +0000

Family physician Kameron Matthews remembers meeting a college freshman with a passion for science and a near-perfect grade-point average to prove it. They met a few years ago during one of the campus bus tours Matthews organised to inspire students of colour to enter the health professions. The student's college adviser had discouraged her from becoming a doctor. “She didn't understand why”, said Matthews, who is Deputy Undersecretary for the Department of Veterans Affairs' (VA) Office of Community Care in Washington, DC, USA.

[Perspectives] Of journeys less known: outlawed love and sex in India

Thu, 16 May 2019 23:00:08 +0000

When I was seeking out queer culture as a young gay person in pre-internet times, the only written accounts of queer lives I found were of gay white men from western countries, such as Edmund White, Paul Monette, Quentin Crisp, and Andrew Tobias. All superb and vital reading, yet somewhat alien to my Indian context. I'd have appreciated reading Siddharth Dube's An Indefinite Sentence: A Personal History of Outlawed Love and Sex back then. Dube's rich memoir traces many issues, including his coming of age as a gay man who wrestled with and discovered his sexuality in an urban, westernised, upper-middle-class Indian context, suppressing his effeminacy in the face of phobic acquaintances, the excruciating viciousness of dorm life in an all-male boarding school, and the experience of loneliness and helplessness as a young gay person, despite his privileged background.

[World Report] Low-cost pneumonia vaccine breaks into global market

Thu, 16 May 2019 23:00:08 +0000

Pneumococcal vaccination could become less costly for Gavi, The Vaccine Alliance, as a new, cheaper, alternative hits the market. Ann Danaiya Usher reports.

[World Report] Turkish doctors sentenced to jail for statement on war

Thu, 16 May 2019 23:00:08 +0000

Doctors who called war a “man-made public health problem” receive jail sentences, in the latest government-led assault on the Turkish Medical Association. Sharmila Devi reports.

[World Report] Denver votes to decriminalise psilocybin mushrooms

Thu, 16 May 2019 23:00:08 +0000

A provisional result from a local ballot means so-called magic mushrooms use could be decriminalised in Denver, raising questions for research and commercial use. Paul Webster reports.

[Comment] Offline: The fight for Europe

Thu, 16 May 2019 23:00:08 +0000

What does Europe stand for? This question hangs ominously over forthcoming elections to the European Parliament, which will take place on May 23–26, 2019. Europe confronts monumental challenges: economic stagnation, inequality, unemployment, a climate emergency, and erosion of democratic values. Elites are mistrusted, even hated, by millions of voters who feel ignored and reviled by Brussels. Europe has lost its way. As Time Magazine recently put it, Europe is “unravelling”. The influential German sociologist, Wolfgang Streeck, has called Europe a “doomed empire”.

[Comment] A call for clinicians to act on planetary health

Thu, 16 May 2019 23:00:08 +0000

We are rapidly changing the world around us. A growing and urbanising human population with expanding patterns of production and consumption is driving rapid global environmental change, manifested in large-scale biodiversity loss, climate change, deforestation and land degradation, resource scarcity, changing biogeochemical flows, and pollution.1 While the second half of the 20th century has seen major global health gains, the future of global health is increasingly under threat, with a growing non-communicable disease burden, expanding nutritional vulnerability, new infectious disease exposures, and susceptibility to displacement, injury, and mental health risks, all of which disproportionately threaten the poor, the young, the elderly, and future generations.

[Comment] The Lancet Commission on diagnostics: advancing equitable access to diagnostics

Thu, 16 May 2019 23:00:08 +0000

For too long, the crucial role of diagnostics as a foundation of effective and high-quality health care has been neglected. Due to poor access, people in low-income and middle-income countries (LMICs) and those among low-income groups in high-income countries have frequently received treatment that is initiated without the support of essential diagnostic tests. All too often, such presumptive treatment leads to poor health outcomes, wastes scarce resources on wrong treatments, fails to develop accurate epidemiological data, and contributes to development of antimicrobial resistance.

[Comment] WHO takes action to promote the health of refugees and migrants

Thu, 16 May 2019 23:00:08 +0000

Migration is a defining issue of our time.1 There are 1 billion migrants globally, of whom 258 million have crossed borders.2 Climate change and political instability propel ever-greater displacement, with major detriments to health.3 Policies that fail to prevent human trafficking or guarantee essential services to migrants undermine universal health coverage (UHC) and the global pledge in the UN 2030 Agenda for Sustainable Development to “leave no one behind”. The World Health Assembly (WHA) on May 20–28, 2019, should adopt, and robustly implement, WHO's Global Action Plan on Promoting the Health of Refugees and Migrants, 2019–2013 (GAP).

[Comment] ABO-incompatible renal transplantation

Thu, 16 May 2019 23:00:08 +0000

The shortfall between organ donors and a growing population with end-stage kidney disease has resulted in increased transplant waiting times for patients, with increased mortality as a consequence.1 Strategies to reduce this deficit include expanding the live donor pool by crossing the blood group barrier with ABO-incompatible live donor pairs. ABO-incompatible renal transplantation (ABOi-rTx) has been in practice worldwide for over three decades. Initially regarded as having similar outcomes to ABO-compatible renal transplantation (ABOc-rTx),2 more recent registry reports have suggested otherwise.

[Comment] Community-wide soil-transmitted helminth treatment is equity-effective

Thu, 16 May 2019 23:00:08 +0000

Among the 20 diseases included on the WHO list of neglected tropical diseases, the soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are the most prevalent (>1 billion people infected) and the most burdensome (global burden of 3 million disability-adjusted life years).1,2 At the turn of the new millennium, preventive chemotherapy—the periodic administration of donated anthelmintic drugs to pre-school-age and school-age children—had been embraced as the global strategy for morbidity control of soil-transmitted helminths.

[Editorial] Smoke and mirrors: new tobacco products and Formula 1

Thu, 16 May 2019 23:00:08 +0000

Clear links between Formula 1 and smoking were rightly confined to history decades ago. However, it now appears that connections are developing once more. British American Tobacco (BAT) joined with McLaren in February to advertise several products including a so-called heat-not-burn, tobacco-containing device—a hybrid of the e-cigarette and the traditional cigarette. Under the branding “A Better Tomorrow”, the union is about “transforming [the] tobacco agenda, at the heart of our portfolio of potentially reduced risk products”, BAT told The Lancet on May 8.

[Editorial] Centring the invisible mother

Thu, 16 May 2019 23:00:08 +0000

The USA had an average pregnancy-related mortality (PRM) of 17·2 per 100 000 livebirths between 2011–15, according to a report from the US Centers for Disease Control and Prevention (CDC). Released May 7, the report found that approximately 700 women in the USA die each year because of pregnancy-related conditions, and 60% of maternal deaths were preventable if “one or more reasonable changes” had occurred. Causes of death varied by time prepartum and postpartum, but the most common were cardiovascular conditions.

[Editorial] Reducing the risk of dementia

Thu, 16 May 2019 23:00:08 +0000

Dementia is one of the fastest growing public health problems. According to data from the 2016 Global Burden of Disease Study, the number of people living with dementia worldwide more than doubled from 20·2 million in 1990, to 43·8 million in 2016. This number is expected to double again by 2030, with the steepest rises in low-income and middle-income countries where the effects of rapid population ageing are driving the increase in dementia. The 2015 World Alzheimer Report estimated that the annual global cost of dementia was more than US$800 billion, more than 85% of which relates to family and social costs rather than medical care.

Lead Measured in Teeth of Kids Living Near Former Battery-Recycling Plant

Thu, 16 May 2019 15:54:36 +0000

Children living near a former car-battery recycling plant in Los Angeles have lead in their baby teeth at levels that track with neighborhood contamination, according to a study of exposure to the toxic metals in the womb and during early childhood.
Reuters Health Information

Pradaxa Fails to Prevent Recurrence After Cryptogenic Stroke

Thu, 16 May 2019 16:13:55 +0000

Dabigatran, sold under the brand name Pradaxa by Boehringer Ingelheim to prevent stroke in people with atrial fibrillation, is no more effective than aspirin for preventing a subsequent stroke in patients who have experienced a cryptogenic stroke.
Reuters Health Information

New App Boosts Kids' Asthma Management

Thu, 16 May 2019 16:00:49 +0000

After 1 year of use, e-AT helped prevent severe attacks, reduced school absences and lost work time, cut hospital admissions, and improved quality of life.
Medscape Medical News

Light Physical Activity Might Help Keep the Brain Young

Thu, 16 May 2019 15:28:24 +0000

A recent study suggests that light physical activity may help stave off signs of aging in the brain.
Reuters Health Information

FDA OKs Dalteparin (Fragmin), First Anticoagulant for Pediatric VTE

Thu, 16 May 2019 15:00:59 +0000

The low-molecular-weight heparin is indicated to reduce the recurrence of symptomatic venous thromboembolism in children as young as 1 month.
FDA Approvals

Mild Hypothyroidism Being Overtreated, Avoid Pills, Says Panel

Thu, 16 May 2019 15:34:42 +0000

In a "strong recommendation," an international panel of experts advise that patients with subclinical hypothyroidism should not be routinely prescribed levothyroxine; evidence shows few benefits.
Medscape Medical News

YOUR MONEY-Depression Risk Could Derail Your Retirement Portfolio

Thu, 16 May 2019 13:53:57 +0000

Retirement savings can suffer from interest rate moves, market volatility and other financial risks, but depression can be just as damaging.
Reuters Health Information

'Striking' Responses in Pediatric Solid Tumors With Entrectinib

Thu, 16 May 2019 14:11:40 +0000

A novel targeted therapy produced impressive responses among children and adolescents with rare tumors that had progressed or were refractory to previous therapy.
Medscape Medical News

Hypoalbuminemia Linked to Worse Outcomes After IBD Surgery

Thu, 16 May 2019 12:55:24 +0000

Hypoalbuminemia is associated with worse mortality and complication rates after major abdominal surgery related to inflammatory bowel disease (IBD), according to a database study.
Reuters Health Information

Performance Reporting Could Cut Overuse of Mohs Micrographic Surgery

Thu, 16 May 2019 13:45:04 +0000

Individualized performance reports delivered to surgeons appear to reduce extreme overuse of Mohs micrographic surgery (MMS), according to results from a nonrandomized intervention study.
Reuters Health Information

Venezuela Dialysis Patients Face Uncertain Fate After Power Cuts

Thu, 16 May 2019 11:54:22 +0000

Seconds before William Lopez was set to be connected to a dialysis machine at a state-run clinic in the western Venezuelan city of Maracaibo in April, the power went out.
Reuters Health Information

Neuropathy May Drive Dry Eye in Migraine Patients

Thu, 16 May 2019 12:14:58 +0000

Migraine patients with dry eye (DE) are more likely to have symptoms suggestive of neuropathy than DE patients who don't have migraines, according to new findings.
Reuters Health Information

E-Cigarettes and Tobacco Cigarettes Induce Similar Acute Respiratory Response

Thu, 16 May 2019 12:40:08 +0000

Short-term respiratory responses to use of e-cigarettes and tobacco cigarettes are similar, researchers say.
Reuters Health Information

Ticagrelor: A New Antibiotic?

Thu, 16 May 2019 12:43:30 +0000

The antiplatelet agent has bactericidal activity against multidrug-resistant gram-positive bacteria and may represent a new class of antibiotic, new research suggests.
Medscape Medical News

Vagal Stimulation Lessens Paroxysmal AF in Sham-Controlled Study

Thu, 16 May 2019 12:47:57 +0000

AF burden fell significantly over 6 months for patients receiving electrical vagus nerve stimulation in daily 1-hour sessions in a small randomized study that invites confirmation in larger trials.
Medscape Medical News

Цифровая медицина: готово ли российское здравоохранение использовать новые технологии

Thu, 16 May 2019 18:09:41 +0000

Журнал Европейского бюро ВОЗ Public Health Panorama опубликовал исследование, посвященное готовности российской медицины к внедрению цифровых технологий. Авторы работы – ученые Сеченовского университета и сотрудники НИИ организации и информатизации здравоохранения – описали современное состояние отрасли и предложили шаги, которые помогут эффективно применять новые технологии.

Nearly 1 in 10 With MI at Young Age Have Familial Hypercholesterolemia

Thu, 16 May 2019 11:37:32 +0000

Familial hypercholesterolemia (FH) is present in 9% of people who experience a myocardial infarction (MI) at age 50 or younger, most of whom continue to have elevated cholesterol at one-year follow-up, according to new research.
Reuters Health Information

'Dense Breast' Proposal Would Lead to Unnecessary Worry and Tests

Thu, 16 May 2019 11:05:03 +0000

The FDA's recent proposal that all women and their referring physicians should receive a breast density report after each mammogram will lead to unnecessary tests and worry, warn experts.
Medscape Medical News

Very Obese Teens: Promote or Postpone Gastric Bypass?

Thu, 16 May 2019 11:45:43 +0000

The decision on whether to recommend bariatric surgery for adolescents with severe obesity or postpone it to adulthood needs to be made after careful consideration of harms vs benefits, says an expert.
Medscape Medical News

Удаление аппендицита связали с риском болезни Паркинсона

Thu, 16 May 2019 17:04:26 +0000

По данным нового крупномасштабного американского исследования, у людей, подвергшихся удалению аппендикса, в три раза выше риск заболеть болезнью Паркинсона.

Endocrine-Disrupting Chemicals Affect Reproductive Health

Wed, 15 May 2019 15:53:02 +0000

Obstetricians need to be aware of the effects of common chemicals on reproductive health so they can counsel patients and be advocates for more regulation to protect patients and their families.
Medscape Medical News

One in 5 Residents Doubt Career Choice Despite Ample Job Offers

Thu, 16 May 2019 08:25:30 +0000

Despite an abundance of job offers for new residents, the grind of residency, uncertainty about the future, big loans, and fellowships ahead for specialists all contribute to the pessimism of this segment.
Medscape Medical News

Возможно, желчный пузырь удаляют чаще, чем надо

Thu, 16 May 2019 14:19:06 +0000

Многим пациентам с желчными камнями и болью в животе часто не становится лучше после удаления желчного пузыря. Ученые попытались разобраться, всегда ли требуется операция в таких случаях. Статья опубликована в журнале Lancet.

More Than Half of Physicians Have Net Worth of at Least $1M

Thu, 16 May 2019 07:13:07 +0000

Seven percent have more than $5 million. Among specialties, gastroenterology had the most physicians in that group. Almost half owe at least $300,000 on their mortgages.
Medscape Medical News

Doctors Could Face Jail Time Under Alabama Abortion Law

Wed, 15 May 2019 12:20:21 +0000

The legislation, now the strictest abortion law in the nation, does not take effect for another 6 months.
Medscape Medical News

New WHO Dementia Guidelines Released

Wed, 15 May 2019 20:28:22 +0000

New guidelines issued by the World Health Organization recommend lifestyle change as the primary way to reduce the risk for cognitive decline and dementia.
Medscape Medical News

US Birth Rate Falls to Lowest Level in More Than 3 Decades

Wed, 15 May 2019 17:08:41 +0000

The US birth rate declined again last year for women in nearly all age groups, including teenagers, with the exception of women in their late 30s and early 40s.
Medscape Medical News

Substernal-Lead ICD May Be 'Inflection Point' in ICD Evolution

Wed, 15 May 2019 16:02:14 +0000

Some see the future in the device, functional as a standard implantable defibrillator but with a high-voltage lead that fits between the sternum and heart and no transvenous leads to ever extract.
Medscape Medical News

New AHA/ACC/AACVPR Statement on Home-based Cardiac Rehab

Wed, 15 May 2019 16:31:29 +0000

Home-based CR may be a reasonable option for clinically stable low- to moderate-risk patients who are eligible for CR but cannot attend a traditional center-based program.
Medscape Medical News

Профилактический прием антибиотиков после родов может снизить распространенность инфекций

Wed, 15 May 2019 19:11:10 +0000

Крупное британское исследование показало, что ежегодно тысячи женщин можно избавить от тяжелых, иногда угрожающих жизни, инфекций, если назначать им антибиотики в целях профилактики после родоразрешающих операций.

ВОЗ выпустила первые рекомендации по профилактике деменции: в них есть ЗОЖ и нет БАДов

Wed, 15 May 2019 19:14:11 +0000

В соответствии с первым руководством ВОЗ, снижение риска развития деменции связано с регулярной физической активностью, здоровым сбалансированным питанием, отказом от курения, уменьшением потребления алкоголя, а также поддержанием нормального артериального давления, уровня холестерина и уровня сахара в крови.

Doctors Could Face Jail Time Under Alabama Abortion Bill

Wed, 15 May 2019 12:20:21 +0000

The bill, which would be the strictest abortion law in the nation, is awaiting the governor's signature.
Medscape Medical News

FDA Okays Another Immunotherapy Plus TKI for Advanced RCC

Wed, 15 May 2019 12:32:52 +0000

The FDA has approved avelumab in combination with the tyrosine kinase inhibitor (TKI) axitinib for the first-line treatment of advanced renal cell carcinoma (RCC).
FDA Approvals

New Tool to Predict Childhood Asthma

Wed, 15 May 2019 12:49:09 +0000

A new screening approach helps pin down the likelihood that a child will develop asthma by the age of 7.
Medscape Medical News

Zilucoplan May Decrease Symptoms of Myasthenia Gravis

Wed, 15 May 2019 11:13:00 +0000

The novel self-administered subcutaneous agent is safe and relatively well tolerated in generalized myasthenia gravis, a new phase 2 trial and extension study report.
Medscape Medical News

Challenges and Successes Abound in Rural Healthcare

Wed, 15 May 2019 10:20:45 +0000

The National Rural Health Association's annual conference in Atlanta will highlight economic issues surrounding small town medical facilities; in Georgia, seven rural hospitals have closed since 2010.
Georgia Health News

Do Clinicians Need Additional Conscience Protections?

Wed, 15 May 2019 07:41:51 +0000

A new rule shoring up conscience protections for healthcare professionals raises concerns for patient care.
Medscape Reader Polls

Health Alliance Calls for Financial Incentives for Primary Care

Wed, 15 May 2019 06:10:11 +0000

A new health alliance is pushing for a lower-cost, higher-value system that addresses the needs of both consumers and a more robust primary care workforce.
Medscape Medical News

Пять важных вопросов о тестировании на ВИЧ

Wed, 15 May 2019 08:36:07 +0000

19 мая отмечается Всемирный день памяти жертв СПИДа. Заболевания, связанные с ВИЧ/СПИД, уже стали причиной смерти 35 миллионов человек в мире. Сегодня, по данным ЮЭЙДС, на планете насчитывается 36,9 миллиона людей, живущих с ВИЧ, и лишь 75% из них знают о своем положительном статусе. Не подозревает о своем заболевании и каждый четвертый ВИЧ-инфицированный россиянин.

Glucosamine Supplements Linked to Lower CVD Event Risks

Tue, 14 May 2019 18:31:30 +0000

The hypothesis-generating findings are biologically feasible and remained significant even after accounting for a slew of traditional risk factors.
Medscape Medical News

Most Parents Text While Driving, but Millennials May Be More Dangerous

Tue, 14 May 2019 16:24:11 +0000

More than half of U.S. parents believe it's unsafe to text while driving, but most of them do it anyway, a new survey suggests.
Reuters Health Information

Political Games Hinder Efforts to End Ebola Outbreak in Congo: WHO

Tue, 14 May 2019 16:12:37 +0000

Attempts to end the second worst Ebola outbreak on record are being hampered by "political games" and distrust of outsiders in two towns in Democratic Republic of Congo, a senior World Health Organization official said on Monday.
Reuters Health Information

Low LDL-C but High hsCRP Linked to Increased Events After PCI

Tue, 14 May 2019 16:24:56 +0000

In a registry study, PCI patients with residual inflammatory risk despite well-controlled LDL-C had more than double the risk for adverse events vs those with both low lipids and low hsCRP.
Medscape Medical News

FDA OKs Aflibercept (Eylea) for Diabetic Retinopathy

Tue, 14 May 2019 16:39:06 +0000

The VEGF inhibitor is already approved for neovascular (wet) age-related macular degeneration, macular edema after central retinal vein occlusion, and diabetic macular edema.
FDA Approvals

FDA Expands Impella Heart Pumps Use Duration

Tue, 14 May 2019 16:42:44 +0000

The indication allows the Impella 5.0 and Impella LD heart pumps to now be used for 14 days, up from just 6 days.
FDA Approvals

Antibiotics After Assisted Vaginal Delivery Reduce Infections

Tue, 14 May 2019 16:54:07 +0000

Prophylactic antibiotics administered at the time of assisted vaginal delivery can reduce the risk of maternal infection, a study found.
Medscape Medical News

FDA Seeks Input on Interchangeability of Biosimilar Insulins

Tue, 14 May 2019 15:11:16 +0000

Some argue that interchangeability testing requirements should be less stringent for insulin products than for other biosimilars.
Medscape Medical News

CRT Can Reverse HF From Cancer Chemotherapy: MADIT-CHIC

Tue, 14 May 2019 15:30:25 +0000

Added to heart failure meds, the pacing therapy can improve symptoms and reverse ventricular damage from chemotherapy in a group sometimes overlooked for proven treatments, says a prospective study.
Medscape Medical News

Patients With OIC Prefer Naloxegol, PEG 3350 Equally

Tue, 14 May 2019 15:34:26 +0000

Patients with opioid-induced constipation reported similar preference rates and strong preferences for treatment with either naloxegol or PEG 3350.
Medscape Medical News

Смерть близкого человека влияет на здоровье в течение четырех лет

Tue, 14 May 2019 18:40:36 +0000

Согласно новым исследованиям Австралийского национального университета, психологическая травма, вызванная смертью близкого человека, длится в четыре раза дольше, чем считалось ранее. Данные были опубликованы в журнале PLOS ONE. Исследователи предупреждают, что люди обычно недооценивают время, необходимое для того чтобы справиться с уходом умершего близкого человека, что приводи

При здоровом образе жизни организм хорошо справляется с редким перееданием

Tue, 14 May 2019 18:45:51 +0000

Если вы ведете здоровый образ жизни, периодически можно расслабиться и наслаждаться праздниками – организм приспосабливается и быстро приходит в норму, как показало новое австралийское исследование, опубликованное онлайн в Endocrinology and Metabolism.

Undiagnosed Sleep Apnea Ups Risk for Postop CV Events

Tue, 14 May 2019 11:01:23 +0000

Experts say obstructive sleep apnea should be seen as a perioperative risk factor for patients who undergo major noncardiac surgery.
Medscape Medical News

FDA: Sunscreen Chemicals in Blood Show Need for Safety Testing

Tue, 14 May 2019 11:33:25 +0000

Two coauthors from the FDA study discuss what the results mean.
WebMD Health News

Российские специалисты завили о необходимости своевременной вакцинации против ВПЧ

Tue, 14 May 2019 10:26:41 +0000

Вакцинация девочек-подростков против вируса папилломы человека (ВПЧ) в Шотландии кардинально изменила ситуацию с заболеваемостью раком шейки матки и развитием предрака. Если Россия не последует этому примеру, то через 10-20 лет «спасть возможно уже будет некого», считают ведущие российские специалисты.

Gilead to Donate Truvada to CDC to Help With HIV PrEP in US

Mon, 13 May 2019 18:07:59 +0000

While the Trump administration praised the donation, activists maintained their call for a reduction in the cost of the antiviral treatment, now pegged at more than $20,000 a year.
Medscape Medical News

Transgender Females Have Lower Tenofovir Diphosphate Concentrations

Mon, 13 May 2019 17:08:25 +0000

Transgender females taking feminizing hormone therapy (FHT) have lower effective rectal tissue concentrations of tenofovir diphosphate active metabolites, compared with cisgender women and men, researchers report.
Reuters Health Information

HSV Strains Recombining, Potentially Impacting Vaccine Development

Mon, 13 May 2019 17:15:06 +0000

Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are recombining, suggesting that live attenuated HSV-2 vaccine candidates carry a "significant risk" of recombining with circulating HSV-1 strains to form an infectious virus, researchers say.
Reuters Health Information

Younger Lacrosse Players Have More Concussions Than Older Players

Mon, 13 May 2019 17:31:12 +0000

Younger boys who play lacrosse are more likely to get injured and sustain concussions than high school or college players, a U.S. study suggests.
Reuters Health Information

Medicaid Work Rules Likely to Penalize Chronically Ill: Study

Mon, 13 May 2019 17:38:13 +0000

States that require adults on Medicaid to work a set number of hours to get benefits may find many people lose coverage because behavioral health conditions and other chronic health problems make it hard for them to work, a U.S. study suggests.
Reuters Health Information

How Much Does Healthcare Influence Longevity?

Mon, 13 May 2019 17:02:02 +0000

Healthcare plays a minor role in determining life span in the US; behavioral and social factors play a much bigger role, data suggest. The numbers indicate US health spending priorities are out of alignment.
Medscape Medical News

What's Hot: Your Guide to the APA 2019 Annual Meeting

Mon, 13 May 2019 17:27:42 +0000

This year's theme — Revitalize Psychiatry: Disrupt, Include, Engage and Innovate — is reflected throughout the program, which includes nearly 1000 posters, more than 650 sessions, and 170 speakers.
Medscape Medical News

Gaps Found in Diabetes Prevention Advice, Activities

Mon, 13 May 2019 17:31:48 +0000

Referral of high-risk adults to diabetes prevention programs was extremely low, even for those diagnosed with prediabetes.
Medscape Medical News

Dramatic Racial, Ethnic Disparities in Access to Buprenorphine

Mon, 13 May 2019 17:33:56 +0000

Opioid use disorder affects whites and people of color equally. However, new findings show large disparities in access to a leading evidence-based treatment.
Medscape Medical News

Following Opioid Suits, Family Behind Deadly OxyContin Squabbles

Mon, 13 May 2019 16:17:07 +0000

A united front among members of the billionaire Sackler family behind painkiller OxyContin is showing signs of strain from litigation over who bears responsibility for the deadly U.S. opioid epidemic.
Reuters Health Information

Pregnant Women With Refugee Status at Higher MDD Risk

Mon, 13 May 2019 16:43:03 +0000

Pregnant women who identify themselves as refugees have higher rates of major depressive disorder (MDD), Australian researchers report.
Reuters Health Information

Patients Equally Pleased With Different Keratoplasty Approaches

Mon, 13 May 2019 16:47:57 +0000

Although the Descemet Endothelial Thickness Comparison Trial (DETECT) showed better visual acuity with a newer, more demanding corneal transplantation method, this did not translate into greater patient satisfaction, according to a secondary analysis of outcome data.
Reuters Health Information

Experts Share Facts About Physician Suicide

Mon, 13 May 2019 16:50:14 +0000

Suicide is the only cause of death that is higher among doctors than the general population, according to two Canadian physicians who coauthored an information sheet about physician suicide.
Reuters Health Information

FDA Approves First Biomarker-Driven Drug for HCC

Mon, 13 May 2019 15:54:18 +0000

Ramucirumab is for the treatment of hepatocellular carcinoma in patients with an alpha-fetoprotein level of 400 ng/mL or higher.
FDA Approvals

Potential Biomarker for Suicidal Thoughts Identified in PTSD

Mon, 13 May 2019 16:12:39 +0000

Metabotropic glutamatergic receptor 5 availability is significantly higher in individuals with both PTSD and suicidal thoughts, new research suggests.
Medscape Medical News

Latest Data on Evobrutinib, New MS Therapy Targeting B Cells

Mon, 13 May 2019 16:19:17 +0000

Further data from the phase 2 trial of show a significant reduction in enhancing MRI lesions with one of the doses tested but increases in liver enzymes may be an issue.
Medscape Medical News

'Quantum Leap' in Severe Head Injury Survival With EMS Protocol

Mon, 13 May 2019 14:54:58 +0000

A real-world study shows a doubling of survival in patients with severe traumatic brain injury who receive prehospital guideline-based care by paramedics.
Medscape Medical News

Diabetes Tied to Cancer Risk in China, With Gender Differences

Mon, 13 May 2019 15:20:45 +0000

"We suggest that establishing strategies for regular cancer-specific screening and prevention care among patients with [type 2 diabetes] are necessary," the authors conclude.
Medscape Medical News

Who's High Risk for Device Infection? PADIT Risk Score Could Help

Mon, 13 May 2019 14:36:28 +0000

A 'clinician- and patient-friendly risk score' based on a trial comparing antibiotic strategies for ICD and pacemaker procedures could be a boon to decision-making, researchers and observers say.
Medscape Medical News

FDA OKs IncobotulinumtoxinA (Xeomin) First-Line in Blepharospasm

Mon, 13 May 2019 13:11:55 +0000

The FDA has approved broadening the indication for incobotulinumbtoxinA as first-line therapy for blepharospasm, based on a phase 3 trial presented at the recent American Academy of Neurology meeting.
FDA Approvals

Процедуры для увеличения полового члена оказались опасными и почти бесполезными

Mon, 13 May 2019 17:05:20 +0000

Как хирургические, так и консервативные процедуры по увеличению размера пениса достаточно рискованны и не являются эффективными. Эксперты считают, что их не следует проводить. Как показало новое исследование, они оставляют у многих мужчин не только физические, но и психологические шрамы. Кроме того, многие мужчины становятся жертвами шарлатанов.

Отцовство в зрелом возрасте несет угрозу как для будущего ребенка, так и для его матери

Mon, 13 May 2019 17:44:34 +0000

Откладывание мужчинами отцовства может негативно сказаться на здоровье их партнеров и детей, свидетельствуют результаты 40-летнего исследования о влиянии возраста родителей на фертильность, беременность и здоровье детей, опубликованные в журнале Maturitas.

Specialists Target Preventable Maternal Deaths

Mon, 13 May 2019 10:45:50 +0000

The maternal mortality rate in the United States is high, especially for black women, but different initiatives are helping lower the rate and address racial disparity.
Medscape Medical News

Hospitalists Highlight Lack of Respect in 45% Burnout Rate

Mon, 13 May 2019 10:47:17 +0000

The percentage of those saying they were disrespected by administrators or others was twice as high as that cited by nonhospitalists. Outside work, hospitalists were happier than nonhospitalists.
Medscape Medical News

Experimental Agent Offers First Hope for Rare Genetic Disorder

Mon, 13 May 2019 08:13:34 +0000

An experimental agent promises to improve the lives of patients with Angelman syndrome, a rare genetic disorder for which there are no approved therapies and that carries a high, unmet medical need.
Medscape Medical News

Increasing Alcohol Consumption Linked to Worsening HIV Severity

Sat, 11 May 2019 12:18:13 +0000

A pattern of increasing alcohol consumption is associated with worsening HIV disease severity, whereas stable consumption is associated with small improvements, according to a national study of VA patients with HIV.
Reuters Health Information

Opioid Overdose Deaths Decline When Pharmacists Can Dispense Naloxone

Sat, 11 May 2019 12:38:54 +0000

In states where pharmacists were allowed to sell the opioid antidote naloxone without a prescription, fewer people died from opioid overdoses, a new U.S. study finds.
Reuters Health Information

Many U.S. Allergists Now Prescribe Tablets Instead of Shots

Sat, 11 May 2019 12:52:11 +0000

Almost three in four U.S. allergy specialists are prescribing sublingual immunotherapy (SLIT) to ease symptoms caused by pollen, ragweed and dust at least some of the time, though they have not completely shifted away from allergy shots, a survey suggests.
Reuters Health Information

Trade Frictions Raise Questions About China's Fentanyl Promise

Sat, 11 May 2019 12:45:46 +0000

China has pledged to stem a flood of the synthetic opioid fentanyl onto America's streets, where it kills thousands of people a month, but U.S. security experts are skeptical about whether Beijing is willing, or even able, to follow through.
Reuters Health Information

Frustration Mounts as EpiPen Shortage Hits 1 Year

Sat, 11 May 2019 12:55:37 +0000

The shortage dates back to May 2018 and further shortages are expected.
WebMD Health News

Gallbladders May Be Removed Too Often

Fri, 10 May 2019 16:00:22 +0000

Many patients with gallstones and abdominal pain don't feel better after a procedure to remove their gallbladder, and a recent study suggests this surgery may not always be necessary.
Reuters Health Information

Trump Calls on Congress to Protect Patients From Surprise Medical Bills

Fri, 10 May 2019 16:00:34 +0000

U.S. President Donald Trump called on Congress on Thursday to pass legislation to protect patients from surprise medical bills from out-of-network doctors that can unnecessarily cost patients tens of thousands of dollars.
Reuters Health Information

Breath Analysis Shows Promise in Distinguishing IBD Types

Fri, 10 May 2019 16:07:57 +0000

A breath analyzer can identify inflammatory bowel disease (IBD) in affected individuals and distinguish ulcerative colitis (UC) from Crohn's disease (CD), a pilot study reveals.
Reuters Health Information

Low-Dose Anti-Thymocyte Globulin Preserves Beta-Cell Function in New-onset Type 1 Diabetes

Fri, 10 May 2019 16:15:25 +0000

Low-dose anti-thymocyte globulin (ATG) appears to preserve beta-cell function in patients with new-onset type 1 diabetes, researchers report.
Reuters Health Information

AF Ablation, Renal Denervation a Promising Team in ERADICATE-AF

Fri, 10 May 2019 16:11:04 +0000

Patients getting both procedures instead of AF ablation alone had less atrial fib over 1 year. Researchers are upbeat about the combination, others point to study limitations and other cautions.
Medscape Medical News

Botulinum Toxin Effective for BEB in Toxin-Naïve Patients

Fri, 10 May 2019 16:19:28 +0000

IncobotulinumtoxinA is indicated for patients with blepharospasm who previously received onabotulinumtoxinA — but a new phase 3 study suggests it's also effective as first-line therapy.
Medscape Medical News

UnitedHealthcare Aims to Cut Maternity Care Costs With New Program

Fri, 10 May 2019 15:20:18 +0000

UnitedHealthcare Group said on Thursday it had launched a new program to cut maternity costs under which partner hospitals would be paid a fixed rate for care during and after pregnancy, rather than for every service rendered.
Reuters Health Information

Bristol-Myers' Opdivo Fails Late-Stage Brain Cancer Trial

Fri, 10 May 2019 15:20:24 +0000

Bristol-Myers Squibb Co said on Thursday its immunotherapy Opdivo (nivolumab) failed to meet the main goal of a late-stage trial testing it in patients with an aggressive form of tumor that affects the brain or the spine.
Reuters Health Information

Denver Votes to Become First U.S. City to Decriminalize 'Magic Mushrooms'

Fri, 10 May 2019 15:27:02 +0000

Denver will become the first city in the United States to decriminalize magic mushrooms, based on final unofficial results on Wednesday of a ballot initiative about the hallucinogenic drug.
Reuters Health Information

Podimetrics Completes $13.4 Mln Funding for Disease-Detecting Foot Mat

Fri, 10 May 2019 15:27:12 +0000

Podimetrics, the maker of a smart foot mat that detects warning signs of diabetic foot ulcers, said on Thursday it raised $13.4 million in a funding round led by a group of investors, including venture capital firm Scientific Health Development.
Reuters Health Information

Numerous New Anticancer Drugs Not Proven Superior to Standard of Care

Fri, 10 May 2019 15:35:59 +0000

Seventeen percent of randomized controlled trials that led to new anticancer drug approvals in the U.S. had suboptimal control arms and did not prove superiority to standard-of-care treatments, a quality-improvement study shows.
Reuters Health Information

Trump Slams Drugmakers, Vows to Let U.S. States Buy Cheaper Medicines Abroad

Fri, 10 May 2019 15:53:27 +0000

U.S. President Donald Trump slammed the pharmaceutical industry for high prices of prescription drugs on Thursday and vowed to allow U.S. states to buy medicines from other countries if they cost less.
Reuters Health Information

AHA Abx Prophylaxis Guidelines Hit Moderate-Risk Target

Fri, 10 May 2019 14:36:19 +0000

A Canadian analysis suggests the guidelines on antibiotic prophylaxis are having their intended effect, but also identified increasing rates of infective endocarditis it says are unrelated.
Medscape Medical News

Physician Moms With Babies Escorted From ACOG Meeting Hall

Fri, 10 May 2019 11:03:19 +0000

Mothers with infants were asked to leave the exhibit hall of the American College of Obstetricians and Gynecologists (ACOG) 2019 Annual Meeting. Backlash on social media prompted a policy change.
Medscape Medical News

Men an Afterthought in Infertility Evaluation

Fri, 10 May 2019 10:18:18 +0000

Focus-group research shows that resources are geared toward women. Because men's physical status and psychological needs are often overlooked, women could be undergoing unnecessary IVF cycles.
Medscape Medical News

US Prescriptions Hit New High in 2018, but Opioid Scripts Dip

Fri, 10 May 2019 07:10:23 +0000

Americans filled 5.8 billion prescriptions in 2018, but prescriptions for opioids had the largest single-year drop ever recorded.
Medscape Medical News

Best and Worst States, Cities for Physicians to Thrive: Survey

Fri, 10 May 2019 07:40:04 +0000

A new Medscape survey shows the best and worst places for physicians to live and work, based on 14 categories.
Medscape Medical News

[Viewpoint] On results reporting and evidentiary standards: spotlight on the Global Fund

Thu, 09 May 2019 23:00:09 +0000

Since its inception in 2002, the Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) has disbursed more than US$39 billion across 120 countries. Funding provided by donors, mainly the USA, France, the UK, Germany, and Japan, has undoubtedly affected the lives of millions of people. As the Global Fund approaches its Sixth Replenishment Conference—to be held in France in October, 2019—the recently published results report1 appears to make a compelling case for further investment.

[Review] Iran in transition

Thu, 09 May 2019 23:00:09 +0000

Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades.

[Clinical Picture] Rapidly changing ECG in hyperkalaemia after succinylcholine

Thu, 09 May 2019 23:00:09 +0000

A 58-year-old man was hospitalised in our intensive care unit for severe, acute respiratory distress syndrome caused by an influenza virus infection. After 31 days, he was gradually weaned off mechanical ventilation. However, on the day after extubation, he had to be reintubated because of further respiratory distress. Emergency intubation was performed after rapid sequence induction using the short-acting anaesthetic agent etomidate, intravenously, at a dose of 0·3 mg/kg, and the muscle relaxant succinylcholine, intravenously, at a dose of 1 mg/kg.

[Articles] Maternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and meta-analysis

Thu, 09 May 2019 23:00:09 +0000

Maternal deaths and perinatal deaths following caesarean sections are disproportionately high in LMICs. The timing and urgency of caesarean section pose major risks.

[Articles] Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Thu, 09 May 2019 23:00:09 +0000

This study provides a comprehensive picture of the potential impact of suboptimal diet on NCD mortality and morbidity, highlighting the need for improving diet across nations. Our findings will inform implementation of evidence-based dietary interventions and provide a platform for evaluation of their impact on human health annually.

[Articles] Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcin

Thu, 09 May 2019 23:00:09 +0000

In locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma, perioperative FLOT improved overall survival compared with perioperative ECF/ECX.

[Articles] Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Thu, 09 May 2019 23:00:09 +0000

Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease.

[Department of Error] Department of Error

Thu, 09 May 2019 23:00:09 +0000

Wright S, Mabejane R. The 2019 UN high-level meeting on universal health coverage. Lancet 2019; 393: 1931—In this Correspondence, the authors' affiliation was mistakenly written as “Civil Society Engagement Mechanism for UHC2013 Secretariat” instead of “Civil Society Engagement Mechanism for UHC2030 Secretariat”. This correction has been made to the online version as of May 9, 2019, and the printed version is correct.

[Department of Error] Department of Error

Thu, 09 May 2019 23:00:09 +0000

van Dijk AH, Wennmacker SZ, de Reuver PR, et al. Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel-arm, non-inferiority trial. Lancet 2019; published online April 26. http://dx.doi.org/10.1016/S0140-6736(19)30941-9—In this Article, the name of the co-author “Klass H in het Hof” should be “Klaas in ‘t Hof”. This correction has been made to the online version as of May 9, 2019.

[Department of Error] Department of Error

Thu, 09 May 2019 23:00:09 +0000

Heerspink HJL, Parving H-H, Andress DL, et al. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial. Lancet 2019; 393: 1937–47—In table 2, the upper limit of the 95% CI for the hazard ratio for the cardiorenal composite endpoint has been corrected to 0·999. This correction has been made to the online version as of May 9, and the printed version is correct.

[Department of Error] Department of Error

Thu, 09 May 2019 23:00:09 +0000

Zhong D, Yi Y, Lin C. A kidney changes size: first increasing and then decreasing. Lancet 2019; 393: 1641—In this Clinical Picture, the authors' affiliation and corresponding author's address have been corrected to “Department of Urology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan 364000, China”. These corrections have been made to the online version as of May 9, 2019.

[Department of Error] Department of Error

Thu, 09 May 2019 23:00:09 +0000

Chu DK, Wood RA, French S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet 2019; published online April 25. http://dx.doi.org/10.1016/S0140-6736(19)30420-9—In this Article, the URL to the online interactive summary of findings in the third paragraph of the Results section has been corrected. This correction has been made to the online version as of April 29, 2019.

[Correspondence] A stitch in time saves nine

Thu, 09 May 2019 23:00:09 +0000

Jeroen de Filette and Vincent Michiels (Sept 29, 2018, p E9)1 report a bleeding due to a drug–drug interaction between warfarin and fluconazole. Inhibition of warfarin's primary metabolic enzyme cytochrome P450 (CYP) 2C9 is mentioned as the main cause. CYP 2C9 is responsible for the metabolism of the S-warfarin enantiomer.2 Additionally, the concentration of the less active R-warfarin enantiomer will also increase due to inhibition of CYP 3A4 and 2C19 by fluconazole, thereby contributing to the increased international normalised ratio.

[Correspondence] Trial (management) and error

Thu, 09 May 2019 23:00:09 +0000

Ian Roberts (Sept 1, 2018, p 732)1 presented a parody of clinical trial research, which contributed a voice for trial managers to broaden discussions about gender inequality and role recognition. Humour serves to illustrate the challenge trial managers can experience: their contribution to the successful delivery of what can often be complex clinical trials is frequently underestimated and unrecognised. However, it should also be noted that this is not, or not solely, a gender issue.

[Correspondence] Drug-coated balloons: room for development of BASKET-SMALL 2 – Authors' reply

Thu, 09 May 2019 23:00:09 +0000

Fernando Alfonso and colleagues address some methodological issues in the BASKET-SMALL 2 study.1 They are correct in highlighting that patients were enrolled over a 5-year period, between April 10, 2012, and Feb 1, 2017, in 14 participating centres. However, this duration was not due to selection bias, and can easily be explained by the fact that centres did not start enrolment simultaneously. Eligible centres were difficult to find because of the little financial compensation in this investigator-initiated study, and because the initially used drug-eluting stents in the trial were withdrawn from the market and had to be replaced by another drug-eluting stent after enrolment of 94 (28%) of 341 patients in the per protocol population, which made an increase in sample size necessary.

[Correspondence] Drug-coated balloons: room for development of BASKET-SMALL 2

Thu, 09 May 2019 23:00:09 +0000

We read with great interest the results of the BASKET-SMALL 2 trial by Raban Jeger and colleagues.1 According to their protocol, “All patients with an indication for PCI [percutaneous coronary intervention] either due to acute coronary syndrome, chronic angina pectoris, or silent ischemia, and angiographic lesions in native coronary arteries with a diameter of 2 mm to less than 3 mm were eligible for enrolment”. Stable angina was the indication in 544 (72%) of the 758 patients assigned to receive drug-coated balloons (DCB) or drug-eluting stents (DES).

[Correspondence] Drug-coated balloons: room for development of BASKET-SMALL 2

Thu, 09 May 2019 23:00:09 +0000

We read with interest the BASKET-SMALL 2 randomised study by Raban Jeger and colleagues (Sep 8, 2018, p 849),1 which provided compelling clinical evidence of the efficacy of drug-coated balloons in patients with de-novo lesions in small coronary vessels. Because of the clinical implications of this trial, the first powered for clinical events in small coronary vessels, we feel that addressing some of the methodological issues will be of major scientific value. First, small vessels (<3 mm on visual assessment) account for up to a third of coronary interventions in clinical practice;2 therefore, the 5-year time period needed to complete patient enrolment in this multicentre (14 sites) study suggests the possibility of selection bias.

[Correspondence] Biodegradable-polymer stents versus durable-polymer stents – Authors' reply

Thu, 09 May 2019 23:00:09 +0000

The BIOSCIENCE trial1 was powered to assess non-inferiority for the primary outcome of target lesion failure at 12 months. Biodegradable-polymer siroliumus-eluting stents were found to be non-inferior to durable-polymer sirolimus-eluting stents because the upper limit of the one-sided 95% CI of the absolute risk difference at 12 months was smaller than 3·5%.1 Since no further non-inferiority analyses were planned, we carefully refrained from claims of non-inferiority in the analyses of 5-year outcomes and only included rate ratios (RRs) with two-sided 95% CIs and two-sided p values for superiority.

[Correspondence] Biodegradable-polymer stents versus durable-polymer stents

Thu, 09 May 2019 23:00:09 +0000

In their randomised trial, Thomas Pilgrim and colleagues (Aug 28, 2018, p 737)1 assessed the non-inferiority of ultrathin-strut biodegradable-polymer sirolimus-eluting stents to thin-strut durable-polymer erolimus-eluting stents. The rate ratio (RR) for the primary composite outcome of target lesion failure (biodegradable-polymer stents vs durable-polymer stents) was 1·07 (95% CI 0·88–1·31; p=0·487). On the basis of this quantification, the two stents were claimed to be similar. However, the RR does not capture the temporal profile of event occurrences.

[Correspondence] Trend analysis of diabetic mortality – Authors' reply

Thu, 09 May 2019 23:00:08 +0000

We appreciate Xiaoling Yuan and colleagues' Correspondence about our Article.1 We used age adjustment instead of age standardisation because we considered it to be more efficient and appropriate to account for the reduced power in younger age strata in the context of discretised Poisson regression models, which we used to transform serial cohorts into nationally representative, year-specific estimates. Our analyses also modelled mortality trends as a continuous variable and evaluated non-linear terms, in addition to presenting point estimates at 10-year intervals.

[Correspondence] Trend analysis of diabetic mortality

Thu, 09 May 2019 23:00:08 +0000

We read with great interest the Article by Edward Gregg and colleagues (June 16, 2018, p 2430).1 Here, we note some of our concerns on the methodology.

[Correspondence] The 2019 UN high-level meeting on universal health coverage

Thu, 09 May 2019 23:00:08 +0000

In their discussion of universal health coverage (UHC), the Editors (Jan 5, p 1)1 rightly state that “simply convening a UN high-level meeting is not enough” to achieve UHC. The Civil Society Engagement Mechanism for UHC2030 (CSEM) strongly agrees and is concerned that, without a radically different approach, the meeting will be a business-as-usual global health event. We are concerned that speakers at the high-level meeting on UHC on Sept 23, 2019, will declare support for UHC and leaving no one behind, but will not be held to account for their contradictory policies and actions.

[Obituary] James Lance

Thu, 09 May 2019 23:00:08 +0000

Neurologist who specialised in headache and motor control. Born in Wollongong, NSW, Australia, on Oct 29, 1926, he died of acute leukaemia in Sydney, NSW, Australia, on Feb 20, 2019, aged 92 years.

[Perspectives] Eglantyne Jebb and the war against children

Thu, 09 May 2019 23:00:08 +0000

This year, on May 16, Save the Children is 100 years old. It is the second oldest humanitarian organisation in the world (the International Committee of the Red Cross is the oldest), and the largest to focus entirely on the welfare of the child. Not only has it saved the lives of millions of children, it has helped transform the way we think about the nature of childhood itself.

[Perspectives] Mike Grocott: climbing high in critical care medicine

Thu, 09 May 2019 23:00:08 +0000

Besides his clinical and academic roles as Professor of Anaesthesia and Critical Care Medicine at the UK's University of Southampton, Mike Grocott is director of the Xtreme Everest Oxygen Research Consortium, a group of doctors, nurses, and scientists who use research done at high altitude to improve the treatment of critically ill patients. During his childhood, Grocott's family holidays were mostly in Scotland, the Lake District, and north Wales. “Mountains were a part of growing up and family life”, he recalls.

[Perspectives] In pursuit of polymathy

Thu, 09 May 2019 23:00:08 +0000

Medicine, despite its penchant for specialism, has always been responsive to polymathy. In ancient Egypt, Imhotep—most famous as the architect of the Step Pyramid—was also a physician, worshipped as the god of medicine and linked with the ancient Greek god of medicine, Asclepius, mentioned in the Hippocratic oath. Imhotep was the real “Father of Medicine”, wrote William Osler in the 19th century, as quoted by Waqās Ahmed in The Polymath: Unlocking the Power of Human Versatility. Other notable historical examples are Avicenna (Ibn Sina), the Persian physician from the 11th-century Islamic golden age, who wrote on astronomy, geography, mathematics, physics, and philosophy, as well as works of poetry, and Leonardo da Vinci, who pursued not only painting but many other disparate subjects, including anatomy.

[Perspectives] Body of thought

Thu, 09 May 2019 23:00:08 +0000

“It happened quickly, an inverse magician's trick: now you don't see it, now you do.” This is how Sinéad Gleeson's body announced itself to her when she was 13 years old, as she describes in Blue Hills and Chalk Bones, the opening essay in her debut collection of prose and poetry Constellations: Reflections from Life. Her previously normal, active life was consumed by pain emanating from her left hip. The eventual diagnosis was monoarticular arthritis, but getting to that point took some time, and finding actual relief from the condition even longer.

[World Report] Legal battles over abortion heat up in the USA

Thu, 09 May 2019 23:00:08 +0000

Changes to Title X, several legal challenges, and a change to the Supreme Court composition could mean drastic changes for access to abortion in the USA. Susan Jaffe reports.

[Comment] Offline: Time to radically rethink non-communicable diseases

Thu, 09 May 2019 23:00:08 +0000

The strategies that underpin global health orthodoxy today, expressed as an almost exclusive concern with Sustainable Development Goal (SDG) 3, will fail to deliver healthy lives for all. Few global health institutions or initiatives acknowledge this reality. The Global Fund to Fight AIDS, Tuberculosis and Malaria is unlikely to divert from its narrow disease-driven narrative in the run up to its October, 2019, replenishment conference in Lyon. Gavi, The Vaccine Alliance, sees vaccination as an important contributor to the SDGs.

[Comment] UK Public Health Science 2019: a call for abstracts

Thu, 09 May 2019 23:00:08 +0000

In the current climate of political uncertainty in the UK and abroad, public health voices that champion equity, sustainability, and the long-term view can struggle to make themselves heard. Generating and implementing evidence that draws on insights from a diversity of research disciplines and that is relevant to policy and practice across societies is more important than ever. We, therefore, welcome abstract submissions for Public Health Science 2019: A National Conference Dedicated to New Research in UK Public Health, to be held in London, UK, on Nov 29, 2019.

[Comment] Improving access to caesarean sections and perioperative care in LMICs

Thu, 09 May 2019 23:00:08 +0000

The percentage of people with no access to surgery is 97% in low-income countries, compared with 14% in high-income counties.1 Although the dramatic rise in the number of caesarean sections has been a major concern in high-income countries, inequities in the use of caesarean sections between countries persist, with certain countries in Africa having a caesarean section prevalence as low as 2%.2 WHO warns that inadequate access to a timely caesarean section might result in perinatal asphyxia, stillbirth, uterine rupture, and obstetric fistula.

[Comment] Global diet and health: old questions, fresh evidence, and new horizons

Thu, 09 May 2019 23:00:08 +0000

Few, if any, would contest that diet and nutrition have a crucial and substantial impact on human health. But the devil is in the details. Common questions include: is there such a thing as an optimal diet? What is suboptimal? Which dietary components matter most? And given the necessity to take action on climate change and planetary health, what should the world eat?1 The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) contributes towards answering these questions by estimating the burden of mortality and disability attributable to specific dietary risks, within a comparative risk assessment framework that currently considers 84 behavioural, environmental, occupational, and metabolic risks across 195 countries and territories.

[Comment] A turning point for chronic kidney disease in diabetes

Thu, 09 May 2019 23:00:08 +0000

The worldwide prevalence of chronic kidney disease is one in seven to one in ten adults.1,2 This pandemic is closely linked to a global diabetes emergency.3 In 2017, 425 million adults had diabetes, with a projection for a 48% increase to 629 million by 2045.3 About half of those with diabetes develop chronic kidney disease.4 Progressive chronic kidney disease eventuates in end-stage kidney disease requiring dialysis or kidney transplantation to sustain life. However, only about 10% of patients survive to end-stage kidney disease because of premature death, predominantly from cardiovascular diseases and infections.

[Editorial] Research futures—from 2019 to 2029

Thu, 09 May 2019 23:00:08 +0000

What will the world of research look like in 2029? How will research be funded? What are the pathways to open science? How will researchers work, and what will be the role of technology? How will the research information system change, and what will education look like? On May 2, at a conference organised by the European Health Forum Gastein, and hosted by Wellcome in London (UK), possible drivers shaping the future of research were outlined.

[Editorial] Malaysia's Pain Free programme

Thu, 09 May 2019 23:00:08 +0000

At the Annual Scientific Meeting of the Australia and New Zealand College of Anaesthetists in Kuala Lumpur (Malaysia) last week, Dr Mary Suma Cardosa, pain specialist at Hospital Selayang and President of the Malaysian Association for the Study of Pain, presented over a decade of work in Malaysia addressing pain. Cardosa described how adoption of “pain as the fifth vital sign” in 2008 improved awareness of pain in hospitals but did not lead to significant practice change. The Pain Free Hospital campaign was subsequently initiated in Malaysia's public health system in 2011, and extended to include primary care and dental services in 2017.

[Editorial] Net zero by 2050 in the UK

Thu, 09 May 2019 23:00:08 +0000

The Committee on Climate Change (CCC), an independent body that advises the UK Government, published a report on May 2, Net zero—the UK's contribution to stopping global warming. Stating that net zero is “necessary, feasible, and cost-effective”, the CCC set a target year of 2050 for complete elimination of greenhouse gas (GHG) emissions in the UK. The report provides a comprehensive framework for multiple sectors that the government could feasibly adopt to adhere to the 2015 Paris Agreement and Intergovernmental Panel on Climate Change (IPCC) limits of 1·5–2·0 degrees global warming from pre-industrial levels by 2050.

FDA Panel Recommends Mannitol Inhalation Powder for CF

Thu, 09 May 2019 17:59:08 +0000

An FDA panel voted 9 to 7 to recommend mannitol inhalation powder (Bronchitol, Chiesi) for improvement of pulmonary function in adults with cystic fibrosis, along with standard therapies.
Medscape Medical News

Video Game May Help Identify Preclinical Alzheimer's

Thu, 09 May 2019 16:32:16 +0000

Spatial navigation ability as measured by a virtual reality computer game can potentially identify people at high genetic risk of risk developing Alzheimer's disease.
Medscape Medical News

Hepatitis A Infections Up Nearly 300 Percent in Recent Years

Thu, 09 May 2019 16:39:52 +0000

Hepatitis A infections have risen almost 300 percent in recent years, the US Centers for Disease Control and Prevention reports.
Medscape Medical News

Maternal Genes Tied to ADHD Development in Children

Thu, 09 May 2019 15:32:10 +0000

Mothers at high genetic risk for attention-deficit/hyperactivity disorder (ADHD) and other neurodevelopmental disorders may also be at risk for adverse behaviors during pregnancy that could affect their child, according to a recent study.
Reuters Health Information

Results From Many Large Clinical Trials Remain Unpublished Years Later

Thu, 09 May 2019 15:23:38 +0000

Results from a substantial proportion of large, registered, randomized controlled trials (RCTs) can go unpublished for years after their completion, researchers report.
Reuters Health Information

US 'Emerging Adults' With Type 1 Diabetes Face DKA Danger

Thu, 09 May 2019 15:37:32 +0000

US-Canadian disparities are in part due to the "churn" that often happens as US adolescents move from pediatric to adult care versus Canada's "seamless" transition under universal care.
Medscape Medical News

Fundoplication Success in Laryngopharyngeal Reflux Hard to Assess

Thu, 09 May 2019 13:24:32 +0000

The heterogeneity among studies makes it "impossible" to reliably estimate the effectiveness of fundoplication in controlling laryngopharyngeal reflux disease, according to a review of more than 30 studies.
Reuters Health Information

Cholesterol-Lowering Drugs Tied to Reduced Glaucoma Risk

Thu, 09 May 2019 12:49:09 +0000

High cholesterol is associated with an increased risk of developing open-angle glaucoma, but a new study suggests taking statins to lower cholesterol helps to reduce this risk.
Reuters Health Information

Repetition Helps Preschoolers Learn to Eat Healthy Foods

Thu, 09 May 2019 13:18:59 +0000

By using the right words and repeating the phrases, adults can help young kids get over picky eating behaviors and eat healthier foods, according to a new study.
Reuters Health Information

Progesterone Only Prevents Miscarriage in Women With History of Pregnancy Loss

Thu, 09 May 2019 13:09:58 +0000

Giving progesterone to women with bleeding early in pregnancy doesn't prevent pregnancy loss, except among women who have had a previous miscarriage, according to a study of 4,153 women treated at 48 hospitals in the UK.
Reuters Health Information

'Ultra-Short' Iron Boost Day Before Cardiac Surgery Reduces RBC Transfusions

Thu, 09 May 2019 12:20:32 +0000

A combination treatment given to patients with anemia or iron deficiency the day before cardiac surgery significantly reduces their need for red blood cell (RBC) transfusions, according to new findings in The Lancet.
Reuters Health Information

LEGATO-HD: Laquinimod Misses Primary Aim in Huntington's

Thu, 09 May 2019 11:57:00 +0000

No significant changes on a clinical motor rating scale emerged after 1 year, but researchers report some intriguing differences on brain imaging.
Medscape Medical News

Trexit: A 'Clean Break' from Transrectal Prostate Biopsies

Thu, 09 May 2019 12:29:13 +0000

Unlike Brexit, Trexit is happening in a timely manner. In the UK, urologists are moving away from transrectal needle biopsies and taking up a transperineal approach, which has less risk for sepsis.
Medscape Medical News

Experience Rules: AF Ablation Risks Higher at Low-Volume Centers

Thu, 09 May 2019 09:49:23 +0000

Lowest-volume hospitals made up about 80% of those ablation centers in the analysis, yet their complication rates were the highest. Still, it probably isn't ablation experience alone affecting risk.
Medscape Medical News

'Vaginal Rejuvenation' Confusing for Patients and Physicians

Thu, 09 May 2019 10:16:32 +0000

Advertising and social media have led to confusion about the term, and physicians need to educate patients on which procedures are medically necessary, which are cosmetic, and which can be harmful.
Medscape Medical News

EXTEND Published: tPA Success Up to 9 Hours After Stroke

Thu, 09 May 2019 10:32:17 +0000

Using perfusion imaging to identify ischemic stroke patients with salvageable brain tissue looks to be the key to extending the window for thrombolysis out to 9 hours, the trial shows.
Medscape Medical News

Long-term Antibiotic Use Tied to Higher CVD Risk

Thu, 09 May 2019 09:10:37 +0000

Previous research suggests antibiotics may have an adverse effect on cardiovascular health. A new analysis of the Nurses' Health Study looks specifically at the effect of long-term use on CVD risk.
Medscape Medical News

Senators Seek Feedback on Medicare's Pay Models Under MACRA

Thu, 09 May 2019 06:57:38 +0000

Lawmakers are keeping tabs on changes that may be needed in Medicare's MIPS and APM programs, although no major revisions are likely soon.
Medscape Medical News

For First Time, More Doctors Employed Than Self-Employed: AMA

Thu, 09 May 2019 07:31:21 +0000

The AMA report said that it’'s not a given that current trends will continue.
Medscape Medical News

Kaiser Launches Online Network to Address Patients' Social Needs

Wed, 08 May 2019 19:53:43 +0000

The HMO aims to connect its providers with community services on behalf of its 12.3 million members; it will open up the platform to as many as 68 million people.
Medscape Medical News

Nearly Half of US Population Takes Prescription Drugs

Wed, 08 May 2019 19:59:04 +0000

The most commonly prescribed drugs are bronchodilators in young children, stimulants in adolescents, and antidepressants and lipid-lowering drugs in adults.
Medscape Medical News

Novel Treatment for Huntington's Shows Early Promise

Wed, 08 May 2019 18:53:55 +0000

The first-in-human trial of investigational agent RG6042 (aka, HTTRx) provides details about safety and other factors behind its potential in early Huntington's disease.
Medscape Medical News

Heart Failure Deaths Rising in U.S., Especially Among Younger Adults

Wed, 08 May 2019 17:29:33 +0000

More U.S. adults are dying from heart failure today than a decade ago, and the sharpest rise in mortality is happening among middle-aged and younger adults, a new study suggests.
Reuters Health Information

Arsenic Exposure Linked to Heart Thickening

Wed, 08 May 2019 17:12:04 +0000

Drinking water that is contaminated with even moderate levels of arsenic may lead to an increase in left ventricular wall thickness and LV hypertrophy, a new U.S. study suggests.
Reuters Health Information

Coca-Cola Contracts Allow Research to Be Suppressed, Says Report

Wed, 08 May 2019 16:53:20 +0000

Coca-Cola's "transparency initiative was window dressing," says a study author. "They're still trying to do everything they can to evade their responsibility for their role in the global obesity epidemic."
Medscape Medical News

HHS Finalizes Rule Requiring Prices in TV Drug Ads

Wed, 08 May 2019 16:27:11 +0000

The new rule allows pharmaceutical companies to sue their rivals if they fail to make an adequate disclosure in an advertisement.
Medscape Medical News

Skipping Surgery for HER2+ Breast Cancer: Which Patients?

Wed, 08 May 2019 15:11:11 +0000

New findings have identified factors associated with pathological complete response (pCR) following neoadjuvant treatment, which will help identify patients who could skip surgery.
Medscape Medical News

Circadian Clock Plays a Role in Health, Peak Performance

Wed, 08 May 2019 15:44:32 +0000

Emerging research on exercise, circadian rhythms, and sleep, and their effects on an athlete's performance, is becoming integrated into sports medicine.
Medscape Medical News

Coca-Cola имеет возможность прерывать и отзывать невыгодные исследования о здоровье

Wed, 08 May 2019 21:16:18 +0000

Исследование более 87000 документов показало механизм заключения контрактов, позволяющий компании Coca-Cola «аннулировать» результаты некоторых исследований в области здравоохранения, которые компания финансирует в университетах США и Канады.

Changing Patterns of HPV Oral Cancer in US White Men

Wed, 08 May 2019 14:20:46 +0000

Incidence rates are slowing in younger white men, while they are rapidly increasing in those aged 60 years and older.
Medscape Medical News

Big Data Reveal Actionable Findings to Prevent Disease

Wed, 08 May 2019 14:27:03 +0000

Results from a longitudinal, big data cohort study that included multiomics and enhanced clinical testing led to actionable diagnoses for more than half of patients.
Medscape Medical News

Mistreated Medical Students: A Cultural Shift Is Underway

Wed, 08 May 2019 14:29:57 +0000

Abuse is passed down in a culture of exploitation. 'High stakes' specialties like internal medicine, surgery, and obstetrics tend to see more cases, but some students are reporting it.
Medscape Medical News

Вес до беременности может говорить о возможности осложнений

Wed, 08 May 2019 20:51:37 +0000

Будущие мамы и врачи много внимания уделяют набору веса во время беременности, однако вес до беременности может быть гораздо важнее, как показывает новое исследование, опубликованное в Journal of the American Medical Association.

High Tech Lymphedema Surveillance Helps Prevent Progression

Wed, 08 May 2019 13:03:44 +0000

A device that measures intracellular fluid volume was more effective than standard methods in identifying subclinical lymphedema and initiating earlier treatment.
Medscape Medical News

Premature Birth Ups Risk of Kidney Disease Into Adulthood

Wed, 08 May 2019 12:11:23 +0000

Prematurity is associated with a greater risk of developing chronic kidney disease into mid-adulthood, and preventive action is needed for all babies born earlier than full term.
Medscape Medical News

Are You Seeing Measles in Your Practice?

Wed, 08 May 2019 10:03:02 +0000

Confirmed measles cases have reached the highest levels this century.
Medscape Reader Polls

Low Glucose on Last Day in Hospital Link to Death in Diabetes

Wed, 08 May 2019 10:25:23 +0000

Hypoglycemia or severe hypoglycemia 24 hours before discharge is linked to increased mortality and readmission rates in hospitalized patients with diabetes.
Medscape Medical News

Few Cardiologists Referring Patients for Palliative Care

Wed, 08 May 2019 10:27:23 +0000

Palliative care is not just for patients at the end of life but can be helpful at any stage of a serious or life-changing illness, authors of a new study stress.
Medscape Medical News

Good Nutrition Essential for Healthy Aging

Wed, 08 May 2019 10:43:56 +0000

'What we eat contributes to both disease and wellness,' says one expert, but as people age, access to nutritious food can become a challenge. Geriatricians can help with that.
Medscape Medical News

Compounded Bioidentical Hormone Replacement Scrutinized

Wed, 08 May 2019 07:56:13 +0000

An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine held its second information gathering session on compounded bioidentical hormone replacement therapy.
Medscape Medical News

FDA OKs First Treatment for Children With LEMS

Wed, 08 May 2019 07:02:39 +0000

Amifampridine (Ruzurgi) is an oral potassium channel blocker indicated for children and adolescents aged 6 years to less than 17 years with the rare autoimmune disease.
FDA Approvals

Показатели шкалы Апгар в пределах нормальных связали с риском болезней и смерти

Wed, 08 May 2019 13:34:46 +0000

Показатели 7, 8 и 9 по шкале Апгар, которые считаются нормальными, связаны с более высокими рисками болезни и даже смерти для новорожденных по сравнению с «идеальным» показателем 10. Статью, которая высказывает опасения по этому поводу, шведские ученые опубликовали в British Medical Journal.

Prepregnancy BMI Tied to Risk for Poor Maternal-Fetal Outcomes

Tue, 07 May 2019 20:31:27 +0000

Prepregnancy BMI may be a more important factor for adverse maternal and fetal outcomes than gestational weight gain, a new analysis suggests.
Medscape Medical News

CDC: 700 Pregnancy-Related Deaths Annually, Most Preventable

Tue, 07 May 2019 19:24:06 +0000

Three in five pregnancy-related deaths in US women could be prevented by addressing community, health facility, patient, provider, and system-level factors.
Medscape Medical News

European Commission OKs Dupilumab for Severe Asthma

Tue, 07 May 2019 18:19:34 +0000

Dupilumab is for patients with moderate-to-severe asthma and increased blood eosinophil and/or raised fractional exhaled nitric oxide levels poorly controlled with other medicines.
International Approvals

Novel Drug Eases Charcot-Marie-Tooth Disability in Phase 3 Trial

Tue, 07 May 2019 17:23:29 +0000

A novel, fixed-dose, three-drug combination therapy has provided "first evidence of meaningful improvement" in patients with Charcot-Marie-Tooth Type 1A disease in a new phase 3 trial.
Medscape Medical News

Immunotherapy Using Donor Cells Safe in PML

Tue, 07 May 2019 17:36:09 +0000

Pilot results in a small number of patients with PML suggests safety of an approach using adoptive cellular immunotherapy generated from cells taken from a healthy related donor.
Medscape Medical News

FDA to End Program That Hid Reports on Faulty Medical Devices

Tue, 07 May 2019 15:46:57 +0000

The agency will open past records to the public in the coming weeks. A former FDA official said ending the practice of concealing these reports of harm is "a victory for patients and consumers."
Kaiser Health News

Brain Healthy Behaviors Aid Patients With MCI, Mild Dementia

Tue, 07 May 2019 16:09:52 +0000

A unique, easily implemented, low-cost coaching program appears to improve adherence to brain healthy behaviors in patients with MCI, mild dementia, and subjective memory problems, early research suggests.
Medscape Medical News

FDA Alert, Medtronic Pacemaker Battery Failure Without Warning

Tue, 07 May 2019 15:12:59 +0000

Capacitor failure in several Medtronic standard and biventricular pacemaker models could lead to early battery drain; FDA has received three such reports, one of which involved a patient death.
News Alerts

As Melanoma Rises, Doctors Challenge Some Early Testing

Tue, 07 May 2019 15:32:54 +0000

As melanoma cases continue to rise sharply, some dermatologists question whether screening people without symptoms has resulted in overdiagnosing melanoma, bringing unnecessary anxiety and treatments.
WebMD Health News

Родители часто курят электронные сигареты при детях

Tue, 07 May 2019 20:08:22 +0000

Родители, использующие электронные сигареты, часто курят при детях, подвергая их вторичному вдыханию дыма, то есть пассивному курению. Дым от вейпинга может оказаться столь же вредным, как дым сигарет, говорится в новом американском исследовании, которое опубликовано в журнале JAMA Pediatrics.

AUA Releases First Uncomplicated Recurrent UTI Guideline

Tue, 07 May 2019 13:10:17 +0000

Antibiotic stewardship is a strong theme of the guideline issued by the American Urological Association (AUA). Cranberry gets a conditional recommendation for nonantibiotic prophylaxis.
Medscape Medical News

High-Dose Radiotherapy Boosts Survival Rate in Mesothelioma

Tue, 07 May 2019 13:46:17 +0000

Patients who underwent nonradical surgery and received high doses of radiotherapy were twice as likely to be alive at 2 years compared to those who received palliative radiotherapy.
Medscape Medical News

Компоненты солнцезащитного крема обнаруживаются в крови в высоких концентрациях

Tue, 07 May 2019 19:28:41 +0000

Интенсивное использование солнцезащитной продукции приводит к заметному повышению уровня в крови человека химических веществ, содержащиеся в этих средствах, что вызывает опасения по поводу потенциальных токсических эффектов, согласно новому исследованию Управления по санитарному надзору за качеством пищевых продуктов и медикаментов США.

Serum Steroid Precursors May Aid in Adrenal Disease Diagnoses

Tue, 07 May 2019 11:53:24 +0000

Tests that are already available in commercial reference labs can aid in common diagnostic challenges when working up patients with adrenal tumors and in differentiating subtypes of Cushing syndrome.
Medscape Medical News

Dedicated Teams Keep Seniors Out of Hospital

Tue, 07 May 2019 12:49:26 +0000

Programs focused on the needs of elderly patients can reduce visits to the emergency department and keep seniors who have been discharged from the hospital from being readmitted, new data show.
Medscape Medical News

Packing a PUNCH in Prostate Cancer: Chemo & ADT & Surgery

Tue, 07 May 2019 10:43:14 +0000

Investigators of the Preoperative Use of Neoadjuvant Chemotherapy (PUNCH) trial say that this experimental approach should now be a standard in high-risk, localized disease. An expert rejects the idea.
Medscape Medical News

Physicians Often Considered Cost in Treatment Decisions

Tue, 07 May 2019 10:03:46 +0000

Physicians often take cost into account when prescribing medications or treatment, yet many are reluctant to initiate a discussion about it with patients, a new survey finds.
Medscape Medical News

Metronidazole Shrinks Endometriosis Via Microbiota (in Mice)

Tue, 07 May 2019 10:09:09 +0000

"Our initial goal was to understand how these gut bacteria...might be connected to endometriosis, but...we may have found a cost-effective treatment," said the senior author of a study in mice.
Medscape Medical News

Homelessness in Infancy Has Lasting Health Effects in Kids

Tue, 07 May 2019 09:49:10 +0000

Children who experienced homelessness or housing instability in infancy had higher rates of asthma, more emergency department visits, and higher healthcare costs through age 6 years.
Medscape Medical News

Physicians Starting to Claim Climate Change Is 'In My Lane'

Tue, 07 May 2019 07:31:35 +0000

Clinicians recently gathered at a conference outside Washington, DC, to focus on climate change and its impacts on health -- and to learn what they can do about it.
Medscape Med Students

Растительная диета может защитить почки

Tue, 07 May 2019 12:38:17 +0000

Согласно новому американскому исследованию, растительная диета связана со снижением риска заболевания почек. Но люди, которые потребляют много крахмала и сладкой вегетарианской пищи, могут оказаться более подверженными нефрологической патологии. Результаты были опубликованы в Clinical Journal of the American Society of Nephrology.

PFO Tied to Quadruple Stroke Risk in Pulmonary Embolism

Mon, 06 May 2019 17:16:09 +0000

Screening PE patients for patent foramen ovale with the aim of identifying those at risk for ischemic stroke who may be eligible for indefinite anticoagulation could be justified, a new study suggests.
Medscape Medical News

FDA Finds High Systemic Absorption of Sunscreen Ingredients

Mon, 06 May 2019 17:38:39 +0000

Every patient in a standardized trial of sunscreens quickly reached systemic concentrations of the active ingredients that exceeded the level the FDA views as a trigger for systemic safety testing.
Medscape Medical News

Fournier Gangrene Alarm: More Cases Linked to Diabetes Drugs

Mon, 06 May 2019 17:02:15 +0000

Physicians prescribing SGLT2 inhibitors, a newer class of diabetes drugs, are advised to "have a high index of suspicion" about the potentially fatal complication.
Medscape Medical News

Once-Daily Opicapone Adds 'On Time' in PD Phase 3 Studies

Mon, 06 May 2019 15:50:39 +0000

A new COMT inhibitor in development with more convenient dosing is evaluated for safety and efficacy in people with Parkinson's disease and motor fluctuations.
Medscape Medical News

Marriage Duration May Influence Kids' Schizophrenia Risk

Mon, 06 May 2019 16:18:13 +0000

Known risk factors for schizophrenia include paternal age and family psychiatric history. This study suggests the duration of parental marriage may also play a role.
Medscape Medical News

Стресс перед экзаменами связан с переходом на вредную для здоровья диету

Mon, 06 May 2019 21:59:38 +0000

Во время экзаменов студенты сталкиваются с существенным стрессом, что может приводить к переходу на более вредное питание. За несколько недель плохой рацион может отразиться на здоровье, а после экзаменов отказаться от новых пищевых привычек может оказаться не так просто.

More Losartan Joins Recall List, Heritage Pharma Distributors

Mon, 06 May 2019 14:51:05 +0000

Manufacturer Vivimed has recalled 19 lots of its losartan potassium found with the same potential carcinogen that has led to recalls of both losartan and valsartan from various companies.
News Alerts

Heart Meds May Prevent Vascular Dementia After Stroke

Mon, 06 May 2019 15:05:25 +0000

Cilostazol and isosorbide mononitrate have neuroprotective potential after lacunar stroke, which carries a high risk for vascular dementia and cognitive decline.
Medscape Medical News

Cardiovascular Disease Leading Cause of Maternal Death

Mon, 06 May 2019 15:28:44 +0000

The American College of Obstetricians and Gynecologists has issued new recommendations for pregnant and postpartum women.
Medscape Medical News

Female Athletes at Greater Risk for Post-Concussion Injuries

Mon, 06 May 2019 14:15:06 +0000

Subsequent musculoskeletal injuries, especially knee and ankle sprains, are more likely to occur after a concussion in female collegiate athletes than in their male counterparts, new research suggests.
Medscape Medical News

AI Use in Healthcare lncreasing Slowly Worldwide

Mon, 06 May 2019 14:15:16 +0000

An international Medscape survey finds that just 20% of physicians say artificial intelligence (AI) has changed the way they practice, but 70% say it will eventually make their decisions more accurate.
Medscape Medical News

New AAN Guideline on Tourette Syndrome, Tic Disorders

Mon, 06 May 2019 14:15:32 +0000

The first guideline for US neurologists advocates Comprehensive Behavioral Intervention for Tics (CBIT) as first-line therapy for Tourette syndrome and other chronic tic disorders.
Medscape Medical News

Хорошая физическая подготовка снижает заболеваемость раком легкого и кишечника

Mon, 06 May 2019 20:47:08 +0000

Согласно крупному американскому исследованию, люди в хорошей физической форме значительно меньше рискуют заболеть раком легких и колоректальным раком. Кроме того, при высоком уровне физической подготовки до постановки диагноза, смертность от этих заболеваний была ниже.

Monstrous Rumors Stoke Hostility to Pakistan's Anti-Polio Drive

Mon, 06 May 2019 12:24:15 +0000

His bearded face was half-covered by a shawl, but Hameedullah Khan's fear and ignorance was on full display as he delivered a chilling message for anyone who tries to vaccinate his children against polio. "I will stab anyone who comes to my house with polio drops," Khan growled, refusing to be filmed or photographed as he shopped in a fly-blown bazaar on the outskirts of Peshawar, a city scarr...
Reuters Health Information

Congo Ebola Death Toll Nears 1,000, Expected to Spread -WHO

Mon, 06 May 2019 11:52:21 +0000

The World Health Organization said on Friday it feared continued "intense transmission" of Ebola virus in the Democratic Republic of Congo, where deaths from a nine-month-old epidemic is 994 and expected to exceed 1,000 within hours.
Reuters Health Information

Trump Admin. Proposal Would Make It Easier to Deport Immigrants Who Use Public Benefits

Mon, 06 May 2019 11:24:43 +0000

The Trump administration is considering reversing long-standing policy to make it easier to deport U.S. legal permanent residents who have used public benefits, part of an effort to restrict immigration by low-income people.
Reuters Health Information

Ice Slush in Kidney Cancer Surgery Is Ineffective

Mon, 06 May 2019 10:44:27 +0000

A first-of-its-kind clinical trial showed that use of soft ice to cool the kidney during open partial nephrectomy did not improve outcomes at 1 year. It's time to get to forgo the slush, investigators say.
Medscape Medical News

FDA OKs Two Tafamidis Formulations for Rare Cardiomyopathy

Mon, 06 May 2019 12:13:59 +0000

These are the first FDA-approved treatments for transthyretin-mediated amyloidosis cardiomyopathy, a rare and often fatal disease caused by deposition of amyloid fibrils in the myocardium.
FDA Approvals

In NYC Subway, CyberKnife Prostate Cancer Ads Mislead

Mon, 06 May 2019 12:19:43 +0000

Direct-to-consumer ads about the radiotherapy create 'inaccurate impressions,' according to the results of a consumer survey.
Medscape Medical News

U.S. Doctors Use Medical Records to Fight Measles Outbreak

Mon, 06 May 2019 11:06:01 +0000

U.S. doctors are tapping into their electronic medical records to identify unvaccinated patients and potentially infected individuals to help contain the worst U.S. measles outbreak in 25 years.
Reuters Health Information

Azithromycin May Reduce Treatment Failure for COPD Exacerbations

Mon, 06 May 2019 07:17:04 +0000

An extended course of low-dose azithromycin may significantly reduce treatment failure in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (COPD), new data suggest.
Medscape Medical News

«В метре друг от друга»

Mon, 06 May 2019 10:05:58 +0000

В российский прокат вышел фильм Джастина Бальдони «В метре друг от друга». Трогательная история любви двух подростков, больных генетическим заболеванием муковисцидозом, в то же время достаточно подробно описывает медицинскую сторону вопроса. МедНовости посмотрели фильм под этим углом зрения.

DUOGLOBE Interim Results: Intestinal Gel Cuts PD 'Off' Time

Sun, 05 May 2019 19:06:40 +0000

Researchers release additional results looking at levodopa-carbidopa intestinal gel to help lessen motor fluctuations and dyskinesia in people with advanced Parkinson's disease.
Medscape Medical News

Phones Could Help Guard Against Selfie Deaths, Medics Say

Sun, 05 May 2019 12:30:01 +0000

Smartphones might ironically be the answer to selfie-related deaths, two wilderness medicine specialists say.
Reuters Health Information

PREVENT: Eculizumab May Lower Relapse Risk in NMOSD

Sat, 04 May 2019 18:16:45 +0000

Use of eculizumab resulted in significantly greater relapse reduction over placebo in patients with neuromyelitis optica spectrum disorder (NMSOD), new findings from the phase 3 PREVENT trial show.
Medscape Medical News

Diabetic Teens With High Blood Sugar May Feel More Distress

Sat, 04 May 2019 14:24:52 +0000

Teens with type 1 diabetes may have more emotional distress from managing their condition when their blood sugar is high or they suffer from symptoms of depression, suggests a small study that advocates screening kids at risk for distress.
Reuters Health Information

Drug Company Founder, Execs Convicted of Bribe Scheme That Fueled U.S. Opioid Crisis

Sat, 04 May 2019 14:03:46 +0000

The founder of Insys Therapeutics Inc and four colleagues were found guilty on Thursday of bribing doctors to prescribe the drugmaker's addictive painkiller, helping to drive the U.S. opioid drug abuse crisis.
Reuters Health Information

City of Amsterdam to Ban Polluting Cars From 2030

Sat, 04 May 2019 13:51:50 +0000

Gasoline and diesel fueled cars and motorcycles will be banned from Amsterdam from 2030 in an effort to clean up the city's air, the Dutch capital's council said on Thursday.
Reuters Health Information

Loneliness a Common Health Threat for Older Adults

Sat, 04 May 2019 13:45:45 +0000

Loneliness is strongly linked to poor health and risk of death in older adults, but doctors can play an important role in identifying and addressing the problem, researchers say.
Reuters Health Information

High-Dose, Single-Fraction SBRT Likely Effective for Non-Spine Bone Metastases

Fri, 03 May 2019 20:48:19 +0000

Single-fraction stereotactic body radiotherapy (SBRT) seems to be an effective option for patients with painful non-spine bone metastases and achieved higher pain response rates than standard multifraction radiotherapy (MFRT) in a phase 2 noninferiority study.
Reuters Health Information

Maine Senate Rejects Ending Religious Exemptions for Vaccinations

Fri, 03 May 2019 20:44:18 +0000

An effort to end all non-medical exemptions for childhood vaccinations in Maine was in limbo on Thursday after the state Senate voted to amend it to allow parents to keep opting out on religious grounds.
Reuters Health Information

Happiness Training May Ease Dementia Caregivers' Anxiety, Depression

Fri, 03 May 2019 20:40:32 +0000

Much has been written about the stresses and emotional demands of caring for family members with dementia, and a new study suggests that some of this burden can be offset by training that helps caregivers focus on the positives of their experience.
Reuters Health Information

CV Research Spin Abundant in the Era of Alternative Facts

Fri, 03 May 2019 16:04:11 +0000

Such scientific lapses are distressingly common and may lead to further public distrust in science, which is already under attack globally.
Medscape Medical News

Oral Fluoroquinolones Carry Small Risk of Peripheral Neuropathy

Fri, 03 May 2019 15:43:16 +0000

Oral fluoroquinolone exposure is associated with a small increase in risk of peripheral neuropathy, according to findings from The Health Improvement Network (THIN) database.
Reuters Health Information

U.S. Health Agency Finalizes Conscience and Religious Freedom Rule

Fri, 03 May 2019 15:33:54 +0000

The U.S. Department of Health and Human Services on Thursday released a final rule allowing doctors, nurses and other health workers to opt out of procedures such as abortions and sterilizations which violate their personal or religious beliefs.
Reuters Health Information

Did CMS Policy Change Trigger a Spike in Illness Severity?

Fri, 03 May 2019 15:07:15 +0000

A study finds abrupt increases in measured severity of illness for hospitalized Medicare beneficiaries after the number of allowed secondary diagnosis codes expanded from 9 to 24 in 2011.
Medscape Medical News

Lp(a) Pegged as Aortic Stenosis Culprit and Treatment Target

Fri, 03 May 2019 12:57:33 +0000

Serial imaging showed it, and a lab experiment nailed it — at least in vitro. Elevations in two biomarkers further the progression of aortic valve calcification, and their inhibition might thwart it.
Medscape Medical News

FDA Allows Continued Sales of Textured Breast Implants

Fri, 03 May 2019 11:54:09 +0000

US regulators are considering additional steps, including adding a boxed warning, regarding risks of breast implants.
Medscape Medical News

No Edge for Levetiracetam Over Phenytoin for Status Epilepticus

Fri, 03 May 2019 11:15:42 +0000

Both levetiracetam and phenytoin are reasonable second-line treatment options for pediatric status epilepticus, new research shows.
Medscape Medical News

Old Malaria Drug as Good as Blockbuster Type 2 Diabetes Agent

Fri, 03 May 2019 09:41:52 +0000

When added to metformin and vildagliptin, hydroxychloroquine lowered HbA1c as well as canagliflozin and also reduced weight and inflammation.
Medscape Medical News

New Dementia Subtype That Mimics Alzheimer's Identified

Fri, 03 May 2019 10:21:11 +0000

Limbic-predominant age-related TDP-43 encephalopathy mimics Alzheimer's disease but is caused by TDP-43 protein deposits rather than beta-amyloid accumulation and is underrecognized.
Medscape Medical News

FDA Ban on Transvaginal Mesh for Prolapse Stirs Controversy

Fri, 03 May 2019 10:23:58 +0000

The ban on mesh for pelvic organ prolapse has elicited mixed reactions, but experts want to make clear that slings for stress urinary incontinence are not part of the ban.
Medscape Medical News

Watchful Waiting OK in Diabetic Macular Edema With Good Vision

Fri, 03 May 2019 09:21:21 +0000

New trial suggests no difference in risk for vision loss over 2 years with aflibercept, laser treatment, or observation; experts stress importance of adherence to follow-up and tight glycemic control.
Medscape Medical News

Diabetic Amputations a 'Shameful Metric' of Inadequate Care

Fri, 03 May 2019 06:45:13 +0000

In California, people who are black or Latino are more than twice as likely as whites to undergo amputations related to diabetes, a Kaiser Health News analysis found. The pattern is not unique to California.
Kaiser Health News

[The Lancet Commissions] The legal determinants of health: harnessing the power of law for global health and sustainable development

Thu, 02 May 2019 23:00:08 +0000

Health risks in the 21st century are beyond the control of any government in any country. In an era of globalisation, promoting public health and equity requires cooperation and coordination both within and among states. Law can be a powerful tool for advancing global health, yet it remains substantially underutilised and poorly understood. Working in partnership, public health lawyers and health professionals can become champions for evidence-based laws to ensure the public's health and safety.

[Clinical Picture] Acute renal and splenic infarctions as the initial manifestations of atrial fibrillation

Thu, 02 May 2019 23:00:08 +0000

A 73-year-old man with a history of hypertension and diverticulosis presented to our emergency department with a 1-day history of severe, lower abdominal pain, on his left side, associated with nausea. He did not report any other symptoms: dizziness, chest pain, palpitations, shortness of breath, haematuria, fever, or diarrhoea.

[Articles] Mapping diphtheria-pertussis-tetanus vaccine coverage in Africa, 2000–2016: a spatial and temporal modelling study

Thu, 02 May 2019 23:00:08 +0000

Despite substantial progress in Africa, marked national and subnational inequalities in DPT coverage persist throughout the continent. These results can help identify areas of low coverage and vaccine delivery system vulnerabilities and can ultimately support more precise targeting of resources to improve vaccine coverage and health outcomes for African children.

[Articles] Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

Thu, 02 May 2019 23:00:08 +0000

Genetic epidemiology shows that the apparently protective effects of moderate alcohol intake against stroke are largely non-causal. Alcohol consumption uniformly increases blood pressure and stroke risk, and appears in this one study to have little net effect on the risk of myocardial infarction.

[Articles] Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial

Thu, 02 May 2019 23:00:08 +0000

We found that the availability of PlGF test results substantially reduced the time to clinical confirmation of pre-eclampsia. Where PlGF was implemented, we found a lower incidence of maternal adverse outcomes, consistent with adoption of targeted, enhanced surveillance, as recommended in the clinical management algorithm for clinicians. Adoption of PlGF testing in women with suspected pre-eclampsia is supported by the results of this study.

[Correspondence] A call for academic medicine to remain politically neutral

Thu, 02 May 2019 23:00:08 +0000

We question the use of an important medical research paper as a platform for making a political statement. Dehghan and colleagues1 include “occupied Palestinian territory” as one of the 21 participant countries in their study. We presume this is referring to the areas that are described as West Bank and Gaza in official World Bank documents.2

[Correspondence] Social determinants of health: social justice and vested interests

Thu, 02 May 2019 23:00:08 +0000

I commend Kumanan Rasanathan (Oct 6, 2018, p 1176)1 for stressing the enduring inertia against efforts to tackle social injustice, despite it killing people on a grand scale. However, this inertia has not existed for a decade, but for more than half a century. In 1984, Marmot2 showed that individuals in the lowest socioeconomic status group were three times more likely to die of cardiovascular diseases than individuals in the highest socioeconomic group. This finding did not preclude the Progression of Early Subclinical Atherosclerosis study3 from investigating subclinical atherosclerosis (imaging, biomarkers, and genetics) in employees of a major bank headquarters in Madrid, Spain.

[Correspondence] Preventable brain injury in term labour

Thu, 02 May 2019 23:00:08 +0000

The Editors (Nov 24, 2018, p 2238)1 discuss preventable brain injury in term labour and highlight errors in interpreting, or failing to act on, abnormal cardiotocography results as a major modifiable risk factor. However, they did not mention the limitations of cardiotocography as a test to prevent intrapartum brain injury. In 1968, Benson,2 a pioneer in the development of cardiotocography, stated that cardiotocography is clinically useful at predicting intrapartum brain injury only at the extremes, with a normal trace usually indicating a normal fetus and a pathological trace indicating a fetus needing urgent delivery.

[Correspondence] Decriminalisation of recreational cannabis in South Africa

Thu, 02 May 2019 23:00:08 +0000

A South African Constitutional Court (ConCourt) ruling in September, 2018, upheld and extended the Western Cape High Court judgment, which found the criminalisation of home use and cultivation of cannabis by adults, as specified in the Drugs Act of 1992 and the Medicines Act of 1965, unconstitutional.1 Deputy Chief Justice Zondo stated that it will not be a criminal offence for an adult to use or be in possession of cannabis in a private place, although the amount a person can be in possession of will need to be decided by parliament.

[Correspondence] The MATRIX trial – Author's reply

Thu, 02 May 2019 23:00:08 +0000

I thank Torsten M Meyer and colleagues for discussing the hypothetical trade-off for radial access between reduced kidney injury1 after coronary catheterisation and the concerns of lower patency rates of the previously instrumented vessel if used as dialysis shunt. Yet, although the early benefits of radial access, including lower mortality, have been shown in large randomised trials and meta-analyses,2 that the radial artery, if used as an access site, might be associated with higher access failure of the dialysis shunt, remains unproven.

[Correspondence] The MATRIX trial

Thu, 02 May 2019 23:00:08 +0000

Marco Valgimigli and colleagues1 addressed the two most debated issues (anticoagulation and vascular access) in percutaneous coronary intervention and concluded that in patients with acute coronary syndrome, radial access should be the default approach because it decreases net adverse clinical events compared with femoral access.1

[Correspondence] The MATRIX trial

Thu, 02 May 2019 23:00:08 +0000

Marco Valgimigli and colleagues (Aug 25, 2018, p 835)1 did the largest randomised trial comparing radial versus femoral access for coronary angiography and concluded that radial access could become the default approach in patients with acute coronary syndrome undergoing invasive management. As nephrologists, we would to like add a word of caution.

[Correspondence] Social network theory and rising suicide rates in the USA – Author's reply

Thu, 02 May 2019 23:00:08 +0000

Tarun Bastiampillai and colleagues stress that proper understanding of an individual's social network could be important for suicide prevention. In support of this statement are several seminal works that highlight the fact that social integration in society, as well as events in the societal environment, such as economic crises and the business cycle, might influence suicide rates, with differences according to gender, age, ethnicity, or other similar factors.1,2

[Correspondence] Social network theory and rising suicide rates in the USA

Thu, 02 May 2019 23:00:08 +0000

Maurizio Pompili (Aug 11, 2018, p 474)1 identified the importance of understanding the emotional experience of suicidal individuals as integral to effective suicide prevention methods. Supporting and extending this concept, we suggest that it is also important for clinicians to assess whether such empathetic understanding exists in an individual's social network. Positive and negative emotions can be transmitted through social connections. For example, Rosenquist and colleagues2 described how depression spread person-to-person across Framingham (MA, USA), from one person to their contacts and to people with up to three degrees of separation (friends' friends' friends).

[Correspondence] Precision public health: pitfalls and promises

Thu, 02 May 2019 23:00:07 +0000

We were delighted that Richard Horton (Oct 27, 2018, p 1504)1 continued the conversation we2 aimed to start about precision public health. However, Horton incompletely characterises our assessment2 of precision public health. He argues that precision public health does not sideline political and social influences on health. In fact, he argues, it does exactly the opposite. Horton cites two studies3,4 to conclude that precision public health “is about using the power of data to improve health and achieve social justice”.

[Obituary] John Mendelsohn

Thu, 02 May 2019 23:00:07 +0000

Renowned cancer researcher who led the University of Texas MD Anderson Cancer Center. Born on Aug 31, 1936, in Cincinnati, OH, USA, he died on Jan 7, 2019, in Houston, TX, USA, of glioblastoma, aged 82 years.

[Perspectives] After the golden age: what is medicine for?

Thu, 02 May 2019 23:00:07 +0000

In the pilot episode of The Sopranos, the central character, capo Tony Soprano mused of the mafia: “Lately, I'm getting the feeling that I came in at the end. The best is over.” I feel a similar regret over the timing of my career in medicine. I qualified in 1983, towards the end of medicine's golden age, which I have, somewhat arbitrarily, defined as lasting from the mid-1930s to the mid-1980s.

[Perspectives] Shitaye Alemu Balcha: committed to rural health care in Ethiopia

Thu, 02 May 2019 23:00:07 +0000

To work on non-communicable diseases (NCDs) in Africa is to work in a branch of medicine that some have not viewed as a priority for the continent. Shitaye Alemu Balcha, Associate Professor in Internal Medicine in the College of Medicine and Health Sciences of the University of Gondar, Ethiopia, would be happy to enlighten them. Shitaye is a specialist in NCDs, diabetes in particular. “My concern over diabetes…came about because of the difficulties facing poor patients who have to walk long distances to the hospital to collect insulin.

[Perspectives] Time to breathe

Thu, 02 May 2019 23:00:07 +0000

Breathing is essential, universal, and largely unconscious. It is endowed with spiritual significance in many cultures: the words for “spirit” and “breath” in many ancient languages share the same roots. Yet somehow the lungs have not acquired the cultural cachet of the heart. In terms of human and financial resources, respiratory diseases are a poor relation to cardiovascular disease, although hundreds of millions of people worldwide have conditions including tuberculosis, pneumonia, and asthma, and chronic obstructive pulmonary disease (COPD) is the world's third largest cause of premature death.

[Perspectives] Dissecting the consultation

Thu, 02 May 2019 23:00:07 +0000

As a medical student, I saw medicine as a science. As a surgeon, it was about skills. As a general practitioner (GP), medicine was a performance. As a patient, I recognise all of these, although what I experience most directly is the performance. Underpinning the science of medicine and the skills of surgery is the consultation. This central act brings two people together in a relationship of care based on trust and integrity. Its aim is to make sense of a problem the patient brings.

[World Report] Northern Ireland deadlock impedes abortion rights progress

Thu, 02 May 2019 23:00:07 +0000

International and local inquiries express concern over the local abortion law's failure to comply with human rights, but devolved government blocks progress. Angel Li reports.

[World Report] Macron's Grand Débat speech falls short for health sector

Thu, 02 May 2019 23:00:07 +0000

At an awaited press conference, the French President failed to offer novel solutions for a strained health sector, on a background of a data privacy scandal. Sharmila Devi reports from Bordeaux.

[World Report] Health under the spotlight as South Africa takes to the polls

Thu, 02 May 2019 23:00:07 +0000

South Africa's leading parties are debating options for health care—but a tendency to reject blame for failures on migration is worrisome. Munyaradzi Makoni reports.

[Comment] Offline: A moral health system demands a moral society

Thu, 02 May 2019 23:00:07 +0000

There is nothing like the personal need for high-quality health care to make one appreciate the importance of universal health coverage as a core institution of a just society. Being away from The Lancet for 6 weeks experiencing the benefits of the UK's National Health Service has certainly given me new energy to use the best available health science as a platform to campaign vigorously for expanding the availability of high-quality health care provided free at the point of delivery. There are few indicators of a civilised society more telling than the presence of a strong health system.

[Comment] Securing a constituency-based approach for youth engagement in NCDs

Thu, 02 May 2019 23:00:07 +0000

Non-communicable diseases (NCDs) accounted for more than 73% of the deaths globally in 2017—a 23% increase from 2008.1 Of these, nearly 40% of deaths are premature2 with three-quarters of them associated with unhealthy behaviours initiated during adolescence and early adulthood.3 These young people are a key target population for NCD interventions. However, with more than 50% of the world's population younger than 30 years,4 youth also represent a key stakeholder group and partner in the fight against NCDs.

[Comment] Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission

Thu, 02 May 2019 23:00:07 +0000

“One must be impressed by the very long road medicine must travel before an understanding of disease is reached, even when its clinical symptomatology is relatively simple.”1 Whether one accepts the Dutch hypothesis advanced by pulmonologists Dick Orie and Henk Sluiter, this idea in the introduction to their 1961 book, Bronchitis,1 still resonates today. Despite many advances in medicine, our understanding of the pathobiological mechanisms that underlie chronic obstructive pulmonary disease (COPD) remains incomplete, the definition of the disease is debated, our diagnostic tests are imprecise, and treatment is inadequate, even as the global burden of the disease continues to increase.

[Comment] Delivering on global health priorities: the WHO Task Force on Nursing and Midwifery

Thu, 02 May 2019 23:00:07 +0000

WHO is entering a new era in its recognition of the vital domains of nursing and midwifery. After the appointment of WHO's Chief Nursing Officer in 2017, the Director-General has endorsed the establishment of the WHO Task Force on Nursing and Midwifery. The taskforce is engaging the global nursing and midwifery community to accelerate collaboration and progress on the health-related Sustainable Development Goals (SDGs).1

[Comment] Health rights are the bridge between law and health

Thu, 02 May 2019 23:00:07 +0000

The Lancet–O'Neill Institute Commission on Global Health and Law1 is a welcome attempt to bridge the divide between the health and legal professions.2 The Commission's report1 shows the ubiquity of law and its contribution to health and health care. It is an exhaustive compilation that positions law as a legal determinant of health. The Commission aims to increase health workforce awareness of law by demonstrating the extent to which they already function within legal parameters. The corollary of such an understanding, and we anticipate the ultimate purpose of the Commission, is to promote engagement of the health profession and the global health community in shaping legal determinants of health.

[Comment] Legal determinants of health: facing global health challenges

Thu, 02 May 2019 23:00:07 +0000

Law is crucial for protecting the health and wellbeing of society. Robust legal systems strive to create a society that is fair. Laws influence every aspect of society and health, from regulating individual lives to stipulating expected behaviours of individuals, states, and corporate entities.

[Comment] Local trends in immunisation coverage across Africa

Thu, 02 May 2019 23:00:07 +0000

Immunisation coverage across Africa has greatly increased over the past few decades, with corresponding reductions in disease mortality and morbidity.1 Future increases in coverage are anticipated to return large health benefits,2 but coverage rates in many countries across the continent are far from national targets, with many rates stagnating or falling.3,4 This incomplete coverage across Africa is still a major contributor to child mortality and morbidity.5 Although national and first-level administrative estimates of routine coverage are assessed annually,4 they conceal heterogeneities in coverage at fine spatial scales, precluding a comprehensive quantitative assessment of local barriers to vaccination and their potential effect on disease burdens.

[Comment] Unite for a Framework Convention for Alcohol Control

Thu, 02 May 2019 23:00:07 +0000

In the 2012 UN Political Declaration, when describing the main contributors to the four most prominent non-communicable diseases, the term harmful use is only used to describe alcohol use. Such a term implies that alcohol use can be safe and beneficial. This assumption could be partly driven by the findings of conventional epidemiology studies indicating moderate drinkers have a lower risk of cardiovascular disease than non-drinkers. Such conclusions have been the topic of debate for several decades because moderate drinkers might have other characteristics that are cardioprotective, rather than alcohol itself (ie, confounding).

[Comment] Placental growth factor testing for suspected pre-eclampsia

Thu, 02 May 2019 23:00:07 +0000

Pre-eclampsia affects between 2% and 8% of pregnancies, and this condition remains a leading cause of maternal and perinatal mortality and morbidity worldwide.1 This syndrome is characterised by new-onset hypertension during pregnancy and it arises from distinct clusters of risk factors.2 Common to each cluster is a specific degree of systemic vascular injury that varies between clusters, which leads to specific end-organ disease. Organ-specific injury via ischaemia and inflammation is the pathway that most commonly leads to fetal growth restriction (FGR) and stillbirth (through placental dysfunction), eclampsia, HELLP syndrome, and renal injury.

[Editorial] Air pollution: a major threat to lung health

Thu, 02 May 2019 23:00:06 +0000

The American Lung Association's State of the Air report, released on April 24, highlights that more than 40% of US citizens—more than 141 million people—live in areas with unhealthy levels of ozone and particulate matter. Deteriorating air quality marks an alarming trend for a country that has reduced emissions of common pollutants since the 1980s. Wildfires and heatwaves in parts of the country most affected by climate change have driven record-breaking levels of pollutants in some of the most densely populated cities.

[Editorial] The emerging voices of youth activists

Thu, 02 May 2019 23:00:06 +0000

We are living in the midst of a wave of worldwide cultural change. Peaceful global activism led by young people is gaining momentum, challenging power structures at every level of society. But, as yet, this potential opportunity has not been seized for health. What more could be done to infuse energy and constructive anger into campaigns for a better health?

[Editorial] The erosion of women's sexual and reproductive rights

Thu, 02 May 2019 23:00:06 +0000

The use of rape as a weapon of war is an unconscionable yet common phenomenon. An annual report from the UN Secretary General last month documents active use of sexual violence in 37 current conflicts, including in the Democratic Republic of the Congo, Myanmar, Somalia, South Sudan, and Syria. Sexual violence in conflict, which is mostly perpetrated against women and girls, is horrific and devastating to individuals, but also intended to destroy whole communities. Over history, it has usually been done with impunity and with little attention by the international community.

Autism Diagnosis Reliable in Young Toddlers

Thu, 02 May 2019 17:00:53 +0000

Diagnoses of autism spectrum disorder are reliable in children as young as 14 months, a study found.
Medscape Medical News

Experimental Agent Shows Promise in Slowing Genetic Form of ALS

Thu, 02 May 2019 17:05:04 +0000

Researchers successfully target elevated levels of a harmful protein, offering hope to people with a genetic form of amyotrophic lateral sclerosis.
Medscape Medical News

Upping Hypertension Meds in Hospital Can Harm Older Patients

Thu, 02 May 2019 15:51:41 +0000

The common practice of intensifying antihypertensive medications for older patients in the hospital for a noncardiac condition should stop, new research shows.
Medscape Medical News

Blood Pressure Drug Disappoints in Slowing Parkinson's

Thu, 02 May 2019 16:01:43 +0000

Despite previous research suggesting the calcium channel blocker isradipine may slow progression of Parkinson's disease, results of a new phase 3 placebo-controlled study suggest this is not the case.
Medscape Medical News

Medicare-for-All Could Have Benefits, Drawbacks, Report Says

Thu, 02 May 2019 14:04:30 +0000

A Congressional Budget Office report on the steps needed to create a single-payer U.S. healthcare system will lend support to both advocates and opponents of this approach.
Medscape Medical News

Reproductive Tract Microbiota Linked to Preterm Birth

Thu, 02 May 2019 14:48:14 +0000

Different bacteria in a woman's reproductive tract can contribute to or protect against early labor. Research continues into potential clinical interventions to make microbiota more supportive.
Medscape Medical News

Doctors Underestimate Obese People's Desire to Lose Weight

Thu, 02 May 2019 14:49:06 +0000

"Healthcare professionals are recognizing obesity as a disease but they believe the patients with obesity are not interested nor motivated to lose weight," when this is not the case, says an expert.
Medscape Medical News

States Weigh Banning a Widely Used Pesticide That EPA Won't

Thu, 02 May 2019 12:52:40 +0000

Lawmakers in several states are trying to ban widely used pesticide chlorpyrifos, but the Environmental Protection Agency is fighting to keep it on the market.
Kaiser Health News

Early PCI Makes Inroads in Elderly With STEMI, Shock

Thu, 02 May 2019 13:21:25 +0000

Trends in both survival and PCI utilization are improving, according to the largest study to examine clinical outcomes for older Americans in this setting.
Medscape Medical News

Ketogenic Diet Safe, Feasible in MS

Thu, 02 May 2019 12:09:41 +0000

A small study shows the diet promotes weight loss and is associated with improved fatigue and depression as well as reduced serologic proinflammatory adipokines in multiple sclerosis.
Medscape Medical News

Clinical Features Outperform Diabetes Subgroups for Outcomes

Thu, 02 May 2019 11:29:15 +0000

Age, weight, and kidney function at diagnosis of diabetes better predict glycemia and renal outcomes, as well as guide choice of therapy, compared with an approach using recently defined "subgroups."
Medscape Medical News

FDA Approves First Vaccine for Dengue, With Restrictions

Thu, 02 May 2019 11:42:44 +0000

Dengvaxia is for the prevention of dengue disease caused by all dengue virus serotypes in people aged 9 to 16 years who have previously had laboratory-confirmed dengue infection and who live in endemic areas.
FDA Approvals

Plant-Based Diets Help Reduce Kidney Disease Risk Long Term

Thu, 02 May 2019 09:57:03 +0000

Sticking to a healthy plant-based or vegetarian diet resulted in favorable kidney disease outcomes in the first study to examine the association between the two.
Medscape Medical News

Seizures Cut in Half After CBD Use in Dravet Syndrome

Thu, 02 May 2019 10:08:17 +0000

Two doses of a purified form of cannabidiol can significantly cut seizure frequency in kids with Dravet syndrome, new research says. Doses above 10 mg/kg/day "should be tailored to individual safety."
Medscape Medical News

New ABIM, ACC MOC Option Offers 10-Year Exam Opt Out

Thu, 02 May 2019 09:02:48 +0000

Changes to maintenance of certification (MOC) process will give cardiologists the option of taking yearly, smaller exams, rather than the high-stakes, 10-year examination now available.
Medscape Medical News

Will Ties to a Catholic Hospital System Tie Doctors' Hands?

Thu, 02 May 2019 09:31:33 +0000

Doctors at the University of California Medical Center are sharply divided over a proposal to join forces with a Catholic-run system that restricts care on the basis of religious doctrine.
Kaiser Health News

Plant-based Diet Linked to Lower Heart Failure Risk

Thu, 02 May 2019 09:39:20 +0000

Several diets are known to lower the risk for cardiovascular events, but few studies have looked specifically at heart failure. New findings suggest a plant-based diet may reduce the risk for incident heart failure.
Medscape Medical News

'Whitish Patch': Increase in Oral Dysplasia in Young Adults

Thu, 02 May 2019 07:16:00 +0000

Dentists report seeing a 'most concerning' increase in asymptomatic young adults who have high-grade precancers and no known risk factors.
Medscape Medical News

Dads' Smoking Linked With Fetal Heart Problems

Wed, 01 May 2019 23:43:02 +0000

Unborn babies are at higher risk of heart defects not just when mothers smoke, but when fathers smoke, too, a new study suggests.
Reuters Health Information

European Commission Approves Risankizumab for Plaque Psoriasis

Wed, 01 May 2019 17:16:26 +0000

In clinical studies, patients with moderate to severe plaque psoriasis saw significantly higher rates of skin clearance with risankizumab compared to current standards of care.
International Approvals

Laser Ablation for Prostate Cancer: Largest Data Set

Wed, 01 May 2019 15:29:39 +0000

Focal laser ablation destroys tumor tissue with precision, but nearly 20% of men needed some form of re-treatment after 1 year.
Medscape Medical News

Poor Oral Hygiene in Kids May Promote Adult Atherosclerosis

Wed, 01 May 2019 14:19:50 +0000

Signs of oral infection in children predicted greater carotid intima-media thickness decades later, complementing known associations between dental health in adults and cardiovascular risk.
Medscape Medical News

Pain Clinics' Docs Needlessly Tested Hundreds of Urine Samples

Wed, 01 May 2019 14:41:51 +0000

A Tennessee-based chain of pain clinics accused of defrauding Medicare and other health insurers billed for hundreds of unnecessary urine drug tests and other dubious health services.
Kaiser Health News

FDA Permits Sale of Tobacco-Heating Alternative to Cigarettes

Wed, 01 May 2019 12:02:25 +0000

The U.S. Food and Drug Administration on Tuesday said it would allow Philip Morris to sell a heated tobacco product called IQOS in the United States, a major victory for the international tobacco giant as it looks to sell more alternatives to traditional cigarettes.
Reuters Health Information

FDA OKs Attain Stability Quad Active-Fixation Left Heart Lead

Wed, 01 May 2019 11:58:35 +0000

The new lead is designed to be fixated precisely in veins of various sizes, including ones not typically amenable to positioning a passive lead.
News Alerts

Improvements Sustained 10 Years After Cervical Disc Replacement

Wed, 01 May 2019 12:12:12 +0000

Longer follow-up of patients with the Mobi-C cervical disc show maintenance of scores for pain, neck disability, and neurologic status, with no worsening of radiographic adjacent segment degeneration.
Medscape Medical News

What's Hot at AAN 2019?

Wed, 01 May 2019 12:25:21 +0000

'Philly Spectacular' is the theme of this year's AAN Annual Meeting, says the event's science committee chair, adding that more than 15,000 attendees are expected at the 'robust and spirited' event.
Medscape Medical News

Weight Loss Surgery Won't Fix Mental Health Problems in Teens

Wed, 01 May 2019 10:23:14 +0000

"We are living in a society that tells us that you will become happy if you lose weight, and everyone is 'tricked' by this," says scientist whose work shows surgery is not a panacea for obesity in teens.
Medscape Medical News

Two Test Positive for HIV After 'Vampire Facial'

Wed, 01 May 2019 10:53:26 +0000

Two customers of a spa in Albuquerque, NM, have been infected with HIV after getting injection-based 'Vampire Facials.'
WebMD Health News

'Inhumane': Prior Authorization Puts Cancer Patients at Risk

Wed, 01 May 2019 10:57:14 +0000

Bureaucratic foot-dragging jeopardizes patient care, leading to treatment de-lays, financial uncertainty, and sometimes, death. 'It is inhumane,' says one radiation oncologist.
Medscape Medical News

Consumer Reports Names Top Sunscreens for 2019

Wed, 01 May 2019 11:00:15 +0000

The rankings include sections for best sprays, sticks, and lip balms, as well as those products considered safe for coral reefs.
WebMD Health News

Have You Ever Ignored Symptoms of an Illness?

Wed, 01 May 2019 11:23:17 +0000

Healthcare professionals are infamous for ignoring their own health problems.
Medscape Reader Polls

Weight Loss Surgery Won't Fix Mental Health Problems in Teens

Wed, 01 May 2019 10:23:14 +0000

'We are living in a society that tells us that you will become happy if you lose weight, and everyone is 'tricked' by this,' says scientist whose work shows surgery is not a panacea for obesity in teens.
Medscape Medical News

Medicare-for-All Gets First Formal Hearing on Capitol Hill

Wed, 01 May 2019 07:40:03 +0000

A House administrative panel held an initial hearing on potential expansion of Medicare. Committees with jurisdiction for the program also are considering changes.
Medscape Medical News

Almost Half of Physicians Say EHRs Have Hurt Quality of Care

Wed, 01 May 2019 07:43:59 +0000

A Medscape poll also indicates that most physicians and nurses/APRNs had no input regarding the choice of EHR systems in their workplace.
Medscape Medical News

More BMI Recording Needed to Meet UK Health Targets

Wed, 01 May 2019 05:12:38 +0000

"We often hear about obesity in the news and think we have all the BMI data we require to plan effective management services. What this data shows us is that’s not the case," Kath Williamson, University of Glasgow.
Medscape News UK

Dutch Fertility Doctor Fathered at Least 49 Children

Tue, 30 Apr 2019 19:19:05 +0000

More are coming forward to see if DNA matches. The doctor, who died in 2017 at age 89, swapped his own sperm for chosen anonymous donors' sperm.
Medscape Medical News

FDA Approves Two-Drug Combo Mavyret for HCV in Adolescents

Tue, 30 Apr 2019 17:05:13 +0000

The FDA approved glecaprevir and pibrentasvir (Mavyret, AbbVie) tablets for the treatment of all six hepatitis C virus (HCV) genotypes in children ages 12 to 17 years.
FDA Approvals

FDA OKs Second Etanercept Biosimilar for Inflammatory Diseases

Tue, 30 Apr 2019 16:31:32 +0000

Etanercept-ykro (Eticovo) is approved across all eligible indications for rheumatoid arthritis, ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, and polyarticular juvenile idiopathic arthritis.
FDA Approvals

Middle-Class Seniors Will Struggle With Housing, Study Shows

Tue, 30 Apr 2019 14:58:30 +0000

About 7.8 million senior citizens may be in the "forgotten middle" by 2029; they will be too well-off for government assistance, but unable to pay for needed housing and healthcare, a study found.
Medscape Medical News

Peanut Oral Immunotherapy May Increase Risk for Anaphylaxis

Tue, 30 Apr 2019 15:34:38 +0000

A new review finds that oral immunotherapy for peanut allergy may result in desensitization but is associated with more anaphylaxis events.
Medscape Medical News

FDA Adds Boxed Warning to Insomnia Drugs

Tue, 30 Apr 2019 15:47:08 +0000

The FDA has added a boxed warning to insomnia drugs, highlighting the risk of serious injury and death caused by sleepwalking, sleep driving, and engaging in other activities while not fully awake.
News Alerts

More Tainted Losartan With Ties to Hetero Labs Recalled

Tue, 30 Apr 2019 14:34:40 +0000

Teva Pharmaceuticals is just the latest company this month to recall losartan products after detecting nitrosamines in the active pharmaceutical ingredient made by Hetero.
News Alerts

FDA Expands Indication for PCSK9 Alirocumab (Praluent)

Tue, 30 Apr 2019 12:49:10 +0000

The decision allows the cholesterol-lowering drug to be prescribed to reduce the risk for major cardiovascular events, including myocardial infarction and stroke.
Medscape Medical News

Personal Encounters With 'God' Confer Mental Health Benefits

Tue, 30 Apr 2019 13:21:40 +0000

Individuals often report lasting, positive changes in their psychological health after spontaneous or psychedelic-induced 'God' experiences, a new study shows.
Medscape Medical News

ВОЗ назвала ситуацию с устойчивостью бактерий к антибиотикам глобальным кризисом

Tue, 30 Apr 2019 19:36:15 +0000

Из-за увеличения устойчивости возбудителей к противомикробным препаратам многие болезни, например туберкулез, все чаще становятся неизлечимыми, а также увеличивается риск проведения медицинских операций. ВОЗ сообщает, что резистентность к антибиотикам, противовирусным, противогрибковым и антипротозойным препаратам в настоящее время является «глобальным кризисом».

Ослабление обоняния связано с увеличение риска смерти на 50 процентов

Tue, 30 Apr 2019 19:42:22 +0000

Слабое обоняние в пожилом возрасте связано с увеличением риска смерти в ближайшие 10 лет на 50 процентов. Однако причина этого феномена пока остается неизвестной, сообщают ученые на страницах Annals of Internal Medicine.

Racism Should Be Treated as an Adverse Childhood Experience

Tue, 30 Apr 2019 11:04:44 +0000

Pediatricians need to be aware of the effects that racial stress can have on the mental and physical health of their patients, experts say.
Medscape Medical News

Hidden in the Epidemic: Opioid-Induced Adrenal Insufficiency

Tue, 30 Apr 2019 11:28:33 +0000

Findings point to the need to screen adrenal function of chronic opioid users.
Medscape Medical News

Cancer Drug Recyclers Chosen for FDA Pilot

Tue, 30 Apr 2019 11:44:48 +0000

The Food and Drug Administration chose two small start-ups, which take unused oral chemotherapies and give them to patients who cannot afford them, to participate in a new pilot project.
Medscape Medical News

Cardiac MRI Improves Culprit Lesion Identification in NSTEMI

Tue, 30 Apr 2019 10:20:30 +0000

Prospective data suggest cardiac MRI picks up culprit lesions frequently missed by invasive angiography, with implications for patients who ultimately undergo revascularization.
Medscape Medical News

Amid Opioid Prescriber Crackdown, Officials Reach Out to Pain Patients

Tue, 30 Apr 2019 10:31:05 +0000

After dozens of health care workers were charged with illegally prescribing opioids in Appalachia, local health agencies are trying to make sure chronic pain patients don't fall through the cracks.
Kaiser Health News

Avoid Food Bloggers When Looking for Nutritional Advice

Tue, 30 Apr 2019 10:33:09 +0000

Social media influencers with weight management blogs are typically unqualified to give nutritional and dietary information and promote inappropriate recipes, UK researchers have found.
Medscape Medical News

Universal Ultrasound in Late Pregnancy May Be Cost-Effective, Potentially Life-Saving in the UK

Tue, 30 Apr 2019 09:26:31 +0000

In the UK, universal late pregnancy ultrasound in nulliparous women could be cost-effective, "virtually eliminate" undiagnosed breech births and reduce related fetal mortality, researchers say.
Reuters Health Information

Parents Bring Newborns to ED for Many Non-Urgent Reasons

Tue, 30 Apr 2019 09:30:25 +0000

One of the hardest things about being a new parent is figuring out when babies are so sick they need to go to the emergency department and when worrisome signs or symptoms might actually be perfectly normal, doctors say.
Reuters Health Information

Regulators Uneven on Safety Warnings on New Drugs

Tue, 30 Apr 2019 07:32:21 +0000

FDA ranks third among health authorities in four English-speaking countries in the frequency of postmarketing drug safety warnings, new data show.
Medscape Medical News

Стресс на работе и недосыпание - опасное сочетание

Tue, 30 Apr 2019 08:36:12 +0000

Стресс на работе и нарушения сна связаны с трехкратным повышением риска смерти от сердечно-сосудистых заболеваний у людей с гипертонией.

US Measles Cases Keep Increasing, Highest in 25 Years, CDC Says

Mon, 29 Apr 2019 17:52:08 +0000

The number of measles cases grew to 704 in 22 states. Washington state declared its outbreak over on April 29, according to the CDC.
Medscape Medical News

Long-term Mortality Risk Linked to Poor Sense of Smell

Mon, 29 Apr 2019 17:06:08 +0000

According to a recent study among older adults, poor sense of smell is linked with higher long-term mortality, with neurodegenerative disease and weight loss only partly driving the association.
Medscape Medical News

AAP Guidance: Adopted Kids Need Thorough Health Exam

Mon, 29 Apr 2019 15:53:51 +0000

A clinical report from the American Academy of Pediatrics stresses that every adopted child needs a thorough health evaluation to identify current and potential health needs.
Medscape Medical News

Biomarker May Be a Diagnostic Test for ME/CFS

Mon, 29 Apr 2019 15:00:31 +0000

The investigational test, based on differential responses to hyperosmotic stress, may serve as a low-cost diagnostic for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Medscape Medical News

Earlier MMR Shot Linked to Faster Decline in Protection

Sun, 28 Apr 2019 13:20:07 +0000

Children vaccinated early during a measles epidemic show a sharper drop-off in antibody concentrations over time than children vaccinated at the recommended time, according to new findings.
Reuters Health Information

News Coverage of Violent Events May Contribute to 'Cycle of Distress'

Sun, 28 Apr 2019 13:24:51 +0000

In the wake of violent events like mass shootings or natural disasters, people who watch the most media coverage of the story are more likely to show post-traumatic stress symptoms months later, a small U.S. study suggests.
Reuters Health Information

Dangerous 'Kissing' Bug Marches North in US

Mon, 29 Apr 2019 13:56:00 +0000

The bugs carry a parasite that causes Chagas disease, which can lead to serious heart and stomach problems.
WebMD Health News

Edwards Recalls Miller and Fogarty Pediatric Cardiac Catheters

Mon, 29 Apr 2019 13:06:39 +0000

The now Class I recall of the company's Miller Balloon Atrioseptostomy Catheter and Fogarty Dilation Atrioseptostomy Catheter follows reports of breakage and balloon detachment during procedures.
News Alerts

Immigration Problems Source of Toxic Stress for Children

Mon, 29 Apr 2019 12:08:24 +0000

Pediatricians need to be aware that government policies can be a source of stress for immigrant children, which can have a negative impact on their health.
Medscape Medical News

The Shaky Role for Niacin in Secondary Prevention

Mon, 29 Apr 2019 11:44:18 +0000

A meta-analysis suggests evidence of clinical benefit is insufficient and not generalizable to contemporary practice, but others say some subgroups may still derive benefit.
Medscape Medical News

Cancer Clinic Quality Initiative Picks Up Speed

Mon, 29 Apr 2019 10:02:55 +0000

The American Society of Clinical Oncology started the Quality Oncology Practice Initiative in 2010. In the past few months, 24 clinical practices achieved certification, an extensive process.
Medscape Medical News

Ведущие платформы для краудфандинга не дадут собирать средства антипрививочникам

Mon, 29 Apr 2019 15:26:35 +0000

Сайт для краудфандинга Indiegogo собирается запретить сбор денег на кампании, связанные с антивакцинаторством и медицинскими концепциями, не имеющими научного подтверждения.

Шанс для больных с неоперабельной опухолью печени

Mon, 29 Apr 2019 15:43:51 +0000

В России впервые применили новый метод лечения рака печени – пациенту с третьей стадией онкозаболевания была успешно проведена радиоционная эмболизация. Эта технология позволяет остановить рост опухоли почти у 90% больных и увеличивает продолжительность жизни в 4-5 раз по сравнению с другими методами лечения.

Cemiplimab and Talazoparib Head Toward Approval in the EU

Mon, 29 Apr 2019 08:16:42 +0000

Both drugs have received a positive opinion from the European Medicine Agency's Committee for Medicinal Products for Human Use, which is the first step in obtaining marketing approval in the European Union.
International Approvals

EMA Panel Recommends Nuceiva for Glabellar Lines

Mon, 29 Apr 2019 06:57:33 +0000

A European Medicines Agency panel recommended marketing authorization for botulinum toxin type A (Nuceiva, Evolus Pharma Ltd) to temporarily correct glabellar lines in patients younger than 65 years.
International Approvals

Cycling to Work Could Cut Obesity-Related Mortality

Mon, 29 Apr 2019 03:59:27 +0000

Simply leaving the car at home for the morning commute and switching to a bike could counteract the increase in mortality and cardiovascular risk seen in obese individuals, suggests a large UK study.
Medscape News UK

Поражения зубов в детстве увеличивают риск атеросклероза во взрослом возрасте

Mon, 29 Apr 2019 09:07:32 +0000

Финское исследование, длившееся в течение 27 лет, показало, что распространенные инфекции ротовой полости у детей – кариес и заболевания пародонта – связаны с повышенным риском развития атеросклероза во взрослом возрасте.

ELLIPSE: Liraglutide Effective for Diabetes in Adolescents

Sun, 28 Apr 2019 17:45:42 +0000

This is a 'practice-changing' study, says the lead author, since 'metformin fails quickly as monotherapy in type 2 diabetes kids and insulin is the only second-line drug approved' for these children.
Medscape Medical News

ELLIPSE: Liraglutide Effective for Diabetes in Adolescents

Sun, 28 Apr 2019 17:45:42 +0000

Homemade Kits With Tourniquets Make Gunshot First Aid More Available

Sun, 28 Apr 2019 13:29:00 +0000

Homemade kits used to train bystanders to step in and stop bleeding after a gunshot wound could save lives, a new report suggests.
Reuters Health Information

Added Convenience of Classifying Nodules With ThyroSeq Test?

Sun, 28 Apr 2019 10:07:58 +0000

Nearly equivalent thyroid nodule classifier test success seen when molecular testing performed on cytology smears, compared with samples collected into preserved solution, although results take longer.
Medscape Medical News

Ученые обращают внимание на рост заболеваемости раком легких среди некурящих

Sun, 28 Apr 2019 11:10:30 +0000

Каждая шестая смерть от рака легких приходится на «никогда не куривших» – тех, кто за свою жизнь выкурил менее 100 сигарет. Согласно исследованию, опубликованному в Journal of the Royal Society of Medicine, рак легких у людей, которые никогда не курили, недостаточно изучен и представляет собой диагностическую проблему, особенно для врачей общей практики.

Common Chemicals May Play a Role in Childhood Obesity

Sat, 27 Apr 2019 10:00:44 +0000

Potentially harmful chemicals found in everyday items might be adding to the country's childhood obesity epidemic, but pediatrician advocacy and consumer action can help turn the tide.
Medscape Medical News

OPTIC Confirms Teprotumumab Benefit in Thyroid Eye Disease

Sat, 27 Apr 2019 10:40:53 +0000

Phase 3 findings support practice-changing use of the IGF-1R inhibitor for treating active thyroid-associated ophthalmopathy.
Medscape Medical News

EU Panel Backs Dolutegravir/Lamivudine Combo Pill for HIV

Fri, 26 Apr 2019 19:18:30 +0000

Dovato contains 50 mg dolutegravir and 300 mg lamivudine and would be the first once-daily, single-pill, completed 2-drug regimen for treatment of HIV in Europe.
International Approvals

EMA Panel Backs Triple Therapy Inhaler for COPD

Fri, 26 Apr 2019 19:47:46 +0000

Temybric Ellipta combines fluticasone furoate, umeclidinium, and vilanterol in a single inhaler and is for maintenance treatment of moderate-to-severe COPD.
International Approvals

EU Panel Recommends Hydroxycarbamide for Sickle Cell Disease

Fri, 26 Apr 2019 18:19:31 +0000

An EMA committee recommended marketing authorization for hydroxycarbamide for the prevention of vaso-occlusive complications of sickle cell disease in patients older than 2 years.
International Approvals

Sleepy Athletes May Face Higher Concussion Risk

Fri, 26 Apr 2019 16:54:35 +0000

College athletes may face a higher risk for sport-related concussions if they have insomnia or even if they're just chronically sleepy, a new study suggests.
Reuters Health Information

Basal Cell Carcinoma Subtype Reporting Varies by Practice, May Put Patients at Risk

Fri, 26 Apr 2019 16:54:41 +0000

Underreporting of basal cell carcinoma (BCC) subtypes occurs in academic, teaching and nonteaching institutions and may place patients at risk for inadequate or inappropriate therapy, researchers say.
Reuters Health Information

'What's Been Lost': A Physician, His Son, and Sri Lanka Attacks

Fri, 26 Apr 2019 17:00:54 +0000

The fifth-grader was on leave from a Washington, DC, school to study abroad for a year. He was one of at least 253 people killed in the Easter attacks.
Medscape Medical News

FDA OKs First Treatment for Pediatric Lupus

Fri, 26 Apr 2019 17:29:07 +0000

Belimumab (Benlysta) intravenous infusion, already approved in adults, may now be used in children aged 5 years and older with active SLE.
FDA Approvals

Review Questions Need for Ophthalmic Screening After Candida Bloodstream Infection

Fri, 26 Apr 2019 16:17:33 +0000

Although candida bloodstream infection is associated with sight-threatening fungal endophthalmitis, routine ophthalmic testing does not seem to improve outcomes and might be harmful, researchers say.
Reuters Health Information

Gunmen Kill Woman Polio Vaccinator in Pakistan - Official

Fri, 26 Apr 2019 16:23:56 +0000

Gunmen shot and killed a female polio vaccinator on Thursday, the fourth this week in the latest surge of violence against efforts to rid the world of the crippling childhood disease, an official said.
Reuters Health Information

Ugandan Mum of Multiple Quadruplets Struggles to Provide for 38 Kids

Fri, 26 Apr 2019 16:30:55 +0000

Mariam Nabatanzi gave birth to twins a year after she was married off at the age of 12. Five more sets of twins followed - along with four sets of triplets and five sets of quadruplets.
Reuters Health Information

Drugmakers Astellas, Amgen to Pay $125 Mln in U.S. Charity Kickback Probe

Fri, 26 Apr 2019 16:23:42 +0000

Two drugmakers will pay nearly $125 million to settle claims they used charities that help cover Medicare patients' out-of-pocket drug costs as a way to pay kickbacks aimed at encouraging the use of their medications, the U.S. Justice Department said on Thursday.
Reuters Health Information

EU Panel Backs Closer Sartan Monitoring, Generic PAH Drug

Fri, 26 Apr 2019 14:46:15 +0000

The European Medicines Agency is taking further steps to prevent future nitrosamine impurities in blood pressure and diabetes meds, and recommended approval for another generic for PAH.
International Approvals

FDA OKs New Topical Treatment Duobrii for Plaque Psoriasis

Fri, 26 Apr 2019 16:25:47 +0000

Duobrii lotion is the first and only topical lotion that combines halobetasol propionate and tazarotene in one formulation.
FDA Approvals

Fitness Linked to Lower Ventricular Arrhythmia Risk Later

Fri, 26 Apr 2019 14:29:21 +0000

The finding fits with abundant evidence that cardiorespiratory fitness, here measured during exercise tests in men followed for decades, protects against cardiovascular events long-term.
Medscape Medical News

EU Panel Backs Closer Sartan Monitoring, Generic PAH Drug

Fri, 26 Apr 2019 14:46:15 +0000

The Committee for Medicinal Products for Human Use is launching a review of how to reduce nitrosamine impurities in blood pressure and diabetes meds, and recommended approval for another generic for PAH.
International Approvals

EMA Panel Backs Long-Lasting Implant for Opioid Dependence

Fri, 26 Apr 2019 13:17:42 +0000

Sixmo consists of four small rods implanted in the upper arm that continuously deliver low levels of buprenorphine for 6 months with promises of boosting adherence to treatment.
News Alerts

Adherence to CV Meds Suffers When Pharmacies Shut Down for Good

Fri, 26 Apr 2019 12:45:49 +0000

Patients fall behind on their statins, beta blockers, and oral anticoagulants when pharmacies close, but there are opportunities for health policy, payers, and pharmacies themselves to help.
Medscape Medical News

Levoketoconazole Offers New Option for Cushing's Syndrome

Fri, 26 Apr 2019 11:27:01 +0000

Phase 3 data suggest the investigational cortisol synthesis inhibitor improves symptoms and may offer a new alternative to current treatments.
Medscape Medical News

More Exercise, Less Screen Time for Under Fives, Says WHO

Fri, 26 Apr 2019 10:17:40 +0000

For children younger than 5 years, physical activity and good quality sleep, as well as spending as little time as possible restrained or in front of screens, is key to their development, says WHO.
Medscape Medical News

Novel CAR T-Cell Approach Reduces Toxicities, Retains Efficacy

Fri, 26 Apr 2019 09:02:09 +0000

The modified molecule for the anti-CD19 CAR T-cell therapy shows signs of reducing the risk for severe cytokine release syndrome while maintaining efficacy.
Medscape Medical News

Nephrologists' Pay Hovers in the Middle of Physician Salaries

Fri, 26 Apr 2019 09:44:19 +0000

Although they are among the most likely to choose medicine again, nephrologists are among the least likely to choose their specialty again.
Medscape Medical News

Zocdoc's New Per-Patient Fee Hits a Nerve With Some Physicians

Fri, 26 Apr 2019 07:13:04 +0000

The new fee system, which is being rolled out nationally, raises concerns that it could be seen as an illegal kickback or that it may incentivize physicians to pad bills to make up for the fee.
Medscape Medical News

ВОЗ выпустила рекомендации по здоровому образу жизни для детей младше пяти лет

Fri, 26 Apr 2019 12:40:42 +0000

Всемирная организация здравоохранения выпустила первое руководство по физической активности, малоподвижному поведению и сну для детей младшего возраста (до 5 лет). Руководство основано на систематическом обзоре научных данных в опубликованных исследованиях, касающихся пользы для здоровья физической активности, сна и ограничения времени, проводимого перед экраном.

[Review] Management of opioid use disorder in the USA: present status and future directions

Thu, 25 Apr 2019 23:00:09 +0000

Opioid use disorder is characterised by the persistent use of opioids despite the adverse consequences of its use. The disorder is associated with a range of mental and general medical comorbid disorders, and with increased mortality. Although genetics are important in opioid use disorder, younger age, male sex, and lower educational attainment level and income, increase the risk of opioid use disorder, as do certain psychiatric disorders (eg, other substance use disorders and mood disorders). The medications for opioid use disorder, which include methadone, buprenorphine, and extended-release naltrexone, significantly improve opioid use disorder outcomes.

[Seminar] Osteoarthritis

Thu, 25 Apr 2019 23:00:09 +0000

Osteoarthritis is a leading cause of disability and source of societal cost in older adults. With an ageing and increasingly obese population, this syndrome is becoming even more prevalent than in previous decades. In recent years, we have gained important insights into the cause and pathogenesis of pain in osteoarthritis. The diagnosis of osteoarthritis is clinically based despite the widespread overuse of imaging methods. Management should be tailored to the presenting individual and focus on core treatments, including self-management and education, exercise, and weight loss as relevant.

[Clinical Picture] Cardiac MRI clinches diagnosis of Libman-Sacks endocarditis

Thu, 25 Apr 2019 23:00:09 +0000

A 28-year-old man presented to our hospital with exertional dyspnoea that had become gradually worse over the previous 3 months. On clinical examination of his heart, the apex was displaced laterally and inferiorly, the first heart sound was muffled, and there was a grade IV–VI apical pan-systolic murmur. 2 days after admission, the patient developed a non-haemorrhagic stroke. A transthoracic echocardiogram showed a dilated left ventricle with global hypokinesia and impaired systolic function: the left ventricular ejection fraction was 33% (video 1).

[Articles] Effectiveness of a brief group psychological intervention for women in a post-conflict setting in Pakistan: a single-blind, cluster, randomised controlled trial

Thu, 25 Apr 2019 23:00:09 +0000

Our group psychological intervention resulted in clinically significant reductions in anxiety and depressive symptoms at 3 months, and might be a feasible and effective option for women with psychological distress in rural post-conflict settings.

[Articles] Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial

Thu, 25 Apr 2019 23:00:09 +0000

In stable patients with obesity hypoventilation syndrome and severe obstructive sleep apnoea, non-invasive ventilation and continuous positive airway pressure have similar long-term effectiveness. Given that continuous positive airway pressure has lower complexity and cost, continuous positive airway pressure might be the preferred first-line positive airway pressure treatment modality until more studies become available.

[Articles] Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study

Thu, 25 Apr 2019 23:00:09 +0000

Our findings support the utility of initial clinical activity and treatment response by 4 weeks to predict week 52 corticosteroid-free remission with mesalazine alone in children who are newly diagnosed with ulcerative colitis. The development of personalised clinical and biological signatures holds the promise of informing ulcerative colitis therapeutic decisions.

[Articles] Efficacy and safety of biosimilar CT-P13 compared with originator infliximab in patients with active Crohn's disease: an international, randomised, double-blind, phase 3 non-inferiority study

Thu, 25 Apr 2019 23:00:09 +0000

This study showed non-inferiority of CT-P13 to infliximab in patients with active Crohn's disease. Biosimilar CT-P13 could be a new option for the treatment of active Crohn's disease.

[Department of Error] Department of Error

Thu, 25 Apr 2019 23:00:09 +0000

Yen LM, Thwaites CL. Tetanus. Lancet 2019; 393: 1657–68—In this Seminar, it was erroneously reported that both UK and USA guidelines recommend low doses of antitoxin (around 500 IU) for tetanus. This recommendation is only included in guidelines from the USA, not from the UK. This correction has been made to the online version as of April 25, 2019.

[Department of Error] Department of Error

Thu, 25 Apr 2019 23:00:09 +0000

Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Lancet 2018; 393: 768–777—In this Article, the footnote to the table should have read “Odds ratios greater than 1 indicate that the drug on that row is more tolerable than the drug on that column. Odds ratios lower than 1 indicate that the drug on that column is more tolerable than the drug on that row.” And in Figure 3b the origin should have been labelled as “1”, not “0”.

[Correspondence] Anna Morandi's successors

Thu, 25 Apr 2019 23:00:09 +0000

Much to our delight, we read Georgina Ferry's Perspective (Aug 4, 2018, p 375)1 about the anatomist Anna Morandi. Choosing an anatomist for the first special theme issue on women in science, medicine, and global health seemed logical because anatomy, especially in its modern form, remains an essential pillar of medicine.1 In 2014, 240 years after Morandi's death, the biography1 connected the two underlying women, a scientist and an artist—two skills this pioneer of anatomy combined to perfection.

[Correspondence] Defamed relations: host community and refugees

Thu, 25 Apr 2019 23:00:09 +0000

Our experience of working in a primary health-care centre (PHCC) in Lebanon dating back to 1956, and serving a wide community of patients who are most in need, including Palestinians, did little to prepare us for the humanitarian consequences of the Syrian civil war. As the influx of Syrian refugees into Lebanon started, several stakeholders began to provide shelter and help to those displaced.1 Our PHCC assumed an important role in the relief efforts by helping to implement several international health and medical aid projects for Syrian refugees.

[Correspondence] The HIV response and global health – Authors' reply

Thu, 25 Apr 2019 23:00:09 +0000

On behalf of the International AIDS Society–Lancet Commission, we appreciate the valuable insights provided by Andy Guise and by Roger Glass and colleagues. Guise echoes the Commission's finding that HIV exceptionalism has been extraordinarily effective, generating an unprecedented, multisectoral, and genuinely global movement that reduced new HIV infections and AIDS-related deaths and made incalculable contributions to the future health and wellbeing of communities and countries across the globe.

[Correspondence] The HIV response and global health

Thu, 25 Apr 2019 23:00:09 +0000

Dramatic gains in global health can be achieved by pursuing a path towards integrated, high-quality care for all, a call to action expressed in the International AIDS Society–Lancet Commission report.1 This assertion highlights that the siloed nature of current health services impedes the ability to meet the aims of the Sustainable Development Goals (SDGs) and motivates the need to leverage the progress in the fight against HIV to address other emerging health threats, especially non-communicable diseases (NCDs).

[Correspondence] The HIV response and global health

Thu, 25 Apr 2019 23:00:09 +0000

The International AIDS Society–Lancet Commission, led by Linda-Gail Bekker and colleagues (July 19, 2018, p 312),1 celebrates HIV exceptionalism while seeking a new era of global health. With the Commission, Makofane and colleagues2 call for a critical engagement with the causes of inequality that shape susceptibility to HIV, with analysis needing to engage with capitalism and oppression. Exceptionalism provides a framework for this analysis and should be retained for an era of global health and the Sustainable Development Goals.

[Correspondence] Complete response after neoadjuvant treatment for rectal cancer – Authors' reply

Thu, 25 Apr 2019 23:00:09 +0000

We thank Eren Esen and colleagues for their comments on our study of long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer.1 They express concern that our results are too optimistic because of selection bias. We acknowledge this limitation in our discussion. However, two recently published meta-analyses,2,3 including studies with strict inclusion criteria, report similar results regarding local regrowth rates and survival, providing support for our results.

[Correspondence] Complete response after neoadjuvant treatment for rectal cancer

Thu, 25 Apr 2019 23:00:09 +0000

We read the Article by Maxime J M van der Valk and colleagues (June 23, 2018, p 2537)1 with great interest. 85% overall survival and 94% disease-specific survival was achieved in a highly selected patient group from the watch-and-wait registry; however, no standard selection criteria were present. The characteristics of the patients, type of data collection, duration of the treatment, specific combination with chemotherapy, and follow-up strategy for those who were enrolled in the watch-and-wait registry appear unclear.

[Correspondence] Transparency of clinical evidence for medical devices in Europe – Authors' reply

Thu, 25 Apr 2019 23:00:09 +0000

We thank Tetsuya Tanimoto and colleagues for their interest in our Health Policy paper.1 We focused on the need for public disclosure of the clinical evidence for new high-risk medical devices, but of course we agree that there are other aspects of transparency that are just as important.

[Correspondence] Transparency of clinical evidence for medical devices in Europe

Thu, 25 Apr 2019 23:00:09 +0000

Alan G Fraser and colleagues (Aug 11, 2018, p 521)1 discuss the new EU Medical Device Regulation,2 which declares the need for adequate information disclosure to enable health-care professionals to make informed decisions. Fraser and colleagues1 emphasise that under the EU law, “there are no grounds for less clinical evidence being available to health-care professionals about the medical devices that they use than is already available for new pharmaceutical products”. We would like to share one more important issue.

[Perspectives] What we need to talk about when we talk about health

Thu, 25 Apr 2019 23:00:08 +0000

We are living in the best of times and the worst of times for the health of populations. Globally, population health worldwide has never been better. Global life expectancy has risen steadily over the past 150 years, mortality rates in all age groups have fallen, and we have eradicated or reduced the impact of many diseases, such as smallpox and polio, that were once scourges of daily life. It seems undeniable that it is much better to be alive today as far as health is concerned than at any other time in history.

[Perspectives] Elisabete Weiderpass: charting a new course for IARC

Thu, 25 Apr 2019 23:00:08 +0000

Before receiving a fellowship to spend a year at the International Agency for Research on Cancer (IARC) in Lyon, France, in 1994, Elisabete Weiderpass was unsure of where life would take her. Observing the scientific and governing council meetings made a lasting impact. “I was fascinated to see people from such diverse backgrounds and nationalities, and with so many different technical skills and interests, working together to make discoveries that would impact cancer worldwide…I knew one day I would like to sit in one of those chairs, taking the decisions and driving the science”, she says.

[Perspectives] How Victorian England inspired Vincent van Gogh and his art

Thu, 25 Apr 2019 23:00:08 +0000

Vincent van Gogh (1853–90) is usually associated with his native Netherlands or with France, the country where he painted many of his most famous works, and much less often with the UK. The latest feature film about him, At Eternity's Gate, directed by the American painter and film-maker Julian Schnabel, with the American actor Willem Dafoe as a compelling Van Gogh, adds to this tradition. It dramatises the last 2 years of the artist's life in France, including the rejection of his art in Paris, his failed attempt to live with Paul Gauguin in Arles, his slicing off his ear, and his confinement in an asylum—sensitively, if not always accurately.

[World Report] US FDA rules manufacturers to stop selling mesh devices

Thu, 25 Apr 2019 23:00:08 +0000

The US Food and Drug Administration has said that there isn't sufficient safety and efficacy evidence to support the device being distributed in the USA. Ed Holt reports.

[World Report] RTS,S malaria vaccine pilots in three African countries

Thu, 25 Apr 2019 23:00:08 +0000

The vaccine is to be rolled out in Ghana, Kenya, and Malawi, 2 years after the announcement of the programme. Paul Adepoju reports.

[World Report] Doctors arrested in US crackdown on illegal opioids

Thu, 25 Apr 2019 23:00:08 +0000

The multiagency operation hit five states and led to the arrest of 60 people. Perpetrators face up to 50 years' prison sentence if found guilty. Susan Jaffe reports.

[World Report] Alemtuzumab to be restricted pending review, says EMA

Thu, 25 Apr 2019 23:00:08 +0000

Reports of stroke in patients having taken alemtuzumab for multiple sclerosis prompt a safety review by the European Medicines Agency. Becky McCall reports.

[Comment] Offline: Japan—rich nation, big questions

Thu, 25 Apr 2019 23:00:08 +0000

Unusual as it might seem in a post-everything world, Japan is welcoming (and pondering the meaning of) a new imperial era. The Reiwa period begins on May 1, 2019, with the accession of Crown Prince Naruhito as the country's 126th Emperor. There is some uncertainty about the meaning of Reiwa, but the official translation is “beautiful harmony”. The end of Emperor Akihito's Heisei period is a useful moment to reflect on Japan's future. Japan is a “great power”—a member of the G7 and G20, and the world's third largest economy.

[Comment] Gambling control: in support of a public health response to gambling

Thu, 25 Apr 2019 23:00:08 +0000

Gambling has been identified as a threat to health,1 but responses, including policy and industry-funded corporate social responsibility initiatives, continue to focus on individual gamblers rather than, as is increasingly accepted for other health threats, challenging the companies that profit from this misery. There is a need to rapidly move away from this individual–level narrative and address the wider corporate determinants of health in relation to gambling. At the same time, there is a need to limit the ability of industry to prevent the implementation of effective measures.

[Comment] Gender mainstreaming within WHO: not without equity and human rights

Thu, 25 Apr 2019 23:00:08 +0000

Addressing gender inequalities through an equity and human rights lens is central to the leave no one behind pledge of the Sustainable Development Goals and is at the heart of WHO's normative responsibility. 1,2

[Comment] Management of psychological distress by non-specialists in conflict-affected areas

Thu, 25 Apr 2019 23:00:08 +0000

In the past decade, there has been a renewed emphasis on global mental health and increased attention on strategies to scale up mental health intervention in low-income and middle-income countries.1 The rationale for this intervention is high unmet need, resource limitations, and barriers to care in such settings. Therefore, focus has been on developing interventions that can be implemented by non-mental health professionals, who are supported through training and supervision. Several counter-arguments to this approach have been made, particularly in relation to the application of a psychiatric and biomedical perspective to problems that have their roots in geopolitical and social contexts.

[Comment] Obesity hypoventilation syndrome: is less really more?

Thu, 25 Apr 2019 23:00:08 +0000

Obesity is a common cause of chronic respiratory failure with a reported prevalence of about 0·5% in the USA.1 When obesity is complicated by hypercapnic respiratory failure, it is termed obesity hypoventilation syndrome, which is defined as obesity, sleep-disordered breathing, and hypercapnic respiratory failure in the absence of another cause of hypoventilation. The nature of sleep-disordered breathing in obesity hypoventilation syndrome varies, although the majority of patients have obstructive sleep apnoea with or without hypoventilation.

[Comment] Personalised therapy for inflammatory bowel disease

Thu, 25 Apr 2019 23:00:08 +0000

Children presenting with inflammatory bowel disease (IBD) typically have a moderate-to-severe disease phenotype, accompanied by frequent complications and challenging management.1 However, substantial differences exist between patients, with some having relatively quiescent disease and others requiring early escalation of therapy or early surgery.2 Robust predictors of disease outcome have the potential to affect disease management, but generation of such predictors is only possible if data are collected rigorously and analysed carefully—a challenge for researchers outside of clinical trials.

[Comment] Infliximab biosimilar CT-P13 in Crohn's disease

Thu, 25 Apr 2019 23:00:08 +0000

The first biosimilar monoclonal antibody to receive marketing authorisation from the European Medicines Agency was the infliximab biosimilar CT-P13, in 2013.1 At the time of registration, equivalence trials for CT-P13 had been performed in ankylosing spondylitis (PLANETAS)2 and rheumatoid arthritis (PLANETRA).3 As a consequence, use of CT-P13 in inflammatory bowel disease (IBD) was approved as an extrapolated indication. Extrapolation is a key component in the regulatory approval of biosimilars.

[Editorial] Mining: protect the rights of local communities

Thu, 25 Apr 2019 23:00:08 +0000

In March, 2016, Sikhosiphi “Bazooka” Rhadebe, who had been protesting against a titanium mine in the Xolobeni region of South Africa, received eight shots to the head in his home. Three years later, the perpetrators have not been identified. Rhadebe's death was in no way an isolated incident, as was reported in a joint report published April 16 by the Centre for Environmental Rights, groundWork, Earthjustice, and Human Rights Watch, which finds that those who dare protest against mining activities in South Africa face harassment, intimidation, or violence.

[Editorial] Paediatric practice in a modern era

Thu, 25 Apr 2019 23:00:08 +0000

Imagine you are a clinician and you have just finished a ward round involving a complex paediatric patient. It is a Thursday afternoon. Watching the television later, you discover the whole case—including your name and personal details—is the lead item on the evening news. Within another 24 h, not only is the issue a matter of international debate, but US President Trump and the Pope are also embroiled in the case.

[Editorial] Measles eradication: a goal within reach, slipping away

Thu, 25 Apr 2019 23:00:08 +0000

Prior to the introduction of the measles, mumps and rubella vaccine (MMR) in 1963, an estimated 3 to 4 million people in the USA contracted measles annually. As of April 22, 626 children in the USA have become infected with the virus so far in 2019. This fact has led to urgent Congressional hearings, understandably alarmed national news coverage, and the introduction of legislation to address the outbreak. Measles was declared eliminated in the USA in 2000, but the resurgence of the disease and its continued prominence globally are causes for great concern.

Scientists Turn Brain Signals Into Speech, May Help People Who Cannot Talk

Thu, 25 Apr 2019 18:31:27 +0000

People robbed of the ability to talk due to a stroke or another medical condition may soon have real hope of regaining a voice thanks to technology that harnesses brain activity to produce synthesized speech, researchers said on Wednesday.
Reuters Health Information

Inhaler Errors Common Among Kids Hospitalized for Asthma

Thu, 25 Apr 2019 18:26:36 +0000

Older children and those using a spacer with a mouthpiece, rather than a mask, were particularly likely to skip a critical step in their inhaler technique.
Medscape Medical News

Hope for Patients With Prolonged Disorders of Consciousness

Thu, 25 Apr 2019 17:10:54 +0000

New therapeutic approaches are providing hope that patients can show improvement and can benefit from various interventions even years after injury, a new review of the field indicates.
Medscape Medical News

Large Shortages in Primary, Specialty Physicians Seen by 2032

Thu, 25 Apr 2019 17:30:21 +0000

The AAMC said it is studying how burnout and the aging physician population may affect the healthcare workforce. More than 40% of the current physician workforce is age 55 or older, the group said.
Medscape Medical News

Drug-Diverting Nurse Blamed for Washington HCV Outbreak

Thu, 25 Apr 2019 14:53:44 +0000

In the era of widespread opioid abuse, narcotic diversion by staff highlights need for enhanced drug storage security and monitoring of drug-dispensing systems at hospitals.
Medscape Medical News

FDA Warns of Stroke, Death With Off-Label Use of Wingspan Stent

Thu, 25 Apr 2019 15:42:15 +0000

Postmarket data show a significantly increased risk of stroke or death when the Wingspan intracranial stent system is used outside the approved indications.
News Alerts

Docs Fall Short in Following Opioid Prescribing Guidance

Thu, 25 Apr 2019 14:27:00 +0000

Recommendations on safer opioid prescribing for chronic pain have not been consistently applied, which could risk patient health, federal health officials say.
Medscape Medical News

New Approaches Targeting the Microbiome in CV Disease

Thu, 25 Apr 2019 14:38:16 +0000

The latest research is focusing on inhibiting or boosting various metabolites of gut bacteria rather than targeting the microbiome itself, a new review reports.
Medscape Medical News

Legacy Pharmaceutical Expands Losartan Recall

Thu, 25 Apr 2019 13:44:17 +0000

The repackaged lot was distributed nationwide and tied to a larger recall of losartan announced just days ago.
News Alerts

Прием антибиотиков в зрелом возрасте увеличивает риск инфаркта и инсульта у женщин

Thu, 25 Apr 2019 19:46:12 +0000

Риск инфаркта и инсульта у женщин старше 60 лет, принимавших антибиотики более двух месяцев, на 32% выше, чем у женщин, не принимавших антибиотики. У женщин среднего возраста аналогичный риск ниже.

Cardiologists' Pay Increases, Vast Majority Would Make Same Career Pick

Thu, 25 Apr 2019 12:12:51 +0000

Cardiologists remain among the top earners in medicine, more than half feel fairly compensated and most would pick medicine and cardiology again, despite the increasing burden of paperwork.
Medscape Medical News

Neurologists' Income Up, Most Happy With Career Choice

Thu, 25 Apr 2019 12:27:02 +0000

Neurologists' average annual income is $267,000, up from $244,000 in 2018, but only half feel they are fairly compensated.
Medscape Medical News

Курить бросить проще, если использовать сразу несколько средств замещения никотина

Thu, 25 Apr 2019 18:11:43 +0000

Ученые обнаружили, что при одновременном использовании никотинового пластыря и никотинзаместитеьной терапии другого типа (например, жевательной резинки или пастилки) повышается вероятность того, что человек успешно бросит курить, чем при использовании средств одного типа.

Hypothyroidism Limits Adaptation to Cold Environments

Thu, 25 Apr 2019 10:09:49 +0000

Therapy seems to relieve the symptoms, and patients with hypothyroidism show significant increases in energy expenditure after being treated to normalize hormone levels.
Medscape Medical News

Endocrinologists Rank at the Bottom in Salary Satisfaction

Thu, 25 Apr 2019 09:04:09 +0000

Their pay increased this year to an average of $236,000, landing the specialty fourth-lowest among physicians, and they tied for the bottom spot in pay satisfaction. Time spent on paperwork is above average.
Medscape Medical News

New CMS Hospital Rule Seeks More Pay for CAR-T, Some Devices

Thu, 25 Apr 2019 09:13:06 +0000

CMS has proposed Medicare changes to its add-on payments for innovative medical products as part of its draft fiscal 2020 hospital inpatient rule.
Medscape Medical News

Rheumatologists See Little Growth in Salary

Thu, 25 Apr 2019 08:44:08 +0000

Average pay increased by $2,000 to $259,000 in this year's Medscape report. Forty percent of physicians in the specialty spend 20 hours or more on paperwork.
Medscape Medical News

Are Hospitalists Losing Their Procedural Acumen?

Thu, 25 Apr 2019 07:15:35 +0000

Authors identify gaps in comfort and experience among hospitalists in performing core bedside procedures and say such deficits nationwide 'constitute a serious threat to hospitalized patients.'
Medscape Medical News

Счастье одного супруга продлевает жизнь другому

Thu, 25 Apr 2019 12:31:33 +0000

Личная удовлетворенность жизнью меньше влияет на продолжительность жизни, чем счастье супруга. Известно, что удовлетворенность жизнью связана с поведением, которое может повлиять на здоровье, диету и физическую активность, а если один партнер пребывает в депрессии, то депрессия грозит и второму партнеру.

Bowing to U.S. Demands, U.N. Waters Down Resolution on Sexual Violence in Conflict

Thu, 25 Apr 2019 00:19:45 +0000

A U.S. threat to veto U.N. Security Council action on sexual violence in conflict was averted on Tuesday after a long-agreed phrase was removed because President Donald Trump's administration sees it as code for abortion, diplomats said.
Reuters Health Information

US Measles Cases Now the Highest Since Eliminated in 2000

Wed, 24 Apr 2019 20:00:59 +0000

The number of confirmed measles cases in the United States is now at 695, in 22 states, according to the CDC.
Medscape Medical News

Some 156 People in 10 States Infected With E. Coli From Ground Beef: CDC

Wed, 24 Apr 2019 17:50:09 +0000

A total of 156 people in 10 states have been infected with E. coli after eating tainted ground beef at home and in restaurants since the beginning of March, the U.S. Centers for Disease Control and Prevention (CDC) said on Tuesday.
Reuters Health Information

Walgreens, Rite Aid to Sell Tobacco Products to Customers Above 21 Years

Wed, 24 Apr 2019 18:13:22 +0000

Drugstore retailers Walgreens Boots Alliance Inc and Rite Aid Corp said on Tuesday they would sell tobacco products to customers who are at least 21 years old, amid a crackdown on teenage tobacco use.
Reuters Health Information

Pesticide Exposure Linked to Worse Outcomes in Diffuse Large B-Cell Lymphoma

Wed, 24 Apr 2019 16:54:25 +0000

Diffuse large B-cell lymphoma (DLBCL) patients exposed to pesticides on the job have worse overall survival (OS) and event-free survival (EFS) and are less likely to respond to treatment, according to new findings.
Reuters Health Information

Low-Carb, High-Fat Breakfast Reduces Hyperglycemia in T2DM

Wed, 24 Apr 2019 17:38:02 +0000

Eating a very-low-carbohydrate, high-fat breakfast (LCBF) helps people with type 2 diabetes (T2DM) avoid postprandial glycemic excursions and reduces their overall exposure to hyperglycemia, new findings show.
Reuters Health Information

Primary Anastomosis With Diverting Loop Ileostomy for Acute Diverticulitis Found Safe

Wed, 24 Apr 2019 17:44:02 +0000

Primary anastomosis with diverting loop ileostomy (PADLI) is a safe alternative to Hartmann's procedure (HP) for emergency management of patients with acute diverticulitis, researchers report.
Reuters Health Information

Intrasaccular Device Effective, Safe for Difficult Aneurysms

Wed, 24 Apr 2019 16:57:55 +0000

The Woven EndoBridge Intrasaccular Therapy device (WEB) proved safe and effective for treating wide-neck bifurcation aneurysms in the prospective, single-arm WEB-IT study.
Medscape Medical News

For Rare, Difficult Cancer, New Drug Is a 'Major Advance'

Wed, 24 Apr 2019 17:01:35 +0000

Tagraxofusp, the first-ever drug for blastic plasmacytoid dendritic-cell neoplasm, is being called a major advance. Data are now published in the New England Journal of Medicine.
Medscape Medical News

In Many States, Pregnancy Invalidates a Woman's DNR

Wed, 24 Apr 2019 15:52:20 +0000

Most states have statutes that invalidate a woman's advance directive if she is pregnant, a U.S. study finds. And because those statutes are often not clearly outlined in the DNR form, women filling out an advance directive most likely would not know that it wouldn't apply if they were pregnant, researchers reported Tuesday online in JAMA.
Reuters Health Information

Therapy by Phone or Web Improves Patient-Reported Outcomes in IBS

Wed, 24 Apr 2019 15:58:32 +0000

Cognitive behavioral therapy (CBT) delivered by phone or online leads to improvements in patient-reported outcomes in irritable bowel syndrome (IBS), according to a clinical trial from the U.K.
Reuters Health Information

Albuterol Before Tonsillectomy Protects Against Respiratory Problems

Wed, 24 Apr 2019 16:03:42 +0000

Preoperative inhaled albuterol can help protect against perioperative respiratory adverse events in young children undergoing anesthesia for tonsillectomy, according to data from the Australian REACT trial.
Reuters Health Information

Plasma Neurofilament Light Predicts Alzheimer Neurodegeneration

Wed, 24 Apr 2019 16:08:13 +0000

Longitudinal plasma neurofilament light (NfL) levels are associated with neurodegeneration in Alzheimer disease, researchers report.
Reuters Health Information

U.S. Brings First Criminal Case Against Major Drug Distributor Over Opioids

Wed, 24 Apr 2019 16:15:19 +0000

The U.S. government on Tuesday filed its first criminal charges against a major drug distributor and company executives over their alleged roles in fueling the nation's opioid epidemic by putting profits ahead of patients' safety.
Reuters Health Information

Teva Scraps Cluster Headache Program

Wed, 24 Apr 2019 15:41:09 +0000

Teva Pharmaceutical Industries Ltd said on Tuesday it would stop developing its migraine drug, Ajovy, for treating cluster headaches.
Reuters Health Information

End-to-Side Nerve Grafting Restores Erectile Function After Prostatectomy

Wed, 24 Apr 2019 15:45:00 +0000

Microsurgical bilateral end-to-side nerve grafts can restore erectile function and improve sexual quality of life in men who have undergone radical prostatectomy, according to Australian researchers.
Reuters Health Information

FDA OKs Wearable Device for In-Home Monitoring of Vital Signs

Wed, 24 Apr 2019 14:48:00 +0000

The Current device, approved for use in hospitals, can now be used by patients with chronic conditions at home to help providers monitor vital signs and to prevent readmission.
FDA Approvals

FDA Approves TransPyloric Shuttle Intragastric Device for Obesity

Wed, 24 Apr 2019 14:06:47 +0000

The endoscopically delivered intragastric device provides another option for patients who are obese but ineligible, or unwilling, to have bariatric surgery, and has advantages over intragastric balloons.
FDA Approvals

How Do Oncologist Salaries Compare With Other Specialties?

Wed, 24 Apr 2019 12:08:24 +0000

Oncologists' salaries in 2018 were in the top half of those reported by all specialties, and about half of those who responded felt that they were being fairly compensated.
Medscape Medical News

Lotus Edge Gets FDA Approval for TAVR in High-risk Patients

Wed, 24 Apr 2019 12:13:37 +0000

This is the first repositionable and fully retrievable transcatheter aortic valve replacement device available in the United States.
FDA Approvals

Psychiatrists Earning Less but Remain Happy at Work

Wed, 24 Apr 2019 12:35:51 +0000

On average, psychiatrists earned $13,000 less this year than last, yet most are satisfied in their career, findings from Medscape's newly released physician compensation report shows.
Medscape Medical News

Недостаток употребления воды связали с лишним весом у детей

Wed, 24 Apr 2019 18:16:27 +0000

Как выяснили исследователи из университета штата Пенсильвания, дети и молодые люди, которые не пьют чистую воду в течение дня, потребляют вдвое больше калорий из сладких напитков по сравнению с теми, кто пьет воду. В долгосрочной перспективе это приводит к набору лишнего веса.

Do You Talk to Your Patients About Advance Care Planning?

Wed, 24 Apr 2019 10:01:42 +0000

A new report found that less than 3% of physicians are using ACP codes for Medicare beneficiaries.
Medscape Reader Polls

SCS with Closed-Loop System Superior to Open-Loop

Wed, 24 Apr 2019 10:43:36 +0000

The first randomized phase 2 trial to evaluate outcomes for spinal cord stimulation finds an advantage for an investigational closed-loop system over open-loop.
Medscape Medical News

Cancers, Infectious Diseases Get Large Portion of New Drugs

Wed, 24 Apr 2019 06:55:37 +0000

A report also shows that nearly half of all drugs launched in 2018 were approved after trials with fewer than 500 participants, as the need grows for niche treatments. Mean development is 13.7 years.
Medscape Medical News

Clinicians' Comfort Levels Low With Life Expectancy Discussions

Wed, 24 Apr 2019 07:00:19 +0000

Fewer than half of physicians and nurses report in a Medscape poll that they frequently have such talks with older patients who have chronic illnesses. Patients also often put off the discussions.
Medscape Medical News

Пластический хирург: как понять, что перед тобой профессионал

Wed, 24 Apr 2019 10:00:39 +0000

Любое хирургическое вмешательство не безопасно, но теоретически количество осложнений после эстетических операций должно быть существенно меньше, ведь пластические хирурги оперируют здоровых людей. Тем не менее, число осложнений после таких вмешательств растет, и специалисты рекомендует гражданам внимательно смотреть, кому они доверяют свои красоту и здоровье.

Ученые подсчитали, насколько кофеин улучшает спортивные результаты

Wed, 24 Apr 2019 09:18:29 +0000

Многие употребляют кофе по утрам перед физическими упражнениями или утренней пробежкой. В этом действительно есть смысл: новый обзор более 300 исследований показал, что кофеин повышает спортивные показатели на 2-16 процентов.

Promising Results in Mice Prompt Human Trial of Novel Lymphoma Vaccine

Wed, 24 Apr 2019 00:13:56 +0000

An in situ vaccine (ISV) combined with immune stimulants and radiotherapy showed efficacy in mice, prompting a phase 1 trial of patients with advanced indolent non-Hodgkin's lymphoma (INHL), researchers say.
Reuters Health Information

Computers Diagnose PTSD by Analyzing Veterans' Speech Patterns

Tue, 23 Apr 2019 18:07:23 +0000

Voice analysis software can help detect post-traumatic stress disorder (PTSD) in veterans based on their speech, a study suggests.
Reuters Health Information

Non-Adherence to Antiplatelet Therapy After PCI Ups Risk of MACE in Anemic Patients

Tue, 23 Apr 2019 17:34:19 +0000

In anemic patients who have undergone percutaneous coronary intervention (PCI), non-adherence to dual antiplatelet therapy (DAPT) - but not physician-recommended discontinuation - is associated with a higher risk of major adverse cardiovascular events (MACE) in the two years following the procedure, researchers say.
Reuters Health Information

Research Needed on Long-Term Osteoporosis Drug Therapies

Tue, 23 Apr 2019 17:26:09 +0000

A variety of drugs are effective for preventing osteoporotic fractures, but there are gaps in the evidence supporting their safety and effectiveness beyond three years, according to a National Institutes of Health Pathways to Prevention Workshop.
Reuters Health Information

Soft Bedding Top Cause of Suffocation Death for Sleeping Babies in US

Tue, 23 Apr 2019 17:18:02 +0000

Most sleep-related suffocation deaths among babies less than one year old happen because infants' airways got blocked by things like pillows, blankets, couch cushions or adult mattresses, a U.S. study suggests.
Reuters Health Information

Lawmaker Under Fire for Questioning Rural Nurses' Work Ethic

Tue, 23 Apr 2019 15:38:13 +0000

Washington State Senator Maureen Walsh's comments that nurses "probably play cards for a considerable amount of the day" sparked backlash on social media. She has apologized.
Medscape Medical News

Expert Consensus Proposes Tiered System for Valvular Heart Disease

Tue, 23 Apr 2019 14:14:45 +0000

A new expert consensus document proposes a two-tiered care delivery system for patients with valvular heart disease, akin to that used for stroke and trauma care.
Medscape Medical News

Mislabeled Fentanyl Patches Spark Nationwide Recall

Tue, 23 Apr 2019 14:37:34 +0000

Two lots of transdermal patches from the Fentanyl Transdermal System for pain management are being voluntarily recalled by the manufacturer because of product mislabeling.
News Alerts

Mental Health Apps Often Share Data Without Users' Knowledge

Tue, 23 Apr 2019 14:37:41 +0000

Many top-ranked apps for depression and smoking cessation share data with third parties without adequately disclosing this information to users.
Medscape Medical News

О чем надо спросить себя, прежде чем решиться на пластическую операцию

Tue, 23 Apr 2019 19:00:58 +0000

Стремительное развитие технологий и повышение доступности пластических операций делает пластическую хирургию все более популярной. Но «красота требует жертв», и прежде, чем решиться на операцию, следует положить на одну чашу весов свое желание улучшить внешность, а на другую – то, чем придется ради этого пожертвовать. А также честно рассказать врачу о проблемах со здоровьем.

Updated Pediatric Blood Pressure Guidelines Catch More Kids at Risk for Heart Disease

Tue, 23 Apr 2019 12:03:29 +0000

Pediatric blood pressure guideline changes issued in 2017 increase the number of children diagnosed with high blood pressure, a new study finds.
Reuters Health Information

Stem Cell Transplant An Effective Tool in Autoimmune Disease

Tue, 23 Apr 2019 11:59:42 +0000

Patients with severe and refractory autoimmune disease such as multiple sclerosis can have marked improvements with hematopoietic stem cell transplant, as long as they are well selected, say experts.
Medscape Medical News

Ulipristal Tied to Improved Quality of Life With Fibroids

Tue, 23 Apr 2019 12:06:52 +0000

Study found ulipristal was linked to significantly improved quality of life and symptom severity in women with symptomatic fibroids. Expert says women should be counseled about rare but serious liver toxicity.
Medscape Medical News

Burning Need to Help Patients With Schizophrenia Quit Smoking

Tue, 23 Apr 2019 12:20:45 +0000

Patients with schizophrenia smoke at a much higher rate than the general population. Experts are highlighting the urgent need for smoking cessation interventions in this population.
Medscape Medical News

Проживание на западной границе часового пояса может иметь негативные последствия для здоровья

Tue, 23 Apr 2019 18:28:51 +0000

Оказалось, люди, живущие в географическом районе часового пояса с более поздним закатом, ложились спать, в среднем, на 19 минут позже. Это означает примерно 115 часов потерянного сна в год. Проблема состоит в том, что обычно невозможно восполнить недостаток сна, поскольку в рамках часового пояса установлено одинаковое время, к которому необходимо приходить на работу и в школу.

Type 1 Diabetes Tied to Increased Risk for Preterm Birth

Tue, 23 Apr 2019 10:51:55 +0000

Pregnant women with type 1 diabetes had an increased risk for preterm birth, which rose with worsening glycemic control. The results highlight the importance of achieving recommended HbA1c targets.
Medscape Medical News

How Much Activity Offsets the Bad From Prolonged Sitting?

Tue, 23 Apr 2019 11:00:15 +0000

Lots of sitting hurts long-term survival, an effect that can be partly and in some cases largely reversed by recommended physical-activity goals. But exchanging standing for sitting likely won't help.
Medscape Medical News

CMS Offers New Risk-Based Payment Methods to PCPs

Tue, 23 Apr 2019 09:18:18 +0000

The government hopes that a quarter of Medicare primary care providers will participate in programs with shared-savings and capitation arrangements. It also has launched program to prepay large organizations.
Medscape Medical News

Personalize Diabetes Eating Plans, ADA Advises

Tue, 23 Apr 2019 09:38:03 +0000

According to a new statement from the American Diabetes Association, there is no one-size-fits-all eating plan for patients with diabetes.
Medscape Medical News

Congress Faces Challenge With Future Medicare Physician Pay

Tue, 23 Apr 2019 08:21:59 +0000

The latest report from Medicare's trustees reiterates a 2026 expected date for the depletion of a key hospital fund, an event that would trigger reduced pay for many services unless Congress acts.
Medscape Medical News

Measles Cases Approaching Highest Level in Almost 2 Decades

Tue, 23 Apr 2019 07:32:01 +0000

This year, the number of measles cases in the United States is expected to be the highest since the disease was eliminated here in 2000, according to the CDC.
Medscape Medical News

Одеяла и сон с родителями ведут к риску случайного удушения маленьких детей во сне

Tue, 23 Apr 2019 11:32:53 +0000

Случайное удушение во сне является одной из распространенных причин смертности маленьких детей, связанных с повреждениями. Ученые утверждают, что его основными причинами являются одеяла и сон в постели с родителями.

Metformin May Stop Weight Regain After Initial Loss

Mon, 22 Apr 2019 17:00:58 +0000

'Those who lost weight initially after 1 year had remarkable maintenance of the weight loss with metformin,' said the senior author of a 15-year observational study.
Medscape Medical News

Older People Feel More Youthful When They Also Feel in Control

Mon, 22 Apr 2019 16:36:29 +0000

Older adults may feel younger than their age on days when they feel most in control of their lives, a small study suggests.
Reuters Health Information

New Genetic Score Might Help Predict Risk of Barrett's Esophagus

Mon, 22 Apr 2019 16:32:46 +0000

A new genetic risk score (GRS) might help predict the risk of Barrett's esophagus independently of most other risk factors, but the results are not conclusive, according to new research.
Reuters Health Information

Sleep Myths May Hinder Good Sleep and Health

Mon, 22 Apr 2019 16:16:05 +0000

Widespread beliefs about sleeping include advice on how much sleep is enough, what quality sleep means and how to achieve it, but when these pronouncements are wrong, they can do more harm than good, researchers argue.
Reuters Health Information

Certain Factors Predict Celiac Disease Risk in Children With Positive Serology but Negative Biopsy

Mon, 22 Apr 2019 16:00:08 +0000

In children with "potential" celiac disease - positive serology but negative biopsy - who are not on gluten-free diets, factors that may help predict risk for eventual villous atrophy include age at diagnosis, gamma delta lymphocytes and HLA haplotype, researchers say.
Reuters Health Information

Medically Tailored Meal Delivery Improves Outcomes, Cuts Costs

Mon, 22 Apr 2019 15:56:39 +0000

Participation in a medically tailored meals program cut inpatient and skilled nursing admissions and lowered care costs for people with chronic illness and food insecurity, new data suggest.
Medscape Medical News

Fraying Health Safety Net Failing to Stop Syphilis in Rural America

Mon, 22 Apr 2019 16:15:01 +0000

Syphilis is spreading into rural counties across the Midwest and West. Communities grappling with budget cuts and crumbling public health infrastructure lack experience in fighting the disease.
Kaiser Health News

Influenza Season Now Longest in a Decade, CDC Reports

Mon, 22 Apr 2019 16:30:33 +0000

Influenza activity is the highest in 10 years, and although activity is subsiding, it is still elevated, possibly because of a second wave of illness with a new predominant virus, according to the CDC.
Medscape Medical News

Budget Limits Major Constraint on Heart-Failure Research

Mon, 22 Apr 2019 14:09:26 +0000

Insufficient funding is generally the most important of limitations on heart-failure research, but enrolling subjects and contract completion are also significant obstacles, according to a survey by the Heart Failure Society of America (HFSA).
Reuters Health Information

Attacks on Hospital in Ebola Zone Kill Cameroonian Doctor

Mon, 22 Apr 2019 13:54:06 +0000

Attacks on a hospital at the epicenter of Democratic Republic of Congo's Ebola outbreak have killed a Cameroonian doctor and injured several others, the local mayor said on Friday.
Reuters Health Information

Кость, исчезнувшая века назад, вернулась и вызывает у нас боль

Mon, 22 Apr 2019 20:54:34 +0000

Фабелла или сесамовидная кость латеральной головки икроножной мышцы когда-то была почти утрачена людьми в ходе эволюции. Ее постепенное возвращение в течение последнего века было сюрпризом для ученых.

Evolocumab Lowers LDL-C in Diabetic Patients on Maximum Statins

Mon, 22 Apr 2019 13:35:03 +0000

In patients with type 2 diabetes and hyperlipidemia or mixed dyslipidemia on a maximally tolerated statin, treatment with evolocumab lowers low-density-lipoprotein cholesterol (LDL-C) and improves levels of other lipids, researchers say.
Reuters Health Information

Catastrophizing May Help Explain Link Between PTSD, Chronic Pain

Mon, 22 Apr 2019 13:39:35 +0000

Pain catastrophizing mediates the relationship between post-traumatic stress disorder (PTSD) symptoms and chronic pain, according to a new study.
Reuters Health Information

Judge Upholds New York City's Mandatory Measles Vaccination Order

Mon, 22 Apr 2019 12:34:42 +0000

A Brooklyn judge on Thursday ruled against a group of parents who challenged New York City's recently imposed mandatory measles vaccination order, rejecting their arguments that the city's public health authority exceeded its authority.
Reuters Health Information

Higher State Minimum Wage Tied to Lower Suicide Rates

Mon, 22 Apr 2019 12:46:10 +0000

Suicide rates grow more slowly in states that increase their minimum wage, according to a U.S. study that suggests this might be one strategy for curbing deaths by suicide.
Reuters Health Information

1-in-5 US Kids Drink No Water During a Given Day

Mon, 22 Apr 2019 11:06:33 +0000

Children and young adults who drank little or no water consume almost twice as many calories from sugar-sweetened beverages as those who drank water, a study found.
Medscape Medical News

FDA Clears First Device for Treating ADHD

Mon, 22 Apr 2019 11:16:25 +0000

The US Food and Drug Administration has granted marketing authorization for the Monarch external trigeminal nerve stimulation system to treat ADHD in patients between the ages of 7 and 12 years.
FDA Approvals

Доверие мошенникам может быть признаком начинающейся деменции

Mon, 22 Apr 2019 17:47:32 +0000

Задолго до того, как проблемы становятся очевидными, люди ощущают едва заметные изменения в мышлении и суждениях. Одним из предупреждающих знаков – предвестников деменции – могут оказаться ошибочные суждения, делающие человека восприимчивым к мошенничеству.

GH/GnRHa Increases Adult Height in Very Short Children: Study

Mon, 22 Apr 2019 09:28:48 +0000

Combined GH/GnRHa therapy may lead to greater adult height in children with idiopathic short stature, including those with early normal puberty onset or those starting GH treatment mid-puberty.
Medscape Medical News

«Косточки» на ступнях: как избавиться и можно ли не допустить

Mon, 22 Apr 2019 08:35:27 +0000

Стопа человека ежедневно выдерживают огромную нагрузку. Каждый ее элемент отвечает за выполнение определенной функции, и, выйдя из строя, может привести к нарушению работы всей конструкции. Возможно ли корректировать разные виды деформации стопы и как не допустить этой проблемы, рассказал руководитель Центра хирургии стопы и голеностопного сустава ГКБ №17 Москвы Армен Петросян.

Obese Sleep Apnea Patients May Live Longer With PAP Therapy

Sat, 20 Apr 2019 13:24:06 +0000

Obese people with sleep apnea may live longer with positive airway pressure (PAP) therapy, a recent study suggests.
Reuters Health Information

IBD Patients Who Switch From Infliximab to Biosimilar See Mixed Results

Fri, 19 Apr 2019 14:57:01 +0000

Patients with inflammatory bowel disease (IBD) can safely switch from infliximab to the biosimilar CT-P13, though they may face a higher risk of clinical relapse, researchers from Spain report.
Reuters Health Information

Global Burden of Kidney Disease High, Inequities in Care Common

Fri, 19 Apr 2019 18:14:44 +0000

By 2030, 14.5 million people around the world will have end-stage kidney disease (ESKD), yet only 5.4 million will be treated due to economic, social and political factors. And more than 2 million people will die each year due to little or no access to hemodialysis or kidney transplantation.
Reuters Health Information

Watch the Birdie: Badminton Players at Risk for Eye Injuries

Fri, 19 Apr 2019 15:51:11 +0000

Badminton players may be at high risk for serious eye injuries, many of which can bring on permanent vision problems or blindness, according to a study of wounds treated at a Beijing hospital.
Reuters Health Information

Many Older U.S. Gun Owners Don't Store Firearms Safely

Fri, 19 Apr 2019 15:51:24 +0000

Roughly one-third of older people in the U.S. may live in households with guns and a new study suggests that many of those firearms are not stored in the safest way: locked and unloaded.
Reuters Health Information

Rapid Initiation of Single-Tablet, Quadruple Anti-HIV Therapy Effective

Fri, 19 Apr 2019 16:05:12 +0000

A high proportion of patients with newly diagnosed HIV-1 infection achieved an undetectable viral load through 48 weeks after starting Symtuza (Janssen) within two weeks of diagnosis, according to new data from the DIAMOND study.
Reuters Health Information

Reminder Bell Improves Incentive Spirometer Use After CABG

Fri, 19 Apr 2019 16:05:23 +0000

Following coronary artery bypass grafting (CABG) surgery, compliance with incentive spirometer use was improved by the SpiroTimer, an add-on use tracking device that sounds a reminder bell, researchers say.
Reuters Health Information

Diabetes Has Lethal Consequences in Asia

Fri, 19 Apr 2019 15:57:30 +0000

Pooled analysis that included over 1 million adults showed substantially increased risk for all-cause and cause-specific death among those with diabetes; Asian-specific management programs are needed.
Medscape Medical News

HHS Awards Funds to 4 States to Cut Opioid OD Deaths by 40%

Fri, 19 Apr 2019 16:18:18 +0000

The money will fund research to test whether hyper-local integrated programs can drastically reduce overdose deaths in those areas within the next 3 years
Medscape Medical News

Собаки помогают людям достаточно двигаться

Fri, 19 Apr 2019 22:30:43 +0000

Ученые обнаружили, что владельцы собак в четыре раза чаще выполняют рекомендации по необходимой физической нагрузке, чем те, у кого собак нет. 64% владельцев собак гуляют со своими питомцами не менее 150 минут в неделю.

Отсутствие завтрака и поздний ужин помогают инфаркту убивать людей

Fri, 19 Apr 2019 22:40:51 +0000

Пропуск завтрака и ужин незадолго до ночного сна приводят к худшим исходам после перенесенного инфаркта миокарда, выяснили бразильские исследователи. Согласно полученным данным, наличие обеих привычек питания в 4-5 раз повышает вероятность смерти, повторного инфаркта или стенокардии в течение 30 дней после выписки из больницы по поводу инфаркта.

Parent-Child Reminiscing Affects Children's Pain Memories

Fri, 19 Apr 2019 14:58:22 +0000

How parents and children reminisce about the child's recent surgery affects the child's pain memory, researchers from Canada report.
Reuters Health Information

New York City Defends Measles Vaccination Order in Court

Fri, 19 Apr 2019 15:27:17 +0000

New York City's Department of Health defended its mandatory measles vaccination order in a state court on Thursday after a group of anonymous Brooklyn parents sued, arguing that the order was unconstitutional.
Reuters Health Information

In Childhood Epilepsy, Scalp Spike Ripples Predict Seizure Risk Better Than Spikes

Fri, 19 Apr 2019 15:27:36 +0000

In children with epilepsy, recorded scalp spike ripples are better than spikes at predicting seizure risk, according to new findings.
Reuters Health Information

U.S. Senate Leader Calls for Raising Minimum Age to Buy Tobacco Products to 21

Fri, 19 Apr 2019 15:37:23 +0000

U.S. Senate Majority leader Mitch McConnell said on Thursday he plans to introduce legislation to raise the minimum age for buying tobacco products, including vaping devices, to 21 from 18 to curb their "epidemic" use among teens.
Reuters Health Information

Pulse Pressure Better Than Systolic BP for Predicting Severe Diabetic Retinopathy

Fri, 19 Apr 2019 15:37:45 +0000

Pulse pressure (PP), the difference between systolic and diastolic blood pressure, is a better predictor of severe diabetic retinopathy than is systolic blood pressure, researchers from Japan report.
Reuters Health Information

Model Predicts ECV Success in Breech Presentation

Fri, 19 Apr 2019 15:39:02 +0000

The decision tree model incorporates body mass index, parity, and the ultrasonographically measured fore-bag as the three predictors of success.
Medscape Medical News

FDA Okays First Generic Naloxone Nasal Spray for Opioid Overdose

Fri, 19 Apr 2019 13:31:30 +0000

The FDA has granted final approval for the first generic naloxone hydrochloride nasal spray for reversing or stopping the effects from an opioid overdose.
FDA Approvals

CVD Risk Similar in Men, Women With Diabetes, but Care Differs

Fri, 19 Apr 2019 14:39:38 +0000

Contrary to previous studies, researchers found the increase in cardiovascular risk is similar in men and women on developing type 2 diabetes, but differences remain in subsequent preventive care.
Medscape Medical News

Tailored Program Might Help Some With Severe Mental Illness Quit Smoking

Fri, 19 Apr 2019 13:23:38 +0000

A smoking-cessation program tailored to people with schizophrenia and bipolar disorder may help some quit, new findings show.
Reuters Health Information

FDA Okays First Generic Naloxone Nasal Spray for Opioid Overdose

Fri, 19 Apr 2019 13:31:30 +0000

The FDA has granted final approval for the first generic naloxone hydrochloride nasal spray for reversing or stopping the effects from an opioid overdose.
News Alerts

Oral Fecal Capsule Promising for Hepatic Encephalopathy

Fri, 19 Apr 2019 12:21:23 +0000

There are few options for patients with recurrent hepatic encephalopathy, but an oral formulation of fecal microbiota could help, new research shows.
Medscape Medical News

Torrent Recalls 104 More Lots of Tainted Losartan Tablets

Fri, 19 Apr 2019 12:35:20 +0000

The blood pressure tablets contain unacceptable levels of a potential carcinogen nitrosamine impurity that has prompted recalls by the company and other globally.
News Alerts

Brain 'Pacemaker' Remodels Neural Networks to Stop Seizures

Fri, 19 Apr 2019 10:40:59 +0000

Closed-loop brain stimulation appears to reduce focal seizures via indirect changes to neural networks over time, rather than through direct, acute suppression of ictal activity, as previously thought.
Medscape Medical News

'Heartbeat Bills' Give State Lawmakers Pause on Anti-Abortion Tactics

Fri, 19 Apr 2019 09:45:16 +0000

Ohio is the latest Republican-led state to pass a ban on abortion once a fetal heartbeat can be detected. But Tennessee last week backed off on a similar bill, fearing costly legal battles. What now?
Kaiser Health News

TMS Boosts Long-term Memory in Older Adults

Fri, 19 Apr 2019 07:06:47 +0000

Transcranial magnetic stimulation (TMS) improves function of the hippocampal-cortical brain networks and improves long-term memory in older adults.
Medscape Medical News

В Сеченовском университете впервые в мире восстановили кости таза с помощью 3D-принтера

Fri, 19 Apr 2019 09:35:30 +0000

Пациентке, потерявшей из-за онкологического заболевания переднюю стенку таза, заменили ее напечатанной на 3D-принтере индивидуальной титановой конструкцией. И через несколько недель женщина сможет полноценно передвигаться. Операция, проведенная междисциплинарной бригадой хирургов Первого МГМУ им. Сеченова уникальна – ранее подобная методика в мировой практике не применялась.

[Seminar] Tetanus

Thu, 18 Apr 2019 23:00:09 +0000

Tetanus is a vaccine-preventable disease that still commonly occurs in many low-income and middle-income countries, although it is rare in high-income countries. The disease is caused by the toxin of the bacterium Clostridium tetani and is characterised by muscle spasms and autonomic nervous system dysfunction. Global vaccination initiatives have had considerable success but they continue to face many challenges. Treatment for tetanus aims to control spasms and reduce cardiovascular instability, and consists of wound debridement, antitoxin, antibiotics, and supportive care.

[Seminar] Tuberculosis

Thu, 18 Apr 2019 23:00:09 +0000

Tuberculosis remains the leading cause of death from an infectious disease among adults worldwide, with more than 10 million people becoming newly sick from tuberculosis each year. Advances in diagnosis, including the use of rapid molecular testing and whole-genome sequencing in both sputum and non-sputum samples, could change this situation. Although little has changed in the treatment of drug-susceptible tuberculosis, data on increased efficacy with new and repurposed drugs have led WHO to recommend all-oral therapy for drug-resistant tuberculosis for the first time ever in 2018.

[Clinical Picture] A kidney changes size: first increasing and then decreasing

Thu, 18 Apr 2019 23:00:09 +0000

A 39-year-old man was admitted to our department with a 1-day history of pain in his left flank and dizziness. His medical history included poorly controlled diabetes mellitus and a stone in the left upper ureter. On admission to the hospital, he appeared to be in septic shock. His temperature was 38·1°C and his blood pressure was 66/35 mm Hg. Laboratory investigations showed a leucocytosis of 16·58 × 109 per L with 93·6% neutrophils. His renal function was abnormal: blood concentrations of creatinine and urea nitrogen were 0·499 mg/dL and 15·4 mmol/L, respectively.

[Articles] The relationships between democratic experience, adult health, and cause-specific mortality in 170 countries between 1980 and 2016: an observational analysis

Thu, 18 Apr 2019 23:00:09 +0000

When enforced by free and fair elections, democracies are more likely than autocracies to lead to health gains for causes of mortality (eg, cardiovascular diseases and transport injuries) that have not been heavily targeted by foreign aid and require health-care delivery infrastructure. International health agencies and donors might increasingly need to consider the implications of regime type in their efforts to maximise health gains, particularly in the context of ageing populations and the growing burden of non-communicable diseases.

[Articles] Three-dimensional visualisation of the fetal heart using prenatal MRI with motion-corrected slice-volume registration: a prospective, single-centre cohort study

Thu, 18 Apr 2019 23:00:09 +0000

Standard fetal MRI with open-source image processing software is a reliable method of generating high-resolution 3D imaging of the fetal vasculature. The 3D volumes produced show good spatial agreement with ultrasound, and significantly improved visualisation and diagnostic quality compared with source 2D MRI data. This freely available combination requires minimal infrastructure, and provides safe, powerful, and highly complementary imaging of the fetal cardiovascular system.

[Articles] Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial

Thu, 18 Apr 2019 23:00:09 +0000

Incidence of angle-closure disease was very low among individuals classified as primary angle closure suspects identified through community-based screening. Laser peripheral iridotomy had a modest, albeit significant, prophylactic effect. In view of the low incidence rate of outcomes that have no immediate threat to vision, the benefit of prophylactic laser peripheral iridotomy is limited; therefore, widespread prophylactic laser peripheral iridotomy for primary angle-closure suspects is not recommended.

[Articles] β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial

Thu, 18 Apr 2019 23:00:09 +0000

Long-term treatment with β blockers could increase decompensation-free survival in patients with compensated cirrhosis and CSPH, mainly by reducing the incidence of ascites.

[Department of Error] Department of Error

Thu, 18 Apr 2019 23:00:09 +0000

Adepoju P. Mali announces far-reaching health reform. Lancet 2019; 393: 1192—In this World Report, it was reported that a reform carried out by Mali will not be rolled out until 2020, but the reform is planned to begin in 2019 through a phased roll-out. The text now reads: “will not become fully effective until 2022 because of the numerous changes needed to ensure smooth roll-out”, and the title of the paragraph now reads: “Not fully rolled out until 2020”. These corrections have been made to the online version as of April 18, 2019.

[Department of Error] Department of Error

Thu, 18 Apr 2019 23:00:09 +0000

Norman JE, Marlow N, Messow C-M, et al, for the OPPTIMUM study group. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 2016; 387: 2106–16—In this Article, in table 2, the upper 95% CI of the unadjusted odds ratio for the primary outcome of neonatal morbidity or death should be 1·07; in table 3, the p value of the treatment effect in the neonatal outcome in women with history of spontaneous preterm birth should be 0·033.

[Department of Error] Department of Error

Thu, 18 Apr 2019 23:00:09 +0000

Hanley DF, Thompson RE, Rosenblum M, et al. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial. Lancet 2019; 393: 1021–32—In the webappendix of this Article, Colin P Derdeyn's name was spelled incorrectly. This correction has been made to the online version as of April 18, 2019.

[Department of Error] Department of Error

Thu, 18 Apr 2019 23:00:09 +0000

Fraser B. Providing care for trans women with HIV/AIDS in Peru. Lancet 2019; 393: 1399–400—In this World Report, it was reported that the 6-month pilot project aims to reach 200 trans women, when this project aims to reach 100 women. Likewise, it was reported that since the opening of the ward, more than 70 patients have been enrolled, when only 64 patients have been enrolled to date. These corrections have been made to the online version as of April 5, 2019.

[Department of Error] Department of Error

Thu, 18 Apr 2019 23:00:09 +0000

Mente A, O'Donnell MJ, Yusuf S. Urinary sodium excretion measures and health outcomes–Authors' reply. Lancet 2019; 393: 1295–96—In this Correspondence, the name of the author Salim Yusuf was listed incorrectly. This correction has been made to the online version as of April 8, 2019.

[Correspondence] Orphan drugs – Authors' reply

Thu, 18 Apr 2019 23:00:09 +0000

We agree with Francesca Cainelli and Sandro Vento that patients with orphan diseases, regardless of location, ought to receive the best treatment available. We share their appeal on behalf of low-income and middle-income countries for access to orphan drugs.

[Correspondence] Orphan drugs

Thu, 18 Apr 2019 23:00:09 +0000

Luzzatto and colleagues1 give three recommendations for pricing orphan drugs. We will focus on the first recommendation (European price negotiation) and on the first part of the second (cost-based pricing).

[Correspondence] Orphan drugs

Thu, 18 Apr 2019 23:00:09 +0000

The Viewpoint by Luzzatto and colleagues1 on drug pricing addresses a very crucial issue because an increasing number of orphan drugs have been marketed in the past decade, and genetic treatments costing more than €300 000 are being made available. Among the determinants of drug pricing reported in the Viewpoint,1 benefit to the patient is the main factor that is typically examined in cost-effectiveness analyses; disease-specific factors are already recognised to influence drug prices because an inverse association exists between treatment cost and disease prevalence.

[Correspondence] Orphan drugs

Thu, 18 Apr 2019 23:00:08 +0000

Lucio Luzzatto and colleagues1 (Sept 1, 2018, p 791) have called for collaboration from EU member states on negotiation of orphan drug prices to take advantage of the fact that with 500 million inhabitants, the EU is the largest customer for any new drug. Low-income and middle-income countries (LMICs), with more than 6 billion inhabitants and 360–480 million patients with rare diseases,2 are in need of orphan drugs and should join forces in this area.

[Correspondence] Functional capacity and preoperative risk evaluation – Authors' reply

Thu, 18 Apr 2019 23:00:08 +0000

We thank the correspondents for their interest in our study.1

[Correspondence] Functional capacity and preoperative risk evaluation

Thu, 18 Apr 2019 23:00:08 +0000

We commend Duminda Wijeysundera and colleagues1 for testing the prognostic value conferred by assessment of subjective functional capacity in non-cardiac surgery and read the results with interest. We raise two issues with the published data.

[Correspondence] Functional capacity and preoperative risk evaluation

Thu, 18 Apr 2019 23:00:08 +0000

Duminda Wijeysundera and colleagues' prospective cohort study1 challenges concepts of preoperative risk assessment, showing that neither subjective assessments of fitness nor exercise testing were correlated with important cardiopulmonary outcomes. Instead, the structured Duke Activity Status Index (DASI) questionnaire and the predictive assessment of complications through measuring serum concentrations of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) were better correlated with the outcomes.

[Correspondence] Functional capacity and preoperative risk evaluation

Thu, 18 Apr 2019 23:00:08 +0000

I wish to draw attention to two methodological issues that might affect the interpretation of findings in Duminda Wijeysundera and colleagues' Measurement of Exercise Tolerance before Surgery (METS) study (June 30, 2018, p 2631).1

[Correspondence] Awareness of the link between obesity and cancer in UK school curricula

Thu, 18 Apr 2019 23:00:08 +0000

In 2016, a panel of international experts, under the sponsorship of the International Agency for Research in Cancer, concluded that there was sufficient evidence for causal links between body fatness, commonly approximated as body-mass index of 25 kg/m2 or more and increased risk of incidence of 13 cancer types.1 In parallel, Arnold and colleagues2 estimated that elevated body-mass index is responsible for 3·2–7·8% of the burden of new cancers in countries with a very high Human Development Index, making obesity the second commonest cause of cancer after smoking.

[Perspectives] Alzheimer's disease

Thu, 18 Apr 2019 23:00:08 +0000

In his genre-defining Encyclopédie (1765), the French philosopher Denis Diderot defined dementia as “a disease consisting in a paralysis of the spirit characterised by abolition of the reasoning faculty“. For Diderot's generation, dementia (from the Latin demens, “without mind“) was a new frame for an old and diverse set of labels—imbecility, fatuitas, dotage—denoting a progressive and irreversible decline in what we'd now call cognitive and social functioning, typically associated with old age.

[Perspectives] Climate Armageddon

Thu, 18 Apr 2019 23:00:08 +0000

David Wallace-Wells opens his book, The Uninhabitable Earth: Life After Warming, with “It is worse, much worse, than you think.” And within the first 36 pages, the American writer races through evidence of damage already caused by climate change and forecasts humanity's future, peppering sentences with words like annihilation, Armageddon, extinction, and “existential crisis”. There are no safe zones of optimism or passages of hope in Wallace-Wells' book, even in his closing chapter where he avers “The emergent portrait of suffering is, I hope, horrifying.

[World Report] Concerns raised about NHS gender identity service

Thu, 18 Apr 2019 23:00:08 +0000

The Tavistock and Portman NHS Foundation Trust service draws controversy for prescribing hormone blockers to adolescents, others support the approach. Talha Burki reports.

[World Report] DR Congo Ebola outbreak not given PHEIC designation

Thu, 18 Apr 2019 23:00:08 +0000

UN committee decided that the outbreak does not fit the criteria for Public Health Emergency of International Concern, as outbreak grows at worrying rate. Andrew Green reports.

[World Report] Cyclone Idai: 1 month later, devastation persists

Thu, 18 Apr 2019 23:00:08 +0000

Cyclone Idai was one of the most deadliest storms in the southern hemisphere. Funding is now dwindling, at a time where response is still needed. Sharmila Devi reports.

[World Report] Liberia post Ebola: ready for another outbreak?

Thu, 18 Apr 2019 23:00:08 +0000

Years after the west Africa Ebola virus epidemic, Liberia's health system still carries the burden of the deadly outbreak. Laura Salm-Reifferscheidt reports from Gbarnga, Liberia.

[Comment] Offline: The case for compromise

Thu, 18 Apr 2019 23:00:08 +0000

Surrender. Betrayal. Hypocrisy. Suicide. To be sure, words may only be words. But they do hold meaning. They can hurt. And they certainly suggest something about the health of our societies. By which measure, we could reasonably conclude that the UK is struggling through a grave illness. Brexit has inflicted wounds that are proving hard to heal. It has given permission for a style of public dialogue that is angry, coarse, and increasingly xenophobic. Brexit has sharpened rather than smoothed disagreement.

[Comment] Opioid analgesics pass the acid test

Thu, 18 Apr 2019 23:00:08 +0000

Understanding of the neurobiology of pain continues to increase at a remarkable pace, raising optimism for improvements in pain therapy. Physicians can choose from multiple classes of medications to treat acute or chronic pain that can often be highly effective. Many patients, however, do not have their pain well controlled with available drugs, and these drugs often have severe side-effects that can ultimately diminish quality of life and potentially result in serious harm.1 Hence, the need for new medicines for treatment of pain remains very high.

[Comment] Reporting of artificial intelligence prediction models

Thu, 18 Apr 2019 23:00:08 +0000

Data-driven technologies that form the basis of the digital health-care revolution provide potentially important opportunities to deliver improvements in individual care and to advance innovation in medical research. Digital health technologies include mobile devices and health apps (m-health), e-health technology, and intelligent monitoring. Behind the digital health revolution are also methodological advancements using artificial intelligence and machine learning techniques. Artificial intelligence, which encompasses machine learning, is the scientific discipline that uses computer algorithms to learn from data, to help identify patterns in data, and make predictions.

[Comment] Good news for democracy

Thu, 18 Apr 2019 23:00:08 +0000

Do we really need democracy? Clashes between populist political movements and liberal institutions have raised urgent questions about how human beings should be governed. According to an Article by Thomas J Bollyky and colleagues1 in The Lancet, democracy is good for public health. Using cause-specific mortality and HIV-free life expectancy estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016, and information on regime type from the Varieties of Democracy (V-Dem) project, Bollyky and colleagues analysed the association between democratisation and population health in 170 countries between 1980 and 2016.

[Comment] Fetal MRI and prenatal diagnosis of congenital heart defects

Thu, 18 Apr 2019 23:00:08 +0000

Congenital anomalies are among the leading causes of infant mortality in developed countries.1 Mortality associated with congenital heart defects is decreasing; however, it remains unacceptably high.2 The conventional approach for prenatal diagnosis of congenital heart defects is two-dimensional (2D) fetal echocardiography. Using this approach, one group3 reported a significant increase in the detection of congenital heart defects (from 35·8% to 59·7%) after the introduction of a national screening programme.

[Comment] Prophylactic laser iridotomy in primary angle-closure suspects

Thu, 18 Apr 2019 23:00:08 +0000

Primary angle-closure suspects are individuals with 180° or more contact between the iris and trabecular meshwork, normal intraocular pressure, no evidence of peripheral anterior synechiae (iris adhering to the trabecular meshwork), and a healthy optic nerve. These individuals might develop peripheral anterior synechiae and increased intraocular pressure that damages their optic nerve, a condition known as primary angle-closure glaucoma. Although less common than primary open-angle glaucoma, primary angle-closure glaucoma is more visually destructive.

[Comment] Prevention of decompensation in cirrhosis: a new youth for β blockers

Thu, 18 Apr 2019 23:00:08 +0000

The natural history of cirrhosis can be described as a continuum from a compensated phase to decompensation and liver failure, marked by the development of ascites, overt hepatic encephalopathy, or variceal haemorrhage, occurring at a rate of 5–7% per year. This decompensation results in an increased mortality, and a median survival of 2 years versus 12 years in the compensated phase.1 Hepatic fibrosis and the development of portal hypertension are the major pathophysiological processes of this clinical course.

[Editorial] Universal health care in 21st century Americas

Thu, 18 Apr 2019 23:00:07 +0000

Despite considerable progress, the Pan American Health Organization (PAHO) estimates that 30% of the population of the Americas still do not have access to the health care they need because of multifaceted barriers. On April 9, leaders, including Mexico's President Andrés Manuel López Obrador, PAHO director Carissa Etienne, and UN High Commissioner for Human Rights Michelle Bachelet, gathered with academics, activists, and representatives of social movements in Mexico City to hear the report of the Commission on Universal Health in the 21st Century.

[Editorial] Assessing researchers with a focus on research integrity

Thu, 18 Apr 2019 23:00:07 +0000

More than 500 participants will gather in Hong Kong on June 2–5 for the sixth World Conference on Research Integrity (WCRI). One of the ambitions of the WCRIs is to advance research integrity globally by setting standards and agreeing on principles of organising and conducting research. The Singapore Statement, an outcome of the second WCRI in 2010, highlighted four principles and 14 professional responsibilities for researchers and others involved in the research enterprise. The Montreal Statement, developed as part of the third WCRI in 2013, focused on specific challenges for research collaborations.

[Editorial] The doctors' predicament: China's health-care growing pains

Thu, 18 Apr 2019 23:00:07 +0000

The Chinese characters for doctor also refer to scholar-bureaucrats, which was the highest aspiration for intellectuals in ancient China. Doctors were then respected as much as Confucian elites who were supposed to have high moral standards and be well educated, altruistic, and dedicated to serving the country. However, in modern China, medicine is no longer seen as a noble or an attractive profession. Last week, four officials were removed from their posts on the basis of their negligence in reviewing and approving an anti-gang brochure in which doctors were portrayed as gangs and listed as first among the top ten gang categories in China.

Yale Study Revives Cellular Activity in Pig Brains Hours After Death

Thu, 18 Apr 2019 17:57:04 +0000

Yale University scientists have succeeded in restoring basic cellular activity in pigs' brains hours after their deaths in a finding that may one day lead to advances in treating human stroke and brain injuries, researchers reported on Wednesday.
Reuters Health Information

Prolonged Lung Cancer Screening Boosts Mortality Benefit

Thu, 18 Apr 2019 17:28:57 +0000

New data show that CT screening of individuals beyond 5 years can significantly increase survival benefits.
Medscape Medical News

Washington University Med School Latest to Offer Free Tuition

Thu, 18 Apr 2019 17:34:13 +0000

The St. Louis school becomes the seventh in the nation to give full or partial tuition relief to medical students.
Medscape Medical News

MR Enterography Best Identifies Fibrotic Vs Inflammatory Strictures in Crohn's Disease

Thu, 18 Apr 2019 15:00:33 +0000

Conventional imaging techniques accurately detect strictures in patients with Crohn's disease, but magnetic resonance enterography (MRE) best differentiates fibrotic from inflammatory components, researchers say.
Reuters Health Information

France to Ban Titanium Dioxide Whitener in Food From 2020

Thu, 18 Apr 2019 15:08:30 +0000

France will ban the use of titanium dioxide as a food additive from 2020 after the country's health and safety agency said there was not enough evidence to guarantee the safety of the substance.
Reuters Health Information

Doping-Targeted Tests Having an Impact in E-Sports, Says Verroken

Thu, 18 Apr 2019 15:14:05 +0000

Targeted testing of e-sports competitors is leading to a rethink about drug cheating in online gaming and which stimulants are more widespread, according to anti-doping expert Michele Verroken.
Reuters Health Information

Treatment Switch for Hep B Patients With Renal, Bone Risk

Thu, 18 Apr 2019 14:59:15 +0000

A change to a different form of tenofovir might lower the risk for adverse bone and renal effects, new research shows, but concerns about other risks are emerging.
Medscape Medical News

Genetic Crosstalk in Cancer Therapy-Induced Cardiomyopathy

Thu, 18 Apr 2019 15:07:02 +0000

A genetic study links cancer-therapy-induced and dilated cardiomyopathies and signals how identification of genetic risk factors may help change management of those at risk.
Medscape Medical News

Closed-Loop Insulin Delivery May Improve Glycemic Control in Patients on Nutritional Support

Thu, 18 Apr 2019 14:46:11 +0000

Closed-loop insulin delivery appears to improve glycemic control in hospital patients receiving nutritional support, researchers report.
Reuters Health Information

MRI Identifies Rectal-Cancer Patients Suitable for Primary Surgery

Thu, 18 Apr 2019 14:17:28 +0000

MRI criteria can be used to identify "good prognosis" rectal-cancer patients for primary surgery (without chemoradiotherapy first), according to results from the QuickSilver clinical trial.
Reuters Health Information

Multiple Hep B Targets in Development for New Treatments

Thu, 18 Apr 2019 13:48:59 +0000

Hepatitis B is a complex, 'clever' virus so several simultaneous approaches might be needed to eliminate it, experts say.
Medscape Medical News

3D Printer Makes Swaths of Cardiac Tissue and a Tiny 'Heart'

Thu, 18 Apr 2019 13:52:43 +0000

Heart facsimiles up to 2 cm across were printed, along with squares of tissue that could potentially patch up damaged myocardium, from 'inks' containing cultured myocytes and endothelial cells.
Medscape Medical News

One in Five MS Patients Misdiagnosed

Thu, 18 Apr 2019 14:40:56 +0000

Multiple sclerosis misdiagnosis is associated with considerable patient risk and immense healthcare cost through the inappropriate prescribing of drug treatments, authors of a new study say.
Medscape Medical News

Ученые рассказали, как острый стресс "бьет" по сердцу и сосудам

Thu, 18 Apr 2019 20:48:25 +0000

У людей, переживающих последствия острого стресса (например, посттравматическое стрессовое расстройство), болезни сердечно-сосудистой системы развиваются на 37 процентов чаще.

Novel Antiplatelet Agent May Not Increase Bleeding Risk

Thu, 18 Apr 2019 13:19:10 +0000

Initial clinical results suggest that the new agent may be suitable for use with thrombolysis in acute ischemic stroke.
Medscape Medical News

Neurosurgeons Are Working Harder, for Less: Here's Proof

Thu, 18 Apr 2019 11:49:50 +0000

A new study shows Medicare compensation for the 20 most commonly performed neurosurgery procedures fell by more than 25% between 2000 and 2018.
Medscape Medical News

Triple Therapy May Lengthen Survival in Biliary Tract Cancers

Thu, 18 Apr 2019 11:00:32 +0000

Phase 2 findings suggest nab-paclitaxel plus gemcitabine-cisplatin may prolong survival in advanced biliary tract cancers. However, experts urge caution until a phase 3 trial is completed.
Medscape Medical News

Бекон и ростбиф увеличивают риск рака кишечника на 20 процентов

Thu, 18 Apr 2019 17:50:47 +0000

Умеренное количество красного и переработанного мяса в рационе, допускаемое нормативами ВОЗ, увеличивает вероятность развития рака кишечника, согласно крупнейшему исследованию.

Slowed Processing of Facial Emotions May Predict Psychosis

Thu, 18 Apr 2019 10:27:34 +0000

Slow processing and identification of facial emotions may be a reliable predictor of conversion to schizophrenia in high-risk youth with prodromal psychotic symptoms, new research shows.
Medscape Medical News

Reference Values Found for Osteoporosis Screening With CTs

Thu, 18 Apr 2019 08:40:23 +0000

A single center study has identified reference values for opportunistic screening for osteoporosis using CT scans done for other reasons.
Medscape Medical News

Телемедицина для пациентов

Thu, 18 Apr 2019 10:35:57 +0000

Современная медицина ушла далеко вперед, но ее достижения доступны далеко не каждому. Получить своевременное лечение мешает неповоротливость системы здравоохранения, перегруженность и нехватка врачей, да и сама география страны. Возможность хотя бы частично снять проблемы с маршрутизацией, сопровождением и мониторингом состояния пациентов может дать развитие телемедицины.

St. Jude Doctors Claim Cure for 'Bubble Boy' Disease

Wed, 17 Apr 2019 18:20:22 +0000

Relying on the trickery used by the AIDS virus to infect people, doctors at two medical centers say they have cured 10 infants of so-called bubble boy disease, a genetic defect that leaves children, typically boys, without an immune system.
Reuters Health Information

Child Abuse, Recurrent Depression Linked to Similar Changes in Brain

Wed, 17 Apr 2019 17:45:08 +0000

Abuse during childhood may cause physical changes to the human brain that in turn may render adults more vulnerable to depression, research suggests.
Reuters Health Information

New Antibody May Suppress HIV for Up To 16 Weeks Without ART

Wed, 17 Apr 2019 17:05:46 +0000

A novel antibody monotherapy may maintain human immunodeficiency virus (HIV) suppression for up to 16 weeks, newly published data suggest.
Medscape Medical News

Dozens of Doctors in 7 States Charged in Opioid Fraud Bust

Wed, 17 Apr 2019 17:18:55 +0000

Dozens of medical professionals in Appalachia, a region hard-hit by the U.S. opioid crisis, have been charged with writing hundreds of thousands of illegal prescriptions and committing healthcare fraud, federal prosecutors said on Wednesday.
Reuters Health Information

Age-Appropriate CPT Improves Abuse-Related PTSD in Young People

Wed, 17 Apr 2019 16:17:58 +0000

For young people with abuse-related posttraumatic stress disorder (PTSD), developmentally adapted cognitive processing therapy (D-CPT) can be an effective treatment, researchers in Germany say.
Reuters Health Information

In Some States, Sexting Could Land Teens in Jail for a Long Time

Wed, 17 Apr 2019 16:23:01 +0000

Sexting - the texting of sexual images - is increasingly common among teens, but in nearly half the U.S. the practice may hold an unexpected danger: in 23 states, sexting between teens is considered child pornography, which could potentially result in a 20-year prison term and mandatory registration as a sex offender, a new report warns.
Reuters Health Information

Not Eating Good Food Worse Than Eating Bad Food

Wed, 17 Apr 2019 15:55:12 +0000

One in five deaths were tied to poor diets, researchers found; global diets need rebalancing to include more whole grains, milk, nuts, and seeds, experts say.
Medscape Medical News

Ученые развеяли мифы о сне: храпеть опасно, пить вредно, недосыпание губит наверняка

Wed, 17 Apr 2019 22:00:39 +0000

Считается, что достаточно спать пять или даже меньше часов в сутки, что храп безвреден и что выпивка помогает заснуть. По сути, все это – самые распространенные мифы о сне, которые не только формируют вредные привычки, но и могут представлять серьезную угрозу для здоровья. В новом исследовании, опубликованном онлайн в Sleep Health, ученые развенчивают мифы, ставящие под угрозу

Riluzole Does Not Improve Function After Degenerative Disc Surgery

Wed, 17 Apr 2019 14:54:45 +0000

A 6-week course of riluzole did not have a significant effect on the primary outcome of change in function at 6 months beyond surgical decompression, but was associated with less neck pain.
Medscape Medical News

Bariatric Embolization a Future Treatment for Severe Obesity?

Wed, 17 Apr 2019 15:42:18 +0000

The pilot study 'is a great step forward' to establish feasibility, safety, and efficacy of a weight-loss procedure designed to suppress appetite, but will not replace bariatric surgery.
Medscape Medical News

Частоту пульса связали с риском смерти и болезней сердца

Wed, 17 Apr 2019 21:44:50 +0000

Ученые обнаружили у мужчин среднего возраста связь между пульсом, болезнями сердца и риском ранней смерти. Кроме того, у мужчин, пульс которых не менялся с возрастом, реже развивались сердечно-сосудистые заболевания.

Fingerprick PSA Test Has In-Office Results in 12 Minutes

Wed, 17 Apr 2019 14:27:57 +0000

Getting the results of a prostate-specific antigen (PSA) test typically takes days or even weeks, but a new test gives point-of-care results in minutes.
Medscape Medical News

Risky AEDs Still Prescribed to Women of Childbearing Age

Wed, 17 Apr 2019 14:44:53 +0000

Despite warnings that use of certain antiepileptic drugs (AEDs) during pregnancy carry significant risks for poor outcomes in children, the drugs are still being used at concerning levels.
Medscape Medical News

High Cortisol in Hair Indicates Child Trauma, Poor Cognition

Wed, 17 Apr 2019 11:53:15 +0000

Elevated levels of cortisol in the hair of adult patients with schizophrenia or bipolar disorder indicate a history of childhood trauma and poorer cognitive performance, new research suggests.
Medscape Medical News

Can Students Bribe Their Way Into Medical School?

Wed, 17 Apr 2019 11:59:12 +0000

The recent college admissions scandal raises questions about medical school admissions.
Medscape Reader Polls

Acetaminophen May Blunt Empathy

Wed, 17 Apr 2019 10:56:43 +0000

Previous research suggests acetaminophen may blunt empathy for others undergoing negative experiences. A new study suggests it may also affect empathy for others who are having positive experiences.
Medscape Medical News

AFib Patients Often Misjudge Stroke Risk vs OAC Bleeding Risk

Wed, 17 Apr 2019 11:03:47 +0000

But is that okay? Patients may decide to take oral anticoagulants 'without knowing the truth' about the size of their benefits and risks, neither of which measure up to perceptions, researchers say.
Medscape Medical News

Aneurysm Recurrence Reduced by Hydrogen Coil in HEAT Trial

Wed, 17 Apr 2019 10:41:05 +0000

The randomized HEAT trial shows the second-generation hydrogel coil was superior to the bare platinum coil in reducing aneurysm recurrence rates.
Medscape Medical News

'Milestone' Meeting Highlights NIH Efforts to Combat ME/CFS

Wed, 17 Apr 2019 07:54:54 +0000

Myalgic encephalomyelitis/chronic fatigue syndrome has become the focus of serious attention by the NIH, and funded research is showing results, but the funding level still does not match the need.
Medscape Medical News

Фанатов "Звёздного пути" призвали отказаться от курения

Wed, 17 Apr 2019 10:03:23 +0000

Актриса Сьюзан Нимой, вдова актера Леонарда Нимоя, который наиболее известен по роли мистера Спока в сериале «Звездный путь», приняла участие в кампании против курения, которую проводит Американский Центр по профилактике и контролю заболеваемости (CDC).

New York's Rockland County Issues New Actions to Fight Measles

Tue, 16 Apr 2019 19:19:17 +0000

Rockland County health officials order new restrictions and requirements to stem the ongoing and worsening measles outbreak in the New York City suburb.
Medscape Medical News

Mom's Gestational Diabetes Ups Type 1 Diabetes Risk in Kids

Tue, 16 Apr 2019 16:47:16 +0000

If a child develops polyuria, polydipsia, weight loss, or fatigue, and his or her mother had gestational diabetes, test for diabetes, says the lead author of a new study.
Medscape Medical News

Volunteer Doctors Struggle to Provide Care on the Border

Tue, 16 Apr 2019 17:43:03 +0000

In the absence of a coordinated federal response, nonprofit organizations across the 1,900-mile southern border have stepped in to provide food, shelter, and medical care to immigrants.
Kaiser Health News

FDA Clears Plenity Hydrogel Capsules for Weight Management

Tue, 16 Apr 2019 17:43:09 +0000

The FDA has cleared Gelesis100 for weight management in adults with a body mass index of 25 – 40 kg/m2, when used together with diet and exercise.
FDA Approvals

ACP Lays Out Plan to Redesign Affordable Care

Tue, 16 Apr 2019 16:38:37 +0000

The American College of Physicians (ACP) recommends scrapping the cap for tax credit eligibility, establishing a public option to ensure affordable coverage, and starting automatic re-enrollment.
Medscape Medical News

Class I Recall of Brainlab 3D Surgical Navigation Software

Tue, 16 Apr 2019 15:10:45 +0000

The software used with Brainlab's Spine & Trauma Navigation System could display inaccurate information that may prevent the surgeon from accurately navigating surgical tools during surgery.
News Alerts

Teprotumumab, Canagliflozin, and Kevin Pho Top AACE Agenda

Tue, 16 Apr 2019 15:38:35 +0000

Graves' ophthalmopathy, type 2 diabetes treatment, social media matters, and much more to be featured at Los Angeles conference.
Medscape Medical News

Cannabis Users May Need More Anesthesia for Surgery

Tue, 16 Apr 2019 14:37:31 +0000

People who regularly use cannabis may need more than twice the usual dose of anesthesia for surgery, a U.S. study suggests.
Reuters Health Information

Multidrug-Resistant Bacteria Found on Patient Hands, Surfaces

Tue, 16 Apr 2019 14:36:47 +0000

Multidrug-resistant bacteria were found on many hospitalized patients' hands and on commonly touched surfaces in their rooms. They could be a reservoir for hospital-acquired infections, a study indicates.
Medscape Medical News

FDA Pulls All Vaginal Mesh Products Off the Market

Tue, 16 Apr 2019 14:48:05 +0000

The FDA said the manufacturers of vaginal mesh failed to provide reasonable assurance that the products are safe and effective.
News Alerts

Emergency-Medicine Residents Often Miscalculate IV Doses for Kids

Tue, 16 Apr 2019 13:02:33 +0000

Emergency-medicine residents often miscalculate doses for a variety of intravenous medications used to treat children, according to new findings.
Reuters Health Information

Hyponatremia Linked to Metabolic Bone Disease in Epilepsy

Tue, 16 Apr 2019 13:13:19 +0000

In patients with epilepsy, hyponatremia - a common side effect of several antiepileptic drugs (AEDs) - is independently associated with decreased bone-mineral density (BMD) and an increased risk of osteoporosis, researchers from Denmark report.
Reuters Health Information

U.S. Supreme Court Rejects Allergan Bid to Use Tribe to Shield Drug Patents

Tue, 16 Apr 2019 13:26:42 +0000

The U.S. Supreme Court on Monday cast aside pharmaceutical company Allergan Plc's unorthodox bid to shield patents from a federal administrative court's review by transferring them to a Native American tribe.
Reuters Health Information

Smartphone App Helps Predicts Abdominal Incisional Hernia

Tue, 16 Apr 2019 13:36:45 +0000

One out of every eight patients who undergo abdominal surgery will develop an incisional hernia and a new smartphone app developed by a team from the University of Pennsylvania Perelman School of Medicine can accurately predict a patient's risk for IH at the bedside.
Reuters Health Information

Lengthier Dialysis Doesn't Translate to Longer Life

Tue, 16 Apr 2019 13:06:42 +0000

A comparison of extended and standard dialysis hours yielded disappointing results and has nephrologists debating next steps for patients who say they feel better with more hours of care.
Medscape Medical News

Which Cryptogenic Stroke Patients Benefit From Anticoagulation?

Tue, 16 Apr 2019 13:39:11 +0000

These may include patients with an enlarged left atrium, a subgroup analysis of the NAVIGATE-ESUS trial suggests.
Medscape Medical News

Exercise Cuts Brain Inflammation in First-Episode Psychosis

Tue, 16 Apr 2019 12:19:29 +0000

Aerobic exercise cuts levels of interleukin-6 in patients with first-episode psychosis, suggesting it may be a promising intervention to reduce the effects of brain inflammation in these patients.
Medscape Medical News

ВОЗ сообщает о четырехкратном росте заболеваемости корью

Tue, 16 Apr 2019 12:01:31 +0000

Количество случаев кори за первые три месяца 2019 года на 300 процентов больше, чем за аналогичный период прошлого года, сообщает Всемирная организация здравоохранения (ВОЗ). В организации указывают, что тенденция роста заболеваемости сохраняется уже третий год.

Лечение статинами не достигает цели у половины пациентов

Tue, 16 Apr 2019 18:14:16 +0000

У половины пациентов, получающих статины с целью профилактики болезней сердца, уровень «плохого холестерина» не снижается в достаточной мере через два года после начала лечения. Причина этой проблемы неизвестна, частично это может быть связано с нерегулярностью приема лекарств.

Приятный запах снизит тягу к сигаретам

Tue, 16 Apr 2019 18:30:04 +0000

Желание взять сигарету и закурить можно перебить, вдохнув аромат шоколада, мяты или ванили. Исследователи отметили способность приятных запахов отвлекать курильщиков от мыслей о собственной тяге к никотину при помощи воспоминаний или ассоциаций, связанных с этими запахами.

'This is Our Lane': Doctors Work to Close Firearm Loopholes

Tue, 16 Apr 2019 10:56:41 +0000

Bills that strengthen background checks and fund gun-violence-prevention research are supported by the American College of Physicians, as are 'red flag' laws being passed by some states.
Medscape Medical News

Apps Designed for People With Type 2 Diabetes Disappoint

Tue, 16 Apr 2019 11:01:13 +0000

Study 'demonstrates the immaturity of diabetes apps and missed opportunities to improve care and health outcomes.'
Medscape Medical News

Liver Cancer Deaths Rising Faster Among Less Educated Adults

Tue, 16 Apr 2019 10:26:24 +0000

The rates of liver cancer-related deaths have been increasing, but this increase is more pronounced in individuals with lower educational attainment.
Medscape Medical News

Sunshine Act May Reduce Patient Trust in Physicians

Tue, 16 Apr 2019 07:43:34 +0000

Researchers see potential for 'unintended consequences,' including loss of trust in physicians, even those who do not have financial ties to drug and device makers.
Medscape Medical News

Low Cholesterol Linked to Higher Hemorrhagic Stroke Risk

Mon, 15 Apr 2019 16:52:02 +0000

High LDL cholesterol is a known risk factor for ischemic stroke, but a new study suggests it may also increase the risk for hemorrhagic stroke.
Medscape Medical News

FDA's Added-Sugar Labeling Policy to Pay Sweet Dividends

Mon, 15 Apr 2019 16:54:12 +0000

The first-of-its-kind study projects striking reductions in cardiovascular disease and type 2 diabetes, coupled with billions in cost savings after implementation of an added-sugar labeling policy.
Medscape Medical News

CDC: 90 New Measles Cases, Nearing Record Since Elimination

Mon, 15 Apr 2019 17:04:22 +0000

A total of 555 measles cases have occurred this year, surpassing 372 last year and approaching 667 in 2014, according to the CDC. Vaccination refusal is the primary driver of the disease outbreaks.
Medscape Medical News

Statins Safe, May Reduce CV Events in RA

Mon, 15 Apr 2019 16:17:18 +0000

Statins are safe and likely effective for preventing cardiovascular events among patients with rheumatoid arthritis, but not every patient with RA needs the drug, new data suggest.
Medscape Medical News

Temporary Shortage of Pediatric Tracheostomy Tubes: FDA

Mon, 15 Apr 2019 16:28:32 +0000

The closing of an ethylene oxide sterilization plant in Illinois has led to a temporary shortage of Bivona tracheostomy tubes manufactured by Smiths Medical.
News Alerts

'Self-Management' Program Cuts Pain, Increases Brain Volume

Mon, 15 Apr 2019 15:22:33 +0000

An intensive, interdisciplinary program focused on self-management of chronic pain is linked to significant symptom improvement and brain volume changes, as shown on objective neuroimaging measures.
Medscape Medical News

Psychostimulants Tied to 1 in 5 Fatal Strokes in Young Adults

Mon, 15 Apr 2019 14:06:16 +0000

Psychostimulants like methamphetamine, cocaine, and MDMA have been tied to a significantly increased risk of fatal stroke in young adults, new research shows.
Medscape Medical News

Atrasentan Back on the SONAR for Diabetes and Kidney Disease

Mon, 15 Apr 2019 14:10:07 +0000

A trial of the experimental drug suggests major benefits for patients with diabetes and chronic kidney disease, an analysis of data conducted after the SONAR study was halted shows.
Medscape Medical News

Some Uncomplicated STEMI Patients May Not Need ICU Care

Mon, 15 Apr 2019 14:44:18 +0000

The trick is identifying which STEMI patients are most likely to need intensive care after an uncomplicated primary PCI. One factor identified in this registry study is ischemia time.
Medscape Medical News

Need to Inject Then Infect a Human to Test Hep C Vaccine

Mon, 15 Apr 2019 13:06:57 +0000

Hepatitis C will not be eradicated without a vaccine, and an effective vaccine needs a challenge test in healthy humans, experts say.
Medscape Medical News

Drug Shortages Have Small Effect on Outpatient Cancer Care

Mon, 15 Apr 2019 13:11:37 +0000

In the outpatient setting, drug shortages have had little effect on chemotherapy treatment among adults with common cancers, say investigators.
Medscape Medical News

Interns Spend Most Time With EMRs, Not Patients

Mon, 15 Apr 2019 13:44:17 +0000

Interns spent most of the day on indirect patient care; most of this time was spent working with electronic medical records (EMRs) and multitasking, according to the iCOMPARE study.
Medscape Medical News

Melatonin Helps Kids With Autism, Ups Parents' Quality of Life

Mon, 15 Apr 2019 11:58:21 +0000

Children with autism and their parents benefited from better sleep offered by prolonged-release melatonin, with improvements in externalizing behavior and quality of life, investigators found.
Medscape Medical News

TNT Approach to Pancreatic Cancer Tied to Improved Survival

Mon, 15 Apr 2019 12:09:23 +0000

Upfront chemotherapy and radiation may allow for surgery and extends postoperative survival in previously unresectable patients.
Medscape Medical News

Don't Use the Word 'Quit' to Get Patients to Stop Smoking

Mon, 15 Apr 2019 12:37:09 +0000

Physicians should treat smoking the way they treat chronic addictions and expect incremental and sporadic improvements, one expert says.
Medscape Medical News

Сложности с одеванием и покупками в среднем возрасте грозят тяжелыми последствиями в старости

Mon, 15 Apr 2019 18:30:21 +0000

По данным исследования, опубликованного в JAMA Internal Medicine, сложности в выполнении рутинных задач в повседневной жизни у людей зрелого возраста указывают на высокий риск госпитализации, помещения в дома престарелых и другие заведения для ухода, а также преждевременной смерти.

Candida auris Spreads Through US Hospitals

Mon, 15 Apr 2019 10:58:38 +0000

The tough new strain of fungus does not act 'like your typical candida,' says an expert from the CDC.
WebMD Health News

NASA Twins Study: Body Changes Over Time in Space

Mon, 15 Apr 2019 11:09:50 +0000

Brothers Scott and Mark Kelly were 51 in March 2015, when Scott began his fourth and longest space mission — commanding the International Space Station for 340 days, which set an American record.
WebMD Health News

More Evidence Schizophrenia Combo Therapy Blunts Weight Gain

Mon, 15 Apr 2019 11:43:02 +0000

The combination of olanzapine and samidorphan, shown to mitigate the weight gain observed with olanzapine alone in ENLIGHTEN-2, continues to prevent weight gain, new results from an extension study show.
Medscape Medical News

Три четверти врачей считают льготные лекарства недоступными для пациентов

Mon, 15 Apr 2019 17:55:13 +0000

Именно столько врачей подтвердили, что знают о случаях отказа пациентам в выписке льготных лекарств из-за их отсутствия в аптеках, а также о нехватке необходимых лекарств в больницах. Лучше всего ситуация обстоит с лекобеспечением пациентов с болезнями кровообращения, но даже в этом случае положительно оценивает доступность льготных препаратов менее половины опрошенных медиков.

Gluten-Free Diet May Ease Schizophrenia Symptoms

Mon, 15 Apr 2019 10:12:46 +0000

A gluten-free diet may reduce symptoms in a particular subset of patients with schizophrenia, early research suggests.
Medscape Medical News

No Benefit in Adding Cannabis to Opioids for Pain

Mon, 15 Apr 2019 10:17:12 +0000

Amid growing support for cannabis in the treatment of chronic pain, a new study is the latest to show no improvement in pain by adding cannabis to opioid treatment.
Medscape Medical News

Patients Pay More for Growth Hormone, Suffer Restrictions on Use

Mon, 15 Apr 2019 09:09:49 +0000

Fearing an explosion of scripts when the indication for human growth hormone was expanded to include ISS, US insurance companies increased patient cost-sharing and instituted coverage restrictions.
Medscape Medical News

Smartphone Apps Effective for Mindfulness Program Delivery

Mon, 15 Apr 2019 09:11:36 +0000

Patients with busy schedules that preclude attending weekly mindfulness sessions experience significant reductions in anxiety with a smartphone app-based program.
Medscape Medical News

Novel Suicide Prediction Tool Goes Beyond Patient Self-Reports

Mon, 15 Apr 2019 09:44:25 +0000

Efforts to refine instruments to predict and prevent suicides should consider clinicians' responses, as well as proposed suicide crisis syndrome DSM criteria, new research suggests.
Medscape Medical News

Obesity Trends Reversed in Children on Food Voucher Program

Mon, 15 Apr 2019 09:45:09 +0000

Trends in childhood obesity declined among WIC participants following healthy changes to the food package for women, infants, and children in lower-income families.
Medscape Medical News

Brain Damage From Alcohol Continues After Abstinence

Mon, 15 Apr 2019 08:19:07 +0000

Damage to the brain caused by alcohol continues during the first few weeks of abstinence, a finding that refutes the notion that the brain begins to normalize immediately after individuals stop drinking.
Medscape Medical News

Diabetes Drug 'Home Run' Curtailing Kidney Failure Risk

Mon, 15 Apr 2019 08:37:28 +0000

Canagliflozin also showed cardiovascular benefits in the CREDENCE multicenter trial, with no imbalance in adverse events, investigators shared here at the nephrology world congress.
Medscape Medical News

Medical Groups Support Bid to Add 15,000 Residency Slots

Mon, 15 Apr 2019 07:27:29 +0000

Hospital and physician organizations are pressing lawmakers to expand Medicare funding for graduate medical education.
Medscape Medical News

Дети, которые живут возле крупных дорог, чаще отстают в развитии

Mon, 15 Apr 2019 12:36:10 +0000

У детей, которые живут рядом с крупными автомагистралями, увеличивается риск не только физических болезней. Они, как выяснили ученые, примерно в два раза чаще получают более низкие оценки в тестах коммуникационных навыков по сравнению с теми, кто живет дальше от дорог.

«Цифровой контур – это не только информационные технологии и программное обеспечение»

Sat, 13 Apr 2019 17:46:22 +0000

В России должны быть созданы условия для полноценного взаимодействия в рамках ЕГИСЗ – единой государственной информационной системы в сфере здравоохранения. Предполагается, что это позволит повысить эффективность управления, точность статистики и качество медицинской помощи. О «цифровой трансформации» отрасли говорили на Международном форуме по цифровой медицине.

Home-Dialysis Patients Fare Better

Sat, 13 Apr 2019 10:39:55 +0000

Patients with kidney failure do better with home dialysis, new research shows, but uptake is generally low and requires motivation and education, experts say.
Medscape Medical News

Texas Tech Agrees To Stop Using Race in Med School Admissions

Fri, 12 Apr 2019 19:08:38 +0000

The AAMC notes that the agreement does not change current law and said it will continue to support the use of race in the holistic admissions process.
Medscape Medical News

French Court Finds Bayer's Monsanto Liable for Farmer's Sickness

Fri, 12 Apr 2019 16:52:00 +0000

A French court has ruled that Monsanto was liable for the sickness of a farmer who inhaled one of its weedkillers, in another legal setback for the Bayer-owned business over health claims.
Reuters Health Information

Teen Cigarette Smoking Declining More Slowly in Rural U.S.

Fri, 12 Apr 2019 16:44:23 +0000

The odds of smoking for U.S. adolescents are 50 percent higher in rural areas than in urban areas, even as rates of teen smoking in both settings have fallen, a recent study found.
Reuters Health Information

Afghan Taliban Bans WHO and Red Cross Work Amid Vaccination Drive

Fri, 12 Apr 2019 16:21:34 +0000

The Afghan Taliban have banned the World Health Organization and the Red Cross from operating in areas under their control until further notice, a spokesman said on Thursday, citing unspecified "suspicious" actions during vaccination campaigns.
Reuters Health Information

N.Y. State to Sue EPA: Agency Approval on GE Hudson River Clean-Up Premature

Fri, 12 Apr 2019 16:15:46 +0000

New York state officials announced plans to sue the U.S. Environmental Protection Agency for prematurely declaring that General Electric Co had completed its clean-up of PCB contamination in the Hudson River.
Reuters Health Information

U.S. Military Advances Sprawling Mission to Quell Housing-Safety Scandal

Fri, 12 Apr 2019 16:10:20 +0000

One U.S. military base has dubbed it Operation Victory Homefront. It's a mission the world's most powerful military never envisioned.
Reuters Health Information

Housework Leads Some Proceduralist Moms to Rethink Specialty

Fri, 12 Apr 2019 16:12:10 +0000

Physician mothers are responsible for the bulk of domestic tasks, and this disparity leads many in procedural specialties to consider changing their career or specialty, a study has found.
Medscape Medical News

Paclitaxel-based Devices in PAD: Operating Under a Dark Cloud

Fri, 12 Apr 2019 16:30:41 +0000

Professional societies are following in the footsteps of the FDA and urging members to shy away from use of the devices in peripheral artery disease (PAD).
Medscape Medical News

Duodenoscope Contamination Rates Still Lethally High: FDA

Fri, 12 Apr 2019 16:38:24 +0000

New data show 'high-concern' bacteria on 5.4% of properly reprocessed scopes; FDA reports three deaths in 2018 related to contaminated duodenoscopes.
News Alerts

HIV-1 Envelope Protein Opening Exposes Antibody Targets

Fri, 12 Apr 2019 16:00:46 +0000

An asymmetric opening of the HIV-1 envelope protein (Env) exposes targets that induce antibody-dependent cellular cytotoxicity (ADCC), researchers report.
Reuters Health Information

Video-Visit-Proficient Practices Are Wasting Capability

Fri, 12 Apr 2019 15:02:30 +0000

Having telehealth technology available does not mean it is being used, results of a new survey show, but the American College of Physicians is launching an initiative to help practices get started.
Medscape Medical News

First Drug for Fatty Liver Disease Advances

Fri, 12 Apr 2019 14:09:41 +0000

Obeticholic acid has hit a statistically significant result at 18 months in the REGENERATE trial evaluating the farnesoid X receptor agonist in patients with nonalcoholic steatohepatitis.
Medscape Medical News

Marijuana May Improve Women's Enjoyment of Sex

Fri, 12 Apr 2019 12:28:46 +0000

About one-third of U.S. women have used marijuana before sex, a small study suggests, and those who do report increased desire and better orgasms.
Reuters Health Information

'Prehab,' SSRIs May Reduce Postsurgical Opioid Use

Fri, 12 Apr 2019 11:50:09 +0000

A strict preoperative rehabilitation protocol (prehab) may reduce opioid use after spinal surgery, while use of antidepressants is linked to reduced opioid use after knee surgery, new studies suggest.
Medscape Medical News

PRAC Restricts Use of Alemtuzumab for MS Pending Ongoing Review

Fri, 12 Apr 2019 12:09:33 +0000

The EMA committee recommends updating the product information to note the potential for acute immune-mediated conditions, stroke, cervicocephalic arterial dissection, and severe neutropenia.
News Alerts

У молодых людей все чаще обнаруживают неалкогольную жировую болезнь печени

Fri, 12 Apr 2019 18:37:09 +0000

Эксперты предупреждают о резком росте заболевания неалкогольной жировой болезнью печени среди молодежи. По всей видимости, рост заболеваемости связан с избыточным весом молодых людей.

More U.S. States Push Ahead With Near-Bans on Abortion for Supreme Court Challenge

Fri, 12 Apr 2019 10:56:14 +0000

North Dakota Republican Governor Doug Burgum signed legislation on Wednesday making it a crime for doctors to perform a second-trimester abortion using instruments like forceps and clamps to remove the fetus from the womb.
Reuters Health Information

Laparoscopy Still Most Popular Hysterectomy Approach After Morcellation Warnings

Fri, 12 Apr 2019 11:15:15 +0000

Laparoscopy remains the most common mode of hysterectomy since an April 2014 U.S. Food and Drug Administration (FDA) warning against power morcellation for laparoscopic specimen removal, according to a database study.
Reuters Health Information

Earlier Onset of Type 1 Diabetes Linked to Weaker Bones

Fri, 12 Apr 2019 11:22:47 +0000

Postmenopausal women with type 1 diabetes (T1D) have lower volumetric bone-mineral density (vBMD) than their diabetes-free peers, and bone-quality deficits may be even greater for those who developed the disease before age 20, according to new findings.
Reuters Health Information

Rare Genetic Variants Tied to Alzheimer's Disease

Fri, 12 Apr 2019 11:31:53 +0000

Two rarely encountered genetic variants that already have roles in dementias also appear to be associated with Alzheimer's disease (AD), according to a large genetic study.
Reuters Health Information

Blood Test Speeds Preeclampsia Diagnosis, Improves Outcomes

Fri, 12 Apr 2019 11:18:42 +0000

Placental growth factor blood test speeds diagnosis of preeclampsia. The National Health Service plans to make the test widely available across the UK.
Medscape Medical News

FDA Modifies Alcohol Warning for Addyi, So-called 'Female Viagra'

Fri, 12 Apr 2019 10:29:00 +0000

Women taking flibanserin, so-called 'female Viagra,' no longer have to completely avoid alcohol but should stop drinking at least 2 hours before taking the pill at bedtime or skip the evening dose.
Medscape Medical News

Five Staff Resign at Leading UK Transgender Youth Clinic

Fri, 12 Apr 2019 10:29:39 +0000

An investigation by the UK's Times newspaper finds that five staff members at a London clinic for young people with gender dysphoria have resigned because of concerns over treatment.
Medscape Medical News

В Москве начал работу Международный форум по цифровой медицине

Fri, 12 Apr 2019 14:25:57 +0000

Крупнейшее в России мероприятие, посвященное цифровым технологиям в области здравоохранения, объединило представителей 10 стран мира: ключевых специалистов и лидеров рынка биометрических и информационных технологий, разработчиков и инвесторов, врачей всех областей.

Слишком низкий уровень "вредного холестерина" связали с риском кровоизлияния в мозг

Fri, 12 Apr 2019 13:05:08 +0000

Высокий уровень липопротеидов низкой плотности ("плохого хоелстерина") в крови давно известен как фактор иска сердечно-сосудистых болезней. В новом исследовании ученые обнаружили, что его слишком малое количество также опасно: у женщин оно связано с увеличением вероятности геморрагического инсульта.

[Series] Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia

Thu, 11 Apr 2019 23:00:08 +0000

Opioids are a mainstay of acute pain management but can have many adverse effects, contributing to problematic long-term use. Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical increase in pain with opioid administration) can contribute to both poorly controlled pain and dose escalation. Hyperalgesia is particularly problematic as further opioid prescribing is largely futile. The mechanisms of opioid tolerance and hyperalgesia are complex, involving μ opioid receptor signalling pathways that offer opportunities for novel analgesic alternatives.

[Series] Inappropriate opioid prescription after surgery

Thu, 11 Apr 2019 23:00:08 +0000

Worldwide, the use of prescription opioid analgesics more than doubled between 2001 and 2013, with several countries, including the USA, Canada, and Australia, experiencing epidemics of opioid misuse and abuse over this period. In this context, excessive prescribing of opioids for pain treatment after surgery has been recognised as an important concern for public health and a potential contributor to patterns of opioid misuse and related harm. In the second paper in this Series we review the evolution of prescription opioid use for pain treatment after surgery in the USA, Canada, and other countries.

[Series] Transition from acute to chronic pain after surgery

Thu, 11 Apr 2019 23:00:08 +0000

Over the past decade there has been an increasing reliance on strong opioids to treat acute and chronic pain, which has been associated with a rising epidemic of prescription opioid misuse, abuse, and overdose-related deaths. Deaths from prescription opioids have more than quadrupled in the USA since 1999, and this pattern is now occurring globally. Inappropriate opioid prescribing after surgery, particularly after discharge, is a major cause of this problem. Chronic postsurgical pain, occurring in approximately 10% of patients who have surgery, typically begins as acute postoperative pain that is difficult to control, but soon transitions into a persistent pain condition with neuropathic features that are unresponsive to opioids.

[Clinical Picture] Delayed Strongyloides stercoralis hyperinfection syndrome in a renal transplant patient with Pneumocystis jirovecii pneumonia receiving high-dose corticosteroids

Thu, 11 Apr 2019 23:00:08 +0000

A 50-year old man who had not travelled outside the UK for the past 20 years—but who had lived in Angola for most of his childhood—presented at our clinic with a 4-week history of worsening exercise tolerance. The patient had undergone renal transplantation 2 years and 6 years previously. Since transplantation, his estimated glomerular filtration rate had been slowly decreasing, most likely due to chronic graft rejection, and he was therefore on high-dose immunosuppression treatment with tacrolimus 8 mg twice daily, mycophenolate mofetil 500 mg twice daily, and prednisolone 5 mg once daily.

[Articles] Association between interpregnancy interval and adverse birth outcomes in women with a previous stillbirth: an international cohort study

Thu, 11 Apr 2019 23:00:08 +0000

Conception within 12 months of a stillbirth was common and was not associated with increased risk of adverse outcomes in the subsequent pregnancy. These findings could be used when counselling women who are planning future pregnancies after a stillbirth and for informing future recommendations for pregnancy spacing in a high-income setting.

[Articles] Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial

Thu, 11 Apr 2019 23:00:08 +0000

Frequently repeated mass administrations of ivermectin during the malaria transmission season can reduce malaria episodes among children without significantly increasing harms in the populace.

[Articles] Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial

Thu, 11 Apr 2019 23:00:08 +0000

Selective laser trabeculoplasty should be offered as a first-line treatment for open angle glaucoma and ocular hypertension, supporting a change in clinical practice.

[Department of Error] Department of Error

Thu, 11 Apr 2019 23:00:08 +0000

Hamada H, Suzuki H, Onouchi Y, et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 2019; 393: 1128–37—In table 1 of this Article, some data in the second column of the row entitled “C-reactive protein, mg/dL” was incorrect and should have read “9·46 (5·73–12·6)”.

[Correspondence] Science's place in shaping gender-based policies in athletics

Thu, 11 Apr 2019 23:00:07 +0000

In 2009, South African runner Caster Semenya, aged 18 years, won the 800 m at the World Championships in Athletics in Berlin, only to be rapidly declared “a woman, but maybe not 100%” by the general secretary of the International Association of Athletic Federations (IAAF), and barred from competing. After being reinstated, she won Olympic Gold in 2012 and 2016 and became the 800 m World Champion in London in 2017. However, by the time the World Championships in Athletics take place between Sept 28 and Oct 6, 2019, new eligibility regulations for female classification from the IAAF,1 based on the interpretation of data2 from studies of androgen concentrations in elite athletes, might have prevented Semenya from competing again.

[Correspondence] The NUTRIREA-2 study – Authors' reply

Thu, 11 Apr 2019 23:00:07 +0000

We thank correspondents for their comments on the NUTRIREA-2 trial.1 We agree with Simon Bourcier and Alain Combes that bowel ischaemia is challenging to diagnose and can be caused by different mechanisms, including non-occlusive mesenteric ischaemia and vessel obstruction. Moreover, we agree that the unblinded study design could have caused detection bias. These points were clearly acknowledged in the discussion. However, predefined criteria were used in the NUTRIREA-2 trial to diagnose bowel ischaemia.

[Correspondence] The NUTRIREA-2 study

Thu, 11 Apr 2019 23:00:07 +0000

In the NUTRIREA-2 trial,1 enteral nutrition was compared with parenteral early nutrition in ventilated adults with shock. In particular, the authors aimed at ascertaining whether early first-line enteral nutrition showed positive clinical effects compared with parenteral nutrition. Both arms of the study targeted normocaloric supplementation in patients needing invasive mechanical ventilation and vasopressor support for shock.1 The results show that early isocaloric enteral and parenteral nutrition did not differ in mortality or risk of secondary infections.

[Correspondence] The NUTRIREA-2 study

Thu, 11 Apr 2019 23:00:07 +0000

In the NUTRIREA-2 trial,1 patients who received mechanical ventilation and vasopressor support showed no statistically significant differences in mortality and infection rates when given either enteral nutrition or parenteral nutrition. Enteral nutrition was more frequently associated with adverse gastrointestinal events. Full doses of macronutrients corresponding to about 60–70% of daily requirements were provided throughout the intervention period.1,2 Such a calorie target might attenuate the potential benefit of enteral nutrition and increase the risk of complications related to enteral nutrition.

[Correspondence] The NUTRIREA-2 study

Thu, 11 Apr 2019 23:00:07 +0000

We read with interest the results of the NUTRIREA-2 study by Jean Reignier and colleagues (Jan 13, 2018, p 133).1 In this well designed, open-label, randomised controlled trial, enteral nutrition did not improve mortality at day 28 compared with parenteral nutrition with a normocaloric target in mechanically ventilated patients with shock. A major finding of this study was the significantly higher rate of bowel ischaemia in the enteral group (19 [2%] patients vs five [<1%] patients; p=0·007), leading the authors to conclude that enteral nutrition might promote gut ischaemia in critically ill patients.

[Correspondence] Populations, decreasing fertility, and reproductive health

Thu, 11 Apr 2019 23:00:07 +0000

The Article by the Global Burden of Disease 2017 Population and Fertility Collaborators (Nov 10, 2018, p 1995)1 conveys an extremely important message about international population trends that have so far received little public attention. For more than 40 years, birth rates in industrialised countries with high economic activity have been below the replacement levels of 2·1 children per woman. As a result, populations in highly industrialised countries such as Japan, Germany, Switzerland, and Singapore are ageing.

[Correspondence] Indigenous Australian children and the impact of adoption legislation in New South Wales

Thu, 11 Apr 2019 23:00:07 +0000

Despite widespread opposition from the community, during the final days of 2018, the Parliament of New South Wales (Australia) passed legislation imposing an arbitrary 24 months for children in out-of-home care to be reunited with their families, before adoption can become permanent. The new laws enable a 2 year limit on the creation of permanent arrangements for a child, guardianship orders that can be arranged without parental consent, amendments to the application process of family restoration, and removal of parental consent for adoption on permanent orders.

[Correspondence] Keeping promises to women, children, and adolescents

Thu, 11 Apr 2019 23:00:07 +0000

By 2015, at the end of the Millennium Development Goals (MDGs) era, each year more than 6 million children younger than 5 years and 1 million adolescents were dying each year and more than 300 000 maternal deaths were occurring every year.1 These deaths are a substantial health problem and social injustice because most cases are preventable and are concentrated in rural populations and poorer communities in sub-Saharan Africa and south Asia. Within the context of the Sustainable Development Goals (2016–30) the UN Secretary General launched the Global Strategy for Women's, Children's, and Adolescents' Health (henceforth referred to as the Global Strategy).

[Obituary] William Carter Jenkins

Thu, 11 Apr 2019 23:00:07 +0000

Epidemiologist and whistleblower on notorious Tuskegee study. Born July 26, 1945, in Mount Pleasant, SC, USA, he died of complications of sarcoidosis on Feb 17, 2019, in Charleston, SC, USA, aged 73 years.

[Perspectives] Closure or retribution?

Thu, 11 Apr 2019 23:00:07 +0000

In a shared house in downstate Illinois, Andy (an intense performance by Tim Hopper), a man in his forties, sits on a sofa trying to express his feelings of anger and low self-esteem to Fred (a creepy Francis Guinan), an elderly man who uses a wheelchair. But he is constantly interrupted by the arrival of other people and phone calls. What seems to be a comical situation is instead the wrong-footed opening of Bruce Norris's incendiary play Downstate, directed by Pam MacKinnon in a co-production with Steppenwolf Theatre at the National Theatre, London, UK.

[Perspectives] Disease X and other unknowns

Thu, 11 Apr 2019 23:00:07 +0000

On Feb 26, 2003, Carlo Urbani, an infectious diseases specialist in WHO's country office in Vietnam, was called to the French Hospital in Hanoi to examine a grievously ill Chinese-American businessman. Johnny Chen had been admitted with severe breathing difficulties shortly after stepping off a flight from Hong Kong and was being nursed in intensive care, where x-rays revealed ominous shadows on his lungs. Fearing Chen had a virulent form of avian influenza, Urbani convinced the Vietnamese authorities to quarantine the hospital and made staff wear high-filter masks and double gowns.

[Perspectives] Ramani Moonesinghe: anaesthetist with a perioperative vision

Thu, 11 Apr 2019 23:00:07 +0000

“I am a clinical academic who strives to improve perioperative care”, states the opening sentence of anaesthetist Professor Suneetha Ramani Moonesinghe's CV. And strive she does if the number of research groups and advisory bodies that she variously directs or belongs to is a relevant metric. “There are lots of people in academic medicine who are personally ambitious and driven”, says Viki Mitchell, one of Moonesinghe's fellow anaesthetists at London's University College Hospital (UCH) and its Divisional Clinical Director for Anaesthesia and Perioperative Medicine.

[Perspectives] Writing the body

Thu, 11 Apr 2019 23:00:07 +0000

What is the thing called you? When I was admitted to hospital with abdominal pain in my twenties, I asked the doctor giving me an ultrasound to show me around my own interior. Bladder, uterus, appendix: so this was me, after all this time, although I didn't feel nearly so naked examining my guts on a screen as I did a day later, when a surgeon came to look at the stitches where he'd sealed me up after an appendectomy. Our bodies are as personal as you can get, but they're also alien and unknown, the inner self inaccessible as another planet, at least under normal circumstances.

[Perspectives] Digital health care for older adults

Thu, 11 Apr 2019 23:00:07 +0000

Leila is an 86-year-old woman with type 2 diabetes and high blood pressure. She lives alone, and, as a result of a recent heart attack, her family doctor and cardiologist want to see her more frequently. She has some moderate arthritis involving her knees and hips and poor vision, but she is committed to maintaining her independence.

[World Report] Italy calls on retired doctors to fill health worker gap

Thu, 11 Apr 2019 23:00:07 +0000

Experts say that the shortfall of doctors has been fuelled by poorly conceived policies for health worker recruitment dating back 10 years. Marta Paterlini reports.

[World Report] Health debate rising around the upcoming Indian election

Thu, 11 Apr 2019 23:00:07 +0000

The BJP will be promoting its Ayushman Bharat scheme further, while the main party in opposition decries an insurance-based model. Patralekha Chatterjee reports from New Delhi and Haryana.

[World Report] International outrage over Brunei's discriminatory laws

Thu, 11 Apr 2019 23:00:07 +0000

The egregious laws would disproportionately affect LGBT communities and women, experts say. Sharmila Devi reports.

[Comment] Offline: Facing down the violence of liberal communists

Thu, 11 Apr 2019 23:00:07 +0000

Knife crime. School shootings. Islamophobic and anti-Semitic killings. Sexual violence. Child maltreatment. Gangs. Guns. War. Anthropologist Alain Bertho calls our time the Age of Violence (the title of his 2018 book)—“this is an era conducive to the most varied of murderous follies”. Last week, Britain's Prime Minister and her Home Secretary (Theresa May and Sajid Javid) used a Serious Youth Violence Summit, held at 10 Downing Street, to launch a new approach to violence. What they propose seems to make a great deal of sense.

[Comment] Guidelines for the diagnosis and treatment of Chagas disease

Thu, 11 Apr 2019 23:00:07 +0000

Chagas disease, caused by the protozoan Trypanosoma cruzi, constitutes a substantial public health concern due to its high morbidity and mortality rates among people typically in low-income populations who often do not have access to timely medical diagnosis and treatment. There are also high economic and social costs generated by the disease. Despite successful and sustained vector control policies and screening of blood and organs for donation, more than 6 million people still live with Chagas disease in the Americas, most of them unaware of their infection.

[Comment] Optimal postoperative pain management: redefining the role for opioids

Thu, 11 Apr 2019 23:00:07 +0000

Fear of pain is deeply rooted among patients who are about to have surgery.1 Satisfactory perioperative pain management is crucial to assuring a good patient experience, optimising postoperative outcomes, and enhancing functional recovery after surgery.2 Despite decades of research showing the benefits of various new analgesic strategies, many patients endure severe postoperative pain,3 and this holds true across all age groups and continents, even after surgery widely considered to be minor.4 A 2016 study from the USA, which enrolled 799 449 patients, showed that reliance on opioid analgesics as the mainstay for perioperative pain management is still widespread.

[Comment] Interpregnancy interval after stillbirth: modifiable, but does it matter?

Thu, 11 Apr 2019 23:00:06 +0000

Interpregnancy interval, defined as the time from the end of one pregnancy to the conception of the next, has been studied for nearly a century as a risk factor for adverse outcome (miscarriage, perinatal death, preterm birth, low birthweight, and small-for-gestational-age birth) in the next pregnancy.1,2 There is consistent evidence that pregnancies conceived less than 18–24 months after a livebirth are at increased risk of adverse outcomes,1 although recent studies, using a novel design that compares women with three or more births (and therefore two or more intervals) to themselves,3–6 have questioned this conclusion.

[Comment] Advancing the repurposing of ivermectin for malaria

Thu, 11 Apr 2019 23:00:06 +0000

There is ever-increasing anticipation for the potential of mass drug administration of endectocides (also known as systemic insecticides) to reduce malaria transmission, with ivermectin emerging as the most likely first-in-class endectocide.1 More than half of the 46 papers published on this subject in the past decade appeared in the past 2 years. 23 projects are registered in the MESA Track database, of which seven are active today; and, more importantly, trial mapping by the Malaria Ivermectin Roadmap2 shows that abundant new evidence on the topic will be available by 2020.

[Comment] Laser trabeculoplasty as first-line glaucoma treatment

Thu, 11 Apr 2019 23:00:06 +0000

The efficacy of laser trabeculoplasty as treatment for open-angle glaucoma is established.1,2 The role of laser trabeculoplasty as first-line treatment was first reported in 1990: the Glaucoma Laser Trial3 showed that in patients with newly diagnosed primary open-angle glaucoma, argon laser trabeculoplasty was an effective and safe first-line therapy compared to topical timolol. Selective laser trabeculoplasty, which has the advantage of causing less target tissue disruption, superseded argon laser trabeculoplasty as the laser treatment of choice.

[Editorial] Artificial intelligence in global health: a brave new world

Thu, 11 Apr 2019 23:00:06 +0000

Despite decades of progress in global health, many low and middle income countries are not reaching their health Sustainable Development Goals, creating a sense of urgency to prioritise health in resource-strained environments. The use of artificial intelligence (AI) is becoming increasingly attractive to the health-care industry. The accompanying enthusiasm remains awkwardly placed somewhere between aspiration and reality.

[Editorial] Best practice in managing postoperative pain

Thu, 11 Apr 2019 23:00:06 +0000

Controlling acute pain after surgery is important not only in the immediate postoperative phase but also to prevent chronic postsurgical pain, which can develop in as many as 10% of patients. A Series of three papers in this week's issue examines postoperative pain management, outlines how and why acute pain can become chronic, what can be done to lessen that risk, and the role of opioids.

[Editorial] Post-Castro Cuba: new constitution expands health rights

Thu, 11 Apr 2019 23:00:06 +0000

2019 marks the 60th anniversary of the 26th of July Movement, which established Fidel Castro as the leader of the new Cuban Government. Decades later, Cuba is holding fast to its Communist ideology, even after revolutionary icon Fidel Castro's death in 2016 and his brother Raúl stepping down in 2018. Although the grip on power of the so-called historic generation is loosening, the new generation has “demonstrated capacity to uphold the banners of…Revolution and Socialism”, as Raúl Castro noted in 2013.

Visits to the Emergency Department Reach New High in CDC Data

Thu, 11 Apr 2019 17:13:40 +0000

Fewer than 5% of patients came to the ED for nonurgent reasons, CDC data show.
Medscape Medical News

Brain Imaging Reveals Neuroinflammation in Migraine With Aura

Thu, 11 Apr 2019 15:53:05 +0000

Previous research suggests that neuroinflammation is involved with migraine. A new imaging study identifies its role in migraine with aura as well.
Medscape Medical News

Obesity a Key Driver of Multiple Sclerosis Risk

Thu, 11 Apr 2019 16:28:48 +0000

Ties between early puberty and an increased risk for multiple sclerosis appear to be largely driven by increased body weight, supporting the need for obesity prevention efforts.
Medscape Medical News

Растительные средства могут быть опасными при беременности

Thu, 11 Apr 2019 22:52:30 +0000

Во время беременности нужно помнить, что даже «безобидные» растительные средства могут оказаться опасными. Шотландские ученые сделали обзор 74 ранее опубликованных исследований и показали, что некоторые виды растительных биодобавок связаны с повышенным риском осложнений беременности, включая преждевременные роды и кесарево сечение.

Molecular Classifier Helps Spot Idiopathic Pulmonary Fibrosis

Thu, 11 Apr 2019 15:45:47 +0000

A molecular classifier based on RNA-sequencing data from transbronchial lung biopsies can recognize an expression signature associated with usual interstitial pneumonia (UIP), the defining pathology of idiopathic pulmonary fibrosis (IPF).
Reuters Health Information

House Lawmakers Grill Drugmakers, PBMs on Insulin Cost

Thu, 11 Apr 2019 15:37:03 +0000

Ahead of a Wednesday hearing, Sanofi announced a plan to offer insulin for $99 a month. Cigna also recently made a similar price-cutting move amid congressional inquiries into insulin costs.
Medscape Medical News

Long-Acting Injectables Yield Similar Benefit in Schizophrenia

Thu, 11 Apr 2019 15:50:52 +0000

Aripiprazole lauroxil once every 2 months provided similar significant improvement in schizophrenia symptoms as once per month paliperidone palmitate.
Medscape Medical News

Few Family Caregivers Get Formal Training

Thu, 11 Apr 2019 14:10:43 +0000

Fewer than one in 10 family caregivers receive training for assisting older adults with disabilities, a U.S. study suggests.
Reuters Health Information

RV Pacing May Worsen Even Preserved-EF Heart Failure

Thu, 11 Apr 2019 14:08:48 +0000

A randomized clinical trial is needed, experts say, to determine whether CRT should be preferred in this setting, as is the case for reduced-EF heart failure.
Medscape Medical News

Whole-Body Cryotherapy a Hot New Treatment for Depression?

Thu, 11 Apr 2019 14:22:34 +0000

The idea of eventually offering cryotherapy as an adjunct to standard depression treatment has been proposed by investigators after finding the procedure improves mood and depressive symptoms.
Medscape Medical News

High IQ No Protection Against Suicidal Thoughts in Youth

Thu, 11 Apr 2019 14:27:47 +0000

Contrary to the common belief that adolescents who are more intelligent are less likely to contemplate suicide, new research suggests that superior intelligence isn't necessarily protective.
Medscape Medical News

'Concerning' Sociodemographic Disparities in End-of-Life Care for Kids

Thu, 11 Apr 2019 13:30:38 +0000

Neighborhood income and race/ethnicity are tied to the intensity of end-of-life care in U.S. children with complex chronic conditions, researchers report.
Reuters Health Information

Hep B More Complex Than C, But Here's a Plan to Cure It Too

Thu, 11 Apr 2019 13:44:19 +0000

A new global strategy is designed to accelerate a cure for hepatitis B, which affects millions of people around the world.
Medscape Medical News

Once-Weekly Ketamine Infusions Keep Resistant Depression at Bay

Thu, 11 Apr 2019 11:30:35 +0000

The effects of ketamine are dramatic and rapid but short-lived. New research suggests once-weekly infusions can maintain its efficacy.
Medscape Medical News

«Йодированная соль – не лечебная добавка. Это обычный необходимый каждому пищевой продукт»

Thu, 11 Apr 2019 17:01:40 +0000

Роспотребнадзор распорядился использовать при приготовлении еды в детских садах и школах только соль, обогащенную йодом. Ранее Минздрав России сообщил о разработке законопроекта, закрепляющего на федеральном уровне обязанность производителей по йодированию всей пищевой поваренной соли. Медики с этими инициативами согласны.

Think We Know What Predicts Weight Regain? Think Again

Thu, 11 Apr 2019 09:48:45 +0000

Sedentary time, eating fast food, and weighing oneself less than weekly were associated with weight regain after Roux-en-Y gastric bypass surgery, a large study has found.
Medscape Medical News

Worrisome Uptick in Elder Abuse Flagged

Thu, 11 Apr 2019 08:40:54 +0000

Violence against older adults is on the rise, according to a report from the US Centers for Disease Control and Prevention, which encourages healthcare providers to be on the lookout for injuries.
Medscape Medical News

Physician Salaries Up in 2019, Report Shows Who Earns the Most

Thu, 11 Apr 2019 07:09:26 +0000

A new Medscape report shows primary care salaries are up 21.5% since 2015 and specialists' are up 20%. This year, 74% of physicians say they perform at least 10 hours of administrative tasks a week.
Medscape Medical News

Натянутая улыбка на работе грозит алкоголизмом

Thu, 11 Apr 2019 11:27:25 +0000

Американские ученые выяснили, что сотрудники, которые заставляют себя улыбаться или пытаются скрыть чувство раздражения перед клиентами, подвержены риску более интенсивного употребления алкоголя после работы.

New Findings Elucidate Potentially Treatable aspects of ME/CFS

Wed, 10 Apr 2019 20:24:38 +0000

Circulatory defects and orthostatic intolerance are common and potentially treatable manifestations of the illness.
Medscape Medical News

Stress-Related Disorders Increase CVD Risk, Study Suggests

Wed, 10 Apr 2019 18:44:52 +0000

Stress-related disorders were linked to an increased risk for cardiovascular disease (CVD), especially during the first year after diagnosis, new data showed.
Medscape Medical News

Barred From Female Patients, Oncologist Sues Medical Board

Wed, 10 Apr 2019 16:53:59 +0000

A Texas oncologist's medical license was restricted and he was barred from seeing female patients after he was charged with sexual assault. So he sued state medical authorities.
Medscape Medical News

Marijuana Edibles May Be More Harmful Than Thought

Wed, 10 Apr 2019 16:55:33 +0000

In a 2015 study, researchers evaluated 75 marijuana edibles and found only 17% accurately labeled, underlining concerns of patients unknowingly getting too much THC.
WebMD Health News

Treatment for PML Shows Promise in Early Study

Wed, 10 Apr 2019 17:00:30 +0000

A possible treatment for this rare and often fatal viral disease of the brain, which occurs in immunosuppressed patients and has no current therapy, has shown promising preliminary results.
Medscape Medical News

GI Symptoms May Herald Mental Illness in Traumatized Kids

Wed, 10 Apr 2019 17:21:23 +0000

Early-life adversity is associated with increased gastrointestinal problems in children that may affect brain development and behavior, new research suggests.
Medscape Medical News

Acupuncture in the ED a Beneficial Non-Opioid Option for Pain

Wed, 10 Apr 2019 16:12:42 +0000

Acupuncture administered in the emergency department is both feasible and beneficial as a non-opioid, non-pharmacologic option for treating patients with less severe pain, new research says.
Medscape Medical News

Novel, 'Non-habit Forming' Medication May Reduce Low Back Pain

Wed, 10 Apr 2019 16:27:19 +0000

Randomized controlled trial findings suggest possible benefits for a pharmaceutical-grade formulation of the neurosteroid pregnenolone as a "non-habit-forming" treatment for chronic low back pain.
Medscape Medical News

High Rates of B Vitamin Deficiency in Teens With Mental Illness

Wed, 10 Apr 2019 16:28:13 +0000

Vitamin B9 and B12 deficiency is a neglected problem in child and, in particular, adolescent psychiatric patients that may have developmental consequences, a large-scale study shows.
Medscape Medical News

DOJ Breaks Up $1.2 Billion Medicare Telemedicine Fraud Ring

Wed, 10 Apr 2019 16:49:25 +0000

Two dozen people, including physicians, were charged in a scheme to sell orders for medically unnecessary orthopedic braces to medical equipment firms.
Medscape Medical News

PBMs Grilled by Senators on How They Profit From Drug Sales

Wed, 10 Apr 2019 15:12:07 +0000

The Senate Finance Committee is looking into the operations of pharmacy benefit managers as HHS seeks to reroute rebates paid to these firms by drugmakers more directly to consumers.
Medscape Medical News

No Protective Effect of Moderate Drinking on Stroke Risk

Wed, 10 Apr 2019 15:28:23 +0000

Blood pressure and stroke risk steadily rise as alcohol intake increases, results from a large, prospective population-based study show.
Medscape Medical News

FDA Takes Action on Bogus Claims for DIY Concussion Devices

Wed, 10 Apr 2019 14:24:28 +0000

The FDA warns that unapproved medical devices and apps are being marketed to the public for concussion assessment without consultation with a healthcare provider.
News Alerts

Gender Pay Gap Persists in Reproductive Endocrinology/Infertility

Wed, 10 Apr 2019 12:47:40 +0000

Although 80% of the Ob/Gyn workforce is female, women working in reproductive endocrinology make significantly less than their male counterparts, despite spending as many hours a week seeing patients.
Medscape Medical News

Should Medical Institutions Return Gifts From Questionable Sources?

Wed, 10 Apr 2019 09:57:26 +0000

Several nonmedical institutions have returned financial gifts from the Sackler family and their company, Purdue Pharma.
Medscape Reader Polls

Could Metformin Before Conception Be the Answer in PCOS?

Wed, 10 Apr 2019 10:12:26 +0000

Metformin ups likelihood of full-term births, reduces late miscarriages in women with PCOS, but doesn't impact gestational diabetes. Study also hints giving drug pre-pregnancy could be beneficial.
Medscape Medical News

«Выбрать, кому предоставить лечение в первую очередь, а кому подождать, всегда не просто»

Wed, 10 Apr 2019 14:40:38 +0000

С появлением современных противовирусных препаратов, гепатит С официально признан излечимым заболеванием. Тем не менее, в России, в условиях дефицита финансирования, он продолжает уносить множество жизней. В том числе, зараженных в медучреждениях детей. Об этом говорили на пресс-конференции, посвященной новым возможностям безинтерфероновой терапии гепатита С у подростков.

Bacterial STIs Increase Among PrEP Users

Wed, 10 Apr 2019 07:28:41 +0000

Bacterial STIs increased in incidence when men who have sex with men began using HIV preexposure prophylaxis (PrEP) medications, a study found.
Medscape Medical News

Средства для отбеливания могут повреждать глубокие слои зубной ткани

Wed, 10 Apr 2019 11:59:34 +0000

Перекись водорода, является действующим веществом многих продуктов для отбеливания зубов, включая полоски, продающиеся в аптеке без рецепта. Исследование показало, что она может плохо влиять на дентин, слой зубной ткани, располагающийся под эмалью.

Ученые: Риск аллергии на вакцины крайне низок

Wed, 10 Apr 2019 11:49:44 +0000

Вероятность аллергической реакции именно на вакцины крайне низкая (1:760 000), но даже при ее наличии аллерголог может обеспечить безопасную вакцинацию.

Students May Feel Safer With Stricter Gun Laws

Wed, 10 Apr 2019 00:32:23 +0000

U.S. adolescents living in states with stricter gun laws may feel safer at school, a survey of high school students suggests.
Reuters Health Information

FDA OKs Romosozumab for Postmenopausal Osteoporosis

Tue, 09 Apr 2019 18:42:41 +0000

Romosozumab should be reserved for women at high risk for fracture who fail other therapies and should be avoided in women with a history of heart attack or stroke.
FDA Approvals

NYC Declares Measles Emergency as Cases Surge Across US

Tue, 09 Apr 2019 18:01:21 +0000

New York City has declared a public health emergency, with mandatory MMR vaccinations in select zip codes in Williamsburg, amid a measles outbreak in the Orthodox Jewish community there.
Medscape Medical News

Abrupt Discontinuation of Opioids Dangerous, FDA Warns

Tue, 09 Apr 2019 18:31:52 +0000

Opioid-dependent patients who suddenly stop the medication or rapidly decrease the dose may suffer serious withdrawal symptoms, uncontrolled pain, and psychological distress, the FDA reports.
Medscape Medical News

Attracting More Medical Students to Neurology

Tue, 09 Apr 2019 16:26:47 +0000

Including a mandatory clinical neurology experience in the medical school curriculum is one of the key actions necessary to help address the shortage of neurologist specialists in the United States, results of a new study suggest.
Medscape Medical News

Acetaminophen Tied to Stroke Risk in Older Adults With Diabetes

Tue, 09 Apr 2019 15:19:46 +0000

Caution urged in interpreting findings, as acetaminophen is still considered safe to use in elderly patients.
Medscape Medical News

Teaching Patients to Regulate Emotions May Ease Chronic Pain

Tue, 09 Apr 2019 15:26:17 +0000

A novel primary care-based program, designed to recalibrate negative emotions associated with chronic pain, shows benefits in older adults with varying levels of cognitive function.
Medscape Medical News

Newly Approved Drug a 'Revolution' for Postpartum Depression

Tue, 09 Apr 2019 14:19:23 +0000

The marked improvement in postpartum depression within 60 hours of intravenous brexanolone infusion is sustained over 30 days, with half of patients still responding, a pooled analysis of three RCTs shows.
Medscape Medical News

ALERTS: Implantable STEMI Detector Trial Misses Primary End Point

Tue, 09 Apr 2019 14:25:32 +0000

Trial results did not meet the primary efficacy end point detecting silent myocardial infarction in high-risk patients, but researchers are not giving up yet.
Medscape Medical News

CDC Clarifies: Okay to Prescribe Opioids for Cancer Pain

Tue, 09 Apr 2019 14:43:00 +0000

The CDC has issued a clarification letter about its Guideline for Prescribing Opioids for Chronic Pain and says it does not want to block appropriate use of the powerful analgesics.
Medscape Medical News

Benzodiazepines Linked to Risk for Spontaneous Abortion

Tue, 09 Apr 2019 13:08:29 +0000

Women who initiate benzodiazepines during pregnancy to treat anxiety may face an increased risk for spontaneous abortion, particularly at higher doses of the drugs, results of a large study suggest.
Medscape Medical News

Patrick Soon-Shiong Sued Over 'Catch and Kill' of Cancer Drug

Tue, 09 Apr 2019 13:48:22 +0000

Sorrento Therapeutics alleges that controversial billionaire Soon-Shiong prevented a bioequivalent of Abraxane from coming to the US market.
Medscape Medical News

Brain Stimulation Rapidly Revives Working Memory in Older Adults

Tue, 09 Apr 2019 11:54:37 +0000

Synchronizing brain rhythms using noninvasive electrical stimulation rapidly improves working memory in older adults.
Medscape Medical News

Disturbed Sleeps Derails Therapy for Complicated Grief

Tue, 09 Apr 2019 11:03:48 +0000

Cognitive grief treatment surpasses antidepressants alone for complicated grief, but sleep disturbances, which are common, can derail treatment.
Medscape Medical News

Maternal Morbidity Greater With Cesareans, Especially in Over 35s

Tue, 09 Apr 2019 11:27:26 +0000

Results raise questions about practices of some obstetricians who perform cesareans because of advanced maternal age, say authors, stressing this birth mode 'is an invasive surgical procedure.'
Medscape Medical News

Витамины и минералы улучшают здоровье только когда мы получаем их из пищи

Tue, 09 Apr 2019 15:57:42 +0000

Витамины и минералы действительно могут улучшать наше здоровье и снижать риск смерти от многих причин. Но получение этих веществ из биологически активных добавок не может помочь даже людям, испытывающим недостаток питательных веществ. Более того, некоторые добавки оказались опасными в высоких дозах.

Live Organ Donor Dangers Debunked by Unlikely Source

Tue, 09 Apr 2019 08:37:54 +0000

With more than 17,000 patients on the wait list for a liver in the United States but only 5000 deceased-donor livers available each year, specialists are grappling with gaps and new ideas to help.
Medscape Medical News

Sleeping Pill Use Linked to Later Increase in BP Meds

Tue, 09 Apr 2019 07:12:04 +0000

The use of sleeping tablets by older hypertensive patients was linked to a subsequent increase in the use of antihypertensive medication in a new study.
Medscape Medical News

Многие женщины не рассказывают о менструальной боли и сильных кровотечениях даже врачу

Tue, 09 Apr 2019 11:16:32 +0000

Многие женщины, страдающие от боли и сильного кровотечения во время менструации, не рассказывают об этом своим семьям или врачам, даже если эти симптомы нарушают повседневную жизнь. Ученые указывают, что вокруг менструальных симптомов существует некоторое табу, которое мешает их лечению.

FDA Clears New Drug-Sparing Option for HIV Infection

Mon, 08 Apr 2019 18:20:33 +0000

The dolutegravir and lamivudine combination (Dovato) is the first once-daily, single-tablet, two-drug regimen for adults with treatment-naive HIV infection.
Medscape Medical News

Signs of Improved CV Mortality After ACA Medicaid Expansion

Mon, 08 Apr 2019 16:36:48 +0000

States that took advantage of the Affordable Care Act's expansion of Medicaid between 2010 and 2016 may have stemmed what had been an overall rise in cardiovascular mortality in the US.
Medscape Medical News

Drug Derived from Botulinum Toxin Curbs Excessive Drooling

Mon, 08 Apr 2019 16:52:06 +0000

IncobotulinumtoxinA provides lasting improvement in chronic sialorrhea due to Parkinson disease and other neurologic disorders, phase 3 data show.
Medscape Medical News

Novel Drug Promising for Life-Threatening Rett Syndrome in Kids

Mon, 08 Apr 2019 17:19:49 +0000

Now under development, trofinetide could eventually fill the critical need for a safe and effective treatment for the life-threatening Rett syndrome in children and teens.
Medscape Medical News

Activated Charcoal Bag Tied to Big Rise in Proper Disposal of Unused Opioids After Surgery

Mon, 08 Apr 2019 15:49:21 +0000

Post-op patients given an activated charcoal bag upon discharge showed close to a four-fold increase in appropriate disposal of unused opioids, researchers say.
Reuters Health Information

81 Women Sue After Hospital Cameras Record Labor Procedures

Mon, 08 Apr 2019 15:51:32 +0000

A San Diego-area hospital says the cameras were installed to catch a drug thief. One woman, who says her emergency Cesarean delivery was recorded, said, 'I have never been so exposed in my life.'
Medscape Medical News

New Nursing Home Patients May Wait to See a Doctor

Mon, 08 Apr 2019 15:12:08 +0000

When Medicare patients are discharged from a hospital to a skilled nursing facility, the time it takes for a doctor or advanced-level practitioner to see them for a first evaluation can vary widely, a new study suggests.
Reuters Health Information

'Excellent' Transplant Outcomes With Hearts Donated After Circulatory Death

Mon, 08 Apr 2019 14:51:26 +0000

Heart transplantation with organs donated after circulatory death (DCD) can yield "excellent" outcomes, researchers from Australia report.
Reuters Health Information

PET Imaging Improves MCI, Dementia Diagnoses, Alters Management

Mon, 08 Apr 2019 15:22:31 +0000

Amyloid PET imaging in patients with suspected mild cognitive impairment or dementia results in more accurate diagnoses and alters patient management, results of a large, longitudinal study show.
Medscape Medical News

No Influence of Dietary, Supplemental Minerals on MS Risk

Mon, 08 Apr 2019 15:32:54 +0000

Potassium, magnesium, calcium, and other minerals neither guard against or promote the risk of multiple sclerosis, new research shows.
Medscape Medical News

Workplace Yoga Can Indeed Lower Employee Stress

Mon, 08 Apr 2019 14:34:07 +0000

People who get to do yoga at work may be less stressed out than their peers who don't, a research review suggests.
Reuters Health Information

Getting Ready for Resistance to First-Gen NTRK Inhibitors

Mon, 08 Apr 2019 14:33:53 +0000

Just a few months ago, larotrectinib was approved for treating any NTRK+ tumor. Already, there are studies in place to address any mutations that emerge with the first-generation TRK-targeted agent.
Medscape Medical News

DTC Telemedicine Linked to More Antibiotics for ARIs

Mon, 08 Apr 2019 12:44:02 +0000

Pediatric direct-to-consumer telemedicine visits resulted in more antibiotic prescriptions and less concordance with prescribing guidelines than in-person visits in a retrospective study.
Medscape Medical News

Entrectinib Approaches Market for NTRK+ Tumors and ROS1+ NSCLC

Mon, 08 Apr 2019 13:19:06 +0000

Data from the clinical development of entrectinib, targeting NTRK and ROS mutations, readies the drug for its approval across tumors with NTRK fusions as well as for advanced NSCLC with ROS1 fusions.
Medscape Medical News

Сахар снижает внимание и способствует усталости

Mon, 08 Apr 2019 18:57:02 +0000

Идея, что сахар может улучшить настроение, повсеместно распространилась в популярной культуре до такой степени, что люди во всем мире потребляют сладкие напитки, чтобы стать более внимательными или бороться с усталостью. Результаты исследования указывают, что такие заявления не имеют оснований – сахар скорее заставит вас чувствовать себя хуже.

Алкогольное повреждение мозга продолжается даже у бросивших пить

Mon, 08 Apr 2019 19:00:43 +0000

Оказалось, что даже через шесть недель "зявязки" у бывших алкоголиков продолжаются разрушительные процессы в головном мозге.

Excess Vitamin D Linked to Kidney Damage

Mon, 08 Apr 2019 11:27:06 +0000

A case study shows that excessive vitamin D intake can cause kidney damage in patients who are not vitamin D deficient; physicians should caution patients about taking over-the-counter supplements.
Medscape Medical News

Better Longer-Term Survival in NSCLC After Nivolumab Response

Mon, 08 Apr 2019 11:08:00 +0000

Previously treated patients with advanced NSCLC who responded to nivolumab had long-term survival that was notably higher than patients who received docetaxel.
Medscape Medical News

With 130/80 HTN Cutoff, Lifetime Risk Exceeds 80 Pct for Black Women and Men, White Men

Mon, 08 Apr 2019 09:54:06 +0000

Lifetime risks for hypertension are high for black men and women and white men under the American Heart Association/American College of Cardiology (AHA/ACC) 2017 guidelines, which reduced the diagnostic threshold for the disorder, researchers say.
Reuters Health Information

No U.S. Labs Follow All Guidelines for 'Cell-Free' Prenatal Testing

Mon, 08 Apr 2019 09:50:23 +0000

Not even one of the commercial labs offering "cell-free" noninvasive prenatal screening for chromosomal disorders is fully following the recommendations published by the American College of Medical Genetics, according to a new report.
Reuters Health Information

Moving Much More, Not Diet, Key to Keeping Off Excess Pounds

Mon, 08 Apr 2019 09:54:50 +0000

'Striking' results show those who maintained weight loss ate roughly the same number of calories as overweight/obese controls but exercised more. Experts wonder what drives them.
Medscape Medical News

Apology Laws Don't Cut Payouts in National Analysis

Mon, 08 Apr 2019 10:10:45 +0000

Authors say the laws don't work because payouts have either been steady or have risen in states with apology laws. A health policy expert argues that lower payouts were never the laws' main intent.
Medscape Medical News

Early Treatment of Vulvovaginal Atrophy May Prevent Distressing Symptoms

Mon, 08 Apr 2019 09:43:50 +0000

Treatment of vulvovaginal atrophy (VVA) in postmenopausal women should start as early as possible and continue as long as required, researchers say.
Reuters Health Information

Surrogates Speed Cancer Drug Approvals, but Only by 11 Months

Mon, 08 Apr 2019 08:57:10 +0000

Is a 12% reduction in time to market worth the uncertainty of overall survival, researchers ask. A commenter says the cost savings and potential benefit to patients and healthcare are worth the risk.
Medscape Medical News

Люди забывают наносить солнцезащитный крем на самые важные участки кожи

Mon, 08 Apr 2019 10:56:41 +0000

Кожа век очень тонкая и сильно подвержена воздействию ультрафиолета и раку кожи, однако «люди не знают, что не покрывали их кремом».

US News Ranks Standout Medical Schools by Specialty

Fri, 05 Apr 2019 20:14:26 +0000

UNC Chapel Hill again is best in primary care; Harvard repeats as best in research. The news site names top schools in eight specialties.
Medscape Medical News

Dozens of Clinics Market Risky Cell Therapies to Treat Eye Disorders

Fri, 05 Apr 2019 17:18:35 +0000

Scores of clinics across the United States directly advertise expensive - but unproven - stem cell therapies to patients with serious eye diseases, often with devastating results, a new study warns.
Reuters Health Information

FDA Warns Lab Against Marketing Tests Linking Genes, Drug Reaction

Fri, 05 Apr 2019 17:12:34 +0000

Inova Genomics is cited for illegally marketing MediMap genetic tests that claim to predict a patient's response to antidepressants and other medications.
News Alerts

Denver May OK Personal Use of 'Magic Mushrooms'

Fri, 05 Apr 2019 17:22:27 +0000

Psychedelic mushrooms could be decriminalized for the first time in more than 50 years in a US city if Denver activists have their way.
WebMD Health News

Fecal Microbiome Signature Detects Cirrhosis in Nonalcoholic Fatty-Liver Disease

Fri, 05 Apr 2019 15:56:14 +0000

A fecal microbiome signature accurately detects cirrhosis in patients with nonalcoholic fatty-liver disease (NAFLD), researchers report.
Reuters Health Information

Drug Company Founder Put 'Profits Over Patients' to Push Opioid -U.S. Prosecutor

Fri, 05 Apr 2019 16:10:29 +0000

The founder of Insys Therapeutics Inc put profits over patients' safety by bribing doctors to prescribe an addictive fentanyl spray, fueling the U.S. opioid epidemic, a federal prosecutor said Thursday at the end of a landmark trial.
Reuters Health Information

Gene Variant Ups Stroke Risk in Childhood-Cancer Survivors Treated With CRT

Fri, 05 Apr 2019 14:57:00 +0000

A common genetic mutation on chromosome 5 is tied to an increased risk of stroke in childhood-cancer survivors who received cranial radiation therapy (CRT), according to a new study.
Reuters Health Information

Digital Breast Tomosynthesis Better for Screening Mammography in Older Women

Fri, 05 Apr 2019 15:02:04 +0000

Digital breast tomosynthesis (DBT) performs better than two-dimensional digital mammography (DM) as screening mammography in women aged 65 years and older, researchers report.
Reuters Health Information

Drugmakers Pay $123 Million to Resolve U.S. Charity Kickback Probe

Fri, 05 Apr 2019 15:20:39 +0000

Three drugmakers will pay $122.6 million to resolve claims they used charities that help cover Medicare patients' out-of-pocket drug costs as a way to pay kickbacks aimed at encouraging the use of their medications, including some expensive ones.
Reuters Health Information

Hospitalized Teens Not Getting Needed Reproductive-Health Care

Fri, 05 Apr 2019 15:26:57 +0000

Healthcare providers are missing numerous opportunities to identify and address the reproductive-health needs of hospitalized teens, a study by U.S. researchers has found.
Reuters Health Information

FDA Clears Intermittent Theta-Burst System for Major Depression

Fri, 05 Apr 2019 15:12:49 +0000

The FDA clearance will let Magstim include intermittent theta-burst stimulation with its Horizon transcranial magnetic stimulation systems for treating major depression, the company announced.
Medscape Medical News

FDA Issues List of 'Safe' Sartan-Containing Meds

Fri, 05 Apr 2019 14:08:26 +0000

The list of 40 products containing angiotensin receptor blockers that have been cleared as nitrosamine-free also notes meds not covered by recalls that the agency is still testing for taint.
News Alerts

Полезный эффект вакцинации против ВПЧ проявляется даже в двадцатилетнем возрасте

Fri, 05 Apr 2019 18:58:23 +0000

Новое исследование демонстрирует ранние преимущества вакцинации против вируса папилломы человека (ВПЧ). Ученые определили, что плановая вакцинация девочек до 13 лет в Шотландии, проводившаяся с 2008 года, привела к резкому снижению количества заболеваний шейки матки к возрасту 20 лет, включая болезни, повышающие риск развития рака

New Tool Bests BMI for Assessing Obesity-Linked Health in Kids

Fri, 05 Apr 2019 10:59:54 +0000

Using body mass index (BMI) only to evaluate the severity of a child's obesity can miss other important health concerns, including mental health problems, a study found.
Medscape Medical News

Contradictory Findings for Diet and Dementia Risk

Fri, 05 Apr 2019 10:14:06 +0000

Contradicting results from several recently-published studies, new research suggests a healthy diet during midlife does not prevent dementia later on.
Medscape Medical News

Biogen SMA Drug Price, Novartis Estimates for Its Treatment Far Too High -U.S. Group

Fri, 05 Apr 2019 09:00:09 +0000

Biogen Inc should slash the price of its spinal muscular atrophy (SMA) drug, and the $4 million to $5 million Novartis has said its experimental gene therapy for the disease is worth is excessive, an independent U.S. organization that reviews the value of medical treatments said on Wednesday.
Reuters Health Information

People Rarely Apply SPF Moisturizer as Thoroughly as Sunscreen

Fri, 05 Apr 2019 08:22:05 +0000

When applying sunscreen, people tend to miss spots on their faces, and a new study suggests this is even more likely when they use SPF moisturizers.
Reuters Health Information

CMS Partners With AAFP on $1M AI Development Contest

Fri, 05 Apr 2019 07:30:17 +0000

Best solutions for predicting admissions and adverse events may be used in new care models; the American Academy of Family Physicians (AAFP) also plans to test AI software to reduce administrative burdens.
Medscape Medical News

Плохое питание убивает больше людей, чем курение

Fri, 05 Apr 2019 12:16:05 +0000

Каждая пятая смерть в мире происходит из-за неправильного питания, утверждается в многолетнем исследовании Global Burden of Disease. По оценкам исследователей, в 2017 году 11 миллионов смертей были связаны с неправильным питанием – 10 миллионов от сердечно-сосудистых заболеваний, 913000 от рака и почти 339000 от диабета 2-го типа.

Умеренные дозы алкоголя не предотвращают инфаркт и инсульт

Fri, 05 Apr 2019 11:32:46 +0000

Умеренные дозы алкоголя не предупреждают развития инфаркта и инсульта, вопреки распространенному мнению. Более того, чем больше человек выпивает, тем больше у него увеличивается риск инсульта.

ITP and B-cell Lymphoma Feature in Latest BSH Guidance

Fri, 05 Apr 2019 04:33:31 +0000

Recommendations on tackling osteoporosis in immune thrombocytopenia and mediastinal B-cell lymphoma management are the latest guidance by the British Society for Haematology in a prolific year.
Medscape News UK

[Essay] Leonardo's contributions to human anatomy

Thu, 04 Apr 2019 23:00:08 +0000

Towards the end of the 15th century, the science of anatomy was set to become popular. However, it lacked visual canons that were appropriate to its nature as a descriptive science. Images used in schools of medicine were basic topographic schemas that accompanied texts dealing with various topics.

[Review] Leonardo da Vinci's studies of the brain

Thu, 04 Apr 2019 23:00:08 +0000

Leonardo da Vinci (1452–1519) contributed to the study of the nervous system. His earliest surviving anatomical drawings (circa 1485–93) included studies of the skull, brain, and cerebral ventricles. These works reflected his efforts to understand medieval psychology, including the localisation of sensory and motor functions to the brain. He was also the first to pith a frog, concluding that piercing the spinal medulla causes immediate death. After a 10-year interval in the early 1500s Leonardo resumed his anatomical studies and developed a method to inject hot wax into the ventricular system, creating a cast that showed the shape and extent of the ventricles.

[Clinical Picture] Watching and waiting in chronic hip pain

Thu, 04 Apr 2019 23:00:08 +0000

An 18-year-old man was referred to our hospital for a planned total hip replacement. He had a long history of reduced mobility and pain in his left hip because of a developmental bone disorder, dysplasia epiphysealis hemimelica (DEH). The teenager was first suspected of having DEH following a consultation when he was 10 years old, but because of his young age, the medical team at the time decided to manage his condition conservatively. They were concerned a more interventionist approach was inappropriate at a young age as he had manageable symptoms and delaying hip replacement surgery would allow him to reach skeletal maturity.

[Articles] Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study

Thu, 04 Apr 2019 23:00:08 +0000

Treatment with direct-acting antivirals is associated with reduced risk for mortality and hepatocellular carcinoma and should be considered in all patients with chronic HCV infection.

[Articles] Monthly sulfadoxine–pyrimethamine versus dihydroartemisinin–piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial

Thu, 04 Apr 2019 23:00:08 +0000

Monthly intermittent preventive treatment with dihydroartemisinin–piperaquine was safe but did not lead to significant improvements in birth outcomes compared with sulfadoxine–pyrimethamine.

[Articles] Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial

Thu, 04 Apr 2019 23:00:08 +0000

Veverimer effectively and safely corrected metabolic acidosis. Longer-term studies are warranted to assess the effects of veverimer on physical functioning and to assess other deleterious consequences of metabolic acidosis including progression of chronic kidney disease and bone health.

[Department of Error] Department of Error

Thu, 04 Apr 2019 23:00:08 +0000

Webster P. Inuit research raises concerns about tuberculosis eradication. Lancet 2019; 393: 1275–76—In this World Report, the tuberculosis incidence in Canada's Inuit people was approximately 300 times higher than in the Canadian-born non-Indigenous population across all of Canada, not only in Ottawa. This correction has been made to the online version as of March 25, 2019.

[Correspondence] Entrance examination misogyny in Japanese medical schools

Thu, 04 Apr 2019 23:00:07 +0000

The proportion of female doctors has been continuously growing worldwide in the past decades, but remains the lowest among the Organization for Economic Co-operation and Development countries in Japan, at 21·0% (median, 44·1%; second lowest, 22·7% in Korea; highest, 74·2% in Latvia).1 Moreover, the proportion of Japanese female doctors younger than age 35 years showed just a slight increase over the past decade (31·3% in 2006 and 33·2% in 2016).

[Correspondence] Sodium bicarbonate for severe metabolic acidaemia – Authors' reply

Thu, 04 Apr 2019 23:00:07 +0000

We report1 that in a severely acidaemic critically ill population, the infusion of 4·2% sodium bicarbonate solution to target a plasma pH equal or above 7·30 is not associated with a decrease in 28-day mortality and the presence of at least one organ failure at day 7 (primary composite outcome). One possible reason, as suggested by Cristian Baicus, is the insufficient power, 28-day mortality being decreased in the sodium bicarbonate group only after multivariate analysis. Interestingly and contrary to what was suggested by Sheldon Magder and Gordan Samoukovic, our trial also shows that sodium bicarbonate infusion is associated with a better 28-day mortality in the prespecified stratum of patients with moderate to severe acute kidney injury.

[Correspondence] Sodium bicarbonate for severe metabolic acidaemia

Thu, 04 Apr 2019 23:00:07 +0000

Even though the primary outcome was inconclusive, the encouraging results of the BICAR-ICU study by Jaber and colleagues1 on the renal secondary outcomes provide some interesting arguments in the debate about the fluids content used in intensive care.

[Correspondence] Sodium bicarbonate for severe metabolic acidaemia

Thu, 04 Apr 2019 23:00:07 +0000

Jaber and colleagues1 report the results of a thoughtfully designed trial examining sodium bicarbonate administration to critically ill adults with acidaemia. We congratulate the authors on this accomplishment and pose two questions.

[Correspondence] Sodium bicarbonate for severe metabolic acidaemia

Thu, 04 Apr 2019 23:00:07 +0000

Jaber and colleagues1 found, as have others,2,3 that infusing sodium bicarbonate in patients with severe acute acidaemia does not improve survival or Sequential Organ Failure Assessment score. Sodium bicarbonate did not even reduce vasopressor use. Similarly, the compound did not improve cardiac contractility in pigs with lactic acidosis.4 The only effect of sodium bicarbonate that Jaber and colleagues found was decreased use of dialysis, which could have clinical value.5 But was dialysis necessary in all cases? In the physical and chemical analysis of acid-base abnormalities developed by Peter Stewart,6,7 the difference in sodium and chlorine concentrations is a crucial determinant of pH and bicarbonite concentration.

[Correspondence] Sodium bicarbonate for severe metabolic acidaemia

Thu, 04 Apr 2019 23:00:07 +0000

We read with great interest the Article by Samir Jaber and colleagues (June 14, 2018, p 31)1 concerning treatment with sodium bicarbonate for patients with severe metabolic acidaemia in the intensive care unit. The conclusion was that sodium bicarbonate had no effect on the primary composite outcome or on the components of this composite outcome, the most important being mortality at 28 days, and there was no mention in the discussion, or in the Comment by Kraut and Madias,2 that the study could have not had enough statistical power.

[Correspondence] Validity of details in databases logging police killings – Authors' reply

Thu, 04 Apr 2019 23:00:07 +0000

Police killings are inaccurately measured in official statistics.1 Citizen-compiled databases such as Mapping Police Violence (MPV) thus offer important public-health surveillance of these events. Although some degree of misclassification of exposure is possible, it is improbable to have substantially affected our estimates or conclusions.2

[Correspondence] Validity of details in databases logging police killings

Thu, 04 Apr 2019 23:00:07 +0000

Jacob Bor and colleagues (July 28, 2018, p 302)1 found that there was a causal relationship between exposure of black Americans to police killings of unarmed black people and deterioration of their mental health. This is an important research endeavour, but we are concerned the methods used in the study could undermine an important message. The authors used data from the Mapping Police Violence (MPV) database. In these data, citizens holding a toy weapon (eg, pellet gun, air rifle) or “alleged to be armed by the police, but multiple independent witnesses maintain the person was unarmed,” are coded as unarmed.

[Correspondence] The cerebral ventricles in Leonardo's anatomical drawings

Thu, 04 Apr 2019 23:00:07 +0000

Facinated with questions about the origin of life, Leonardo da Vinci (1452–1519) was captivated by the brain. The brain was perceived at that time to be the house of the principle of life (ie, the soul was thought to reside at the geometrical centre of the brain). Evidence of the evolution of Leonardo's knowledge about the organisation of the brain can be seen in the comparison of two drawings (figure).

[Correspondence] Leonardo's folio 730 recto: lessons for the medical humanities

Thu, 04 Apr 2019 23:00:07 +0000

2019 marks the 500th anniversary of Leonardo da Vinci's death, inviting us to reflect on the strong relationship between science and the humanities in his work. The fundamental principles of Leonardo's genius have been widely received in many scientific fields1 but not in medical education, in which folio 730 recto of the Codex Atlanticus (figure) could be a valuable tool. The document was ahead of its time, as it contains a core curriculum proposal for the medical humanities that is consistent with the increasing influence of the humanities in medical schools at present.

[Obituary] Leonardo da Vinci

Thu, 04 Apr 2019 23:00:07 +0000

Painter, sculptor, draughtsman, engineer, stage designer, architect, musician, anatomist, naturalist, physicist, astronomer, cartographer, and poet. Born in Vinci, Italy, on April 15, 1452, he died in Amboise, France, on May 2, 1519, aged 67 years.

[Perspectives] Leonardo's philosophical anatomies

Thu, 04 Apr 2019 23:00:07 +0000

Was Leonardo da Vinci an anatomist? This may seem like an unnecessary question, given more than 200 pages of anatomical studies in the UK's Royal Collection at Windsor Castle. However, if we refine the question and ask if Leonardo studied anatomy in the same way as a modern anatomist, the answer becomes more complicated and inherently more rewarding.

[Perspectives] Drawing inspiration from Leonardo

Thu, 04 Apr 2019 23:00:07 +0000

I remember the dismay I felt, aged 16 years, when it seemed I would have to give up art at A level—it clashed with physics. But I loved them both.

[World Report] 2019 Gairdner awards recognise global mental health

Thu, 04 Apr 2019 23:00:07 +0000

Harvard's Vikram Patel receives the 2019 John Dirks Canada Gairdner Global Health Award, a rare win for the field of mental health. Talha Burki reports.

[World Report] Providing care for trans women with HIV/AIDS in Peru

Thu, 04 Apr 2019 23:00:07 +0000

Peru's trans women remain a hard-to-reach population for the treatment of HIV/AIDS but the lack of access to care is, in part, due to widespread discrimination. Barbara Fraser reports from Lima.

[Comment] Offline: Global health has forgotten the Arab World

Thu, 04 Apr 2019 23:00:07 +0000

In the concluding article of a 2014 Lancet Series on Health in the Arab World, Abbas El-Zein and colleagues wrote about “a choice between, on the one hand, regional cooperation and ecological integration for the sake of survival and, on the other hand, war, sectarian divisions, mistrust, and little hope in the future”. 5 years on, that choice has been made. The early years of the 21st century, especially since Sept 11, 2001, have been, in the words of historian Eugene Rogan, “the worst in modern Arab history”.

[Comment] Why and how did Leonardo happen: the Renaissance context

Thu, 04 Apr 2019 23:00:07 +0000

The period between the end of the 14th and 16th centuries, the Renaissance, is generally seen as marking the passage in Europe from the medieval to the beginning of the modern era. Italy was the cradle of the Renaissance, which eventually spread through Europe and was characterised by a flourishing in the arts, literature, politics, religion, philosophy, and science, and a renewed interest in classical Roman and Greek cultures. Many professionals including artists, architects, physicians, and scientists shaped this unique period by advancing a concept of erudition based on innovative enquiry and humanism with the aim of reawakening a link with antiquity while questioning classical ideas.

[Comment] Time to address the plight of the people of northeastern Syria

Thu, 04 Apr 2019 23:00:07 +0000

The health system in the de-facto autonomous region of northeastern Syria, comprising the governorates of Al-Hasakah, Deir ez-Zor, Raqqa, and parts of Aleppo, has been decimated by 8 years of conflict. Although the region's Kurdish-led self-administration has achieved a modicum of stability, with Daesh (ISIS) no longer holding territory, it faces a unique set of challenges, with hundreds of thousands of people in acute need of humanitarian assistance, including tens of thousands of displaced people living in dire conditions in camps and settlements.

[Comment] Direct-acting antiviral treatment for hepatitis C

Thu, 04 Apr 2019 23:00:07 +0000

About 71 million people are chronically infected with the hepatitis C virus (HCV) worldwide.1 Chronic HCV infection causes substantial morbidity and mortality, with complications including cirrhosis, end-stage liver disease, hepatocellular carcinoma, and death.2 These complications have tripled over the past 15 years, and models project they will peak between 2030 and 2035.3 Therapeutic options for chronic HCV infection have evolved over the past 5–7 years, from peginterferon plus ribavirin (associated with suboptimum cure and high treatment-related toxicity) to oral direct-acting antiviral treatment.

[Comment] Beyond birthweight: benefits and risks of preventing malaria in pregnancy

Thu, 04 Apr 2019 23:00:06 +0000

One of the cornerstones of malaria control in sub-Saharan Africa is the administration of intermittent preventive treatment during pregnancy with sulfadoxine–pyrimethamine. In the past few decades, studies have shown that prevention of Plasmodium falciparum infection during pregnancy leads to improved birthweight in infants.1 However, resistance to sulfadoxine–pyrimethamine is now widespread in the region, prompting a search for an alternative drug.

[Comment] Treatment of metabolic acidosis with an intestinal binder

Thu, 04 Apr 2019 23:00:06 +0000

In The Lancet, Donald Wesson and colleagues1 describe the results of their 12-week multicentre, phase 3, double-blind, randomised, placebo-controlled trial of veverimer in patients with metabolic acidosis and chronic kidney disease. Veverimer is a neutral polyamine that becomes protonated once ingested and exhibits selectivity for the chloride anion, effectively removing hydrochloric acid from the contents of the intestinal lumen. The investigators randomly assigned 217 patients (134 [62%] male, mean age 62·9–63·2 years) with an estimated glomerular filtration rate (eGFR) of 20–40 mL/min per 1·73 m2 in a 4:3 ratio to veverimer (n=124) or placebo (n=93); 119 and 89 patients, respectively, completed the trial.

[Editorial] Progress on investigating stillbirths

Thu, 04 Apr 2019 23:00:06 +0000

The UK Government has proposed new powers for coroners to investigate full-term stillbirths, with a consultation period that opened on March 26, 2019. Coroners now only have the power to conduct investigations for babies born showing some signs of life and cannot investigate incidents in which the baby is stillborn, even if there were no warning signs. Proposals would not apply to any baby stillborn before 37 weeks' gestation.

[Editorial] Leonardo's unity

Thu, 04 Apr 2019 23:00:06 +0000

This issue of The Lancet marks 500 years since the death of Leonardo da Vinci on May 2, 1519, and through a range of papers, we hope to convey the breadth of Leonardo's thinking and to illustrate some of his lasting impact on understanding the body, science, and humanity.

[Editorial] China's research renaissance

Thu, 04 Apr 2019 23:00:06 +0000

Leonardo da Vinci, whose quincentenary is marked in this issue of The Lancet, epitomised the Italian renaissance. The renaissance was a time of exceptional intellectual advancement, amid disruptive changes. Change was already underway at early universities, like Padua, which transformed attitudes by codifying the study of medicine. In 1453, when Leonardo was aged 1 year, Constantinople fell to the Ottoman army, marking the end of the Byzantine Empire and the beginning of a new world order with widened horizons.

Adjunctive IV Nitroprusside of No Value in Treatment-Resistant Schizophrenia

Thu, 04 Apr 2019 17:27:07 +0000

Adjunctive intravenous sodium nitroprusside (IV SNP) is not effective for individuals with schizophrenia who have a history of treatment resistance, results of a proof-of-concept clinical trial reveal.
Reuters Health Information

Endoscopic Clip Closure After Large Polyp Resection in Right Colon Reduces Bleeding

Thu, 04 Apr 2019 17:30:22 +0000

Endoscopic clip closure after resection of large sessile polyps in the proximal colon reduced the risk of post-procedure bleeding in a multicenter randomized trial, researchers say.
Reuters Health Information

Laws Banning Driver Texting Tied to Drop in ER Visits for Crash Injuries

Thu, 04 Apr 2019 17:36:11 +0000

States where it's illegal to text while driving may have safer roads, according to a U.S. study that tracked declines in crash-related emergency room visits after these laws took effect.
Reuters Health Information

Ketamine a Panacea for Resistant Depression? Not So Fast

Thu, 04 Apr 2019 17:45:15 +0000

Reports of relapses and suicides are tempering some of the earlier excitement over ketamine's much-needed rapid relief for patients with severe depression.
Medscape Medical News

Umbralisib Shows Promise in Relapsed/Refractory Marginal Zone Lymphoma

Thu, 04 Apr 2019 15:59:47 +0000

Umbralisib, an investigational oral inhibitor of PI3K-delta, has significant activity against relapsed/refractory marginal-zone lymphoma (MZL) and manageable side effects, according to early results from an ongoing phase 2b trial.
Reuters Health Information

U.S. States Sue to Undo Trump Rollback of Healthy School Lunch Rules

Thu, 04 Apr 2019 16:07:25 +0000

Several U.S. states sued the Trump administration on Wednesday to undo its recent decision that allowed fewer whole grains and more sodium in school breakfasts and lunches.
Reuters Health Information

First Human Trial of Universal Flu Vaccine Candidate Underway

Thu, 04 Apr 2019 16:31:30 +0000

The first-in-human trial of a universal influenza vaccine candidate is currently underway at the National Institutes of Health, researchers have announced.
Medscape Medical News

Cannabis, Hemp Seeds Cross-Reactive in Some With Allergies

Thu, 04 Apr 2019 15:02:59 +0000

Hemp seeds and cannabis are cross-reactive in some allergic individuals, a new report on 15 cases shows.
Reuters Health Information

Hypertonic Dextrose Injection Appears Effective for TMJ Dysfunction

Thu, 04 Apr 2019 15:07:16 +0000

Injections of hypertonic dextrose into affected joints may improve jaw pain, function and maximal interincisal opening in patients with temporomandibular joint dysfunction, researchers report.
Reuters Health Information

Higher-Volume TAVR Centers Show Lower Mortality

Thu, 04 Apr 2019 14:58:05 +0000

In the largest study done to date, including more than 90k transfemoral TAVRs, volume still matters.
Medscape Medical News

FDA Confirms Unsafe Levels of Metals in Some Kratom Products

Thu, 04 Apr 2019 15:51:06 +0000

Final laboratory test results support the agency's public warning about the risk of heavy metals in certain kratom products.
News Alerts

Lenalidomide Plus Rituximab Ups Response in Relapsed Indolent Lymphoma

Thu, 04 Apr 2019 14:50:19 +0000

In patients with relapsed or refractory indolent non-Hodgkin lymphoma, adding lenalidomide to rituximab improves response, according to a placebo-controlled trial.
Reuters Health Information

FDA Approves Supersaturated-Oxygen System for PCI of LAD-STEMI

Thu, 04 Apr 2019 14:49:53 +0000

The Therox system, long in development, allows poststenting delivery of oxygen-supersaturated blood to myocardium during evolving STEMI; studies have suggested it can limit infarct size.
FDA Approvals

Cigna Launches Program to Cap Out-of-Pocket Insulin Costs at $25/month

Thu, 04 Apr 2019 13:38:43 +0000

Health insurer Cigna Corp on Wednesday launched a program aimed at ensuring some diabetes patients pay no more than $25 for a 30-day supply of insulin in the wake of heightened public scrutiny over soaring prices of the life-saving drug.
Reuters Health Information

University of Illinois Missed Warning Signs of Research Going Awry

Thu, 04 Apr 2019 12:16:19 +0000

UIC has played down its shortcomings in overseeing the work of a prominent child psychiatrist, but newly obtained documents show that the school acknowledged its lapses to federal officials.
ProPublica

Parathyroid Hormone Replacement Effective, Safe Long Term

Thu, 04 Apr 2019 11:08:06 +0000

A 6-year open-label extension study of recombinant human parathyroid hormone shows efficacy, safety in treating chronic hyperparathyroidism.
Medscape Medical News

Aspiring Doctors Seek Advanced Training in Addiction Medicine

Thu, 04 Apr 2019 11:22:05 +0000

A number of healthcare institutions are offering fellowships to physicians who want postgraduate training in treating substance use disorders with the same precision as other diseases.
Kaiser Health News

Schizophrenia Risk and Insulin Resistance Intrinsically Linked

Thu, 04 Apr 2019 10:13:02 +0000

Schizophrenia patients with insulin resistance show diminished response to antipsychotic medication and may require personalized treatment.
Medscape Medical News

Low-Cal Diet With a Daily Meal Shake May Suit Some T2D Patients

Thu, 04 Apr 2019 10:15:01 +0000

There is some evidence that overweight people with type 2 diabetes might derive some benefit from liquid meal replacements if it fits with their values and preferences, researchers suggest.
Medscape Medical News

Less HF Hospitalization on Dapagliflozin in Diabetes at Any LVEF

Thu, 04 Apr 2019 08:54:20 +0000

Survivals gains were seen in DECLARE-TIMI 58 only in those with low ejection fractions. Preliminary, but it suggests an SGLT2 inhibitor benefit in a range of people with diabetes and heart failure.
Medscape Medical News

Elite Hospitals Plunge Into Unproven Stem Cell Treatments

Thu, 04 Apr 2019 09:30:13 +0000

Critics are concerned about the explosion in controversial stem cell procedures offered by clinics and, increasingly, respected hospitals.
Kaiser Health News

Novel Assay Reveals Optimal Treatment in Rare Blood Disorder

Thu, 04 Apr 2019 07:31:36 +0000

Patients with congenital thrombotic thrombocytopenic purpura respond best to a combination of plasma prophylaxis and anti-platelet therapy, shows a novel shear flow assay devised by UK researchers.
Medscape News UK

12 ситуаций, когда нужно срочно вызывать «Скорую»

Thu, 04 Apr 2019 13:33:52 +0000

Сотрудники Скорой помощи нередко жалуются на неоправданные вызовы, отвлекающие их от работы с действительно экстренными пациентами. Но бывает и обратная ситуация, когда, люди, которым нужна срочная госпитализация, пытаются перетерпеть боль, справиться с тяжелым состоянием сами. И не подозревают, что ситуация критическая и счет, возможно, идет на минуты.

Ученые напомнили о возможных опасностях приема пробиотиков

Thu, 04 Apr 2019 12:40:06 +0000

Ученые высказывают опасения о том, что пробиотики не так безобидны, как кажется, и могут влиять на действие других лекарств. Например, их прием может сделать лечение рака менее эффективным.

Woman Who Feels No Pain May Mean a Major Scientific Gain

Wed, 03 Apr 2019 19:12:38 +0000

Jo Cameron, 71, has never experienced physical pain. Now scientists have discovered the genetic mutation behind her rare "condition" and hope to harness it in future treatments.
Medscape Medical News

Restaurant Dishes Labeled Gluten-Free Often Are Not

Wed, 03 Apr 2019 18:30:32 +0000

For people with celiac disease, even tiny amounts of gluten in foods can cause trouble, and restaurants may be the hardest places to avoid the hidden protein, a U.S. study suggests.
Reuters Health Information

Songwriting May Hit the Right Therapeutic Note in PTSD

Wed, 03 Apr 2019 18:21:53 +0000

A novel songwriting program takes music therapy from passive to active engagement — with significant therapeutic potential in patients with posttraumatic stress disorder, new research suggests.
Medscape Medical News

HCV-Infected Hearts, Lungs Safe With Preemptive Antivirals

Wed, 03 Apr 2019 17:00:05 +0000

Excellent survival and graft function was seen in uninfected organ recipients after a short course of antiviral treatment in a pilot trial. The findings could potentially expand the organ donor pool.
Medscape Medical News

Thai Cave Rescue: Details for Preventing Hypothermia, Panic

Wed, 03 Apr 2019 17:00:33 +0000

The medical team sedated the boys with ketamine to prevent the boys' panic and reduce concerns about arrhythmia or medication-related drops in body temperature.
Medscape Medical News

FDA Chief Wants Release of Medical Device Data Tracking Problems

Wed, 03 Apr 2019 17:07:00 +0000

Scott Gottlieb stated that it's "imperative that all safety information be available to the public." The FDA will release thousands of previously unpublished injury reports tied to medical devices.
Kaiser Health News

US Influenza Activity Dipping but Still High, CDC Reports

Wed, 03 Apr 2019 17:44:04 +0000

Influenza activity fell slightly but "remains relatively high for this time of year," according to the Centers for Disease Control and Prevention.
Medscape Medical News

Dosing Calculations May Be Off in Children With Obesity

Wed, 03 Apr 2019 16:49:57 +0000

Methods for calculating ideal body weight (IBW) are inconsistent in obese children and could lead to sub-therapeutic dosing of medications, according to new research.
Reuters Health Information

Diet Including Olive Oil May Reduce Atherothrombotic Risk

Wed, 03 Apr 2019 15:51:36 +0000

These data, in young, healthy obese individuals, support previous findings suggesting an atherosclerotic and atherothrombotic benefit from the Mediterranean diet, researchers say.
Medscape Medical News

Renal Denervation: Blood Pressure Benefit in New Meta-analysis

Wed, 03 Apr 2019 16:14:24 +0000

A new meta-analysis of six sham-controlled studies of renal sympathetic denervation has shown a significant reduction in blood pressure with the technique.
Medscape Medical News

New Rules Will Ease Patients' Access to EHRs, Senate Panel Says

Wed, 03 Apr 2019 15:42:45 +0000

Sen. Lamar Alexander (R-Tenn.), head of the influential HELP committee, wants to make it easier to share and store detailed medical histories.
Kaiser Health News

Trump Says Vote on Healthcare Can Wait Until After 2020 Election

Wed, 03 Apr 2019 14:40:24 +0000

U.S. President Donald Trump said on Monday he was willing to wait until after the 2020 presidential election to get Congress to vote on a new healthcare plan, giving Republicans time to develop a proposal to replace Obamacare.
Reuters Health Information

FDA Investigating Reports of Seizures After Vaping

Wed, 03 Apr 2019 14:33:52 +0000

Thirty-five cases of seizures following use of e-cigarettes, particularly among young people, have been reported to the FDA since 2010.
News Alerts

Lifestyle Intervention Improves Fertility in Obese Women

Wed, 03 Apr 2019 11:57:44 +0000

Low-intensity, long-duration intervention may be key to improving overall fertility and spontaneous pregnancy rates in women with obesity having difficulty conceiving.
Medscape Medical News

Severe Obesity Raises Particular Travel Health Issues

Wed, 03 Apr 2019 11:40:00 +0000

International travelers who are obese may face difficulties with flights, hotel access and certain leisure activities, say researchers who suggest the travel industry and travel health specialists should address these issues.
Reuters Health Information

What Do You Think of Home Genetic Testing?

Wed, 03 Apr 2019 10:07:57 +0000

Despite potential pitfalls, the home genetic test market is booming.
Medscape Reader Polls

US Lawmakers Hone in on PBM Role in Insulin Prices

Wed, 03 Apr 2019 10:19:14 +0000

A Texas physician-lawmaker pitched an idea at a hearing about having Medicare and Medicaid cover insulin's entire cost. For now, Congress is focused instead on middlemens' part in rising drug prices.
Medscape Medical News

Ученые рассказали, какие стимулирующие вещества люди принимают перед сексом

Wed, 03 Apr 2019 15:35:52 +0000

Мужчины и женщины любой ориентации нередко совмещают секс и наркотики, говорят результаты нового исследования. Часть опрошенных сообщила об употреблении наркотиков для улучшения своего сексуального опыта. Ученые считают, что исследование этого вопроса позволит разработать новые рекомендации, которые помогут обезопасить сексуальную жизнь.

Gilteritinib: 'Paradigm Shift' to Treat FLT3-Mutated AML

Wed, 03 Apr 2019 08:44:37 +0000

The final readout of ADMIRAL shows significantly improved survival and remission rates with gilteritinib vs standard chemotherapy in relapsed/refractory FLT3-mutated AML, ushering in a new standard of care.
Medscape Medical News

ELIMINATE-AF: Edoxaban Viable Alternative to VKA in AF Ablation

Wed, 03 Apr 2019 08:47:35 +0000

Oral anticoagulant edoxaban was as efficacious and safe as a VKA for use in catheter ablation of atrial fibrillation, an exploratory trial shows. The major composite outcome and bleeding were similar.
Medscape Medical News

«Самый вредный стереотип, который мне хочется разбить вдребезги – то, что лимфостаз неизлечим»

Wed, 03 Apr 2019 09:07:25 +0000

Лимфатический отек – серьезное осложнение лечения рака молочной железы, с которым живут до двух миллионов российских пациенток. В самых тяжелых случаях дело может дойти до ампутации. Можно ли не допустить этого осложнения, и какие современные методики позволяют улучшать качество жизни женщин, перенесших операцию на груди, рассказал реконструктивный хирург Владимир Ивашков.

Сон на боку во время беременности снижает риск мертворождения

Wed, 03 Apr 2019 08:46:20 +0000

Количество случаев мертворождения может сильно уменьшиться, если беременные будут спать на боку во время третьего триместра. Таким образом в мире можно было бы спасти около 153000 детей за один год.

Doctors Need to Do Better at Talking to Families About Critically Ill Patients

Tue, 02 Apr 2019 22:42:11 +0000

Doctors' conversations with families about care for critically ill patients often fail to address patients' values and preferences, according to a study that suggests there's plenty of room for improvements in communication.
Reuters Health Information

"Chemsex" Risk Messages Should Target All, Survey Suggests

Tue, 02 Apr 2019 22:33:08 +0000

Combining sex and drugs is common among all genders and sexual orientations, with people in Britain more likely to engage in the practice than Americans, Australians or other Europeans, according to a global survey.
Reuters Health Information

Telehealth, Urgent Care, Retail Clinics Getting More Popular

Tue, 02 Apr 2019 17:55:00 +0000

But while these alternative forms of healthcare access keep growing, they still represent a small percentage of overall healthcare use, a new survey shows.
Medscape Medical News

Immunosuppressant May Extend Ketamine's Antidepressant Effects

Tue, 02 Apr 2019 17:57:11 +0000

While exploring the immunosuppressant rapamycin and its potential to block the antidepressant effects of ketamine, researchers discovered the drug may actually prolong ketamine's efficacy.
Medscape Medical News

FDA OKs Reintroduction of Tegaserod for IBS-C in Women Under 65

Tue, 02 Apr 2019 17:00:21 +0000

The FDA will allow tegaserod back on the market after an advisory committee recommended its use in women without a history of CV ischemic disease.
FDA Approvals

Bystander Hands-Only CPR Improves Survival

Tue, 02 Apr 2019 17:01:03 +0000

New findings support continuous endorsement of compression-only CPR as an option in cardiopulmonary resuscitation guidelines.
Medscape Medical News

Alirocumab Lp(a) Effects Claim Share of Credit for Benefit in ACS

Tue, 02 Apr 2019 16:32:28 +0000

Reduction in high lipoprotein(a) levels on the PCSK9 inhibitor accounted for a whopping 27% of its clinical value in ODYSSEY Outcomes, supporting Lp(a) as a treatment target, researchers say.
Medscape Medical News

Three Suicides Tied to School Gun Violence: Experts Speak Out

Tue, 02 Apr 2019 14:10:16 +0000

In the wake of three recent suicides linked to mass school shootings, experts are speaking about suicide prevention and the role the media can play.
Medscape Medical News

Virtual Realty App Helps Calm Fear of Heights

Tue, 02 Apr 2019 14:19:52 +0000

An inexpensive self-guided virtual reality app may help patients with acrophobia obtain low-cost and effective help.
Medscape Medical News

Один час бодрого движения в неделю снижает риск инвалидности на 85%

Tue, 02 Apr 2019 19:40:19 +0000

Всего один час в неделю быстрой ходьбы предотвращает инвалидность у пожилых людей с остеоартритом. По данным ВОЗ, более 40% пожилых людей страдают остеоартритом, а приблизительно у двух из пяти человек с артритом (особенно это касается суставов нижних конечностей) развиваются ограничения в связи с инвалидностью инвалидности.

Testosterone May Underlie Rare Blindness Condition in Women

Tue, 02 Apr 2019 12:13:33 +0000

Idiopathic intracranial hypertension, a condition which can lead to blindness and primarily affects obese women, may be the result of increased testosterone levels in the blood and CSF, say UK researchers.
Medscape Medical News

Killed by Cholera, Yemeni Doctor Knew He Was Fighting 'Disastrous' Epidemic

Tue, 02 Apr 2019 11:48:24 +0000

Yemeni doctor Mohammed Abdul-Mughni described the surge in cholera cases he was treating as "disastrous" in a country battered by years of war and short of medical staff.
Reuters Health Information

Myeloma Patients Could Self-Administer Bortezomib at Home

Tue, 02 Apr 2019 10:54:44 +0000

Multiple myeloma patients or even their relatives can be taught to safely self-administer bortezomib at home, reducing both the time they spend at the clinic and resource use, say UK researchers.
Medscape News UK

DART: Success Story in High-Grade Neuroendocrine Carcinomas

Tue, 02 Apr 2019 11:20:52 +0000

Patients with high-grade neuroendocrine carcinomas benefit from dual checkpoint inhibition with ipilimumab and nivolumab after single-agent checkpoint inhibition has failed. Is dual checkpoint blockade ready for prime time?
Medscape Medical News

Local Leaders Back Narcan to Stop Overdose Deaths

Tue, 02 Apr 2019 10:11:58 +0000

A surge in opioid overdose deaths prompted 49 states and the District of Columbia to offer Narcan without a prescription. CDC data showed that nearly 48,000 people died from opioid overdose in 2017.
WebMD Health News

Safe and Cheap Metformin Prevents Type 2 Diabetes Over 15 Years

Tue, 02 Apr 2019 10:23:57 +0000

In long-term follow-up, Diabetes Prevention Program participants randomized to metformin during the trial continue to have lower rates of developing type 2 diabetes.
Medscape Medical News

Flash-Mob Audit Shows Ig Overused in Immune Thrombocytopenia

Tue, 02 Apr 2019 08:58:00 +0000

A novel form of audit that pooled data from a large number of centres over a short period of time has revealed that many UK immune thrombocytopenia patients are not receiving recommended therapy.
Medscape News UK

Rituximab Fails to Improve Symptoms in ME/CFS

Tue, 02 Apr 2019 08:07:24 +0000

New findings in treating myalgic encephalomyselitis/chronic fatigue syndrome (ME/CFS) contradict previous observations and preliminary trial results; illness heterogeneity was cited as a research challenge.
Medscape Medical News

Ticagrelor Alone After PCI: A Strategy Gaining Momentum

Tue, 02 Apr 2019 08:48:25 +0000

GLASSY, a new subanalysis of the GLOBAL LEADERS trial, provides more promising data on the strategy of dropping aspirin after a short period of dual antiplatelet therapy.
Medscape Medical News

Иммунодефициты, мигранты и антипрививочники: что продолжает подпитывать туберкулез в России

Tue, 02 Apr 2019 14:05:20 +0000

Поставленная в проекте правительства России и ВОЗ задача ликвидировать туберкулез в нашей стране в ближайшие 15 лет – реальна, но само по себе это не произойдет. Нужны четкая организация скрининга и лечения, грамотное распределение средств на лекарства. Об этом говорили участники VII Всероссийской конференции, посвященной профилактике и лечению туберкулеза у детей и подростков.

Для поддержания нормального веса после похудения упражнения важнее диеты

Tue, 02 Apr 2019 11:46:41 +0000

Многие знают, что похудеть проще, чем поддерживать нормальный вес после этого. Ученые попытались разобраться, что играет решающую роль в сохранении желаемой массы тела, и теоретически обосновать это.

Genome Sequencing Shows Clinical Promise in AML and ALL

Tue, 02 Apr 2019 04:36:49 +0000

Whole genome sequencing could soon be used clinically to better characterise tumour profiles in leukaemia patients, potentially improving genomic stratification and therapy choices, say UK scientists.
Medscape News UK

Fresenius Medical Care to Pay $231 Mln to Resolve Criminal, Civil Foreign Bribery Charges

Mon, 01 Apr 2019 19:51:05 +0000

Germany-based dialysis clinic operator Fresenius Medical Care AG will pay about $231 million to resolve criminal and civil allegations that the company paid bribes to public health and government officials in several countries to win or retain business, the U.S. Justice Department said on Friday.
Reuters Health Information

Congo Registers Record 15 New Ebola Cases in One Day

Mon, 01 Apr 2019 19:46:35 +0000

Democratic Republic of Congo on Friday recorded 15 new confirmed cases of Ebola, the biggest one-day rise since the current outbreak was declared last August, the health ministry said.
Reuters Health Information

US Measles Cases at Second-Highest Since Elimination in 2000

Mon, 01 Apr 2019 18:11:23 +0000

The number of individual measles cases is at its second highest in the United States since its elimination in 2000, according to the latest data from the Centers for Disease Control and Prevention.
Medscape Medical News

FDA Approves Letairis (Ambrisentan) Generics for PAH

Mon, 01 Apr 2019 17:19:04 +0000

The agency also approved two shared system risk evaluation and mitigation strategy programs for ambrisentan — Ambrisentan REMS (formerly Letairis REMS) and PS-Ambrisentan REMS.
FDA Approvals

FDA OKs Duaklir Fixed-Dose Combination Inhaler for COPD

Mon, 01 Apr 2019 17:21:00 +0000

Duaklir combines aclidinium bromide and formoterol fumarate and is administered twice daily via a breath-actuated inhaler for maintenance treatment of COPD.
FDA Approvals

ED Discharge, Transfer Rates Tied to Patients' Ability to Pay

Mon, 01 Apr 2019 16:36:37 +0000

Uninsured patients and Medicaid beneficiaries were more likely to be discharged or transferred from an emergency department (ED) than privately insured patients, a study found.
Medscape Medical News

Physicians' Understanding of Disability Law Lacking

Mon, 01 Apr 2019 16:50:29 +0000

Interviews with physicians in multiple specialties turned up gaps in their understanding of the mandates of the American With Disabilities Act, authors of a new study report.
Medscape Medical News

International Red Cross Says It Will Channel Aid to Venezuela

Mon, 01 Apr 2019 15:26:08 +0000

The International Federation of the Red Cross and Red Crescent Societies said on Friday it was prepared to channel humanitarian aid to Venezuela through an operation that could be similar to one in Syria, potentially helping ease chronic hunger and disease in the South American nation.
Reuters Health Information

Parenteral-Opioid Shortage Linked to Worse Pain Control in Palliative-Care Patients

Mon, 01 Apr 2019 13:59:06 +0000

Patterns of opioid prescribing in palliative care changed significantly after the parenteral-opioid shortage was announced, and patients were less likely to achieve clinically improved pain, according to new findings.
Reuters Health Information

Noninvasive Brain Stimulation Effective in Resistant Depression

Mon, 01 Apr 2019 13:59:03 +0000

Patients with major depression who don't respond to psychotherapy may benefit from nonsurgical brain stimulation, although novel modalities may be less effective.
Medscape Medical News

Genetic Validation for New LDL Cholesterol-Lowering Target

Mon, 01 Apr 2019 14:42:40 +0000

ATP citrate lyase inhibitors such as bempedoic acid lower LDL cholesterol by the same mechanism of action as statins and may provide similar or perhaps additive cardiovascular protection.
Medscape Medical News

Enucleation Might Be Better Option for Men With Benign Prostatic Hyperplasia

Mon, 01 Apr 2019 13:20:56 +0000

Enucleation might be a better option than resection of the prostate for men with benign prostatic hyperplasia (BPH), according to a new meta-analysis.
Reuters Health Information

Weight Gain, Blood Pressure Rise Seen With JAK Inhibitor Therapy

Mon, 01 Apr 2019 13:27:33 +0000

Pharmacologic inhibition of Janus kinases (JAK) 1 and 2 is associated with significant weight gain and increased systolic blood pressure, according to a review of patients treated with the JAK1/2 inhibitor ruxolitinib.
Reuters Health Information

Dana-Farber Opens First Center Devoted to Lynch Syndrome

Mon, 01 Apr 2019 12:57:12 +0000

The new center will provide genetic testing, coordinated care, and research for individuals with Lynch syndrome.
Medscape Medical News

'Radiomics' Predicts Chemo Response in NSCLC

Mon, 01 Apr 2019 13:02:48 +0000

Radiomic features on baseline CT scans may be able to predict if patients with NSCLC will respond to chemotherapy.
Medscape Medical News

Mesothelin CAR T Cells: First Success Story in Solid Cancers

Mon, 01 Apr 2019 12:15:17 +0000

Results from a phase 1 study show antitumor activity and no sign of major toxicity and herald the first success story of CAR T-cell therapy in solid tumors.
Medscape Medical News

Don't Neglect the Man: Sperm Damage Clues to Recurrent Miscarriage

Mon, 01 Apr 2019 10:23:13 +0000

Men whose partners had experienced recurrent pregnancy loss were four-times more likely to have indicators of DNA damage to their sperm than males of control couples.
Medscape Medical News

Combination Therapy for PTSD Provides No Added Benefit

Mon, 01 Apr 2019 10:46:05 +0000

In the head-to-head PROGRESS trial, there were no significant differences in PTSD outcomes at 24 weeks for trauma-focused psychotherapy plus sertraline vs either treatment alone.
Medscape Medical News

Кесарево сечение особенно опасно для женщин старше 35 лет

Mon, 01 Apr 2019 15:39:26 +0000

Кесарево сечение связано с повышенным риском тяжелых осложнений у рожениц по сравнению с естественными родами, особенно у женщин в возрасте 35 лет и старше. По мнению авторов, результаты указывают врачам и акушерам на необходимость пересмотреть практики, при которой они предпочитают делать кесарево роженицам старше 35 лет, предполагая, что для них это последняя беременность.

Регулярные ночные походы в туалет могут быть признаком гипертонии

Mon, 01 Apr 2019 15:45:32 +0000

Ученые обнаружили, что вставание по ночам, чтобы помочиться, связано с 40%-ным увеличением шансов диагноза гипертонию. И чем больше посещений туалета, тем выше ее риск.

Approaches to Negotiate With Disgruntled Patients, Families

Mon, 01 Apr 2019 08:49:35 +0000

Patients who disagree with a care provider might opt for medically inappropriate treatment or make choices against medical advice, but physicians can intervene to improve outcomes.
Medscape Medical News

Кофе и алкоголь оказались главными пусковыми факторами мерцательной аритмии

Mon, 01 Apr 2019 11:27:46 +0000

Алкоголь вызывал приступ аритмии хотя бы иногда у 35% пациентов с фибрилляцией предсердий, употребление кофе - у 28%, физические упражнения - у 23% и недосыпание - у 21%.

Higher Calcium Intake Tied to Slower AMD Progression

Fri, 29 Mar 2019 20:44:02 +0000

Higher levels of dietary and supplementary calcium intake are associated with a lower risk of progression to late age-related macular degeneration (AMD), according to a secondary analysis of data from a large trial.
Reuters Health Information

Female Radiation Oncologists Earn Less Than Male Peers

Fri, 29 Mar 2019 20:42:58 +0000

Female radiation oncologists collect less in Medicare reimbursement dollars than their male counterparts, even when they see similar numbers of patients, according to a new study.
Reuters Health Information

Venezuelans Facing 'unprecedented Challenges,' Many Need Aid -internal U.N. Report

Fri, 29 Mar 2019 20:38:38 +0000

The United Nations estimates that about a quarter of Venezuelans are in need of humanitarian assistance, according to an internal U.N. report seen by Reuters on Thursday that paints a dire picture of millions of people lacking food and basic services.
Reuters Health Information

Frailty Before Surgery Tied to More Complications, Higher Costs

Fri, 29 Mar 2019 20:39:54 +0000

Patients who are frail before surgery are more likely to have serious complications afterward and increased costs of care, suggesting that frailty should be factored into risk calculations before surgery, researchers say.
Reuters Health Information

Dermatologists and Pharmacists Have Differing Views of Topical Steroids

Fri, 29 Mar 2019 20:39:18 +0000

When it comes to prescriptions for corticosteroid creams, your dermatologist and your pharmacist may not always be on the same page, a new study suggests.
Reuters Health Information

FDA Approves Cladribine (Mavenclad) for Relapsing MS

Fri, 29 Mar 2019 19:21:10 +0000

The US Food and Drug Administration today approved cladribine for treatment of patients with relapsing multiple sclerosis who have had insufficient response to other agents.
FDA Approvals

Arrest Made in the Murder of Child Psychiatrist

Fri, 29 Mar 2019 18:32:43 +0000

The Las Vegas Metropolitan Police have arrested a suspect in the death of a child and adolescent psychiatrist who was found in the trunk of his car on March 7.
Medscape Medical News

EU Panel Backs First Gene Therapy for Beta Thalassemia

Fri, 29 Mar 2019 17:09:18 +0000

Zynteglo is for patients 12 years and older who do not have a β0/β0 genotype, need regular blood transfusions to manage their disease, and have no matching donor for a stem cell transplant.
International Approvals

Advanced Imaging May Reveal Onset of Cognitive Impairment

Fri, 29 Mar 2019 17:32:50 +0000

Using advanced MRI technology that shows nuances in neurotransmitter levels, researchers detected differences in brain regions associated with cognitive function.
Medscape Medical News

PIONEER-HF: In ADHF, Early ARNI Seems Key to Best Clinical Gains

Fri, 29 Mar 2019 15:58:31 +0000

Failure to start therapy in hospital is a 'lost opportunity,' say researchers from evidence that such early sacubitril/valsartan bested enalapril more in the earliest weeks after discharge than later.
Medscape Medical News

Telemedicine Relieves Night Gaps, Specialist Shortages

Fri, 29 Mar 2019 16:25:55 +0000

The benefits of telemedicine, for both hospitals and physicians, extend beyond the medical realm, experts explain.
Medscape Medical News

New Studies Give Bempedoic Acid a Bump as Lipid-Lowering Agent

Fri, 29 Mar 2019 16:33:49 +0000

Reductions in LDL cholesterol were modest when added to statins, but observers say the investigational oral drug may serve a role as an add-on therapy.
Medscape Medical News

REDUCE-IT: High-Dose EPA Also Reduces Subsequent Events

Fri, 29 Mar 2019 14:57:23 +0000

As well as showing a large reduction in first ischemic events, the high dose purified form of eicosapentaenoic acid (EPA) was also associated with reductions in subsequent and total events.
Medscape Medical News

Изменение климата увеличило заболеваемость поллинозами

Fri, 29 Mar 2019 17:59:32 +0000

Изменение климата, связанное с деятельностью человека, влияет на календарь природы, в том числе на время начала весны и цветения растений. Новое исследование указывает, что это приводит к увеличению заболеваемости сезонными аллергиями.

Скольким сигаретам равняется бутылка вина? Ученые подсчитали канцерогенный потенциал алкоголя

Fri, 29 Mar 2019 18:05:18 +0000

Ученые подсчитали, что выпивание трех бутылок вина можно приравнять к выкуриванию восьми сигарет в день для мужчин и 23 - для женщин. Общепризнанная связь между раком и табаком помогает наглядно продемонстрировать связь между употреблением алкоголя и раком, а также повысить осведомленность о связанных с алкоголем рисках.

Pregnancy Outcomes 'Very Good' After Stem Cell Transplant

Fri, 29 Mar 2019 11:15:37 +0000

Fertility preservation techniques should be offered to women undergoing stem cell transplant as their chances of a good pregnancy outcome after HSCT are very high, say European experts.
Medscape Medical News

Air Pollution Linked to Psychosis in Urban-Dwelling Teens

Fri, 29 Mar 2019 11:18:44 +0000

Air pollution is known to be associated with an array of physical illnesses. This study found that it is also associated with high levels of psychosis in urban adolescents.
Medscape Medical News

[The Lancet Commissions] Building a tuberculosis-free world: The Lancet Commission on tuberculosis

Fri, 29 Mar 2019 00:00:08 +0000

Tuberculosis can be treated, prevented, and cured. Rapid, sustained declines in tuberculosis deaths in many countries during the past 50 years provide compelling evidence that ending the pandemic is feasible. Yet this disease—which has plagued humanity since before recorded history and has killed hundreds of millions of people over the past two centuries—remains a relentless scourge. In 2017, 1·6 million people died from tuberculosis, including 300 000 people with HIV, representing more deaths than any other infectious disease.

[Clinical Picture] Facial vein pulsation in severe tricuspid regurgitation

Fri, 29 Mar 2019 00:00:08 +0000

A 53-year-old man presented to our hospital with a 1-month history of dizziness and episodes of hypotension during his outpatient haemodialysis sessions. In addition to end-stage renal disease, the patient had a history of a large anterior myocardial infarction and subsequent percutaneous coronary interventions with stent placement; this had resulted in an ischaemic cardiomyopathy, which had required the implantation of a left ventricular assist device 5 years before this admission. On examination, the patient had a distended jugular vein, a pulsatile liver, and prominent, pulsating facial veins (figure, video 1).

[Articles] Scaling up prevention and treatment towards the elimination of hepatitis C: a global mathematical model

Fri, 29 Mar 2019 00:00:08 +0000

Further improvements in blood safety and infection control, expansion or creation of PWID harm reduction services, and extensive screening for HCV with concomitant treatment for all are necessary to reduce the burden of HCV. These findings should inform the ongoing global action to eliminate the HCV epidemic.

[Articles] Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial

Fri, 29 Mar 2019 00:00:08 +0000

Frozen single blastocyst transfer resulted in a higher singleton livebirth rate than did fresh single blastocyst transfer in ovulatory women with good prognosis. The increased risk of pre-eclampsia after frozen blastocyst transfer warrants further studies.

[Articles] Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial

Fri, 29 Mar 2019 00:00:08 +0000

OAGB is not inferior to RYGB regarding weight loss and metabolic improvement at 2 years. Higher incidences of diarrhoea, steatorrhoea, and nutritional adverse events were observed with a 200 cm biliopancreatic limb OAGB, suggesting a malabsorptive effect.

[Department of Error] Department of Error

Fri, 29 Mar 2019 00:00:08 +0000

Robert M, Espalieu P, Pelascini E, et al. Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial. Lancet 2019; 393: 1299–309—In this Article (published online first on March 6, 2019), affiliations for Maud Robert, Robert Caiazzo, François Pattou, and Emmanuel Disse have been updated. These corrections have been made to the online version as of March 28, 2019, and the printed version is correct.

[Department of Error] Department of Error

Fri, 29 Mar 2019 00:00:08 +0000

Hamada H, Suzuki H, Onouchi Y, et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 2019; 393: 1128–37—The webappendix of this Article has been corrected as of March 28, 2019.

[Correspondence] The West Nile virus epidemic—occupational insight

Fri, 29 Mar 2019 00:00:08 +0000

We read with interest the World Report by Talha Burki (Sep 22, 2018, p 1000)1 about the sudden rise in the number of cases of West Nile virus across Europe in 2018. We have concerns, however, that the current epidemiological surveillance systems in the report do not provide a complete overview of the situation. In our daily work as occupational doctors, outdoor workers often present with flu-like symptoms outside the flu season.

[Correspondence] A lesson from classic British literature

Fri, 29 Mar 2019 00:00:08 +0000

In The Mill on the Floss,1 George Eliot wrote “But the immediate presence of this disgrace was so much keener an experience to Tom than the worst form of apprehension, that he felt at this moment as if his real trouble had only just begun: it was a touch on the irritated nerve compared with its spontaneous dull aching.”

[Correspondence] UK Biobank, big data, and the consequences of non-representativeness

Fri, 29 Mar 2019 00:00:08 +0000

UK Biobank is an unparalleled resource of extensive health information from 500 000 individuals and with more than 400 peer-reviewed publications to date. The sampling population is volunteer-based and is not representative of the UK population.1 Investigators state that although the estimates of prevalence and incidence should be interpreted with caution, valid measures of association and estimates of causal effect can be more readily interpreted as they do “not require participants to be representative of the population at large”.

[Correspondence] Urinary sodium excretion measures and health outcomes – Authors' reply

Fri, 29 Mar 2019 00:00:08 +0000

24 h urine collection is a reference method, rather than the gold standard for measuring sodium intake. A key test of whether different measures of sodium intake are valid is to compare each measure with an independent biomarker, such as blood pressure (BP)—an association upon which current recommendations for reducing sodium intake are based. Large epidemiological studies with 24 h urine collections have shown a weak1 or no2,3 association between 24 h sodium excretion and BP, but several studies that use early-morning fasting urine to estimate sodium intake (with adequate methods—namely the appropriate formula for fasting urine and correct timing of fasting urine collection immediately after a proper 24 h urine collection) show stronger associations with BP than 24 h urine collections,4,5 similar to the 2·42 mm Hg reduction in systolic BP per 1 g lowering of sodium consumption observed in randomised trials.

[Correspondence] Urinary sodium excretion measures and health outcomes

Fri, 29 Mar 2019 00:00:08 +0000

Franz Messerli and colleagues1 discuss the Article by Andrew Mente and colleagues2 about salt, blood pressure, and cardiovascular outcomes, asking the rhetorical question of whether it is “bad science”. We posit that the 50-year-old controversy on salt and cardiovascular morbidity (uniform benefit of salt reduction versus harmful effects for some at very low salt intake—ie, the J curve association) is an issue of no accurate data on salt intake instead.

[Correspondence] Urinary sodium excretion measures and health outcomes

Fri, 29 Mar 2019 00:00:08 +0000

The US recommendation for sodium intake is less than 2·3 g/day for healthy individuals and less than 1·5 g/day for those at risk of cardiovascular disease.1 In 2013, the US National Academy of Medicine concluded that insufficient evidence was available to support such a recommendation. The question remains of whether existing data provide compelling evidence that these guidelines are feasible and will confer health benefit. The recent report by Mente and colleagues2 adds to the literature challenging the long-standing presumption of health benefits.

[Correspondence] Urinary sodium excretion measures and health outcomes

Fri, 29 Mar 2019 00:00:08 +0000

In their analysis of the Prospective Urban Rural Epidemiology (PURE) study, Andrew Mente and colleagues1 investigated the association between sodium intake and cardiovascular disease. However, the authors seem to have ignored new evidence showing that sodium excretion might not necessarily reflect sodium intake.

[Correspondence] Urinary sodium excretion measures and health outcomes

Fri, 29 Mar 2019 00:00:07 +0000

We were disappointed to see yet another re-analysis, by Andrew Mente and colleagues (Aug 11, 2018, p 496),1 of the Prospective Urban Rural Epidemiology (PURE) study on salt, despite its many flaws. Mente and colleagues claimed that reducing salt is only justified in countries where intake is greater than 12·5 g/day, challenging WHO's recommendation to reduce salt intake to less than 5 g/day. These conclusions are not valid because of the inaccurate estimation of salt intake from spot urine using the Kawasaki formula, which has been repeatedly shown to be unreliable and systematically biased.

[Perspectives] Picturing health: it's time to act on tuberculosis

Fri, 29 Mar 2019 00:00:07 +0000

Tuberculosis is the world's most deadly infectious disease. Every year, an estimated 1·6 million people die from tuberculosis and 10 million are infected with the disease, with about 3·6 million people undiagnosed or detected but not reported. Case finding and contact tracing are huge challenges. Many people worldwide do not have access to testing or treatment, especially for multidrug-resistant tuberculosis. The theme of 2019 World Tuberculosis Day is “It's Time”. As Tereza Kasaeva, Director of WHO's Global Tuberculosis Programme, told me: “It's Time, is an urgent call to world leaders and all stakeholders to keep the promises made.

[Perspectives] Christine Sekaggya-Wiltshire: prizewinner in HIV–tuberculosis research

Fri, 29 Mar 2019 00:00:07 +0000

If Christine Sekaggya-Wiltshire, a clinical scientist who leads the tuberculosis and HIV clinic at the Infectious Diseases Institute (IDI) at Makerere University, Kampala, Uganda, were asked to define her research, she could surely do no better than quote one of her mentors, Yukari Manabe: “Christine is doing things that are locally relevant to Uganda, but also have international significance”. A few years ago Manabe, Associate Director of Global Health Research and Innovation in the Center for Global Health at Johns Hopkins University School of Medicine in Bethesda, MD, USA, was working at the IDI.

[Perspectives] Nandita Venkatesan: a voice of hope for tuberculosis survivors

Fri, 29 Mar 2019 00:00:07 +0000

“If you don't listen to someone's first-hand suffering you're not going to know how it feels to suffer all this pain”, says Nandita Venkatesan. She is adamant “it's high time” governments listen and take into account the views of people affected by tuberculosis. As a tuberculosis survivor, Venkatesan, a journalist and a patients' rights advocate, speaks with passion about the pain, the stigma, the inequity, and challenges faced by tuberculosis patients and survivors.

[World Report] Inuit research raises concerns about tuberculosis eradication

Fri, 29 Mar 2019 00:00:07 +0000

Although Canada is on track to meet the eradication goals for tuberculosis set by the high-level meeting, Indigenous communities are still disproportionately affected. Paul Webster reports.

[Comment] Offline: Brexit and Europe—taking the long view

Fri, 29 Mar 2019 00:00:07 +0000

“This England—is it worth fighting for?” The question hangs over Kate Atkinson's immensely successful 2018 novel, Transcription. Although not ostensibly about Brexit, Atkinson's subject is idealism and identity, forces that have shaped, many might say distorted, Britain's present sense of self. Most doctors, public health practitioners, and medical scientists oppose Brexit. Today, they—we—see a nation shamed by humiliation, an erosion of national confidence, and the loss of global reputation. And despair—despair at the partisan manipulation of public opinion, despair at the violent divisiveness of political debate, despair at a growing constitutional emergency.

[Comment] Horizon Europe: towards a European agenda for global health research and innovation

Fri, 29 Mar 2019 00:00:07 +0000

The European Commission (EC) has published its plans for Horizon Europe.1 Building on the success of Horizon 2020,2 Horizon Europe is a €100 billion research and innovation programme that provides the strategic underpinning for the next decade of scientific and technological progress in the European Union (EU). The proposal aims to “boost innovation, capacity, competitiveness and jobs; deliver on citizens priorities; and sustain European values”.1 This plan, which will be implemented through three pillars, provides an opportunity to improve the EC's scientific impact within Europe and extend its global reach.

[Comment] India's leadership to end tuberculosis

Fri, 29 Mar 2019 00:00:07 +0000

A quarter of a century since WHO declared tuberculosis an emergency, tuberculosis still kills more people than any other infectious disease. It is time for leadership, actions, and innovations. Tuberculosis needs the attention of world leaders and high-level decision makers to dramatically accelerate progress to achieve the target of ending tuberculosis under the Sustainable Development Goals (SDGs). The UN General Assembly High-Level Political Declaration in September, 2018, made ending tuberculosis a global priority.

[Comment] Building a tuberculosis-free world on a foundation of universal health coverage

Fri, 29 Mar 2019 00:00:07 +0000

It is a sad indictment of our unequal world that in 2019 we need a Lancet Commission on building a tuberculosis-free world.1 As the authors of this excellent Commission highlight in their first sentence: “tuberculosis can be treated, prevented, and cured”. However, despite progress in some countries, which shows the epidemic can be beaten, this ancient disease continues to kill more people than any other infectious disease—as reported in the Commission, a staggering 1·6 million men, women, and children in 2017.

[Comment] Time to bring tuberculosis out of the shadows

Fri, 29 Mar 2019 00:00:07 +0000

“Tuberculosis is one of the world's most neglected health crises. In spite of its alarming danger, surprisingly little action has been taken to address the TB [tuberculosis] epidemic. TB has been a low priority on the world's health agenda. Every day, I ask why this situation is allowed to continue…Can we really believe that millions of people are dying from TB each year when an inexpensive cure is available? Can we comprehend the magnitude of this injustice?”1 This statement was made by the then WHO Tuberculosis Programme manager Arata Kochi in 1994 in the wake of WHO declaring tuberculosis a global emergency.

[Comment] How feasible is the global elimination of HCV infection?

Fri, 29 Mar 2019 00:00:07 +0000

The introduction of direct-acting antiviral agents in 2013 revolutionised the treatment of hepatitis C virus (HCV) infection.1 With duration of therapy as short as 8 weeks, few side-effects, the fact that more than 90% of patients can be cured, and more affordable drug prices following the introduction of generics, treatment has become a realistic option for many people living with HCV infection. In 2016, approximately 1·5 million people received HCV treatment.2 These treatment-related developments along with an improved understanding of the substantial global morbidity and mortality attributable to viral hepatitis led to increased advocacy for more action to address hepatitis.

[Comment] Elective frozen embryo transfer for all?

Fri, 29 Mar 2019 00:00:07 +0000

Improvements in embryo freezing protocols and the introduction of vitrification to clinical in-vitro fertilisation (IVF) have led to the rapid adoption of so-called freeze-all, freeze-only, deferred embryo transfer, or elective frozen transfer IVF cycles, with the promise of improved pregnancy rates and outcomes.1–4 At present, this approach is indicated for patients with polycystic ovary syndrome (PCOS),5 in those with high ovarian response to gonadotropin stimulation,6,7 and in those undergoing pre-implantation genetic testing;6 but it might not be justified for ovulatory patients using day 3, cleavage-stage embryos for transfer.

[Comment] Bariatric surgery—which procedure is the optimal choice?

Fri, 29 Mar 2019 00:00:07 +0000

Bariatric surgery was originally designed to promote weight loss.1 Nowadays, bariatric surgery is often called metabolic surgery because the procedures, beyond weight loss, improve glycaemia, metabolic syndrome, and non-alcoholic liver disease, and decrease risk of cardiovascular disease more effectively than any pharmacological or lifestyle approach.2,3

[Editorial] Gestational diabetes in England: cause for concern

Fri, 29 Mar 2019 00:00:07 +0000

Gestational diabetes, occurring in about 5% of pregnancies, has well established risk factors, including high body-mass index, a family history of diabetes, and south Asian or afro-Caribbean ethnicity. Just as well known are the serious maternal and neonatal adverse outcomes, including increased risk of miscarriage, macrosomia, complications around delivery, and stillbirth, if gestational diabetes is not diagnosed and controlled.

[Editorial] Coercive sterilisation of transgender people in Japan

Fri, 29 Mar 2019 00:00:07 +0000

The removal of transgender identity as a psychiatric disorder by both WHO and the American Psychiatric Association in the latest editions of the two principal disease classification systems should be an emancipating event for transgender people and health professionals who support them. A conservative estimate is that 0·5% of people identify with a different gender than that assigned to them at birth. But, in the absence of strong evidence to guide gender-affirmation care and in the presence of laws in many countries that reinforce gender stereotypes and discrimination, transgender people are often invisible.

[Editorial] Guinea worm disease eradication: a moving target

Fri, 29 Mar 2019 00:00:07 +0000

Deadlines for the eradication of Guinea worm disease have come and gone without success. The first deadline was set in 1991, when the World Health Assembly adopted a resolution calling for the eradication of the disease, which is caused by the nematode Dracunculus medinensis, within 4 years. This target was not met, so a second 2009 deadline was set; this too was not met. After an additional failed deadline in 2015, a new date of eradication has been scheduled for 2020. However, data from the US Centers for Disease Control and Prevention (CDC) and the Carter Center, a US-based global health non-governmental organisation, puts even this new target in question.

First Kidney Donor With HIV Leads Way for More Transplants

Thu, 28 Mar 2019 18:12:42 +0000

An HIV-positive woman approached her doctor with a seemingly impossible idea -- she wanted to donate a kidney. Monday, she did, and ushered in what could be a new era in renal care for people with HIV.
Medscape Medical News

FDA OKs Certolizumab for Nonradiographic Axial Spondyloarthritis

Thu, 28 Mar 2019 17:00:09 +0000

Certolizumab is the first FDA-approved treatment for this type of inflammatory arthritis and fulfills an unmet need for these patients, the FDA says.
FDA Approvals

Artesunate Now First-Line Treatment for Severe Malaria in US

Thu, 28 Mar 2019 17:31:45 +0000

With quinidine discontinued and no longer available in the US, artesunate is now the first-line treatment for severe malaria in the US, according to the CDC.
Medscape Medical News

New Jersey Jury Finds J&J Not Liable in Latest Talc Cancer Trial

Thu, 28 Mar 2019 16:23:06 +0000

A New Jersey jury on Wednesday cleared Johnson & Johnson of liability in a lawsuit brought by a man who said that asbestos in the company's talcum powder products caused his mesothelioma.
Reuters Health Information

Big Pharma Accused of 'endless Talk, No Action' on Antibiotic Threat

Thu, 28 Mar 2019 16:23:10 +0000

The pharmaceutical industry should match its words with action on researching new antibiotics to address the threat posed by drug-resistant superbugs, a former UK government adviser said on Wednesday.
Reuters Health Information

Trump Says He Can Produce a Better Healthcare Plan Than Obamacare

Thu, 28 Mar 2019 16:23:14 +0000

U.S. President Donald Trump pledged on Wednesday to deliver a better healthcare system than Obamacare if the Supreme Court tosses out his predecessor's signature domestic achievement, a potentially hazardous claim as he seeks re-election.
Reuters Health Information

Diabetes in Pregnancy Tied to Future Heart Disease Risk

Thu, 28 Mar 2019 16:23:23 +0000

Women with pregnancy-related diabetes are at higher risk for developing cardiovascular disease in the decade after childbirth, a research review suggests.
Reuters Health Information

Hemoglobin A1c Misses Many Cases of Diabetes

Thu, 28 Mar 2019 15:34:30 +0000

The hemoglobin A1c blood test used widely to diagnose diabetes is "highly unreliable" with a significant tendency to miss cases of diabetes and overestimate the prevalence of normal glucose tolerance (NGT), according to new research.
Reuters Health Information

Continuing ARB Recalls Shake Up Hypertension, HF Care

Thu, 28 Mar 2019 14:51:34 +0000

Reports of probable carcinogens found in generic sartans are causing concern in hypertension and heart failure practice, and raising larger questions about the safety of the drug supply.
Medscape Medical News

CDC to Start Tracking Ticks as Diseases Rise

Thu, 28 Mar 2019 15:12:55 +0000

For the first time, ticks and the pathogens they can transmit will be tracked across the nation.
WebMD Health News

Big Jump in Enterovirus-D68 Infections in Multisite Survey

Thu, 28 Mar 2019 15:26:50 +0000

The CDC reports a significant rise in enterovirus-D68 (EV-D68) infections in children at seven sites across the US; more surveillance is required to understand trends in EV-D68 infection.
Medscape Medical News

'Toad Venom' Psychedelic May Rapidly Improve Depression, Anxiety

Thu, 28 Mar 2019 14:14:51 +0000

A little-known, fast-acting synthetic psychedelic drug derived from toad venom may improve depression and anxiety, early research suggests.
Medscape Medical News

ADA Updates Standards of Care in Diabetes Based on New Data

Thu, 28 Mar 2019 14:17:50 +0000

Three changes have been made regarding recommendations about CVD management and CKD as part of the new continuously updated 'Living Standards.'
Medscape Medical News

Благодаря редкой мутации женщина не чувствует боль и всегда в хорошем настроении

Thu, 28 Mar 2019 20:30:18 +0000

Жительница Шотландии всю жизнь не чувствовала боли, и только недавно ученые объяснили ей, почему она является феноменом. Оказалось, что она является носителем очень редкой мутации, которая приводит к повышению концентрации естественных обезболивающих веществ в организме.

CMS Coverage Proposal for TAVR Preserves Procedure-Volume Focus

Thu, 28 Mar 2019 13:35:34 +0000

The proposed national coverage determination, TAVR's second since it entered practice and now inviting comments, comes as the field is poised for a shake up following the PARTNER 3 and Evolut trials.
Medscape Medical News

Загрязненность воздуха увеличивает риск психозов у подростков

Thu, 28 Mar 2019 19:54:58 +0000

Молодые люди, живущие в регионах с высоким уровнем загрязнения воздуха, значительно чаще страдают от психотических расстройств. Известно, что люди, выросшие в городах, чаще сталкиваются с психическими расстройствами, чем живущие за городом, а данная научная работа предполагает, что одной из их возможных причин является загрязненный воздух.

'Impressive' Results After Change of HSCT Conditioning Regimen

Thu, 28 Mar 2019 12:15:50 +0000

The conditioning regimen used prior to hematopoietic stem cell transplant in patients with myelofibrosis could have a major impact on relapse rates and overall survival, say Italian researchers.
Medscape Medical News

Death, Severe Impairments Still Common for Tiniest Preemies

Thu, 28 Mar 2019 10:32:31 +0000

Extremely preterm infants weighing less than 400 grams at birth are at risk for significant morbidity and mortality, new data show.
Medscape Medical News

New Studies Support Dropping Long-term Aspirin After Stenting

Thu, 28 Mar 2019 07:36:47 +0000

The STOPDAPT-2 and SMART-CHOICE trials both suggest extended therapy with clopidogrel or another P2Y12 inhibitor alone may be preferable to dual antiplatelet therapy.
Medscape Medical News

Night Shift Work Linked to a Higher Risk of Miscarriage

Thu, 28 Mar 2019 04:18:35 +0000

Pregnant women who work at least two night shifts in one week may have a heightened risk of miscarriage the following week, a new study suggests.
Reuters Health Information

Ночная работа во время беременности может увеличивать риск выкидыша

Thu, 28 Mar 2019 09:46:27 +0000

У беременных женщин, отрабатывающих в течение недели две ночных смены и более, может увеличиваться риск выкидыша на следующей неделе примерно на треть. Наиболее выражена эта связь начиная с восьмой недели.

US Measles Cases Top 300, Emergency Declared in New York County

Wed, 27 Mar 2019 19:56:39 +0000

Measles outbreaks have been reported in six states and a total of 314 confirmed cases have been reported to the CDC in six states in 2019, with most linked to international travel in unvaccinated people.
Medscape Medical News

Delirium Care Reduces Length of Hospital Stay, Cost

Wed, 27 Mar 2019 16:56:38 +0000

When patients determined to be at high risk for delirium were assigned to care for prevention and treatment, length of hospital stay dropped by almost a full day per patient.
Medscape Medical News

Doctors With Multiple Malpractice Claims Enter Solo Practice

Wed, 27 Mar 2019 17:13:40 +0000

The greater likelihood of doctors with five or more paid malpractice claims switching to solo practice presents a potential patient safety concern.
Medscape Medical News

FDA OKs Oral Testosterone for Certain Forms of Hypogonadism

Wed, 27 Mar 2019 17:19:48 +0000

Jatenzo should not be used to treat older men with age-related hypogonadism because the benefits do not outweigh the risks, which include elevated blood pressure, the FDA said.
FDA Approvals

FDA OKs Brain Stimulator for Insomnia, Anxiety, Depression

Wed, 27 Mar 2019 15:54:20 +0000

Cervella is the first cranial electrotherapy stimulator with electrodes seamlessly integrated into noise-cancelling Bluetooth headphones.
FDA Approvals

Hs Troponin Assay Leads to Overdiagnosis of MI?

Wed, 27 Mar 2019 15:55:59 +0000

The high-sensitivity troponin assay has become the gold standard for diagnosing MI, but a new study suggests current thresholds may lead to overdiagnosis of MI and inappropriate treatment.
Medscape Medical News

Program Curbs Alcohol Detox Admissions

Wed, 27 Mar 2019 16:25:13 +0000

Patients with alcohol withdrawal syndrome can be treated safely on an outpatient basis, new research shows, decreasing hospital admissions and shortening hospital stays.
Medscape Medical News

Unique Video Game May Improve Function in Stroke Survivors

Wed, 27 Mar 2019 14:27:37 +0000

Forget reaching for a high score -- stroke survivors who completed movement tasks using a video game interface showed improved arm function.
Medscape Medical News

Многие диагнозы женщинам ставят на несколько лет позже, чем мужчинам

Tue, 26 Mar 2019 11:02:05 +0000

В среднем женщинам ставят диагноз рака на 2,5 года позже, чем мужчинам, а сахарного диабета – на 4,5 года позже. Ученые не знают наверняка, что является причиной поздней диагностики. Среди возможных причин генетические особенности, факторы окружающей среды, возможные отклонения со стороны системы здравоохранения.

Рак у детей: огромная пропасть в пятилетней выживаемости

Wed, 27 Mar 2019 19:33:59 +0000

Ежегодно у 429000 детей и подростков развивается рак. По данным педиатрического исследования рака, опубликованного в специальном выпуске журнала Science, подавляющее большинство из них (384000) живет в развивающихся странах. Ученые выявили поразительное неравенство между выживаемостью от рака у детей из развитых и из развивающихся стран – более 80% и менее 30% соответственно.

PIONEER-3: Oral Semaglutide Shows Benefit in Type 2 Diabetes

Wed, 27 Mar 2019 12:53:09 +0000

Higher doses of oral semaglutide reduce HbA1c better than sitagliptin in type 2 diabetes but has more gastrointestinal side effects. NDAs for the product have just been filed in the US.
Medscape Medical News

Даже небольшое количество красного мяса ускоряет приход смерти

Wed, 27 Mar 2019 19:28:18 +0000

Употребление в пищу красного и переработанного мяса даже в небольших количествах может повысить риск смерти от любых причин, в первую очередь от сердечно-сосудистых заболеваний.

Рак у детей: огромная пропасть в пятилетней выживаемости

Wed, 27 Mar 2019 19:33:59 +0000

Should Physicians Share Their Own Diagnosis With Patients?

Wed, 27 Mar 2019 10:57:31 +0000

A physician says telling patients about your own illness may have an upside.
Medscape Reader Polls

Apple Heart Study Raises Myriad Questions

Wed, 27 Mar 2019 11:18:27 +0000

The Apple Heart Study produced an 84% positive predictive value for atrial fibrillation, but it raises important questions about wearable consumer health devices and how medicine will deal with them.
Medscape Medical News

Study Linking Autism to 'Male Brain' Retracted, Replaced

Wed, 27 Mar 2019 11:37:09 +0000

The authors of a study that claimed to find a link between typical male brain anatomy and autism spectrum disorder have retracted it and replaced it with a dramatically changed version.
Medscape Medical News

MS May Not Worsen After Childbirth After All

Wed, 27 Mar 2019 11:42:41 +0000

Women with MS today can have children, breastfeed, and resume MS therapy without increasing their risk of relapse after delivery, new research suggests.
Medscape Medical News

CardioMEMS PA-Pressure-Guided HF Therapy Safe, Reduces Events

Wed, 27 Mar 2019 10:38:46 +0000

Hospitalizations were fewer in a large postapproval study of heart failure management guided by the implanted pulmonary artery pressure sensor, largely consistent with the CHAMPION trial.
Medscape Medical News

Две трети тяжелых больных не знают, что имеют право на инвалидность

Wed, 27 Mar 2019 09:03:51 +0000

Отсутствие денег на лекарства и сложности с получением инвалидности, дающей право на бесплатные препараты и средства реабилитации – широко распространенные проблемы пациентов с тяжелыми хроническими заболеваниями в России. Многие больные люди даже не знают, что имеют право на получение инвалидности, а медики не торопятся направлять их на медико-социальную экспертизу.

Trump Doubles Down on Obamacare Fight, Asks Court to Overturn Law

Wed, 27 Mar 2019 00:27:48 +0000

U.S. President Donald Trump's administration has stepped up its attack on the Obamacare health care law, telling a federal appeals court it agrees with a Texas judge's ruling that the law is unconstitutional and should be struck down.
Reuters Health Information

Democrats Pounce as Trump Administration Ratchets Up Attack on Obamacare

Wed, 27 Mar 2019 00:27:54 +0000

Top congressional Democrats on Tuesday attacked a legal move by the Trump administration to step up its assault on the Obamacare healthcare law, saying last November's elections showed Americans want them to protect the Affordable Care Act. The Justice Department, in a two-sentence letter to the U.S. 5th Circuit Court of Appeals filed on Monday, said it backed a federal judge's ruling in Decem...
Reuters Health Information

Springtime Heralds Moose Collision Season in New England

Tue, 26 Mar 2019 23:22:25 +0000

Drivers in northern New England have long known to watch out for moose on the road, but a new study finds potentially fatal collisions with these large animals still happen on average more than once a day.
Reuters Health Information

Obamacare Enrollments Drop Marginally for 2019

Tue, 26 Mar 2019 23:22:54 +0000

Enrollments in healthcare plans for 2019 through the Federal Obamacare marketplace dropped marginally by 300,000 from last year, according to U.S. government figures released on Monday.
Reuters Health Information

Oklahoma Top Court Clears Way for Purdue, J&J, Teva to Face Opioid Trial

Tue, 26 Mar 2019 23:23:21 +0000

Oklahoma's top court on Monday declined to delay a landmark trial set for May in a multibillion-dollar lawsuit accusing OxyContin maker Purdue Pharma LP and two other drugmakers of helping fuel an opioid abuse and overdose epidemic in the state.
Reuters Health Information

Bayer, J&J Settle Thousands of U.S. Xarelto Lawsuits for $775 Mln

Tue, 26 Mar 2019 23:23:50 +0000

Bayer AG and Johnson & Johnson have agreed to settle more than 25,000 U.S. lawsuits alleging that their blockbuster blood thinner Xarelto (rivaroxaban) aused unstoppable and in some cases fatal bleeding for a total of $775 million, court documents on Monday showed.
Reuters Health Information

FDA Approves Siponimod (Mayzent) for Multiple Sclerosis

Tue, 26 Mar 2019 20:17:04 +0000

The agency has approved a new oral agent for relapsing forms of multiple sclerosis, including clinically isolated syndrome and secondary progressive disease.
FDA Approvals

Drug Rationing Common for Shortages, Patient Disclosure Rare

Tue, 26 Mar 2019 19:35:12 +0000

A new survey shows that in this era of continuing drug shortages rationing is common in hospitals and patients aren't always aware.
Medscape Medical News

Giving Up Alcoholic Drinks in AF May Cut AF Burden, Recurrence

Tue, 26 Mar 2019 16:43:10 +0000

Moderate drinkers in sinus rhythm after atrial fibrillation had fewer recurrences after stopping or at least cutting sharply back on their alcohol intake in a groundbreaking randomized trial.
Medscape Medical News

Diabetes and Kidney Complications Garnering Attention at ISN

Tue, 26 Mar 2019 13:38:55 +0000

First results indicating that an SGLT2 inhibitor could improve outcomes for patients with diabetes and chronic kidney disease will be presented at the upcoming nephrology world congress.
Medscape Medical News

Steady Drop in Medication Mix-ups With New Approach

Tue, 26 Mar 2019 12:21:30 +0000

Simple steps can significantly reduce prescribing errors, which are a constant source of frustration for hospitals, an extension of the MARQUIS study shows.
Medscape Medical News

HSCT Remains Standard in Childhood ALL, Despite CAR T-Cells

Tue, 26 Mar 2019 12:40:55 +0000

Clinicians should continue to rely on matched donor stem cell transplants to treat childhood acute lymphoblastic leukemia, while more data on novel CAR T-cell therapies is gathered, says German expert.
Medscape Medical News

Stem Cell Transplant Patients Face Lifelong Cancer Risk

Tue, 26 Mar 2019 12:52:40 +0000

Patients undergoing hematopoietic stem cell transplant should be counseled that they have an ever-increasing risk for further malignancies, although their survival may not be affected, say experts.
Medscape Medical News

Цветные фрукты и овощи в рационе могут предотвратить возрастную катаракту

Tue, 26 Mar 2019 17:05:01 +0000

Многообразие цветных фруктов и овощей в рационе способно предотвратить развитие возрастных катаракт. Они содержат витамины и каротиноиды, которые связаны со сниженным риском развития возрастных катаракт, включая витамины А, С, Е, β-каротин, лютеин и зеаксантин.

No Link Between Smoking and Increased Dementia Risk?

Tue, 26 Mar 2019 10:48:26 +0000

Smoking causes serious diseases and increases mortality. This study suggests, however, that it may not increase the risk of dementia because many smokers will die before dementia sets in.
Medscape Medical News

Testosterone Prevents Progression to Diabetes in Hypogonadal Men

Tue, 26 Mar 2019 10:48:45 +0000

Hypogonadal men with prediabetes could halt their progression to type 2 diabetes and return to normoglycemia with testosterone therapy, in results described as 'dramatic' and likely to have 'impact.'
Medscape Medical News

Meet the Whistleblower Who Just Cost Duke $112.5 Million

Tue, 26 Mar 2019 11:16:45 +0000

Joseph Thomas turned frustration about faulty research into more than $30 million -- and is hopeful for the future of scientific integrity.
Medscape Medical News

Heartmate 3 LVAD Impresses in Final MOMENTUM 3 Data

Tue, 26 Mar 2019 09:04:07 +0000

Patients with advanced heart failure now have an option other than heart transplantation: a more forgiving heart pump that has now been studied out to 2 years in a large population.
Medscape Medical News

Chronic Medication Use, Polypharmacy Common Among Children

Tue, 26 Mar 2019 09:15:12 +0000

One in five children with Medicaid insurance used at least one chronic medication each year and almost 1 in 10 took multiple chronic medications, a large retrospective study found.
Medscape Medical News

Camera on Google Glass May Boost Social Skills in Kids With ASD

Tue, 26 Mar 2019 07:36:17 +0000

Wearable digital technology may help children recognize facial expressions and identify emotions, study authors say.
Medscape Medical News

Специалисты предлагают включить УЗИ молочных желез в программу диспансеризации школьниц

Tue, 26 Mar 2019 12:35:06 +0000

По официальной статистике, около 30% случаев рака молочной железы в нашей стране впервые диагностируют у женщин в возрасте от 18 до 35 лет. При этом от бессимптомного течения болезни до явных клинических проявлений может пройти 6-10 лет, то есть начаться болезнь может в подростковом возрасте.

Многие диагнозы женщинам ставят на несколько лет позже, чем мужчинам

Tue, 26 Mar 2019 11:02:05 +0000

В среднем женщинам ставят диагноз рака на 2,5 года позже, чем мужчинам, а сахарного диабета – на 4,5 года позже. Ученые не знают наверняка, что является причиной поздней диагностики: генетические особенности, факторы окружающей среды, возможные отклонения со стороны системы здравоохранения.

Catheter for AF Maps, Ablates, and Sees Inside the Heart

Mon, 25 Mar 2019 17:00:34 +0000

A balloon catheter in development to treat atrial fibrillation incorporates ablation, mapping, and visualization inside the heart. An early study shows excellent rates of ablation and procedure time.
Medscape Medical News

Cannabis-Linked ED Visits: Smoking vs Eating Matters

Mon, 25 Mar 2019 17:15:18 +0000

Cannabis-related visits to the emergency department spiked in Colorado after marijuana was legalized there, with visits as a result of inhalable use being more frequent than from edible use.
Medscape Medical News

New Guidelines Address Osteoporosis Treatment Postmenopause

Mon, 25 Mar 2019 17:31:06 +0000

The Endocrine Society's new guidelines advise bisphosphonates and denosumab as first line for lower-risk women and anabolic treatments as first line for those at very high fracture risk.
Medscape Medical News

За 13 лет радикально усилилось влияние телефона на здоровье

Mon, 25 Mar 2019 23:08:30 +0000

Каждая пятая женщина и каждый восьмой мужчина меньше спят, так как больше времени проводят с мобильными телефонами. За последние 13 лет случился резкий скачок «техноференции», когда современные технологии препятствуют нормальной жизни.

MI Less Frequent, Less Deadly Over 20 Years

Mon, 25 Mar 2019 16:00:09 +0000

Over the past 20 years, fewer older adults suffered myocardial infarction and outcomes improved in the United States, likely thanks to national prevention efforts and improved care, researchers say.
Medscape Medical News

Big Alcohol Knocks Back Medical Clout on Drinking

Mon, 25 Mar 2019 16:25:28 +0000

Policies that curb alcohol consumption will help people most in need of intervention, one expert explains, as the drinks-industry lobby dukes it out with medical specialists and regulatory officials.
Medscape Medical News

Mental Health Apps: Boon or Bust?

Mon, 25 Mar 2019 14:19:23 +0000

The use of mental health apps has burgeoned in recent years. New research examines whether they are effective, user-friendly, and safe.
Medscape Medical News

10 Years to a Male Contraceptive?

Mon, 25 Mar 2019 14:49:16 +0000

Reporting preliminary results of another potential 'male pill', researchers are optimistic that a contraceptive for men will be commercially available within a decade.
Medscape Medical News

Ticagrelor Reversal Agent on the Horizon

Mon, 25 Mar 2019 14:49:26 +0000

A reversal agent for the P2Y12 inhibitor may soon be available after results of a new study showed immediate and sustained reversal of the antiplatelet effects of the drug.
Medscape Medical News

In New Offensive Against HIV, Metro Atlanta Is a Battleground

Mon, 25 Mar 2019 11:49:41 +0000

President Trump's HIV strategy, announced during his State of the Union address last week, will target hot spots for HIV infection, such as Metro Atlanta.
Georgia Health News

Who Is the Longest-Lived President?

Mon, 25 Mar 2019 12:54:08 +0000

Former President Jimmy Carter has lived longer than any other president in US history.
Georgia Health News

Курение будущего отца увеличивает риск порока сердца у ребенка

Mon, 25 Mar 2019 19:40:32 +0000

Курение будущих отцов увеличивает риск врожденных пороков сердца у детей, согласно исследованию, опубликованному в European Journal of Preventive Cardiology. Что касается будущих матерей, негативное воздействие на потомство оказывает как их собственное, так и пассивное курение.

In New Offensive Against HIV, Metro Atlanta Is a Battleground

Mon, 25 Mar 2019 11:49:41 +0000

President Trump's HIV strategy, announced during his State of the Union address last week, will target hot spots for HIV infection, such as Metro Atlanta.
Medscape Medical News

Duke Settles Doctored Data Lawsuit for $112.5 Million

Mon, 25 Mar 2019 11:58:52 +0000

A whistleblower said that lung researchers had faked data in grant applications totaling $200 million.
Medscape Medical News

FDA Panel Nixes Novel Alzheimer's Therapy

Mon, 25 Mar 2019 12:45:43 +0000

An FDA advisory panel questions the evidence showing beneficial effects of a therapy that combines transcranial magnetic stimulation with cognitive training.
Medscape Medical News

In Africa, US Cancer Guidelines Are 'Harmonized' to Locale

Mon, 25 Mar 2019 10:56:17 +0000

The well-regarded National Comprehensive Cancer Network guidelines are being adapted for regional use in Africa, but the high cost of cancer drugs is a problem.
Medscape Medical News

Childhood Maltreatment Ups Risk for Recurrent Depression

Mon, 25 Mar 2019 11:09:15 +0000

A brain imaging study identified ties between childhood maltreatment, brain structural alterations, and vulnerability to recurrent depression.
Medscape Medical News

In New Offensive Against HIV, Metro Atlanta Is a Battleground

Mon, 25 Mar 2019 11:49:41 +0000

President Trump's HIV strategy, announced during his State of the Union address last week, will target hot spots for HIV infection, such as Metro Atlanta.

Osilodrostat Continues to Show Promise for Cushing's Disease

Mon, 25 Mar 2019 10:24:21 +0000

The investigational 11β-hydroxylase normalized mean urinary free cortisol in most patients and was well-tolerated.
Medscape Medical News

Медицинские мобильные приложения не берегут наши личные данные

Mon, 25 Mar 2019 12:12:17 +0000

Многие популярные приложения, связанные со здоровьем, не обеспечивают конфиденциальности. Они делятся закрытыми данными с коллегами и другими корпорациями, последствие этого сложно предсказать. Ученые выяснили непрозрачные схемы утечки персональной информации.

ADA and ACP Docs Debate Diabetes Goals: Outcome Is Surprise

Sun, 24 Mar 2019 16:40:24 +0000

'A reasonable HbA1c goal for many nonpregnant adults with diabetes is < 7%.' Debate follows controversy last year when the American College of Physicians issued looser HbA1c guidelines than ADA.
Medscape Medical News

T4 Doesn't Prevent Miscarriages in Antibody-Positive Women

Sat, 23 Mar 2019 19:17:45 +0000

Giving thyroid hormone replacement before conception didn't prevent miscarriages or other adverse pregnancy outcomes in euthyroid women with thyroid peroxidase antibodies, shows the TABLET trial.
Medscape Medical News

New Endocrine Society Guidelines Address Diabetes in Older Adults

Sat, 23 Mar 2019 15:53:28 +0000

Document covers screening, prevention, management of glycemia, blood pressure, and lipids, as well as comorbidities, complications, and special situations.
Medscape Medical News

Over One Third of Type 1 Diabetes Patients Quit Closed-Loop System

Sat, 23 Mar 2019 13:12:19 +0000

Real-world data show MiniMed 670G (the 'artificial pancreas') is difficult to use for those with type 1 diabetes, with technical problems forcing many to quit within a few months.
Medscape Medical News

Better Methods Needed to Diagnose Thyroid Neoplasm, NIFTP

Sat, 23 Mar 2019 13:48:07 +0000

Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) cannot be accurately diagnosed presurgically with ﬁne-needle aspiration cytology, according to a new meta-analysis.
Medscape Medical News

Screening Ultrasonography Does Not Improve Breast-cancer Detection

Fri, 22 Mar 2019 22:35:17 +0000

Rates of breast-cancer detection are similar after screening mammography with or without screening ultrasonography, according to an observational study.
Reuters Health Information

Laser Treatment of Port-wine Stains Feasible Without General Anesthesia in Infants

Fri, 22 Mar 2019 22:36:42 +0000

Port-wine-stain birthmarks can be safely and effectively treated in early infancy with pulsed dye laser without the need for general anesthesia, according to new research.
Reuters Health Information

Water Is Now Gold for Desperate Venezuelans

Fri, 22 Mar 2019 22:37:04 +0000

Living with a scarcity of water is becoming the norm for many Venezuelans.
Reuters Health Information

Roche Sues U.S. Executives in Diabetes Test Strip Fight

Sat, 23 Mar 2019 00:07:07 +0000

Roche is seeking tens of millions of dollars in a U.S. lawsuit against former executives of a Utah-based pharmacy company in the Swiss drugmaker's latest court case targeting what it calls fraudulent diabetes test strip schemes.
Reuters Health Information

Burnout Rates on the Rise at Academic-faculty Practice Organization

Sat, 23 Mar 2019 00:07:51 +0000

Burnout rates among physicians at a multispecialty academic-faculty practice organization increased significantly between 2014 and 2017, according to a survey.
Reuters Health Information

Outpatient Parenteral Antimicrobial Therapy Safe, Effective for Pediatric Cellulitis

Sat, 23 Mar 2019 00:08:30 +0000

Outpatient parenteral antimicrobial therapy (OPAT) is noninferior to in-hospital intravenous therapy for children with cellulitis, according to results from the CHOICE trial.
Reuters Health Information

Many Catholic Hospitals Fail to Disclose Religious Affiliation, Restrictions Online

Sat, 23 Mar 2019 00:08:52 +0000

Patients should know if the hospital they choose will restrict their care for religious reasons, but among nearly 650 Catholic hospitals in the U.S., a new study finds that one in five don't explicitly disclose this information on their websites.
Reuters Health Information

New Technique May Help Detect Hydroxychloroquine-induced Eye Problems

Sat, 23 Mar 2019 00:44:33 +0000

Swept-source optical coherence tomography angiography (SS-OCTA) may detect eye abnormalities in patients taking hydroxychloroquine (HCQ) longer than five years to treat systemic lupus erythematosus (SLE), a pilot study conducted in Spain suggests.
Reuters Health Information

Metabolic Syndrome May Predict Lung Damage in 9-11 Responders

Sat, 23 Mar 2019 00:45:09 +0000

For firefighters who worked at "Ground Zero" around September 11, 2001, a group of heart-disease risk factors also predicted who was likely to develop World Trade Center-related lung injury years later, researchers say.
Reuters Health Information

Phone App May Help Conquer Fear of Heights

Sat, 23 Mar 2019 00:45:27 +0000

People who are terrified of heights may be able to conquer their phobia using a virtual reality app and an inexpensive set of cardboard VR googles, a Dutch study suggests.
Reuters Health Information

IVIG Plus Cyclosporine Boosts Heart Outcomes in Resistant Kawasaki Disease

Sat, 23 Mar 2019 00:45:46 +0000

Adding cyclosporine to intravenous immunoglobulin (IVIG) may prevent adverse coronary artery outcomes in Kawasaki disease patients at risk of not responding to IVIG alone, researchers say.
Reuters Health Information

Neonatal Surgeries for Complex Congenital Heart Disease Rise, Remain High After Fukushima

Sat, 23 Mar 2019 00:46:08 +0000

Following the 2011 Fukushima nuclear accident in Japan, complex congenital heart disease (CHD) operations increased in neonates, and the number of operations remain high despite declining air levels of radiation, researchers say.
Reuters Health Information

FDA Turns Down Sotagliflozin for Type 1 Diabetes

Fri, 22 Mar 2019 18:15:53 +0000

Advisory panel had expressed major concerns about diabetic ketoacidosis.
Medscape Medical News

ER Doc Survives Cancer, Now Must Survive ER

Fri, 22 Mar 2019 15:53:10 +0000

A Florida-based ER physician with an aggressive lymphoma underwent a 'miracle' treatment but now has a weakened immune system. Back at work, now he has to survive the ER and its germs.
Medscape Medical News

FDA Warns of Cyber Risk in Medtronic ICD, CRT-D Telemetry Systems

Fri, 22 Mar 2019 14:15:54 +0000

Hackers could potentially exploit security vulnerabilities in certain Medtronic CareLink systems to reprogram implanted devices, if they are nearby with the right equipment, says the agency.
News Alerts

ДТП, насилие, врожденные патологии. Непьющие тоже страдают от алкоголя

Thu, 21 Mar 2019 09:52:58 +0000

Немецкое исследование, результаты которого опубликованы в журнале BMC Medicine, оценило вред от употребления алкоголя, но не для самих пьющих, а для третьих лиц.

Instagram обещает заблокировать антипрививочные хэштеги

Fri, 22 Mar 2019 18:57:43 +0000

На фоне продолжающейся в соцсетях кампании дезинформации по поводу применения вакцин Instagram планирует заблокировать антипрививочные хэштеги. Три недели назад Facebook, владеющий компанией, обнародовал планы борьбы с контентом, направленным против вакцинации. Но на днях в крупных СМИ появились сообщения, что обещанные меры все еще не приняты.

Бактерии в моче не всегда говорят о необходимости лечения

Fri, 22 Mar 2019 19:19:48 +0000

Ученые призывают не проводить скрининг на наличие бактерий в моче людям, у которых нет симптомов инфекции мочевыводящих путей (ИМП). Часто выявляемая в таких случаях бессимптомная бактериурия становится причиной злоупотребления антибиотиками.

Pace of Multiple Sclerosis Progression May Be Slowing

Fri, 22 Mar 2019 11:19:29 +0000

The risk for reaching specific disability milestones in patients with multiple sclerosis has decreased over the past decade, a large cohort study from Sweden suggests.
Medscape Medical News

Reducing C-Section Rates Doesn't Harm Mother or Baby

Fri, 22 Mar 2019 10:01:53 +0000

Even among California hospitals that had the biggest reduction in cesarean delivery rates, or drops to rates below 20%, neither maternal nor neonatal rates of complications rose.
Medscape Medical News

COAPT Substudy Spotlights QOL Gains With MitraClip

Fri, 22 Mar 2019 10:13:58 +0000

Even after the high rate of death in both groups is accounted for, the new results show little waning of health status benefits with the MitraClip over time.
Medscape Medical News

Stop Limiting Access to Opioid Addiction Meds, Experts Say

Fri, 22 Mar 2019 10:27:57 +0000

A new report from the National Academies of Science seeks expanded use of methadone, buprenorphine, and naltrexone to help patients combat opioid use disorder.
Medscape Medical News

Atezolizumab Safe in Advanced Urothelial Cancer

Fri, 22 Mar 2019 08:57:36 +0000

The SAUL phase 3b trial met its primary safety endpoint, but the comparative efficacy of the anti-PD-L1 agent in a broader population is still up in the air.
Medscape Medical News

New Study to Explore Issues, Vision for Next Decade of Nursing

Fri, 22 Mar 2019 07:02:00 +0000

A National Academies ad hoc committee met to discuss the beginning of a new study on how nursing can improve health and well-being in the United States during the next decade.
Medscape Medical News

Стартовал четырехмесячный эксперимент международного проекта SIRIUS

Fri, 22 Mar 2019 10:59:21 +0000

Основная задача изоляционного исследования по имитации длительного космического полета на Луну – оценить факторы стресса в мультикультурной команде в условиях ограниченного пространства. На этом этапе в исследовании принимают участие шесть членов экипажа из России и США: трое мужчин и три женщины.

[Review] Venezuela's public health crisis: a regional emergency

Fri, 22 Mar 2019 00:00:08 +0000

The economic crisis in Venezuela has eroded the country's health-care infrastructure and threatened the public health of its people. Shortages in medications, health supplies, interruptions of basic utilities at health-care facilities, and the emigration of health-care workers have led to a progressive decline in the operational capacity of health care. The effect of the crisis on public health has been difficult to quantify since the Venezuelan Ministry of Health stopped publishing crucial public health statistics in 2016.

[Clinical Picture] Heroin body-packing and naloxone

Fri, 22 Mar 2019 00:00:08 +0000

A 28-year-old man was transferred to our hospital after he suddenly lost consciousness in the street. He had an initial diagnosis of opioid overdose. Further, because of respiratory depression, hypoxaemia, miosis, loss of consciousness, and an absence of focal neurological signs and symptoms, the patient was given progressively larger doses of naloxone until he regained consciousness and started breathing normally and spontaneously. He said he had been abusing heroin and so because of this, and the clinical presentation, he was transferred to a clinical toxicology ward for further management.

[Articles] Anal incontinence after caesarean and vaginal delivery in Sweden: a national population-based study

Fri, 22 Mar 2019 00:00:08 +0000

The risk of developing anal incontinence increases after pregnancy and delivery. Women with known risk factors for anal incontinence should perhaps be offered a more qualified post-partum examination to enable early intervention in case of injury. Further knowledge for optimal management are needed.

[Articles] Medically assisted reproduction and birth outcomes: a within-family analysis using Finnish population registers

Fri, 22 Mar 2019 00:00:08 +0000

Children conceived by medically assisted reproduction face an elevated risk of adverse birth outcomes. However, our results indicate that this increased risk is largely attributable to factors other than the medically assisted reproduction treatment itself.

[Articles] Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial

Fri, 22 Mar 2019 00:00:08 +0000

VOT was a more effective approach to observation of tuberculosis treatment than DOT. VOT is likely to be preferable to DOT for many patients across a broad range of settings, providing a more acceptable, effective, and cheaper option for supervision of daily and multiple daily doses than DOT.

[Articles] Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial

Fri, 22 Mar 2019 00:00:08 +0000

Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients.

[Department of Error] Department of Error

Fri, 22 Mar 2019 00:00:08 +0000

Huang SS, Septimus E, Kleinman K, et al. Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial. Lancet 2019; 393: 1205–15—In table 2, the number of routine-care patients in the row “Hospitals with highest quartile baseline rate of all-pathogen bloodstream infections” should have been 40 621, the p value for row “All-pathogen bloodstream infections” should have been 0·71, and there should have been no p value for row “Patients with medical devices”.

[Department of Error] Department of Error

Fri, 22 Mar 2019 00:00:08 +0000

Azzopardi PS, Hearps SJC, Francis KL, et al. Progress in adolescent health and wellbeing: tracking 12 headline indicators for 195 countries and territories, 1990–2016. Lancet 2019; 393: 1101–18—In figure 3 of this Article, under the Social determinants heading, the text should have read “Adolescent livebirths* per 1000 population”. This correction has been made to the online version as of March 21, 2019.

[Correspondence] Palestinian health care is a global responsibility

Fri, 22 Mar 2019 00:00:08 +0000

We welcome Richard Horton's Offline (Nov 3, 2018, p 1612),1 in which he deemed the health of Palestinians a global responsibility. Our work with Palestinian colleagues at the Foundation for Family Medicine in Palestine is an example of how clinical academics from the UK support the development of health care in the West Bank and Gaza. We have colleagues in Israel who want to contribute to this work but are prevented from doing so by an Israeli military ban on citizens travelling to the Palestinian Authority A Zones where Palestinian medical schools are based.

[Correspondence] Methods to overcome vaccine hesitancy

Fri, 22 Mar 2019 00:00:08 +0000

The Editors (Nov 17, 2018, p 2139)1 identified vaccine hesitancy as an important barrier to achieving the 2020 targets for immunisation. Hesitation and resistance to vaccination is a substantial issue in some districts of Kerala, India. In the Malappuram district of Kerala, which has a substantial Muslim population, we found that factors such as religion have only a minor role in resistance to vaccination (unpublished findings). Many religious leaders openly support vaccination drives and consider that religious texts and beliefs do not oppose disease prevention.

[Correspondence] UN concerned about the right to health for migrants in Germany

Fri, 22 Mar 2019 00:00:08 +0000

In October, 2018, the UN Committee on Economic, Social and Cultural Rights published its concluding observations on Germany,1 raising serious concerns about the implementation of the right to health for non-nationals. In July, 2018, in response to a list of issues raised by the UN body, the German Government stated that “[p]rompt access to high-quality health care and treatment is guaranteed in Germany”, and that the applicable rules also permit appropriate health-care provision for non-nationals.

[Correspondence] Action on salt in China – Authors' reply

Fri, 22 Mar 2019 00:00:08 +0000

We are very grateful to Luke Allen for his Correspondence on our Comment.1 We fully agree that a legislative approach is more effective than a voluntary one in any diet and lifestyle interventions to prevent cardiovascular disease. However, introducing legislation might not be possible for most countries, and the long and complicated process of implementing legislation could severely delay action. For example, the pace of regulating the tobacco industry clearly illustrates how it could take several decades to get legislation through.

[Correspondence] Action on salt in China

Fri, 22 Mar 2019 00:00:08 +0000

He and colleagues (July 7, 2018, p 7)1 argue that it is best to start with voluntary salt reduction targets for industry while regulation and legislation are enacted on the basis that complex legislative processes can delay action. It is important to clarify that the legislative process should start before any invitation to voluntary reformulation is extended. Although voluntary industry targets have undoubtedly worked well in the UK,2 ensuring that industry-led initiatives do not postpone effective legislation is crucial.

[Correspondence] Beyond representation: women at global health conferences

Fri, 22 Mar 2019 00:00:08 +0000

Demands to improve the representation of women in global health are not new, and diverse social movements have been striving to advance the agenda.1,2 Recently, The Lancet has contributed to efforts to raise the visibility and recognition of women in global health.3 These efforts share the common pursuit of equal rights, responsibilities, and opportunities for all genders, and are advocating that the interests, needs, and priorities of all are considered.

[Correspondence] End government support for pro-alcohol research

Fri, 22 Mar 2019 00:00:08 +0000

In the 1960s, the Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia's leading scientific body, developed and imported mechanical grape harvesters using public funding. Because of government support, Australia skyrocketed from being responsible for less than 1% of global production to becoming the fifth largest global wine producer.

[Correspondence] Post-Brexit food standards

Fri, 22 Mar 2019 00:00:08 +0000

With UK trade relations unclear over Brexit, food standards are fast becoming a key test for public health in trade matters. On Feb 28, 2019, the US Trade Representative (USTR) published the US negotiating position on a post-Brexit US–UK trade deal.1 USTR made clear that the UK must abandon the EU's high food safety, animal welfare, and environmental protection standards as a condition for agreeing the kind of deal many Brexiteers desire. On March 2, the US Ambassador to the UK attacked EU standards, calling Europe's food and farming a museum.

[Obituary] Martin Eric Gore

Fri, 22 Mar 2019 00:00:08 +0000

Medical oncologist and pioneer of immunotherapy. He was born in London, UK, on Feb 18, 1951, and died there after an allergic reaction to a vaccination on Jan 9, 2019, aged 67 years.

[Perspectives] Abortion as a moral good

Fri, 22 Mar 2019 00:00:07 +0000

My medical students first hear from a family physician who describes himself as pro-life. He's Christian, and his faith is “a large part of the reason” he refuses to perform abortions. “Christ says things like do to others what you want them to do to you, or love your neighbour as yourself, and when I'm in the room with a pregnant patient I think I have two neighbours in there”, he tells the second years. Then they hear from an obstetrician who specialises in abortion care. She too is a Christian, and some students look surprised when she says her religious beliefs are one reason she sought fellowship training in abortion.

[Perspectives] Anthony Fauci: fighting HIV/AIDS from the beginning

Fri, 22 Mar 2019 00:00:07 +0000

Anthony Fauci has refused the role of Director of the US National Institutes of Health (NIH) four times under different presidents: “Each time, I convinced the President that I would be most effective staying in my current role as Director of NIH's National Institute of Allergy and Infectious Diseases (NIAID)”, Fauci told The Lancet. Under Fauci's leadership at NIAID many of the key HIV milestones have been achieved, including the development and testing of most licensed antiretrovirals (ARVs) and research for a vaccine.

[Perspectives] Waiting for deep medicine

Fri, 22 Mar 2019 00:00:07 +0000

Waiting—it's an odd thing. In theory it is a verb, but the reality is it almost resembles an emotion, a feeling of being neither here nor there. As an emergency medicine doctor, I see a lot of waiting. The wait to be seen, waiting for results, waiting for a specialist, and, if needed, waiting for a bed. With all this waiting it's no wonder my patients and I are often frustrated. Waiting can sometimes feel like a state of limbo, helplessness, or lack of being cared for. But there are also pressures—pressures on the time we can spend with patients, increasing administrative burdens, imperfect electronic health systems, insufficient sleep, to name but a few.

[World Report] Mali announces far-reaching health reform

Fri, 22 Mar 2019 00:00:07 +0000

Mali, a country in west Africa with one of the world's worst health indices, aims to become a model for health reforms on the continent. Paul Adepoju reports.

[World Report] Second person reported in remission from HIV infection

Fri, 22 Mar 2019 00:00:07 +0000

Twelve years on from the so-called Berlin patient, a second patient in London, UK, appears to be in remission from HIV infection. Tony Kirby reports.

[World Report] Madagascar's battle for health

Fri, 22 Mar 2019 00:00:07 +0000

A rampant measles outbreak in Madagascar reveals a health-care system under pressure in a country that is weakened by corruption. Munyaradzi Makoni reports.

[Comment] Offline: Public health and the fight against extremism

Fri, 22 Mar 2019 00:00:07 +0000

“Terrible beyond contemplation”, wrote a friend from New Zealand last week after the assaults on two mosques in Christchurch. Most politicians unreservedly condemned the March 15 attacks, examples of white nationalist terrorism that left 50 people dead and many injured. There have been notable exceptions to this worldwide revulsion, with some voices legitimising the hate speech of alleged perpetrator Brenton Harrison Tarrant, the 28-year-old Australian now charged with murder. Australian Queensland Senator Fraser Anning wrote about “the growing fear within our community, both in Australia and New Zealand, of the increasing Muslim presence”.

[Comment] The political economy of NCDs, and the limits of global health

Fri, 22 Mar 2019 00:00:07 +0000

In 2009, Koplan and colleagues described global health as “the area of study, research and practice that places a priority on improving health and achieving equity in health for all people”.1 10 years later, does this definition still make sense? If so, why is global health not improving “health for all people”?2 Where does global health fit in the bigger picture of a world where inequalities are growing?3 A more honest and constructive conversation is needed about global health and its potential to help reduce inequities.

[Comment] Closing the loop in India's sanitation campaign for public health gains

Fri, 22 Mar 2019 00:00:07 +0000

The prevalence of stunting in India (38·4%)1 is among the highest in the world,2 and diarrhoea is a major killer of children younger than 5 years.3 Both these conditions closely relate to unsafe water, sanitation, and hygiene. The Swachh Bharat Mission (SBM), India's flagship and the world's largest sanitation programme, aims to accelerate universal access to sanitation in rural and urban India.4 Since its launch in 2014, SBM reports building close to 100 million toilets4,5 by way of providing financial incentives to needy families, involving local governments and communities in construction and in monitoring progress, and by conducting mass awareness campaigns.

[Comment] Anal incontinence after caesarean and vaginal delivery

Fri, 22 Mar 2019 00:00:07 +0000

The prevalence of anal incontinence is estimated to be 4·3%, increasing to 6·2% in women over the age of 60 years.1 Anal incontinence profoundly affects the mental and physical health of patients and negatively affects quality of life; it is associated with increased incidence of anxiety, depression, and mortality.2–4 The average annual medical costs per person per year are estimated at US$2353 and non-medical costs at $209, as well as a loss of $1549 per person per year in indirect medical costs due to loss of productivity.

[Comment] Assessing in-vitro fertilisation at age 40 years

Fri, 22 Mar 2019 00:00:07 +0000

In the four decades since the first birth by in-vitro fertilisation (IVF),1 the field has been rewarded with a Nobel prize,2 seen IVF evolve from an experimental procedure into clinical routine, and witnessed a pronounced shift in treatment utilisation from intrauterine inseminations to IVF. However, many studies have shown inferior newborn outcomes with IVF by comparison with spontaneously conceived pregnancies. These observed differences in infant outcomes have been suggested to be a bystander effect, reflective of underlying phenotypes of women who needed IVF to conceive.

[Comment] Video-observed therapy for tuberculosis: strengthening care

Fri, 22 Mar 2019 00:00:07 +0000

Despite being treatable since 1948, tuberculosis continues to cause disease in more than 9 million people each year, and almost 1·5 million largely preventable deaths.1 Tuberculosis has overtaken HIV as the leading infectious killer of adults worldwide and, through airborne spread of untreated drug-resistant strains, is the largest contributor to global deaths due to antimicrobial drug resistance.2 However, this situation can be changed. A solution—outlined in the 2015 Lancet Series How to eliminate tuberculosis1—involves finding and treating those sick with tuberculosis disease, finding and treating those infected with Mycobacterium tuberculosis before they get the disease (ie, tuberculosis preventive therapy), and providing the necessary care so that those with tuberculosis infection and disease can complete treatment.

[Comment] No benefit of chlorhexidine bathing in non-critical care units

Fri, 22 Mar 2019 00:00:07 +0000

Health-care-associated infections remain the most frequent and serious complications related to health care around the world. Millions of patients in the USA, for example, continue to acquire health-care-associated infections each year, resulting in thousands of deaths and additional costs of more than US$10 billion to the American health-care system.1 As patients' skin and noses are major reservoirs for pathogens, universal decolonisation has been advocated as a means of reducing health-care-associated infections and limiting the transmission of multidrug-resistant organisms.

[Editorial] On the question of water: a matter of life and death

Fri, 22 Mar 2019 00:00:07 +0000

The theme of this year's World Water Day on March 22—Leaving No One Behind—is a commitment to those who are disproportionately affected by insufficient access to safe water, such as women, children, refugees, and socioeconomically marginalised people. The urgency of this task is cemented in Sustainable Development Goal (SDG) 6—to ensure the availability and sustainable management of water, the provision of adequate and equitable sanitation and hygiene, and cessation of open defecation by 2030. The staggering number of people for whom safe water trickles in insufficient quantity and quality—2 billion according to the UN—begs the question of how such a target could ever be reached.

[Editorial] A tiered health-care delivery system for China

Fri, 22 Mar 2019 00:00:07 +0000

“China's health-care reform will be regarded as successful when a tiered health-care delivery system is fully achieved”, said the head of China's National Health Commission, Minister Ma Xiaowei, on March 8, during this year's “two Sessions” (the annual meetings of the national legislature and the top political advisory body).

[Editorial] Venezuelans' right to health crumbles amid political crisis

Fri, 22 Mar 2019 00:00:07 +0000

The rising prosperity of Venezuela during the 20th century helped to consolidate gains in health outcomes made over decades. Now, a country rich in natural resources is submerged in a complex humanitarian emergency due to the politico-economic crisis that started in 2008, progressively destroying the health-care system.

Congo Ebola Outbreak Spreads to City of Bunia

Thu, 21 Mar 2019 19:29:35 +0000

Health authorities in Democratic Republic of Congo have confirmed a case of Ebola in another city of close to 1 million people, the health ministry said on Wednesday.
Reuters Health Information

Science Issues Concern About HIV Remission Monkey Study

Thu, 21 Mar 2019 18:04:48 +0000

A once-promising strategy for HIV suppression failed to show efficacy in humans; now Science publishes an "editorial expression of concern" about the monkey study on which it was based.
Medscape Medical News

Some Medical Apps Routinely Share Data

Thu, 21 Mar 2019 16:05:46 +0000

Study authors advise clinicians to be aware of the privacy risks when they use such apps themselves or recommend them to patients.
Medscape Medical News

FDA Approves Optimizer Implant for CRT-Ineligible Heart Failure

Thu, 21 Mar 2019 16:19:18 +0000

The Impulse Dynamics pulse generator and endocardial lead system doesn't engage cardiac rhythm but is said to remodel heart muscle and function with long-term use, making pumping more efficient.
FDA Approvals

Diversity Missing in Genetic Studies

Thu, 21 Mar 2019 16:19:29 +0000

European populations are overrepresented in genetic and genomic studies, contributing to healthcare inequities.
Medscape Medical News

Mississippi Governor Signs 'Heartbeat' Abortion Ban

Thu, 21 Mar 2019 16:17:45 +0000

Mississippi's Republican governor signed one of America's strictest abortion bills on Thursday banning women from obtaining an abortion once a fetal heartbeat is detected, which can often occur before a woman even realizes she is pregnant.
Reuters Health Information

Breast Implant ALCL: Excellent Prognosis if Treated Promptly

Thu, 21 Mar 2019 15:25:02 +0000

Clinicians encouraged to follow 2019 NCCN guidelines, discuss risks, symptoms as part of patient consent for textured breast implants.
Medscape Medical News

FDA Permits Temporary Distribution of Tainted Losartan

Thu, 21 Mar 2019 14:08:25 +0000

To ensure patient access, certain losartan manufacturers can temporarily distribute the medication with higher levels of the probable carcinogen, the agency said.
News Alerts

COACT: Delayed Cath Safe in Some Non-STEMI Cardiac Arrest

Thu, 21 Mar 2019 14:20:15 +0000

No more rush to angiography for resuscitated out-of-hospital arrest? Outcomes were similar with delayed cath, but caution: it was a select group without known indications for invasive intervention.
Medscape Medical News

Hopes Dashed for Aducanumab in Alzheimer's Disease

Thu, 21 Mar 2019 14:26:02 +0000

The phase 3 ENGAGE and EMERGE trials, which were assessing the novel amyloid-B-targeting agent aducanumab for Alzheimer's-related dementia, have been discontinued due to futility.
Medscape Medical News

Seizure Freedom in TLE Tied to Piriform Cortex Resection

Thu, 21 Mar 2019 14:34:13 +0000

Results from a study of individuals with temporal lobe epilepsy (TLE) who underwent surgery could have important implications in terms of a target for drug development and deep brain stimulation.
Medscape Medical News

Советы врачей в духе "вам нужно похудеть" не работают

Thu, 21 Mar 2019 20:40:32 +0000

Когда речь идет о похудении, огромное значение имеет то, как именно врачи дают свои рекомендации.

FDA Clears Solriamfetol (Sunosi) for Narcolepsy, OSA

Thu, 21 Mar 2019 10:40:48 +0000

The dual-acting dopamine and norepinephrine reuptake inhibitor showed durable effects in reducing excessive sleepiness in patients with narcolepsy or obstructive sleep apnea.
FDA Approvals

Deep Dive Into COAPT Echo Results Raises More Questions

Thu, 21 Mar 2019 13:37:59 +0000

The echocardiographic data provide new insights, but experts are seeking more information amid a new expanded indication for the MitraClip.
Medscape Medical News

Liquid Biopsy Spots Early Liver Cancer in Patients With HBV Infection

Thu, 21 Mar 2019 11:51:48 +0000

In high-risk patients with asymptomatic hepatitis B virus (HBV) infection, a liquid biopsy shows promise in detecting early-stage hepatocellular carcinoma (HCC), according to Chinese and U.S. researchers.
Reuters Health Information

Program Improves Communication Between Oncology Clinicians and Patients

Thu, 21 Mar 2019 11:57:47 +0000

The Serious Illness Care Program helps oncologists have better serious-illness conversations with patients without creating anxiety or depression, according to results of a cluster-randomized clinical trial.
Reuters Health Information

POET: No Late Failure With Oral Antibiotic for Endocarditis

Thu, 21 Mar 2019 12:08:33 +0000

Longer-term follow-up of patients with left-sided infectious endocarditis shows no delayed issues with an early switch to oral from IV antibiotics.
Medscape Medical News

Women Fare Worse After Thoracic Aortic Surgery

Thu, 21 Mar 2019 12:42:28 +0000

Older age at surgery for women and surgical repair later in the disease process may contribute to this disparity.
Medscape Medical News

Worry After Prostatectomy a Self-fulfilling Prophecy

Thu, 21 Mar 2019 10:05:11 +0000

Three years after a radical prostatectomy, men with the personality trait of neuroticism scored worse on urinary, bowel, sexual, and hormonal domains.
Medscape Medical News

FDA Clears Solriamfetol (Sunosi) for Narcolepsy, OSA

Thu, 21 Mar 2019 10:40:48 +0000

The dual-acting dopamine and norepinephrine reuptake inhibitor showed durable effects in reducing excessive sleepiness in patients with narcolepsy or obstructive sleep apnea.
Medscape Medical News

Clinical Trials of Venetoclax in Myeloma Stopped Due to Deaths

Thu, 21 Mar 2019 06:46:04 +0000

The FDA issued a partial hold on all ongoing clinical trials evaluating venetoclax in multiple myeloma because of an excessive number of deaths seen in the BELLINI study.
News Alerts

Русскоговорящее сообщество оказалось в центре вспышки кори в штате Вашингтон

Thu, 21 Mar 2019 11:32:59 +0000

Русскоязычное сообщество в округе Кларк, Вашингтон, стало очагом вспышки кори, охватившей 72 человек, большинство из которых составляют дети, пишет издание Vox. Сообщается, что недавние вспышки кори в США зачастую начинают распространяются в сплоченных и традиционных сообществах.

Pediatrician Who Sexually Abused 31 Children Gets 79 Years

Wed, 20 Mar 2019 17:12:43 +0000

Johnnie Barto of Pennsylvania, now 71, was cleared in 2000 by the state medical board on charges he molested two girls after regulators found the charges were 'incongruous' to his reputation.
Medscape Medical News

Some ADHD Meds Tied to a Higher Psychosis Risk Than Others

Wed, 20 Mar 2019 17:37:40 +0000

Amphetamines are associated with a higher psychosis risk than methylphenidate in young patients who take these agents to treat attention deficit hyperactivity disorder.
Medscape Medical News

Kale Is a Surprise on 2019's 'Dirty Dozen' List

Wed, 20 Mar 2019 16:03:56 +0000

Kale took third place on this year's 'Dirty Dozen' list of fruits and vegetables with the most pesticide residue. Strawberries and spinach took first and second, as they did on last year's list.
WebMD Health News

NOMAS: Depression Tied to Increased Stroke Risk

Wed, 20 Mar 2019 16:26:35 +0000

Post-stroke depression has been previously associated with poorer recovery, but new research suggests depression may also be a risk factor for stroke.
Medscape Medical News

In-Hospital Flu Shot Associated With Lower Risk for MI

Wed, 20 Mar 2019 14:59:20 +0000

Only 2% of in-patients received a flu shot in this study, but three large randomized trials are expected to report next year, which may help convince skeptics of the heart-heath benefits of flu shots.
Medscape Medical News

Five Eye Emergencies That Need Quick Referral to Specialist

Wed, 20 Mar 2019 15:37:10 +0000

With some emergencies, patients will not have pain, which can lead to missed diagnoses and loss of crucial time, an ophthalmologist who will speak at the upcoming internal medicine meeting says.
Medscape Medical News

Treating Parents Effective for Child Anxiety

Wed, 20 Mar 2019 15:38:29 +0000

A novel program that helps parents decrease "family accommodation" is as effective for reducing anxiety in their offspring as cognitive behavioral therapy for the child, new research suggests.
Medscape Medical News

Urinary Stones in Children Hard to Sidestep

Wed, 20 Mar 2019 14:13:59 +0000

Urinary tract stones in children can be effectively treated with pint-sized instruments and emerging technologies, research shows, although best-practice evidence is lacking.
Medscape Medical News

Severe Adverse Events When Osimertinib Follows Immunotherapy

Wed, 20 Mar 2019 14:23:30 +0000

Severe immune-related adverse events have been observed when osimrtinib was given after, but not before, immune checkpoint inhibitors in patients with advanced NSCLC.
Medscape Medical News

E-Cig Giant Juul Touts Positive Study in a Questionable Journal

Wed, 20 Mar 2019 14:24:30 +0000

Juul Laboratories, which dominates the US e-cigarette market, is promoting a positive, peer-reviewed study of one of its products that is published in a 'predatory' journal.
Medscape Medical News

WHO Panel Calls for Registry of All Human Gene Editing Research

Wed, 20 Mar 2019 13:10:19 +0000

It would be irresponsible for any scientist to conduct human gene-editing studies in people, and a central registry of research plans should be set up to ensure transparency, World Health Organization experts said on Tuesday.
Reuters Health Information

Real-world Data Support Safety of TAVR in Bicuspid Stenosis

Wed, 20 Mar 2019 13:44:54 +0000

Results were positive but observers were split over whether a randomized controlled trial is still needed to validate the now off-label procedure.
Medscape Medical News

Mushrooms May Cut Cognitive Impairment Risk

Wed, 20 Mar 2019 13:51:13 +0000

Healthy diet and lifestyle are increasingly being linked to a lower risk of mild cognitive impairment or dementia. New research suggests mushrooms may have particular neuroprotective effects.
Medscape Medical News

No Survival Benefit for Volatile Anesthesia in Elective CABG Surgery

Wed, 20 Mar 2019 12:00:20 +0000

In a comparison of gas versus needle, a new pragmatic trial has shown that using a volatile anesthesia agent during elective coronary-artery bypass grafting (CABG) did not produce fewer deaths after one year.
Reuters Health Information

Semaglutide Plus SGLT-2 Inhibitor Reduces HbA1c, Body Weight

Wed, 20 Mar 2019 12:28:55 +0000

Semaglutide is an effective add-on treatment for patients whose type 2 diabetes is not well controlled on sodium-glucose cotransporter-2 (SGLT-2) inhibitors, new research shows.
Reuters Health Information

Fact-Checking Finds Many Errors in Published Nucleotide-Sequence Reagents

Wed, 20 Mar 2019 12:51:32 +0000

A semiautomated fact-checking tool, the Seek & Blastn tool, has found numerous errors in nucleotide-sequence reagents in biomedical research publications, researchers report.
Reuters Health Information

RACE 7 ACWAS: Delayed Cardioversion Effective for Recent-Onset AF

Wed, 20 Mar 2019 12:14:44 +0000

Delaying cardioversion is as safe and effective as acute cardioversion for recent-onset atrial fibrillation, a randomized trial shows. Many cases revert to sinus rhythm without cardioversion.
Medscape Medical News

Чай с температурой выше 65 градусов связали с раком пищевода

Wed, 20 Mar 2019 18:21:17 +0000

Исследователи обнаружили, что у людей, которые пили чай с температурой выше 60 градусов Цельсия в количествах более 700 мл в день, риск развития рака пищевода был на 90% выше по сравнению с теми, кто пил не столь горячий чай или меньше. Эксперты считают, что проблема не в типе напитка, а в его температуре.

High Potency Cannabis Tied to 50% of New Psychosis Cases

Wed, 20 Mar 2019 11:21:12 +0000

High potency cannabis may be linked to half of all new cases of psychosis in Amsterdam and about a third in London, two cities where high potency cannabis is widely available.
Medscape Medical News

Intensive BP Meds in Elderly May Slow Hypertensive Brain Damage

Wed, 20 Mar 2019 11:34:30 +0000

The benefit by MRI in the small randomized INFINITY study with patients 75 years and older didn't come with improved cognition or mobility, but it also didn't raise risk of falling or syncope.
Medscape Medical News

Ранее введение "опасных" продуктов в рацион ребенка снижает риск пищевой аллергии

Wed, 20 Mar 2019 17:10:54 +0000

В новом руководстве по профилактике пищевой аллергии продолжается либерализация введения продуктов, вызывающих сильную аллергию. Например, авторы считают, что есть убедительные доказательства предупреждения развития аллергии на арахис у детей с высоким риском при целенаправленном раннем введении арахиса с 4-х месяцев.

Simple New Urine Test for Preeclampsia Could Save Many Lives

Wed, 20 Mar 2019 10:14:58 +0000

Pilot study finds new bedside urine test may improve diagnosis of preeclampsia. The Congo Red Dot test is under commercial development with a focus on affordability for use around the world.
Medscape Medical News

Overturning Dogma -- Using Testosterone in Prostate Cancer

Wed, 20 Mar 2019 09:39:21 +0000

Testosterone replacement therapy decreased the risk for biochemical recurrence in some men and delayed time to recurrence in others, findings that took investigators by surprise.
Medscape Medical News

Should Medicine Offer Money-Back Guarantees?

Wed, 20 Mar 2019 09:52:04 +0000

Pfizer will offer partial rebates to Chinese patients for the drug palbociclib if their disease progresses.
Medscape Reader Polls

Physicians, Nurses Prioritize Mindfulness Differently

Wed, 20 Mar 2019 07:01:14 +0000

Anxiety and stress were the most common conditions for which providers prescribed mindfulness interventions. Deep breathing and meditation were the top methods of choice.
Medscape Medical News

«Думаю, что уже в этом году мы почувствуем улучшения»

Wed, 20 Mar 2019 11:00:23 +0000

30% онкопациентов в течение года до постановки диагноза обращались за медпомощью, но из-за нехватки знаний у врачей не направлялись к онкологу, а экспертиза качества онкологической помощи выявила различные нарушения в 44% случаев. Отрасль недофинансирована и отстает технологически. Переломить ситуацию должна реализация федерального проекта по борьбе раком, надеются специалисты.

FDA Approves Brexanolone (Zulresso), First Drug for Postpartum Depression

Tue, 19 Mar 2019 19:21:51 +0000

The drug can be given only in a certified facility, and women will have to stay for the entire 2.5 days it takes for the infusion.
FDA Approvals

FDA Approves Brexanolone (Zulresso), First Drug for Postpartum Depression

Tue, 19 Mar 2019 19:21:51 +0000

FDA Approvals

Brief Checklist Facilitates Triage After Anthrax Mass Exposure Event

Tue, 19 Mar 2019 16:06:55 +0000

A brief checklist of signs and symptoms accurately distinguishes anthrax from other conditions and identifies individuals requiring treatment or diagnostic testing after a mass exposure event, researchers report.
Reuters Health Information

Night-shift Workers Bothered by Nocturia, Urgency

Tue, 19 Mar 2019 15:51:28 +0000

Healthcare workers with overnight shifts have more lower urinary tract symptoms and worse quality-of-life scores than day-shift workers, according to a new survey.
Medscape Medical News

Monthly Shots for HIV Within Reach

Tue, 19 Mar 2019 14:04:42 +0000

Two new trials, ATLAS and FLAIR, are being heralded as making landmark advances in HIV care and have shown noninferiority with a totally new paradigm of treatment.
Medscape Medical News

Chiropractic Care Tied to Significant Reduction in Opioid Scripts

Tue, 19 Mar 2019 14:06:20 +0000

Patients who visit a chiropractor for low-back and neck pain are less likely to receive prescription opioids than their counterparts who go to other healthcare providers, new research suggests.
Medscape Medical News

Will Curtailing Opioids Increase Violence Against Doctors?

Tue, 19 Mar 2019 14:09:43 +0000

As doctors endeavor to comply with CDC guidelines aimed at reducing opioid use in patients experiencing non-cancer pain, it's possible they may encounter an increase in patient violence, two pain experts warn.
Medscape Medical News

Portable Thermal Ablation Device for Cervical Precancers

Tue, 19 Mar 2019 13:21:51 +0000

The battery-powered device would be useful in resource-poor countries by allowing women to be screened and then treated immediately by nurses, even when there is no electricity.
Medscape Medical News

Novel Handheld Device Detects High-Risk HPV in 2 Hours

Tue, 19 Mar 2019 11:49:47 +0000

Several innovative strategies are successfully detecting high-risk human papillomavirus (HPV) types with technologies that do not require a resource-rich setting to perform well.
Medscape Medical News

Death by 1000 Clicks: Where EHRs Went Wrong

Tue, 19 Mar 2019 12:20:37 +0000

Electronic Health Records were supposed to make medicine safer, usher in an era of better care, empower patients, and save money. A KHN/Fortune investigation shows that much improvement is needed.
Kaiser Health News

AF Cryoablation Foregoes Vein Mapping With Good Outcomes

Tue, 19 Mar 2019 12:29:52 +0000

Balloon cryoablation for AF without pulmonary vein mapping had outcomes similar to conventional cryoablation and was better than medical management in terms of hospital episodes, new data show.
Medscape Medical News

'Fast' MRI Speeds Prostate Imaging, But Only in Expert Hands

Tue, 19 Mar 2019 11:09:27 +0000

The fast technique was comparable with slower, more complex MRI techniques in cases of suspected prostate cancers, but expert image readers are essential to the process at present.
Medscape Medical News

Psychosocial Factors Impact Cancer Surgery Outcomes

Tue, 19 Mar 2019 09:58:17 +0000

Postop complication rates rose threefold and unplanned readmission rates sixfold in comorbid patients with two or more psychosocial risk factors.
Medscape Medical News

Cancer Drugs Dominate Top 10 Best-Selling Drugs in 2018

Tue, 19 Mar 2019 10:00:49 +0000

But Humira is the top seller in US 2 years running, while two immune checkpoint inhibitors break into the top 10.
Medscape Medical News

Aspirin May Lower HCC Risk in Patients With Hepatitis B

Tue, 19 Mar 2019 10:02:18 +0000

A new study finds that daily low-dose aspirin may decrease the risk for hepatocellular carcinoma in patients with chronic hepatitis B infection.
Medscape Medical News

EPA's Methylene Chloride Ban Excludes Workers

Tue, 19 Mar 2019 10:43:59 +0000

The chemical is found in paint strippers. Stores like Lowe's and Walmart have stopped selling products containing it, but environmental advocates say workers should be protected too.
WebMD Health News

Moderate Muscle Strength Key to Type 2 Diabetes Prevention

Tue, 19 Mar 2019 10:53:07 +0000

Moderate levels of resistance training should be encouraged to reduce the risk of developing type 2 diabetes, US findings suggest, although conversely, high-strength training may negate the effect.
Medscape Medical News

Light Activity Lowers Cardiovascular Risk in Older Women

Tue, 19 Mar 2019 09:40:57 +0000

The prospective trial, which used objectively measured movement, found that the performance of regular household tasks was associated with significant reductions in cardiovascular risk.
Medscape Medical News

Behavioral Therapy as Good as Meds for Incontinence

Tue, 19 Mar 2019 08:35:08 +0000

A network meta-analysis suggests behavioral therapy may be as good as medication for treating urinary incontinence in women; the results confirm international guidelines.
Medscape Medical News

Аллергия в пробирке

Tue, 19 Mar 2019 12:59:29 +0000

По данным ВОЗ, 40 % населения планеты страдают сегодня аллергией. Осложняет ситуацию и то, что эту болезнь часто принимают за ОРВИ или, наоборот, предполагая возможность аллергии там, где ее нет, начинают прием антигистаминных препаратов. Предварительно поставить диагноз может только врач, а для его подтверждения требуются специальные исследования, напоминают специалисты.

Most New HIV Cases Stem From People Undiagnosed or Untreated

Tue, 19 Mar 2019 06:45:26 +0000

Ensuring that more people are tested and are receiving HIV care is the foundation of the recently announced federal initiative to cut new infections by at least 90% during the next 10 years.
Medscape Medical News

Ученые объяснили, почему молодые люди склонны к рискованному сексуальному поведению

Tue, 19 Mar 2019 12:50:14 +0000

Пол, сексуальная ориентация и желание длительных отношений – факторы, которые влияют на проявления рискованного сексуального поведения среди молодых людей. Гетеросексуальные мужчины реже хотят использовать презерватив, гомосексуальные мужчины больше склонны к обсуждению. Женщины пренебрегают рисками, когда рассчитывают на длительные отношения.

Сахаросодержащие напитки сокращают продолжительность жизни

Tue, 19 Mar 2019 10:22:12 +0000

Согласно крупному многолетнему исследованию, чем больше сахаросодержащих напитков выпивает человек, тем выше у него риск преждевременной смерти. В первую очередь увеличивается вероятность смерти от сердечно-сосудистых заболеваний и в меньшей степени от рака. Риск преждевременной смерти, связанный с употреблением этих напитков, был более выраженным среди женщин.

PCKS9 Alirocumab Picks Up New European Indication

Mon, 18 Mar 2019 17:04:44 +0000

On the basis of ODYSSEY OUTCOMES results, alirocumab is now approved in Europe to reduce cardiovascular risk in adults with established disease.
International Approvals

Pulmonary Fibrosis Foundation Warns Against Stem Cell Infusions

Mon, 18 Mar 2019 17:14:33 +0000

The foundation calls for-profit stem cell centers 'the modern-day equivalent of snake oil' and warned against having stem cell treatments except in clinical trials.
Medscape Medical News

Immunotherapy Should Be First Line in Merkel Cell Carcinoma

Mon, 18 Mar 2019 15:38:03 +0000

Pembrolizumab demonstrated durable tumor control, a generally manageable safety profile, and favorable survival outcomes compared with historical data in advanced MCC.
Medscape Medical News

Ripple Effect: Repackaged Losartan Recalled Due to Impurity

Mon, 18 Mar 2019 15:40:39 +0000

Legacy Pharmaceutical recalls 43 repackaged lots of losartan because of the presence of the probable carcinogen N-nitroso-N-methyl-4-aminobutyric acid (NMBA) in the active pharmaceutical ingredient.
News Alerts

Chemo for Early-Stage Prostate Cancer? RTOG 0521 Says Maybe

Mon, 18 Mar 2019 13:56:50 +0000

In major clinical trial, docetaxel, which is typically used in metastatic disease, improved outcomes in high-risk, early-stage disease. However, the survival results fell short of the trial target.
Medscape Medical News

From Bench to Bedside: ENDO 2019 Ties Science to Clinical Care

Mon, 18 Mar 2019 14:18:16 +0000

'What distinguishes ENDO from other meetings is that you get a curated view of what is the newest, hottest, and best in science, which you know...is going to be impacting care.'
Medscape Medical News

New Study Ties Egg and Cholesterol Consumption to Heart Disease Risk

Mon, 18 Mar 2019 13:38:18 +0000

After a raft of studies reassuring consumers that eggs are OK to eat, a new report associates an increasing risk of heart disease with the increasing consumption of eggs.
Reuters Health Information

Phone Intervention for Patients Most At Risk Improves HbA1c

Mon, 18 Mar 2019 13:04:16 +0000

Pharmacist-led phone interventions to improve insulin adherence in patients with diabetes worked best when those at highest risk of noncompliance were targeted.
Medscape Medical News

В разных странах люди чувствуют себя на 65 лет в разном возрасте

Mon, 18 Mar 2019 11:15:39 +0000

В каком возрасте люди «чувствуют себя на 65 лет», зависит от страны их проживания, показало исследование, опубликованноев журнале Lancet Public Health. Разница может составлять 30 лет. В России люди чувствуют себя на 65 лет в среднем в возрасте 59,2, на Украине – 57,4, а в Беларуси – 60,5.

Только малая часть рекомендаций по болезням сердца подкреплена качественными исследованиями

Mon, 18 Mar 2019 18:48:10 +0000

Менее 10% рекомендаций лечения сердечно-сосудистых заболеваний опираются на так называемый «золотой стандарт» – данные, полученные в результате крупных рандомизированных контролируемых клинических исследований и мета-анализа. Но ученые подчеркивают, что текущие руководства остаются важнейшим документом, на котором должно быть основано лечение.

WRAP-IT: Antibacterial Pouch Cuts Device Infections

Mon, 18 Mar 2019 12:19:25 +0000

The trial provides the first randomized data supporting prophylaxis with the long-available TYRX envelope, but cost continues to be a consideration.
Medscape Medical News

Stroke Mortality Down, but Global Burden Remains High

Mon, 18 Mar 2019 12:50:17 +0000

Although the global stroke mortality rate dropped substantially from 1990 to 2016, the global burden of stroke is still high, with more than 80 million stroke survivors, new data show.
Medscape Medical News

Novel Program Trains Nurse Practitioners to Manage Pain Patients

Mon, 18 Mar 2019 11:35:47 +0000

In a unique educational program, nurse practitioners learned how to examine patients with shoulder and knee pain and how to determine which patients require specialist referral.
Medscape Medical News

Lifestyle Changes Do a Number on PSA Values

Mon, 18 Mar 2019 11:41:23 +0000

Two month's abstinence from a few of life's pleasures obviated the need for prostate biopsy in nearly half of men who adopted the lifestyle changes.
Medscape Medical News

Could Ultrasound Serve as an Early Bone Density Screening Tool?

Mon, 18 Mar 2019 10:11:27 +0000

A small study suggests ultrasound of the heel bone could be a preliminary way of assessing bone density. The idea has been around for more than 30 years but has never taken off, says an expert.
Medscape Medical News

Hopeful Heart: Team Care for Mood Plus HF Improves Wellbeing

Mon, 18 Mar 2019 10:11:54 +0000

There is hope for improving mood and quality of life for heart failure patients with depression, a new trial suggests. Two-pronged care by a nurse care manager plus a diverse team topped usual care.
Medscape Medical News

Autism, Depression Tied to Prenatal Maternal Infection

Mon, 18 Mar 2019 08:57:07 +0000

A study of more than 1.5 million children suggests those who had been exposed to maternal infection in utero are at significantly greater risk of developing autism or depression during their lifetime.
Medscape Medical News

Ученые подтвердили опасность яиц и пищевого холестерина для здоровья сердца

Mon, 18 Mar 2019 13:05:33 +0000

300 мг пищевого холестерина в день повышают риск сердечно-сосудистых заболеваний на 17% и увеличивают риск смерти от всех причин на 18%. Яичные желтки являются одним из самых богатых источников пищевого холестерина среди всех продуктов, один желток содержит до 186 мг.

В разных странах люди чувствуют себя на 65 лет в разном возрасте

Mon, 18 Mar 2019 11:15:39 +0000

В каком возрасте люди «чувствуют себя на 65 лет» зависит от страны их проживания, показало исследование, опубликованноев журнале Lancet Public Health. Разница может составлять 30 лет. В России люди чувствуют себя на 65 лет в среднем в возрасте 59,2, на Украине – 57,4, а в Беларуси – 60,5.

TAVR Low-Risk Studies Get Standing Ovation at ACC

Sun, 17 Mar 2019 20:23:22 +0000

The success of the two trials of transcatheter aortic valve replacement in low-surgical-risk patients stole the show at the ACC today.
Medscape Medical News

New AHA/ACC CVD Primary Prevention Guideline

Sun, 17 Mar 2019 18:57:41 +0000

As expected, the new document recommends generally against aspirin in primary prevention, and aims to make a 'one-stop shop' for clinicians.
Medscape Medical News

AUGUSTUS Backs Apixaban 'Double Therapy' in Most AF Post-ACS, PCI

Sun, 17 Mar 2019 11:48:46 +0000

The most safe and effective antithrombotic regimen may involve neither warfarin nor aspirin, suggested a trial that might allay bleeding-risk concerns in a tough-to-treat atrial fibrillation population.
Medscape Medical News

Apple Watch Helps Detect AF: Is This the Future?

Sat, 16 Mar 2019 19:52:21 +0000

The first study of its kind involving more than 400,000 members of the general population used an Apple Watch to identify irregular pulse and received a mixed response from ACC delegates.
Medscape Medical News

HoT-PE Puts Early Discharge for Low-Risk PE on Front Burner

Sat, 16 Mar 2019 18:47:06 +0000

The findings strengthen consideration of home treatment for patients at sufficiently low risk and raise the issue of whether hospital admission is a necessary step at all.
Medscape Medical News

CABANA Published: Mixed Results, Helpful Insights

Sat, 16 Mar 2019 16:53:25 +0000

Primary clinical outcomes were similar for catheter ablation and meds-only in the atrial fibrillation trial. But secondary ablation advantages could help inform shared decision-making, say observers.
Medscape Medical News

Testicular Sperm Better for Intracytoplasmic Injection

Sat, 16 Mar 2019 16:12:48 +0000

For men with persistent DNA fragmentation, testicular aspiration could produce sperm with more DNA integrity than ejaculated sperm, improving assisted fertilization outcomes, new research shows.
Medscape Medical News

TAVR With Evolut: Interim Results Promising in Low-Risk Patients

Sat, 16 Mar 2019 16:17:00 +0000

The transcatheter procedure was noninferior to surgery in an interim Bayesian analysis of the primary endpoint -- death from any cause or disabling stroke at 24 months -- in a new trial involving patients with severe aortic stenosis at low surgical risk.
Medscape Medical News

PARTNER 3: TAVR Success in Low-Risk Patients

Sat, 16 Mar 2019 15:39:10 +0000

The procedure using the SAPIEN 3 valve showed a significantly lower rate of death, stroke, and rehospitalization at 1 year vs surgery in patients with severe aortic stenosis at low surgical risk.
Medscape Medical News

FDA Warns of Mortality Signal With Paclitaxel Devices in PAD

Fri, 15 Mar 2019 18:54:10 +0000

Preliminary analysis of long-term data finds a 50% increase in risk for mortality in patients treated with paclitaxel-coated devices for peripheral arterial disease.
News Alerts

Virginia Med School Gets Diversity Honor Amid Blackface Outrage

Fri, 15 Mar 2019 19:39:31 +0000

The nomination was submitted before the controversy but the award was accepted weeks afterward.
Medscape Medical News

Excess Pregnancy Weight Gain Tied to Risk for Delivery Complications

Fri, 15 Mar 2019 18:03:58 +0000

Women who gain more weight than recommended while pregnant may increase their chances for serious complications at delivery, a study of more than a half-million births in New York City suggests.
Reuters Health Information

Cuba Says USA, Not Canada, Manipulating Diplomat Health Incidents

Fri, 15 Mar 2019 17:51:39 +0000

Cuba denounced the Trump administration on Thursday for continuing to refer to health incidents among their diplomats in Havana as "attacks" without presenting any evidence, saying it was part of a broader campaign to damage bilateral relations.
Reuters Health Information

Residency Match Day Is Largest in History

Fri, 15 Mar 2019 17:04:37 +0000

A record 38,376 US and international applicants submitted program choices for 35,185 positions; 80% of applicants matched to PGY-1 positions, and 95% of PGY-1 positions were filled.
Medscape Medical News

Optical Technologies Unreliable at Diagnosing Pre-Cancerous Colorectal Polyps

Fri, 15 Mar 2019 16:13:17 +0000

The accuracy of optical technologies in differentiating cancerous from benign tissue is "insufficient" for most routine clinical applications, including diagnosing pre-cancerous colorectal polyps, researchers say.
Reuters Health Information

App to Detect Diabetes by Smartphone Fingertip Scan

Fri, 15 Mar 2019 16:04:13 +0000

A smartphone-based diabetes screening test using contact photolethysmography was reasonably accurate in an early study, but observers agree that an app should not replace regular healthcare visits.
Medscape Medical News

Abnormal Blood Sugar, Cholesterol Common in Middle School

Fri, 15 Mar 2019 16:09:59 +0000

More than one third of middle school students who underwent cardiovascular screening at school had abnormal blood sugar levels or high cholesterol, a pilot study of 45 students found.
Medscape Medical News

Physicians Getting Inventive on Frontline of Opioid Crisis

Fri, 15 Mar 2019 16:30:37 +0000

A multifaceted approach to curb the distribution and consumption of opioids and promote the safe disposal of unused drugs is required to address the largest drug crisis in the nation's history.
Medscape Medical News

Perinatal Death Tripled in Home Compared With Hospital Births

Fri, 15 Mar 2019 14:54:10 +0000

New Israeli study confirms prior evidence that giving birth outside of hospital increases the risks of a range of poor outcomes for baby, including perinatal mortality.
Medscape Medical News

FDA OKs ClearMate Device for Carbon Monoxide Poisoning

Fri, 15 Mar 2019 13:04:56 +0000

The ClearMate device speeds up elimination of CO from the body by delivering 100% oxygen plus a mixture of oxygen and carbon dioxide, causing the patient to breathe faster.
FDA Approvals

Emotional Support Key to Unlocking Eating Disorders in T2D

Fri, 15 Mar 2019 13:32:25 +0000

Eating disorders, which are common in type 1 and type 2 diabetes and can have devastating consequences, need an emphasis on emotional support if outcomes are to be improved, say UK experts.
Medscape News UK

Earpods for Cell Phones — Are There Health Risks?

Fri, 15 Mar 2019 10:50:59 +0000

A recent flurry of media reports have suggested that there may be health risks with using wireless ear pods with cell phones, but is there cause to worry?
Medscape Medical News

AAP Now Endorses Influenza Vaccine Shot and Nasal Spray

Fri, 15 Mar 2019 09:16:59 +0000

The American Academy of Pediatrics has updated its influenza vaccination recommendations, saying both the shot and nasal spray vaccines are acceptable for the 2019-2020 season.
Medscape Medical News

Socially Complex Patients: More Resources Help Docs, Too

Fri, 15 Mar 2019 07:35:52 +0000

Two recent studies suggest that addressing social determinants of health not only helps patients but also improves physician job satisfaction.
Medscape Medical News

«Лучше лечить новыми препаратами, чем тратиться на перелечивание»

Fri, 15 Mar 2019 13:00:17 +0000

Появившиеся несколько лет назад лекарства от гепатита С перевели это заболевание из разряда фатальных в полностью излечимые. В России зарегистрированы препараты, быстро справляющиеся с этой инфекцией, однако регионы, в которых пациентам доступно современное лечение, можно пересчитать по пальцам. Но там, где инновационная терапия применяется, она буквально творит чудеса.

Рак молочной железы включает 11 болезней с разной вероятностью рецидива

Fri, 15 Mar 2019 12:33:43 +0000

Рак молочной железы является 11 генетически различными заболеваниями, каждое из которых имеет свой прогноз и вероятность рецидива (возврата) после лечения. Можно надеяться, что такое детальное распределение пациентов с раком молочной железы обеспечит новые персонализированные подходы к лечению.

Почему мы «спим на ходу»

Fri, 15 Mar 2019 10:33:39 +0000

15 марта отмечается Всемирный день сна. По оценкам Минздрава, от различных нарушений сна страдает каждый пятый житель страны. В результате бессонницы снижается качество жизни и производительность труда, развивается хроническая усталость, серьезные болезни. А с другой стороны за дневную сонливость нередко принимаются проявления усталости, астении или неврологических заболеваний.

[Series] Communication with children and adolescents about the diagnosis of a life-threatening condition in their parent

Fri, 15 Mar 2019 00:00:09 +0000

Many adults diagnosed with a life-threatening condition have children living at home; they and their partners face the dual challenge of coping with the diagnosis while trying to maintain a parenting role. Parents are often uncertain about how, when, and what to tell their children about the condition, and are fearful of the effect on their family. There is evidence that children are often aware that something is seriously wrong and want honest information. Health-care professionals have a key role in supporting and guiding parents and caregivers to communicate with their children about the diagnosis.

[Series] Communication with children and adolescents about the diagnosis of their own life-threatening condition

Fri, 15 Mar 2019 00:00:09 +0000

When a child is diagnosed with a life-threatening condition, one of the most challenging tasks facing health-care professionals is how to communicate this to the child, and to their parents or caregivers. Evidence-based guidelines are urgently needed for all health-care settings, from tertiary referral centres in high-income countries to resource limited environments in low-income and middle-income countries, where rates of child mortality are high. We place this Review in the context of children's developing understanding of illness and death.

[Clinical Picture] A sinister black finding in the stomach

Fri, 15 Mar 2019 00:00:09 +0000

A 68-year-old woman undergoing a routine surveillance endoscopy—part of her follow-up for a Barrett's oesophagus—was found to have a solitary, black lesion, approximately 4 mm in diameter, in the gastric body (figure). Biopsy samples were taken and microscopic examination showed gastric body mucosa with heavily pigmented cells in the lamina propria that infiltrated the crypts without destroying them (figure). Immunohistochemical examination of the biopsied tissue section showed positive staining for melanoma associated antigens using antibodies.

[Articles] Automated insulin dosing guidance to optimise insulin management in patients with type 2 diabetes: a multicentre, randomised controlled trial